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The Effects Of Hiit Versus Mict And Sedentary Controls On Blood Lipid Concentrations In Nondiabetic Overweight And Obese Young Adults: A Meta-Analysis., Christian P. Mccormick, Garrett Mamikunian, David B. Thorp Jun 2023

The Effects Of Hiit Versus Mict And Sedentary Controls On Blood Lipid Concentrations In Nondiabetic Overweight And Obese Young Adults: A Meta-Analysis., Christian P. Mccormick, Garrett Mamikunian, David B. Thorp

International Journal of Exercise Science

International Journal of Exercise Science 16(3): 791-813, 2023. With rates of obesity and dyslipidemia rising among young adults, this meta-analysis aimed to compare the effects of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) and sedentary controls (CON) on low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), and total cholesterol (TC) in nondiabetic overweight and obese young adults to determine if HIIT or MICT is more efficacious in improving dyslipidemia. Studies included in the analysis had to be randomized controlled trials or quasi-experimental studies, comparing the effects of HIIT versus MICT or CON on at least three variables of …


Evaluating The Effects Of Social Media On The Mental Health Of Dlsu-Is - Laguna Campus Grade 12 Students, Lara Althea Lunod Nunag, Mico Emison Cayago Bañadera, Kay Marianne Vicquierra Paguntalan, Julliana Marie Bernedo Rut Jun 2023

Evaluating The Effects Of Social Media On The Mental Health Of Dlsu-Is - Laguna Campus Grade 12 Students, Lara Althea Lunod Nunag, Mico Emison Cayago Bañadera, Kay Marianne Vicquierra Paguntalan, Julliana Marie Bernedo Rut

DLSU Senior High School Research Congress

Social media has become an integral part of the twenty-first century. Today, adolescents are one of the fastest-growing age groups for social media usage. Previous research has shown that mental health is one of the factors that is affected by social media usage. Mental health is an individual’s state of mind which includes their social, psychological, and emotional well-being. This study aims to determine whether there is a correlation between social media usage and the mental health of Senior High School (SHS) students at De La Salle University - Integrated School (DLSU-IS) Laguna campus. An online survey was administered containing …


Investigating The Physico-Chemical And Sensory Properties Of Coffee Fractions From The 4:6 Method, Nathaniel Angelo P. Arellano, Alyanna Claire L. Mejias, Janelle Nicolaine D. Sasi, Mariel M. Tamondong, Emmanuel V. Garcia Jun 2023

Investigating The Physico-Chemical And Sensory Properties Of Coffee Fractions From The 4:6 Method, Nathaniel Angelo P. Arellano, Alyanna Claire L. Mejias, Janelle Nicolaine D. Sasi, Mariel M. Tamondong, Emmanuel V. Garcia

DLSU Senior High School Research Congress

As coffee becomes the favored beverage by many, brewing processes have become popular. After winning the 2016 World Brewers Cup, Tetsu Kasuya’s 4:6 method has since been dominant. This study aimed to characterize the 4:6 method's fractions by investigating increments where changes in the brew become the most observable. The study determined that the pH level was at its greatest value in the first 40%, followed by an increasing trendline. Secondly, the TDS displayed the greatest value at around 40%, followed by a decreasing trendline. Given this, solids and acids dictating the coffee's acidity are dissolved earlier, while the 60% …


Evaluating The Effects Of Social Media On The Mental Health Of Dlsu-Is - Laguna Campus Grade 12 Students, Mico Emison C. Bañadera, Lara Althea L. Nunag, Kay Marianne V. Paguntalan, Julliana Marie B. Rut Jun 2023

Evaluating The Effects Of Social Media On The Mental Health Of Dlsu-Is - Laguna Campus Grade 12 Students, Mico Emison C. Bañadera, Lara Althea L. Nunag, Kay Marianne V. Paguntalan, Julliana Marie B. Rut

