Digital Commons Network^™

The Aryl Hydrocarbon Receptor Instructs The Immunomodulatory Profile Of A Subset Of Clec4a4, Wei-Le Wang, Jun Kasamatsu, Satoru Joshita, Susan Gilfillan, Blanda Di Luccia, Santosh K Panda, Do-Hyun Kim, Pritesh Desai, Jennifer K Bando, Stanley Ching-Cheng Huang, Kentaro Yomogida, Steven J Van Dyken, Marina Cella, Marco Colonna, Et Al

Open Access Publications

SignificanceEosinophils contribute to type 2 immunity against helminths and allergens. The small intestine harbors eosinophils with incompletely understood pathophysiological roles. Here, we show that intestinal eosinophils include two subsets. One expresses the inhibitory receptor Clec4a4 and the inhibitory ligand PD-L1 and is unique to the small intestine; the other manifests a proinflammatory phenotype. Both subsets are blood derived. Remarkably, Clec4a4

Cetuximab And Anemia Prevention In Head And Neck Cancer Patients Undergoing Radiotherapy, Lucas G. Maahs, Ahmed I. Ghanem, Radhika Gutta, Amy Tang, Swarn Arya, Zaid Al-Saheli, Haythem Y. Ali, Steven S. Chang, Samantha Tam, Vivian Wu, Farzan Siddiqui, Jawad Z. Sheqwara

Hematology/Oncology Articles

BACKGROUND: Epidermal growth factor receptor (EGFR) activation is associated with increased production of interleukin 6 (IL6), which is intensified by radiotherapy (RT) induced inflammatory response. Elevated IL6 levels intensifies RT-induced anemia by upregulating hepcidin causing functional iron deficiency. Cetuximab, an EGFR inhibitor, has been associated with lower rates of anemia for locally advanced head and neck squamous cell carcinoma (HNSCC). We hypothesized that concomitant cetuximab could prevent RT-induced anemia.

METHODS: We queried our institutional head and neck cancers database for non-metastatic HNSCC cases that received RT with concomitant cetuximab or RT-only between 2006 and 2018. Cetuximab was administered for some …

Grassy–Herbaceous Land Moderates Regional Climate Effects On Honey Bee Colonies In The Northcentral Us, Gabriela M. Quinlan, Douglas Sponsler, Hannah R. Gaines-Day, Harper B G Mcminn-Sauder, Clint R V Otto, Autumn H. Smart, Théotime Colin, Claudio Gratton, Rufus Isaacs, Reed Johnson, Meghan O. Milbrath, Christina M. Grozinger

Department of Entomology: Faculty Publications

The lack of seasonally sustained floral resources (i.e. pollen and nectar) is considered a primary global threat to pollinator health. However, the ability to predict the abundance of flowering resources for pollinators based upon climate, weather, and land cover is difficult due to insufficient monitoring over adequate spatial and temporal scales. Here we use spatiotemporally distributed honey bee hive scales that continuously measure hive weights as a standardized method to assess nectar intake. We analyze late summer colony weight gain as the response variable in a random forest regression model to determine the importance of climate, weather, and land cover …

Serotonin Type 3 Receptor Subunit Gene Polymorphisms Associated With Psychosomatic Symptoms In Irritable Bowel Syndrome: A Multicenter Retrospective Study, Sabrina Berens, Gregory Sayuk, Et Al

2020-Current year OA Pubs

BACKGROUND: Single-nucleotide polymorphisms (SNPs) of the serotonin type 3 receptor subunit (

AIM: To assess the association of

METHODS: In this retrospective study, 623 participants with IBS were recruited from five specialty centers in Germany, Sweden, the United States, the United Kingdom, and Ireland. Depressive, anxiety, and somatization symptoms and sociodemographic characteristics were collected. Four functional SNPs -

RESULTS: Depressive and anxiety symptoms significantly worsened with increasing numbers of minor

CONCLUSION: We have provided the first evidence that

French-Fried Potato Consumption And Energy Balance: A Randomized Controlled Trial, Daniel L Smith, Rebecca L Hanson, Stephanie L Dickinson, Xiwei Chen, Amy M Goss, John B Cleek, W Timothy Garvey, David B Allison

Children’s Nutrition Research Center Staff Publications

Background: Epidemiologic observations suggest increased potato consumption correlates with weight gain, adiposity, and diabetes risk, whereas nut consumption is associated with weight control and metabolic health. Randomized controlled trial (RCT) data indicate humans respond to changes in energy intake in single dietary components and compensate for extra energy consumed.

Objectives: We completed an RCT testing whether increased daily potato consumption influences energy balance [specifically, fat mass (FM)] compared with calorie-matched almond consumption.

