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Articles 42271 - 42300 of 240433
Full-Text Articles in Entire DC Network
Highlights From The 67th Annual Meeting Of The American Society For Artificial Internal Organs In Chicago, Il, Christopher D. Pritting, Alice L. Sweedo, Vakhtang Tchantchaleishvili, Dongfang Wang, Joseph B. Zwischenberger
Highlights From The 67th Annual Meeting Of The American Society For Artificial Internal Organs In Chicago, Il, Christopher D. Pritting, Alice L. Sweedo, Vakhtang Tchantchaleishvili, Dongfang Wang, Joseph B. Zwischenberger
Department of Surgery Faculty Papers
Dr. Willem J. Kolff founded the American Society for Artificial Internal Organs (ASAIO) in 1955. Each year experts in the fields of renal, pulmonary, pancreatic, cardiac, bioengineering, and orthopedic research congregate to discuss the latest developments in their respective fields. Throughout the conference's history, ASAIO has adapted to promote inquiry, ingenuity, and innovation. The congeniality partnered with the expertise of the conference's attendees has facilitated continuous progress since the conference's inception.
The 2022 ASAIO Annual Conference was held in Chicago, IL in an entirely in-person format, the first since the 65th conference in 2019. This year there were exhibits by …
Readiness, Response, And Recovery: The Impacts Of Covid-19 On Education Systems In Asia, Anna Dabrowski, Yung Nietschke, Syeda Kashfee Ahmed, Amy Berry, Maya Conway
Readiness, Response, And Recovery: The Impacts Of Covid-19 On Education Systems In Asia, Anna Dabrowski, Yung Nietschke, Syeda Kashfee Ahmed, Amy Berry, Maya Conway
Monitoring Learning
This review provides insights into COVID-19 responses in educational systems in Asia, and to understand which policies and practices were already in place to contribute to system readiness and resilience. Although the evidence base remains scarce, reflecting on the different system and school-level responses in Asia provides opportunity to identify gaps in current policies and research, and consider new ways in which countries in Asia can strengthen their educational systems into the future. It considers what makes an education system resilient, and the importance of school level practices. It uses an analytical framework to review readiness, response and recovery, and …
The International Academy Of Language And Culture: The Global (Pre)K-12 Charter School Network, Dree-El Simmons
The International Academy Of Language And Culture: The Global (Pre)K-12 Charter School Network, Dree-El Simmons
Dissertations, Theses, and Capstone Projects
The International Academy of Language and Culture (IALC) is a charter school based on the original concept of charter schools by Ray Budde and Albert Shanker, as an academic environment dedicated and designed to improving the educational outcomes for its students through innovative pedagogy. Committed to American (and global) education reform, the IALC incorporates elements from higher education into the early childhood and adolescent settings. We accomplish this by utilizing an interdisciplinary approach in our language and culture-based program.
The IALC is a multilingual, full-immersion program. Food Studies (including culinary arts), the Arts, the Humanities, Social Sciences, and Martial Arts …
Efficacy, Acceptance, And Feasibility Of Virtual Reality For Chronic Pain Relief In Older Adult Veterans Residing In Long Term Care, Valicia Philibert
Efficacy, Acceptance, And Feasibility Of Virtual Reality For Chronic Pain Relief In Older Adult Veterans Residing In Long Term Care, Valicia Philibert
Dissertations, Theses, and Capstone Projects
Older adults residing in Long-Term Care (LTC) have a high prevalence of chronic pain. Pain management strategies have primarily focused on pharmacological approaches, but with physiological changes associated with aging, this population is at an increased risk for adverse effects from prescribed medications. More research is needed on innovative non-pharmacological interventions in the LTC setting. This study examined the feasibility, acceptance, and preliminary efficacy of Virtual Reality (VR) for chronic pain among older adult veterans in LTC. In this quasi-experimental, 12 older adult participants living with chronic pain in a long-term care facility received two sessions of VR. Pain intensity …
