Digital Commons Network^™

Management Of Infliximab Refractory Immune Checkpoint Inhibitor Gastrointestinal Toxicity: A Multicenter Case Series, Catriona Harvey, Kazi J Nahar, Janet Mckeown, Serigne N Lo, Sheima Farag, Nadia Yousaf, Kate Young, Liselotte Tas, Aafke Meerveld-Eggink, Christian Blank, Austin Thomas, Jennifer Mcquade, Bastian Schilling, Douglas B Johnson, Roberto Martín Huertas, Ana Arance, Joanna Lee, Lisa Zimmer, Georgina V Long, Matteo S Carlino, Yinghong Wang, Alexander Maxwell Menzies

Faculty, Staff and Student Publications

Background: Immune checkpoint inhibitor (ICI) gastrointestinal toxicity (gastritis, enteritis, colitis) is a major cause of morbidity and treatment-related death. Guidelines agree steroid-refractory cases warrant infliximab, however best management of infliximab-refractory ICI gastrointestinal toxicity (IRIGItox) is unknown.

Methods: We conducted an international multicenter retrospective case series. IRIGItox was defined as failure of symptom resolution ≤grade 1 (Common Terminology Criteria for Adverse Events V.5.0) following ≥2 infliximab doses or failure of symptom resolution ≤grade 2 after one dose. Data were extracted regarding demographics, steroid use, response to treatment, and survival outcomes. Toxicity was graded at symptom onset and time of infliximab failure. …

The Effects Of Loneliness And Suicidal Ideation On U.S. Veterans, Sean Donnelly

Walden Dissertations and Doctoral Studies

No abstract provided.

A Case Of Occlusive Myocardial Infarction Caused By Nephrotic Syndrome In A 26-Year-Old Type 1 Diabetic, Kyle Admire, Charlotta Jornlid, Chelsea Ryan, Rebecca Pauly

Marshall Journal of Medicine

Nephrotic syndrome is a rare condition distinguished by proteinuria exceeding 3g per day. Other associated characteristics include hematuria, hypoalbuminemia, edema, and hyperlipidemia. There is an array of complications of this syndrome, which are primarily due to the profound losses of protein in the urine. One such complication is thromboembolism, with most documented cases in the form of venous thromboembolism of the extremities which is in part due to urinary loss of antithrombin III and increased synthesis of prothrombotic factors. There are limited available data regarding arterial thrombi and especially few reports about coronary thromboses, which can be life-threatening. In this …

Ultrasound – An Underutilized Diagnostic Tool For Ventricular Assist Device Driveline Infections, Kristina Krzelj, Tomislav Tokic, Tomislav Kopjar, Maja Cikes, Davor Milicic, Hrvoje Gasparovic

The VAD Journal

Patients with ventricular assist device (VAD) driveline infections (DLI) have reduced quality of life and increased risk of severe complications, such as sepsis, hemorrhagic or ischemic stroke, and wound infections. The management of VAD patients imposes a significant financial burden due to prolonged in-hospital stays, frequent re-admissions, expensive diagnostics, and the need for antibiotic therapy and/or surgical intervention. There is considerable room for improvement in DLI management, particularly in the early detection and treatment stages. Ultrasound, an easily applicable device available in almost every hospital, offers an unrecognized potential for the early detection of DLI. By increasing awareness about the …

Caring, 1977, V1 N1, Winter, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a quarterly patient education publication. This is the first issue and follows in place of a previous title, "Observer". This issue contains a history of medical education at IMMC, information on the hospital's accreditation, and news about staffing, publications, events, and other updates.

Caring, 1978, V2, N3, Summer, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a quarterly patient education publication. This issue has articles on research and treatment for stroke patients and on IMMC's emergency department, as well as news about staffing, publications, events, and other updates.

Caring, 1979, V3 N1, Spring, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a quarterly patient education publication. This issue has an article on the rise and prominence of ambulatory care as well as news about staffing, publications, events, and other updates.

