Digital Commons Network^™

Effect Of Musculature On Mortality, A Retrospective Cohort Study, Amy L Shaver, Mary E Platek, Anurag K Singh, Sung Jun Ma, Mark Farrugia, Gregory Wilding, Andrew D Ray, Heather M Ochs-Balcom, Katia Noyes

Department of Medical Oncology Faculty Papers

Background: While often life-saving, treatment for head and neck cancer (HNC) can be debilitating resulting in unplanned hospitalization. Hospitalizations in cancer patients may disrupt treatment and result in poor outcomes. Pre-treatment muscle quality and quantity ascertained through diagnostic imaging may help identify patients at high risk of poor outcomes early. The primary objective of this study was to determine if pre-treatment musculature was associated with all-cause mortality.

Methods: Patient demographic and clinical characteristics were abstracted from the cancer center electronic database (n = 403). Musculature was ascertained from pre-treatment CT scans. Propensity score matching was utilized to adjust for confounding …

Monocarboxylate Transporter 4 In Cancer-Associated Fibroblasts Is A Driver Of Aggressiveness In Aerodigestive Tract Cancers, Marina Domingo-Vidal, Diana Whitaker Menezes, Mehri Mollaee, Zhao Lin, Madalina Tuluc, Nancy J. Philp, Jennifer Johnson, Tingting Zhan, Joseph Curry, Ubaldo E. Martinez-Outshoorn

Department of Medical Oncology Faculty Papers

The most common cancers of the aerodigestive tract (ADT) are non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC). The tumor stroma plays an important role in ADT cancer development and progression, and contributes to the metabolic heterogeneity of tumors. Cancer-associated fibroblasts (CAFs) are the most abundant cell type in the tumor stroma of ADT cancers and exert pro-tumorigenic functions. Metabolically, glycolytic CAFs support the energy needs of oxidative (OXPHOS) carcinoma cells. Upregulation of the monocarboxylate transporter 4 (MCT4) and downregulation of isocitrate dehydrogenase 3α (IDH3α) are markers of glycolysis in CAFs, and upregulation of the …

Vitamin D Treatment Prevents Uremia-Induced Reductions In Aortic Microrna-145 Attenuating Osteogenic Differentiation Despite Hyperphosphatemia, Natalia Carrillo-López, Sara Panizo, Maria Vittoria Arcidiacono, Sandra De La Fuente, Laura Martínez-Arias, Emerenziana Ottaviano, Catalina Ulloa, María Piedad Ruiz-Torres, Isabel Rodríguez, Jorge B Cannata-Andía, Manuel Naves-Díaz, Adriana S Dusso

2020-Current year OA Pubs

In chronic kidney disease, systemic inflammation and high serum phosphate (P) promote the de-differentiation of vascular smooth muscle cells (VSMC) to osteoblast-like cells, increasing the propensity for medial calcification and cardiovascular mortality. Vascular microRNA-145 (miR-145) content is essential to maintain VSMC contractile phenotype. Because vitamin D induces aortic miR-145, uremia and high serum P reduce it and miR-145 directly targets osteogenic osterix in osteoblasts, this study evaluated a potential causal link between vascular miR-145 reductions and osterix-driven osteogenic differentiation and its counter-regulation by vitamin D. Studies in aortic rings from normal rats and in the rat aortic VSMC line A7r5 …

Spillover Effects In Product Customization, Samuel Babu Sekar

USF Tampa Graduate Theses and Dissertations

Product customization is increasingly being offered as consumers interact with businesses online. When consumers customize a product, they often choose from among multiple, inter-related categories. Thus, the choices made in a prior category could influence choices in later categories (spillover effect). Currently, marketers attempt to nudge consumers to choose more expensive/profitable options by preselecting these options (explicit reference). In this dissertation, I explore whether implicit references can be employed to generate a spillover effect. Implicit references are generated by arranging the options within a category in either descending or ascending price order, with descending price order favoring the selection of …

The Effects Of Resistance Training On Physical Fitness And Neuromotor-Cognitive Functions In Adults With Down Syndrome, Emily M. Post, William J. Kraemer, Madison L. Kackley, Lydia K. Caldwell, Jeff S. Volek, Barbara N. Sanchez, Brian C. Focht, Robert U. Newton, Keijo Häkkinen, Carl M. Maresh

Health and Sport Sciences Faculty Scholarship

Adults with Down syndrome are an underserved population at high risk for a host of different pathologies from aging and lack of activity.