Generation Of Mycobacterium Smegmatis Model Systems For Testing Inhibitors Of The Mycobactin Siderophore Of Mycobacterium Tuberculosis, Gabrielle A. Germain
Generation Of Mycobacterium Smegmatis Model Systems For Testing Inhibitors Of The Mycobactin Siderophore Of Mycobacterium Tuberculosis, Gabrielle A. Germain
Dissertations, Theses, and Capstone Projects
Mycobacterium tuberculosis (Mtb) is the pathogenic bacterium causative of tuberculosis. According to the 2021 World Health Organization (WHO) Global Tuberculosis (TB) Report, there were approximately 5.8 million TB cases in 2020, and 1.3 million TB deaths among HIV negative people in that year. The rise of multi-drug resistant Mtb strains has increased the need for more potent microbials against this pathogen. Biosynthesis of iron scavenging molecules, known as siderophores (e.g., mycobactin and carboxymycobactin), has been identified as a potential drug target candidate since iron acquisition has been directly linked to the survival and virulence of Mtb. Salicyl-AMS (Sal-AMS) is …
Katharine Bement Davis: Defying Expectations As A Woman And In The Study Of Women, Ella Hester
Katharine Bement Davis: Defying Expectations As A Woman And In The Study Of Women, Ella Hester
Dissertations, Theses, and Capstone Projects
Katharine Bement Davis’ (1860-1935) life and career as a highly educated scientist and Progressive activist placed her at the forefront of various moral panic debates at the turn of the twentieth century. Davis was born into a staunch abolitionist and suffragist family in upstate New York in 1860. Her family’s politics were grounded in progressive Protestant principles which allowed her to gain access to higher education as a white woman from a middle-class family. Her education left her poised to use the latest scientific research to shape Progressive dogma in the 1910s and 1920s. Davis’ education and the groundbreaking research …
Aging On Parole: An Empirical Analysis Of Reentry, Reintegration, And Life Satisfaction, Angela Silletti Murolo
Aging On Parole: An Empirical Analysis Of Reentry, Reintegration, And Life Satisfaction, Angela Silletti Murolo
Dissertations, Theses, and Capstone Projects
As the prison population grays, so too does the people leaving prison. In New Jersey and New York, 35% and 26% of people on parole are over the age of 50 respectively. While older persons have lower recidivism rates compared to younger persons, there are physical, mental, and societal challenges that come with advancing age that can make reentry and reintegration a particularly difficult experience compared to younger persons. The aim of this dissertation is to explore the experiences of older adults on parole and the parole officers that assist them in their reentry and reintegration.
This study is unique …
Novel Food Ingredients: Food Safety Law, Animal Testing, And Consumer Perspectives, Taimie Bryant
Novel Food Ingredients: Food Safety Law, Animal Testing, And Consumer Perspectives, Taimie Bryant
Marquette Law Review
In recent years, some major food companies have publicly stated that they will no longer test their product ingredients on animals. Yet despite the availability of more reliably predictive non-animal toxicity tests, some companies continue testing novel food ingredients on animals. This Article uses the lens of a particular innovative plant-based food company’s decision to test a novel food ingredient on animals as a means of considering more generally whether any food producer has rational legal reasons for testing on animals. The Article explores FDA requirements, consumer food safety litigation, and judicial evaluation of animal test data, all of which …
The Relationship Among Barring Pattern, Feather Growth Rates, And Age, In The Carolina Wren, David A. Cimprich
The Relationship Among Barring Pattern, Feather Growth Rates, And Age, In The Carolina Wren, David A. Cimprich
North American Bird Bander
No abstract provided.
Full Issue 14(4) 2022
Journal of Comparative & International Higher Education
No abstract provided.
