Digital Commons Network^™

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Burden Of Cardiovascular Disease In Pakistan – Insight From Global Burden Of Disease Study 2019, Ali Bin Jabbar, Taha Mansoor, Sana Sheikh, Tazeen Jafar, Sawera Hanif, Christian Razo, Mahboob Alam, Jamal Rana, Khurram Nasir, Salim Virani

Population Health, East Africa

Background Pakistan, currently the fifth-largest country by population globally, has experienced a population increase of over 100% since 1990. It is facing an escalating challenge from cardiovascular diseases (CVD). The Global Burden of Disease (GBD) 2019 study provides an in-depth evaluation of Pakistan's health situation since 1990, offering essential insights into the nation's overall health conditions.

Methods The data were obtained from the Global Burden of Disease Study 2019, which provides records for global, regional, and national burden of diseases. Specifically, data regarding CVD and its subtypes, morbidity, and mortality in Pakistan and globally from 1990 to 2019 were used …

Weight Loss And Chronic Rhinosinusitis In The Obese Population: Associations With Disease Risk And Burden, Zain Mehdi, Akshay R Prabhakar, Jagan M R Dwarampudi, Justina R Varghese, Heli Majeethia, Faizaan Khan, Roshan Dongre, Franklin M Wu, Aatin Dhanda, Sebastian Guadarrama-Sistos-Vazquez, Tania Banerjee, Renjie Hu, Amber U Luong, Dennis M Tang, Edward D Mccoul, Mohammad Chaaban, Masayoshi Takashima, Omar G Ahmed

Faculty, Staff and Student Publications

Objective: Obesity is associated with increased risk and severity of chronic rhinosinusitis (CRS), yet the impact of weight loss (WL) on CRS development and burden is not well defined. This study investigates whether weight reduction influences the likelihood of developing CRS and improves clinical outcomes among obese adults.

Methods: Retrospective cohort study using the NIH All of Us database. Obese adults (BMI ≥ 30) with complete demographics and follow-up were included. To assess CRS onset, patients were stratified into sequential WL cohorts and followed for 1 year. To assess CRS outcomes, patients who lost ≥ 5 BMI points were categorized …

Growth Failure And Early Recurrence In Congenital Diaphragmatic Hernia: An International Cohort Study, Rachel C Bordelon, Kylie I Holden, Charles C Miller, Ashley H Ebanks, Kevin P Lally, Matthew T Harting, Allison L Speer, Representing The Congenital Diaphragmatic Hernia Study Group

Faculty, Staff and Student Publications

Purpose: The primary objective was to determine whether growth failure (GF) is associated with early recurrence in congenital diaphragmatic hernia (CDH). The secondary objective was to characterize the prevalence and severity of GF in CDH survivors.

Background: GF is common among CDH survivors, yet it is unclear how growth challenges affect overall morbidity, including hernia recurrence. CDH-specific nutritional guidelines include high calorie and protein targets during periods of acute illness but may benefit from clarifying the relationship between growth and adverse outcomes in this population.

Methods: This multicenter cohort study retrospectively analyzed prospectively collected data from the CDH Study Group …

A Topic Modeling Analysis Of Stigma Dimensions, Social, And Related Behavioral Circumstances In Clinical Notes Among Patients With Hiv, Ziyi Chen, Yiyang Liu, Mattia Prosperi, Krishna Vaddiparti, Robert L Cook, Jiang Bian, Yi Guo, Yonghui Wu

Faculty, Staff and Student Publications

Objective: To characterize stigma dimensions, social, and related behavioral circumstances in people living with HIV (PLWHs) seeking care, using natural language processing methods applied to a large collection of electronic health record (EHR) clinical notes from a large integrated health system in the southeast United States.