Purpose: To examine the effects of a 10-week resistance training program on measures of motor behavior, cognitive function, mood, and physical fitness.

Methods: Participants (n = 11) were men and women clinically diagnosed with Down syndrome (age: 25.8 ± 6.4 years; height: 151.5 ± 8.3 cm; weight: 67.5 ± 13.0 kg; IQ: 58.3 ± 19.7 units). After familiarization of testing procedures, subjects performed The Arizona Cognitive Test Battery for Down Syndrome, TGMD-2, lower and upper body …

2022 June 21 - Medical Student Education Committee Annual Meeting Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Space Bioprocess Engineering On The Horizon, Aaron J. Berliner, Isaac Lipsky, Davian Ho, Jacob M. Hilzinger, Gretchen Vengerova, Georgios Makrygiorgos, Matthew J. Mcnulty, Kevin Yates, Nils J. H. Averesch, Charles S. Cockell, Tyler Wallentine, Lance C. Seefeldt, Craig S. Criddle, Somen Nandi, Karen A. Mcdonald, Amor A. Menezes, Ali Mesbah, Adam P. Arkin

Chemistry and Biochemistry Faculty Publications

Space bioprocess engineering (SBE) is an emerging multi-disciplinary field to design, realize, and manage biologically-driven technologies specifically with the goal of supporting life on long term space missions. SBE considers synthetic biology and bioprocess engineering under the extreme constraints of the conditions of space. A coherent strategy for the long term development of this field is lacking. In this Perspective, we describe the need for an expanded mandate to explore biotechnological needs of the future missions. We then identify several key parameters—metrics, deployment, and training—which together form a pathway towards the successful development and implementation of SBE technologies of the …

Psychosocial Considerations For The Child With Rare Disease: A Review With Recommendations And Calls To Action., Leslee Belzer, Margaret Wright, Emily J. Goodwin, Mehar N. Singh, Brian S. Carter

Manuscripts, Articles, Book Chapters and Other Papers

Rare diseases (RD) affect children, adolescents, and their families infrequently, but with a significant impact. The diagnostic odyssey undertaken as part of having a child with RD is immense and carries with it practical, emotional, relational, and contextual issues that are not well understood. Children with RD often have chronic and complex medical conditions requiring a complicated milieu of care by numerous clinical caregivers. They may feel isolated and may feel stigmas in settings of education, employment, and the workplace, or a lack a social support or understanding. Some parents report facing similar loneliness amidst a veritable medicalization of their …

The Effectiveness Of Governmental Policy Measures On Controlling The Spread Of Covid-19: Empirical Evidence From Around The World, Lobna Abdallah Yassin

Theses and Dissertations

The rapid spread of COVID-19 in China and the world dramatically affected the development in China and many countries worldwide. Different governments applied various policy measures to control the virus and prevent its spreading inside their countries. These policy measures combined with this global health crisis have serious consequences on the health system in different countries and the world economy. This thesis aims to quantitatively measure the effectiveness of the governmental policy measures that are taken during the risk management of the coronavirus across different countries on controlling the spread of the virus. Also, this thesis highlights the different policies …

Smartphone Apps For Diabetes Medication Adherence: Systematic Review, Sheikh Mohammed Shariful Islam, Vinaytosh Mishra, Muhammad U Siddiqui, Jeban Chandir Moses, Sasan Adibi, Lemai Nguyen, Nilmini Wickramasinghe

Division of Internal Medicine Faculty Papers & Presentations

Background: Diabetes is one of the leading noncommunicable chronic diseases globally. In people with diabetes, blood glucose levels need to be monitored regularly and managed adequately through healthy lifestyles and medications. However, various factors contribute to poor medication adherence. Smartphone apps can improve medication adherence in people with diabetes, but it is not clear which app features are most beneficial.

