Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (47717)
- Life Sciences (44806)
- Social and Behavioral Sciences (30158)
- Education (18917)
- Public Health (12195)
-
- Physical Sciences and Mathematics (10855)
- Law (10099)
- Medical Specialties (9966)
- Arts and Humanities (9920)
- Plant Sciences (8432)
- Agriculture (7708)
- Animal Sciences (7532)
- Higher Education (6738)
- Nutrition (6419)
- Medical Sciences (6258)
- Nursing (6185)
- Sociology (5614)
- Food Science (5480)
- Communication (5466)
- Biology (4673)
- Psychology (4609)
- Business (4491)
- Agronomy and Crop Sciences (4158)
- History (4070)
- Diseases (3783)
- Agricultural Science (3746)
- Public Affairs, Public Policy and Public Administration (3697)
- Earth Sciences (3654)
- Environmental Sciences (3584)
- Mass Communication (3218)
- Institution
-
- University of Nebraska - Lincoln (10898)
- Utah State University (6098)
- University of Kentucky (5853)
- University of New Hampshire (4372)
- Louisiana State University (4162)
-
- University of South Florida (4155)
- University of New Mexico (3838)
- California Polytechnic State University, San Luis Obispo (3818)
- South Dakota State University (3639)
- The Texas Medical Center Library (3497)
- Murray State University (3274)
- TÜBİTAK (3209)
- University of Mississippi (3102)
- University of Arkansas, Fayetteville (3020)
- San Jose State University (2949)
- University of North Dakota (2728)
- Washington University School of Medicine (2685)
- University of Montana (2660)
- University of Alabama at Birmingham (2603)
- Nova Southeastern University (2482)
- University of Rhode Island (2429)
- Walden University (2390)
- Western Kentucky University (2358)
- Clemson University (2098)
- Aga Khan University (2020)
- Eastern Illinois University (1976)
- Southern Illinois University Carbondale (1953)
- West Virginia University (1943)
- University of South Carolina (1919)
- Edith Cowan University (1884)
- Keyword
-
- Newspaper (4203)
- Humans (3663)
- Nutrition (3121)
- Obesity (2931)
- Female (2013)
-
- Education (1866)
- Newsletter (1834)
- Spartan Daily (1741)
- Male (1683)
- Health (1578)
- Diet (1475)
- Children (1365)
- Exercise (1341)
- Physical activity (1310)
- Agriculture (1257)
- Student newspaper (1188)
- Diabetes (1117)
- Animals (1109)
- Adult (1108)
- Child (1035)
- COVID-19 (1008)
- Bowling Green State University (986)
- Public health (941)
- Pregnancy (925)
- UAB (922)
- English (887)
- Food (862)
- EIU (854)
- News (818)
- United States (815)
- Publication Year
-
- 2026 (6736)
- 2025 (10487)
- 2024 (11604)
- 2023 (10920)
- 2022 (10510)
-
- 2021 (10796)
- 2020 (10627)
- 2019 (9647)
- 2018 (9168)
- 2017 (9027)
- 2016 (8568)
- 2015 (8124)
- 2014 (7441)
- 2013 (7105)
- 2012 (6749)
- 2011 (5772)
- 2010 (5261)
- 2009 (4661)
- 2008 (4028)
- 2007 (3650)
- 2006 (3545)
- 2005 (3163)
- 2004 (2827)
- 2003 (2653)
- 2002 (2463)
- 2001 (2332)
- 2000 (2291)
- 1999 (2057)
- 1998 (2046)
- 1997 (1928)
- Publication
-
- Theses and Dissertations (5148)
- Electronic Theses and Dissertations (3226)
- Faculty Publications (2819)
- IGC Proceedings (1977-2023) (2270)
- Walden Dissertations and Doctoral Studies (2220)
-
- The Murray Ledger & Times (1768)
- Dissertations (1720)
- Spartan Daily (School of Journalism and Mass Communications) (1636)
- All Graduate Theses and Dissertations, Spring 1920 to Summer 2023 (1606)
- Food and Machinery (1588)
- Master's Theses (1453)
- Faculty, Staff and Student Publications (1387)
- Cal Poly Student Newspaper (1269)
- Graduate Theses and Dissertations (1256)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (1221)
- Journal of Extension (1210)
- Faculty, Staff and Students Publications (1156)
- All ETDs from UAB (1107)
- Saudi Medical Journal (1086)
- Theses (1058)
- Open Access Publications (1045)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (1042)
- Honors Theses (993)
- Masters Theses (976)
- Articles (925)
- Research outputs 2022 to 2026 (897)
- Daily Mississippian (all digitized issues) (882)
- International Journal of Exercise Science: Conference Proceedings (867)
- Faculty Scholarship (834)
- Open Access Dissertations (813)
- Publication Type
Articles 301 - 330 of 240073
Full-Text Articles in Entire DC Network
Effect Of Black Soldier Fly Larvae Meal (Hermetia Illucens) And Microbial Probiotics With Multi-Enzymes On Protein Efficiency Ratio, Metabolic Profile, And Immune Status Of Broiler Chickens, Ahmed Abd-Elaziz Abdallah, Mona. Mahmoud Ahmed, Mohamed Mowed Khalifah, Marwa Ramdan El-Deken, Bahaa Mohamed Abou-Shehema, Mohamed Elsaeid Farag, Afaf Bobaker Abu_Shouk, Reda Mohamed Zaki, Asmaa Ahmed Saad, Merfat Salah El-Deen, Mervat A. Berikaa
