Digital Commons Network^™

Implementing A Nurse-Enabled, Integrated, Shared-Care Model Involving Specialists And General Practitioners In Early Breast Cancer Post-Treatment Follow-Up (Eminent): A Single-Centre, Open-Label, Phase 2, Parallel-Group, Pilot, Randomised, Controlled Trial, Raymond J. Chan, Fiona Crawford-Williams, Chad Yixian Han, Lee Jones, Alexandre Chan, Daniel Mckavanagh, Marissa Ryan, Christine Carrington, Rebecca L. Packer, Megan Crichton, Nicolas H. Hart, Emma Mckinnell, Melissa Gosper, Juanita Ryan, Bethany Crowe, Ria Joseph, Carolyn Ee, Jane Lee, Steven M. Mcphail, Katharine Cuff, Laisa Teleni, Jon Emery

Research outputs 2022 to 2026

Background: Current models of post-treatment cancer care rely heavily on hospital-based, medical specialists and do not sufficiently leverage primary care. Many breast cancer survivors face ongoing unmet needs that may benefit from a multidisciplinary, shared-care approach. We aimed to evaluate the feasibility and preliminary effectiveness of implementing nurse-enabled, shared-follow-up care between the acute and primary care setting for early-stage breast cancer. Methods: In this single-centre, open-label, phase II, pilot, randomised, controlled trial, individuals diagnosed with breast cancer (Stage 0–III) were randomised 1:1 to either usual care or intervention, which includes a 1) Specialist Nurse Consultation to co-develop a survivorship care …

Weight Loss, Nutritional Aspects And Quality Of Life In Head And Neck Cancer Survivors, Alessandro Villa

All Publications

Objectives: Comprehensive care is fundamental to cancer survivors enduring long-term side-effects of cancer treatment including nutrition impact symptoms and critical weight loss (CWL). The aim of our study was to address weight loss (WL), nutritional aspects, and quality of life (QoL) in head and neck cancer (HNC) survivors.

Study design: This was a cross-sectional study of HNC patients treated at the Sapienza University-Hospital, 2018-2022. We administered a modified version of the EORTC-QLQ-H&N35, the National Health and Nutrition Examination Survey for taste disorders, and the Fox Questionnaire for dry mouth. WL was recorded at T0 (before cancer treatment), T1 (right after …

Safety And Efficacy Of Dtx401, An Aav8-Mediated Liver-Directed Gene Therapy, In Adults With Glycogen Storage Disease Type I A (Gsdia), David A Weinstein, Terry G Derks, David F Rodriguez-Buritica, Ayesha Ahmad, María-Luz Couce, John J Mitchell, Rebecca Riba-Wolman, Malaya Mount, Julieta Bonvin Sallago, Katalin M Ross, Melanie M Van Der Klauw, Foekje De Boer, Caroline Van Der Schaaf, Heather Saavedra, Miguel Martínez-Olmos, Elvis Atanga, Asad Hosseini, Deepali Mitragotri, Eric Crombez

Faculty, Staff and Student Publications

Glycogen storage disease type Ia (GSDIa) is a rare, life‐threatening, inherited carbohydrate metabolism disorder caused by glucose‐6‐phosphatase (G6Pase) deficiency, which is essential for glycogenolysis and gluconeogenesis. GSDIa management includes a strict medically prescribed diet that typically includes daily uncooked cornstarch doses, including overnight, to maintain euglycemia. DTX401 is an investigational adeno‐associated virus serotype 8 vector expressing the human G6PC1 gene that encodes G6Pase. This open‐label, phase 1/2, dose‐escalation, 52‐week gene therapy trial evaluated the safety and efficacy of a single DTX401 infusion in 12 adults with GSDIa (ClinicalTrials.gov Identifier: NCT03517085). Three participants in Cohort 1 received DTX401 2.0 × …

Economic Model Of Uridine Triacetate Versus Supportive Care For The Treatment Of Patients With Life-Threatening Early-Onset Severe Toxicity, Jorge Garcia

All Publications

No abstract provided.

Safety And Antitumor Activity Of A Novel Acd25 Treg Depleter Rg6292 As A Single Agent And In Combination With Atezolizumab In Patients With Solid Tumors, Valentina Gambardella, Michael Ong, Maria E Rodriguez-Ruiz, Jean-Pascal Machiels, Miguel F Sanmamed, Vladimir Galvao, Anna Spreafico, Daniel J Renouf, Stephen J Luen, Rachel Galot, Bernard Doger De Spéville, Emiliano Calvo, Aung Naing, Samira Curdt, Theresa Maria Kolben, Eva Rossmann, Tamara Tanos, Kevin Smart, Maria Amann, Yuying Xie, Linxinyu Xu, Enrique Gomez Alcaide, Nicolas Städler, Nicole Justies, Christophe Boetsch, Vaios Karanikas, Gabriel Schnetzler, Kristoffer S Rohrberg

Faculty, Staff and Student Publications

Purpose: Therapeutic depletion of immunosuppressive regulatory T cells (Treg) may overcome resistance to cancer immunotherapies. RG6292 is an anti-CD25 antibody that preferentially depletes Tregs while preserving effector T-cell functions in preclinical models. The safety, pharmacokinetics, pharmacodynamics, and antitumor efficacy of selective Treg depletion by RG6292 administered as monotherapy or in combination with atezolizumab were evaluated in two phase I studies.

Patients and methods: Adult patients with advanced solid tumors were administered intravenous RG6292, given every 3 weeks alone (study 1: NCT04158583, n = 76) or with 1,200 mg atezolizumab every 3 weeks (study 2: NCT04642365, n = 49). …

Beyond Nutrition: Exploring Immune Proteins, