Digital Commons Network^™

Learning From The Past: Environmental Impacts On Coral Performance, Reproduction, And Epigenetic Inheritance, Danielle M. Becker

Open Access Dissertations

Coral reef ecosystems face extreme challenges due to increasing ocean temperatures caused by anthropogenically induced global climate change and require reproductive replenishment for reef persistence. Corals and other marine invertebrates have exhibited the capacity for environmental memory, or the retention of information from prior environmental experiences, which can be inherited by subsequent generations (e.g., via non-genetic mechanisms). However, less is known about how molecular modifications in the coral epigenome influence acclimatization and adaptive responses to environmental variation within and across generations. Here, I present three manuscripts testing different mechanisms involved in coral’s physiological, reproductive, and epigenetic response to environmental perturbation …

Incomplete Streets, Michael Lewyn

Scholarly Works

Over 1700 complete streets policies have been adopted by state and local government; these policies typically provide that streets shall be designed to benefit all users, not just motorists. This article analyzes some complete streets policies, and concludes that even above-average policies are often too vague and underfunded to significantly change the status quo. The article suggests a variety of reforms that might make complete streets policies more effective.

The Neurochemistry Of Depression: The Good, The Bad And The Ugly, Kami Pearson, Kimberley Beier, Thornton Mardis, Bryan Munoz, Asma Zaidi

Faculty and Staff Publications

A large constellation of experimental evidence suggests that neuroinflammation is involved in the onset of depression and neurodegenerative disorders. Many studies have shown impairments in tryptophan metabolism, the major pathway for the synthesis of serotonin, the mood regulating neurotransmitter. This article reviews the various metabolites generated in the competing pathways of tryptophan metabolism including the kynurenine pathway. Increased synthesis of the neurotoxic compound quinolinic acid occurs at the expense of the synthesis of the neuroprotective metabolite kynurenic acid. This shift in equilibrium plays a critical role in the induction of oxidative stress, neuroinflammation, and neurotoxicity. Sufficient protein intake with adequate …

Blunt Speech Rights, Nicholas Almendares

Articles by Maurer Faculty

There is a lot to be said about the Supreme Court’s decision in 303 Creative LLC. In the wake of the decision there will be a range of commentaries like those presented in this Issue. I want to draw attention to a particular aspect of the opinion, part of a broader trend in the Court’s First Amendment jurisprudence, towards blunt, sweeping rules. By a blunt rule, I mean a simple, coarse one that lacks nuance or distinctions. Blunt rules, by their nature, tend to be sweeping: nuance, that is, distinguishing cases based on various factors, limits the scope of a …

Development Of An Order Set To Improve Consistency Of Blood Glucose Monitoring For Hospitalized Patients On Enteral Feeding, Kristen Calebaugh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Development of an Order set to Improve Consistency of Blood Glucose Monitoring for Adult Hospitalized Patients on Enteral Feeding

Kristen Calebaugh, BSN, RN

Background

Hospitalized patients often require artificial nutrition through either enteral feeding, placing the patient at risk for glucose alterations related to physiological responses of nutritional metabolism. Historically, there has been no standard of care or consistency aligning tube feedings times with point of care blood glucose testing. Without a standardized order set to guide blood glucose monitoring orders, patients on artificial nutrition may experience undetected hypo or hyperglycemia or inadequate glycemic control, which can cause adverse …

Polylactic Acid (Pla) Containing Talc Microparticles And Amorphous Polyhydroxyalkanoates (Aphas) For Improved Barrier And Mechanical Properties In Food Packaging, Mohammed Alfaifi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Polylactic acid (PLA) is a biobased and compostable polymer that is increasingly being used as an alternative to petroleum-based, non-biodegradable polymers for single-use food packaging due to its environmental benefits. It is also commercially available in large quantities, and it can be processed like polyethylene. However, it has a higher water-vapor permeability (WVP) as compared to polyolefins and polyethylene terephthalate that are the incumbent materials. This results in a competitive disadvantage in employing PLA for packaging baked goods since the shelf life of the food is likely to be reduced. In the past, barrier properties of PLA were improved by …

The Intellectual Structure Of Audit Committee Research: A Bibliometric Analysis (1969 – 2020), Joel Behrend, Marc Eulerich, David A. Wood