Objective: This study aims to systematically review and evaluate high-quality apps for diabetes medication adherence, which are freely available to the public in Android and Apple app stores and present the technical features of the apps.

Methods: We systematically searched …

Dedicated To Health Disparities Research, Nicholas Gosling

UNH Today Archive

No abstract provided.

A Telehealth-Delivered Tai Chi Intervention (Taichi4joint) For Managing Aromatase Inhibitor-Induced Arthralgia In Patients With Breast Cancer During Covid-19: Longitudinal Pilot Study, Sameh Gomaa, Carly West, Ana Maria Lopez, Tingting Zhan, Max Schnoll, Maysa Abu-Khalaf, Andrew B. Newberg, Kuang-Yi Wen

Department of Medical Oncology Faculty Papers

Background: Estrogen receptor-positive breast cancer is the most common type of breast cancer in postmenopausal women. Aromatase inhibitors (AIs) are the endocrine therapy of choice recommended for these patients. Up to 50% of those treated with an AI develop arthralgia, often resulting in poor adherence and decreased quality of life.

Objective: The study is a single-arm longitudinal pilot study aiming to evaluate the safety, feasibility, acceptability, and potential efficacy of TaiChi4Joint, a remotely delivered 12-week tai chi intervention designed to relieve AI-induced joint pain.

Methods: Women diagnosed with stage 0-III breast cancer who received an AI for at least 2 …

Integrated Screens Uncover A Cell Surface Tumor Suppressor Gene Kirrel Involved In Hippo Pathway, Chao Wang, Xu Feng, Dan Su, Zhen Chen, Shimin Wang, Mengfan Tang, Min Huang, Litong Nie, Huimin Zhang, Siting Li, Ling Yin, Randy L Johnson, Traver Hart, Junjie Chen

Faculty, Staff and Student Publications

Cell surface proteins play essential roles in various biological processes and are highly related to cancer development. They also serve as important markers for cell identity and targets for pharmacological intervention. Despite their great potentials in biomedical research, comprehensive functional analysis of cell surface proteins remains scarce. Here, with a de novo designed library targeting cell surface proteins, we performed in vivo CRISPR screens to evaluate the effects of cell surface proteins on tumor survival and proliferation. We found that

Market Animal Feed Efficiency: A Tool For Evaluating Feed Conversion, Cody Zesiger, Jessie Hadfield, Jacob Hadfield, Joshua Dallin

All Current Publications

The market animal feed efficiency calculator is designed to help youth livestock producers become more profitable and improve market animal feed efficiency.

Ceramide-1-Phosphate: A Novel Regulator Of Golgi Fragmentation, Golgi-Er Vesicle Trafficking, And Anaplasma Phagocytophilum Pathogenesis, Anika Nayar Ali

USF Tampa Graduate Theses and Dissertations

Anaplasma phagocytophilum, the etiologic agent of human granulocytic anaplasmosis (HGA), is a tick transmitted obligate intracellular bacterium that infects granulocytes, bone marrow progenitor cells and endothelial cells. HGA exhibits symptoms of febrile illness including fever, chills, headache, malaise, leukopenia and elevated liver enzymes which are treatable by antibiotics. However, elderly and immunocompromised patients are at a greater risk of developing fatal complications. Inside the host cell A.phagocytophilum resides in host cell derived vacuole called A.phagocytophilum occupied vacuole (ApV) where it undergoes its biphasic lifecycle. Being an intracellular pathogen, A.phagocytophilum relies heavily on nutrient acquisition from host cell and to obtain …

Effect Of Post-Activation Potentiation On The Force, Power And Rate Of Power And Force Development Of The Upper Limbs In Mixed Martial Arts (Mma) Fighters, Taking Into Account Training Experience, Alan Langer, Angelina Ignatieva, Patricia Fischerova, Magdalena Nitychoruk, Artur Gołaś, Adam Maszczyk

Baltic Journal of Health and Physical Activity

Introduction. The aim of the study is to determine the optimal load for generating the highest value of force, power and the rate of power and force development (RFD and RPD) in the upper limb of mixed martial arts (MMA) fighters with the use of activation and explosive exercises. The training period of MMA players was included in the research. Material and Methods: Twenty-nine MMA fighters participated in the study and were divided into two groups depending on the length of their training period (under and over 5 years). The subjects did 2 ballistic push-ups before the study and after-wards …