Methods: We identified a cohort of PLWHs from the University of Florida (UF) Health Integrated Data Repository and performed topic modeling analysis using Latent Dirichlet Allocation (LDA) to uncover stigma-related dimensions and related social and behavioral contexts. Domain experts created a seed list of HIV-related stigma keywords, then applied a snowball strategy to iteratively …

A Treat-To-Target Approach For Obesity Management: A Post Hoc Analysis Of The Surmount-5 Trial., Carel W Le Roux, Luca Busetto, Louis Aronne, Deborah Bade Horn, Georgios K Dimitriadis, Beverly Falcon, Luis-Emilio Garcia-Perez, Elisa Gomez Valderas, Theresa Hunter Gibble, Cagri Senyucel, Julia P Dunn

Faculty, Staff and Student Publications

Introduction: With new advancements in obesity medicine, clarity on goals and expectations for successful disease management is limited. This post hoc analysis assessed application of proposed treat-to-target (TtT) thresholds for obesity to the outcome measures of SURMOUNT-5, which randomised participants with obesity to tirzepatide or semaglutide.

Methods: The proportion of participants in each treatment group reaching proposed TtT thresholds for waist to height ratio (WHtR) < 0.53, body mass index (BMI) < 27 kg/m2, or a combination was evaluated. The associations between the thresholds and achieving low disease activity to remission (meeting goals for at least four of five defined cardiometabolic risk parameters) and normalisation or improvement in SF-36v2 physical component score (PCS) from baseline to week 72 were explored.

Results: About 23.1%-33.9% of participants treated with tirzepatide and 14.2%-20.7% treated with semaglutide reached the TtT thresholds, with greater weight reduction than the overall population. About 77% of participants who reached WHtR < 0.53 achieved low disease activity to remission, with an odds ratio of 2.31 (p < 0.001) compared to those who did not reach this target. The BMI threshold was not statistically associated with the assessed outcomes for SF-36v2 PCS.

Conclusion: In this …

Eating For Healthy Eyes: The Role Of Nutrition In Ocular Health, Brianna Stroh

Honors Program: Senior Projects (Public)

The central research question of this thesis asks: How does nutrition influence ocular health overall and the impact of nutrition on the development or progression of common eye diseases? Building upon existing research in optometry/ophthalmology, nutrition science, and public health, this project examines the physiological mechanisms linking diet to eye health and evaluates how specific nutrients and dietary patterns contribute to disease prevention and visual function. This thesis employs a comprehensive review of peer-reviewed literature to evaluate the relationship between nutrition and ocular disease. Key areas of focus include the role of oxidative stress in eye disease development, the protective …

Initial Site Of Metastasis Influences Prognosis In Pancreatic Ductal Adenocarcinoma, Eleanor Mancheski, David Baek, Wilbur Bowne, Harish Lavu, Charles Yeo, Avinoam Nevler

Department of Surgery Faculty Papers

INTRODUCTION: Metastatic pancreatic ductal adenocarcinoma (mPDAC) is a highly aggressive malignancy. Prior studies suggest that the initial site of metastasis may impact prognosis. This study investigates whether overall survival in mPDAC patients differs between patients first presenting with lung metastases versus those presenting with liver metastases.

METHODS: This retrospective analysis utilized the multi-institutional TriNetX database, identifying patients with histologically diagnosed PDAC who initially presented with either liver or lung metastases. Demographic, histologic, and outcome data were collected and analyzed. Patients were matched 1:1 using a nearest neighbor propensity score (PS) algorithm, and Kaplan-Meier survival analyses were performed. Cox regression was …

Nh Guide To 4-H Dog Shows, Extension

UNH Cooperative Extension

No abstract provided.

A Supervised, Online, Home-Based Eccentric Resistance Exercise Program For Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease, Kedar S. Deshpande, Nosaka, Aus Molan, Isaac S. Raj, John K. Olynyk, Oyekoya T. Ayonrinded

Research outputs 2022 to 2026

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common non-communicable chronic liver disease worldwide, increasing long-term risk of cirrhosis, type 2 diabetes mellitus, and cardiovascular diseases. Although reducing liver steatosis by increasing physical activity can lower these risks, patients with MASLD often struggle to exercise regularly. We examined the effects of a supervised, home-based, online bodyweight eccentric exercise program on liver and metabolic markers, and physical fitness in patients with MASLD. Methods: Sixteen adults with MASLD (24–91 years) were assigned to an exercise group (n = 9) or a control group receiving lifestyle counselling (n = 7). The …