DLSU Senior High School Research Congress

Social media has become an integral part of the twenty-first century. Today, adolescents are one of the fastest-growing age groups for social media usage. Previous research has shown that mental health is one of the factors that is affected by the use of social media. Mental health is an individual’s state of mind which includes their social, psychological, and emotional well-being. The purpose of this study is to determine if there is no difference in the mental health among social media users of Senior High School (SHS) students at De La Salle University - Integrated School (DLSU-IS) Laguna campus between …


Determining The Occurrence And Effect Of Dysmenorrhea On The Productivity Of Ids 121 & 122 Female Dlsu-Is Students Manila, Linette Belle L.T. Ang, Yzabelle C. Bautista, Suzandra Kirstin Mikaela C. Chan, Jemina Gwyneth D. Pedres, Valerie A. Siy Jun 2023

Determining The Occurrence And Effect Of Dysmenorrhea On The Productivity Of Ids 121 & 122 Female Dlsu-Is Students Manila, Linette Belle L.T. Ang, Yzabelle C. Bautista, Suzandra Kirstin Mikaela C. Chan, Jemina Gwyneth D. Pedres, Valerie A. Siy

DLSU Senior High School Research Congress

Dysmenorrhea, the abdominal pain experienced during menstruation, has been prevalent in a vast percentage of women across the globe. Numerous studies stated that dysmenorrhea has taken a toll on the productivity of women, and further develops into a public health problem that negatively affects the economy. Inspired by this, the study aimed to determine the effect of the different intensity levels of dysmenorrhea and various applications of coping mechanisms in the productivity level of female IDs 121 and 122 students by means of distributing an online survey. The study gathered a sample of 78 respondents. Their responses were used for …


From Books To Binges: Academic Workload Stress, Emotional Eating Assessment, And Body Mass Index Among University Students In Metro Manila, Catrina Leyla Quizon La Madrid, Alexa Marie I. Aguirre Jun 2023

From Books To Binges: Academic Workload Stress, Emotional Eating Assessment, And Body Mass Index Among University Students In Metro Manila, Catrina Leyla Quizon La Madrid, Alexa Marie I. Aguirre

DLSU Senior High School Research Congress

Online learning has become the new standard in the educational system due to the COVID-19 pandemic. This change has resulted in various drawbacks, such as an increased workload and a feeling of isolation, which are stress factors among students. Furthermore, students are inclined to consume more through emotional eating due to increased stress from their academic workloads, leading to an increased Body Mass Index (BMI). This study describes the degree of emotional eating among university students during the pandemic. It investigates the influence of academic workload stress on emotional eating and, in turn, influences their body mass index. This study …


The Irregularity Of Menstruation Among Adolescents: A Sequential Mixed Methods Study With Regards To Stress And Sedentary Behavior, Amanda Louise L. Abante, Yhesa Camille O. Lorca, Zophiel Faye B. Lumabi, Kimberleigh D, Metrio Jun 2023

The Irregularity Of Menstruation Among Adolescents: A Sequential Mixed Methods Study With Regards To Stress And Sedentary Behavior, Amanda Louise L. Abante, Yhesa Camille O. Lorca, Zophiel Faye B. Lumabi, Kimberleigh D, Metrio

DLSU Senior High School Research Congress

There has been a lack of research on the irregular menstruation of female adolescents in the Philippines. However, few studies still exist on middle-aged women and young adults in urban areas. It was also stated that in the Philippines, menstrual disorders were the third most commonly reported gynecological morbidity (Campbell & Harlow, 2000). Thus, the study aims to research the mental stress and physical sedentary behavior concerning irregular menstruation of female adolescent Filipinos. Explanatory sequential mixed methods were used in the study, wherein the qualitative data expounded the quantitative. Non-probability sampling: Convenience sampling was used. The Google forms were disseminated …


(Anti)Poverty Measures Exposed, Francine J. Lipman Jun 2023

(Anti)Poverty Measures Exposed, Francine J. Lipman

Florida Tax Review

Few economic indicators have more salience and pervasive financial impact on everyday lives in the United States than poverty measures. Nevertheless, policymakers, researchers, advocates, and legislators generally do not understand the details of poverty measure mechanics. These detailed mechanics shape and reshape poverty measures and the too often uninformed responses and remedies. This Article will build a bridge from personal portraits of families living in poverty to the resource allocations that failed them by exposing the specific detailed mechanics underlying the Census Bureau’s official (OPM) and supplemental poverty measures (SPM). Too often, when we confront the problem of poverty, the …


