Digital Commons Network^™

Transformative Approach To Developing A Sustainable Interprofessional Education Program, Tilicia Mayo-Gamble, Jane Nester, Paula Tillman, Sandhya Lohani, Padmini Shankar, Pamela Mahan

Journal of the Georgia Public Health Association

Background: The ability to offer and sustain interprofessional collaboration and education (IPE) in an academic setting could potentially serve as a training model for other academic institutions to implement programs that will increase the number of practice-ready, culturally competent healthcare professionals. We designed, implemented, and evaluated an Area Health Education Center (AHEC) Scholars Program to train culturally competent interdisciplinary students to provide quality, patient-centered healthcare in rural and underserved communities post-graduation.

Methods: Two cohorts of students (Cohort 1, n = 15, Cohort 2, n = 14) were recruited into a two-year longitudinal program with 80 hours of didactic learning and …

Evaluating Vaccine Management Strategies For Edwardsiella Ictaluri Infections In Zebrafish (Danio Rerio), Brandy Malbrough

LSU Master's Theses

Aquaculture is a globally important industry that faces significant challenges due to infectious diseases, which can result in substantial financial losses. In 2011, a new strain of Edwardsiella ictaluri emerged as a major pathogen affecting zebrafish in the ornamental fish industry, leading to high mortality rates and posing a severe threat to the sector. Vaccines provide potential benefits for disease prevention in aquaculture, particularly live-attenuated vaccines (LAVs), which induce strong host immune responses. Bacterial attenuation for vaccine development has evolved from serial passage to more targeted genetic modification techniques. However, regulatory constraints limit the availability of licensed LAVs for aquaculture. …

A Nexus Of Supportive Infrastructure To Foster Student Learning, Engagement, & Flourishing During The Covid-19 Pandemic, Angel Lin, Maria Garcia, Lucas Negritto

Silicon Valley Sociological Review

In 2020, educators and students were faced with a global pandemic that created unprecedented challenges to classrooms across the nation. For many students, the shift to online learning in a necessary effort to maintain educational continuity lasted for an entire academic year. Students attended online synchronous and asynchronous class sessions, interacted with their peers in exclusively online settings, and were isolated to the social and economic constraints of their own households. This study examines the dramatic impact that these virtual learning experiences had on middle school students’ learning, engagement, and development during the COVID-19 pandemic. By interviewing middle school students, …

Silicon Valley Sociological Review Vol. 21 2023

Silicon Valley Sociological Review

No abstract provided.

Stethoscope, 1979 May, Advocate Aurora Health

Historical Documents - Combined

Mount Sinai Medical Center, Milwaukee, WI: May 1979 edition of the Stethoscope, a Mount Sinai Medical Center publication. Includes articles on National Hospital Week, the new Neonatal Special Care nursery, the first annual Scientific Day, images from the first annual House Staff Ball, and various personnel announcements.

Tenure And Promotion Announcement, 2023, University Of Mississippi. Provost

Tenure and Promotion Announcements

No abstract provided.

Proteoglycan 4 (Prg4)/Lubricin And The Extracellular Matrix In Gout, Khaled A. Elsaid, Gregory D. Jay, Ru Liu-Bryan, Robert Terkeltaub

Pharmacy Faculty Articles and Research

Proteoglycan 4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes, released into synovial fluid, and adsorbed on cartilage and synovial surfaces. PRG4′s roles include cartilage boundary lubrication, synovial homeostasis, immunomodulation, and suppression of inflammation. Gouty arthritis is mediated by monosodium urate (MSU) crystal phagocytosis by synovial macrophages, with NLRP3 inflammasome activation and IL-1β release. The phagocytic receptor CD44 mediates MSU crystal uptake by macrophages. By binding CD44, PRG4 limits MSU crystal uptake and downstream inflammation. PRG4/CD44 signaling is transduced by protein phosphatase 2A, which inhibits NF-κB, decreases xanthine oxidoreductase (XOR), urate production, and ROS-mediated IL-1β …