Faculty Publications

The audit committee is a widely recognized mechanism of effective corporate governance. We advance prior literature reviews by using bibliometric analysis techniques that comprehensively process large bodies of bibliometric information. We base inferences on citation patterns of 1,173 articles to identify concepts that “shine through” within the scientific understanding of audit committees. Using content analysis, we then analyze these concepts and explore existing interrelationships. We document a declining influence of audit committee research, as well as a widening gap between the quantitative and qualitative research camps. While the former is mostly derivative in nature, the latter produces innovative insights on …

Multidisciplinary Approach To Injury Rehabilitation: The D1 College Athlete Perspective, Lindsey Leatherman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sport injuries continue to be unavoidable disruptions in student-athletes’ athletic careers with over 200,000 injuries estimated to be reported each year in college sport (Kerr et al., 2015). Researchers continue to emphasize the importance of an interprofessional approach to rehabilitation to help athletes manage the adverse psychological and emotional reactions to injury (Appaneal et al., 2009; Gervis et al., 2020; Putukian, 2016). The purpose of this study was to extend and replicate the research of Clement and Arvinen-Barrow (2021) by incorporating perspectives of Division I US student-athletes. The current study describes 321 NCAA Division I collegiate athletes’ experiences of receiving …

Standardizing Nasogastric Tube Securement: A Quality Improvement Initiative, Shannon Lee Thompkins

Graduate Theses, Dissertations, and Problem Reports (ETD)

Problem: At a large academic medical center located in the northeastern United States, nasogastric tubes (NGT) were traditionally secured with tape. The institutional policy was nonspecific with no written procedure. The inconsistent use of nasal bridle securement devices (NBSD) and predominant use of tape has the potential to lead to a high rate of NGT dislodgement.

Background: NGT complication and dislodgement rates range from 2%-36% (Gimenes et al., 2019). Stabler et al. (2018) report 29%-63% NGT dislodgement rates in critically ill patients. Patients with intracranial hemorrhage dislodge NGTs in 25% of patients (Rahman et al., 2022)

Available Knowledge: Based on …

Iron Coated Sand: A Sustainable Substrate Amendment For Nutrient Management And Growth Of Floriculture Crops, Savannah Mead

Graduate Theses, Dissertations, and Problem Reports (ETD)

Acid mine drainage and phosphorus pollution are two of the most pervasive forms of water contamination in Appalachia and globally. The horticultural industry is a contributor to nutrient pollution via leaching from greenhouses, necessitating the adoption of more sustainable practices for container production in controlled environments. In this thesis, an acid mine drainage-based iron-coated sand product was assessed on its effectiveness for phosphate adsorption when used as a sustainable substrate amendment for soilless container production of flowering ornamentals. The first study centered around the amount of iron-coated sand to use for production of petunias, pansies, and chrysanthemums. Iron-coated sand at …

An Appalachian Perspective On Suicide: A Focus On West Virginia’S Unique Context, Erin Delaney Caswell

Graduate Theses, Dissertations, and Problem Reports (ETD)

INTRODUCTION: The Appalachian region, spanning 13 states from New York to northern Mississippi, experiences the suicide rates in the United States (U.S.), underscoring a public health crisis exacerbated by persistent socioeconomic challenges. West Virginia (WV), the only state entirely within Appalachia, serves as a focal point for understanding the broader suicide crisis in the region, as WV has the highest suicide rates in the region. Moreover, the state has several unique socioeconomic factors, like increased poverty, lower educational attainment, limited access to healthcare, and a high prevalence of chronic pain and substance that may contribute to elevated rates of suicide. …

The Role Of Uric Acid In Metabolic Abnormalities Of Obesity, Andrew P. Giromini

Graduate Theses, Dissertations, and Problem Reports (ETD)

Uric acid (UA) is the single most tightly associated metabolite for obesity and type 2 diabetes. While the field varies on whether UA is causative or correlative of the metabolic dysfunction allied to obesity, these studies use different diets and animal models to make these claims. It is the goal of this dissertation to compare different diets commonly used in this research to delve deeper into the data and determine which diets induce elevated circulating UA levels as well as which diets also induce metabolic dysfunction. Early chapters of this dissertation examine the comparison of high fructose consumption, both in …

Measures Of Feed Efficiency In Beef Cattle: Biological Basis And Effect On Response To Dietary Supplementation, Modoluwamu Idowu

Graduate Theses, Dissertations, and Problem Reports (ETD)

