Digital Commons Network^™

Community-Based Respiratory Health Measures In Children And Young People With Cerebral Palsy: A Scoping Review, Rachel Knight Lozano, Harriet Shannon, Jonathan Gilby, Sian Goddard, Leanne Turner, Jonathan Marsden

School of Health Professions

Aim: To identify, map, and describe outcome measurement domains and instruments used within a community setting to assess respiratory health in children and young people aged 1 to 18 years, diagnosed with cerebral palsy (CP). Method: A scoping review methodology informed structured searches in nine databases, grey literature, and registries, conducted in August 2021 (updated in February 2023). Articles were screened for eligibility by two independent researchers. Any outcome measurement instruments used to assess respiratory health or associated impact were extracted, categorized, and mapped to health and health-related domains of the International Classification of Functioning, Disability, and Health. Results: Seventy-six …

Unlocking The Power Of Ketogenic Diets: Evidence-Based Insights Into Weight Loss, Diabetes, And Beyond, Doreen Ugwu, Ana M. Palacios

Eagles Talking About the Public’s Health

No abstract provided.

Beyond Borders: Exploring The Lived Experiences Of International Migrant Women In Nigeria, A Deep Dive Into Healthcare Realities And Utilization, Juliet Nwafor, Rowland Edet, Ezebunwa Nwokoch

Department of Sociology: Faculty Publications

This study explored access to and utilization of healthcare facilities among migrant women in an urban slum community in Nigeria, focusing on factors influencing healthcare-seeking behaviors and the implications for public health interventions. A qualitative case study-oriented research design was employed, involving in-depth interviews with 21 migrant women of reproductive age and 4 key informant interviews with healthcare workers in the Ayobo community of Lagos State, Nigeria. Data collection occurred from June to September 2018, and thematic analysis was used to interpret the findings. Three main themes emerged: living conditions, pattern of healthcare utilization, and factors influencing accessibility and utilization …

A Global Scoping Review Of Adaptations In Nurturing Care Interventions During The Covid-19 Pandemic, Lidia Godoi, Simone Schenkman, Ana A Baumann, Aylene Bousquat, Gabriela Buccini

2020-Current year OA Pubs

BACKGROUND: During the COVID-19 pandemic, children faced a disproportionate burden of malnutrition and poor health outcomes. Nurturing care interventions (NCIs) including actions toward good health, adequate nutrition, responsive care, opportunities for early learning, and security and safety are critical for promoting equity. Due to the need for evidence-based responses and preparedness, we analyzed adaptations in NCIs' implementation strategies during COVID-19 according to the Framework for Reporting Adaptations and Modifications to Evidence-based Implementation Strategies (FRAME-IS).

METHOD: We conducted a global scoping review including peer-reviewed and non-peer-reviewed literature. The databases searched were PubMed, Embase, Scopus, BVS, Scielo, and Web of Science. This …

Sexual Dimorphism In Hepatic Ppar Alpha And Cyp4a12a Expression Is Associated With Reduced Development Of Drug-Induced Non-Alcoholic Steatohepatitis In Female Il-33-/- Mice, Chloe Thomas, Dolores B Njoku

2020-Current year OA Pubs

Males are at higher risk for developing metabolic dysfunction-associated steatohepatitis (MASH) than females; however, mechanisms mediating sexual dimorphism in MASH development are not completely understood. Nutrition-based mouse models suggest that dysregulated fatty acid biosynthesis promotes MASH. Drugs recapitulate MASH without diet variabilities. This brief report investigates associations of sexual dimorphism with male susceptibility to MASH utilizing a drug-induced MASH model and focuses on very-long-chain fatty acid biosynthesis pathways. We assessed male and female mouse livers at 5 and 15 weeks following MASH induction by immunizations and age-matched un-immunized controls utilizing Western blot. Our results suggest that PPAR alpha and CYP4a12a …

Delayed Macrophage Targeting By Clodronate Liposomes Worsens The Progression Of Cytokine Storm Syndrome, Kunjan Khanna, Emily Eul, Hui Yan, Roberta Faccio