High Glucose-Upregulated Pd-L1 Expression Through Ras Signaling-Driven Downregulation Of Ptrh1 Leads To Suppression Of T Cell Cytotoxic Function In Tumor Environment, Chenggang Gao, Jiaoshun Chen, Jianwei Bai, Haoxiang Zhang, Yanyi Tao, Shihong Wu, Hehe Li, Heshui Wu, Qiang Shen, Tao Yin

School of Graduate Studies Faculty Publications

Background: Nearly 80% of patients with pancreatic cancer suffer from glucose intolerance or diabetes. Pancreatic cancer complicated by diabetes has a more immunosuppressive tumor microenvironment (TME) and is associated with a worse prognosis. The relationship between glucose metabolism and programmed cell death-Ligand 1 (PD-L1) is close and complex. It is important to explore the regulation of high glucose on PD-L1 expression in pancreatic cancer and its effect on infiltrating immune effectors in the tumor microenvironment. Methods: Diabetic murine models (C57BL/6) were used to reveal different immune landscape in euglycemic and hyperglycemic pancreatic tumor microenvironment. Bioinformatics, WB, iRIP [Improved RNA Binding …

Determinants Of Spiritual Well-Being In Adults Newly Diagnosed With Heart Failure: Primary Palliative Care Applied, Valerie Joy Smith

Dissertations

Guided by Roy's Adaptation Model (Roy, 2009) and using a descriptive, correlational, comparative design, sociodemographic characteristics (age, gender, race, marital status, income), coping, primary palliative care (PPC, spiritual needs, social support, decision-making [DM] engagement, psychological support, PPC information and education provision, goals of care discussion, and care coordination across settings and times), spiritual well-being (SWB), and advance directive (AD) completion in response to living with a HF diagnosis within the previous 12 months were described and the potential relationships and differences between the variables explored.

When A Calorie Is Not Just A Calorie: Diet Quality And Timing As Mediators Of Metabolism And Healthy Aging, Maria M Mihaylova, Amandine Chaix, Mirela Delibegovic, Jon J Ramsey, Joseph Bass, Girish Melkani, Rajat Singh, Zheng Chen, William W Ja, Michele Shirasu-Hiza, Mary N Latimer, Julie A Mattison, Anna E Thalacker-Mercer, Vishwa Deep Dixit, Satchidananda Panda, Dudley W Lamming

Faculty, Staff and Student Publications

An epidemic of obesity has affected large portions of the world, increasing the risk of developing many different age-associated diseases, including cancer, cardiovascular disease, and diabetes. In contrast with the prevailing notion that "a calorie is just a calorie," there are clear differences, within and between individuals, in the metabolic response to different macronutrient sources. Recent findings challenge this oversimplification; calories from different macronutrient sources or consumed at different times of day have metabolic effects beyond their value as fuel. Here, we summarize discussions conducted at a recent NIH workshop that brought together experts in calorie restriction, macronutrient composition, and …

Phytoplankton Responses To Dust Addition In The Femn Co-Limited Eastern Pacific Sub-Antarctic Differ By Source Region, Neil J. Wyatt, Antony Birchill, Simon Ussher, Angela Milne, Heather A. Bouman, Elizabeth Shoenfelt Troein, Katsiaryna Pabortsava, Alan Wright, Oliver Flanagan, Thomas S. Bibby, Adrian Martin, Cm Moore

School of Geography, Earth and Environmental Sciences

The seasonal availability of light and micronutrients strongly regulates productivity in the Southern Ocean, restricting biological utilization of macronutrients and CO2 drawdown. Mineral dust flux is a key conduit for micronutrients to the Southern Ocean and a critical mediator of multimillennial-scale atmospheric CO2 oscillations. While the role of dust-borne iron (Fe) in Southern Ocean biogeochemistry has been examined in detail, manganese (Mn) availability is also emerging as a potential driver of past, present, and future Southern Ocean biogeochemistry. Here, we present results from fifteen bioassay experiments along a north–south transect in the undersampled eastern Pacific sub-Antarctic zone. In addition to …

