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Carbon Dioxide Availability In Inlands Rivers Is Driven By Dissolved Organic Carbon, Not Warming: A Case Study Of Tigris River, Batool Kadhim, Mohammed Hamdan Jun 2024

Carbon Dioxide Availability In Inlands Rivers Is Driven By Dissolved Organic Carbon, Not Warming: A Case Study Of Tigris River, Batool Kadhim, Mohammed Hamdan

Baghdad Science Journal

Rivers became supersaturated with carbon dioxide (CO2), so they play an essential role in the global carbon budgets. To increase our understanding of the source of CO2 availability in rivers, we studied the role of climate-changed drivers of CO2 availability, which are ‘‘dissolved organic carbon (DOC), and warming’’. We sampled 45 locations of 3 parts within the Tigris River in Baghdad during autumn and winter. The results showed that all the studied variables (water temperature, pH, DOC, CO2) changed over time. The variations in CO2 availability are associated with changes in DOC concentration, not with water temperature. Overall, our results …


Non-Invasive Brain Stimulation As Treatment For Motor Impairment In People With Parkinson's Disease: Protocol For An Umbrella Review, Dale M. Harris, Steven J. O'Bryan, Christopher Latella Jun 2024

Non-Invasive Brain Stimulation As Treatment For Motor Impairment In People With Parkinson's Disease: Protocol For An Umbrella Review, Dale M. Harris, Steven J. O'Bryan, Christopher Latella

Research outputs 2022 to 2026

Background Parkinson's disease (PD) is a progressive neurodegenerative disorder that predominantly affects movement and currently has no cure. Alongside medication, non-invasive brain stimulation (NIBS) may be used as an adjunct therapy to attenuate the motor symptoms experienced by people with PD. However, there is considerable heterogeneity in the evidence exploring the effects of NIBS for improving aspects of physical function in people with PD. Therefore, this protocol paper will outline the objectives, structure and procedure of a proposed umbrella review which will comprehensively summarise and map the current body evidence on the effectiveness of NIBS for improving physical function in …


Predicting Mortality Within 1 Year Of Art Initiation In Children And Adolescents Living With Hiv In Sub-Saharan Africa: A Retrospective Observational Cohort Study, Alexander Kay, Bhekumusa Lukhele, Sandile Dlamini, Abigail Seeger, Phumzile Dlamini, Sandile Ndabezitha, Nobuhle Mthethwa, Teresa Steffy, Lilian Komba, Pauline Amuge, Eunice Ketangenyi, Peter Elyanu, Adamson Munthali, Amos Msekandiana, Yvonne Maldonado, Elizabeth Chiao, Adeodata Kekitiinwa, Lineo Thahane, Lumumba Mwita, H Lester Kirchner, Anna Maria Mandalakas Jun 2024

Predicting Mortality Within 1 Year Of Art Initiation In Children And Adolescents Living With Hiv In Sub-Saharan Africa: A Retrospective Observational Cohort Study, Alexander Kay, Bhekumusa Lukhele, Sandile Dlamini, Abigail Seeger, Phumzile Dlamini, Sandile Ndabezitha, Nobuhle Mthethwa, Teresa Steffy, Lilian Komba, Pauline Amuge, Eunice Ketangenyi, Peter Elyanu, Adamson Munthali, Amos Msekandiana, Yvonne Maldonado, Elizabeth Chiao, Adeodata Kekitiinwa, Lineo Thahane, Lumumba Mwita, H Lester Kirchner, Anna Maria Mandalakas

Faculty, Staff and Students Publications

BACKGROUND: Differentiated service delivery (DSD) for children and adolescents living with HIV can improve targeted resource use. We derived a mortality prediction score to guide clinical decision making for children and adolescents living with HIV.

METHODS: Data for this retrospective observational cohort study were evaluated for all children and adolescents living with HIV and initiating antiretroviral therapy (ART); aged 0-19 years; and enrolled at Baylor clinics in Eswatini, Malawi, Lesotho, Tanzania, and Uganda between 2005 and 2020. Data for clinical prediction, including anthropometric values, physical examination, ART, WHO stage, and laboratory tests were captured at ART initiation. Backward stepwise variable …


Atep 588.50: Healthcare Administration & Leadership In Athletic Training, Valerie J. Moody Jun 2024

Atep 588.50: Healthcare Administration & Leadership In Athletic Training, Valerie J. Moody

University of Montana Course Syllabi, 2021-2025

No abstract provided.


The Metamorphoses Of Racial Discrimination In American Real Estate, Stevie J. Swanson Jun 2024

The Metamorphoses Of Racial Discrimination In American Real Estate, Stevie J. Swanson

Minnesota Journal of Law & Inequality

No abstract provided.


Selection Of Host Plants For Production Of Clanis Bilineata (Lepidoptera: Sphingidae), Xiaofeng Li, Mingming Guo, Kebin Li, Song Li, Honglin Feng, Jiwei Fan Jun 2024

Selection Of Host Plants For Production Of Clanis Bilineata (Lepidoptera: Sphingidae), Xiaofeng Li, Mingming Guo, Kebin Li, Song Li, Honglin Feng, Jiwei Fan

Faculty Publications

Clanis bilineata Walker (Lepidoptera: Sphingidae), a burgeoning edible insect, is experiencing rising demand in China and other regions. Despite this interest, larval production is currently constrained by the limitations of artificial production technologies, particularly the selection of optimal host plants. This study rigorously evaluated the performance of C. bilineatha larvae on four main host plants: round-leaf soybean, pointed-leaf soybean, black locust, and kudzu. Preference tests demonstrated that the larvae were most attracted to black locust (34.76 ± 4.65%), with subsequent preferences for kudzu (25.00 ± 6.12%), round-leaf soybean (23.17 ± 2.79%), and pointed-leaf soybean (14.02 ± 4.74%). No significant preference …


Pea Leaf Weevil, Sitona Lineatus (L.) (Coleoptera: Curculionidae), Adult Feeding Preference And Larval Development On Pulse Crop Varieties In Montana, Pragya Kiju, Kevin W. Wanner, Michael Ivie, Kevin Mcphee, Gadi V.P. Reddy Jun 2024

Pea Leaf Weevil, Sitona Lineatus (L.) (Coleoptera: Curculionidae), Adult Feeding Preference And Larval Development On Pulse Crop Varieties In Montana, Pragya Kiju, Kevin W. Wanner, Michael Ivie, Kevin Mcphee, Gadi V.P. Reddy

Faculty Publications

BACKGROUND: Montana accounts for approximately 45% of US dry pea production and the pea leaf weevil (PLW; Sitona lineatus (L.)) is the most common insect pest in this region. After crop emergence adult PLW feed on the foliage to mature and subsequently mate, and the soil-dwelling larvae feed and develop on the nitrogen-fixing root nodules. Producers commonly apply prophylactic insecticide treatments to the seed at planting as well as one or two post-emergent insecticide sprays to control PLW damage. To develop alternative management strategies based on integrated pest management (IPM), this field study evaluated pulse crops grown in Montana for …


Hepatic Interoception In Health And Disease, Hans Rudolf Berthoud, Heike Münzberg, Christopher D. Morrison, Winfried L. Neuhuber Jun 2024

Hepatic Interoception In Health And Disease, Hans Rudolf Berthoud, Heike Münzberg, Christopher D. Morrison, Winfried L. Neuhuber

Division of Basic Science Faculty Publications

The liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific sensory and motor components of both vagal and spinal access pathways to the hepatic parenchyma is missing. Lack of progress …


Inhalation Of Particulate Matter Containing Environmentally Persistent Free Radicals Induces Endothelial Dysfunction Mediated Via Ahr Activation At The Air-Blood Interface, Ankit Aryal, Ashlyn C. Harmon, Kurt J. Varner, Alexandra Noël, Stephania A. Cormier, Divine B. Nde, Peter Mottram, Jemiah Maxie, Tammy R. Dugas Jun 2024