2020-Current year OA Pubs

Excessive macrophage activation and production of pro-inflammatory cytokines are hallmarks of the Cytokine Storm Syndrome (CSS), a lethal condition triggered by sepsis, autoimmune disorders, and cancer immunotherapies. While depletion of macrophages at disease onset protects from lethality in an infection-induced CSS murine model, patients are rarely diagnosed early, hence the need to characterize macrophage populations during CSS progression and assess the therapeutic implications of macrophage targeting after disease onset. In this study, we identified MHCII

Variation In Mainland Northwest Territories Late-Winter Muskox (Ovibos Moschatus) Density Estimations And Habitat Associations Above And Below Treeline., Charlotte Rentmeister

Theses and Dissertations (Comprehensive)

The Arctic and Sub-Arctic ecosystems are seeing accelerated changes in temperature, landcover, and consequently species abundance and distributions. Reliable distributions, and associated population density estimates, are essential for effective conservation and management efforts. Growing concerns from northern communities regarding the relationship between muskox and declining caribou populations strengthens the need for updated information on muskox populations within mainland Northwest Territories (NWT). The first objective for my research was to quantify and map updated winter estimates of abundance, density, and distribution of muskoxen within three recent survey regions located in mainland NWT, using a multiple covariate distance sampling method (MCDS), paired …

In Vivo Scanning Laser Fundus And High-Resolution Oct Imaging Of Retinal Ganglion Cell Injury In A Non-Human Primate Model With An Activatable Fluorescent-Labeled Tat Peptide Probe, Xudong Qiu, Seth T Gammon, Carol Rasmussen, Federica Pisaneschi, Charlene B Y Kim, James Ver Hoeve, Steven W Millward, Edward M Barnett, T Michael Nork, Paul L Kaufman, David Piwnica-Worms

Faculty, Staff and Student Publications

The optical imaging agent TcapQ488 has enabled imaging of retinal ganglion cell (RGC) injury in vivo in rodents and has potential as an effective diagnostic probe for early detection and intervention monitoring in glaucoma patients. In the present study, we investigated TcapQ488 in non-human primates (NHPs) to identify labeling efficacy and early signals of injured RGC, to determine species-dependent changes in RGC probe uptake and clearance, and to determine dose-limiting toxicities. Doses of 3, 6, and 12 nmol of TcapQ488 were delivered intravitreally to normal healthy NHP eyes and eyes that had undergone hemiretinal endodiathermy axotomy (HEA) in the inferior …

Examining Seasonality Of Zooplankton Communities And Water Quality In Yellowknife Area Lakes, Northwest Territories, Nicole Andreola

Theses and Dissertations (Comprehensive)

Frame Lake, located in Yellowknife, Northwest Territories, is one of the city's main attractions. Unfortunately, urbanization and eutrophication have led to a decline in water quality in the lake. Eutrophication has caused a buildup of organic matter in sediments on the bottom of the lake, which can cause a high oxygen demand when processed by aerobic bacteria. Dissolved oxygen levels are high during the summer, but ice shields the lake from gas exchange with the atmosphere, leading to winter anoxia. This oxygen depletion makes it impossible for sensitive aquatic life, such as fish, to survive in the lake over the …

“You Do Not Need To Be Skinny Or Look Like An Athlete To Still Live A Healthy Life”: Exploring Anti-Fat Bias Within Health-Related Undergraduate Programs, Maddie Katz

Theses and Dissertations (Comprehensive)

Anti-fat bias negatively influences well-being, particularly for fat people. This bias is present in healthcare and fitness contexts, where emphasis on bodies and weight are salient. Healthcare and fitness professionals often re-learn anti-fat bias in their education through a weight-centric paradigm of health, which frames weight as a primary indicator of health (good or bad), an individual responsibility, and a direct reflection of individual behavioural choices (i.e., diet and exercise). The failure to control one’s weight within societally acceptable levels is seen as a moral failure rather than resulting from complex factors relating to the social determinants of health (i.e., …

Assessing Road Dust Impacts On Macroinvertebrates Community Structure In Canadian Arctic Lakes, Hong Yi Gao

Theses and Dissertations (Comprehensive)

In the Canadian Arctic, unpaved gravel roads are essential for regional accessibility but are also potential sources of road dust runoff. My study investigated the impacts of road dust from the Dempster and Inuvik-Tuktoyaktuk Highways on adjacent freshwater ecosystems, focusing on water quality parameters and macroinvertebrate communities. Using a stratified random sampling design, 18 lakes were studied across two regions (boreal forest and tundra) and three distance categories from the road (0-300 m, 300-600 m, and > 600 m). Contrary to my initial hypotheses, findings revealed no significant differences in water quality or invertebrate communities relative to distance from the road. …

Collateral Consequences And The Bars Outside Of Incarceration: An Assessment Of Massachusetts State Policies Surrounding Reentry, Nisa Rivera

Undergraduate Theses and Capstone Projects

How do Massachusetts policies impose collateral consequences for people with felony convictions and/or periods of incarceration? Previous research shows that having some form of a criminal record can make it harder to obtain housing, employment, and other sectors of life. Research was conducted to examine how Massachusetts policies restrict access to necessary resources that would otherwise allow returning citizens to become self-sufficient. Assessments were made regarding civic engagement, housing, higher education, employment, occupational licensing, and government assistance. The presence of a collateral consequence was based on whether a felony conviction was taken into consideration or served as a disqualifier, whether …

Ribosome Hibernation Factor Induces Antibiotic Persisters Of Mycobacterium Tuberculosis In Neutrophil-Rich Lung Lesions, Jamie Corro

Electronic Theses & Dissertations (2024 - present)

Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is a prescient global health threat and the leading cause of death by an infectious agent. Treatment of Mtb infection involves administering 2-4 antibiotics for a minimum of 6 months. This extended drug regimen is required to target a subpopulation of persistent bacilli. As their name implies, these bacteria can “persist” by acquiring nonhereditary and transient antibiotic tolerance. Although the precise mechanism is unknown, it’s often attributed to slowing cellular growth and metabolic processes. During zinc deprivation, bacteria can remodel their ribosomes by replacing their zinc-binding paralogues containing the CXXC motif (C+) …

The Transdiagnostic Role And Measurement Of Cognitive Inflexibility Across Understudied Eating Disorder Groups: A Multi-Method Investigation, Mckenzie Miller

Electronic Theses & Dissertations (2024 - present)

Cognitive inflexibility is an established transdiagnostic executive function deficit that maintains a wide array of psychiatric conditions. Eating disorders (ED) are serious, life-threatening conditions that remain underdiagnosed and understudied across diverse demographic groups. There is growing evidence for a role of cognitive inflexibility in driving hallmark ED symptoms, particularly in anorexia nervosa. Treatments targeting cognitive inflexibility may improve the currently poor outcomes of these conditions. To date, the role of cognitive inflexibility remains to be examined across demographically and diagnostically diverse ED groups. The first two studies presented here examine associations between cognitive inflexibility and symptom presentation in two relatively …

Effects Of Grant Termination For Orphans, Vulnerable Children And Their Caregivers In Windhoek, Namibia, Miriam Winnie Hasheela

Electronic Theses & Dissertations (2024 - present)

Namibia faces complex child welfare policy dilemmas in providing sustainable support for the increasing number of AIDS-orphaned youth transitioning into adulthood. While Orphan and Vulnerable Children (OVC) social grants have played a vital role in poverty alleviation and childhood development (Ministry of Gender Equality, Poverty Eradication and Social Welfare, 2021), the abrupt termination of these grants for youth when they reach 18 years of age without any transitional support has posed significant risks to their well-being. While much research in Namibia (Mnubi-Mchombu and Ocholla, 2014; Van Der Brug, 2012.) has examined the impact of OVC grants on children under the …

Exploring The Epitranscriptomic Response To Senolytics And Senomorphs In Cellular Models Of Aging, Emily Benson

Electronic Theses & Dissertations (2024 - present)

In senescence that occurs with aging, cells stop dividing and initiate a pro-inflammatory program called the senescence associated secretory phenotype (SASP). SASP can lead to cell damage and has been linked to age-related conditions such as cancer, diabetes, osteoporosis, cardiovascular disease, Alzheimer’s disease, and osteoarthritis. The epitranscriptome regulates translation through post-transcriptional RNA modifications and can control when and how much of protein synthesis occurs. Several tRNA modifications that include 5-methoxycarbonylmethyl (mcm⁵U), 5-methoxycarbonylmethyl-2-thiouridine (mcm⁵s²U), and mcm⁵Um (5-methoxycarbonylmethyl-2′-O-methyluridine) are linked to the translation of enzymes involved in the detoxification of reactive oxygen species (ROS), …