The Effect Of Caffeine On Countermovement Jump Performance In Recreationally Trained Women Habituated To Caffeine, Dawid Gawel, Magdalena Kaszuba, Zuzanna Komarek, Robert Krawczyk, Marta Bichowska, Marcin Jasinski, Robert Trybulski

Baltic Journal of Health and Physical Activity

Introduction. The main goal of this study was to examine the effect of acute intake of 3 mg/kg/body mass (b.m.) of caffeine (CAF) on countermovement jump (CMJ) performance in recreationally trained women habituated to CAF. Material and Methods. 17 healthy recreationally trained women habitually using CAF participated in the study. The experiment followed randomized, cross-over, double-blind design under three different conditions: control test (CONT) or consumed placebo (PLAC) or consumed 3 mg/kg/b.m. of CAF (CAF-3). Each participant performed 2 sets of 2 CMJ. The following variables were recorded: concentric peak velocity (PV), peak power (PP) and jump height (JH). Results. …

What’S In Your Glass? Whether Milk Labels Should Be Based On Creation Process Or End Product (Part I Of Iii), Samantha Masters

Law Review Blog Posts

This blog series analyzes the product-versus-process debate of bio-identical dairy products through the lens of the cultured meat industry and proposes a framework for milk labeling regulation.

How Much Further Can Southern Resilience Go?, Abbie-Noel Pittman

Venture: The University of Mississippi Undergraduate Research Journal

Climate change affects everyone. However, the Southeastern United States is at a higher risk of negative effects. The South is especially vulnerable to climate change not because mitigation will drain resources, but because those resources were never available in the first place. This paper describes the geographic disadvantages of the Southeastern United States and explains how prior institutional inequality will exacerbate those disadvantages for marginalized groups and communities. The South depends on agriculture and tourism economically, both of which are heavily climate dependent. For southerners who already lack resources, the destruction of two main job industries would be detrimental. This …

Evaluating Behavioral Skills Training To Teach Identification Of Choking Hazards To Substitute Caregivers, Madison L. Molve

USF Tampa Graduate Theses and Dissertations

Choking is a leading cause of mortality in children (Committee on Injury, Violence and Poison Prevention, 2010). Over half of choking injuries occur due to food, and the remaining injuries involve common household objects (Chapin et al., 2013). Although studies have been conducted assessing the use of Behavioral Skills Training (BST) to teach hazard identification in substitute caregivers (Abarca, 2021), no studies have evaluated utilizing BST to identify choking hazards specifically. Thus, this study evaluated the efficacy of using BST to teach edible and non-edible choking hazard identification to substitute caregivers following guidelines from the Home Accident Prevention Inventory Revised …

Prevalence Of Entamoeba Histolytica In Human From Baghdad City, Lina A. Jebur, Athmar K. Abbas

Al-Esraa University College Journal for Medical Sciences

The result of microscopic examination of 100 human stool samples showed that 33% of them were infected with Entamoeba histolytica. The rate of infection with Entamoeba histolytica in the males was 21% while in the females was 12% with a significant differences at (P6-10 years, while the lowest rate 4% was found at age group ≥20 years. The highest infection rate 54.54% occurred in July/2021, while, the lowest 18.18% was reported in January and February/2021 with significant differences at (P

Anemia And Associated Risk Factors Among Pregnant Women In Al Karkh Health Directorate, Baghdad / Iraq, Fawzi Hashim Atshan, Ibtisam Faraj Hasan

Al-Esraa University College Journal for Medical Sciences

Introduction: Anemia in pregnancy is one of the most common public health problems in developing country,it is commonly associated with poor pregnancy outcome and can result in complications that threaten the life of both mother and fetus. The main risk factors associated with anemia during pregnancy are low body storage of iron ,low intake of iron, poor absorption of iron from diet, chronic infections, and parasitic diseases . Objective: To determine the prevalence of anemia and associated risk factors among pregnant women attending antenatal care units in Baghdad Al Karkh Heath Directorate, Baghdad/Iraq . Materials and Methods: Descriptive cross-sectional study, …

