Digital Commons Network^™

Exercise Counteracts The Deleterious Effects Of Cancer Cachexia, Stavroula Tsitkanou, Kevin A. Murach, Tyrone Washington, Nicholas P. Greene

Health, Human Performance and Recreation Faculty Publications and Presentations

Cancer cachexia (CC) is a multifactorial syndrome characterised by unintentional loss of body weight and muscle mass in patients with cancer. The major hallmarks associated with CC development and progression include imbalanced protein turnover, inflammatory signalling, mitochondrial dysfunction and satellite cell dysregulation. So far, there is no effective treatment to counteract muscle wasting in patients with CC. Exercise training has been proposed as a potential therapeutic approach for CC. This review provides an overview of the effects of exercise training in CC-related mechanisms as well as how factors such as cancer comorbidities, exercise modality and biological sex can influence exercise …

The Environmental And Nutritional Dilemma Of Beef Production And Consumption, Hannah A. Swilling, Stefano De Rosmini, Brooke Lovan

Chemical Engineering Undergraduate Honors Theses

Based on previous studies, it has been stated that beef production and consumption in the United States is detrimental to the environment. However, in depth studies analyzing the change of beef production and consumption, the environmental impacts, the external costs, the lifestyle implications as well as the nutritional, the social and the cultural aspects of beef have not been conducted. The goal of this study is to analyze the multiple aspects of the dilemma over beef production and consumption. This was done through an analysis of beef production and consumption data over the past 60 years to determine how it …

The Fecal Fermentation Profile Of Infants With Different Feeding Modalities, Willow Lewis, Michelle E. Johnson, William A. Clark, Amy Wahlquist

Undergraduate Honors Theses

Introduction/Background

Research indicates nutrition and environment in the first year of a child's life are crucial in their development and growth and can contribute to lower chances of developing obesity and other health concerns. Key factors that can determine these outcomes include the bacteria and resulting short chain fatty acids (SCFAs) present in the gut. This composition may be affected by feeding modality (formula feeding vs breastfeeding), exposure to the mother’s microbiota, weight status of the child, and type of delivery. This research aims to identify the impact of infant feeding modality on toddlers' fecal fermentation profile, and if there …

The Impact Of Covid-19 On The Opioid Epidemic, Hailey Stewart

Undergraduate Honors Theses

The COVID-19 pandemic adversely affected the lives of most Americans. People with Substance Use Disorder (SUD) were particularly vulnerable to the negative effects brought on by the pandemic. This study explored the increase in deaths due to opioid overdose during the pandemic exacerbated by factors such as increased stress, decrease in treatment options due to social distancing requirements and facility closures, social isolation, and an increase in spare time. Access to treatment for opioid use disorder (OUD) was interrupted by the measures meant to mitigate the spread of COVID-19. Through a systematic review of current literature, it was demonstrated that …

Investigation On Bacterial Signaling Through Generation Of A Ppgpp Biosensor, Andrew Robinson

Undergraduate Honors Theses

Guanosine tetraphosphate (ppGpp) is a bacterial signaling molecule involved in activating the stringent response, a cellular reaction to environmental stress that downregulates cell division and metabolism processes to conserve nutrients. The stringent response is implicated in some instances of antibiotic persistence, so broadening the current understanding of ppGpp signaling is useful. This thesis seeks to generate a ppGpp biosensor that will bind ppGpp and emit fluorescent light in its presence, which will allow for improved research into the pathways and functions of the signaling molecule. To generate a novel ppGpp biosensor, I converted a biosensor previously used to detect cyclic …

An Assessment Evaluating The Possible Participation Of A Virtual Nutrition Education Program For Older Adults, Ashlyn Cobble

Undergraduate Honors Theses

The importance of proper nutrition education among older adults is crucial in promoting overall physical health and management of chronic health conditions. However, access to such education has been limited, especially during the COVID-19 pandemic. With the current boom in social media popularity, as well as virtual communication portals such as Zoom, the question must be asked if nutrition education could be effectively implemented for the use of older adults through these electronic channels. The study design for this particular research was a cross sectional survey to inform development of an online nutrition education program for older adults in Northeast …

Severe Hypoxia Up-Regulates Gluconeogenesis In Daphnia, Morad C. Malek

Undergraduate Honors Theses

Hypoxia is a significant low oxygen state that has complex and diverse impacts on organisms. In aerobes, various adaptive responses to hypoxia are observed that vary depending on the level of oxygen depletion and previous adaptation, hence the continued attention to hypoxia as an important abiotic stressor. Adaptive responses to hypoxia are primarily governed by the hypoxia-inducible factors (HIFs), which activate downstream genetic pathways responsible for oxygen transport and metabolic plasticity. In aquatic habitats, oxygen availability can vary greatly over time and space. Therefore, aquatic organisms’ adaptation to hypoxia is likely pervasive, especially in genotypes originating from waterbodies prone to …