Inhalation Of Particulate Matter Containing Environmentally Persistent Free Radicals Induces Endothelial Dysfunction Mediated Via Ahr Activation At The Air-Blood Interface, Ankit Aryal, Ashlyn C. Harmon, Kurt J. Varner, Alexandra Noël, Stephania A. Cormier, Divine B. Nde, Peter Mottram, Jemiah Maxie, Tammy R. Dugas

Division of Basic Science Faculty Publications

Particulate matter (PM) containing environmentally persistent free radicals (EPFR) is formed by the incomplete combustion of organic wastes, resulting in the chemisorption of pollutants to the surface of PM containing redox-Active transition metals. In prior studies in mice, EPFR inhalation impaired endothelium-dependent vasodilation. These findings were associated with aryl hydrocarbon receptor (AhR) activation in the alveolar type-II (AT-II) cells that form the air-blood interface in the lung. We thus hypothesized that AhR activation in AT-II cells promotes the systemic release of mediators that promote endothelium dysfunction peripheral to the lung. To test our hypothesis, we knocked down AhR in AT-II …


Anoctamin 4 Defines Glucose-Inhibited Neurons In The Ventromedial Hypothalamus, Longlong Tu, Yanlin He, Yong Xu Jun 2024

Anoctamin 4 Defines Glucose-Inhibited Neurons In The Ventromedial Hypothalamus, Longlong Tu, Yanlin He, Yong Xu

Division of Basic Science Faculty Publications

No abstract provided.


Estrogen Counteracts Age-Related Decline In Beige Adipogenesis Through The Nampt-Regulated Er Stress Response, Jooman Park, Ruoci Hu, Yanyu Qian, Shaolei Xiong, Asma Sana El-Sabbagh, Meram Ibrahim, Jaden Wang, Ziqiao Xu, Zhengjia Chen, Qing Song, Zhenyuan Song, Gege Yan, Abeer M. Mahmoud, Yanlin He, Brian T. Layden, Jiwang Chen, Sang Ging Ong, Pingwen Xu, Yuwei Jiang Jun 2024

Estrogen Counteracts Age-Related Decline In Beige Adipogenesis Through The Nampt-Regulated Er Stress Response, Jooman Park, Ruoci Hu, Yanyu Qian, Shaolei Xiong, Asma Sana El-Sabbagh, Meram Ibrahim, Jaden Wang, Ziqiao Xu, Zhengjia Chen, Qing Song, Zhenyuan Song, Gege Yan, Abeer M. Mahmoud, Yanlin He, Brian T. Layden, Jiwang Chen, Sang Ging Ong, Pingwen Xu, Yuwei Jiang

Division of Basic Science Faculty Publications

Thermogenic beige adipocytes are recognized as potential therapeutic targets for combating metabolic diseases. However, the metabolic advantages that they offer are compromised with aging. Here we show that treating mice with estrogen (E2), a hormone that decreases with age, can counteract the age-related decline in beige adipogenesis when exposed to cold temperature while concurrently enhancing energy expenditure and improving glucose tolerance in mice. Mechanistically, we found that nicotinamide phosphoribosyl transferase (NAMPT) plays a pivotal role in facilitating the formation of E2-induced beige adipocytes, which subsequently suppresses the onset of age-related endoplasmic reticulum (ER) stress. Furthermore, we found that targeting NAMPT …


Accelerated Onset Of Diabetes In Non-Obese Diabetic Mice Fed A Refined High-Fat Diet, Heidi M. Batdorf, Luz De Luna Lawes, Gabrielle A. Cassagne, Molly S. Fontenot, Innocence C. Harvey, Jeremy T. Richardson, David H. Burk, Samuel D. Dupuy, Michael D. Karlstad, J. Michael Salbaum, Jaroslaw Staszkiewicz, Robbie Beyl, Sujoy Ghosh, Susan J. Burke, J. Jason Collier Jun 2024

Accelerated Onset Of Diabetes In Non-Obese Diabetic Mice Fed A Refined High-Fat Diet, Heidi M. Batdorf, Luz De Luna Lawes, Gabrielle A. Cassagne, Molly S. Fontenot, Innocence C. Harvey, Jeremy T. Richardson, David H. Burk, Samuel D. Dupuy, Michael D. Karlstad, J. Michael Salbaum, Jaroslaw Staszkiewicz, Robbie Beyl, Sujoy Ghosh, Susan J. Burke, J. Jason Collier