Vitamin D Deficiency, Its Relation To Bone, Back Pain, Tiredness And Mood Improving In Adult Sample Collected From Baghdad City, Abass T. Al Joudi, Mohammed Raad Khalaf

Al-Esraa University College Journal for Medical Sciences

Vitamin D deficiency is a global health problem. With all the medicall advances of the century, vitamin D deficiency is still prevailing. Over a billion people worldwide are Vitamin D deficient or insufficient. In this study data collected from 58 outpatients Clinic from Bagdad citw/Iraq, suffering from Vitamin D deficiency at different rate. They were either suffer from Vitamin D deficiency (10-19) ng/ml, insufficient (20-29) ng/ml or some sutfer with sever deficiency< 10ng/ml. This study covered random samples of different gender (male and female) and from different life style, which include different symptoms (bone and back pain, tiredness, hair loss and mood improving). Results showed that women were more accessible than men for Vitamin D deficiency due to woman loss more Vitamin Dthrough menopause, pregnancy and lactation period and results showed that patients with age (40 to 59) year old and (60 to 69) year old were suffering from bone and back bone pain, were 25% of the sample study were suffering from hair loss. Most people covered in this study were felling tiredness and headache. Inthisstudy samplescollected from patients with Vitamin D deficiencies were treated by giving dosages of supplement medicine (like Cholecalciferoll and Colecaliciferol) to optimize level of 25-OH Vitamin D3. To increase Vitamin D rate in these patients. Results also showed that the supplement medicine help and improve reducing hair loss, bone and back pain within two months of taken it, were 25% of the sample study suffering from felling tiredness and headache which they start to recovered their health gradually after taken medication within first and second month of treatment. In relation to depression, it was concluded that depression was associated with low Vitamin D level in patients' especially old peoples and from the results, medical supplement found to be improves mood and reduce depression in a sample of people study especially in women.

A Highly Effective Natural Herbal Mixture That Helps To Normalize The Sugar Level For People With Chronic Diabetes, Isam Shaker Hamza, Aziz Latif Jarallah, Tariq Yaseen Mahmoud

Al-Esraa University College Journal for Medical Sciences

The effect of a herbal mixture consisting of (Portulaca oleracea seeds or the so-called berberine, Curcuma, Lepidium sativum seeds and Trigonella) was investi- gated as a treatment for high blood sugar. Three groups of twenty mice were used in each of these groups. The first part of this investigation was to study the chemical properties of these herbs mixture and appeared to us that this herbal mixture con- tain the following chemicals Saponins, Alkaloids, Flavonoids, Glycosides, Tannins in different proportions. The second part of the investigation concentrated on prepar- ing three groups of mice each with 20 mouse. The first …

Marine Ranching Version 3.0: History, Status And Prospects, Hongsheng Yang, Dewen Ding

Bulletin of Chinese Academy of Sciences (Chinese Version)

Since the 1930s, the construction of marine ranching has successively experienced the version 1.0 (traditional marine ranching) of farming-ranching and engineering, and the version 2.0 (marine ecological ranching) of ecologization and informatization, and now it is about to enter the version 3.0 (global aquatic ecological ranching) of digitalization and systematization, which covers seawater and fresh water. Marine ranching version 3.0 must adhere to the modern aquatic ecological ranching development concept of "ecology, precision, intelligence, integration", characterized by synchronous protection and utilization, expansion of scene and space, breakthrough in core technology, and innovation in development patterns. After establishing the whole industrial …

Association Of Plasma Neurofilament Light Chain With Glycaemic Control And Insulin Resistance In Middle-Aged Adults, Rohith N. Thota, Pratishtha Chatterjee, Steve Pedrini, Eugene Hone, Jessica J. A. Ferguson, Manohar L. Garg, Ralph N. Martins

