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Chitin-Enriched Insect Frass Fertilizer As A Biorational Alternative For Root-Knot Nematode (Meloidogyne Incognita) Management, James Kisaakye, Dennis Beesigamukama, Solveig Haukeland, Sevgan Subramanian, Paul K. Thiongo, Segenet Kelemu, Chrysantus M. Tanga Jan 2024

Chitin-Enriched Insect Frass Fertilizer As A Biorational Alternative For Root-Knot Nematode (Meloidogyne Incognita) Management, James Kisaakye, Dennis Beesigamukama, Solveig Haukeland, Sevgan Subramanian, Paul K. Thiongo, Segenet Kelemu, Chrysantus M. Tanga

All Peer-Reviewed Publications

Root-knot nematodes (Meloidogyne spp.) are serious pests of most food crops, causing up to 100% yield loss. Nevertheless, commercial nematicides are costly and harmful to the environment. While the nematicidal potential of crustacean and synthetic chitin has been demonstrated globally, research on the potential of insect-derived chitin for nematode control has received limited attention. Here, seven chitin-fortified black soldier fly frass fertilizer extracts (chFE) were assessed for their suppressiveness of Meloidogyne incognita and impacts on spinach growth in comparison with a commercial nematicide using in vitro and in vivo bioassays. The performance of chFE and control treatments was assessed by …


Outcomes Of The Leap Feasibility Trial—A Low-Threshold, Exercise Programme With Protein Supplementation To Target Frailty And Poor Physical Functioning In People Experiencing Homelessness And Addiction Issues, Fiona Kennedy, Clíona Ní Cheallaigh, Roman Romero-Ortuno, Suzanne L. Doyle, Julie Broderick Jan 2024

Outcomes Of The Leap Feasibility Trial—A Low-Threshold, Exercise Programme With Protein Supplementation To Target Frailty And Poor Physical Functioning In People Experiencing Homelessness And Addiction Issues, Fiona Kennedy, Clíona Ní Cheallaigh, Roman Romero-Ortuno, Suzanne L. Doyle, Julie Broderick

Articles

Background People experiencing homelessness are more likely to experience poor health with physical functioning deficits and frailty commonly reported. It is not well known how strategies to target physical functioning deficits and frailty work in practice in this group. The primary aim of this study was to explore the feasibility of an exercise intervention with protein supplementation to target physical functioning and frailty in people experiencing homelessness evaluated by recruitment and retention rates, adherence to the exercise sessions and protein supplement, adverse effects, programme feedback and characteristics of non-returners, sporadic and frequent attenders. The secondary aim was to evaluate changes …


Gvsu Undergraduate And Graduate Catalog, 2024-2025, Grand Valley State University Jan 2024

Gvsu Undergraduate And Graduate Catalog, 2024-2025, Grand Valley State University

Course Catalogs, 1963 - Current

Grand Valley State University 2024-2025 undergraduate and graduate course catalog. Course catalogs are published annually to provide students with information and guidance for enrollment.


America's Next "Stop Model!": Model Deletion, Jevan Hutson, Ben Winters Jan 2024

America's Next "Stop Model!": Model Deletion, Jevan Hutson, Ben Winters

Articles

This Essay explores the emergence of model deletion- the compelled destruction or dispossession of certain data, algorithms, models, and associated work products created or shaped by illegal means- as a remedy, right, and requirement for harmful applications of Al and ML systems. Part I examines model deletion's emergence as a consumer protection remedy and its conception as a positive right and regulatory requirement. Part II considers the constellation of federal and state actors, such as federal and state enforcement agencies and legislative bodies, who might seek model deletion to address particular Al and ML harms. Part III underscores the need …


