Digital Commons Network^™

An Obligatory Role For Agrp Neurons In Maintaining Body Temperature During Time-Restricted Feeding, Cunjin Su, Jing Cai, Yuanzhong Xu, Benjamin R Arenkiel, Qingchun Tong

The Brown Foundation: Institute of Molecular Medicine

Homeotherms maintain a steady body temperature through thermoregulation, a process critical for survival during fasting, in which the brain has to defend energy-costly body temperature while reducing energy expenditure to conserve energy reserve; however, the neural basis for defending body temperature remains unclear. Here, we demonstrated that AgRP neuron lesion led to lethality during time-restricted feeding on chow but not on HFD, and caused no obvious impact on HFD-induced obesity or obesity-reducing responses to glucagon-like peptide-1 receptor agonism. The lesion disrupted adaptive feeding behaviors during time-restricted feeding and reduced motivational feeding on chow. Notably, the lethality was caused by hypothermia …

Essays On Health And Immigration Policy, Selen Ozdogan

Dissertations, Theses, and Capstone Projects

This dissertation consists of two essays in applied microeconomics, each examining how individuals and institutions respond to policy changes. Both essays leverage natural experiments and recent advances in difference-in-differences estimation to identify causal effects. Both also speak to a common theme in public policy: the gap between intended and actual consequences of government intervention, and the role that policy design plays in shaping those consequences.

The first essay examines the impact of state-level e-cigarette excise taxes on nicotine and tobacco exposure among adults aged 18 and older. A central contribution is its use of individual-level panel biomarker data from urine …

Gathering Knowledge, Sustaining Science: The Female Forager And American Mushroom Culture, 1880–1930, Madeline S. Dede-Panken

Dissertations, Theses, and Capstone Projects

Unearthing origins of modern mycophilia, this dissertation explores the mushroom mania which reverberated through American society at the turn of the twentieth century, empowering Anglo-American women in new ways. America’s largely forgotten first mushroom fad illuminates gendered negotiations of foraging culture and public science. Beginning in the 1880s, a remarkable cohort of women helped turn mushrooms from shunned, mysterious organisms into wholesome delicacies for culinary and intellectual enrichment. Female enthusiasts fostered a vibrant mushroom culture and nationwide network of mycophiles. Culinary applications and poisoning fears legitimized women’s presence in scientific endeavors, positioning mycology as vital female knowledge for public safety …

Memoir Of A Fruitfly, Arjun Ramanthan

Intertidal

No abstract provided.

Microbial Literacy, Equity, And Sustainability At Cal Poly: A Policy Framework With University Housing As A Pilot Case, Joseph B. Fewel

Biological Sciences

Microorganisms play a fundamental role in human health, environmental systems, and the functioning of built environments, yet they remain largely absent from sustainability and public policy discussions. This project proposes a framework for integrating microbial literacy, equity, and health into institutional decision-making, using California Polytechnic State University (Cal Poly) as a case study and university housing as a pilot site for implementation. Drawing on interdisciplinary literature in microbiology, public health, environmental justice, and sustainability, as well as policy analysis and stakeholder interviews, this project examines how campus systems, including housing, ventilation, sanitation, food systems, and waste management, shape microbial exposure …

Exploring Psychosocial Risk Factors For Disordered Eating Among Future Healthcare Professionals: A Cross-Sectional Analysis, Ayron Walker, Manan Roy, Jenna Warnock, Karlee Prater, Alisha Farris, Danielle Nunnery

Appalachian Student Healthcare Research Review

Background. The prevalence of disordered eating (DE) patterns is significantly higher among college-aged students and health-related majors. This study explored associations between DE behaviors and psychosocial risk factors, including adverse childhood experiences (ACEs), food insecurity, weight stigma, fat phobia, and family ‘fat talk’, among health science students at a large, rural U.S university, using an anonymous online survey.

Method. An anonymous online survey was distributed to a randomly selected, cross-sectional sample of 3,000 health science students. Participant responses (n = 550; 18.3% response rate) were analyzed using Pearson’s correlation, and multiple linear regression.