Morphological And Molecular Characterization Of The Olfactory System In The Formosan Subterranean Termite, Paula Castillo

LSU Doctoral Dissertations

The Formosan subterranean termite, Coptotermes formosanus, is a eusocial insect species. Its members live in colonies consisting of reproductive (queen and king) and non-reproductive individuals (workers and soldiers). Olfaction is an essential sense for the social life of many insects. However, in termites, little is known about how olfactory cues are perceived in the peripheral sensory system (antennae) and processed in the central nervous system (brain) to elicit different behavioral responses across castes. In this study, we investigated the olfactory system in all castes (soldiers, workers, and reproductive alates), from the antennal and brain morphology to the antennal gene …

The Role Of Television Sports Programs In Shaping Awareness Of Physical Health Among Jordanian University Students, Amer K. Ahmad, Othman Tahat, Amjad O. Safori, Ashraf Al-Zpubi, Huda K. Ahmad, Azzam Ananza

Information Sciences Letters

The studys objectives were to ascertain the volume of television sports programming watched by college students in Jordanian universities as well as how these programs influenced their understanding of physical fitness. This was accomplished by using a survey method on 400 students from Yarmouk University and Zarqa University, who made up an equally stratified sample. The findings showed that men watch more television sports programming than women. Additionally, people who regularly exercise tend to watch these programs more than those who do not exercise at all. The results also showed that Yarmouk University students, as opposed to students at Al-Zarqa …

Impact Of Social Media Ads On Unhealthy Food Concepts And Adolescent Health In Jazan Region, Najwan M. Harazi, Dunia M. Farghly

Information Sciences Letters

In this paper, we examine the impact of social media advertisements on the eating habits of teenagers and children in the Jazan region, focusing on the promotion of unhealthy food. The researchers used the historical method and a survey method with a sample of 209 adolescents and youths. The study recommends incentivizing traditional food stores, developing a national strategy to minimize fast-food industry, issuing laws for planning, and organizing fast-food stores, and monitoring social media advertisements. Additionally, promoting traditional food stores, creating a national app to educate teenagers and children, and establishing a database for fast-food stores and their products …

Impact Of Rehabilitative Ultrasonography Imaging On Core Muscle Function In Patients With Visceral Adiposity: Randomized Controlled Trail, Omar M. Mabrouk, Amal H. Mohamed Ibrahim, Mayada Ashraf, Mohamed A. Shwiel

International Journal of Thin Film Science and Technology

Background: Overweight is an excessive fat accumulation that may impair health. Visceral adiposity is one of the common causes of decreased endurance and strength of core stabilizing muscles, lumbar spine dysfunction and respiratory impairment. Consequently, this study aimed to determine the impact of rehabilitative ultrasonography imaging (RUSI) guided core muscle exercise, cavitation lipolysis and their combination on visceral fat thickness, waist circumference (WC), transverse abdominis (TrA) activation ratio, and diaphragmatic excursion in patients with visceral adiposity. Methods: forty-five patients diagnosed as overweight with localized abdominal visceral fat deposits, recruited from clinical nutrition unit, Elminya University Hospital. Patients age ranged from …

Effect Of Endurance Training On Homocysteine Level In Elderly With Megaloblastic Anemia, Amir Abdel Moaty Serag, Nesreen Ghreeb Al Nahas, Gehan Mohamed Shaera, Azza Abdel Aziz Abdel Hady