Disuse-Induced Muscle Atrophy And Muscle Weakness From Hospitalization To Spaceflight: Exercise Succeeds In Prevention And Treatment—A Meta-Analysis, Camila S. Padilha, Figueiredo, Rafael Deminice, S. Ribeiro, Robert U. Newton, Nicolas H. Hart, José Cesar Rosa-Neto, Marília Seelaender, Fábio Santos Lira

Research outputs 2022 to 2026

Background: Exercise has been proposed as both a preventive and therapeutic countermeasure; however, its effectiveness across different disuse conditions and timings of implementation remains uncertain. Methods: This systematic review and meta-analysis (PROSPERO: CRD42021256599) searched ClinicalTrials.gov, Cochrane Central, PubMed, SPORTDiscus, Web of Science, Scopus, CINAHL and SciELO from inception to May 2021, with an update in March 2025. Randomized and nonrandomized controlled trials examining exercise interventions during or after muscle disuse were included according to the PICOS framework. Random-effects meta-analysis evaluated effects on muscle strength, power and mass across hospitalization, bed rest and spaceflight conditions. Effect sizes (ES) are reported as …

April 2026, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

• Stress Awareness Month
• Stress Management Tips for Bulldogs
• Bulldog Resources

Redbird Scholar, Vol. 11, No. 2 (Spring 2026), Illinois State University, Office Of The Vice President For Research And Graduate Studies

Redbird Scholar

No abstract provided.

A Critical Narrative Review Appraisal Of The 2025–2030 Dietary Guidelines: Scientific Strengths, Conceptual Gaps, And Overlooked Dimensions Of Sustainability And Health Equity, Dimitrios Papandreou, Azza Alsuwaidi, Zainab Taha, Constantinos Giaginis, Georgios K. Vasios, Eleni P. Andreou

All Works

The 2025–2030 Dietary Guidelines introduce an important shift in public health nutrition, emphasizing minimally processed foods, higher protein intake, greater inclusion of full-fat dairy, and a food-based advice centered on “real food” consumption. While several of these recommendations align with accumulating evidence, particularly the discouragement of ultra-processed foods and added sugars, substantial concerns remain regarding their internal coherence, population-level applicability, risk of misinterpretation, as well as environmental footprint. This critical narrative review evaluates whether the scope, emphasis, and framing of the new guideline components are proportionate to the strength, consistency, and context of the underlying evidence. Using a novel framework …

Global Epidemiology Of Cephalopina Titillator Infestation In Camels: A Systematic Review And Meta-Analysis (1980–2025), Temesgen Mohammed, Aboma Zewude, Tsegaye Shamebo, Layaly Hamdan, Atef Oreiby, Hazim O. Khalifa, Gobena Ameni, Bojan Gajic

All Works

Background – Cephalopina titillator (C. titillator) is the causative agent of camel nasopharyngeal myiasis and is widespread in camel-rearing regions worldwide, causing impaired health, reduced productivity, and economic losses. However, despite the veterinary importance of C. titillator, global epidemiological evidence remains limited and fragmented, and no comprehensive synthesis of prevalence data across camel-rearing regions has previously been conducted. The objective of this review was to estimate the global pooled prevalence of C. titillator infestation in camels. In addition, subgroup analyses were made to assess the effect of camel species, geographic region, and study period on the pooled prevalence of C. …

Endocrine Roles Of Vitamin D In Female Reproduction: Mechanisms And Clinical Implications, Azza Alsuwaidi, Fatme Alanouti, Dimitrios Papandreou