During the feedlot receiving period, newly weaned beef cattle face various stressors, including weaning, transportation, vaccination, and exposure to pathogens. Additionally, changes in diet and low dry matter intake contribute to nutrient deficiencies, heightening susceptibility to disease and performance declines. Therefore, we examined the effects of dietary supplementation with a multicomponent blend of prebiotics and probiotics on the health, immune status, metabolism, and performance of newly weaned beef steers during a 35-day receiving period. Our results showed that compared to the control group, the supplemental additive (SYNB) increased average daily gain (ADG), dry matter intake, and meal events during the …

Developmentally Appropriate Care In The Neonatal Intensive Care Unit (Nicu), Ashten Cenkus

Graduate Theses, Dissertations, and Problem Reports (ETD)

As specialized healthcare professionals educated in developmental care, occupational therapy practitioners (OTPs) have a role in educating, coaching, and assessing the needs of infants, their families, and the staff in the NICU. These high-risk and medically fragile infants require specialized care that considers the incorporation of neurodevelopment, neurobehavioral regulation, sensory stimulation, and motor development through supportive and appropriate interventions. A project addressing these needs across 14 weeks was implemented as part of an Occupational Therapy Doctoral (OTD) capstone experience at WVU Medicine Children’s in Morgantown, West Virginia. This project examined the results of the NICU staff's confidence, knowledge, and awareness …

Estimating Home Range Size And Density Of White-Tailed Deer (Odocoileus Virginianus) In West Virginia, Sarah M. Pesi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Big game hunting is an important source of revenue and recreation in the United States. Of big game species, white-tailed deer (Odocileus virginianus) are the most heavily pursued. White-tailed deer are a widespread generalist species, capable of existing at high densities. Hunting is often used as the primary method of managing deer populations, particularly in the eastern United States, where there is a lack of large predators. When populations reach high densities, there can be negative effects on the environment and conflicts with humans. Managers must consider both creating adequate hunting opportunities and reducing negative impacts when managing …

Development And Implementation Of Occupational Therapy Group Protocols For Individuals In Recovery For Substance Use Disorder: Considering Social Determinants Of Health And Occupational Areas Of Need, Samantha Jane Windisch

Graduate Theses, Dissertations, and Problem Reports (ETD)

Substance use disorders (SUDs) are becoming a more widespread issue globally. According to the National Survey on Drug Use and Health, 19.7 million adults in the U.S. suffered from an SUD in 2017. (SAMSHA, 2018). Recurrent alcohol and/or drug use that results in significant disability, including health issues, and/or a failure to prioritize obligations like employment, school, or family life are characteristics of SUD (SAMHSA, 2022). Research suggests that healthcare providers must integrate cutting-edge and successful treatments for this population to lower the risk of overdose and relapse rates, given the swift global spread of addictive disorders. In the past, …

Women In Extension Persevering In Leadership Roles, Lexis Danielle Trickett

Graduate Theses, Dissertations, and Problem Reports (ETD)

Over the last several decades, the rates at which women have been pursuing higher levels of education have steadily increased. However, there is a discrepancy between the number of women graduating, and the amount entering the workforce, specifically in leadership roles. The purpose of this study was to share a current profile of women in the West Virginia Cooperative Extension Service by allowing them to describe their career journeys, supports and barriers they may or may not have faced, and mentoring experiences. By using a non-experimental quantitative methodology, a population of male and female Extension Agents and Specialists were surveyed …

Empowering Inclusive Mobility: Addressing Team Challenges And Advancing Solutions For Deaf Communities In Rural West Virginia Through Innovative Engineering And Collaborative Initiatives, Morgan Elaine Bartley

Graduate Theses, Dissertations, and Problem Reports (ETD)

This report provides an overview of the strategic initiatives, challenges, and future considerations encountered by the West Virginia University (WVU) EcoCAR Team in their mission to enhance accessibility for deaf and hard-of-hearing individuals in rural West Virginia, with a specific focus on improving the Cadillac LYRIQ's features. The report delves into the stakeholder profile, encompassing demographic characteristics and mobility challenges unique to the target population, while also highlighting the team's SMART goals, key challenges faced, and forward-looking strategies to better the team.