Screening Families In Primary Care For Social And Economic Needs: Patients’ Urgency And Activation For Social Care Navigation, Sarah D. Ronis, Marie Masotya, Kurt C. Stange
Screening Families In Primary Care For Social And Economic Needs: Patients’ Urgency And Activation For Social Care Navigation, Sarah D. Ronis, Marie Masotya, Kurt C. Stange
Faculty Scholarship
Introduction: Social determinants of health (SDoH) screening and intervention in primary care aim to alleviate adverse influences on health, but its efficacy may be diluted when offered supports are not well matched to families’ desire for such services. The purpose of this prospective cohort study was to provide guidance to social care navigation teams regarding which families would be most likely to make use of services. Methods: Analysis of registry data collected in April 1–September 30, 2021 from a social care navigation program embedded in a medical home was conducted. Multivariable regression models explored (1) whether family-reported urgency of needs, …
Patch-Burn Grazing Impacts Forage Resources In Subtropical Humid Grazing Lands, Elizabeth H. Boughton, Nuria Gomez-Casanovas, Hilary Swain, Carl Bernacchi, Raoul K. Boughton, Keith Brinsko, Haoyu Li, Alan Rivero, Evan H. Delucia, Jed Sparks
Patch-Burn Grazing Impacts Forage Resources In Subtropical Humid Grazing Lands, Elizabeth H. Boughton, Nuria Gomez-Casanovas, Hilary Swain, Carl Bernacchi, Raoul K. Boughton, Keith Brinsko, Haoyu Li, Alan Rivero, Evan H. Delucia, Jed Sparks
United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications
Subtropical humid grazing lands represent a large global land use and are important for livestock production, as well as supplying multiple ecosystem services. Patch-burn grazing (PBG) management is applied in temperate grazing lands to enhance environmental and economic sustainability; however, this management system has not been widely tested in subtropical humid grazing lands. The objective of this study was to determine how PBG affected forage resources, in comparison with the business-as-usual full-burn (FB) management in both intensively managed pastures (IMP) and seminative (SN) pastures in subtropical humid grazinglands. We hypothesized that PBG management would create patch contrasts in forage quantity …
Evaluation Of The Control Of Water Sanitation And Hygiene Related Disease Through Community Hygiene Club Intervention In Rwanda, Amans Ntakarutimana, Elias Nyandwi, Nadine Rujeni, Chantal Marie Ingabire Dr, Kato Jonas Njunwa, Théoneste Ntakirutimana, Gaspard Rwanyiziri, Joseph Tuyishimire, Schaddrack Ngabonziza
Evaluation Of The Control Of Water Sanitation And Hygiene Related Disease Through Community Hygiene Club Intervention In Rwanda, Amans Ntakarutimana, Elias Nyandwi, Nadine Rujeni, Chantal Marie Ingabire Dr, Kato Jonas Njunwa, Théoneste Ntakirutimana, Gaspard Rwanyiziri, Joseph Tuyishimire, Schaddrack Ngabonziza
Journal of Social, Behavioral, and Health Sciences
This article consists of a review article reporting the results of previous evaluations of the control of water, sanitation, and hygiene (WASH) related disease through the Community Hygiene Club (CHC) intervention from 2010 to 2020. CHC constitutes the main intervention for the control of WASH-related disease in Rwanda and is implemented countrywide. The study objective was to evaluate if the CHC intervention significantly reduced the prevalence of WASH-related disease after 10 years of its implementation in Rwanda. The study utilized online existing policy documents, research reports, and experiences on the CHC intervention in Rwanda published between 2010 and 2020. We …
Pgc-1Α Overexpression Is Not Sufficient To Mitigate Cancer Cachexia In Either Male Or Female Mice, Francielly Morena Da Silva, Megan Rosa-Caldwell, Eleanor R. Schrems, Lauren Martinez, Madeline G. Amos, Seongkyun Lim, Ana Regina Cabrera, Jacob L. Brown, Tyrone A. Washington, Nicholas P. Greene
Pgc-1Α Overexpression Is Not Sufficient To Mitigate Cancer Cachexia In Either Male Or Female Mice, Francielly Morena Da Silva, Megan Rosa-Caldwell, Eleanor R. Schrems, Lauren Martinez, Madeline G. Amos, Seongkyun Lim, Ana Regina Cabrera, Jacob L. Brown, Tyrone A. Washington, Nicholas P. Greene
Health, Human Performance and Recreation Faculty Publications and Presentations
Cancer cachexia (CC) accounts for 20%–40% of cancer-related deaths. Mitochondrial aberrations have been shown to precede muscle atrophy in different atrophy models, including cancer. Therefore, this study investigated potential protection from the cachectic phenotype through overexpression of peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1α). First, to establish potential of mitochondria-based approaches we showed that the mitochondrial antioxidant MitoTEMPO (MitoT) attenuates myotube atrophy induced by Lewis lung carcinoma (LLC) cell conditioned media. Next, cachexia was induced in muscle-specific PGC-1α overexpressing (MCK-PCG1α) or wildtype (WT) littermate mice by LLC implantation. MCK-PCG1α did not protect LLC-induced muscle mass loss. In plantaris, Atrogin mRNA …
Impact Of Immigration Parent-Child Separation Policies On Children’S Attachment Experiences, Daisy Casasnovas
Impact Of Immigration Parent-Child Separation Policies On Children’S Attachment Experiences, Daisy Casasnovas
Dissertations
This critical literature review (CRP) project explores the consequences of child-parent separation by deportation laws. Considering the number of Latinx immigrant families immigrating to the United States, this review focused on how the unexpected separation by deportation impacted immigrant families and how these separations affect their children’s development, attachment style, and overall well-being. The review explored the short- and long-term consequences for immigrant children and their families, including children who are U.S.-born and remain in the country without their parents. Results from the review indicate an extensive and significant impact on attachment style and overall developmental impairments. The unexpected separation …
Who Makes New Recommendations For Ebola Treatments, Calls For Improved Access
Who Makes New Recommendations For Ebola Treatments, Calls For Improved Access
Saudi Medical Journal
No abstract provided.