All Works

Vitamin D a fat-soluble steroid hormone signals through Vitamin D Receptors (VDRs) located throughout the ovaries, uterus, placenta, hypothalamus, and pituitary gland, influencing immune regulation and female reproductive physiology. This review of studies from 2013-2025 found consistent associations between low vitamin D status and various disorders in women of childbearing age. In Premenstrual Syndrome (PMS), deficiency correlates with higher symptom severity, and evidence shows that supplementation significantly reduces total PMS scores, particularly improving mood-related domains. For uterine pathologies such as fibroids, endometriosis, and adenomyosis, low vitamin D status is linked to increased risk and severity. Repletion trials suggest antifibrotic and …

International Rice Outlook: International Rice Baseline Projections 2025-2035, A. Durand-Morat, W. Mulimbi

AAES Research Reports and Research Bulletins

• Over the next ten years, global rice consumption is projected to exceed global rice production, making existing stocks crucial for meeting the global rice market demand. • Global production is projected to grow mostly due to productivity gains and some area expansion, with India’s production performance becoming more relevant. • The global rice consumption is projected to climb, driven mainly by population growth. The average global per capita rice consumption is expected to drop slightly over the next decade, primarily due to slower per capita consumption growth in Asia and Africa. • The international prices of long-grain and medium-grain …

Advancing Fish Tissue Reference Material Development For Ag Nanoparticles Through A Perfusion Approach, Nathaniel J. Clark, Robert Clough, Adam Laycock, Rachel Smith, Richard D. Handy

School of Biological and Marine Sciences

There is a regulatory need for reliable methods to quantify nanoparticles in biological samples for the hazard assessment and bioaccumulation potential of engineered nanomaterials (ENMs). Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) is a promising technique, but its application is hindered by the lack of validated sample preparation procedures (e.g., solubilisation) and suitable biological reference materials. This study aimed to develop an in-house biological reference material for ENMs to support analytical method validation. Silver nanoparticles (Ag NPs) were introduced into rainbow trout via cardiac perfusion, with the gills and liver collected as target tissues. Tissues were homogenised using a …

Using Expert Elicitation And Systems Mapping To Support Social Innovation In The (Blue) Food System: The Case Of The Uk’S Plymouth Fish Finger, Clare Pettinger, Kelly Parsons, Yanaina Irazu Chavez-Ugalde, Louise Hunt, Carol Wagstaff

School of Health Professions

Background: The imperative for food system transformation is well known, yet to date there has been minimal emphasis on the blue food system [foods sourced from marine and freshwater environments]. Generally, a food systems approach should shift away from linear and move towards more systems thinking to embrace complexity. This paper focuses on a local social innovation project (Plymouth Fish Finger (PFF)) which has pioneered localising the blue food system. This study aimed to elicit how the (policy and practice) system around the PFF can be appraised to optimise social innovation practices for (blue) food system transformation. Methods: Expert elicitation …

Diagnostic Criteria And Management Of Melas And Stroke-Like Episodes: Consensus-Based Statements, Michelangelo Mancuso, Marcello Bellusci, Valerio Carelli, Irenaeus De Coo, Daria Diodato, Felix Distelmaier, Omar Hikmat, Michio Hirano, Rita Horvath, Amel Karaa, Thomas Klopstock, Mary Kay Koenig, Cornelia Kornblum, Chiara La Morgia, Piervito Lopriore, Mika Henrik Martikainen, Robert Mcfarland, Olimpia Musumeci, Robert D S Pitceathly, Guido Primiano, Shamima Rahman, Fernando Scaglia, Andrew Schaefer, Manuel Schiff, Luisa Semmler, Costanza Lamperti, Serenella Servidei

Faculty, Staff and Student Publications

Background and purpose: Mitochondrial Encephalomyopathy, Lactic acidosis and Stroke-like episodes (MELAS) is a rare multisystem mitochondrial disorder with clinical heterogeneity. Diagnostic criteria and management strategies for MELAS and mitochondrial stroke-like episodes (SLE) remain inconsistent. This work provides international consensus recommendations on the definition, diagnosis, and management of MELAS and SLE in pediatric and adult populations.