Tigra Scientifica, Full Issue Jan 2024

Tigra Scientifica, Full Issue

Tigra scientifica

Tigra scientifica, showcasing the outstanding work by Clemson University students in the Creative Inquiry course Popular Science Journalism. Science and technology shape our world in profound ways — from the rise of space tourism to the rapid development of new medical treatments. In a democracy, communicating science is essential for informed debate and decision-making, a responsibility these students have embraced with energy and skill. The magazine began in Spring 2011 under Holly Tuten, Ph.D., who founded the CI course to pass along her passion for science writing. Since then, more than 200 students from 14 majors across five colleges have …


Effect Of Nanocapsules And Extract Of Metarhizium Anisopliae In Inhibiting Acetylcholine Esterase Enzyme In Musca Domestica Larvae., Aliaa Abdul Aziz Hammed, Hazim Idan Al Shammari, Soolaf A Kathiar Jan 2024

Effect Of Nanocapsules And Extract Of Metarhizium Anisopliae In Inhibiting Acetylcholine Esterase Enzyme In Musca Domestica Larvae., Aliaa Abdul Aziz Hammed, Hazim Idan Al Shammari, Soolaf A Kathiar

Baghdad Science Journal

M. domestica is the most important insect that transmit pathogens for diseases in the world. The use of nanotechnology is eco-friendly method in control pests. The study aims to investigate the feasibility of bio-manufacturing nanocapsules of fungal secondary metabolites in order to improve the efficiency of metabolite and assess their inhibitory effect on the acetylcholine esterase enzyme in housefly larvae. An equal mixture of organic solvents, ethyl acetate and dichloromethane, was used to extract the metabolic products of the fungus M. anisopliae, (PEG4000) and chitosan was used in the preparation of nanocapsules. The results of the DLS granular size assay …


An Integrative Study On Wood-Boring Beetle Larvae: Nutritional Properties, Gut Microbiota And Isolation Of Bioactive Compounds, Shadrack Kibet Jan 2024

An Integrative Study On Wood-Boring Beetle Larvae: Nutritional Properties, Gut Microbiota And Isolation Of Bioactive Compounds, Shadrack Kibet

All Master’s Theses

Edible insects are increasingly recognized as a solution to several problems faced by mankind, including hunger, malnutrition and microbial infections. Additionally, the gut symbionts of insects, along with their associated metabolites and enzymes, hold promising potential for industrial and pharmaceutical applications. However, the detailed nutritional properties, gut microbiota, and microbial secondary metabolites associated with the gut symbionts of various insects, including wood-boring beetles, have not yet been comprehensively reported. In this current study, the nutritional properties, and the characteristics of the gut microbiota of two wood-boring species (Titocerus jaspideus and Passalus punctiger) collected from two indigenous forested areas was investigated. …


Physicochemical Characterization Of Edible Insect Oils: Insights Into Fatty Acid Composition, Thermal Behavior And Quality Parameters, Eng-Tong Phuah, Yee-Ying Lee, Teck-Kim Tang, Guanghui Li, Shyang-Pei Hong, Syazana Abdullah Lim Jan 2024

Physicochemical Characterization Of Edible Insect Oils: Insights Into Fatty Acid Composition, Thermal Behavior And Quality Parameters, Eng-Tong Phuah, Yee-Ying Lee, Teck-Kim Tang, Guanghui Li, Shyang-Pei Hong, Syazana Abdullah Lim

ASEAN Journal on Science and Technology for Development

Edible insects are emerging as a sustainable food source due to their high nutritional value. This study employed the three-phase partitioning (TPP) method to extract oils from sago worm (Rhynchophorus ferrugineus), superworm (Zophobas morio), and cricket (Acheta domesticus). The study evaluated and compared the physicochemical properties of these insect oils, including iodine value (IV), peroxide value (PV), p-anisidine value (p-AV), acid value (AV), refractive index (RI), thermal behavior, and fatty acid compositions. Results revealed that the sago worm exhibited the highest oil yield (47.8 ± 2.2%) compared to the superworm (23.8 ± 1.4%) and cricket (6.4 ± 0.6%). Cricket oil …