Research On A Suitable Upstream Traceability Model For The Natural Rubber Supply Chain In Thailand, Specifically For Rib-Smoke-Sheet (Rss), Beh Kok Fong
Dissertations and Theses Collection (Open Access)
Traceability is the first step to gain visibility in the supply chain and can be used to meet different purposes. Similar to other agriculture crops, the natural rubber industry faces reputational damage due to deforestation, land grab, loss of biodiversity and non-compliance with environmental standards occurring in the upstream. The introduction of new social and environmental regulations accelerates the need for traceability. Reflecting on the importance of environmental and social considerations, this industry is looking at traceability to identify the historical trends leading to the present sustainability state and any ongoing sustainability risks in the upstream to enable downstream users …
Development Of A Structural Model For The Adoption Of Industry 4.0 Enabled Sustainable Operations For Operational Excellence, Sumit Gupta, Basai Prathipati, Govind Sharan Dangayach, Posinasetti Nageswara Rao, Sandeep Jagtap
Development Of A Structural Model For The Adoption Of Industry 4.0 Enabled Sustainable Operations For Operational Excellence, Sumit Gupta, Basai Prathipati, Govind Sharan Dangayach, Posinasetti Nageswara Rao, Sandeep Jagtap
Faculty Publications
In the current competitive scenario, SMEs need to adopt advanced technology in order to comprehend the dynamics of Industry 4.0 and the sustainable operations for operational excellence. The present study discusses the relationship between Industry 4.0 with sustainable operations and operational excellence. A research model is proposed and assessed through structural equation modelling (SEM). The current research shows that if SMEs adopt Industry 4.0 practices and the use of advanced robotics in order to minimize human intervention, as well as smart logistics that react to changes in production capacity, virtual reality and dynamic simulation techniques, then SMEs can significantly achieve …
Preparation Of Cellulose Acetate Nanocomposite Films Based On Tio2-Zno Nanoparticles Modification As Food Packaging Applications, Hajer Ali, Nahida Hameed
Preparation Of Cellulose Acetate Nanocomposite Films Based On Tio2-Zno Nanoparticles Modification As Food Packaging Applications, Hajer Ali, Nahida Hameed
Journal of Applied Sciences and Nanotechnology
To develop bio-packaging materials, nanocomposite films of cellulose acetate reinforced with titanium dioxide and zinc oxide nanoparticles were prepared, by the casting method at different weight ratios of ZnO nanoparticles (1.5, 2, and 2.5) wt% and a constant weight ratio of 2 wt% TiO2. ZnO and TiO2 nanoparticles were tested using scanning electron microscopy (SEM). The mechanical properties (tensile strength and elongation) were improved at a fixed level of Cellulose Acetate+ 2% TiO2+1.5wt% ZnO loading. Beyond that level of loading, they decreased. The tensile strength was decreased due to some degrees of agglomeration of filler particles above a critical content. …
Chth 514.X01: Health And Culture, Gilbert A. Quintero
Chth 514.X01: Health And Culture, Gilbert A. Quintero
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Pubh 380.01: Public Health Nutrition, Blakely D. Brown
Pubh 380.01: Public Health Nutrition, Blakely D. Brown
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Risk Of Type 2 Diabetes Among Individuals With Excess Weight: Weight Trajectory Effects, Arthur H Owora, David B Allison, Xuan Zhang, Nana Gletsu-Miller, Kishore M Gadde
Risk Of Type 2 Diabetes Among Individuals With Excess Weight: Weight Trajectory Effects, Arthur H Owora, David B Allison, Xuan Zhang, Nana Gletsu-Miller, Kishore M Gadde
Children’s Nutrition Research Center Staff Publications
PURPOSE OF REVIEW: Increased risk of type 2 diabetes mellitus (T2D) among individuals with overweight or obesity is well-established; however, questions remain about the temporal dynamics of weight change (gain or loss) on the natural course of T2D in this at-risk population. Existing epidemiologic evidence is limited to studies that discretely sample and assess excess weight and T2D risk at different ages with limited follow-up, yet changes in weight may have time-varying and possibly non-linear effects on T2D risk. Predicting the impact of weight change on the risk of T2D is key to informing primary prevention. We critically review the …
The Associations Between Relative And Absolute Body Mass Index With Mortality Rate Based On Predictions From Stigma Theory, Gregory Pavela, Nengjun Yi, Luis Mestre, Stella Lartey, Pengcheng Xun, David B Allison
The Associations Between Relative And Absolute Body Mass Index With Mortality Rate Based On Predictions From Stigma Theory, Gregory Pavela, Nengjun Yi, Luis Mestre, Stella Lartey, Pengcheng Xun, David B Allison
Children’s Nutrition Research Center Staff Publications
Background: The social consequences of obesity may influence health and mortality rate (MR), given obesity's status as a highly stigmatized condition. Hence, a high absolute body mass index (BMI) in conjunction with the stigmatization of a high BMI may each independently increase the rate of MR.