Arnold-Chiari Malformation-I Borderline Personality Disorder, Aric Huber, Matthew Driben, Eduardo Espiridion Jun 2023

Arnold-Chiari Malformation-I Borderline Personality Disorder, Aric Huber, Matthew Driben, Eduardo Espiridion

Transformative Medicine

Introduction:
Arnold-Chiari Malformation I (AM-I) is a congenital anomaly that manifests with cerebellar dysfunction. There is a displacement of cerebellar tonsils into the foramen magnum. Several mood disorders, personality disorders, and intellectual disabilities are associated with AM-I. Borderline personality disorder (BPD) is characterized by symptoms of mood lability, impulsivity, extreme efforts of abandonment, splitting and dysfunctional relationships.

Case Description:
The patient is an early aged adult with a past medical history of AM-I, hypothyroidism, Wolff-Parkinson-White syndrome, and diabetes mellitus type II. The patient was admitted to the hospital after ingesting foreign bodies. He/she presented with mood lability, sad mood, anhedonia, …


Commentary On The Obesity Epidemic: A Family Medicine Perspective, Mediha B. Chaudhry, Katherine Goth Jun 2023

Commentary On The Obesity Epidemic: A Family Medicine Perspective, Mediha B. Chaudhry, Katherine Goth

Transformative Medicine

No abstract provided.


Dietary Inclusion Of Kulitis (Amaranthus Viridis) To Enhance Laying Hens’ Egg Quality, Kian Matthew S. Del Mundo, Mike Luigi G. Mario, Kirsten Khyla C. Zarate Jun 2023

Dietary Inclusion Of Kulitis (Amaranthus Viridis) To Enhance Laying Hens’ Egg Quality, Kian Matthew S. Del Mundo, Mike Luigi G. Mario, Kirsten Khyla C. Zarate

DLSU Senior High School Research Congress

Philippine poultry manufacturers choose selectively bred hens over native hens in commercial egg-laying operations due to the native hens’ lower egg production and lower egg weights. As such, it was decided to ascertain whether including 15% Kulitis (Amaranthus viridis) leaves in the hen diet can enhance egg quality, specifically overall egg weight, yolk color, and eggshell thickness. Two 26-week-old Darag hens weighing 1 kg were selected and fed standard feed (untreated hen) and Kulitis-infused feed pellets (treated hen) for 21 days. Water was given ad libitum. The first five eggs laid by each hen were collected and evaluated for overall …


Isolation, Characterization, And Identification Of The Most Common Bacterial Isolates From Second-Hand Clothes In Selected Ukay-Ukay Stores In Dasmarinas, Cavite, Ma. Zuzynne D. Ocampo, Lou Adrian D. Aquino Jr., Mariel Antonnia R. Aquino, Rinangem P. Buenavente, Nikka Alyzel M. Tropel Jun 2023

Isolation, Characterization, And Identification Of The Most Common Bacterial Isolates From Second-Hand Clothes In Selected Ukay-Ukay Stores In Dasmarinas, Cavite, Ma. Zuzynne D. Ocampo, Lou Adrian D. Aquino Jr., Mariel Antonnia R. Aquino, Rinangem P. Buenavente, Nikka Alyzel M. Tropel

DLSU Senior High School Research Congress

Throughout history, clothing's significance has evolved from a basic survival necessity to becoming an integral part of human social and cultural identity. Their sanitation significantly influences the health and condition of humans wearing these garments. For instance, clothes can serve as a reservoir for bacteria, fungi, and other germs that benefit or harm human health. Recent studies reveal the complex relationship between clothing and the microorganisms in our surroundings. This study aims to isolate, identify, and characterize the most common bacteria found in Second-Hand Clothing (SHCs) in Dasmarinas Cavite from three cotton shirts sampled from each of three random ukay-ukay …