The Effect Of Biochar From Plant Materials On Agricultural Acid Sulfate Soil: A Laboratory Incubation, Syazwan Sulaiman, Namasivayam Navaranjan, Guillermo Hernandez-Ramirez, Zohrah Sulaiman, Kathereen Liew Jan 2024

The Effect Of Biochar From Plant Materials On Agricultural Acid Sulfate Soil: A Laboratory Incubation, Syazwan Sulaiman, Namasivayam Navaranjan, Guillermo Hernandez-Ramirez, Zohrah Sulaiman, Kathereen Liew

ASEAN Journal on Science and Technology for Development

The scarcity of suitable arable land has led to the development of acid sulfate soil for cultivation. The major problems of acid sulfate soil are the inherent low pH and available phosphorus (P) as well as the mobilization of toxic elements such as aluminium (Al) and iron (Fe), rendering the soil unfavourable for crop production. The present work aimed to evaluate the effect of biochar from plant materials on the selected parameters of acid sulfate soil in a laboratory incubation, with unamended control and dolomite treatment soils for comparison. The application of biochar significantly increased (P < 0.05) soil pH by 0.4-0.6 units as well as the soil available P by 13.1 mg kg-1 relative to the control. The soil exchangeable Al was significantly reduced (by 2.4 cmol kg-1 when compared with the control treatment. The dolomite treatment was superior relative to biochar application in increasing soil pH and decreasing Al. The dolomite application, however, was inferior to biochar treatment in increasing soil available P. Moreover, no favourable change was observed in available Fe with the applications of either biochar or lime. These results indicated that biochar has the potential for the amelioration of acid sulfate soil, especially in increasing available P. Further studies should explore the effectiveness of biochar and lime co-application in altering a wider range of soil chemical parameters to inform management options of acid sulfate soil for cultivation.


Assessing The Organic Acids-Solubilized Collagen Derived From The Skin Of Unicornfish (Naso Reticulatus Randall, 2011) On Physicochemical And Structural Characteristics: Toward Alternative Source For Industrial Applications, Dayang Fazrianie Harianto, Abdul Aziz Jaziri, Rossita Shapawi, Ruzaidi Azli Mohd Mokhtar, Wan Norhana Md. Noordin, Masmunira Rambli, Nurul Huda Jan 2024

Assessing The Organic Acids-Solubilized Collagen Derived From The Skin Of Unicornfish (Naso Reticulatus Randall, 2011) On Physicochemical And Structural Characteristics: Toward Alternative Source For Industrial Applications, Dayang Fazrianie Harianto, Abdul Aziz Jaziri, Rossita Shapawi, Ruzaidi Azli Mohd Mokhtar, Wan Norhana Md. Noordin, Masmunira Rambli, Nurul Huda

ASEAN Journal on Science and Technology for Development

Converting skin by-product of unicornfish (Naso reticulatus Randall, 2011) into a valuable commodity like collagen is a good strategy to explore alternative sources for land-based animals. Additionally, marine fish collagens are preferable due to their safer and great properties. This project aimed to compare extractability of collagens prepared with three organic acids (i.e., acetic, lactic and citric acids), and their characteristics were also discussed. Collagen extracted with citric acid (CSCUS) (7.10%) had a significantly higher yield (p


Assessment Of Novel Plant-Based Fat Efficiency In Comminuted Chicken Meat System, Salma Mohamad Yusop, Shu Jo Lin, Nurkhuzaiah Kamaruzaman, Nurlisa Mohd Azhari Jan 2024

Assessment Of Novel Plant-Based Fat Efficiency In Comminuted Chicken Meat System, Salma Mohamad Yusop, Shu Jo Lin, Nurkhuzaiah Kamaruzaman, Nurlisa Mohd Azhari