Caring, 1979, V3 N2, Summer, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a quarterly patient education publication. This issue has an article with advice on how to navigate medical care as well as news about staffing, publications, events, and other updates.

There is a 10-year follow up to the "Tranquility Ball" and fundraising event with Buzz Aldrin in 1969. For more information on this event, see this issue of Around & About Illinois Masonic Medical Center.

Caring, 1980, V4 N2, Summer, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a quarterly patient education publication. This issue has articles on hospice care and an area hospital consortium, as well as news about staffing, publications, events, and other updates.

Caring, 1980 V4 N3, Fall/Winter, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a quarterly patient education publication. This issue has a history of the nursing school at IMMC on its 60th anniversary, as well as news about staffing, publications, events, and other updates.

This is the last issue the library has in this format. The title continues in a new format here: Caring, 1987 Winter

Changes Of Volatile Flavor Compounds In Cantonese Sausage Containing Sauce-Flavor Baijiu During Air-Drying, Nie Xin, Chen Hongfan, Mao Jingjing, Liu Dayu, Zhao Zhiping, Shen Caihong

Food and Machinery

Objective: This study aimed to improve the flavor of Cantonese sausage and innovate the product. Methods: The volatile flavor compounds in the Cantonese sausages containing sauce-flavor Baijiu air-dried for 0 day, 2 days and 4 days were detected by GC-MS, and the changes of volatile flavor compounds were analyzed by multivariate statistics. Results: A total of 39 volatile flavor compounds were detected through GC-MS technology, including 18 hydrocarbons, 12 esters, 2 aldehydes, 2 ethers, 1 alcohol, 1 acid, 1 ketone and 2 other compounds. Esters, aldehydes, alcohols and hydrocarbons significantly increased during air-drying, while ketones and ethers showed a trend …

Determination Of Cholic Acid And Derivative Residues In Eggs By Uplc-Ms/Ms, Zhou Yanhua, Ti Tao, Xu Wenyang, Wang Xiali, Xiang Jun, Yang Junwei

Food and Machinery

Objective: The pretreatment method of through-type solid-phase extraction was improved to be coupled with ultra performance liquid chromatography tandem mass spectrometry for detection of cholic acid，deoxycholic acid and dehydrochloric in eggs. Methods: The samples were extracted by methanol and purified by PRiME HLB，then separated on C₁₈（100 mm×2.1 mm，3.0 μm） column with methanol-0.1% ammonia as the mobile phase for gradient elution. Meanwhile，the samples were quantified by external standard with negative ion select reaction monitoring （SRM） mode. Results: The results showed that the linear relationships of cholic acid （CA），deoxycholic acid （DCA） and dehydrochloric acid（DHCA） were good in the range from …

Design Of Automatic Processing Production Line For Fresh Corn, Niu Huli, Zhang Haoyu, Chang Hongjie, Guo Minghao, Yan Haipeng

Food and Machinery

Objective: It solved the problem of low accuracy and large random error when cutting fresh corn, which is easy to damage the grain. Methods: A new process of sweet and waxy corn processing production line was designed, the production line used machine vision technology to judge the attitude of corn, completed the adjustment of corn attitude through reversing equipment, designed adaptive positioning structure to cut the head and tail of corn, and then carried out layer retention processing according to the difference characteristics of ear bract adhesion after cutting results, packed after camera quality screening, and used prototype to carry …

Research Progress Of Visual Information Communication In Food Packaging: A Systematic Review, Tang Cong, Liu Zongming

Food and Machinery

To further develop scientific food packaging design methods, providing consumers with more accurate and prompt food packaging information, the article comprehensively analyzed three types of key cues for food packaging information communication: textual information, food imagery and cross-modal correspondence by integrating domestic and international related literature, and pointed out that textual information was more advantageous in the process of conveying information, positive slogans are more influential, and other detailed information would reduce consumer cognitive bias. Text is more suitable for expressing food functions, while pictures are more suitable for expressing sensory appeals. Secondly, package imagery had a significant impact on …

The Growth And Decline Of Bacterium During The Processing Of Meat Jujube, Zhou Xiao, Yin Hanliang, Tan Yisheng, Sun Junhua, Liu Yang