Results. The sample was …

Intouch Week Of June 1, 2026, New York Medical College

InTouch

• Annual NYMC Golf Tournament Recognizes Excellence in Leadership and Service
• NYMC Announces 2026-2027 Translational Science Initiative Recipients
• Suicidality Is Key Predictor of Treatment-Resistant Focal Epilepsy
• TCDM Celebrates Class of 2026 Commencement
• Top It Off: 20% Off Select Hats
• Student Spotlight: Inspired to Innovate, Driven to Heal 
• Alumni Spotlight: A Passion for Performing Arts and Physical Therapy
• Alumni Spotlight: Two Lives in One Career

Assessing Rural Homelessness: A Mixed-Methods Case Study, Matthew Lyons, Ashley Feierstein, Christy Storey, Akilah Hairston, Jonathan Jones, Jada Brown, Sarah H. Cross

Journal of Rural Social Sciences

Rural homelessness represents a significant public health and human rights challenge, but research on homelessness in the United States has predominantly focused on urban settings. This case study describes a mixed-methods assessment of the prevalence, causes, and consequences of homelessness in a rural county. Through both surveys and interviews with stakeholders from multiple sectors (including both service providers and those experiencing homelessness), we built a rich picture of the scale and experiential dimensions of homelessness within the county. Here, we present our research methods, the main findings of each primary data collection arm, and the actionable conclusions drawn from the …

Co-Designed Interventions Package For Enhancing Women's Resilience In Reproductive And Child Health Through Income-Generating Associations: A Human-Centered Design Study In Tanzania, Kahabi Isangula, Aminieli Itaeli Usiri, Eunice Pallangyo

School of Nursing & Midwifery, East Africa

Background: Maternal and under-five mortality remain major public health concerns in many low- and middle-income countries, including Tanzania. Despite their widespread use in strengthening economic resilience, income-generating associations (IGAs) have not fully utilized their potential as platforms for addressing reproductive and child health (RCH) challenges.

Objective: This study aimed to co-design an intervention package with women participating in income-generating associations to enhance their preparedness and resilience in addressing RCH challenges in Tanzania.

Methods: A qualitative descriptive study guided by a Human-Centered Design (HCD) framework was conducted in the Arusha and Shinyanga regions of Tanzania. The study followed …

Ecological Support For Stem International Doctoral Student Success, Emily A. Crider

Journal of Comparative & International Higher Education

International doctoral students enrich U.S. institutions but often encounter challenges that affect belonging and academic success. This qualitative study examined the social, cultural, and institutional challenges faced by international STEM doctoral students and the role of faculty advisor relationships in their adaptation. Guided by ecological systems theory, interviews with eight participants revealed five major challenges: language barriers, cultural differences, building social networks, financial challenges, and navigating institutional processes. Positive faculty mentorship was critical, with effective advisors demonstrating empathy, adaptability, responsiveness, guidance, and trust while supporting professional development, funding, and networking. Microsystem and mesosystem interactions were most influential. Findings emphasize the …

Skip The Grid: Installing Solar Systems In The Navajo Nation, Joey Massey

Construction Management

Skip the Grid is a student led interdisciplinary project that aims to bring sustainable solar energy to families in the Navajo Nation who lack reliable power at home. The 2026 Skip the Grid trip was the fifth consecutive year of the joint effort between California Polytechnic State University (Cal Poly) students across multiple departments, Heart of America (HOA), SOLV Energy, and Nextpower. Over the three working days the 5 teams installed Goal Zero Solar Systems in 50 homes on both the Navajo Nation and Hopi Reservation. These systems brough power, light, and refrigeration to families, enhancing their quality of life …

Westside Foodshed Hub Initiative: Farm-To-Food-Assistance Feasibility Study, Andrew Bugh, James Shelstad, Jordan Rasmussen, Kenton Marquigny, Reed Johnson

Master of Urban and Regional Planning Workshop Projects

The Westside Foodshed Planning Initiative is a feasibility study exploring how Farm-to- Food-Assistance, or F2FA, can supplement CAFE's food assistance work in Northwest and Downtown Portland. The study was conducted by Soil for Roses, a planning team consisting of members of Portland State University's Master of Urban and Regional Planning program. Through this project, Soil for Roses envisions the F2FA as a regional food aggregation and distribution hub tailored to CAFE’s goals of advancing food security and nutrition, environmental stewardship, and resilience.