Division of Basic Science Faculty Publications

Aim: Type 1 diabetes results from autoimmune events influenced by environmental variables, including changes in diet. This study investigated how feeding refined versus unrefined (aka ‘chow’) diets affects the onset and progression of hyperglycaemia in non-obese diabetic (NOD) mice. Methods: Female NOD mice were fed either unrefined diets or matched refined low- and high-fat diets. The onset of hyperglycaemia, glucose tolerance, food intake, energy expenditure, circulating insulin, liver gene expression and microbiome changes were measured for each dietary group. Results: NOD mice consuming unrefined (chow) diets developed hyperglycaemia at similar frequencies. By contrast, mice consuming the defined high-fat diet had …


Associations Between Daily Step Count Classifications And Continuous Glucose Monitoring Metrics In Adults With Type 1 Diabetes: Analysis Of The Type 1 Diabetes Exercise Initiative (T1dexi) Cohort, Lauren V. Turner, Martin Chase Marak, Robin L. Gal, Peter Calhoun, Zoey Li, Peter G. Jacobs, Mark A. Clements, Corby K. Martin, Francis J. Doyle, Susana R. Patton, Jessica R. Castle, Melanie B. Gillingham, Roy W. Beck, Michael R. Rickels, Michael C. Riddell Jun 2024

Associations Between Daily Step Count Classifications And Continuous Glucose Monitoring Metrics In Adults With Type 1 Diabetes: Analysis Of The Type 1 Diabetes Exercise Initiative (T1dexi) Cohort, Lauren V. Turner, Martin Chase Marak, Robin L. Gal, Peter Calhoun, Zoey Li, Peter G. Jacobs, Mark A. Clements, Corby K. Martin, Francis J. Doyle, Susana R. Patton, Jessica R. Castle, Melanie B. Gillingham, Roy W. Beck, Michael R. Rickels, Michael C. Riddell

Clinical Research Faculty Publications

Aims/hypothesis: Adults with type 1 diabetes should perform daily physical activity to help maintain health and fitness, but the influence of daily step counts on continuous glucose monitoring (CGM) metrics are unclear. This analysis used the Type 1 Diabetes Exercise Initiative (T1DEXI) dataset to investigate the effect of daily step count on CGM-based metrics. Methods: In a 4 week free-living observational study of adults with type 1 diabetes, with available CGM and step count data, we categorised participants into three groups—below (< 7000), meeting (7000–10,000) or exceeding (>10,000) the daily step count goal—to determine if step count category influenced CGM metrics, including per cent time …


Effect Of Long-Term Caloric Restriction On Telomere Length In Healthy Adults: Calerie™ 2 Trial Analysis, Waylon J. Hastings, Qiaofeng Ye, Sarah E. Wolf, Calen P. Ryan, Sai Krupa Das, Kim M. Huffman, Michael S. Kobor, William E. Kraus, Julia L. Macisaac, Corby K. Martin, Susan B. Racette, Leanne M. Redman, Daniel W. Belsky, Idan Shalev Jun 2024

Effect Of Long-Term Caloric Restriction On Telomere Length In Healthy Adults: Calerie™ 2 Trial Analysis, Waylon J. Hastings, Qiaofeng Ye, Sarah E. Wolf, Calen P. Ryan, Sai Krupa Das, Kim M. Huffman, Michael S. Kobor, William E. Kraus, Julia L. Macisaac, Corby K. Martin, Susan B. Racette, Leanne M. Redman, Daniel W. Belsky, Idan Shalev

Clinical Research Faculty Publications

Caloric restriction (CR) modifies lifespan and aging biology in animal models. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE™) 2 trial tested translation of these findings to humans. CALERIE™ randomized healthy, nonobese men and premenopausal women (age 21–50y; BMI 22.0–27.9 kg/m2), to 25% CR or ad-libitum (AL) control (2:1) for 2 years. Prior analyses of CALERIE™ participants' blood chemistries, immunology, and epigenetic data suggest the 2-year CR intervention slowed biological aging. Here, we extend these analyses to test effects of CR on telomere length (TL) attrition. TL was quantified in blood samples collected at baseline, 12-, …