Food and Machinery

Objective: In order to determine the key control points that cause samples bagging and strengthen the prevention and control of microbial contamination during the processing of meat dates. Methods: Traditional microbial culture method combined with high-throughput DNA sequencing method was used to analyze the changes of bacterium during the processing of meat jujube and swollen bag of samples. Results: The total number of colonies basis was low in soft bones, while in the chicken skin reached to 9.10×10⁴ CFU/g. And the total number of colonies decreased to 30 CFU/g after cooking, but increased significantly after vacuum packaging, indicated a …

Effect Of Uv Sterilization On The Quality Of Grass Carp Meat During The Chilling Storage, Yuan Liping, Peng Bin, Zhong Bizhen, Hu Mingming, Li Jinlin

Food and Machinery

Objective： The effect of UV sterilization on the texture quality and flavor substances of the frozen grass carp meat was studied, and the best UV irradiation time was determined. Methods: The grass carp meat was pretreated with different UV irradiation times （0, 30, 60, 90, 150 min） at 30 W of UV radiation, then the quality parameters （apparent morphology, total number of bacteria on the surface of fish, juice loss rate, texture parameters, color, odor and sensory） and volatile components of the fish meat during chilling storage （0, 3, 6, 9 d） were measured. Results: It showed that the longer …

Effects Of Ultra-High Pressure Treatment On Bacterial Diversity Of Epinephelus Coioides During Refrigeration, Huang Li, Pang Tingcai, Qi Cen, Chen Deqiang

Food and Machinery

Objective: This study focused on the effectively control of the spoilage and deterioration of grouper during refrigeration. Methods: Illumina high-throughput sequencing technology was used to amplify the 16S rDNA V3-V4 segment of bacteria, then analyzed the changes in the bacterial community structure of E. obliquus after being treated with 400 MPa UHP for 5 minutes and refrigerated at 4 ℃ for 3, 6, 9, and 12 d. Results: According to Alpha diversity analysis fish samples treated with and without UHP showed increasing Chao1 and Ace indices as refrigeration times were extended, but Shannon indices progressively dropped. Nonetheless, the fish samples …

The Influence Of Stacking Mode And Air Supply Power On Cooling Effect Of Cold Storage, Xu Jing, Wang Feng, Tan Zhenhua, Lu Qiufang

Food and Machinery

Objective: Reasonable planning of the stacking of goods in the mobile cold storage and reasonable design of the air supply power of the fan, to reduce cold storage energy consumption and improve economic efficiency. Methods: A three-dimensional physical model and k-ε mathematical model of a certain cold storage were established, and the temperature field inside the cold storage under different stacking methods of goods and different air supply power were simulated using Fluent software. Results: The research results showed that under the same working conditions, the average storage temperature of goods horizontally was 2.014 ℃, and the average storage temperature …

Anti-Fatigue Effect Of Hemp Seed Oligopeptide In Mice And Its Sex Difference, Miao Wenyu, Li Yunfei, Song Lulu, Wang Jingjing, Cheng Jianjun, Qin Nan

Food and Machinery

Objective: To explore the anti-fatigue effect of hemp seed oligopeptides, and its effect and mechanism between male and female individuals. Methods: Equal number of male and female mice were randomly divided into a blank control group, a positive control group and low, medium and high dose groups. The blank control group was given normal saline, the positive control group was given whey protein. Gavage treatment was carried out with the corresponding drug for 28 days. Body weight, exhaustive swimming time, blood lactic acid （BLA）, urea nitrogen （BUN）, liver glycogen （LG） contents of mice were measured. Results: Regardless of gender, flax …

Effect Of Polyphenol Compound Formula On Relieving Exercise Fatigue In Mice, Fu Mengfan, Zhang Chun, Liu Binghao, Liu Suwen, Shi Donglin, Liu Jing, Chang Xuedong