A Qualitative And Quantitative Comparative Analysis Of Ballistic Bone Trauma From Frangible And Full Metal Jacket Projectiles, Hajar S. Hassan

Student Theses

Ballistic bone research is essential as 90% of homicides with the use of a firearm include injuries to bone. Forensic anthropologists use ballistic bone trauma to gather details and reconstruct an event, but ballistic bone trauma depends on many intrinsic and extrinsic factors. These factors include the type of bone, the type of firearm, and the type of ammunition. As new ammunition and firearms emerge, the literature on ballistic bone trauma remains limited. This novel study compares the bone trauma from the most common projectile, the full metal jacket, to a frangible projectile which is made to break upon impact. …

Enhancing Soil Security In Brazilian Cerrado: Composted Sewage Sludge As A Sustainable Conservation Agriculture Strategy, Raimunda Eliane Nascimento Do Nascimento, Nathércia Castro Elias, Philippe Solano Toledo Silva, Rodrigo Silva Alves, Aline Renée Coscione, Jussara Borges Regitano, Wanderley José, Cassio Hamilton Abreu-Junior, Gian Franco Capra, Arun Dilipkumar Jani, Thiago Assis Rodrigues Nogueira

Biology, Agriculture and Chemistry Faculty Publications and Presentations

Oxisols in the Brazilian Cerrado are intensively cultivated due to their strategic importance in producing a range of commodities exported worldwide. To achieve high productivity, a large amount of conventional mineral fertilizer (CMF) must be used, which raises multiple concerns. Composted sewage sludge (CSS) is a promising organic fertilizer that enhances soil health while increasing agricultural sustainability. The objective of this study was to monitor soil chemical quality at two depths (0–0.1 m and 0.1–0.2 m) after CSS applications over three agricultural years under a no-tillage system. The experiment was conducted under field conditions by applying and evaluating five rates …

Exploring Capacity For Future Sustainability Of Healthy Eating Policy, Systems, And Environmental Change Strategies Previously Implemented Through Snap-Ed Programming, Carrie L. Draper, Nicholas Younginer Ph.D.

Faculty Publications

Objective

Design

Setting

Participants

Phenomenon of Interest

Analysis

Results

Soybean Plant Population Density Recommendations Across The United States, Giovani Preza Fontes, Carrie Ortel, Emma Macham, David Moseley, Shawn Conley, Chad Lee, Mark A. Licht, Laura E. Lindsey, Haleigh J. Ortmeier-Clarke, Rachel Vann, Maninder P. Singh, Seth Naeve, Jeremy Ross, Jake Mcneal, Michael Plumblee, Shaun Casteel, Eros Francisco, Michael J. Mulvaney, Nicolas Cafaro La Menza, Andre Froes De Borja Reis, Daniela Carrijo, Emerson Nafziger

Plant and Soil Sciences Faculty Publications

Rising production costs and declining commodity prices have compelled farmers to reassess their input and management strategies. Soybean [Glycine max (L.) Merr] seed costs, in particular, have continued to increase due to advances in biotechnology, higher-yielding germplasm, and available seed treatments, accounting for 32–35% of the total operational expenses in current soybean production systems. Optimizing seeding rate is therefore one area of consideration for improving profitability and maximizing return on investment. However, soybean yield response to plant population density is influenced by the combination of several factors, including water availability, temperature, radiation interception, planting practices, and crop growth and development. …

Practice With Purpose Policy Project: The Pediatric Ng/Og Tube Safety Hierarchy, Caitlin Roush, Christine Hajovsky, Delaney Dewolf, Elizabeth Hernandez, Giselle Daclan, Jay Barber, Kris Noel, Kristen Dickey, Lynde Craig, Madeline Herrera, Margaret Willenburg, Mckenzie Pedigo, Melynda Olguin, Myesha Vines, Rhianna Brard, Teresa Wynee

Practice With Purpose

No abstract provided.