International Journal of Thin Film Science and Technology

Background: Vitamin B12 deficiency causes megaloblastic anemia and it’s a major contributor to hyper-homo- cysteinemia which have been linked to the risk of vascular disease, stroke, and dementia and are relatively common in elderly. Aim of Study: To investigate effect of endurance training program on homocysteine level in elderly patients with megaloblastic anemia. Methods: Sixty elderly patients suffered from megaloblastic anemia, participated in this study were selected randomly from out-patient clinic of internal medicine in Sers Ellyan hospital with age mean ± SD values in groups (A) and (B) were 68.23±2.74 and 67.83±2.19 years, respectively. The study design was pre-post …

Effect Of Pilates Exercises On Cortisol Hormone And Blood Pressure Among Hypertensive Women, H. F. Barghout, A. A. Abdel Hady, A. A. Shaheen, N. G. El Nahas

International Journal of Thin Film Science and Technology

Background: Hypertension is a major risk factor for cardiovascular diseases such as stroke and coronary artery disease as well as causes mortality. The Pilates method is a conditioning program in hypertensive patients of the body and mind that is gaining in popularity and acceptance worldwide. Aim of Study: To determine the response of cortisol hormone level and blood pressure after Pilates exercise in hypertensive post-menopausal women. Methods: Sixty women participated in this study was selected from Belbies Central employees and outpatient clinic with age mean ± SD values in groups (A) and (B) were 52.83 ± 3.89 and 53.37 ± …

Negative Impact Of Chronic Pandemic-Specific Financial Stress On Food Security Among College Students, Julia N. Soulakova,, Lisa J. Crockett, Mary Schmidt-Owens, Eric W. Schrimshaw

Department of Psychology: Faculty Publications

Since the pandemic started, food insecurity has become a more serious issue for U.S. college students. The study goals were to evaluate whether pandemic-specific stress contributes to current food insecurity (as of February–March of 2022) and to determine which student characteristics are associated with food insecurity. We used the 2022 Spring American College Health Association— National College Health Assessment data (n = 620) collected at a public university. We estimated two multiple logistic regression models. The odds of having very low food security (OR = 8.65, 95% CI = 4.84:15.43) and low food security (OR = 2.87, 95% CI …

Potential Biomarker Of Brain Response To Opioid Antagonism In Adolescents With Eating Disorders: A Pilot Study., Stephani L. Stancil, Hung-Wen Yeh, Morgan G. Brucks, Amanda S. Bruce, Michaela Voss, Susan Abdel-Rahman, William M. Brooks, Laura E. Martin

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Eating Disorders (ED) affect up to 5% of youth and are associated with reward system alterations and compulsive behaviors. Naltrexone, an opioid antagonist, is used to treat ED behaviors such as binge eating and/or purging. The presumed mechanism of action is blockade of reward activation; however, not all patients respond, and the optimal dose is unknown. Developing a tool to detect objective drug response in the brain will facilitate drug development and therapeutic optimization. This pilot study evaluated neuroimaging as a pharmacodynamic biomarker of opioid antagonism in adolescents with ED.

METHODS: Youth aged 13-21 with binge/purge ED completed functional …

Passive And Social Screen Time In Children With Autism And In Association With Obesity, Aviva Must, Misha Eliasziw, Heidi Stanish, Carol Curtin, Linda G. Bandini, April Bowling

Health Sciences Faculty Publications

Background: Screen time has been identified as a risk factor for childhood obesity, but the media landscape has evolved rapidly. Children with autism tend to be heavy users of screens and have an elevated prevalence of obesity. We know little about screen use patterns among children with autism vs. typically developing (TD) peers and in association with obesity.

Methods: Baseline data from 10,842 participants in the Adolescent Brain Cognition Development Study was used to characterize time spent with child-reported passive screen use (television/movies/watching videos), playing video games, and using social media. Duration of screen time by autism status and gender …

Sesame Eliciting And Safe Doses In A Large Sesame Allergic Population, Liat Nachshon, Joost Westerhout, W. Marty Blom, Benjamin Remington, Michael B. Levy, Michael R. Goldberg, Naama Epstein-Rigbi, Yitzhak Katz, Arnon Elizur

Department of Nutrition and Health Sciences: Faculty Publications

Background: Sesame is a significant food allergen causing severe and even fatal reactions. Given its increasing prevalence in western diet, sesame is listed as an allergenic food requiring labeling in the United States and EU. However, data on the population reaction doses to sesame are limited.