Increasing Mowing Height And Nitrogen Fertility Does Not Enhance Unirrigated Centipedegrass Summer Drought Stress, Mike Adams, Jeffrey Beasley, Jeff Kuehny, Dylan Watson Jun 2024

Increasing Mowing Height And Nitrogen Fertility Does Not Enhance Unirrigated Centipedegrass Summer Drought Stress, Mike Adams, Jeffrey Beasley, Jeff Kuehny, Dylan Watson

Faculty Publications

Proper N fertilization and higher mowing heights are recommended to enhance rooting for greater turfgrass summer drought stress. To examine the effects of these primary cultural practices on centipedegrass [Eremochloa ophiuroides (Munro) Hack.] drought response in the mid-Southern United States, a study was conducted to evaluate four mowing heights (1, 2, 3 and 4 inches) and N fertilization versus no fertilization. During the study, roots were periodically harvested at upper (0–3 inches) and lower (3–6 inches) soil depths, and roots were analyzed for architecture which included root length (RL) and surface area (SA), and root weight (RW). In July, plant-soil …


Phytochemical Profiling And Bioactive Potential Of Grape Seed Extract In Enhancing Salinity Tolerance Of Vicia Faba, Doaa E. Elsherif, Fatmah A. Safhi, Prasanta K. Subudhi, Abdelghany S. Shaban, Mai A. El-Esawy, Asmaa M. Khalifa Jun 2024

Phytochemical Profiling And Bioactive Potential Of Grape Seed Extract In Enhancing Salinity Tolerance Of Vicia Faba, Doaa E. Elsherif, Fatmah A. Safhi, Prasanta K. Subudhi, Abdelghany S. Shaban, Mai A. El-Esawy, Asmaa M. Khalifa

Faculty Publications

Salinity stress poses a significant threat to crop productivity worldwide, necessitating effective mitigation strategies. This study investigated the phytochemical composition and potential of grape seed extract (GSE) to mitigate salinity stress effects on faba bean plants. GC–MS analysis revealed several bioactive components in GSE, predominantly fatty acids. GSE was rich in essential nutrients and possessed a high antioxidant capacity. After 14 days of germination, GSE was applied as a foliar spray at different concentrations (0, 2, 4, 6, and 8 g/L) to mitigate the negative effects of salt stress (150 mM NaCl) on faba bean plants. Foliar application of 2–8 …


Nutritive Value And Forage Accumulation Of A Black Oat Germplasm In The Northeastern United States, David M. Jaramillo, Kathy Soder, Ann Blount, Jose C.B. Dubeux, Stephen Harrison Jun 2024

Nutritive Value And Forage Accumulation Of A Black Oat Germplasm In The Northeastern United States, David M. Jaramillo, Kathy Soder, Ann Blount, Jose C.B. Dubeux, Stephen Harrison

Faculty Publications

Black oat (Avena strigosa Schreb.) might be an attractive forage species in the northeastern United States, since it is generally more heat tolerant and disease resistant than other cool-season grasses. Black oat is currently recommended for fall and winter production in USDA Plant Hardiness ones 8b–10a, which is beyond the northeastern United States (Zones 2a–6a). The objective was to evaluate 10 black oat breeding lines (referred to as “UF1” through “UF10”) for forage accumulation, crude protein (CP), neutral detergent fiber (aNDF), acid detergent fiber (ADF), and in vitro digestible organic matter (IVDOM) concentrations. The experiment was carried out in April–July …


Fisheries Occasional Publication No.147 - Aquaculture Development Zones – Policy Position Relating To Permitted Alternative Species, Department Of Primary Industries And Regional Development, Western Australia Jun 2024

Fisheries Occasional Publication No.147 - Aquaculture Development Zones – Policy Position Relating To Permitted Alternative Species, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Occasional Publications

The purpose of this policy is to set out considerations relevant to the assessment of aquaculture proposals within Aquaculture Development Zones (ADZ) for species distinct from the group of species for which the ADZ was initially established (Alternative Species).