Effect Of Black Soldier Fly Larvae Meal (Hermetia Illucens) And Microbial Probiotics With Multi-Enzymes On Protein Efficiency Ratio, Metabolic Profile, And Immune Status Of Broiler Chickens, Ahmed Abd-Elaziz Abdallah, Mona. Mahmoud Ahmed, Mohamed Mowed Khalifah, Marwa Ramdan El-Deken, Bahaa Mohamed Abou-Shehema, Mohamed Elsaeid Farag, Afaf Bobaker Abu_Shouk, Reda Mohamed Zaki, Asmaa Ahmed Saad, Merfat Salah El-Deen, Mervat A. Berikaa
Journal of King Abdulaziz University: Meteorology, Environment and Arid Land Agriculture
Black soldier fly larvae meal (BSFLM; Hermetia illucens) has been authorized in the EU as an insect-derived protein for feed and is a promising alternative to soybean meal (SBM), with potential functional benefits attributed to lauric acid (LA), chitin, and bioactive peptides; however, evidence is limited regarding its interaction with probiotic–multi-enzyme complexes. Thus, we investigated whether replacing SBM with BSFLM, with or without a microbial probiotic and multi-enzyme blend (MPE). A total of 225 one-day-old Ross 308 chicks were allocated to nine treatments in a 3× 3 factorial design (five replicates of five chicks) from 1–38 d, using mash …
Newborn Screening Reduces Survival Disparities In Scid After Stem Cell Transplant: A Pidtc Report, Lena E Winestone, Brent R Logan, Xuerong Liu, Olatundun Williams, Elizabeth A Dunn, Monica S Thakar, Sharon A Kidd, Talal Mousallem, Morna J Dorsey, Richard J O'Reilly, Neena Kapoor, Lisa Forbes Satter, Malika Kapadia, Soma C Jyonouchi, Sharat Chandra, Christen L Ebens, Deepakbabu Chellapandian, Sonali Chaudhury, Karin Chen, Blachy J Dávila Saldaña, Ahmad Rayes, Troy C Quigg, Shanmuganathan Chandrakasan, Jeffrey J Bednarski, Kenneth B Desantes, Pierre Teira, Alfred P Gillio, Hesham Eissa, Alan P Knutsen, Victor M Aquino, Evan B Shereck, Theodore B Moore, Emi H Caywood, Mark T Vander Lugt, Jacob Rozmus, Larisa Broglie, Lolie C Yu, Ami J Shah, Avni Y Joshi, Rebecca H Buckley, Jasmeen Dara, Joseph H Oved, Hisham Abdel Azim, Caridad A Martinez, Susan Prockop, Kathleen E Sullivan, Jack J Bleesing, Michael D Keller, Lisa M Madden, Suhag Parikh, Shalini Shenoy, Christine M Seroogy, Tamar Rubin, Jennifer Licata, Jeffrey R Andolina, Donald B Kohn, Lauri Burroughs, Jennifer W Leiding, Rebecca A Marsh, Luigi D Notarangelo, Sung-Yun Pai, Troy R Torgerson, Michael A Pulsipher, Jennifer Heimall, Geoffrey D E Cuvelier, Linda M Griffith, Jennifer M Puck, Christopher C Dvorak, Morton J Cowan, Elie Haddad
Newborn Screening Reduces Survival Disparities In Scid After Stem Cell Transplant: A Pidtc Report, Lena E Winestone, Brent R Logan, Xuerong Liu, Olatundun Williams, Elizabeth A Dunn, Monica S Thakar, Sharon A Kidd, Talal Mousallem, Morna J Dorsey, Richard J O'Reilly, Neena Kapoor, Lisa Forbes Satter, Malika Kapadia, Soma C Jyonouchi, Sharat Chandra, Christen L Ebens, Deepakbabu Chellapandian, Sonali Chaudhury, Karin Chen, Blachy J Dávila Saldaña, Ahmad Rayes, Troy C Quigg, Shanmuganathan Chandrakasan, Jeffrey J Bednarski, Kenneth B Desantes, Pierre Teira, Alfred P Gillio, Hesham Eissa, Alan P Knutsen, Victor M Aquino, Evan B Shereck, Theodore B Moore, Emi H Caywood, Mark T Vander Lugt, Jacob Rozmus, Larisa Broglie, Lolie C Yu, Ami J Shah, Avni Y Joshi, Rebecca H Buckley, Jasmeen Dara, Joseph H Oved, Hisham Abdel Azim, Caridad A Martinez, Susan Prockop, Kathleen E Sullivan, Jack J Bleesing, Michael D Keller, Lisa M Madden, Suhag Parikh, Shalini Shenoy, Christine M Seroogy, Tamar Rubin, Jennifer Licata, Jeffrey R Andolina, Donald B Kohn, Lauri Burroughs, Jennifer W Leiding, Rebecca A Marsh, Luigi D Notarangelo, Sung-Yun Pai, Troy R Torgerson, Michael A Pulsipher, Jennifer Heimall, Geoffrey D E Cuvelier, Linda M Griffith, Jennifer M Puck, Christopher C Dvorak, Morton J Cowan, Elie Haddad
Faculty, Staff and Students Publications
Black race and Hispanic ethnicity are associated with higher mortality in severe combined immunodeficiency (SCID) following hematopoietic cell transplantation (HCT), though mechanisms remain unclear. We evaluated 796 children with SCID who received nonsibling HCT between 1982 and 2020 using data from the Primary Immune Deficiency Treatment Consortium. Overall survival for Black (aHR 2.47, 95%CI 1.64, 3.71) and Asian/Pacific Islander patients (aHR 1.82, 95%CI 1.00, 3.30) was significantly lower compared with non-Hispanic White patients, while Hispanic patients had lower event-free survival (aHR 1.83, 95%CI 1.27, 2.63) compared with non-Hispanic White patients. Even after adjusting for age and infection, Black patients with …
Protective Factors Among African American Offspring Of Teen Parents, Janelle Ewing
Protective Factors Among African American Offspring Of Teen Parents, Janelle Ewing
Walden Dissertations and Doctoral Studies