A Descriptive Analysis Of Depressive Symptoms And Body Image By Race/Ethnicity And Nativity Status Among Adolescents, Radhika Prasad

Electronic Theses & Dissertations (2024 - present)

Previous research on the immigrant health paradox among children and adolescents show a mental health advantage yet it is unclear if this applies in a similar magnitude to females (Fillion et al., 2018; Zarei et al., 2023). Immigrants may be exposed to stressors related to immigration and acculturation. Some research suggests that females respond more to stress through internalizing symptoms relative to males (Hall-Lande et al., 2007; Adkins et al., 2009). Given these gender differences in stress response, female immigrants may be particularly vulnerable to the psychological consequences of immigration related stressors. The immigrant health paradox has also overlooked subjective …

A Study Of Mercury Speciation Analysis Of Blood Using Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry For Human Biomonitoring And Clinical Applications, Emily Jean Pacer

Electronic Theses & Dissertations (2024 - present)

Mercury (Hg) exposure from environmental sources and consumer products presents a significant public health concern. The toxicity of methylmercury (MeHg) differs considerably from inorganic mercury (iHg), such that their separation and quantification in whole blood is helpful in identifying sources and possible pathways of exposure. Speciation methods provide a more detailed picture regarding human exposure to toxic mercury species and their effects on human health. This dissertation focuses on advanced analytical techniques for human biomonitoring and clinical diagnosis of Hg exposure. The primary aim of this research is to address important knowledge gaps and analytical challenges in studies of Hg …

Dishes Of Yesteryear: Memories, Stories, And Representations Of The Past Within Food Media, Diana Willis Bottomley

Electronic Theses & Dissertations (2024 - present)

In 1963, Julia Child revolutionized cooking television. Child’s The French Chef, which ran for ten years on the Boston public television station, WGBH, changed how American’s viewed, produced, and consumed food. And in the sixty years since Child’s debut, food media has grown in scope and popularity, increasingly altering how we communicate identity in and through food and foodways. In this dissertation, I examine the relation between food, media, and memory, with particular attention to: how the past moderates the connection between food and identity; how food media produce a sense of place integral to identity; and how food …

From Mitochondria To Tumor Suppression: Acat1’S Crucial Role In Gastric Cancer, Wei He, Yanfang Li, Song-Bai Liu, Ying Chang, Shiyuan Han, Xingyu Han, Zixin Ma, Hesham M Amin, Yao-Hua Song, Jin Zhou

Faculty, Staff and Student Publications

Acetyl CoA acetyltransferase 1 (ACAT1), a mitochondrial enzyme, is mainly involved in the formation and decomposition of ketones, isoleucine, and fatty acids. Previous clinical studies showed that mutations in the ACAT1 gene lead to ketoacidosis, Notably the role of ACAT1 in human cancer' pathogenesis varies depending on cancer type, and its specific role in gastric cancer remains largely unknown. In the current study, we found that the expression of ACAT1 in primary late-stage gastric cancer tumor tissues was significantly lower than in early-stage tumors. This observation was further confirmed in high-grade gastric cancer cell line MKN45. The expression of CD44 …

Childhood Obesity Interventions Need To Address Groups Experiencing Inequities, Marilyn Frenn

College of Nursing Faculty Research and Publications

No abstract provided.