Methods: All sesame oral food challenges (OFCs), performed either for diagnosis or for threshold identification before the beginning of sesame oral immunotherapy (OIT) between November 2011 and July 2021 in Shamir medical center were analyzed for reaction threshold distribution. Safe-dose challenges with 90–120 min intervals were also analyzed.

Results: Two hundred …

Accumulation Of Chronic Disease Among Survivors Of Childhood Cancer Predicts Early Mortality, Adam J Esbenshade, Lu Lu, Debra L Friedman, Kevin C Oeffinger, Gregory T Armstrong, Kevin R Krull, Joseph P Neglia, Wendy M Leisenring, Rebecca Howell, Robyn Partin, Amy Sketch, Leslie L Robison, Kirsten K Ness

Faculty, Staff and Student Publications

Purpose: Cancer survivors develop cancer and treatment-related morbidities at younger than normal ages and are at risk for early mortality, suggestive of an aging phenotype. The Cumulative Illness Rating Scale for Geriatrics (CIRS-G) is specifically designed to describe the accumulation of comorbidities over time with estimates of severity such as total score (TS) which is a sum of possible conditions weighted by severity. These severity scores can then be used to predict future mortality.

Methods: CIRS-G scores were calculated in cancer survivors and their siblings from Childhood Cancer Survivor Study cohort members from two time points 19 years apart and …

Revisional Bariatric Surgery For Weight Recurrence Or Surgical Nonresponse, Erin Briggs, Sunjay Kumar, Francesco Palazzo, Talar Tatarian

Department of Surgery Faculty Papers

No abstract provided.

Neonatal Diet Type And Associations With Adverse Feeding Outcomes And Gut Microbiome Composition In Neonates With Critical Congenital Heart Defects, Jessica A. Davis

Sigma Foundation for Nursing Research Grant Reports

The purpose of the proposed longitudinal observational study was to: 1) investigate the relationship between variations in neonatal diet type and incidence of feeding intolerance, necrotizing enterocolitis, and malnutrition in a retrospective cohort; and 2) describe study feasibility and explore associations between neonatal diet and gut microbiome composition in a prospective cohort.

The Effects Of Ketones On Brain Metabolism And Cognition, Erin Reiko Saito

Theses and Dissertations

The brain is one of the most energetically demanding organs within the human body and is cognitively susceptible to energetic deficits such that the rise in obesity, insulin resistance, and Alzheimer’s disease in recent decades pose a substantial threat to cognitive longevity. The therapeutic efficacy of ketones are well-established in epilepsy and are currently being applied to other disease states. Alzheimer’s disease is characterized by impairments in brain glucose uptake and metabolism in regions relevant to learning, memory, and cognition that progress with the disease. While brain glucose uptake is impaired, ketone uptake is unaltered, potentially enabling ketones to fuel …

Glucose-Enhanced Oxidative Stress Resistance—A Protective Anticipatory Response That Enhances The Fitness Of Candida Albicans During Systemic Infection, De Larcombe, Im Bohovych, A Pradhan, Q Ma, E Hickey, I Leaves, G Cameron, Gm Avelar, Lj De Assis, Ds Childers, Jm Bain, K Lagree, Ap Mitchell, Mg Netea, Lp Erwig, Nar Gow, Ajp Brown