Adolescent pregnancy remains a major public health and social issue, but research has primarily focused on risk factors and not the protective factors that contribute to resilience among those who successfully break the cycle. This qualitative study explored protective factors that African American adult offspring of teenage parents identified as supporting them in avoiding teenage pregnancy and parenthood. The study was theoretically grounded in Bronfenbrenner’s ecological systems theory, which was used to explore the role of influence across environmental systems in participants’ developmental outcomes. The primary research question was “How do African American adult offspring of teenage parents describe the …
Prevalence And Characteristics Of Feline Pleural Effusion In Khon Kaen, Thailand: A 2024–2025 Study, Karn Yongvanit, Naruepon Kampa
Prevalence And Characteristics Of Feline Pleural Effusion In Khon Kaen, Thailand: A 2024–2025 Study, Karn Yongvanit, Naruepon Kampa
The Thai Journal of Veterinary Medicine
Pleural effusion (PE) is a life-threatening condition in cats that can cause severe respiratory compromise. Identification of the underlying etiology is essential for prognosis and treatment planning. This study investigated the prevalence and characteristics of diseases associated with feline pleural effusion in northeastern Thailand. Medical records of cats diagnosed with pleural effusion at the Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Khon Kaen University, Thailand, between January 2024 and January 2025 were retrospectively reviewed. Cases lacking a complete diagnostic workup were excluded. Diagnoses were confirmed using cytology or histopathology for neoplasia, echocardiography for heart disease, polymerase chain reaction (PCR) for …
Optimizing Research To Practice Translation Time Through The Mountain Model: A Delphi Study, Jayne Jennings Dunlap, Julee Waldrop, Staci Reynolds
Optimizing Research To Practice Translation Time Through The Mountain Model: A Delphi Study, Jayne Jennings Dunlap, Julee Waldrop, Staci Reynolds
International Nursing Research Congress (INRC)
Introduction: The Mountain Model (MM) is the first published framework to merge evidence-based practice and quality improvement (EBPQI) paradigms. The primary focus of the framework is to guide practitioners in healthcare and related settings with translating research for sustained practice improvements. The nurse-led MM is in use and being cited in the literature, however the efficacy of the MM is anecdotal and is not yet supported by empirical evidence for its validity.
Design: A Delphi study of currently practicing evidence-based practice (EBP) and quality improvement (QI) experts spanning eight patient-facing disciplines in healthcare was conducted in September and October 2025 …
Livedoid Vasculopathy In A Young Woman With Elevated Factor Viii And Lipoprotein(A): A Case Report With Consideration Of Future Pregnancy, Nicole Nudelman, Ann K. Valencia, Alex Fernandez, Paige Johnson, Jeffrey Valencia Uribe, Brian G. Nudelman
Livedoid Vasculopathy In A Young Woman With Elevated Factor Viii And Lipoprotein(A): A Case Report With Consideration Of Future Pregnancy, Nicole Nudelman, Ann K. Valencia, Alex Fernandez, Paige Johnson, Jeffrey Valencia Uribe, Brian G. Nudelman
Student Publications
Livedoid vasculopathy (LV) is a rare, chronic vascular disorder marked by painful, recurrent ulcerations that primarily affect the lower extremities. It is frequently associated with hypercoagulable states, although its pathophysiology remains incompletely understood. We present the case of a 25-year-old woman with a longstanding history of LV, elevated factor VIII, increased lipoprotein(a), recurrent kidney stones, and iron deficiency anemia who presented with worsening lower-extremity ulcerations. An extensive workup excluded other hypercoagulable and connective-tissue conditions, leaving elevated factor VIII and lipoprotein(a) as the most likely contributors to her disease. Although her symptoms initially resolved with treatment, they recurred over time, and …
Ai-Enabled Nudging For Nursing-Led Prevention And Health Equity, Pattama S. Ulrich, Katherine M. Pallas, Michael Joseph Dino, Jean W. Davis
Ai-Enabled Nudging For Nursing-Led Prevention And Health Equity, Pattama S. Ulrich, Katherine M. Pallas, Michael Joseph Dino, Jean W. Davis
International Nursing Research Congress (INRC)
Health systems face escalating burdens from physical inactivity, poor nutrition, and related noncommunicable diseases (NCDs), which disproportionately affect socioeconomically and clinically susceptible populations [1], [2]. Concurrently, artificial intelligence (AI), digital health technologies, and wearable devices are increasingly shaping health decision making and behavior change interventions [3], [4]. Nudge theory, grounded in behavioral economics, offers a noncoercive approach to influencing behavior through choice architecture while preserving individual autonomy [5], [6]. As AI enables nudges to become more personalized and scalable, conceptual clarity is needed to guide ethical, nurse-led applications that advance prevention and health equity [7], [8].