Prevalence And Determinants Of Diarrhoea And Acute Respiratory Infections Among Children Aged Under Five Years In West Africa: Evidence From Demographic And Health Surveys, Derrick Nyantakyi Owusu, Henry Ofori Duah, Duah Dwomoh, Yakubu Alhassan

College of Nursing Faculty Research and Publications

Background Diarrhoea and pneumonia are the leading causes of morbidity and mortality in children aged < 5 y (under five) globally. This study sought to investigate the prevalence and determinants of diarrhoea and acute respiratory infections (ARIs) among children under five in West Africa. Methods The most recent demographic and health survey (DHS) standard for 13 West African countries was used in the study. We calculated the prevalence of diarrhoea and ARIs (2 wk prior to the survey) and performed multivariable complex logistic regression analysis to identify possible predictors of diarrhoea and ARIs. Results The weighted prevalence of diarrhoea and ARI was 13.7% and 15.9%, respectively. The prevalence of comorbid diarrhoea and ARI was 4.4%. Children aged < 2 y (p< 0.001), mothers aged < 30 y (p< 0.003), mothers without formal education (p< 0.001), poor households (p< 0.001) and poor nutritional status, wasting (p=0.005) and underweight (p< 0.001), were the independent predictors of diarrhoea. The independent predictors of ARIs were children with no childhood vaccinations (p=0.002), use of solid fuel in the household (p=0.007), being underweight (p=0.05) and diarrhoea (p< 0.001). Conclusions The findings imply the need for holistic public health interventions such as increased vaccination coverage, population-based nutritional programmes and campaigns on the use of cleaner cooking fuel targeted at high-risk subgroups in the population to reduce the burden and adverse effects of diarrhoea and ARIs in the West African region.

Perspectives From Public Health Practitioners And Advocates On Community Development For Active Living: What Are The Lasting Impacts?, Natalicio Serrano, Laurel Schmidt, Amy A Eyler, Ross C Brownson

2020-Current year OA Pubs

PURPOSE: Evidence suggests differential impacts of community development, including gentrification and displacement. Public health practitioners and advocates are key stakeholders involved in the community development process related to active living, yet little is known about their perceptions of its impacts. We explored the perspectives of relevant leaders of public health departments and key community and advocacy organizations on community development, gentrification, and displacement.

APPROACH: Purposive key informant interviews.

SETTING: CDC State Physical Activity and Nutrition (SPAN) funding recipients.

PARTICIPANTS: CDC SPAN recipient leadership (n = 10 of 16) and advocacy organizations they partnered with (n = 7 of 16).

METHOD: …

Effectively Communicating With Local Policymakers: A Randomized Trial Of Policy Brief Dissemination To Address Obesity, Elizabeth A Dodson, Renee G Parks, Rebekah R Jacob, Ruopeng An, Amy A Eyler, Nathan Lee, Alexandra B Morshed, Mary C Politi, Rachel G Tabak, Yan Yan, Ross C Brownson

2020-Current year OA Pubs

INTRODUCTION: Evidence-based policies are a powerful tool for impacting health and addressing obesity. Effectively communicating evidence to policymakers is critical to ensure evidence is incorporated into policies. While all public health is local, limited knowledge exists regarding effective approaches for improving local policymakers' uptake of evidence-based policies.

METHODS: Local policymakers were randomized to view one of four versions of a policy brief (usual care, narrative, risk-framing, and narrative/risk-framing combination). They then answered a brief survey including questions about their impressions of the brief, their likelihood of using it, and how they determine legislative priorities.

RESULTS: Responses from 331 participants indicated …

Translatability Of Findings From Cynomolgus Monkey To Human Suggests A Mechanistic Role For Il-21 In Promoting Immunogenicity To An Anti-Pd-1/Il-21 Mutein Fusion Protein, Mark A Kroenke, Ramaswamy Govindan, Et Al.

2020-Current year OA Pubs

AMG 256 is a bi-specific, heteroimmunoglobulin molecule with an anti-PD-1 antibody domain and a single IL-21 mutein domain on the C-terminus. Nonclinical studies in cynomolgus monkeys revealed that AMG 256 administration led to the development of immunogenicity-mediated responses and indicated that the IL-21 mutein domain of AMG 256 could enhance the anti-drug antibody response directed toward the monoclonal antibody domain. Anti-AMG 256 IgE were also observed in cynomolgus monkeys. A first-in-human (FIH) study in patients with advanced solid tumors was designed with these risks in mind. AMG 256 elicited ADA in 28 of 33 subjects (84.8%). However, ADA responses were …

Graceful Gait: Virtual Ballet Classes Improve Mobility And Reduce Falls More Than Wellness Classes For Older Women, Elinor C Harrison, Allison M Haussler, Lauren E Tueth, Sidney T Baudendistel, Gammon M Earhart

2020-Current year OA Pubs

INTRODUCTION: Dance is an effective and motivating form of exercise for older women, but few studies have quantified the benefits of virtual dance classes nor, specifically, ballet. This study tested the effectiveness of virtual ballet compared to virtual wellness classes, with the goal of reaching underserved populations. It is among the first to explore the effects of virtual classical ballet on functional gait mobility, balance, and quality of life measures in older women.