Gastrointestinal Alterations In Two Mouse Models Associated With Social Behavior Deficits, Gracie Leamon

Undergraduate Honors Theses

The gastrointestinal (GI) tract is a diverse habitat for multiple microorganisms. Disturbances in the microbiome of the GI tract have been associated with psychiatric disorders including autism spectrum disorder (ASD). Individuals with ASD, when compared to neurotypical individuals, have demonstrated differing gut species. Also, it has been shown that microbial transplant therapies impact ASD symptoms in patients. Animal models of behaviors associated with ASD might offer insight for the actual role these microbial differences may occupy regarding symptoms. Unfortunately, ASD does not have an accepted animal model where the GI alterations have been thoroughly explored. In this study, we sought …

Home Cooking Quality Assessment Tool Validation Using Community Science And Crowdsourcing Approaches, Margaret Raber, Nalini Ranjit, Larkin L Strong, Karen Basen-Engquist

Faculty, Staff and Student Publications

Objective: To refine a measure of home cooking quality (defined as the usage level of practices with the potential to influence the nutrient content of prepared foods) and conduct a construct validation of the revised tool, the Healthy Cooking Questionnaire 2 (HCQ2).

Design: Two validation approaches are described: (1) a community science approach used to refine and validate Healthy Cooking Questionnaire (HCQ) constructs, and (2) responses to the revised HCQ (HCQ2) in a sample of Amazon Mechanical Turk (MTurk) workers to determine questionnaire comprehension.

Setting: The Community Scientist Program at the University of Texas MD Anderson Cancer Center facilitated discussion …

The Covid-19 Pandemic And Material Hardships: A Qualitative Study Of Undocumented Immigrants In The United States, Erika Chavez-Marroquin

Electronic Theses, Projects, and Dissertations

The study aimed to recognize the financial impact the COVID-19 pandemic had on the undocumented immigrants living in southern California. Utilizing an exploratory method with a qualitative approach. The research interviewed English and Spanish-speaking participants who are a part of the undocumented population and have employee history. The study utilized a purposive and snowball sampling method and explored the financial impact the COVID-19 pandemic had on participants’ personal finances, resources they were able to access, and gaps in programs or additional resources through federal and state aid. Through the data analysis, the research identified the following themes: limitations on accessible …

Accessibility Of Mental Health Resources In Schools, Zitlaly Lizeth Cruz-Roman, Vianney Consepcion Sandoval

Electronic Theses, Projects, and Dissertations

This study aimed to examine parents’ and staff’s perception of the accessibility and awareness of mental health resources in school. Mental health resources are made available in school settings; however, not all families and students are aware of the resources being provided. To address the accessibility of mental health resources, research needs to take place to understand why these resources are not being utilized. Individuals’ mental health will improve by creating awareness of the resources since they will be aware of the resources and use them based on their needs. The research project utilized quantitative research methods and descriptive research …

From Zero To Thrive: A Model Of Cross-System And Cross-Sector Relational Health To Promote Early Childhood Development Across The Child-Serving Ecosystem, Alison L. Miller, Sara F. Stein, Rebeccah Sokol, Rachel Varisco, Phoebe Trout, Megan M. Julian, Julie Ribaudo, Joshua B. Kay, Natasha V. Pilkauskas, Nicole Gardner-Neblett, Todd I. Herrenkohl, Kara Zivin, Maria Muzik, Katherine L. Rosenblum

Articles

Early relational health between caregivers and children is foundational for child health and well-being. Children and caregivers are also embedded within multiple systems and sectors, or a “child-serving ecosystem”, that shapes child development. Although the COVID-19 pandemic has made this embeddedness abundantly clear, systems remain siloed and lack coordination. Fostering relational health amongst layers of this ecosystem may be a way to systematically support young children and families who are facing adversity. We integrate theory, examples, and empirical findings to develop a conceptual model informed by infant mental health and public health frameworks that illustrates how relational health across the …

Combating Childhood Obesity In Rural Areas - A Systematic Review, Ramanjot Bains

Research Papers

No abstract provided.