This work conceptually examines …
Prevalence Of Tooth Loss Among Older Adults With Oral Frailty: A Systematic Review And Meta-Analysis, Wei-Chun Lin
Prevalence Of Tooth Loss Among Older Adults With Oral Frailty: A Systematic Review And Meta-Analysis, Wei-Chun Lin
Articles in Press
No abstract provided.
Acute Liver Injury Likely Induced By Alpha Lipoic Acid Contained In Dietary Supplement, Simona Maksimyan, Jonathan V. Reyes, Kasim Kazbay, Farah K. Gazi
Acute Liver Injury Likely Induced By Alpha Lipoic Acid Contained In Dietary Supplement, Simona Maksimyan, Jonathan V. Reyes, Kasim Kazbay, Farah K. Gazi
Journal of Community Hospital Internal Medicine Perspectives
The rise in use of herbal and dietary supplements, which are regulated as food rather than as drugs by the Food and Drug Association, poses the risk of unknown and potentially severe side effects. We describe the case of acute liver injury, characterized by significant elevation in AST and ALT, likely induced by the consumption of an over-the-counter supplement containing alpha lipoic acid (ALA). Our patient trusted in a “natural” alternative to Western medicine for management of neuropathy, which was ultimately detrimental to her liver. An immediate and sustained improvement in liver enzyme levels was noted with discontinuation of the …
Prepregnancy Obesity Versus Excessive Gestational Weight Gain: A Comparative Evaluation Of Adverse Outcomes, Samuel Schultz, David Krantz, Matthew Blitz, Ashley Battarbee, Moti Gulersen
Prepregnancy Obesity Versus Excessive Gestational Weight Gain: A Comparative Evaluation Of Adverse Outcomes, Samuel Schultz, David Krantz, Matthew Blitz, Ashley Battarbee, Moti Gulersen
Department of Obstetrics and Gynecology Faculty Papers
Background/Objectives: Obesity and excessive gestational weight gain (EGWG) are known risk factors for adverse outcomes in pregnancy, but the comparative risk is less well defined and increasingly relevant in an era of increasing use of weight loss medications. We aimed to determine whether EGWG was associated with adverse maternal and neonatal outcomes, compared with prepregnancy obesity. Methods: Multicenter retrospective cohort study of pregnant patients who delivered a singleton within a single university health system from 2019–2024. Patients with missing prepregnancy body mass index (BMI) data, BMI < 18.5 kg/m2, or pregestational diabetes were excluded. Logistic regression with propensity score weights and g-computation were used to evaluate if the incidence of several adverse maternal and neonatal outcomes were impacted by prepregnancy obesity and gestational weight gain (GWG). p values were adjusted for multiple comparisons. Results: Among the 129,615 pregnancies included, 28,516 (22.0%) had prepregnancy obesity, 36,943 (28.5%) were overweight prior to pregnancy, and 64,156 (49.5%) had a normal BMI prior to pregnancy. When compared to patients with obesity, patients with normal prepregnancy BMI and EGWG had a lower risk of adverse maternal and neonatal outcomes, including gestational diabetes, gestational hypertension, preeclampsia, eclampsia, cesarean delivery, and postpartum hemorrhage, as well as large and small for gestational age birthweight, stillbirth, neonatal intensive care unit admission, neonatal mechanical ventilation, respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis, and sepsis. Beneficial effects were attenuated for patients with overweight prepregnancy BMI or for larger EGWG. Conclusions: Lower prepregnancy BMI, even with the potential unintended consequence of EGWG, may be more favorable than untreated prepregnancy obesity with regard to perinatal outcomes.
The Impact Of A Modified Hospital Elder Life Program On Delirium, Ashley Okray
The Impact Of A Modified Hospital Elder Life Program On Delirium, Ashley Okray
SIU Journal of Medical Science Scholarly Works
Background: Delirium, an acute state of fluctuating inattention and cognitive impairment, is prevalent among hospitalized older adults and associated with longer hospital stays, increased mortality, and significant healthcare costs. The Hospital Elder Life Program (HELP) was developed to reduce delirium through interventions addressing common risk factors. Although HELP has proven effective, many hospitals face challenges in implementing the program, leading to modified versions. This review examines recent studies using modified HELP to assess their impact on delirium prevention.
Methods: A literature search was conducted to identify studies from the last ten years that implemented modified HELP programs. Relevant studies …
Intermittent Fasting: Effectiveness In Lowering Bmi Of Postmenopausal Women, Becky Hanna
Intermittent Fasting: Effectiveness In Lowering Bmi Of Postmenopausal Women, Becky Hanna
SIU Journal of Medical Science Scholarly Works
ABSTRACT
Purpose: The purpose of this article is to review the intervention of an intermittent fasting diet in postmenopausal women with a BMI greater than or equal to 30 kg/m2 in comparison with a nonintervention diet for lowering BMI.