Examination Of Domestic Tourists’ Awareness And Attitude Towards Halal Food According To Demographic Variable: The Gaziantep Example, Adem Ademoglu Jun 2023

Examination Of Domestic Tourists’ Awareness And Attitude Towards Halal Food According To Demographic Variable: The Gaziantep Example, Adem Ademoglu

Journal of Mediterranean Tourism Research

Religion and belief which are among the intangible cultural elements play an essential role in shaping consumer behavior. Among these behaviors, individuals’ increasing religious sensitivity within the context of eating and drinking in particular necessitates the food they consume to be in concordance with religious values. From this point of view, it is envisioned that individuals’ demographic characteristics will cause differences in food consumption demands in accordance with their religiousness values. The purpose of this study is to determine the role of demographic variables in the awareness towards halal food consumption and attitude towards halal food. Moreover, another purpose of …


June 27, 2023 Ereporter, University Of Alabama At Birmingham Jun 2023

June 27, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Targeting The Vulnerabilities Of Oncogene Activation, Christina Huang, Jack L. Arbiser Jun 2023

Targeting The Vulnerabilities Of Oncogene Activation, Christina Huang, Jack L. Arbiser

Student Papers, Posters & Projects

No abstract provided.


Wildlife Ecological Risk Assessment In The 21st Century: Promising Technologies To Assess Toxicological Effects, Barnett A. Rattner, Thomas G. Bean, Val R. Beasley, Philippe Berny, Karen M. Eisenreich, John E. Elliott, Margaret L. Eng, Phyllis C. Fuchsman, Mason D. King, Rafael Mateo, Carolyn B. Meyer, Jason M. O'Brien, Christopher J. Salice Jun 2023

Wildlife Ecological Risk Assessment In The 21st Century: Promising Technologies To Assess Toxicological Effects, Barnett A. Rattner, Thomas G. Bean, Val R. Beasley, Philippe Berny, Karen M. Eisenreich, John E. Elliott, Margaret L. Eng, Phyllis C. Fuchsman, Mason D. King, Rafael Mateo, Carolyn B. Meyer, Jason M. O'Brien, Christopher J. Salice

United States Geological Survey: Staff Publications

Despite advances in toxicity testing and the development of new approach methodologies (NAMs) for hazard assessment, the ecological risk assessment (ERA) framework for terrestrial wildlife (i.e., air‐breathing amphibians, reptiles, birds, and mammals) has remained unchanged for decades. While survival, growth, and reproductive endpoints derived from whole-animal toxicity tests are central to hazard assessment, nonstandard measures of biological effects at multiple levels of biological organization (e.g., molecular, cellular, tissue, organ, organism, population, community, ecosystem) have the potential to enhance the relevance of prospective and retrospective wildlife ERAs. Other factors (e.g., indirect effects of contaminants on food supplies and infectious disease processes) …


Primary Care Provider Density And Social Ecological Factors Related To County-Level Diabetes Prevalence In The United States, Robert Alan Kemsley Jun 2023

Primary Care Provider Density And Social Ecological Factors Related To County-Level Diabetes Prevalence In The United States, Robert Alan Kemsley

Theses and Dissertations

Diabetes is a critical public health concern with considerable financial and personal costs in the United States. Research has identified several interventions available to primary care providers to prevent diabetes. These interventions may prevent diabetes by influencing personal, community, and public health policy factors. These factors are key components of the social ecological model, which examines the influence of diverse social influences on health. Therefore, the purpose of this study was to determine the univariate relationship between PCP density and diabetes prevalence, as well as the multivariate relationship between PCP density and diabetes prevalence with physical inactivity prevalence, obesity prevalence, …


Randomized Intervention And Outpatient Follow-Up Lowers 30-D Readmissions For Patients With Hepatic Encephalopathy, Decompensated Cirrhosis, Antoinette Pusateri, Kevin Litzenberg, Claire Griffiths, Caitlin Hayes, Bipul Gnyawali, Michelle Manious, Sean G Kelly, Lanla F Conteh, Sajid Jalil, Haikady N Nagaraja, Khalid Mumtaz Jun 2023

Randomized Intervention And Outpatient Follow-Up Lowers 30-D Readmissions For Patients With Hepatic Encephalopathy, Decompensated Cirrhosis, Antoinette Pusateri, Kevin Litzenberg, Claire Griffiths, Caitlin Hayes, Bipul Gnyawali, Michelle Manious, Sean G Kelly, Lanla F Conteh, Sajid Jalil, Haikady N Nagaraja, Khalid Mumtaz

Faculty, Staff and Student Publications

BACKGROUND: We previously reported national 30-d readmission rates of 27% in patients with decompensated cirrhosis (DC).

AIM: To study prospective interventions to reduce early readmissions in DC at our tertiary center.

METHODS: Adults with DC admitted July 2019 to December 2020 were enrolled and randomized into the intervention (INT) or standard of care (SOC) arms. Weekly phone calls for a month were completed. In the INT arm, case managers ensured outpatient follow-up, paracentesis, and medication compliance. Thirty-day readmission rates and reasons were compared.

RESULTS: Calculated sample size was not achieved due to coronavirus disease 2019; 240 patients were randomized into …


High-Risk Fertility Behaviors: Impact On Child And Risks Of Maternal Mortality In Kenya, Mercy Chepkosgei Kiprop Jun 2023

High-Risk Fertility Behaviors: Impact On Child And Risks Of Maternal Mortality In Kenya, Mercy Chepkosgei Kiprop

Theses and Dissertations

Rapid population increase in Sub-Saharan Africa (SSA) over the last several decades and limited healthcare interventions have exacerbated child and maternal mortality. The maternal mortality ratio (deaths per 100,000 live births) in Sub-Saharan Africa accounts for at least 50 percent of maternal deaths globally. In 2020 alone, 5 million children under 5 years died in Kenya. Research also points out that, tragically, many of the mothers and children died of preventable or treatable conditions. Previous research has focused on biological or socioeconomic determinants of child mortality rather than their joint influences. In this study, we investigate the premise that all …


Spatial Single-Cell Sequencing Of Meiosis I Arrested Oocytes Indicates Acquisition Of Maternal Transcripts From The Soma, Kenneth A Trimmer, Peisen Zhao, Jacob Seemann, Shin-Yu Chen, Sudip Mondal, Adela Ben-Yakar, Swathi Arur Jun 2023

Spatial Single-Cell Sequencing Of Meiosis I Arrested Oocytes Indicates Acquisition Of Maternal Transcripts From The Soma, Kenneth A Trimmer, Peisen Zhao, Jacob Seemann, Shin-Yu Chen, Sudip Mondal, Adela Ben-Yakar, Swathi Arur

Faculty, Staff and Student Publications

Maternal RNAs are stored from minutes to decades in oocytes throughout meiosis I arrest in a transcriptionally quiescent state. Recent reports, however, propose a role for nascent transcription in arrested oocytes. Whether arrested oocytes launch nascent transcription in response to environmental or hormonal signals while maintaining the meiosis I arrest remains undetermined. We test this by integrating single-cell RNA sequencing, RNA velocity, and RNA fluorescence in situ hybridization on C. elegans meiosis I arrested oocytes. We identify transcripts that increase as the arrested meiosis I oocyte ages, but rule out extracellular signaling through ERK MAPK and nascent transcription as a …


Managing E-Mindful Tourism Experiences: A Co-Creation Approach, Uglješa Stankov Jun 2023

Managing E-Mindful Tourism Experiences: A Co-Creation Approach, Uglješa Stankov

ITSA 2022 Gran Canaria - 9th Biennial Conference: Corporate Entrepreneurship and Global Tourism Strategies After Covid 19

No abstract provided.


American Indian Residential Boarding Schools: Historical Trauma And The Role Of Government, Churches, And Tribes In Healing Indigenous Communities, Briana Slaubaugh Jun 2023

American Indian Residential Boarding Schools: Historical Trauma And The Role Of Government, Churches, And Tribes In Healing Indigenous Communities, Briana Slaubaugh

Liberty Theological Review

Throughout the 19th and 20th centuries, Native Americans and Indigenous tribes in North America faced systematic destruction of their cultures, genocide, and extreme abuse. With wars against Native Americans, forced relocation from their historic lands, and mandatory residential boarding schools where Indigenous children were forcibly separated from their parents, the social fabric of Native American communities was destroyed. These travesties were government sanctioned and enacted by churches. The American Indian Residential Schools serve as the most recent and egregious factories of abuse. The policies and actions enforced against Native Americans left a generation plagued by abuse leaving a …


Human Ecology, 1989, V18 N2, Advocate Aurora Health Jun 2023

Human Ecology, 1989, V18 N2, Advocate Aurora Health

Historical Documents - Combined

Lutheran General Hospital, Park Ridge, IL: Biannual magazine produced for the Friends of the Affiliated Corporations of Lutheran General Health Care System. This issue has features on addiction in the medical profession, a mission trip in Honduras, a journal about a 3+ month infant in the NICU, memory and dementia, workplace accidents, and an update from the annual fundraising gala.


Human Ecology, 1990, V19 N1, Advocate Aurora Health Jun 2023

Human Ecology, 1990, V19 N1, Advocate Aurora Health

Historical Documents - Combined

Lutheran General Hospital, Park Ridge, IL: Biannual magazine produced for the Friends of the Affiliated Corporations of Lutheran General Health Care System. This issue has features on earlier discharge trends, chronic pain, grief, the death of the first president of Lutheran General Hospital Naurice M. Nesset, navigating Medicare, living with a heart transplant, and alcohol abuse in women. It also contains the annual list of donors.


Human Ecology, 1991, V20 N1, Advocate Aurora Health Jun 2023

Human Ecology, 1991, V20 N1, Advocate Aurora Health

Historical Documents - Combined

Lutheran General Hospital, Park Ridge, IL: Biannual magazine produced for the Friends of the Affiliated Corporations of Lutheran General Health Care System. This issue has features on adult day health services, addiction, Fragile X Syndrome, euthanasia, weight loss, and a doctor with hearing loss. It also features the annual donor list.


Human Ecology, 1991, V20 N2, Advocate Aurora Health Jun 2023

Human Ecology, 1991, V20 N2, Advocate Aurora Health

Historical Documents - Combined

Lutheran General Hospital, Park Ridge, IL: Biannual magazine produced for the Friends of the Affiliated Corporations of Lutheran General Health Care System. This issue has features on a day in the life of a nurse, charity and community activities by the hospital, heart surgery, and advance directives. It also features an update from the annual fundraising gala.


Biological Case Against Downlisting The Whooping Crane And For Improving Implementation Under The Endangered Species Act, Andrew J. Caven, Hillary L. Thompson, David M. Baasch, Barry K. Hartup, Amanda M. Hegg, Stephanie M. Schmidt, Irvin Louque, Craig R. Allen, Carter G. Crouch, Craig A. Davis, Joel G. Jorgensen, Jane E. Austin, Bethany L. Ostrom, Richard D. Beilfuss, George W. Archibald, Anne E. Lacy Jun 2023

Biological Case Against Downlisting The Whooping Crane And For Improving Implementation Under The Endangered Species Act, Andrew J. Caven, Hillary L. Thompson, David M. Baasch, Barry K. Hartup, Amanda M. Hegg, Stephanie M. Schmidt, Irvin Louque, Craig R. Allen, Carter G. Crouch, Craig A. Davis, Joel G. Jorgensen, Jane E. Austin, Bethany L. Ostrom, Richard D. Beilfuss, George W. Archibald, Anne E. Lacy