The WVU EcoCAR Team's mission revolves around addressing mobility barriers for the deaf and hard-of-hearing community in rural …

Exploring Physical Activity Promotion And Implementation Within Inclusive Post-Secondary Education Programs: A Mixed-Methods Design, Shannon P. Zimmerman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Adults with intellectual and developmental disabilities (IDD) exhibit lower physical activity levels compared to their non-disabled counterparts, with only 23% of U.S. adults with IDD engaging in the recommended 60 minutes per day of moderate-to-vigorous physical activity. Inclusive Post-Secondary Education (IPSE) programs in the U.S. offer an opportunity to promote physical activity and address the critically low physical activity levels. Few IPSE programs have formalized physical activity courses, warranting an evaluation and development of the national curriculum in this area. This study expands on previous work by examining current physical activity promotion strategies at both the program and course levels. …

Hepatic Mrna Expression Of Innate And Adaptive Immune Genes In Beef Steers With Divergent Residual Body Weight Gain, Deborah Ologunagba

Graduate Theses, Dissertations, and Problem Reports (ETD)

Immune system function is critical to maintaining the health and increasing productivity of cattle, affecting both their growth and their disease resistance. In an efficient immune system, the liver assumes an integral function in detoxification and metabolic processes and contributes substantially to overall production and immunity. In this study, we evaluated the hepatic mRNA expression of genes involved in innate and adaptive immunity in crossbred beef steers with either a positive or negative residual body weight gain (RADG). Positive-RADG beef steers (n = 8; RADG = 0.76 kg/d) and negative-RADG beef steers (n = 8; RADG = -0.64 kg/d) were …

Infusing Machine Learning And Computational Linguistics Into Clinical Notes, Funke V. Alabi, Onyeka Omose, Omotomilola Jegede

Mathematics & Statistics Faculty Publications

Entering free-form text notes into Electronic Health Records (EHR) systems takes a lot of time from clinicians. A large portion of this paper work is viewed as a burden, which cuts into the amount of time doctors spend with patients and increases the risk of burnout. We will see how machine learning and computational linguistics can be infused in the processing of taking clinical notes. We are presenting a new language modeling task that predicts the content of notes conditioned on historical data from a patient's medical record, such as patient demographics, lab results, medications, and previous notes, with the …

Self-Efficacy And Parental Miscarried Helping In Adherence And Transition Readiness Among Adolescents And Young Adults With Epilepsy, Kirby-Estar G. Laguerre

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Given the complex regimen associated with epilepsy, ensuring that adolescents and young adults (AYAs) adhere to their medications, and are ready to transition from pediatric to adult care, is crucial to optimizing their health outcomes. Several social and ecological factors such as self-efficacy and parental miscarried helping can strengthen or weaken an adolescent’s medication adherence and readiness to shift from pediatric to adult care. Intending to contribute to informing and improving clinical care, this study sought to understand the relationships between self-efficacy, parental miscarried helping, medication adherence, and transition readiness. Methods: Using a cross-sectional observational design, 46 AYAs with …

Parental Socialization Of General And Domain-Specific Self-Control In Adolescents, Matty Johnston

Graduate Theses, Dissertations, and Problem Reports (ETD)

Adolescent self-control appears to be an important competency to develop. It has pervasive links with various outcomes (e.g., educational, financial, and interpersonal) both during adolescence and into adulthood (Allemand et al., 2019, Moffitt et al., 2011). Adolescents often report lower self-control compared to adults, although individual levels of self-control vary widely between adolescents (Allemand et al., 2019, Romer et al., 2010). Despite its importance, very little is known about how self-control develops. Thus, the current study aims to examine the relationship between parents’ self-control and that of their teen children. To further understand how adolescents' self-control may be socialized by …

Socioeconomic Status And Health Disparities Drive Differences In Accelerometer-Derived Physical Activity In Fatty Liver Disease And Significant Fibrosis, Lucia Tabacu, Sajag Swami, Mark Ledbetter, Mohamad S. Siddiqui, Ekaterina Smirnova

Mathematics & Statistics Faculty Publications

Background and aims

The cornerstone of clinical management of patients with nonalcoholic fatty liver disease (NAFLD) are lifestyle changes such as increasing physical activity (PA) aimed at improving cardiometabolic risk. To inform NAFLD prevention and treatment guidelines we aimed to: (i) quantify the role of PA on lowering the risk for NAFLD and fibrosis; (ii) characterize NAFLD and fibrosis association with PA in the context of socioeconomic environment.