Method: A literature search was performed utilizing PubMed. Keywords such as intermittent fasting, fasting, obesity, weight loss, time-restricted feeding, postmenopausal, and menopause were used in the search. The search was limited to free full articles with dates of 2019-2024. A few combinations of terms were used to focus the results of the search. Articles examining exercise plus intermittent fasting as …
Adjunctive Probiotic Use During Antibiotic Exposure In Very Preterm Infants: A Narrative And Translational Review, Mustafa Törehan Aslan, Mustafa Altındiş, Fahri Ovalı
Adjunctive Probiotic Use During Antibiotic Exposure In Very Preterm Infants: A Narrative And Translational Review, Mustafa Törehan Aslan, Mustafa Altındiş, Fahri Ovalı
Journal of Pediatric Infectious Diseases
Infants born before 32 weeks of gestation are highly susceptible to late-onset sepsis because of immune immaturity, impaired intestinal barrier function, and frequent broad-spectrum antibiotic exposure. Whether probiotics should be continued or initiated during antibiotic therapy remains unresolved and is often conflated with routine prophylaxis in stable infants. This SANRA-guided structured narrative and translational review synthesized clinical, microbiome, resistome, mechanistic, and safety evidence identified in PubMed/MEDLINE, Scopus, and Web of Science through July 1, 2026, across three contexts: stable antibiotic overlap, suspected sepsis, and confirmed or unstable sepsis. Pooled prophylactic analyses suggest a small, heterogeneous reduction in late-onset infection (risk …
Age-Dependent Variations In Clinical Presentation, Laboratory Parameters, And Coronary Outcomes In Kawasaki Disease: A 10-Year Retrospective Cohort Study Of 480 Pediatric Patients In Eastern China, Zhuying Zhou, Chen Wang, Aole Li, Saeed Saboor, Xiaoli Li, Xiaowei Li, Xianmei Huang, Chunming Jiang
Age-Dependent Variations In Clinical Presentation, Laboratory Parameters, And Coronary Outcomes In Kawasaki Disease: A 10-Year Retrospective Cohort Study Of 480 Pediatric Patients In Eastern China, Zhuying Zhou, Chen Wang, Aole Li, Saeed Saboor, Xiaoli Li, Xiaowei Li, Xianmei Huang, Chunming Jiang
Journal of Pediatric Infectious Diseases
Objective: This study investigated the age-dependent clinical characteristics of Kawasaki disease (KD) in pediatric patients and assessed the influence of age on disease presentation and outcomes. Methods: A retrospective analysis was conducted of 480 children diagnosed with KD who were admitted to Hangzhou First People's Hospital between 2013 and 2022. Subjects were stratified into two cohorts based on age: <2 years and 2-14 years). Demographic data, clinical manifestations, laboratory parameters, comorbidities, and coronary artery abnormalities were comprehensively evaluated across the age groups. Results: Time from symptom onset to diagnosis was significantly prolonged in the older cohort (z=-2.70, P=0.007). The incidence of cervical lymphadenopathy was markedly higher in older children (χ²=15.12, P<0.001), while peripheral extremity changes were significantly less frequent (χ²=5.79, P=0.016). The younger cohort exhibited significantly elevated platelet counts, alanine aminotransferase, and NT-proBNP levels compared to older patients (z=-3.57, P<0.001; z=-2.39, P=0.02; z=-3.59, P<0.001, respectively). Coronary artery dilatation and aneurysm formation occurred more frequently in younger patients (z=7.70, P=0.006; z=14.63, P<0.001). However, coronary artery recovery rates following intravenous immunoglobulin therapy showed no significant inter-group differences (P>0.05). Conclusions: The clinical presentation of KD demonstrates significant age-dependent variation. Clinicians should maintain a high index of suspicion for KD in older children presenting with fever and cervical lymphadenopathy. In younger patients with KD, close monitoring of hepatic function, platelet …2>
Current Advances In Cancer Immunotherapy: Mechanisms, Therapeutic Strategies, Challenges, And Future Perspectives, Mohamed E. Abd El-Hack, Mahmoud Moustafa, Mahmoud Kamal, Vincenzo Tufarelli, Muhammad Arif, Laith Aldabbagh
Current Advances In Cancer Immunotherapy: Mechanisms, Therapeutic Strategies, Challenges, And Future Perspectives, Mohamed E. Abd El-Hack, Mahmoud Moustafa, Mahmoud Kamal, Vincenzo Tufarelli, Muhammad Arif, Laith Aldabbagh
Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Cancer immunotherapy has emerged as a transformative therapeutic strategy that harnesses the host immune system to recognize and eliminate malignant cells. This review provides a comprehensive overview of current immunotherapeutic approaches, including immune checkpoint inhibitors (ICIs), monoclonal antibodies (mAbs), cancer vaccines, dendritic cell (DC)-based vaccines, chimeric antigen receptor (CAR)-T cell therapy, and oncolytic virus therapy. The mechanisms of action, therapeutic applications, and clinical benefits of each modality are discussed. Monoclonal antibodies selectively target tumor-associated antigens, whereas ICIs restore antitumor immunity by blocking inhibitory immune checkpoints. Cancer vaccines and DC-based vaccines enhance antigen-specific immune responses, while CAR-T cell therapy employs genetically …
Involvement Of Melatonin In The Regulation Of Reactive Oxygen Species Levels In Plants, Bariş Uzi̇lday, Oğuzhan Yilmaz, Tolga Yalçinkaya, Zehra Özgecan Tanyolaç, İsmai̇l Türkan, Rengi̇n Özgür Uzi̇lday
Involvement Of Melatonin In The Regulation Of Reactive Oxygen Species Levels In Plants, Bariş Uzi̇lday, Oğuzhan Yilmaz, Tolga Yalçinkaya, Zehra Özgecan Tanyolaç, İsmai̇l Türkan, Rengi̇n Özgür Uzi̇lday
Turkish Journal of Botany
Abiotic stress conditions impair plant metabolism partly by inducing the excessive production of reactive oxygen species (ROS). Melatonin, a multifunctional indoleamine, has emerged as an important regulator of plant responses to oxidative stress. This review highlights recent findings on the interactions among phytomelatonin, ROS homeostasis, antioxidant metabolism, photosynthetic protection, stress priming, and abiotic stress tolerance. We discuss how melatonin modulates the antioxidative response under diverse stress conditions and evaluate its effects on photosynthetic performance, ROS signaling, and membrane stability. Special attention is given to priming studies showing that melatonin pretreatment can improve stress tolerance. Emerging evidence from plant tissue culture …
Drought Priming Improves Waterlogging Tolerance In Alfalfa, But Less Effectively Than Waterlogging Priming, Gürkan Demi̇rkol, Ni̇lüfer Kara
Drought Priming Improves Waterlogging Tolerance In Alfalfa, But Less Effectively Than Waterlogging Priming, Gürkan Demi̇rkol, Ni̇lüfer Kara
Turkish Journal of Botany
Waterlogging severely restricts growth and productivity in alfalfa (Medicago sativa L.), necessitating effective strategies to improve stress tolerance. This study investigated whether drought priming or waterlogging priming could enhance tolerance to subsequent waterlogging stress in the alfalfa cultivar “Bilensoy-80”. Plants were subjected to drought priming, waterlogging priming, or no priming prior to progressive waterlogging stress for 0, 4, 8, 12, 16, and 20 days. Waterlogging priming consistently alleviated growth inhibition, maintained chlorophyll content, and reduced oxidative damage under prolonged stress. Drought priming was associated with partial cross-tolerance, particularly through improved root growth, plant water status, and oxidative stress responses, although …
Red Light Accelerates Adventitious Root Primordium Initiation And Differentiation In Phoebe Bournei Cuttings By Modulating Auxin Signaling And Hormonal Balance, Yuewang Niu, Yuanyang Bi, Chenyu Gong, Shipin Chen
Red Light Accelerates Adventitious Root Primordium Initiation And Differentiation In Phoebe Bournei Cuttings By Modulating Auxin Signaling And Hormonal Balance, Yuewang Niu, Yuanyang Bi, Chenyu Gong, Shipin Chen
Turkish Journal of Botany
Adventitious root formation in stem cuttings of Phoebe bournei, an economically and ecologically significant woody species, is a major bottleneck in clonal propagation. To elucidate the impact of spectral quality on early adventitious root development, we characterized the morphological, hormonal, and transcriptomic dynamics of primordium initiation and differentiation under white, red, and blue light. Under red light, cuttings exhibited the earliest and most pronounced formation of white filamentous structures at lenticels, indicative of root primordium initiation, as early as 20 days after cutting, whereas white and blue light treatments showed delayed responses. Paraffin section analysis confirmed the induced origin of …
Isolated Perianal Fistulizing Crohn's Disease In Contemporary Clinical Practice: A Multicenter Ecco-Confer Cohort Study, Kumarini Basnayake, Parakkal Deepak, Sami Samaan, Et Al.
Isolated Perianal Fistulizing Crohn's Disease In Contemporary Clinical Practice: A Multicenter Ecco-Confer Cohort Study, Kumarini Basnayake, Parakkal Deepak, Sami Samaan, Et Al.
2020-Current year OA Pubs
BACKGROUND AND AIMS: Isolated perianal fistulizing Crohn's disease (IPFCD) is an uncommon presentation of Crohn's disease with an uncertain natural history. We aimed to characterize contemporary diagnostic strategies, management approaches, and long-term outcomes, including progression to luminal Crohn's disease.