Objectives: We tested whether relative BMI, defined as ordinal rank within a social reference group jointly defined by age, sex, and race/ethnicity, is associated with MR independent of absolute BMI.
Methods: Data were from three nationally representative datasets: the Health and Retirement Study (n = 31,115), the National Health Interview Survey (NHIS, n = …
Redox-Engineering Enhances Maize Thermotolerance And Grain Yield In The Field, Stuart A Sprague, Tej Man Tamang, Trevor Steiner, Qingyu Wu, Ying Hu, Tayebeh Kakeshpour, Jungeun Park, Jian Yang, Zhao Peng, Blake Bergkamp, Impa Somayanda, Morgan Peterson, Ely Oliveira Garcia, Yangfan Hao, Paul St Amand, Guihua Bai, Paul A Nakata, Ivo Rieu, David P Jackson, Ninghui Cheng, Barbara Valent, Kendal D Hirschi, Sv Krishna Jagadish, Sanzhen Liu, Frank F White, Sunghun Park
Redox-Engineering Enhances Maize Thermotolerance And Grain Yield In The Field, Stuart A Sprague, Tej Man Tamang, Trevor Steiner, Qingyu Wu, Ying Hu, Tayebeh Kakeshpour, Jungeun Park, Jian Yang, Zhao Peng, Blake Bergkamp, Impa Somayanda, Morgan Peterson, Ely Oliveira Garcia, Yangfan Hao, Paul St Amand, Guihua Bai, Paul A Nakata, Ivo Rieu, David P Jackson, Ninghui Cheng, Barbara Valent, Kendal D Hirschi, Sv Krishna Jagadish, Sanzhen Liu, Frank F White, Sunghun Park
Children’s Nutrition Research Center Staff Publications
Increasing populations and temperatures are expected to escalate food demands beyond production capacities, and the development of maize lines with better performance under heat stress is desirable. Here, we report that constitutive ectopic expression of a heterologous glutaredoxin S17 from Arabidopsis thaliana (AtGRXS17) can provide thermotolerance in maize through enhanced chaperone activity and modulation of heat stress-associated gene expression. The thermotolerant maize lines had increased protection against protein damage and yielded a sixfold increase in grain production in comparison to the non-transgenic counterparts under heat stress field conditions. The maize lines also displayed thermotolerance in the reproductive stages, resulting in …
Tennessee Farm Bureau News - September 2022, Tennessee Farm Bureau Federation
Tennessee Farm Bureau News - September 2022, Tennessee Farm Bureau Federation
Tennessee Farm Bureau News
No abstract provided.