Methods

A sample of 2648 participants from the NHANES 2003–2006 was selected to develop survey weighted multivariable logistic regression models for predicting NAFLD and significant fibrosis, diagnosed non-invasively via fatty liver index …

Effects Of Dietary Supplementation Of A Blend Of Saccharomyces Cerevisiae, Multiple Live Probiotic Bacteria, And Their Fermentation Products On Performance, Health, And Rumen Bacterial Community Of Newly Weaned Beef Steers During A 56-D Receiving Period, Emily Treon

Graduate Theses, Dissertations, and Problem Reports (ETD)

We examined the effects of a blend of Saccharomyces cerevisiae, multiple live probiotic bacteria and their fermentation products on performance, health, and the ruminal bacterial community of newly weaned beef steers during a 56-day receiving period. Forty newly weaned Angus crossbred steers (221 ± 25.6 kg BW; 180 ± 17 d of age) were stratified by body weight into four pens (10 steers per pen) such that each pen had a similar average body weight at the beginning of the experiment. The pens were randomly assigned to receive a corn silage basal diet (CON; n = 20) or the …

Development And Application Of Functional Immune Assays To Understand Disease In Wild Smallmouth Bass Populations, Cheyenne R. Smith

Graduate Theses, Dissertations, and Problem Reports (ETD)

Over recent decades, the scientific community has observed a disconcerting trend – a decline in the health and stability of smallmouth bass (Micropterus dolomieu) populations across the Chesapeake Bay watershed with growing economic and ecological implications. Disease, declines, and death have been observed in multiple locations, particularly in the Susquehanna and Potomac drainages with the adults disproportionately affected in the Potomac River basin and young-of-year in the Susquehanna River basin. There has not been a single or consistent cause to the declines or mortality events. More likely, it is believed immunosuppression relating to a complex mixture of stressors has been …

Leds For Controlled Environment Agriculture: Leveraging Light To Optimize Crops, Tristan D. Sanders

Graduate Theses, Dissertations, and Problem Reports (ETD)

Indoor agriculture is a growing industry with many of its benefits being recognized. Light emitting diodes (LEDs) reduce production costs compared to traditional light sources. LEDs emit narrow bandwidths of light that allow growers to easily change the wavelengths plants are being grown under by using different combinations of wavelengths. Manipulating the light that plants are grown under is a method to change their physiology which is the basis of this thesis. The goal of the first two studies was to investigate how different light spectra can be used to enhance the nutrition content, growth, and morphology of kale and …

Associations Between Diabetes-Specific Psychological Flexibility, Family Conflict, Parental Distress And Adherence In Adolescents With Type 1 Diabetes, Rebecca I. Laquaglia

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Type 1 diabetes (T1D) is a chronic disease that impacts the lives of millions of children and adolescents in the United States. Adherence to diabetes medical regimens is often challenging, particularly among adolescents. Based on previous research, diabetes-specific psychological flexibility, or the ability of an individual with T1D to psychologically adjust to, accept, and commit action to manage their diagnosis, may improve adherence in youth with T1D. Factors such as diabetes-specific family conflict (i.e., conflict within parent-child dyads that is specifically related to T1D management) and diabetes-specific parental distress (i.e., emotional distress experienced by a parent or caregiver as …

Assessing The Impact Of Olive Oil And Flaxseed Oil Supplementation On Hypertension And Inflammation In Healthy And At-Risk Adults, Tara Bess Mcnabb

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Supplementation of olive oil and flaxseed oil and their impacts on hypertension and inflammation have been reported for healthy and hypertensive adults. However, a comprehensive systematic literature review and meta-analysis on the preventive benefit of plant oil supplementation in healthy adults and adults at risk of inflammation inducing hypertension is lacking.

Objective: to evaluate human clinical trials assessing the impact of olive oil and flaxseed oil capsules on systolic blood pressure (SBP) and diastolic blood pressure (DBP) and select inflammatory markers in non-hypertensive and at-risk adults of hypertension.

Data sources: Four databases were searched in October 2023 …

Immune Outcomes Affected By Selection For Parasite Resistance In Katahdin Sheep, Kelsey Lynne Bentley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Our understanding of the complex connection between selection for parasite resistance and the overall health outcomes in livestock is unclear. This study investigates the impact of post-weaning fecal egg count (PFEC) estimated breeding values (EBV) on health outcomes and immune responses in Katahdin sheep. Selection for PFEC, favoring Low-PFEC lambs, not only affects survivability to weaning but also suggests broader implications for immunity beyond parasite resistance. The effect of PFEC EBV on antibody production in response to vaccination against Clostridium perfringens type C&D and tetanus toxoid (CD&T) revealed a stepwise decrease in immunoglobin (IgG) from Low-PFEC to High-PFEC groups upon …