ASEAN Journal on Science and Technology for Development

The composition of fats and oils significantly impacts the flavour, nutrition, and appearance of food. Excessive consumption of saturated fatty acids, primarily found in animal fats, raises the risk of coronary heart disease. To address this, plant-based fats are used as substitutes, with microalgae offering unique nutritional benefits as a fat source. This study evaluates the performance of structured plant-based fats, incorporating microalgae (Aurantiochytrium sp. SW1), as a fat substitute in chicken patties. Four formulations were tested: 0% (control), 5%, 7%, and 10% structured microalgae-based fat. Colour, texture, water-holding capacity, cooking loss, and microstructure in both raw and cooked samples …


Non-Invasive Digital Refractometer To Measure Maturation Of Climacteric Fruits, Jhoorhanah A. Halim, Denni Kurniawan, Dina S. Laila, Allysa Norjemee, Nuur A. L. Nesseruddin, Asrarul A. Noraidi, Beston F. Nore Jan 2024

Non-Invasive Digital Refractometer To Measure Maturation Of Climacteric Fruits, Jhoorhanah A. Halim, Denni Kurniawan, Dina S. Laila, Allysa Norjemee, Nuur A. L. Nesseruddin, Asrarul A. Noraidi, Beston F. Nore

ASEAN Journal on Science and Technology for Development

Sugar content is a superior quality indicator for the post-harvesting and ripening status of climacteric fruits. Total soluble solids (TSS) represented by °Brix index is a measure of the sugar content. The conventional way to measure TSS is by invasive (IN) technique using manual or digital refractometers. While non-invasive (NIN) infrared refractometer devices have been developed in recent years for various agricultural and food science applications, its accuracy to measure fruit TSS directly is not straightforward, as the device is only dedicated to uses for a specific fruit. This study aims to investigate the suitability of the use of a …


Development Of Halalan Tayyiban Plant-Based Cheese Formulations, Hasna B. Mazalana, Mas M. Rambli, Syazana A. Lim, Beston F. Nore Jan 2024

Development Of Halalan Tayyiban Plant-Based Cheese Formulations, Hasna B. Mazalana, Mas M. Rambli, Syazana A. Lim, Beston F. Nore

ASEAN Journal on Science and Technology for Development

The worldwide cheese production is dominated by animal milk sources with various industrial procedures, including animal rennet. There is a need to diversify the animal-based dairy products into plant-based one, not only to nurture the halalan tayyiban concept for Muslims, but also to accommodate the dietary restriction of some consumers. The objective of this work is to formulate a cheese type derived from plant-based milk with permissible ingredients to create a product for Muslim and non-Muslim consumers. In this study, we explored the use of conventional and non-conventional cheese-making procedures. A total of four experimental formulations (EF1-4) combinations were conducted …


Unveiling The Antioxidant Properties Of Stenochlaena Palustris And Diplazium Esculentum Through Time-Dependent Analysis, Nurnajiihah A. Samad, Hasna B. Mazalan, Hazimah Sharifulazar, Aida M. Basri, Masayoshi Arai Jan 2024

Unveiling The Antioxidant Properties Of Stenochlaena Palustris And Diplazium Esculentum Through Time-Dependent Analysis, Nurnajiihah A. Samad, Hasna B. Mazalan, Hazimah Sharifulazar, Aida M. Basri, Masayoshi Arai

ASEAN Journal on Science and Technology for Development

Medicinal plants are generally known for its health benefits and there has been ongoing research to gather evidence on potential plants that could exhibit antioxidant activities. In this study, we explored underutilised local medicinal plants which are Stenochlaena palustris and Diplazium esculentum, locally known as ‘Lemiding’ and ‘Pakis’, respectively. The aim was to determine the effect of extraction time on phytochemical contents, antioxidant activities and total phenolic content (TPC) of the two plant species. Maceration method was used to extract the compounds from leaves of the plant in distilled water at different durations of extraction i.e. 2 hours, 4 hours, …