Genome-Wide Association Analyses Of Physical Activity And Sedentary Behavior Provide Insights Into Underlying Mechanisms And Roles In Disease Prevention, Zhe Wang, Andrew Emmerich, Nicolas J Pillon, Tim Moore, Daiane Hemerich, Marilyn C Cornelis, Eugenia Mazzaferro, Siacia Broos, Tarunveer S Ahluwalia, Traci M Bartz, Amy R Bentley, Lawrence F Bielak, Mike Chong, Audrey Y Chu, Diane Berry, Rajkumar Dorajoo, Nicole D Dueker, Elisa Kasbohm, Bjarke Feenstra, Mary F Feitosa, Christian Gieger, Mariaelisa Graff, Leanne M Hall, Toomas Haller, Fernando P Hartwig, David A Hillis, Ville Huikari, Nancy Heard-Costa, Christina Holzapfel, Anne U Jackson, Åsa Johansson, Anja Moltke Jørgensen, Marika A Kaakinen, Robert Karlsson, Kathleen F Kerr, Boram Kim, Chantal M Koolhaas, Zoltan Kutalik, Vasiliki Lagou, Penelope A Lind, Mattias Lorentzon, Leo-Pekka Lyytikäinen, Massimo Mangino, Christoph Metzendorf, Kristine R Monroe, Alexander Pacolet, Louis Pérusse, Rene Pool, Rebecca C Richmond, Natalia V Rivera, Sebastien Robiou-Du-Pont, Katharina E Schraut, Christina-Alexandra Schulz, Heather M Stringham, Toshiko Tanaka, Alexander Teumer, Constance Turman, Peter J Van Der Most, Mathias Vanmunster, Frank J A Van Rooij, Jana V Van Vliet-Ostaptchouk, Xiaoshuai Zhang, Jing-Hua Zhao, Wei Zhao, Zhanna Balkhiyarova, Marie N Balslev-Harder, Sebastian E Baumeister, John Beilby, John Blangero, Dorret I Boomsma, Soren Brage, Peter S Braund, Jennifer A Brody, Marcel Bruinenberg, Ulf Ekelund, Ching-Ti Liu, John W Cole, Francis S Collins, L Adrienne Cupples, Tõnu Esko, Stefan Enroth, Jessica D Faul, Lindsay Fernandez-Rhodes, Alison E Fohner, Oscar H Franco, Tessel E Galesloot, Scott D Gordon, Niels Grarup, Catharina A Hartman, Gerardo Heiss, Jennie Hui, Thomas Illig, Russell Jago, Alan James, Peter K Joshi, Taeyeong Jung, Mika Kähönen, Tuomas O Kilpeläinen, Woon-Puay Koh, Ivana Kolcic, Peter P Kraft, Johanna Kuusisto, Lenore J Launer, Aihua Li, Allan Linneberg, Jian'an Luan, Pedro Marques Vidal, Sarah E Medland, Yuri Milaneschi, Arden Moscati, Bill Musk, Christopher P Nelson, Ilja M Nolte, Nancy L Pedersen, Annette Peters, Patricia A Peyser, Christine Power, Olli T Raitakari, Mägi Reedik, Alex P Reiner, Paul M Ridker, Igor Rudan, Kathy Ryan, Mark A Sarzynski, Laura J Scott, Robert A Scott, Stephen Sidney, Kristin Siggeirsdottir, Albert V Smith, Jennifer A Smith, Emily Sonestedt, Marin Strøm, E Shyong Tai, Koon K Teo, Barbara Thorand, Anke Tönjes, Angelo Tremblay, Andre G Uitterlinden, Jagadish Vangipurapu, Natasja Van Schoor, Uwe Völker, Gonneke Willemsen, Kayleen Williams, Quenna Wong, Huichun Xu, Kristin L Young, Jian Min Yuan, M Carola Zillikens, Alan B Zonderman, Adam Ameur, Stefania Bandinelli, Joshua C Bis, Michael Boehnke, Claude Bouchard, Daniel I Chasman, George Davey Smith, Eco J C De Geus, Louise Deldicque, Marcus Dörr, Michele K Evans, Luigi Ferrucci, Myriam Fornage, Caroline Fox, Theodore Garland, Vilmundur Gudnason, Ulf Gyllensten, Torben Hansen, Caroline Hayward, Bernardo L Horta, Elina Hyppönen, Marjo-Riitta Jarvelin, W Craig Johnson, Sharon L R Kardia, Lambertus A Kiemeney, Markku Laakso, Claudia Langenberg, Terho Lehtimäki, Loic Le Marchand, Patrik K E Magnusson, Nicholas G Martin, Mads Melbye, Andres Metspalu, David Meyre, Kari E North, Claes Ohlsson, Albertine J Oldehinkel, Marju Orho-Melander, Guillaume Pare, Taesung Park, Oluf Pedersen, Brenda W J H Penninx, Tune H Pers, Ozren Polasek, Inga Prokopenko, Charles N Rotimi, Nilesh J Samani, Xueling Sim, Harold Snieder, Thorkild I A Sørensen, Tim D Spector, Nicholas J Timpson, Rob M Van Dam, Nathalie Van Der Velde, Cornelia M Van Duijn, Peter Vollenweider, Henry Völzke, Trudy Voortman, Gérard Waeber, Nicholas J Wareham, David R Weir, Heinz-Erich Wichmann, James F Wilson, Andrea L Hevener, Anna Krook, Juleen R Zierath, Martine A I Thomis, Ruth J F Loos, Marcel Den Hoed