Methods: A 30-d RCT of 180 adults prescribed calorie-matched (300 kcal/d, n = 60 participants/group) than consumed 1 of the following: 1) almonds (almond group), 2) French fries …

Temporal Changes In Gastrointestinal Fungi And The Risk Of Autoimmunity During Early Childhood: The Teddy Study, Thomas A Auchtung, Christopher J Stewart, Daniel P Smith, Eric W Triplett, Daniel Agardh, William A Hagopian, Anette G Ziegler, Marian J Rewers, Jin-Xiong She, Jorma Toppari, Åke Lernmark, Beena Akolkar, Jeffrey P Krischer, Kendra Vehik, Jennifer M Auchtung, Nadim J Ajami, Joseph F Petrosino

Faculty, Staff and Students Publications

Fungal infections are a major health problem that often begin in the gastrointestinal tract. Gut microbe interactions in early childhood are critical for proper immune responses, yet there is little known about the development of the fungal population from infancy into childhood. Here, as part of the TEDDY (The Environmental Determinants of Diabetes in the Young) study, we examine stool samples of 888 children from 3 to 48 months and find considerable differences between fungi and bacteria. The metagenomic relative abundance of fungi was extremely low but increased while weaning from milk and formula. Overall fungal diversity remained constant over …

The Aryl Hydrocarbon Receptor Instructs The Immunomodulatory Profile Of A Subset Of Clec4a4 Eosinophils Unique To The Small Intestine, Wei-Le Wang, Jun Kasamatsu, Satoru Joshita, Susan Gilfillan, Blanda Di Luccia, Santosh K Panda, Do-Hyun Kim, Pritesh Desai, Jennifer K Bando, Stanley Ching-Cheng Huang, Kentaro Yomogida, Steven J Van Dyken, Marina Cella, Marco Colonna, Et Al

2020-Current year OA Pubs

C-type lectin domain family 4, member a4 (Clec4a4) is a C-type lectin inhibitory receptor specific for glycans thought to be exclusively expressed on murine CD8α− conventional dendritic cells. Using newly generated Clec4a4-mCherry knock-in mice, we identify a subset of Clec4a4-expressing eosinophils uniquely localized in the small intestine lamina propria. Clec4a4+ eosinophils evinced an immunomodulatory signature, whereas Clec4a4− eosinophils manifested a proinflammatory profile. Clec4a4+ eosinophils expressed high levels of aryl hydrocarbon receptor (Ahr), which drove the expression of Clec4a4 as well as other immunomodulatory features, such as PD-L1. The abundance of Clec4a4+ eosinophils was dependent on dietary AHR ligands, increased with …

Potential Impact Of 2017 American College Of Cardiology/American Heart Association Hypertension Guideline On Contemporary Practice: A Cross-Sectional Analysis From Ncdr Pinnacle Registry, Aliza Hussain, Salim S Virani, Luke Zheng, Ty J Gluckman, William B Borden, Frederick A Masoudi, Thomas M Maddox

2020-Current year OA Pubs

Background Clinical implications of change in the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) guideline on the diagnosis and management of hypertension, compared with recommendations by 2014 expert panel and Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC7), are not known. Methods and Results Using data from the NCDR (National Cardiovascular Data Registry) PINNACLE (Practice Innovation and Clinical Excellence) Registry (January 2013-Decemver 2016), we compared the proportion and clinical characteristics of patients seen in cardiology practices diagnosed with hypertension, recommended antihypertensive treatment, and achieving blood pressure (BP) goals …

The Case Of The Invisible Infringer: Metatags, Trademark Infringement And False Designation Of Origin, Veronica Tucci

Journal of Technology Law & Policy

No abstract provided.

The Effects Of Vitamin D Supplementation On Athletic Performance And Injury Prevention, Amani Adeeb Abushamma

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Vitamin D supplementation has numerous effects on athletic performance and plays a significant role in preventing an athlete’s risk of getting injuries. Vitamin D has an impact on numerous physiological functions such as: bone health, muscle function, inflammatory response, and immune function. An athlete’s bone and muscle health are essential for maximum performance and career success. A bone fracture due to vitamin D deficiency can delay an athlete’s training and ultimately inhibit obtaining a collegiate scholarship and/or contract. A cross sectional study found that more than half of athletic trainers did not view 25-hydroxyvitamin D(25[OH]) testing and vitamin D supplementation …

Experience Life In A Refugee Camp - And Learn How To Help - June 25, Matt Windsor

Browse All News

No abstract provided.