Gestational Diabetes Mellitus And Postpartum Hypertension: Evidence For A Tight Linkage Toward Women's Cardiovascular Health, Yun Shen, Gang Hu Jun 2024

Gestational Diabetes Mellitus And Postpartum Hypertension: Evidence For A Tight Linkage Toward Women's Cardiovascular Health, Yun Shen, Gang Hu

Population and Public Health Science Faculty Publications

No abstract provided.


A Retrospective Review: Oxford County Wellness Collaborative's Contributions To Community Health, Emma Schwartz, Rachel T. Gallo Mph Jun 2024

A Retrospective Review: Oxford County Wellness Collaborative's Contributions To Community Health, Emma Schwartz, Rachel T. Gallo Mph

Publications

Since 2011, Oxford County Wellness Collaborative (OCWC) has been transforming personal, environmental, and economic health by building strong relationships among people and organizations. OCWC contracted with the Data Innovation Project at the Catherine Cutler Institute of Health and Social Policy to synthesize previously collected or reported data and collect primary data to conduct a retrospective evaluation. The evaluation team used this data to convey past successes, better understand the outcomes of the collaborative to date, and provide recommendations for OCWC’s next steps in furthering its impact.


The Effectiveness Of Photo-Biomodulation Therapy In Oral Mucositis, Molly Amado, Kara Otts, Madeline Scott, Sophie Steffey, Katie Williams, Evelyn Zaragoza Jun 2024

The Effectiveness Of Photo-Biomodulation Therapy In Oral Mucositis, Molly Amado, Kara Otts, Madeline Scott, Sophie Steffey, Katie Williams, Evelyn Zaragoza

2023

No abstract provided.


Advancing Ocean Sustainability For Climate-Resilient Change, Teresa J. Kennedy Jun 2024

Advancing Ocean Sustainability For Climate-Resilient Change, Teresa J. Kennedy

Education Faculty Publications and Presentations

The United Nations (UN) Decade of Ocean Science for Sustainable Development spans from 2021 to 2030 as a global call to action for marine scientists and Early Career Ocean Professionals (ECOPs) to collaboratively create, implement, and communicate science-based solutions to the critical challenges faced by our shared Ocean. The Decade integrates science, policy, and international engagement of a broad base of civil society stakeholders through interdisciplinary research challenges aimed at establishing sustainable marine practices to confront issues related to climate change. This chapter presents a synopsis of the UN-led initiatives that culminated in the launch of the Ocean Decade and …


The Effects Of Occupational Disruption During Covid-19 Lockdowns On Health: A Cross-Sectional Study, Bernard Austin Kigunda Muriithi, R. Curtis Bay Jun 2024

The Effects Of Occupational Disruption During Covid-19 Lockdowns On Health: A Cross-Sectional Study, Bernard Austin Kigunda Muriithi, R. Curtis Bay

Communication Disorders and Occupational Therapy Faculty Publications and Presentations

The disruption in daily activity performance during COVID-19 lockdowns is widely understood to have impacted health, but a better understanding of how restricted performance of specific activities are associated with health is needed. This cross-sectional study answers the following question: How were changes in the performance of 16 daily activities associated with health during COVID-19 lockdowns? A total of 116 participants completed an online survey rating their health before and during COVID-19 lockdowns and comparing their recollection of the performance of 16 activities before COVID-19 with their performance during lockdowns. Multiple stepwise linear regression analysis was used to estimate the …


Animal Science Research Report 2024 (Complete Report), Department Of Animal Science Jun 2024

Animal Science Research Report 2024 (Complete Report), Department Of Animal Science

Animal Science Research Report 2024

This is the complete proceedings of the South Dakota State University, Department of Animal Science Research Report 2024. The report contains research on ruminant, non-ruminant, and meat science.