Innovative Approaches And Challenges In Brunei's Agricultural Management, Nuramalina Manshor, Ulaganathan Subramanian Jan 2024

Innovative Approaches And Challenges In Brunei's Agricultural Management, Nuramalina Manshor, Ulaganathan Subramanian

ASEAN Journal on Science and Technology for Development

The management and development in agriculture attract agricultural economic science for the pricing, business, farm policy, and financial knowledge. It conjointly draws on plant and animal sciences for soil, seed and fertilizer information, weed control, insect management, and rationing and breeding; agricultural engineering knowledge for farmhouses, vehicles, irrigation, field drying, drainage, and management of erosions; and data on human behavior in Science and Social Science.


Optimization Of Ultrasound-Assisted Anthocyanin Extraction From Agricultural Waste Purple Corn Silk For Multifunctional Hemp Finishes, Benjamas Klaykruayat, Nattaya Vuthiganond, Pisutsaran Chitichotpanya Jan 2024

Optimization Of Ultrasound-Assisted Anthocyanin Extraction From Agricultural Waste Purple Corn Silk For Multifunctional Hemp Finishes, Benjamas Klaykruayat, Nattaya Vuthiganond, Pisutsaran Chitichotpanya

Journal of Metals, Materials and Minerals

The utilization of agricultural wastes for textile dyeing has gained popularity due to their safe and environmentally friendly properties, as well as the resource sustainability. Natural dye extraction is usually achieved through solvent extraction, which is time-consuming, requires a lot of solvent, and degrades desired compounds at high temperatures. Thus, this study investigated ultrasound-assisted anthocyanin extraction from agricultural waste purple corn silk as natural functional colorants for hemp finishes, given the numerous health benefits associated with anthocyanin. In order to optimize the extraction processes and evaluate the synergistic impact of these conditions, response surface methodology was implemented. The optimum conditions …


Photoluminescent Carbon Nanodots For Artificial Photosynthesis, Rajie A. Medina, Michael E. Franco, Lyn Marie De Juan-Corpuz, Ryan D. Corpuz Jan 2024

Photoluminescent Carbon Nanodots For Artificial Photosynthesis, Rajie A. Medina, Michael E. Franco, Lyn Marie De Juan-Corpuz, Ryan D. Corpuz

Journal of Metals, Materials and Minerals

The emerging field of carbon dots (CDs), a type of carbon nanostructure that has gained significant attention due to its unique properties and potential applications. CDs possess remarkable attributes, including photoluminescence, electrochemical potential, compatibility with living organisms, solubility in water, chemical stability, and versatile surface properties. The chemical structure, particle size, and surface functionalities of CDs all have an impact on their photoluminescent properties, which are the focus of this review. The photoluminescence mechanism in CDs is discussed, highlighting their amorphous structure, and comparing them to graphene quantum dots. The paper delves into the application of CDs in artificial photosynthesis, …


Institute For Global Health And Development : Annual 2024, Institute For Global Health And Development Jan 2024

Institute For Global Health And Development : Annual 2024, Institute For Global Health And Development

IGHD Newsletters

  • Message From The Director
  • Workshops & Conferences
  • Climate Change, Agriculture, Human Nutrition & Development in Pakistan
  • What Works Climate Solutions Summit, Berlin
  • IGNIT3 Consultative Workshop on Nutrition for Health Professionals
  • Climate Change and Health Symposium
  • Collaborating For Change
  • IGHD Hosts Workshop on Research Concepts & Basic Methodology
  • SDSN Pakistan Leadership Council Meeting – 2024
  • AKDN Technical Working Group (TWG) Meeting 2024
  • Projects In the Spotlight
  • Shining Light On Achievement
  • Education And Capacity Building
  • Team Building Activities
  • Research Insights


Nsu Florida Undergraduate Student Catalog 2024-2025, Nova Southeastern University Jan 2024

Nsu Florida Undergraduate Student Catalog 2024-2025, Nova Southeastern University

Undergraduate Programs Course Catalogs

No abstract provided.