Peninsula Medical School

Most microbes have developed responses that protect them against stresses relevant to their niches. Some that inhabit reasonably predictable environments have evolved anticipatory responses that protect against impending stresses that are likely to be encountered in their niches–termed “adaptive prediction”. Unlike yeasts such as Saccharomyces cerevisiae, Kluyveromyces lactis and Yarrowia lipolytica and other pathogenic Candida species we examined, the major fungal pathogen of humans, Candida albicans, activates an oxidative stress response following exposure to physiological glucose levels before an oxidative stress is even encountered. Why? Using competition assays with isogenic barcoded strains, we show that “glucose-enhanced oxidative stress resistance” phenotype …

Social Rights And Transformative Private Law, Edward BéChard-Torres

Osgoode Hall Law Journal

Although constitutional social rights continue to attract much scholarly attention, their role in shaping private law is often overlooked. This neglect has led some scholars to underestimate social rights’ transformative potential. This article considers social rights’ influence over contract and property law in India, Colombia, and South Africa—three leading jurisdictions of the Global South. It argues that social rights can promote redistributive outcomes and inspire important shifts in private law’s values and modes of reasoning. However, it cautions that the depth of this transformation will depend on how judges choose to cross the public– private divide. One tradition rejects any …

Differentials And Predictors Of Food Insecurity Among Federally Qualified Health Center Target Populations In Philadelphia: A Cross-Sectional Study, Galicano Kai Inguito, Brandon Joa, James Gardner, Eric N Fung, Laura Layer, Karen Fritz

Department of Medicine Faculty Papers

BACKGROUND: Over the past decade, the prevalence of food insecurity declined in the United States but curiously climbed in Philadelphia, Pennsylvania, a sizable metropolitan area where many households experience food insecurity and are dependent on programs like SNAP. Therefore, we aimed to determine the burden of food insecurity among populations near Philadelphia Federally Qualified Health Center (FQHC) clinic sites.

METHODS: This cross-sectional study was conducted in North Philadelphia, a populous and impoverished section of Philadelphia with many zip codes reporting 30-45% or more of the population below the federal poverty line. Students and clinicians affiliated with a local FQHC conducted …

Hydrolysis Of Chlorogenic Acid In Sunflower Flour Increases Consumer Acceptability Of Sunflower Flour Cookies By Improving Cookie Color, Christine Lo Verde, Criselda Toto Pacioles, Natalie Paterson, Jamie Chin, Cedric P. Owens, Lilian W. Senger

Food Science Faculty Articles and Research

Sunflower meal, a byproduct of sunflower oil pressing, is not commonly used in alkaline baking applications. This is because chlorogenic acid, the main phenolic antioxidant in sunflower seeds, reacts with protein, giving the baked product a green discoloration. Our group previously demonstrated that a chlorogenic acid esterase from Lactobacillus helveticus hydrolyzes chlorogenic acid in sunflower dough cookie formulations, resulting in cookies that were brown instead of green. This study presents a sensory analysis to determine the acceptability of enzymatically upcycled sunflower meal as an alternative protein source for those allergic to meals from legumes or tree nuts. We hypothesized that …

Overactive Bladder Syndrome Symptoms In Youth With Abdominal Pain-Associated Disorders Of Gut-Brain Interaction., Hunter J. Friesen, Pierce Thompson, Jennifer Verrill Schurman, Jennifer Colombo, Craig A. Friesen

Manuscripts, Articles, Book Chapters and Other Papers

The purpose of the current study was to assess the frequency of overactive bladder syndrome (OBS) symptoms and their relationship to gastrointestinal symptoms in youth with abdominal pain-associated disorders of gut-brain interaction (AP-DGBI). This is a retrospective study of 226 youth diagnosed with an AP-DGBI. As part of standard care, all patients completed a symptom questionnaire regarding gastrointestinal and non-gastrointestinal symptoms including increased urinary frequency, nighttime urination, and urinary urgency. Overall, 54% of patients reported at least one OBS symptom. Increased frequency of urination was reported by 19%, urinary urgency by 34%, and nighttime urination by 36%. Increased frequency of …