Cardioprotective Effects Of 1,3 Butanediol In Masld Via Reversal Of Cardiac Lipid Accumulation And Suppression Of Cardiac Fibrosis, Olufunto O. Badmus, Landon D. Parrow, Karis E. Mcgowen, La Brenda Bell, Jennifer R. Greer, Marcela De Carvalho Cruz, Terry D. Hinds, David E. Stec

Markey Cancer Center Faculty Publications

Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly associated with the development of cardiovascular disease (CVD); however, the mechanisms responsible are currently unknown. We have developed a model of MASLD due to the loss of hepatocyte peroxisome proliferator-activated receptor α (PPARα^HEPKO). We found that plasma beta-hydroxybutyrate (BHOB) levels were significantly reduced in PPARα^HEPKO mice and aimed to investigate the therapeutic potential of restoring BHOB levels in the development of CVD in these mice. Thirty-week-old PPARα^HEPKO and control PPARα^FL/FL mice were randomized to receive 1,3 butanediol (1,3-BDO), a precursor of BHOB, in drinking water for 6 …

Antioxidant Therapy Reverses Hepatotoxicity Induced By Microcystin-Lr In A Cellular Model Of Metabolic Dysfunction-Associated Steatotic Liver Disease (Masld), Apurva Lad, Jason Kindle, Prajwal Hegde, Gabriel G. Kleer, Andrew L. Kleinhenz, Johnna A. Birbeck, Judy Westrick, Nicholas J. Peraino, Terry D. Hinds, Neeraja Purandare, Andrew M. Fribley, Steven T. Haller, David J. Kennedy

Markey Cancer Center Faculty Publications

Microcystin-LR (MC-LR) is a potent hepatotoxin that has been shown to cause liver damage even at doses lower than the established Low Observable Adverse Effect Level (LOAEL) of 200 μg/kg in animal models. We have previously observed that low-dose exposure to MC-LR in animals with diet-induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and subsequent treatment with antioxidants like N-acetylcysteine (NAC) and the Na⁺/K⁺ ATPase-Src kinase inhibitor pNaKtide significantly alleviated hepatic infiltration of immune cells, downregulated markers of inflammation and hepatotoxicity, increased the breakdown of the toxin molecule, and restored phase I and II drug metabolism pathways, including …

GαQ Is A Heterotrimeric G-Protein Subunit That Directs The Selectivity Of Pparγ-Induced Gene Pathways Toward Energy-Related Processes Rather Than Adiposity, Evelyn A. Bates, Zachary A. Kipp, Wang Hsin Lee, Genesee J. Martinez, Sally N. Pauss, Philipp E. Scherer, Terry D. Hinds

Markey Cancer Center Faculty Publications

Background/Objectives: Signaling mediators of PPARγ influence pathways involved in adipogenesis, lipid storage, inflammation, energy-related processes, and glucose utilization. Recent research indicates that PPARγ coregulators, recruited or released during ligand binding, govern specific gene pathways. It was recently discovered that Gα_q, a heterotrimeric G protein subunit, also signals to PPARγ and may significantly affect adipogenesis and glucose sensitivity. Methods: To explore Gα_q’s role in adipocytes, we generated CRISPR-mediated Gα_q (Gnaq) knockout (Gnaq KO) and scramble control cells from 3T3-L1 preadipocytes. Results: The absence of Gα_q resulted in increased lipid accumulation and elevated serine 273 (but …

Understanding The Role Of Age And U.S. Acculturation Factors On The Relationship Between Allostatic Load And Cancer Mortality Risk In Hispanic Americans, Jessica Amezcua, Valeria Miranda, Melissa Lopez-Pentecost, Jessica Y. Islam, Marlo M. Vernon, Kathleen O’Connor, Justin Xavier Moore