Genome-Wide Association Analyses Of Physical Activity And Sedentary Behavior Provide Insights Into Underlying Mechanisms And Roles In Disease Prevention, Zhe Wang, Andrew Emmerich, Nicolas J Pillon, Tim Moore, Daiane Hemerich, Marilyn C Cornelis, Eugenia Mazzaferro, Siacia Broos, Tarunveer S Ahluwalia, Traci M Bartz, Amy R Bentley, Lawrence F Bielak, Mike Chong, Audrey Y Chu, Diane Berry, Rajkumar Dorajoo, Nicole D Dueker, Elisa Kasbohm, Bjarke Feenstra, Mary F Feitosa, Christian Gieger, Mariaelisa Graff, Leanne M Hall, Toomas Haller, Fernando P Hartwig, David A Hillis, Ville Huikari, Nancy Heard-Costa, Christina Holzapfel, Anne U Jackson, Åsa Johansson, Anja Moltke Jørgensen, Marika A Kaakinen, Robert Karlsson, Kathleen F Kerr, Boram Kim, Chantal M Koolhaas, Zoltan Kutalik, Vasiliki Lagou, Penelope A Lind, Mattias Lorentzon, Leo-Pekka Lyytikäinen, Massimo Mangino, Christoph Metzendorf, Kristine R Monroe, Alexander Pacolet, Louis Pérusse, Rene Pool, Rebecca C Richmond, Natalia V Rivera, Sebastien Robiou-Du-Pont, Katharina E Schraut, Christina-Alexandra Schulz, Heather M Stringham, Toshiko Tanaka, Alexander Teumer, Constance Turman, Peter J Van Der Most, Mathias Vanmunster, Frank J A Van Rooij, Jana V Van Vliet-Ostaptchouk, Xiaoshuai Zhang, Jing-Hua Zhao, Wei Zhao, Zhanna Balkhiyarova, Marie N Balslev-Harder, Sebastian E Baumeister, John Beilby, John Blangero, Dorret I Boomsma, Soren Brage, Peter S Braund, Jennifer A Brody, Marcel Bruinenberg, Ulf Ekelund, Ching-Ti Liu, John W Cole, Francis S Collins, L Adrienne Cupples, Tõnu Esko, Stefan Enroth, Jessica D Faul, Lindsay Fernandez-Rhodes, Alison E Fohner, Oscar H Franco, Tessel E Galesloot, Scott D Gordon, Niels Grarup, Catharina A Hartman, Gerardo Heiss, Jennie Hui, Thomas Illig, Russell Jago, Alan James, Peter K Joshi, Taeyeong Jung, Mika Kähönen, Tuomas O Kilpeläinen, Woon-Puay Koh, Ivana Kolcic, Peter P Kraft, Johanna Kuusisto, Lenore J Launer, Aihua Li, Allan Linneberg, Jian'an Luan, Pedro Marques Vidal, Sarah E Medland, Yuri Milaneschi, Arden Moscati, Bill Musk, Christopher P Nelson, Ilja M Nolte, Nancy L Pedersen, Annette Peters, Patricia A Peyser, Christine Power, Olli T Raitakari, Mägi Reedik, Alex P Reiner, Paul M Ridker, Igor Rudan, Kathy Ryan, Mark A Sarzynski, Laura J Scott, Robert A Scott, Stephen Sidney, Kristin Siggeirsdottir, Albert V Smith, Jennifer A Smith, Emily Sonestedt, Marin Strøm, E Shyong Tai, Koon K Teo, Barbara Thorand, Anke Tönjes, Angelo Tremblay, Andre G Uitterlinden, Jagadish Vangipurapu, Natasja Van Schoor, Uwe Völker, Gonneke Willemsen, Kayleen Williams, Quenna Wong, Huichun Xu, Kristin L Young, Jian Min Yuan, M Carola Zillikens, Alan B Zonderman, Adam Ameur, Stefania Bandinelli, Joshua C Bis, Michael Boehnke, Claude Bouchard, Daniel I Chasman, George Davey Smith, Eco J C De Geus, Louise Deldicque, Marcus Dörr, Michele K Evans, Luigi Ferrucci, Myriam Fornage, Caroline Fox, Theodore Garland, Vilmundur Gudnason, Ulf Gyllensten, Torben Hansen, Caroline Hayward, Bernardo L Horta, Elina Hyppönen, Marjo-Riitta Jarvelin, W Craig Johnson, Sharon L R Kardia, Lambertus A Kiemeney, Markku Laakso, Claudia Langenberg, Terho Lehtimäki, Loic Le Marchand, Patrik K E Magnusson, Nicholas G Martin, Mads Melbye, Andres Metspalu, David Meyre, Kari E North, Claes Ohlsson, Albertine J Oldehinkel, Marju Orho-Melander, Guillaume Pare, Taesung Park, Oluf Pedersen, Brenda W J H Penninx, Tune H Pers, Ozren Polasek, Inga Prokopenko, Charles N Rotimi, Nilesh J Samani, Xueling Sim, Harold Snieder, Thorkild I A Sørensen, Tim D Spector, Nicholas J Timpson, Rob M Van Dam, Nathalie Van Der Velde, Cornelia M Van Duijn, Peter Vollenweider, Henry Völzke, Trudy Voortman, Gérard Waeber, Nicholas J Wareham, David R Weir, Heinz-Erich Wichmann, James F Wilson, Andrea L Hevener, Anna Krook, Juleen R Zierath, Martine A I Thomis, Ruth J F Loos, Marcel Den Hoed