Nutritional Supplementation In Children With Severe Pneumonia In Uganda And Kenya (Coast-Nutrition): A Phase 2 Randomised Controlled Trial, Sarah Kiguli, Peter Olupot-Olupot, Mainga Hamaluba, Elisa Giallongo, Karen Thomas, Florence Alaroker, Robert Opoka, Abner Tagoola, Shela Oyella, Damalie Nalwanga Jun 2024

Nutritional Supplementation In Children With Severe Pneumonia In Uganda And Kenya (Coast-Nutrition): A Phase 2 Randomised Controlled Trial, Sarah Kiguli, Peter Olupot-Olupot, Mainga Hamaluba, Elisa Giallongo, Karen Thomas, Florence Alaroker, Robert Opoka, Abner Tagoola, Shela Oyella, Damalie Nalwanga

Paediatrics and Child Health, East Africa

Background Severe pneumonia in African children results in poor long-term outcomes (deaths/readmissions) with undernutrition as a key risk factor. We hypothesised additional energy/protein-rich Ready-to-Use Therapeutic Foods (RUTF) would meet additional nutritional requirements and improve outcomes.

Methods COAST-Nutrition was an open-label Phase 2 randomised controlled trial in children (aged 6 months-12 years) hospitalised with severe pneumonia (and hypoxaemia, SpO2 <92%) in Mbale, Soroti, Jinja, Masaka Regional Referral Hospitals, Uganda and Kilifi County Hospital, Kenya (ISRCTN10829073 (registered 6th June 2018) PACTR202106635355751 (registered 2nd June 2021)). Children were randomised (ratio 1:1) to enhanced nutritional supplementation with RUTF (plus usual diet) for 56 days vs usual diet (control). The primary outcome was change in mid-upper arm circumference (MUAC) at 90 days as a composite with mortality. Secondary outcomes include anthropometric status, mortality, and readmissions at Days 28, 90 and 180.

Findings Between 12 August 2018 and 22 April 2022, 846 eligible children were randomised, 424 to RUTF and 422 to usual diet, and followed for 180-days [12 (1%) lost-to-follow-up]. RUTF supplement was initiated in 417/419 (>99%). By Day 90, there was …


International Consensus On Standard Outcome Measures For Neurodevelopmental Disorders: A Consensus Statement, Melissa Mulraney, Umanga De Silva, Andria Joseph, Maria Da Luz Sousa Fialho, Iain Dutia, Natalie Munro, Jonathan M. Payne, Tobias Banaschewski, Cláudia Bandeira De Lima, Susan Wamithi Jun 2024

International Consensus On Standard Outcome Measures For Neurodevelopmental Disorders: A Consensus Statement, Melissa Mulraney, Umanga De Silva, Andria Joseph, Maria Da Luz Sousa Fialho, Iain Dutia, Natalie Munro, Jonathan M. Payne, Tobias Banaschewski, Cláudia Bandeira De Lima, Susan Wamithi

Paediatrics and Child Health, East Africa

Importance: The use of evidence-based standardized outcome measures is increasingly recognized as key to guiding clinical decision-making in mental health. Implementation of these measures into clinical practice has been hampered by lack of clarity on what to measure and how to do this in a reliable and standardized way.

Objective: To develop a core set of outcome measures for specific neurodevelopmental disorders (NDDs), such as attention-deficit/hyperactivity disorder (ADHD), communication disorders, specific learning disorders, and motor disorders, that may be used across a range of geographic and cultural settings.

Evidence Review: An international working group composed of clinical and research experts …


Soil Profile Distribution Of Nutrients In Contrasting Soils Amended With Struvite And Other Conventional Phosphorus Fertilizers, Tatum Simms, Kristofor R. Brye, Trenton L. Roberts, Lauren F. Greenlee Jun 2024

Soil Profile Distribution Of Nutrients In Contrasting Soils Amended With Struvite And Other Conventional Phosphorus Fertilizers, Tatum Simms, Kristofor R. Brye, Trenton L. Roberts, Lauren F. Greenlee