Methods: An international Delphi consensus process was conducted within the European Reference Network for Neuromuscular Diseases (ERN EURO-NMD), in collaboration with the US Mitochondrial Medicine Society, the ERN for Hereditary Metabolic Disorders (MetabERN), and patient representatives. Following a systematic literature review, 54 statements addressing diagnostic …

Weaning Drives Microbiome-Mediated Epigenetic Regulation To Shape Immune Memory In Mice, Li Yang, Robert C Peery, Shirui Zhou, Xiaomin Chen, Leah M Farmer, Fabiola Gutierrez, Stephanie Fowler, Lanjing Zhang, Julia M Salamat, Karen Riggins, Jiejun Shi, Lanlan Shen

Children’s Nutrition Research Center Staff Publications

During weaning, the transition to solid food diversifies the gut microbiome, triggering a programmed immune response critical for long-lasting mucosal immunity. Previous work showed that the gut microbiome mediates epigenetic development in intestinal stem cells (ISCs) during suckling, but what happens during weaning is unclear. Here, genome-wide profiling revealed that weaning-driven microbiome changes shape the DNA methylome and transcriptome of murine ISCs in an IFNγ-dependent manner. Specifically, we observe demethylation of enhancer elements essential for MHC class II genes, which results in a transcriptional memory that persists through differentiation into adulthood. IFNγ blockade, or low-dose penicillin to target Gram-positive bacteria, …

Tfeb Degradation Is Regulated By An Ikk/Β-Trcp2 Phosphorylation-Ubiquitination Cascade, Yan Xiong, Jaiprakash Sharma, Meggie N Young, Wen Xiong, Ali Jazayeri, Karl F Poncha, Ma Xenia G Ilagan, Qing Wang, Bei Gao, Hui Zheng, Nicolas L Young, Marco Sardiello

Center on Aging Staff Publications

Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and cellular clearance pathways. TFEB activity is tightly controlled by multiple post-translational mechanisms, but the exact molecular mechanism controlling its stability has remained elusive. Here, we identify the IκB kinase (IKK) complex as a key regulator of TFEB protein stability through a phosphorylation-ubiquitination cascade. A high-content kinase inhibitor screen reveals that IKK inhibition increases TFEB protein levels, and genetic ablation of IKK components increases TFEB stability, upregulates lysosomal genes, and enhances lysosomal biogenesis and degradative capacity. Mechanistically, we show that IKK phosphorylates TFEB on a cluster of serine residues …

Enhancing Feeding Skills: Development And Implementation Of A Pediatric Feeding Group Program In An Outpatient Setting, Alexia Spyrka

Capstone Projects

Children with autism spectrum disorder are five times more likely to present with feeding difficulties when compared to the general pediatric population (Baraskewich,et.al., 2021). Pediatric feeding difficulties can include picky eating, restrictive diets, limited independence with feeding skills, and limited food repertoire. Not only can this effect the child’s nutrition and growth but can affect family members as they are additionally focusing on their child's socialization, communication, and regulation. When addressing feeding difficulties, occupational therapy services are provided 1:1 with clients while educating and supporting family members to improve carry over into the home. However, there is a gap in …

Beyond Baby: How Occupational Therapy Supports Families In The Prenatal And Postpartum Period, Taylor Maysonet

Capstone Projects

This doctoral capstone project focuses on the role of occupational therapy in maternal and infant health, supporting families during the prenatal and postnatal period. While occupational therapy has a strong foundation in promoting health, independence, participation and roles and routines, there remains a gap in community awareness of available support for families during this life transition. Many caregivers report feeling underprepared, overwhelmed, and disconnected from resources that could support their physical, emotional, and occupational wellbeing.