METHODS: Older women were recruited in two waves and randomized to two groups: a ballet class modified for older adults and a wellness-based control class. Both groups …

Using Evidence-Based Scientific Research To Influence Dietary Behavioral Change: Taking A Look In The Mirror, Clifton P. Bueno De Mesquita, Ylenia Vimercati Molano, Lara Vimercati, P. Jacob Bueno De Mesquita

Arts & Sciences Faculty Publications

Science can provide accurate information to society to inform decision-making and behavior. One contemporary topic in which the science is very clear, yet behavioral change has lagged, is climate change mitigation. Climate change scientists use evidence-based research to advocate to the public to adopt emission-reducing behaviors in various sectors such as transportation and food. However, scientists themselves often do not change their own behaviors according to the scientific consensus. We present a case study of a group of natural sciences PhD students, who, when presented with evidence and an opportunity for a behavioral change with implications for climate change mitigation, …

Adherence To Practice Parameters In Medicare Beneficiaries With Amyotrophic Lateral Sclerosis, Osvaldo J. Laurido-Soto, Irene M. Faust, Susan Searles Nielsen, Brad A. Racette

2020-Current year OA Pubs

OBJECTIVE: Physician adherence to evidence-based clinical practice parameters impacts outcomes of amyotrophic lateral sclerosis (ALS) patients. We sought to investigate compliance with the 2009 practice parameters for treatment of ALS patients in the United States, and sociodemographic and provider characteristics associated with adherence.

METHODS: In this population-based, retrospective cohort study of incident ALS patients in 2009-2014, we included all Medicare beneficiaries age ≥20 with ≥1 International Classification of Diseases, Ninth Revision, Clinical Modification ALS code (335.20) in 2009 and no prior years (N = 8,575). Variables of interest included race/ethnicity, sex, age, urban residence, Area Deprivation Index (ADI), and provider …

Uropathogenic Escherichia Coli Wield Enterobactin-Derived Catabolites As Siderophores, Zongsen Zou, John I Robinson, Lindsey K Steinberg, Jeffrey P Henderson

2020-Current year OA Pubs

Uropathogenic Escherichia coli (UPEC) secrete multiple siderophore types to scavenge extracellular iron(III) ions during clinical urinary tract infections, despite the metabolic costs of biosynthesis. Here, we find the siderophore enterobactin (Ent) and its related products to be prominent components of the iron-responsive extracellular metabolome of a model UPEC strain. Using defined Ent biosynthesis and import mutants, we identify lower molecular weight dimeric exometabolites as products of incomplete siderophore catabolism, rather than prematurely released biosynthetic intermediates. In E. coli, iron acquisition from iron(III)-Ent complexes requires intracellular esterases that hydrolyze the siderophore. Although UPEC are equipped to consume the products of completely …

Awareness And Interest In Cannabis Use For Cancer Management Among Cancer Survivors, Ikponmwosa Osaghae, Rajesh Talluri, Onyema Greg Chido-Amajuoyi, Kimberson Tanco, Dimpy P Shah, Mala Pande, Sanjay Shete

Faculty, Staff and Student Publications

BACKGROUND: We examined the awareness, interest, and information sources relating to cannabis use for cancer management (including management of cancer symptoms and treatment-related side effects) and determined factors associated with cancer survivors' awareness and interest in learning about cannabis use for cancer management.

METHODS: This was a cross-sectional study of adult cancer survivors (N = 1886) receiving treatment at a comprehensive cancer center. Weighted prevalence and multivariable logistic regression analyses were conducted.

RESULTS: Among cancer survivors, 88% were aware and 60% were interested in learning about cannabis use for cancer management. Common sources of information to learn about cannabis use …