METHODS: We conducted a retrospective multicenter cohort study across 25 centers within the ECCO-CONFER network. Adult patients with IPFCD and no evidence of luminal Crohn's disease at baseline were included. The primary outcome was progression to luminal Crohn's disease. Secondary outcomes included clinical and radiological fistula response and patterns of medical and surgical management. Time-to-event analyses were performed using Kaplan-Meier methods. …
Patient-Centered Summarization Framework For Ai Clinical Summarization: Mixed Methods Study, Maria Lizarazo Jimenez, Ana Gabriela Claros, Kieran Green, David Toro-Tobon, Felipe Larios, Sheena Asthana, Camila Wenczenovicz, Kerly Guevara Maldonado, Luis Vilatuna-Andrango, Ana Cristina Proano, Satya Sai Sri Bandi, Shubhangi Bagewadi, Megan E. Branda, Misk Al Zahidy, Saturnino Luz, Mirella Lapata, Juan P. Brito, Oscar J. Ponce-Ponte
Patient-Centered Summarization Framework For Ai Clinical Summarization: Mixed Methods Study, Maria Lizarazo Jimenez, Ana Gabriela Claros, Kieran Green, David Toro-Tobon, Felipe Larios, Sheena Asthana, Camila Wenczenovicz, Kerly Guevara Maldonado, Luis Vilatuna-Andrango, Ana Cristina Proano, Satya Sai Sri Bandi, Shubhangi Bagewadi, Megan E. Branda, Misk Al Zahidy, Saturnino Luz, Mirella Lapata, Juan P. Brito, Oscar J. Ponce-Ponte
School of Nursing and Midwifery
Background: Large language models (LLMs) are increasingly demonstrating the potential to reach human-level performance in generating clinical summaries from patient-clinician conversations. LLMs are usually evaluated against clinical summaries that focus mainly on patients’ biology and not on their biography (eg, preferences, values, wishes, and concerns). To achieve patient-centered care, artificial intelligence clinical summarization must incorporate patient-centered domains, implemented through patient-centered summaries (PCSs). Objective: This study aimed to develop a framework to generate PCS that capture patients’ values, preferences, and wishes while ensuring clinical utility for clinicians, and assess if current open-source LLMs can achieve human-level performance in generating PCS. Methods: …
Healthcare System Barriers To Somali Refugees In Kenya, Zahra Sharif Hashim
Healthcare System Barriers To Somali Refugees In Kenya, Zahra Sharif Hashim
Walden Dissertations and Doctoral Studies
Access to health care is a fundamental right of every refugee, yet gaps in implementing Kenya's Refugees Acts of 2006 and 2021 continue to limit access for Somali refugees in Dadaab camp. Existing research has documented resource constraints, movement restrictions, and other barriers to refugee health care, but how policy implementation gaps shape access in Dadaab has not been well explored. The purpose of this qualitative descriptive study was to understand barriers to health care access for Somali refugees resulting from gaps in implementing Kenya's refugee health policies. The narrative policy framework guided the study. Data from semistructured interviews with …
Artificial Intelligence In Food Engineering For Food Safety, Quality Assurance, And Human Health, Ayad Abbood Abdulhasan, A. M. Mustafa, F. F. Sayyid, Marwan B. Hussein, Mohanad Muzahem Khalaf
Artificial Intelligence In Food Engineering For Food Safety, Quality Assurance, And Human Health, Ayad Abbood Abdulhasan, A. M. Mustafa, F. F. Sayyid, Marwan B. Hussein, Mohanad Muzahem Khalaf
AUIQ Technical Engineering Science
Artificial intelligence (AI) is increasingly reshaping food engineering by providing data-driven tools for safeguarding food safety, ensuring quality assurance, and improving human health outcomes. This review synthesizes current evidence on the application of machine learning, deep learning, computer vision, and the Internet of Things (IoT) across the food production continuum, from raw material inspection to consumer-facing nutrition guidance. We examine how convolutional neural networks, hyperspectral imaging, and sensor-fusion approaches enable rapid, non-destructive detection of contaminants and pathogens, and how predictive models support shelf-life estimation and quality grading. We further discuss AI-enabled traceability systems, including blockchain-integrated supply chains, and the growing …
Management And Outcomes Of Pediatric Necrotizing Pneumonia In The United States, Manette Ness-Cochinwala, Kaitlin Kobaitri, Paul Martinez, Balagangadhar R. Totapally
Management And Outcomes Of Pediatric Necrotizing Pneumonia In The United States, Manette Ness-Cochinwala, Kaitlin Kobaitri, Paul Martinez, Balagangadhar R. Totapally
Journal of Pediatric Intensive Care
Introduction: Necrotizing pneumonia, an uncommon but serious condition in children, lacks comprehensive multicenter pediatric data. The objective was to assess treatment strategies and outcomes of necrotizing pneumonia in children. Methods: The Pediatric Health Information System was queried for patients, ages 30 days to 19 years, with lung necrosis. Children who received alteplase were compared with those who did not. The chi-square test, Mann-Whitney-U test, multivariable regression analysis, and propensity score matching were performed. Results: Out of a total of 2,177 children with necrotizing pneumonia, 59% had pleural effusion. A complex chronic condition (CCC) was present in 51% of patients. Resources …
Enteral Nutrition Practices During Non-Invasive Ventilation In Critically Ill Children: Secondary Analysis Of The Niv Dex En Study, Charlene P. Pringle, Peter Chang, Joie Cavazos, Tristan Dorn, Christine Allen, K. Leslie Avery, Torrey Baines, Samantha Gee, Nekaiya Jacobs, Jodi J. Bloxham, Elizabeth M. Brothers, Elizabeth Elliott, Shannon Faulkinberry, Emily F. Goldhar, Stephanie C. Hsu, K. Meghan Kendall, Christine Koshel, Ada T. Lin, Kristin K. Magner, Krishna S. Siruguppa, Kitman Wai, Anna Wanzenberg, Ann-Marie Brown
Enteral Nutrition Practices During Non-Invasive Ventilation In Critically Ill Children: Secondary Analysis Of The Niv Dex En Study, Charlene P. Pringle, Peter Chang, Joie Cavazos, Tristan Dorn, Christine Allen, K. Leslie Avery, Torrey Baines, Samantha Gee, Nekaiya Jacobs, Jodi J. Bloxham, Elizabeth M. Brothers, Elizabeth Elliott, Shannon Faulkinberry, Emily F. Goldhar, Stephanie C. Hsu, K. Meghan Kendall, Christine Koshel, Ada T. Lin, Kristin K. Magner, Krishna S. Siruguppa, Kitman Wai, Anna Wanzenberg, Ann-Marie Brown
