Digital Commons Network^™

Comparative Toxicological Assessment Of 2 Bisphenols Using A Systems Approach: Evaluation Of The Behavioral And Transcriptomic Responses Of Danio Rerio To Bisphenol A And Tetrabromobisphenol A, Michael G Morash, Morgan W Kirzinger, John C Achenbach, Ananda B Venkatachalam, Jessica Nixon, Susanne Penny, Joëlle Pinsonnault Cooper, Deborah E Ratzlaff, Cindy L A Woodland, Lee D Ellis

Faculty, Staff and Student Publications

The zebrafish (Danio rerio) is becoming a critical component of new approach methods (NAMs) in chemical risk assessment. As a whole organism in vitro NAM, the zebrafish model offers significant advantages over individual cell-line testing, including toxicokinetic and toxicodynamic competencies. A transcriptomic approach not only allows for insight into mechanism of action for both apical endpoints and unobservable adverse outcomes, but also changes in gene expression induced by lower, environmentally relevant concentrations. In this study, we used a larval zebrafish model to assess the behavioral and transcriptomic alterations caused by subphenotypic concentrations of 2 chemicals with the same structural backbone, …

Anterior Solid Dual-Rod Instrumentation And Fusion For Flexible Thoracolumbar Or Lumbar Spinal Deformities In Adolescent Idiopathic Scoliosis., Mckenna C. Noe, Kenneth A. Furlough, Richard M. Schwend

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Anterior spinal instrumentation and fusion (ASIF) via a thoracolumbar approach has been used to treat Lenke 5 adolescent idiopathic scoliosis for decades. Advances in ASIF technique and instrumentation have yielded significant improvements in rates of instrumentation failure, need for reoperation, instrumented and adjacent segment kyphosis, and pseudarthrosis. Despite reports of ASIF's success using these strategies, a detailed technical description with illustrations of this procedure in the literature is lacking.

METHODS: We present a detailed illustrated surgical technique guide for anterior solid-rod instrumentation via a thoracoabdominal approach in the correction of a Lenke 5 adolescent idiopathic scoliosis deformity.

RESULTS: ASIF …

Intermittent Mechanical Loading On Mouse Tibia Accelerates Longitudinal Bone Growth By Inducing Pthrp Expression In The Female Tibial Growth Plate., Sarah Mcgarry, Karen Kover, Daniel P. Heruth, Mark Dallas, Xinxin Jin, Shufang Wu, Francesco De Luca

Manuscripts, Articles, Book Chapters and Other Papers

It is not clear as to whether weight bearing and ambulation may affect bone growth. Our goal was to study the role of mechanical loading (one of the components of ambulation) on endochondral ossification and longitudinal bone growth. Thus, we applied cyclical, biologically relevant strains for a prolonged time period (4 weeks) to one tibia of juvenile mice, while using the contralateral one as an internal control. By the end of the 4-week loading period, the mean tibial growth of the loaded tibiae was significantly greater than that of the unloaded tibiae. The mean height and the mean area of …

Why Do Patients With Cancer Die?, Adrienne Boire, Katy Burke, Thomas R Cox, Theresa Guise, Mariam Jamal-Hanjani, Tobias Janowitz, Rosandra Kaplan, Rebecca Lee, Charles Swanton, Matthew G Vander Heiden, Erik Sahai

Faculty, Staff and Student Publications

Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. Many patients with cancer experience reduced life expectancy and have metastatic disease at the time of death. However, the more precise causes of mortality and patient deterioration before death remain poorly understood. This scarcity of information, particularly the lack of mechanistic insights, presents a challenge for the development of novel treatment strategies to improve the quality of, and potentially extend, life for patients with late-stage cancer. In addition, earlier deployment of existing strategies to prolong quality of life is highly desirable. In this …

Pbi-05204, A Supercritical Co2 Extract Of Nerium Oleander, Suppresses Glioblastoma Stem Cells By Inhibiting Grp78 And Inducing Programmed Necroptotic Cell, Sharmistha Chakraborty, Daoyan Wei, Megan Tran, Frederick F Lang, Robert A Newman, Peiying Yang