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Phosphorus (P) can be recovered from wastewater and used as an alternative fertilizer, namely, struvite [MgNH4PO4·6(H2O)]. However, the soil mobility of wastewater-derived P and other nutrients needs to be evaluated. The objective of this study was to compare the vertical distribution of water-soluble (WS) soil P and other nutrients from a synthetic-wastewater-derived electrochemically precipitated struvite (ECST) to that from a chemically precipitated struvite (CPST), triple superphosphate (TSP), monoammonium phosphate (MAP), and a control in six soils from Arkansas (AR; loam [L] and silt loam [SiL]), Missouri (MO; SiL 1 and SiL 2), and Nebraska …


Efficacy And Safety Of A Four-Drug, Quarter-Dose Treatment For Hypertension: The Quartet Usa Randomized Trial, Mark D Huffman, Et Al. Jun 2024

Efficacy And Safety Of A Four-Drug, Quarter-Dose Treatment For Hypertension: The Quartet Usa Randomized Trial, Mark D Huffman, Et Al.

2020-Current year OA Pubs

New approaches are needed to lower blood pressure (BP) given persistently low control rates. QUARTET USA sought to evaluate the effect of four-drug, quarter-dose BP lowering combination in patients with hypertension. QUARTET USA was a randomized (1:1), double-blinded trial conducted in federally qualified health centers among adults with hypertension. Participants received either a quadpill of candesartan 2 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg or candesartan 8 mg for 12 weeks. If BP was >130/>80 mm Hg at 6 weeks in either arm, then participants received open label add-on amlodipine 5 mg. The primary outcome …


Impact Of Low-Load Resistance Exercise With And Without Blood Flow Restriction On Muscle Strength, Endurance, And Oxidative Capacity: A Pilot Study, Brett H. Davis, James E. Stampley, Joshua Granger, Matthew C. Scott, Timothy D. Allerton, Neil M. Johannsen, Guillaume Spielmann, Brian A. Irving Jun 2024

Impact Of Low-Load Resistance Exercise With And Without Blood Flow Restriction On Muscle Strength, Endurance, And Oxidative Capacity: A Pilot Study, Brett H. Davis, James E. Stampley, Joshua Granger, Matthew C. Scott, Timothy D. Allerton, Neil M. Johannsen, Guillaume Spielmann, Brian A. Irving

Clinical Research Faculty Publications

Low-load resistance exercise (LLRE) to failure can increase muscle mass, strength, endurance, and mitochondrial oxidative capacity (OXPHOS). However, the impact of adding blood flow restriction to low-load resistance exercise (LLBFR) when matched for volume on these outcomes is incompletely understood. This pilot study examined the impact of 6 weeks of single-legged LLBFR and volume-matched LLRE on thigh bone-free lean mass, strength, endurance, and mitochondrial OXPHOS. Twenty (12 males and 8 females) untrained young adults (mean ± SD; 21 ± 2 years, 168 ± 11 cm, 68 ± 12 kg) completed 6 weeks of either single-legged LLBFR or volume-matched LLRE. Participants …


Optimizing Central Venous Access Simulation Training To Surgical Education Trends: A Hybrid Approach Of 3d Anatomy Technology And Flipped Classroom, Ung-Kai Ting, Ming-Hsien Chiang, Yung-Chih Wang, Chin-Sheng Lin, Jiunn-Tay Lee, Yuan-Ming Tsai Jun 2024

Optimizing Central Venous Access Simulation Training To Surgical Education Trends: A Hybrid Approach Of 3d Anatomy Technology And Flipped Classroom, Ung-Kai Ting, Ming-Hsien Chiang, Yung-Chih Wang, Chin-Sheng Lin, Jiunn-Tay Lee, Yuan-Ming Tsai

Journal of Medical Education

Purpose: Central venous catheterization is a critical skill in perioperative and critical care medicine. During their postgraduate-year training (PGY), postgraduate trainees are expected to perform central venous catheter (CVC) insertion. Despite learning anatomy in medical school, the demanding nature of the hospital environment requires continuous reinforcement of their knowledge. This pilot study examines the efficacy of three-dimensional (3D) anatomy technology in teaching vascular anatomy for CVC insertion through a flipped classroom approach. Methods: An educational 3D anatomy platform "Complete Anatomy" was utilized to create central-line vascular models to teach vascular anatomy. Trainees completed an online course and a self-assessment before …