Enantiomer-Selective Characterization Of The Adsorption, Dissipation, And Phytotoxicity Of The Plant Monoterpene Pulegone In Soils, Jose Antonio Galán-Pérez, Beatriz Gámiz, Ivana Pavlovic, Rafael Celis

Research Outputs: 2025-Present

Plant monoterpenes have received attention for their ecological functions and as potential surrogates for synthetic herbicides, but very little is known about the processes that govern their behavior in the soil environment, and even less about the possible enantioselectivity in the functions and environmental behavior of chiral monoterpenes. We characterized the adsorption and dissipation of the two enantiomers of the chiral monoterpene pulegone in different soils, and their phytotoxicity to different plant species through Petri dish and soil bioassays. R-and S-pulegone displayed a low-to-moderate non-enantioselective adsorption on the soils that involved weak interaction mechanisms. Soil incubation experiments indicated that, once …

Burden Of Food Insecurity Among College Students: A Cross-Sectional Study During The Covid-19 Pandemic, Saba Sami

Electronic Theses, Projects, and Dissertations

Background: Food insecurity is lack of access to proper nutrition for an individual to obtain a healthy lifestyle. The goal of this research is to determine the frequency of food insecurity among college students at a four-year college institution during COVID-19 pandemic in association to mental and physical health status.

Methods: This study was conducted among college students using cross-sectional study method. All data were collection virtually and kept anonymous. All statistical analyses were conducted using SPSS version 28 with (p<.05), denoting significance.

Results: In the study there were a total of 98 participants who were being analyzed. All the participants were …

Can Social Workers Provide Access To Healthier Food Choices To Low-Income Families With Urban Farming, Nayely Chairez

Electronic Theses, Projects, and Dissertations

Background: Low-income communities have higher rates of being food insecure at some point in their lives which can lead to chronic illnesses and have an impact on mental health. Objectives: This research aimed to explore the following: (1) the impact of urban farming in low-income communities and (2) the roles social workers have in addressing food insecurity through urban farming. Methods: This study utilized a qualitative method of collecting data. Data was collected through one-on-one interviews with board members, volunteers, and community members from an urban farm organization. Interviews were conducted and recorded through the online platform …

Coping With The Impact Of The Covid-19 Pandemic In Southern California: A Qualitative Study Of Families In Poverty, Jaqueline Nunez Cruz

Electronic Theses, Projects, and Dissertations

There is a gap in the social welfare literature concerning the perspectives of low-income families about the impact of the COVID-19 pandemic on their lives. This qualitative study contributes to the literature by exploring how families in poverty across Southern California survived the pandemic. Interviews were conducted with 10 heads of household (N = 10) to determine the impact of the pandemic and the strategies used to cope with the crisis. Thematic analysis of the data revealed five key themes: a) the devastating impact of the pandemic on low-income families, b) the use of various coping mechanisms by families, b) …

Bayesian Joint Modeling For Longitudinal Outcomes Of Exponential Families And Informative Time Points, Michael Safo Oduro

Dissertations

The benefits of longitudinal data in clinical research are immense, owing to the potential to detect phenomenon changes and trends over time. An avalanche of traditional methods exist for the analysis of this data kind, most of which are predicated on the assumption of fixed time design for study individuals. This assumption however, is not always tenable. Consider occurrences that can alter the time or visit profile of subjects in a clinical trial, such as adverse events. These may result in not just irregular visit times, but also unbalanced data on subject outcomes. Hence, one can consider visit times to …

Mothers’ Perspectives On Language And Literacy Development In Children With Disabilities Adopted From China, Jessica B. Hovland

Dissertations

Children with disabilities and special needs make up the vast majority of those currently being adopted internationally into the United States (U.S.). China has been a leading sending country for international adoption since the 1990s and remains one of the few nations with thousands of orphaned or abandoned children, many with congenital disabilities or significant medical needs, in government welfare institutions. While most children adopted internationally (CAI), whether from China or other nations, experience developmental catch-up after adoption, children with disabilities and those who spent time in institutional settings exhibit persistent language deficits that impact literacy and academic skills as …

Are Natural Killer Cells Novel Mediators Of The Effects Of Cannabidiol On Mental Health, Sleep Quantity, Sleep Quality, And Immune Function?, Jacob Norbert Kisiolek

Dissertations

Cannabidiol (CBD) has increased in popularity since the United States Farm Bill legalized hemp production in 2018 and is now projected to become a $24.4 billion dollar industry by 2025. Since its legalization, CBD is thought to be an antiepileptic, anxiolytic, and antipsychotic, as well as an agent to improve mental health, quality of life, aspects of sleep and immune function. However, many of these claims lack scientific evidence. The purpose of this randomized, double blind, placebo-controlled trial was to determine the effects of an 8-week CBD intervention on measures of mental health, sleep quantity, sleep quality, and natural killer …

Evaluation Of Mealsense©: A Sensory Integration-Based Feeding Support Program For Parents., Audrey Trewin, Zoe Mailloux, Roseann C Schaaf

Department of Occupational Therapy Faculty Papers

IMPORTANCE: Children with autism spectrum disorder (ASD) often experience feeding challenges related to difficulties with sensory integration.

OBJECTIVE: To evaluate the content, acceptability, and usefulness of MealSense©, an online parent education program for children with ASD who have feeding challenges related to poor sensory integration.

DESIGN: A descriptive study in which experts reviewed and rated MealSense content for consistency with Ayres Sensory Integration® (ASI) principles and evidence-based practices in feeding.

PARTICIPANTS: A convenience sample of expert reviewers (n = 5) and parents of children with ASD and feeding challenges (n = 5).

RESULTS: Expert ratings (n = 5) met criteria …

Weight Gain Trajectory Over Five Years For Adult Primary Care Patients In Nebraska, Elizabeth M. Morris

Capstone Experience: Master of Public Health

INTRODUCTION: The continued rise in the prevalence of adult obesity in the United States is a public health concern. Several studies have identified the increasing rates of obesity, its impacts, and the factors leading to obesity. Some researchers have made obesity prevalence projections at the national and state levels. This study aims to fill the critical gap in real-time weight data trends among primary care adult patients in Nebraska. The main goal of this study is to determine and analyze the weight trajectory of adults in Nebraska over the past five years and determine if the trends vary among age …

Utilizing Re-Aim To Assess Adolescent Weight Loss Interventions: A Systematic Review, Jordan Mccullough

Capstone Experience: Master of Public Health

Adolescent overweight/obesity is an ongoing concern for public health professionals. One out of every five adolescents are overweight, and one out of every three is at risk. Adolescent overweight/obesity is associated with a higher chance of overweight/obesity, premature death, and disability in adulthood. A 2018 systematic review by Moores et al. compared the effectiveness of community-based treatment programs for adolescents (13-17 years) who are overweight and obese by comparing pre-program to post-program changes in weight-related measurements and health-behavior changes. While looking at the effectiveness of a program provides valuable information, other elements (i.e., representativeness of participants, implementation measures such as …

The Effect Of Post-Traumatic Stress Disorder On First Responders Following A Disaster: A Literature Review, Briar Butner

Capstone Experience: Master of Public Health

First responders work in a high-stress environment that can potentially produce traumatic situations. This includes aiding in the recovery and response efforts of critical events such as a disaster. A significant risk factor for developing post-traumatic stress disorder symptoms is people who have been through a disaster (National Institute of Mental Health, 2019). This literature review aims to search for evidence on PTSD in first responders following a disaster, identify the factors associated with the development of PTSD, and make recommendations on best practices to reduce or mitigate the incidences of PTSD. The search was conducted in three academic databases: …

Targeting Inflammation In Heat-Stressed Wethers Improves Growth And Efficiency And Alters Body Composition: A Brief Exploration And Application Of Extension Principles, Micah Samuel Most

Department of Animal Science: Dissertations, Theses, and Student Research

The objective of our first study was to determine how administering anti-inflammatory dexamethasone and ω-3 polyunsaturated fatty acid (PUFA)-rich fish oil affects growth efficiency and body composition in heat-stressed finishing lambs. Commercial wethers were randomly assigned to be fed under heat stress (35-40 ℃) or thermoneutral (19 ℃, n = 10) conditions for 30 d, and controls were pair-fed to eliminate differential feed intake. Heat-stressed wethers were randomly assigned to receive clinical-dose dexamethasone IM injections every 72 h, twice daily fish oil capsule oral boluses, or placebos. Heat stress decreased (P < 0.05) growth and efficiency, but dexamethasone and fish oil supplementation recovered these performance measures. Heat stress also decreased (P < 0.05) predictive body composition metrics that were at least partially improved by administration of dexamethasone and fish oil. Proximate analyses of muscles showed that heat stress decreased (P < 0.05) percentage of protein and increased (P < 0.05) percentage of intramuscular fat, neither of which was improved by dexamethasone or fish oil. Immunohistochemistry revealed that heat stress decreased (P < 0.05) myoblast differentiation and muscle fiber size, but anti-inflammatory supplementation recovered differentiation only. Plasma IGF-1 concentrations were not different among groups throughout the study. These findings demonstrate how heat stress-induced inflammation contributes to impaired growth, efficiency, and body composition observed in heat-stressed feeder lambs. However, targeting inflammation with dexamethasone or fish oil recovers many of these deficits.