Effect Of Frying On Physicochemical And Nutritional Qualities Of Herbs And Spices Incorporated Rice Cracker, Simran Sharma, Ritesh Sharma, S. Chakkaravarthi, Saravanan Mani, Ankur Kumar, Shruti Mishra, R. Sasikumar, Amit K. Jaiswal Jan 2024

Effect Of Frying On Physicochemical And Nutritional Qualities Of Herbs And Spices Incorporated Rice Cracker, Simran Sharma, Ritesh Sharma, S. Chakkaravarthi, Saravanan Mani, Ankur Kumar, Shruti Mishra, R. Sasikumar, Amit K. Jaiswal

Articles

Herbs and spices are rich in bioactive compounds that are known to impart health benefits. Incorporation of these herbs/spices in snacks might also enhance the nutritional quality of the products. This study aimed to examine the potential nutritional benefits and loss associated with the frying of herb/spice rice crackers. Four different varieties of rice-based crackers incorporated individually with mint, green chili, red chili, and cumin were evaluated by different parameters before and after frying. The raw rice cracker incorporated with herb/spice exhibited significantly higher protein (4.19 to 5.30 %), fiber (1.78 to 1.97 %), mineral, pigment (chlorophyl 0.4 to 0.7 …


Anti-Listeria Of H2o2-Peroxyacetic Acid Anti-Listeria Efficacy Of A Hydrogen Peroxide-Peroxyacetic Acid Mixer In Bacterial Buffered Solution And On Bell Peppers, Peighton Denae Foster Jan 2024

Anti-Listeria Of H2o2-Peroxyacetic Acid Anti-Listeria Efficacy Of A Hydrogen Peroxide-Peroxyacetic Acid Mixer In Bacterial Buffered Solution And On Bell Peppers, Peighton Denae Foster

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study aims to 1) evaluate the efficacy of H2O2-peroxyacetic acid (PAA) mixer to inactivate Listeria monocytogenes in 0.1% buffered-peptone-water; 2) evaluate the reduction and mitigation of cross-contamination on peppers. For the study-1, aliquots of 1.0-ml mixer solutions (0.25, 0.50 and 0.84%) were added to the first 3-well of 8-strip-deep-well microplates. Then, the 0.1 ml of 10-fold dilution the Nalidixic-acid-resistant (NaL) L. monocytogenes was added and mixed immediately with a multichannel pipette. After exposure for 0, 5, 15, 30, and up to 120-s, 1 ml of 2×D/E neutralized solution was added to terminate the reaction followed …


Electronic Symptom Management Using Pros In A Rural, Appalachian Medical Oncologic Population, Andrea Ray Bailey Jan 2024

Electronic Symptom Management Using Pros In A Rural, Appalachian Medical Oncologic Population, Andrea Ray Bailey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Systemic chemotherapy is a cornerstone of cancer treatment, but it often leads to significant side effects, which may impact patients' quality of life and lead to increased acute healthcare utilization. Although patients are typically informed of potential symptoms and advised to seek care as needed, many struggle to understand and manage symptoms effectively. Patient-reported outcomes (PROs) have been shown to improve symptom monitoring, decrease symptom burden, and reduce emergency department visits and hospital admissions. Electronic patient-reported outcomes (ePROs), in particular, offer timely and accessible symptom tracking, though their effectiveness has largely been evaluated within urban clinical trial settings and …


Longevity In Afrikaner Cattle: A Survival Analysis, Allison M. Bot Steffl Jan 2024