Prevalence And Trends In Gestational Diabetes Mellitus Among Women In The United States, 2006–2017: A Population-Based Study, Tao Zhou, Shan Du, Dianjianyi Sun, Xiang Li, Yoriko Heianza, Gang Hu, Litao Sun, Xiaofang Pei, Xiaoyun Shang, Lu Qi

Population and Public Health Science Faculty Publications

The prevalence of gestational diabetes mellitus (GDM) has increased with the increasing rate of obesity. However, national data on the prevalence and secular trends of GDM during the past decade in the United States are lacking. This study included 37,357 women aged more than 18 years and who had ever been pregnant from the National Health Interview Survey (NHIS). We examined GDM prevalence in 2006, 2016, and 2017, with age-standardized to the US population in 2000. We found that the prevalence of GDM per 100 people increased from 4.6 (95% CI, 4.1–5.1) in 2006 to 8.2 (95% CI, 7.5–8.9) in …

Radical (Re)Positioning Of Students As Cocreators Of Curriculum: A Participatory Action Research Study Of Undergraduate Student-Instructor Partnerships In Online Learning Environments, Kari Eleana Goin

Dissertations and Theses

Undergraduate curriculum is not representative of all students. Course content, language, images, and textbooks often reinforce societal power relations and hierarchies that tend to center white, male, hetero, middle-class, able-bodied identities. When students' varied cultural and linguistic identities are not represented in the curriculum, inadequately represented students are less likely to actively participate, persist, and continue their education. Emerging scholarship indicates that student-instructor cocreation of course syllabi, materials, and/or classroom experiences is a promising practice for increasing representation and responsiveness to student voices, although researchers do not know how the process of cocreation unfolds in asynchronous spaces. Enrollment in undergraduate …

Patricia Carpio Whiting: Women, Environmentalism, And The Oregon Legislature In The 1970s, Kim L. Andrews

Dissertations and Theses

This thesis explores the life of one woman, Patricia Carpio Whiting, during the second half of the twentieth century, in an effort to expand the genre of women and environmental studies. It provides context for Carpio Whiting's accomplishments as an elected official in Oregon by describing her childhood in Chicago and her formative years in California, particularly how growing up Filipino American shaped her as an adult. As such, this thesis engages themes of gender, race, and class in historical scholarship. The thesis focuses on Carpio Whiting's life in Oregon and explores the opportunities and challenges facing women as they …

Relationships Among Aa-Genome Chenopodium Diploids And A Whole-Genome Assembly Of The North American Species, C. Watsonii, Lauren Amillicent Young

Theses and Dissertations

Chenopodium quinoa Willd., an ancient Andean pseudocereal almost exclusively consumed in South America, jumped onto the global stage when Western cultures noted quinoa's advantageous nutritional profile. Quinoa seed's high protein content, nutritionally balanced amino acid profile, low glycemic index, and high fiber, vitamin, and mineral content, make it a highly sought-after 'superfood'. Pitseed goosefoot (C. berlandieri Moq.), a closely related North American species sharing quinoa's genome composition (AABB), grows across the North American continent, inhabiting diverse environments including the saline coastal soils of the Gulf of Texas and the drought-prone regions of the Southwest. Quinoa and pitseed goosefoot, along with …

Identifying Colorectal Cancer Caused By Biallelic Mutyh Pathogenic Variants Using Tumor Mutational Signatures, Peter Georgeson, Yin Cao, Et Al

2020-Current year OA Pubs

Carriers of germline biallelic pathogenic variants in the MUTYH gene have a high risk of colorectal cancer. We test 5649 colorectal cancers to evaluate the discriminatory potential of a tumor mutational signature specific to MUTYH for identifying biallelic carriers and classifying variants of uncertain clinical significance (VUS). Using a tumor and matched germline targeted multi-gene panel approach, our classifier identifies all biallelic MUTYH carriers and all known non-carriers in an independent test set of 3019 colorectal cancers (accuracy = 100% (95% confidence interval 99.87-100%)). All monoallelic MUTYH carriers are classified with the non-MUTYH carriers. The classifier provides evidence for a …

Male Student Experiences In Community-Based Federal Work-Study (Cbfws): Exploring The Relationship Of Cbfws To Academic Performance, Career Readiness, And Social Support, Dustin Krein

USF Tampa Graduate Theses and Dissertations

Federal Work-Study (FWS) is a form of student employment in postsecondary education funded by a student’s financial aid. At the University of South Florida (Tampa campus), in the Community-Based Federal Work-Study (CBFWS) program managed by the Office of Community Engagement and Partnerships (OCEP), there has been a decreasing rate of participation among its male students compared to female students. This study examined the experiences and perspectives of male students in CBFWS at USF. The study was guided by one central research question with three sub-questions: From the perspective of the male student participants, what is their CBFWS experience in relation …