Faculty, Staff and Student Publications

Successful treatment of glioblastoma multiforme (GBM), an aggressive form of primary brain neoplasm, mandates the need to develop new therapeutic strategies. In this study, we investigated the potential of PBI-05204 in targeting GBM stem cells (GSCs) and the underlying mechanisms. Treatment with PBI-05204 significantly reduced both the number and size of tumor spheres derived from patient-derived GSCs (GBM9, GSC28 and TS543), and suppressed the tumorigenesis of GBM9 xenografts. Moreover, PBI-05204 treatment led to a significant decrease in the expression of CD44 and NANOG, crucial markers of progenitor stem cells, in GBM9 and GSC28 GSCs. This treatment also down-regulated GRP78 expression …

Markov Models For Clinical Decision-Making In Radiation Oncology: A Systematic Review, Lucas B Mccullum, Aysenur Karagoz, Cem Dede, Raul Garcia, Fatemeh Nosrat, Mehdi Hemmati, Seyedmohammadhossein Hosseinian, Andrew J Schaefer, Clifton D Fuller

Faculty, Staff and Student Publications

The intrinsic stochasticity of patients' response to treatment is a major consideration for clinical decision-making in radiation therapy. Markov models are powerful tools to capture this stochasticity and render effective treatment decisions. This paper provides an overview of the Markov models for clinical decision analysis in radiation oncology. A comprehensive literature search was conducted within MEDLINE using PubMed, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Only studies published from 2000 to 2023 were considered. Selected publications were summarized in two categories: (i) studies that compare two (or more) fixed treatment policies using Monte Carlo simulation …

Pb-05204, A Supercritical Co2 Extract Of Nerium Oleander, Suppresses Glioblastoma Stem Cells By Inhibiting Grp78 And Inducing Programmed Necroptotic Cell Death, Sharmistha Chakraborty, Daoyan Wei, Megan Tran, Frederick F Lang, Robert A Newman, Peiying Yang

Faculty, Staff and Student Publications

Successful treatment of glioblastoma multiforme (GBM), an aggressive form of primary brain neoplasm, mandates the need to develop new therapeutic strategies. In this study, we investigated the potential of PBI-05204 in targeting GBM stem cells (GSCs) and the underlying mechanisms. Treatment with PBI-05204 significantly reduced both the number and size of tumor spheres derived from patient-derived GSCs (GBM9, GSC28 and TS543), and suppressed the tumorigenesis of GBM9 xenografts. Moreover, PBI-05204 treatment led to a significant decrease in the expression of CD44 and NANOG, crucial markers of progenitor stem cells, in GBM9 and GSC28 GSCs. This treatment also down-regulated GRP78 expression …

A Qualitative Exploration To Inform An Oral Health Training For Disability Care Workers In Burkina Faso, Ave Põld, Dan Filwendé Kientega, Jocelyne Valérie Garé, Michael Lorenz

Faculty, Staff and Student Publications

AIM: To explore enablers and barriers to the creation of an oral health training for care workers at specialized centres for children with disabilities in Ouagadougou.

DESIGN: This was a formative study informed by the Theoretical Domains Framework using qualitative methods.

METHODS: Qualitative observations and 14 semi-structured interviews were conducted with care workers from six specialized centres for disability.

RESULTS: Carer workers emphasized that a successful oral health training must account for available resources and competencies in each specific centre. Part of the training must be dedicated to oral hygiene targeted for people with disabilities and provide knowledge about risk …

Assessing The Reproducibility Of Research Based On The Food And Drug Administration Manufacturer And User Facility Device Experience Data, Xinyu Li, Yubo Feng, Yang Gong, You Chen

Faculty, Staff and Student Publications

Objective: This article aims to assess the reproducibility of Manufacturer and User Facility Device Experience (MAUDE) data-driven studies by analyzing the data queries used in their research processes.

Methods: Studies using MAUDE data were sourced from PubMed by searching for "MAUDE" or "Manufacturer and User Facility Device Experience" in titles or abstracts. We manually chose articles with executable queries. The reproducibility of each query was assessed by replicating it in the MAUDE Application Programming Interface. The reproducibility of a query is determined by a reproducibility coefficient that ranges from 0.95 to 1.05. This coefficient is calculated by comparing the number …

Why Do Patients With Cancer Die?, Adrienne Boire, Katy Burke, Thomas R Cox, Theresa Guise, Mariam Jamal-Hanjani, Tobias Janowitz, Rosandra Kaplan, Rebecca Lee, Charles Swanton, Matthew G Vander Heiden, Erik Sahai

Faculty, Staff and Student Publications

Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. Many patients with cancer experience reduced life expectancy and have metastatic disease at the time of death. However, the more precise causes of mortality and patient deterioration before death remain poorly understood. This scarcity of information, particularly the lack of mechanistic insights, presents a challenge for the development of novel treatment strategies to improve the quality of, and potentially extend, life for patients with late-stage cancer. In addition, earlier deployment of existing strategies to prolong quality of life is highly desirable. In this …

Understanding The Role Of The Microbiome In Infectious Disease, Developing Surveillance Tools, And Engineering Direct Fed Microbials To Improve Animal Health, Alison Clare (Bartenslager) Neujahr

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

With the ever-increasing demand for animal protein and the continual need for the assurance of proper animal welfare, investigations of preventative strategies for diseases is greatly needed. Specifically in the cattle industry, infectious bovine keratoconjunctivitis (IBK), commonly known as pinkeye, causes a large economic loss to the producer. However, effective mitigation strategies are lacking. Partly, this is due to the lack of studies investigating the ocular microbiome. Therefore, studies investigating the bovine ocular microbiome are greatly needed to better understand IBK disease etiology. To this end, we investigated the changes in the ocular microbiome in animals before, during and after …

Effect Of Cvd Education On The Perception And Modifiable Health Behaviors Of College Students, Sanitha Douglas

Doctor of Nursing Practice Projects

Background

Research reports that cardiovascular disease (CVD) has been a national and global health problem for many years, and that knowledge has increased regarding its prevention (Hennekens, 2020). However, according to Hennekens (2020), CVD remains the number one cause of death in America and most developed countries worldwide. The lack of perception and knowledge of actual CVD risk in the young adult population may be contributing to this deadly disease. This project evaluated the effectiveness of education on CVD risk perception and modifiable health behaviors of college students.

Purpose

This project’s purpose was to assess college students' perception of their …

On Counter-Memes: A Rhetorical Study Of Allyship In Social Media Memetics From 2015-2024, Kaitlyn Samons

All Dissertations

This dissertation examines the importance of Online allyship through a newly coined term in Memetics and Mis- and Disinformation: “Counter-Memeship.” This work combines previous contributing works on “memes,” “counter-memes,” “counter-stories,” and “allyship” through the lens of feminist, white, and communication theories. Internet memes and studies are explored by looking at how Online participants in internet spaces interact with each other in modern-day protests in memetic ways. The researcher utilizes descriptive and exploratory methods to articulate better how internet memes work between 2015 and 2024. The primary purpose of this research is to see whether Online protests can be considered non-performative …

How Far Does The Apple Fall? Intergenerational Processes Underlying The Attainment Of Decent Work And Implications For Occupational Health And Well-Being, Baylor A. Graham

All Dissertations

Despite decades of progress spurred by the Decent Work Agenda (International Labor Organization, 1999), efforts to improve working conditions, ensure fair wages, and establish health and well-being as fundamental standards in employment practices continue to be sorely needed. The burden of inadequate decent work has demonstrated profound effects on individual health and well-being. However, the effects of inadequate decent work are rarely investigated over long periods of time and are entirely unexplored in relation to effects on children as they age and enter the workforce themselves. Accordingly, this dissertation investigated the intergenerational effects of decent work, extending beyond the immediate …

Exploring Equity In Introductory Biology Genetics Education, Sandy G. Phillips-Long

All Dissertations

The dissertation “Exploring Equity in Introductory Biology Genetics Education” delved into the critical examination of equity within undergraduate genetics education. Chapter One outlined the background, significance, research framework, and manuscripts included in this study. Chapter Two was a scoping review that provided an overview of the current pedagogical approaches in undergraduate genetics education. It identified six active learning pedagogies: Course-based Undergraduate Research Experience (CURE); group work; case-based learning; inquiry-based learning; Virtual Reality (VR); and Consider, Read, Elucidate the hypothesis, Analyze and interpret the data, and Think of the next Experiment (CREATE). Chapter Three was a systematic literature review investigating pedagogical …

The Development Of A Novel Cartilage Analog Scaffold For Chondral Regeneration, Vishal Thomas

All Dissertations

Focal Chondral Defects (FCDs) are cartilage injuries that affect about 900,000 Americans every year. Left untreated, these may lead to osteoarthritis and eventually necessitate painful knee replacements. Current treatment options are limited in terms of durability, cost, and availability of grafts. Tissue engineering, using natural scaffolds, are a highly attractive alternative promising cost efficiency, abundance, and long-term benefits. However, their low mechanical strength and dense matrices are impediments that could lead to sub-optimal repair.