The Cooperative …

Evaluation Of Corn Processing Method And Sweet Bran Inclusion On Beef Cattle Performance And Nutrient Digestion And Individual Sweet Bran Components On Nutrient Digestion, Rebecca L. Sjostrand

Department of Animal Science: Dissertations, Theses, and Student Research

One feedlot trial (Exp. 1) and one digestion trial (Exp. 2) were conducted to evaluate the interaction of corn processing method and Sweet Bran inclusion on nutrient digestion, ruminal fermentation parameters, and feedlot performance. In Exp. 1 when no Sweet Bran was fed, cattle fed steam-flaked corn (SFC) had greater ADG, HCW and a 12.4% improvement in feed efficiency compared to cattle fed a high-moisture corn/ dry-rolled corn (HMC/DRC) blend. However, as Sweet Bran increased in the diet to 40%, cattle fed HMC/DRC had greater improvements in ADG and HCW than cattle fed SFC resulting in similar performance at 40% …

Assessment Of The University Of Rhode Island's Dining Halls And Student Perceptions Of On-Campus Dining, Maria Cherry

Senior Honors Projects

University dining halls are understudied food environments that affect student diet quality. This study (1) assessed dining hall offerings at the University of Rhode Island (URI) using the Partnership for a Healthier America’s Healthier Campus Initiative (PAHA) criteria for healthier campus food environments and (2) evaluated student perceptions of the dining hall through a campus-wide survey (n=165). We evaluated breakfast, lunch, and dinner using spring cycle menus (16 weeks in 2019 and 4 in 2021) from two full-service dining halls totaling 29 meals in 2019, and 84 meals in 2021 to determine adherence with PAHA criteria for availability of: 1) …

Assessment Of Soil, Water Contamination And Land Cover Changes In The Urban And Suburban Watersheds Of Houston, Texas, Felica Rena Davis

Dissertations (2016-Present)

Intense urbanization and increased anthropogenic activity are two important factors contributing to the decline of soil and water quality in Houston watersheds, which poses a great environmental and human health risks. This study, therefore, was designed to: 1) determine nutrient and metal concentrations in soil and water samples along Carpenters Bayou (CaB), Cedar Bayou (CB), Sims Bayou (SB), Spring Creek Bayou (SC) and Vince Bayou (VB), 2) analyze land cover changes in watersheds using Landsat image analysis and 3) evaluate socio-economic characteristics and human health risks for each watershed. Soil and water samples were collected from three different locations with …

Utility Of The 13c-Pantoprazole Breath Test As A Cyp2c19 Phenotyping Probe For Children, Keith Feldman, Gregory L. Kearns, Robin E. Pearce, Susan M. Abdel-Rahman, J Steven Leeder, Alec Friesen, Vincent S. Staggs, Andrea Gaedigk, Jaylene Weigel, Valentina Shakhnovich

Manuscripts, Articles, Book Chapters and Other Papers

The 13 C-pantoprazole breath test (PAN-BT) is a safe, noninvasive, in vivo CYP2C19 phenotyping probe for adults. Our objective was to evaluate PAN-BT performance in children, with a focus on discriminating individuals who, according to guidelines from the Clinical Pharmacology Implementation Consortium (CPIC), would benefit from starting dose escalation versus reduction for proton pump inhibitors (PPIs). Children (n = 65, 6-17 years) genotyped for CYP2C19 variants *2, *3, *4, and *17 received a single oral dose of 13 C-pantoprazole. Plasma concentrations of pantoprazole and its metabolites, and changes in exhaled 13 CO2 (termed delta-over-baseline or DOB), were measured 10 times …

Sight Deprivation And Metabolic Effects During The Ymca Bench Press Test, Kyle Cruz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Several studies have investigated the effect of sensory deprivation, particularly sight. However, very few have demonstrated the impact of sight deprivation while exercising to cadence blindfolded. This study aimed to determine exercise performance during a common muscular endurance evaluation, the YMCA Bench Press Test (YBPT), while blindfolded compared to a sighted condition. Twenty-five healthy participants (11 male, 14 female, 168 ± 7.7cm, 68 ± 11.7kg, 23 ± 7.5% fat mass) were recruited from the University of Nevada, Las Vegas student populations and communities. After a YBPT familiarization session, participants completed testing in a counterbalanced order, following the same procedures. A …