Journal of Pediatric Intensive Care
Introduction: Despite the widespread use of non-invasive ventilation (NIV) in pediatric intensive care units (PICUs), little has been published regarding enteral nutrition (EN) in this setting. This pre-planned secondary analysis of the Association of Enteral Nutrition and Dexmedetomidine Usage for Critically Ill Children Requiring Non-Invasive Ventilation study aimed to describe current feeding practices during NIV in a large sample, including differences in timing, energy and protein delivery across NIV modes and interfaces. Methods: Secondary analysis of a retrospective study of 1763 patients acutely supported with NIV over one year in fourteen PICUs in the United States. Results: 1065 subjects (60.4%) …
Understanding The Educational Needs Of Primary Care Providers Around Post-Intensive Care Syndrome In Pediatrics (Pics-P)- A Cross-Sectional Survey, Sarah Rubin, Katie Joy, Sarah Springer, Ericka Fink, Jessica Jarvis
Understanding The Educational Needs Of Primary Care Providers Around Post-Intensive Care Syndrome In Pediatrics (Pics-P)- A Cross-Sectional Survey, Sarah Rubin, Katie Joy, Sarah Springer, Ericka Fink, Jessica Jarvis
Journal of Pediatric Intensive Care
Introduction: Pediatric Intensive Care Unit (PICU) survivors often experience new functional impairments after hospital discharge, known as Post-Intensive Care Syndrome in pediatrics (PICS-p). Unaddressed impairments may lead to life-long developmental delays. Primary Care Providers (PCPs) are responsible for recognizing and managing PICS-p. Understanding PCP preparedness for this role is critical to optimizing recovery after critical illness. Objectives: To characterize PCP’s 1) awareness and understanding of PICS-p, 2) access to resources for PICS-p impairments, 3) barriers to post-PICU care, 4) preferred educational strategies. Methods: Cross-sectional survey of university-affiliated PCPs from October to December 2023. An anonymous, 18-item Microsoft Forms survey was …
Designing Smart Charity: A Tri-Tiered Systems Engineering Framework For Global Capital Allocation, Christopher L. Eckes
Designing Smart Charity: A Tri-Tiered Systems Engineering Framework For Global Capital Allocation, Christopher L. Eckes
Defensive Publications Series
Traditional philanthropic capital allocation models consistently exhibit binary systemic failure modes: low-velocity palliative aid loops that induce sovereign moral hazards, or hyper-insulated frontier engineering moonshots that leave present-day socio-economic baselines highly vulnerable to exogenous shocks. This specification introduces the Tri-Tiered Systems Engineering Framework for Philanthropy, an objective, non-weaponizable technical model that treats charitable giving as an essential infrastructure risk-management protocol rather than a speculative moral luxury.
By segmenting capital allocation into three distinct, non-interchangeable tiers—Palliative Stabilization (Tier 1), Environmental Upgrades (Tier 2), and Frontier Innovation (Tier 3)—this architecture models global civilizational utility as a complex physical system. We leverage historical …
Sports Injuries You May Overlook, Sarah Gubara, Greg Canty
Sports Injuries You May Overlook, Sarah Gubara, Greg Canty
Pediatrics in Practice: A CME Podcast
Could this recurring pain or sudden limp mean something more than a sprain? Greg Canty, MD, Medical Director, Sports Medicine Center at Children's Mercy, walks through how to recognize concerning pediatric sports injuries that are often missed. This episode covers X‑ray‑negative knee injuries (patella dislocation, ACL tear, meniscus), pelvic avulsion and transitional ankle growth plate fractures, and overuse conditions such as gymnast wrist, spondylolysis, Little League elbow, and shoulder impingement. Dr. Canty outlines practical red flags—swelling, inability to weight‑bear, point tenderness, pain persisting beyond two weeks in single‑sport athletes, and declines in participation—and explains how assessing training load, sleep, nutrition, …
Community Strengths: A Global Partnership To Support Children With Disabilities In Ghana, Christine Rae Platt, Michael Thomas, Brandon Thatcher, Ashlee Johnson
Community Strengths: A Global Partnership To Support Children With Disabilities In Ghana, Christine Rae Platt, Michael Thomas, Brandon Thatcher, Ashlee Johnson
International Nursing Research Congress (INRC)
Purpose: To conduct a community-based needs assessment with Ghanaian caregivers of children with disabilities and collaboratively develop strategies to address identified gaps.
Methods: A community-based participatory action research approach, between a U.S. university’s global health initiative and the Africa Interdisciplinary Research Group, was used to engage Ghanaian community members including mothers from a cerebral palsy support group, a schoolteacher, a school board representative, pediatric and community health nurses, a psychiatric nurse practitioner, an orphanage caregiver, and a reverend overseeing the orphanage. Data were collected through focus groups or individual interviews. Thematic analysis identified core themes reflecting needs and community strengths, …
Precision Approaches Improve Community Health, Roger A. Rennekamp, David Buys
Precision Approaches Improve Community Health, Roger A. Rennekamp, David Buys
Journal of Extension
Recent advances in data science provide Extension practitioners with access to data sorted by zip code, census tract, or neighborhood. Such hyper-local data now allows Extension personnel to assess community needs and assets at a more granular level and focus their work on the people and communities of greatest need. In this article, we introduce an approach we refer to as precision public health. Using such a precision approach to community assessment and, ultimately, programming can save money, increase the likelihood of producing measurable results, and create more manageable workloads for county-based Extension personnel.