In this work, a natural biomaterial, the bovine nucleus pulposus (bNP), derived from intervertebral disc tissue, was identified as a candidate scaffold for cartilage regeneration. Mechanical …

Evaluating The Use Of The Braden Scale For Predicting Pressure Sore Risk© In Residents Of A Short-Term Rehabilitation Facility, Amelia Simmons

All Dissertations

Background: Pressure injuries are significant health issues and one of the biggest challenges organizations face on a day-to-day basis. Aside from the high cost of treatment, pressure injuries also have a great impact on patients’ lives and on the provider’s ability to render appropriate care to patients The keys to preventing the development of pressure ulcers is to identify at-risk individuals as soon as possible so that measures can be implemented.

Objective: To evaluate use of the Braden Scale© on admission and weekly for three weeks in residents admitted to a short-term rehabilitation facility for two months immediately following a …

Estimation Of Some Biochemical Markers In Acute Myeloid Leukemic Patients Before And After Chemotherapy, Ayinda Mariwan Mohsen, Zeyan Abdullah Ali

Baghdad Science Journal

The aim of this study was to measure the levels of malondialdehyde (MDA), peroxynitrite (PN), homocysteine (HCY), and uric acid (UA) in acute myeloid leukemic patients (AML) (before and after taking chemotherapy) and compare results with a healthy control group. The present study includes 120 age ranged 18-70 years old suffered from AML as well as 40 healthy group. Subjects were collected from patients and a control group at Erbil’s Nanakali Hospital, they were classified into four groups: Group 1 (G1) which includes 40 healthy subjects, Group 2 (G2) includes 40 AML patients before taking chemotherapy (newly diagnosed cases), Group …

Grhpr Gene Variations In Iraqi Patients Infected With Calcium Oxalate Kidney Stones, Duha Abed Almuhssen Muzahim Alzubaidy, Luma Hassan Alwan Al Obaidy

Baghdad Science Journal

The alterations in glyoxylate reductase and hydroxy-pyruvate reductase concentrations in the sera and the genetic alterations associated with calcium oxalate kidney stones in Iraqi patients were not studied previously so this study aimed to focus on these points. This study included 80 subjects; they were 50 patients with calcium oxalate stones compared to 30 apparently healthy controls. Biochemical investigations for kidney functions (creatinine, urea, and uric acid), were performed on the sera of both groups. Also, complete blood count, random blood sugar, and blood group tests. Furthermore, urine had been collected for General Urine Examination to visualize oxalate crystals in …

August 2024, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

National Immunization Awareness Month

Each year, thousands of adults in the United States get sick from diseases that could have been prevented by vaccines.

Diet Modification Reduces Pain And Improves Function In Adults With Osteoarthritis: A Systematic Review, Karen Stanfar, Corey Hawes, Mina Ghajar, Laura Byham-Gray, Diane R. Radler

Health & Biomedical Sciences Faculty Publications

Background

The effect of dietary modifications on pain and joint function in adults with osteoarthritis (OA) is an emerging area of study. This systematic review aimed to evaluate if adults with OA who consume diets with a higher proportion of plant phenols and omega-3 fatty acids would have less pain and improved joint function than those with a higher proportion of saturated fatty acids, omega-6 fatty acids and refined carbohydrates.

Methods

Database searches of CINAHL (EBSCO), Clinical Trials (NIH-NLM), Cochrane Library (Wiley), Dissertation & Thesis Global (ProQuest), Embase (Elsevier), Medline (OVID), PubMed (NLM), Scopus (Elsevier), Web of Sciences (Clarivate) for …

Genetic Variance Present In Toll-Like Receptor 2 Of Gopherus Polyphemus, Hannah Varghese

Harriet L Wilkes Honors College Theses 2020 - Present

Gopher tortoises (Gopherus polyphemus), a keystone species of the Abacoa Greenway Preserve, face many health risks, like Upper Respiratory Tract Disease (URTD), caused by Mycoplasma agassizii infection. While URTD’s effects differ among tortoise populations, Abacoa’s tortoises display lower fatality rates with unclear causes. This study explores genetic variance in Toll-like Receptor 2 (TLR2) as a possible contributor to lower fatality rates from URTD infection. TLR2 initiates the immune response to Gram-positive bacteria in other tortoise species but is not currently sequenced in Gopherus polyphemus. Genetic sequencing targeted TLR2 through blood genomic DNA extraction, PCR fragment amplification with newly designed primers, …