Longevity In Afrikaner Cattle: A Survival Analysis, Allison M. Bot Steffl

Electronic Theses and Dissertations

The Afrikaner breed of cattle is indigenous to South Africa and due to their hardiness was once the most popular breed amongst farmers. The objectives for this study were to: (1) estimate environmental effects (age at first calving, season) and (2) genetic variance affecting longevity in Afrikaner cattle using survival analysis and a Weibull model and (3) evaluate the effect of the Infusion Project on longevity utilizing a Cox model. For the first objective, age at first calving impacted longevity as younger age at first calving was associated with decreased longevity. Season of birth and year of birth also impacted …


Hepatic Failure And Hyperbilirubinemia Secondary To Hemolytic Disease Of The Newborn, Matthew Reinhardt, Marya L Strand, Dajana Sabic Jan 2024

Hepatic Failure And Hyperbilirubinemia Secondary To Hemolytic Disease Of The Newborn, Matthew Reinhardt, Marya L Strand, Dajana Sabic

Faculty, Staff and Students Publications

Anti-D antibody is the most common cause of hemolytic disease of the newborn (HDN). Other antigens have emerged, causing significant damage to the newborn. We report a case of a 31-week dichorionic diamniotic twin born emergently to a mother with anti-C and anti-D antibodies who required multiple percutaneous umbilical cord blood sampling (PUBS) and transfusions. Extensive resuscitation at birth was required due to severe anemia, hypovolemia, and prematurity. Ensuing liver damage occurred with subsequent profound coagulopathy, transaminitis, and direct hyperbilirubinemia that required significant support. This patient developed several unique findings including the inability to monitor oxygen saturations due to dermal …


Mecp2-Related Disorders While Gene-Based Therapies Are On The Horizon, Katherine Allison, Mirjana Maletic-Savatic, Davut Pehlivan Jan 2024

Mecp2-Related Disorders While Gene-Based Therapies Are On The Horizon, Katherine Allison, Mirjana Maletic-Savatic, Davut Pehlivan

Faculty, Staff and Students Publications

The emergence of new genetic tools has led to the discovery of the genetic bases of many intellectual and developmental disabilities. This creates exciting opportunities for research and treatment development, and a few genetic disorders (e.g., spinal muscular atrophy) have recently been treated with gene-based therapies. MECP2 is found on the X chromosome and regulates the transcription of thousands of genes. Loss of MECP2 gene product leads to Rett Syndrome, a disease found primarily in females, and is characterized by developmental regression, motor dysfunction, midline hand stereotypies, autonomic nervous system dysfunction, epilepsy, scoliosis, and autistic-like behavior. Duplication of MECP2 causes …


Polygenic Scores And Mendelian Randomization Identify Plasma Proteins Causally Implicated In Alzheimer’S Disease, Davis B Cammann, Yimei Lu, Jerome I Rotter, Alexis C Wood, Jingchun Chen Jan 2024

Polygenic Scores And Mendelian Randomization Identify Plasma Proteins Causally Implicated In Alzheimer’S Disease, Davis B Cammann, Yimei Lu, Jerome I Rotter, Alexis C Wood, Jingchun Chen

Faculty, Staff and Students Publications

BACKGROUND: An increasing body of evidence suggests that neuroinflammation is one of the key drivers of late-onset Alzheimer's disease (LOAD) pathology. Due to the increased permeability of the blood-brain barrier (BBB) in older adults, peripheral plasma proteins can infiltrate the central nervous system (CNS) and drive neuroinflammation through interactions with neurons and glial cells. Because these inflammatory factors are heritable, a greater understanding of their genetic relationship with LOAD could identify new biomarkers that contribute to LOAD pathology or offer protection against it.