Weight Loss For Overweight And Obese Patients With Prostate Cancer: A Study Protocol Of A Randomised Trial Comparing Clinic-Based Versus Telehealth Delivered Exercise And Nutrition Intervention (The Telex Trial), Daniel A. Galvão, Dennis R. Taaffe, Dickon Hayne, Pedro Lopez, Philippa Lyons-Wall, Colin I. Tang, Suzanne K. Chambers, Amanda Devine, Nigel Spry, Emily Jeffery, Christine Kudiarasu, David Joseph, Robert U. Newton

Research outputs 2022 to 2026

Introduction Obese men with prostate cancer have an increased risk of biochemical recurrence, metastatic disease and mortality. For those undergoing androgen deprivation therapy (ADT), substantial increases in fat mass are observed in the first year of treatment. Recently, we showed that a targeted supervised clinic-based exercise and nutrition intervention can result in a substantial reduction in fat mass with muscle mass preserved in ADT-treated patients. However, the intervention needs to be accessible to all patients and not just those who can access a supervised clinic-based programme. The purpose of this study was to evaluate the efficacy of telehealth delivered compared …

Cognitive, Motor, And Language Assessment In Children With Human Immunodeficiency Virus, Putu Indah Budi Apsari, I Nyoman Supadma, Ketut Dewi Kumara Wati, I Wayan Dharma Artana

Folia Medica Indonesiana

Highlights: • HIV-infected children had lower capute scores than normal children. • HIV child age range 12-24 months almost suffer delayed speech, and were in suspect criteria was founded. Abstract: The cognitive, motor and language aspect of HIV-infected children is an important issue affecting their quality of life. The capute scale, divided into Cat and Clams scores, is commonly used to assess children's cognitive, motor, and language functions. This study assessed Cat and Clams' scores of HIV-infected children. We performed Cat and Clams assessment on 136 children consisting of 68 HIV-infected children and 68 normal children as control aged 0-36 …

Patient Satisfaction, Perception-Expectation Gap, And Costumer Satisfaction Index In Annual Survey 2021 At Dr. Soetomo General Academic Hospital, Cita Rosita Sigit Prakoeswa, Nur Hidayah, Arlina Dewi, Indah Purnamasari, Agus Aan Adriansyah, Amak M. Yaqub

Folia Medica Indonesiana

Highlights: • Customers expectations at Dr. Soetomo General Academic Hospital has a higher quality of service. • The handling of complaints has a low performance on the quality of services at Dr. Soetomo General Academic Hospital. • Improving service quality requires improvements in efficient complaint handling. Abstract: Service quality is essential in health institutions that can affect patient satisfaction and loyalty. The growth in the number of patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, triggered the diversification of services that require periodic quality control. This study aimed to investigate the performance of 31 departments/units in the hospital, the …

Managing Human Resources For Surge Capacity In Referral Hospitals Based On Who Hospital Readiness Checklist For Covid-19, Fitri Dinia, Laksono Trisnantoro, Mochamat Helmi

Folia Medica Indonesiana

Highlights: • Managing human resources for surge capacity in three referral hospital at West Kalimantan was evaluated. • Availability, mobilization and recruitment, duties division, and hospital staff welfare are the reasons for referral hospitals in West Kalimantan are not optimal to face surge capacity during the Covid-19 pandemic. • Provincial Health Office role had not been optimal in the HR management at referral hospitals during the Covid-19 pandemic. Abstract: One of the components of effective disaster response management to deal with surge capacity in referral hospitals in West Kalimantan, Indonesia, was to ensure the adequacy of the number of human …

Re:Connection: Exercises In Unplugging And Mindfully Reconnecting, E. J. Roseman

Masters Theses

How can architecture encourage focused attention and mindfulness in an increasingly distracted and distractible world? As a primary means of connectivity in the 21st century, smartphones and social media have provided unparalleled efficiencies, connectivity and entertainment. However, constant engagement with richly-pixelated virtual worlds has also brought about mass addiction to devices as college students log more compulsive “screen time” than ever before. Mental health issues such as crippling anxiety, diminished attention spans, and unhappiness, are on the rise as students disconnect from the physical world and are consumed by their virtual one.