Markey Cancer Center Faculty Publications

Purpose: Despite growing recognition of stress-related health inequities, the role of nativity and acculturation in shaping the relationship between chronic stress and cancer outcomes among Hispanic populations remains poorly understood. The purpose of this study was to examine whether nativity factors (United States (US) citizenship status and length of time residing in the US modify the association between allostatic load (AL), a measure of chronic physiologic stress, and cancer mortality among Hispanic adults. Methods: We performed a prospective cohort analysis using data from the National Health and Nutrition Examination Survey (NHANES) 1999 – 2010, linked to National Death Index with …

Structured Telehealth Community Health Worker-Clinician Feedback And Diabetes Outcomes: A Randomized Clinical Trial, Elizabeth Vaughan, Xiaoying Yu, Amber Amspoker, Aanand Naik, Ashok Balasubramanyam, Craig Johnston, Christi Ballantyne, Salim S. Virani, Shelton Brown, Kristina Mena

Population Health, East Africa

Importance  Community health workers (CHWs) improve chronic disease management in underserved populations, but scalable integration strategies are limited.

Objective  To evaluate whether a multidimensional intervention incorporating telementored CHWs and a structured participant-CHW-clinician feedback loop can improve diabetes outcomes.

Design, Setting, and Participants  This 12-month randomized clinical trial was conducted at 3 institutionally and geographically diverse community clinics in Texas between September 1, 2023, and April 30, 2025, and included low-income, uninsured White Hispanic adults with type 2 diabetes identified through clinic databases. Data were analyzed between May 1 and July 31, 2025.

Intervention  Individuals were randomized 1:1 to the intervention …

An Analysis Of Public Library Services For The Tribal Community In Rayalaseema Region With A Special Reference To Healthcare And Hygiene, P Ramu Naik Mr, V. K. Dhanyasree Dr

Library Philosophy and Practice (e-journal)

Public libraries have long been recognised as critical societal institutions, serving as information, education, and community engagement centres. In the context of tribal communities, their role in disseminating health information is particularly significant. Tribal populations often face unique health challenges and disparities, making access to accurate and reliable health information vital to their well-being. This study examines the pivotal role that public libraries play in disseminating health information to tribal people. The study is conducted among 13 branch libraries in the tribal areas of Rayalaseema region. A structured questionnaire was used for the survey. The results show that even though …

Advancing Telehealth Pulmonary Rehabilitation For Individuals With Copd: Integrating Scoping Review, Quantitative, And Qualitative Studies To Inform A Multidomain Telewellness Framework, Pooja Arora

ETDs from 2020-2029

Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous, progressive respiratory condition and the third leading cause of death worldwide. It is associated with dyspnea, reduced exercise tolerance, significant psychological burden, and poor quality of life. Telehealth pulmonary rehabilitation (PR) has evolved as an effective approach to improve health outcomes and overcome barriers related to center based pulmonary rehabilitation. However, it is important to determine whether these programs are guided by intervention frameworks that effectively promote overall well-being in individuals with COPD. This dissertation examined current telehealth PR models and evaluated the effectiveness of a generic, comprehensive telewellness program (MENTOR: …

Volume 41, Issue 1, Full Issue, Journal Of Rural Social Sciences

Journal of Rural Social Sciences

No abstract provided.

Effects Of Led Light Spectra And 1-Mcp On Postharvest Quality And Bioactive Compounds Of Cucumber (Cucumis Sativus L.) During Cold Storage, Imad Eldin Abbas Yousif

Theses

Extending postharvest quality and maintaining the nutritional value of cucumber fruit requires specific storage conditions to postpone senescence and enhance marketability. The postharvest lighting environment is a main factor that influences quality preservation for harvested biomass. The objective of this study was to investigate the effects of different light emitting diodes (LED) spectra (green, red, blue, and white LED) alone or in combination with 1-Methylcyclopropene (1-MCP) on postharvest quality and bioactive compounds of cucumber fruit during cold storage for 16 days at 5°C, the control fruit were left in the dark. For combined treatment, the fruits were exposed to 1-MCP …