School of Natural Resources: Faculty Publications

The Whooping Crane (Grus americana; WHCR) is a large, long-lived bird endemic to North America. The remnant population migrates between Aransas National Wildlife Refuge, USA, and Wood Buffalo National Park, Canada (AWBP), and has recovered from a nadir of 15-16 birds in 1941 to ~540 birds in 2022. Two ongoing reintroduction efforts in Louisiana and the Eastern Flyway together total ~150 birds. Evidence indicates the U.S. Fish and Wildlife Service (USFWS) is strongly considering downlisting the species from an endangered to a threatened status under the Endangered Species Act (ESA). We examined the current status of the WHCR through the …


Sociodemographic And Health-Related Risks For Loneliness And Outcome Differences By Loneliness Status In A Sample Of Older U.S. Adults, Laurie A. Theeke Jun 2023

Sociodemographic And Health-Related Risks For Loneliness And Outcome Differences By Loneliness Status In A Sample Of Older U.S. Adults, Laurie A. Theeke

Dissertations

Loneliness is a prevalent problem for older adults and has been shown to be associated with negative physical, psychological, and social variables. There has been limited research focusing on the relationship of loneliness to health. There is a gap in the literature when it comes to understanding how the problem of loneliness relates to the health of older adults in the United States.

The purpose of this study was to address this gap in the literature through the testing of two models, the first model represented the postulated risks for loneliness and the second model represented the postulated outcomes for …


Energetic Costs Of Testosterone In Two Subsistence Populations, Benjamin C. Trumble, Herman Pontzer, Jonathan Stieglitz, Daniel K. Cummings, Brian Wood, Melissa Emery Thompson, David Raichlen, Bret Beheim, Gandhi Yetish, Hillard Kaplan, Michael Gurven Jun 2023

Energetic Costs Of Testosterone In Two Subsistence Populations, Benjamin C. Trumble, Herman Pontzer, Jonathan Stieglitz, Daniel K. Cummings, Brian Wood, Melissa Emery Thompson, David Raichlen, Bret Beheim, Gandhi Yetish, Hillard Kaplan, Michael Gurven

ESI Publications

Objective

Testosterone plays a role in mediating energetic trade-offs between growth, maintenance, and reproduction. Investments in a high testosterone phenotype trade-off against other functions, particularly survival-enhancing immune function and cellular repair; thus only individuals in good condition can maintain both a high testosterone phenotype and somatic maintenance. While these effects are observed in experimental manipulations, they are difficult to demonstrate in free-living animals, particularly in humans. We hypothesize that individuals with higher testosterone will have higher energetic expenditures than those with lower testosterone.

Methods

Total energetic expenditure (TEE) was quantified using doubly labeled water in n = 40 Tsimane forager-horticulturalists …


Detrimental Effects Of Pcsk9 Loss-Of-Function In The Pediatric Host Response To Sepsis Are Mediated Through Independent Influence On Angiopoietin-1., Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder, Patrick Lahni, Scarlett Ripberger, Adesuwa Ekunwe, Kyle R. Campbell, Keith R. Walley, Stephen W. Standage Jun 2023

Detrimental Effects Of Pcsk9 Loss-Of-Function In The Pediatric Host Response To Sepsis Are Mediated Through Independent Influence On Angiopoietin-1., Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder, Patrick Lahni, Scarlett Ripberger, Adesuwa Ekunwe, Kyle R. Campbell, Keith R. Walley, Stephen W. Standage

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Sepsis is associated with significant mortality. Yet, there are no efficacious therapies beyond antibiotics. PCSK9 loss-of-function (LOF) and inhibition, through enhanced low-density lipoprotein receptor (LDLR) mediated endotoxin clearance, holds promise as a potential therapeutic approach among adults. In contrast, we have previously demonstrated higher mortality in the juvenile host. Given the potential pleiotropic effects of PCSK9 on the endothelium, beyond canonical effects on serum lipoproteins, both of which may influence sepsis outcomes, we sought to test the influence of PCSK9 LOF genotype on endothelial dysfunction.

METHODS: Secondary analyses of a prospective observational cohort of pediatric septic shock. Genetic variants …