Faculty, Staff and Student Publications
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle …
Presence Of Malnutrition And Severe Acute Malnutrition Among Children In South Asia, Madison Johnson
Presence Of Malnutrition And Severe Acute Malnutrition Among Children In South Asia, Madison Johnson
Ballard Brief
South Asia is home to 23% of the global population and has the largest prevalence of stunting in any region in the world. Severe acute malnutrition is a frequent cause of death in children under 5 globally. While sustainable development goals have brought more people out of poverty in the last 50 years, a disproportionate number of children remain malnourished. These children are typically found in developing countries, with a large burden existing in South Asia. Young children are most susceptible to the effects of malnutrition as they are at a stage of increased physical and cognitive development. There are …
Environmental Justice For Food System Workers: Heat-Illness Prevention Standards As One Step Toward Just Transition, Sarah A. Matsumoto
Environmental Justice For Food System Workers: Heat-Illness Prevention Standards As One Step Toward Just Transition, Sarah A. Matsumoto
Publications
No abstract provided.
Exploring The Impact Of Health Worker Strikes On Maternal And Child Health In A Kenyan County, Abdu Mohiddin, Eva Langat, James Orwa, Violet Naanyu, Marleen Temmerman
Exploring The Impact Of Health Worker Strikes On Maternal And Child Health In A Kenyan County, Abdu Mohiddin, Eva Langat, James Orwa, Violet Naanyu, Marleen Temmerman
Obstetrics and Gynaecology, East Africa
Background: Studies of the impact of health care workers’ strikes tend to look at facility-level activity rather than populations, with evidence from low and middle-income countries relatively sparse. This study explored the effect of national strikes on maternal and child health. It looked at the impact on health system activity in both public and non-public sectors (e.g. private, faith-based), on health promotion investments like immunisation, and on disease detection like post-partum haemorrhage (PPH). A 100 day doctors’ strike started in December 2016, a 150 day nurses strike from June 2017 and then the clinical officers for 21 days that …
Repurposing Epigenetic Inhibitors To Target The Clostridioides Difficile-Specific Dna Adenine Methyltransferase And Sporulation Regulator Cama, Jujun Zhou, John R Horton, Dan Yu, Ren Ren, Robert M Blumenthal, Xing Zhang, Xiaodong Cheng
Repurposing Epigenetic Inhibitors To Target The Clostridioides Difficile-Specific Dna Adenine Methyltransferase And Sporulation Regulator Cama, Jujun Zhou, John R Horton, Dan Yu, Ren Ren, Robert M Blumenthal, Xing Zhang, Xiaodong Cheng
Faculty, Staff and Student Publications
Epigenetically targeted therapeutic development, particularly for SAM-dependent methylations of DNA, mRNA and histones has been proceeding rapidly for cancer treatments over the past few years. However, this approach has barely begun to be exploited for developing new antibiotics, despite an overwhelming global need to counter antimicrobial resistance. Here, we explore whether SAM analogues, some of which are in (pre)clinical studies as inhibitors of human epigenetic enzymes, can also inhibit Clostridioides difficile-specific DNA adenine methyltransferase (CamA), a sporulation regulator present in all C. difficile genomes sequenced to date, but found in almost no other bacteria. We found that SGC0946 (an …