Research outputs 2022 to 2026

Aims: This study aimed to determine the association of plasma neurofilament light (NfL), a marker of neurodegeneration, with diabetes status and glycaemic parameters in people with normal glycaemia (NG), pre-diabetes (PD) and type 2 diabetes (T2D). Methods: Clinical and descriptive data for the diagnostic groups, NG (n=30), PD (n=48) and T2D (n=29), aged between 40 and 75 years were included in this cross-sectional analysis. Plasma NfL levels were analyzed using the ultra-sensitive single-molecule array (Simoa) platform. Results: A positive correlation was evident between plasma NfL and fasting glucose (r = 0.2824; p = 0.0032). Plasma NfL levels were not correlated …

Effectiveness Of Nurse-Led Volunteer Support And Technology-Driven Pain Assessment In Improving The Outcomes Of Hospitalised Older Adults: Protocol For A Cluster Randomised Controlled Trial, Rosemary Saunders, Kate Crookes, Karla Seaman, Seng Giap Marcus Ang, Caroline Bulsara, Max K. Bulsara, Beverley Ewens, Olivia Gallagher, Renee M. Graham, Karen Gullick, Sue Haydon, Jeff Hughes, Mustafa Atee, Kim Huong Nguyen, Bev O'Connell, Debra Scaini, Christopher Etherton-Beer

Research outputs 2022 to 2026

Introduction:

Hospitalised older adults are prone to functional deterioration, which is more evident in frail older patients and can be further exacerbated by pain. Two interventions that have the potential to prevent progression of frailty and improve patient outcomes in hospitalised older adults but have yet to be subject to clinical trials are nurse-led volunteer support and technology-driven assessment of pain.

Methods and Analysis:

This single-centre, prospective, non-blinded, cluster randomised controlled trial will compare the efficacy of nurse-led volunteer support, technology-driven pain assessment and the combination of the two interventions to usual care for hospitalised older adults. Prior to commencing …

Outcomes Of A Telehealth Adaptation Of A Trauma-Based Parent Training Program, Holland Hayford

USF Tampa Graduate Theses and Dissertations

Approximately 25% of children will experience a traumatic event by the age of four. If trauma symptoms remain untreated, these traumatic experiences during early childhood can negatively impact a child’s executive functioning skills, mental health, social interactions, and relational attachments to other individuals. Due to the harmful impact of untreated trauma symptoms on children’s wellbeing and development, several evidence-based interventions have been developed. One such intervention is Smart Start: Parenting Tools for Children with Developmental Delay, Social-Emotional Concerns, and Trauma (version 5), which targets children’s disruptive behaviors and trauma symptoms, caregivers’ parenting stress, and the caregiver-child relationship. This study utilized …

Promoting Cancer Health Equity: A Qualitative Study Of Mentee And Mentor Perspectives Of A Training Program For Underrepresented Scholars In Cancer Health Disparities, Anastasia Rogova, Isabel Martinez Leal, Maggie Britton, Shine Chang, Kamisha H Escoto, Kayce D Solari Williams, Crystal Roberson, Lorna H Mcneill, Lorraine R Reitzel

Faculty, Staff and Student Publications

Racial and ethnic minorities, and women, experience stark disparities in cancer risk behaviors and mortality rates, yet often remain underrepresented in scientific research positions. We conducted an exploratory, qualitative study to examine the value of mentored research experience as part of an NCI-funded research training program designed to increase the representation of minority and women scientists in cancer disparities research. Using individual interviews, we explored 16 mentees' and 7 mentors' program experiences and perspectives to identify the most effective strategies to build strong mentoring relationships that could ultimately contribute to increased representation in health disparities research. Two expert analysts employed …

Identifying The Geographic Origins Of Invasive Megathyrsus Maximus In The United States Using Molecular Data, John F. Gaskin, John A. Goolsby, Marie Claude Bon, Massimo Cristofaro, Paul André Calatayud

All Peer-Reviewed Publications

Megathyrsus maximus is nonnative in the neotropics, with a tall form that is commonly used as a forage grass and a smaller-statured form that is considered invasive in south Texas, USA. Biological control researchers are challenged to find an agent that will attack the short form, but not the desirable tall form in other parts of the neotropics. We conducted molecular analyses on 155 Megathyrsus maximus samples from its native range in Africa and compared them with U.S. short-form samples to help determine the geographic origins of its invasion. We found eight distinct genotypes in 34 short-form samples from Texas …