Effect Of Semaglutide On Regression And Progression Of Glycemia In People With Overweight Or Obesity But Without Diabetes In The Select Trial, Steven E Kahn, John E Deanfield, Ole Kleist Jeppesen, Scott S Emerson, Trine Welløv Boesgaard, Helen M Colhoun, Robert F Kushner, Ildiko Lingvay, Bartolome Burguera, Grzegorz Gajos, Deborah Bade Horn, Irene M Hramiak, Ania M Jastreboff, Alexander Kokkinos, Michael Maeng, Ana Laura S A Matos, Francisco J Tinahones, A Michael Lincoff, Donna H Ryan, Select Trial Investigators

Faculty, Staff and Student Publications

OBJECTIVE: To determine whether semaglutide slows progression of glycemia in people with cardiovascular disease and overweight or obesity but without diabetes.

RESEARCH DESIGN AND METHODS: In a multicenter, double-blind trial, participants aged ≥45 years, with BMI ≥27 kg/m2, and with preexisting cardiovascular disease but without diabetes (HbA1c

RESULTS: Of 17,604 participants, 8,803 were assigned to semaglutide and 8,801 to placebo. Mean ± SD intervention exposure was 152 ± 56 weeks and follow-up 176 ± 40 weeks. In both treatment arms mean nadir HbA1c for participants was at 20 weeks. Thereafter, HbA1c increased similarly in both arms, with a mean difference …

Assessing The State Of Obesity Care: Quality, Access, Guidelines, And Standards, Lee M Kaplan, Caroline M Apovian, Jamy D Ard, David B Allison, Louis J Aronne, Rachel L Batterham, Luca Busetto, Dror Dicker, Deborah B Horn, Aaron S Kelly, Jeffrey I Mechanick, Jonathan Q Purnell, Ximena Ramos-Salas, Assessing The State Of Obesity Care Writing Group

Faculty, Staff and Student Publications

BACKGROUND: An international panel of obesity medicine experts from multiple professional organizations examined patterns of obesity care and current obesity treatment guidelines to identify areas requiring updating in response to emerging science and clinical evidence.

AIMS: The panel focused on multiple medical health and societal issues influencing effective treatment of obesity and identified several unmet needs in the definition, assessment, and care of obesity.

METHODS: The panel was held in Leesburg, Virginia in September 2019.

RESULTS: The panelists recommended addressing these unmet needs in obesity medicine through research, education, evaluation of delivery and payment of care, and updating clinical practice …

Assessment Of Gfr In Patients With Cancer: A Statement From The American Society Of Onco-Nephrology, Abhijat Kitchlu, Verônica T Costa E Silva, Shuchi Anand, Jaya Kala, Ala Abudayyeh, Lesley A Inker, Mitchell H Rosner, Sabine Karam, Prakash Gudsoorkar, Shruti Gupta, Sheldon Chen, Nattawat Klomjit, Nelson Leung, Tomaz Milanez, Shveta S Motwani, Sheikh B Khalid, Vinay Srinivasan, Rimda Wanchoo, Jan H Beumer, Geoffrey Liu, Nizar M Tannir, Ani Orchanian-Cheff, Yimin Geng, Sandra M Herrmann

Faculty, Staff and Student Publications

Accurate assessment of GFR is crucial to guiding drug eligibility, dosing of systemic therapy, and minimizing the risks of both undertreatment and toxicity in patients with cancer. Up to 32% of patients with cancer have baseline CKD, and both malignancy and treatment may cause kidney injury and subsequent CKD. To date, there has been lack of guidance to standardize approaches to GFR estimation in the cancer population. In this two-part statement from the American Society of Onco-Nephrology, we present key messages for estimation of GFR in patients with cancer, including the choice of GFR estimating equation, use of race and …

Quantifying Relationships In Fuzzy Cognitive Maps Based On Content Analysis Of Unstructured Research Texts, Ahmed Alibage, Antonie J. Jetter, Elpiniki Papageorgiou