METHODS: We used a genome-wide association study (GWAS) of 90 different plasma proteins (

RESULTS: We identified …


Effects Of Blood Flow Restriction Resistance Training On Autonomic And Endothelial Function In Persons With Parkinson's Disease, Annie Bane, Lorraine Wilson, Jill Jumper, Lindsay Spindler, Pricilla Wyatt, Darryn Willoughby Jan 2024

Effects Of Blood Flow Restriction Resistance Training On Autonomic And Endothelial Function In Persons With Parkinson's Disease, Annie Bane, Lorraine Wilson, Jill Jumper, Lindsay Spindler, Pricilla Wyatt, Darryn Willoughby

Faculty, Staff and Students Publications

Background: Autonomic dysfunction precedes endothelial dysfunction in Parkinson's disease (PD) and causes blood pressure and circulation abnormalities that are highly disruptive to one's quality of life. While exercise interventions have proven helpful for motor symptoms of PD, improving associated non-motor symptoms is limited. Low-intensity resistance training with blood flow restriction (LIRT-BFR) improves autonomic dysfunction in non-PD patients and high-intensity resistance training (HIRT) is recommended for motor symptom improvements for people with PD (PwPD).

Objective: To determine the effects of LIRT-BFR and HIRT on homocysteine and autonomic and endothelial function in PwPD and to determine the hemodynamic loads during LIRT-BFR and …


Liver Directed Adeno-Associated Viral Vectors To Treat Metabolic Disease, Marcel A Chuecos, William R Lagor Jan 2024

Liver Directed Adeno-Associated Viral Vectors To Treat Metabolic Disease, Marcel A Chuecos, William R Lagor

Faculty, Staff and Students Publications

The liver is the metabolic center of the body and an ideal target for gene therapy of inherited metabolic disorders (IMDs). Adeno-associated viral (AAV) vectors can deliver transgenes to the liver with high efficiency and specificity and a favorable safety profile. Recombinant AAV vectors contain only the transgene cassette, and their payload is converted to non-integrating circular double-stranded DNA episomes, which can provide stable expression from months to years. Insights from cellular studies and preclinical animal models have provided valuable information about AAV capsid serotypes with a high liver tropism. These vectors have been applied successfully in the clinic, particularly …


Fluoxetine And Sertraline Inhibit Height Growth And Growth Hormone Signaling During Puberty, Chadi Calarge, Chima Amushie, Stephanie Dinh, James A Mills, Sridevi Devaraj, Griselda Barba-Villalobos, Jacqueline Nguyen, Jose M Garcia, Stephanie Sisley, Fida Bacha, Babette Zemel Jan 2024

Fluoxetine And Sertraline Inhibit Height Growth And Growth Hormone Signaling During Puberty, Chadi Calarge, Chima Amushie, Stephanie Dinh, James A Mills, Sridevi Devaraj, Griselda Barba-Villalobos, Jacqueline Nguyen, Jose M Garcia, Stephanie Sisley, Fida Bacha, Babette Zemel

Faculty, Staff and Students Publications

Purpose: The aim of this study was to examine the effect of fluoxetine and sertraline on height growth and insulin-like growth factor-1 (IGF-1) during puberty.

Methods: In this 6-month cohort study, electronic medical records were used to identify 8- to 15-year-old participants, within 1 month of starting fluoxetine (n = 39) or sertraline (n = 27), and sexual maturation stages 2 to 4 were confirmed. Conditions that interfere with height growth led to exclusion. Participants underwent anthropometric assessments and phlebotomy. Healthy, unmedicated children (n = 36) also provided anthropometric data.

Results: After the baseline height Z-score, sex, Tanner stage, daily …


Desert Or Mirage? An Examination Of Food Deserts In Iowa Cities, Andrew Creasey Jan 2024

Desert Or Mirage? An Examination Of Food Deserts In Iowa Cities, Andrew Creasey

Graduate Research Papers

Food insecurity affects millions of Americans and has been widely recognized as a significant health and economic issue. Because of this, researchers have sought to develop ways to identify areas that are prone to food insecurity, which have become known as food deserts. Food deserts have been broadly defined through a confluence of three factors: low income, a lack of vehicle access, and a predetermined distance from a healthy food retailer. But research into food deserts in Iowa is limited, and the most prominent source of information on this topic, the Food Access Research Atlas created by the U.S. Department …