This thesis is comprised of a series of …

The Cost Of Living In Larger Primate Groups Includes Higher Fly Densities, Jan F. Gogarten, Mueena Jahan, Sébastien Calvignac-Spencer, Colin A. Chapman, Tony L. Goldberg, Fabian H. Leendertz, Jessica M. Rothman

Publications and Research

Flies are implicated in carrying and mechanically transmitting many primate pathogens. We investigated how fly associations vary across six monkey species (Cercopithecus ascanius, Cercopithecus mitis, Colobus guereza, Lophocebus albigena, Papio anubis, and Piliocolobus tephrosceles) and whether monkey group size impacts fly densities. Fly densities were generally higher inside groups than outside them, and considering data from these primate species together revealed that larger groups harbored more flies. Within species, this pattern was strongest for colobine monkeys, and we speculate this might be due to their smaller home ranges, suggesting that movement patterns may influence fly–primate associations. Fly associations increase with …

Breaking | Grounding | Growing: Expanding The Rhode Island Gardening Reentry Programs As A Pathway Towards Stability, Juliana Soltys

Masters Theses

What happens to the over two million people incarcerated in U.S. prisons and jails?

Changing in sentencing laws and policies have created a cycle of imprisonment, racially isolating and oppressing BIPOC communities. Reintegration and reentry programs are an avenue to break the cycle of recidivism. Through my work, I have developed hands-on, structured opportunities for justice-involved adults to rebuild a life for themselves by increasing the accessibility of gardening reentry programs. This project creates a space for mentorship and support for Rhode Island’s formerly incarcerated people with the goal of helping them to develop vital life skills through growing and …

System As A Living Organism, Xinyi Liu

Masters Theses

This is cross-disciplinary research in urban systems, architecture, bio-systems, agriculture, energy supplies, circular economy, and sustainability.

Farming Publics: Use Farming Practices As A Tool To De-Alienate People With Land, Sirui Wang

Masters Theses

Historically, farming was the primary way people interacted with the land. Colonialism, industrialization, and capitalism have made people increasingly detached and alienated from nature and the land. The return to agriculture has the potential to play an essential role in resisting the increasing monoculture of our society through re-establishing the kinship toward land. The rising public awareness of sustainability makes the market for organic food expand every year and allures capitalism to manipulate the organic market from its original purpose into their familiar realm of the conventional food system for maximum profit. The market economy, which is controlled by capitalism, …

Regenerating The Ground: Using Regenerative Agricultural Practices To Increase Urban Food Production And Restore The Health Of Soils, Yuxiao Liao

Masters Theses

New England is blessed with a mosaic of productive agricultural landscapes. These agricultural landscapes also sustain valuable wildlife habitats, provide flood control and act as an enormous carbon sink. Farmland in New England declined significantly in the 20th century as agricultural land was abandoned and developed into urban and suburban sprawl. In 1930 there were about 14 billion acres of farmland, by 2017, there were only 4 billion acres left. New England lost almost 70% of farmland in the past 80 years. John Dobberstein has claimed that due to our current development and agricultural practices, there are only 60 harvests …

Bee Stations: Refueling Bees And Creating Opportunities For Education, Jinghan Zhou

Masters Theses

Commercial honey bees are transported between pollinated crops and play an essential role in our agricultural system. This thesis proposes a network of bee stations and corridors that could improve the health of transported bee populations, increase local beekeeping, and help educate the public about the importance of bees and pollinators. The bee stations have at least 100 acres of diversified high-quality wildflower species where trucks that transport bees can stop to “refuel” their hives. The bee stations also have an education center where the public can walk through the wildflower fields, observe bees, make beehives, and learn how to …

Fertilizer Waste Mistreatment Facilities: Investigating The Barrier That Keep Waste In And Attention Out At Central Florida's Phosphogypsum Stacks., Harsha Devaraj

Masters Theses

This project investigates the physical and narrative barriers constructed by the phosphate mining and processing industry to dissuade public engagement with its phosphogypsum sites in Central Florida, USA. The barriers around PG utilize decades of misinformation, racial geographies, and misrepresentations of scale, origin, and risk to create powerful narratives about how we should imagine and relate to these materials. These barriers hinder sustained public attention to their sites, enabling extractive industries to expand while avoiding oversight and responsibility. Attention to how these barriers around phosphogypsum are constructed allows us to recognize these strategies at work in how we see and …

Connect: Translating Complexity Through Visual Simplification, Ilhee Park

Masters Theses

CONNECT: Translating Complexity through Visual Simplification brings complex data into concise visual systems that encourage ease of access. With a background in Human Factors Engineering, user engagement remains a central focus in my design. Whether reducing barriers to scientific information or untangling deeply complex data, design must contain intuitive concepts without the need for extended explanation. Using bold color and geometric shapes as the core design language to render pictorial narratives, this thesis maps my development as an information designer through modes of gathering, deciphering, and interpreting.