Food and Machinery

Objective： This study aimed to explore the fatigue relieving effect of Lonicera caerulea Berry polyphenol, hawthorn polyphenol microcapsules, lactoferrin and vitamin C as polyphenol compound formula to alleviate fatigue. Methods： The commercial sports nutrition food with the compound formula of creatine, β-hydroxy-β-methylbutyrate, fructose diphosphate, taurine, vitamin B₆ and watermelon powder was used as the positive control. The experiment of exhaustive swimming in mice was carried out. The fatigue related indexes were determined by the kit, and the microscopic pathological tissues of the organs were observed by H&E staining. Results： There was no significant difference in body …

Antioxidant Activity And Α-Glucosidase Inhibitory Activity Of Five Banana Pulp Polyphenols, Ran Jingfeng, Chen Xiaoai, Yi Cuiping, Zhang Yanjun

Food and Machinery

Objective: The purpose of this study was to compare the activity difference of polyphenols in banana pulp of different varieties and to provide scientific basis for the exploitation and utilization of banana pulp polyphenols. Methods: Five banana pulp polyphenols were extracted by ultrasonic extraction, and the phenolic components were analyzed by ultra-high performance liquid chromatography （UHPLC）. The antioxidant capacity and inhibition ability of α-glucosidase were determined. Results: The total polyphenols, flavonoids and tannins content were significant differences among five varieties （P＜0.05）. Eight phenolic compounds were identified in five banana pulps, including four phenolic acids and their derivatives, …

Optimization Of Extraction Technology Of Iota Carrageenan By Ultrasonic Wave Combined With Enzyme, Xie Limei, Chen Jing, Zheng Huixin, Guo Shaoli, Zhang Ningning

Food and Machinery

Objective: This study focused on optimizing the Iota carrageenan extraction process and improving Iota carrageenan yield. Methods: Iota carrageenan was extracted from Eucheuma spinulosa by ultrasonic-assisted complex enzyme technology. Through single factor and orthogonal experiments, the optimum ratio of complex enzymes (cellulase, hemicellulose and papain) and enzymatic hydrolysis conditions of complex enzymes were first determined. Then, the optimum ultrasonic treatment conditions were determined. Finally, the boiling process conditions were optimized. Results: The optimal compound enzyme ratios were cellulase of 0.50%, hemicellulase of 1.25% and papain of 0.20%. The optimal enzymolysis conditions were as follows: enzymolysis at 60 ℃ and pH …

Research Trends On The Extraction Of Vegetable Oil By Aqueous Enzymatic Method, Guan Mengzhen, Chen Fusheng, Zhao Yuhui

Food and Machinery

Currently, vegetable oil is extracted by pressing method, solvent leaching method and aqueous enzymatic method. The aqueous enzymatic method has the advantages of high oil extraction rate, simple process and good oil quality compared with the pressing method and solvent leaching method. It also reduces the environmental pollution and improves the economic benefits. The review summarized the principle, process flow, characteristics, types of commonly used enzyme preparation, demulsification and vegetable oil quality of vegetable oil production by aqueous enzyme method, and the development trend of vegetable oil preparation by aqueous enzymatic method was prospected.

Research Progress On Extraction Technology, Nutritional Ingredient And Health Benefit Of Grape Seed Oil, Meng Yuzhu, Lei Changgui, Chen Jinping, Zhang Xiaodong, Zhang Zhiqian

Food and Machinery

Grape pomace is a major by-product produced during grape processing, including grape skin, pulp and seed. Grape seed oil (GSO) obtained from grape seeds is one of the vegetable oil with high nutritional value. It is rich in nutrients such as polyunsaturated fatty acids, tocopherols, phytosterols and phenols. It has many physiological effects such as antioxidant, anti-inflammatory, hypolipidemic, weight loss and antibacterial. Based on the relevant research reports at home and abroad in recent years, this review systematically summarized the extraction technologies, nutritional compositions and health effects of GSO. The research and development direction of GSO in the future was …

Research Progress On The Effects Of Ultrafine Grinding Technology On Nutrients And Specific Physiological Functions Of Grain Products, Yang Lei, Jia Yanju, Liu Jingke, Sheng Qinghai, Wang Yunting