The objective of this project was to identify gaps within the interdisciplinary team during the prenatal and postpartum period. From there, I was able to …

Draft 2025 Butte Priority Soils Operable Unit Residential Metals Abatement Program Construction Completion Report, Abby Peltomaa

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Implementing Hypertension Guidelines Into Clinical Practice, Misti Michele Mays

Electronic Theses and Dissertations

Hypertension is a complex chronic disease process, and it is essential to educate the patient on the disease process, as well as on all aspects of self-management. It is essential that providers choose an evidence-based guideline by which they will manage their hypertensive patients. In addition, providers must schedule regular follow-up appointments with their patients, along with a wide variety of other multifactorial components in regard to the management of patients diagnosed with hypertension. In addition, providers have a responsibility to stay informed on new approaches to blood pressure management by reviewing the professional literature on a regular basis. Much …

Propaganda Ai: An Analysis Of Semantic Divergence In Large Language Models, Nay Myat Min, Long H. Pham, Yige Li, Jun Sun

Research Collection School Of Computing and Information Systems

Large language models (LLMs) can exhibit concept-conditioned semantic divergence: common high-level cues (e.g., ideologies, public figures) elicit unusually uniform, stance-like responses that evade token-trigger audits. This behavior falls in a blind spot of current safety evaluations, yet carries major societal stakes, as such concept cues can steer content exposure at scale. We formalize this phenomenon and present RAVEN (Response Anomaly Vigilance), a black-box audit that flags cases where a model is simultaneously highly certain and atypical among peers by coupling semantic entropy over paraphrastic samples with cross-model disagreement. In a controlled LoRA fine-tuning study, we implant a concept-conditioned stance using …

Coping Under Constraint: How Consumer Vulnerability And Caregiver Status Shape Food Choice And Well-Being, Kerry-Ann V. Forbes, Prachi Gala

AMTP Proceedings 2026

Caregiving is a chronic and understudied form of consumer vulnerability that reshapes everyday decision-making, particularly in food contexts. This research conceptualizes caregiving as a sustained role-based vulnerability. It proposes a moderated-mediation model in which consumer vulnerability influences coping strategies that subsequently affect food choice and consumer well-being. Drawing on the Theory of Planned Behavior, Coping Theory, and Transformative Consumer Research, the study examines how caregiver status (familial, professional, or non-caregiver) serves as a boundary condition that shapes these relationships. A three-phase mixed-methods design is employed: qualitative interviews to refine constructs, a survey–experiment to test the moderated-mediation model, and an experimental …

Body Mass Index And Survival In Children Receiving Extracorporeal Membrane Oxygenation, Pilar Anton-Martin, Keith Baxelbaum, Shilpa Vellore, Erika O'Neil, Vinai Modem, Sameer Thadani

Faculty, Staff and Students Publications

Importance: Underweight and obesity represent opposite ends of the nutritional risk spectrum that negatively affect children's health worldwide. Both conditions have been associated with increased mortality in pediatric patients receiving extracorporeal membrane oxygenation (ECMO) support.

Objective: To investigate the association of underweight and obesity status with pediatric ECMO outcomes using body mass index (BMI) z scores.

Design, setting, and participants: This retrospective cohort analysis used data from the Extracorporeal Life Support Organization (ELSO) database from January 1, 2019, to December 31, 2023. Participants included all pediatric patients from international ECMO centers aged 29 days to 18 years who received ECMO …

Novel Variants Identified In Families With Snx27 -Related Neurodevelopmental Disorder, Aiding In Characterizing Its Genotypic And Phenotypic Spectrum, Tayyaba Shan, Abrar Hussain, Anushree Acharya, Mulazim Hussain, Yumei Li, Hafiz Muhammad Jafar Hussain, Kiran Afshan, Suzanne M Leal, Rui Chen, Asif Mir, Isabelle Schrauwen, Sabika Firasat

Faculty, Staff and Students Publications

Background:

Sorting Nexin 27 (SNX27), a key regulator of synaptic receptor trafficking and endosomal recycling, has been implicated in maintaining synaptic homeostasis and cognitive function. To date, variants in SNX27 have been reported in a small number of patients across three publications with severe neurodevelopmental phenotypes. However, the genetic and functional landscape of SNX27-related disorders remains poorly understood, and further evidence is needed to confirm its association with disease and to better delineate the associated phenotype.

Methods and Results:

Two unrelated Pakistani families with a total of five affected individuals segregating a neurodevelopmental disorder were investigated via exome …