Engineering and Technology Management Faculty Publications and Presentations

FCM projects often rely on knowledge-based approaches, such as expert interviews, which can be challenging to conduct because they require extensive expert participation. We propose a novel alternative to create FCM models based on expert knowledge that is already codified in research texts and other publications. In this approach, thematic network analysis identifies FCM concepts and signed causal connections, while computation of t-coefficient is used to determine the weights of the identified edges. We introduce and evaluate the approach in the context of a real-world system modeling project that is based on 47 carefully selected, peer reviewed research publications on …

Assessing Sarcopenia In Advanced-Stage Ovarian Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Case Series, Christelle Schofield, Dennis R. Taaffe, Robert U. Newton, Daniel A. Galvão, Paul A. Cohen, Jin Soo Kim, Tarek Meniawy, Carolyn Peddle-Mcintyre

Research outputs 2022 to 2026

Objectives: In ovarian and other cancers, low muscle mass and density are associated with poorer clinical outcomes. However, screening for cancer-related sarcopenia (typically defined as low muscle mass) is not routinely conducted. The European Working Group on Sarcopenia in Older People (EWGSOP) recommends an algorithm for sarcopenia screening and diagnosis in clinical settings, with sarcopenia based on muscle strength and mass, and severity on physical performance. We explored the application of the EWGSOP2 algorithm to assess sarcopenia in six ovarian cancer patients receiving neoadjuvant chemotherapy. Methods: We assessed sarcopenia risk with the SARC-F screening questionnaire (at risk ≥4 points), muscle …

Fatigue Performance Of 3d-Printed Poly-Lactic-Acid Bone Scaffolds With Triply Periodic Minimal Surface And Voronoi Pore Structures, Hamed Bakhtiari, Alireza Nouri, Majid Tolouei-Rad

Research outputs 2022 to 2026

Bone scaffolds serve a crucial role in tissue engineering, particularly in facilitating bone regeneration where natural repair is insufficient. Despite advancements in the fabrication of polymeric bone scaffolds, the challenge remains to optimize their mechanical resilience. Specifically, research on the fatigue behaviour of polymeric bone scaffolds is scarce. This study investigates the influence of pore architecture on the mechanical performance of poly-lactic-acid (PLA) scaffolds under quasi-static and cyclic compression. PLA scaffolds with a 60% porosity were fabricated using extrusion-based 3D printing in various designs: Gyroid, Lidinoid, Fischer–Koch, IWP, and Voronoi. Results demonstrated that Gyroid scaffolds had the highest compressive strength …

Apolipoprotein Ε4 Is Associated With Increased Risk Of Fall- And Fracture-Related Hospitalization: The Perth Longitudinal Study Of Ageing Women, Jedd Pratt, Jack Dalla Via, Craig Sale, Abadi K. Gebre, Blossom C.M. Stephan, Simon Laws, Kun Zhu, Wai H. Lim, Richard L. Prince, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Apolipoprotein ε4 (APOE ε4) may be a genetic risk factor for reduced bone mineral density (BMD) and muscle function, which could have implications for fall and fracture risk. We examined the association between APOE ε4 status and long-term fall- and fracture-related hospitalization risk in older women. A total of 1 276 community-dwelling women from the Perth Longitudinal Study of Aging Women (mean age ± SD = 75.2 ± 2.7 years) were included. At baseline, women underwent APOE genotyping and detailed phenotyping for covariates including prevalent falls and fractures, as well as health and lifestyle factors. The association between APOE ε4 …

Blood, Sweat, And Tears: Implications For Hydration Testing In Combat Sports—Investigating Body Mass Loss And Biomarker Changes, Colin S. Doherty, Lauren V. Fortington, Oliver R. Barley

Research outputs 2022 to 2026

Combat sports athletes often undergo rapid body mass loss (BML), which presents health risks. Hydration testing has been proposed as a possible solution to reduce or eliminate rapid BML. However, combat sports athletes may exhibit distinct physiological characteristics due to repeated exposure to BML. Thus, traditional and emerging hydration biomarkers should be investigated to determine their potential suitability for field use in this cohort. This study examined whether BML can explain changes in serum and urine osmolality (SosmΔ, UosmΔ), tear osmolarity (TosmΔ), hematocrit (HctΔ), and urine-specific gravity (USGΔ) after mild–moderate passive dehydration. Biomarker reliability was also assessed across two trials. …