Food and Machinery

Ultrafine grinding is an advanced technology that can grind materials down to the micron or even nanometer level, with significant advantages of material savings, fast grinding speed, and uniform and fine powder particle size. Recently, it has gradually been applied in the pre-treatment of grain crops, which has positive significance for the production of food with good taste, a high nutritional material dissolution rate, and strong functionality. This review summarizes the classification, advantages, and disadvantages of 7 different types of ultrafine grinding technology. The effect of ultrafine grinding technology on the nutrients (protein, starch, fat, dietary fiber and phenolic compound) …

Progress In Research On Fresh-Keeping, Storage And Processing Technology Of Cistanche Deserticola, Zhu Zhipeng, Bai Yujia

Food and Machinery

Cistanche deserticola is one of the precious traditional Chinese medicines that can be eaten fresh. Its highly active life and zoning restrictions cause it to brown, soften, and even mildew when being transported and stored. The processing technology and preservation and storage techniques were analyzed by thoroughly reading literatures in this field. Moreover, the advantages and disadvantages of different processing methods were analyzed, and the development direction of C. deserticola processing technology was prospected.

Status Of Clinical Research On Arginine And Its Application In Food For Special Medical Purpose, Chen Yao, Cao Ping, Chen Juan, Yuan Songmei, Li Wei

Food and Machinery

In recent years, arginine has received extensive attention from researchers and scholars in the field of food and nutrition because of its important role in patients' postoperative recovery and cardiovascular health. This article describes the metabolic pathways, physiological functions, absorption and intake of arginine, summarizes the application of arginine in clinical research and food for special medical purpose, and the future direction of development and research of the food for special medical purpose is also prospected.

Analysis Of The Elements And Development Trends Of Cereal Meal Replacement Powder, Yang Ruifang, Bai Jianjiang, Tang Jianhao, Piao Zhongze, Wan Changzhao, Xu Weiqin

Food and Machinery

Cereals are enriched with many nutrients that are good for human health. Cereal meal replacement powder interventions can reduce weight, improve blood lipids, regulate postprandial glucose, adjuvant treatment and prevention of diabetes, and have a wide range of applications and development prospects. In this review, the processing materials, efficacy, formulation optimization methods, digestive properties, processing techniques, and related implementation standards for meal replacements are summarized, and the development of meal replacements is prospected.

Quantum Chemistry Calculation Of Antioxidant Synergistic Effect Of Resveratrol And Sesamol In Oil, Gao Weihong, Qu Xiaodi, Yao Yunping, Li Changmo

Food and Machinery

Objective: This study focused on the antioxidant synergistic mechanism between resveratrol and sesamol. Methods: The levels of free radicals and peroxide free radicals in sunflower seed oil were assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide assays, respectively. The proportion of resveratrol and sesamol were optimized by integrating the measurements with the determination of the induction period. Additionally, quantum chemical simulations were employed to elucidate the underlying reaction processes. Results: Upon heating sunflower seed oil supplemented with resveratrol and sesamol at 180 ℃ for 2 hours, the total content of free radicals was determined as （0.08±0.03） mol/L and （0.20±0.03） mol/L, …

Study On Changes In Tenderness Of Yanbian Cattle During Dry And Wet-Aging, Zhang Boyuan, Sun Depeng, Wang Yuhan, Tian Jingyi, Mu Baide, Cui Mingxun, Li Guanhao

Food and Machinery

Objective: This study aimed to investigate the changes of beef tenderness during dry and wet-aging. Methods: Yanbian cattle was used as material to determine the changes in shear force, pH, moisture content, myofibrillar fragmentation index, protein degradation and histological properties of muscle fibers within 30 days after dry and wet-aging. Results: With the extension of aging time, the shear force of dry and wet aging beef samples decreased significantly, and the shear force decreased from 91.7 N to 51.6 N and 39.8 N at 30 days of aging, respectively. The myofibrillar fragmentation index and myofibrillar protein degradation changed significantly. After …