Protective Potential Of Minimally Processed, Plant-Derived Foods Against Steatotic Liver Disease In Early Adulthood, Yasmina Tashkent, Jocelyn M. Choo, Steven L. Taylor, Therese A. O'Sullivan, Dujinthan Jayabalan, Sophie J. Miller, Richard Woodman, Luis Calzadilla-Bertot, Oyekoya T. Ayonrinde, Lawrence J. Beilin, Trevor A. Mori, John K. Olynyk, Alan J. Wigg, Kate R. Muller, Leon A. Adams, Geraint B. Rogers

Research outputs 2022 to 2026

Background & aims: The incidence of steatotic liver disease (SLD) among younger adults is increasing globally. While poor diet is a recognised risk factor, the impact of specific dietary components is unclear. We investigated associations between dietary patterns and SLD markers in younger adults. Methods: Analysis involved 887 members of the Raine Study Generation 2 cohort, assessed at age 27. SLD was defined using a validated MRI volumetric liver fat fraction equation. Dietary intake, assessed by food frequency questionnaires, was summarised using a modified Overall Diet Score (ODS) that classified foods as “healthy” or “unhealthy.” Associations between diet and SLD …

Precision Nutrition In Breast Cancer: Towards Patient- And Tumour-Informed Dietary Strategies, Cristina Crespo-García, R. Taaffe, Carolyn Peddle-Mcintyre, Emily Jeffery, John P. Campbell, Robert Thomas, Daniel A. Galvao, Robert U. Newton

Research outputs 2022 to 2026

Dietary strategies are increasingly recognized as important modulators of breast cancer outcomes, acting through effects on metabolic regulation, weight management, hormone signalling, immune function, and the gut microbiome. However, breast cancer heterogeneity and inter-individual variability mean that generic dietary guidelines may not fully capture patient needs. Precision nutrition offers the opportunity to align dietary interventions with tumour subtype, treatment context, and host biology, potentially enhancing therapeutic response and survivorship in patients diagnosed with breast cancer. In this narrative review, we summarize evidence on dietary patterns and prognosis, and explore how targeted interventions, including fasting regimens, ketogenic diets, and caloric restriction, …

A Qualitative Exploration Of Unanticipated Effects Experienced By People With Chronic Obstructive Pulmonary Disease Who Participated In Interventions Designed To Reduce Sedentary Behaviour, Fiona Coll, Vinicius Cavalheri, Daniel F. Gucciardi, Kylie Hill

Research outputs 2022 to 2026

Introduction: This study explored the lived experiences of people with chronic obstructive pulmonary disease (COPD) who participated in interventions designed to reduce the accumulation of sedentary behaviour in prolonged uninterrupted bouts. Methods: Ten participants with stable COPD participated in a multi-component intervention that spanned over 9 months and was designed to address the intervention message ‘If you have been sitting or resting continuously for 30 min, stand up and move’. Interventions comprised participation in an 8-week programme of supervised exercise training coupled with behaviour change techniques. Throughout the intervention period the person delivering the intervention kept detailed notes of their …

Rode: Linear Rectified Mixture Of Diverse Experts For Food Large Multi-Modal Models, Pengkun Jiao, Xinlan Wu, Bin Zhu, Jingjing Chen, Chong-Wah Ngo, Yu-Gang

Research Collection School Of Computing and Information Systems

Large Multi-modal Models (LMMs) have significantly advanced a variety of vision-language tasks. The scalability and availability of high-quality training data play a pivotal role in the success of LMMs. In the realm of food, while comprehensive food datasets such as Recipe1M offer an abundance of ingredient and recipe information, they often fall short of providing ample data for nutritional analysis. The Recipe1M+ dataset, despite offering a subset for nutritional evaluation, is limited in the scale and accuracy of nutrition information. To bridge this gap, we introduce Uni-Food, a unified food dataset that comprises over 100,000 images with various food labels, …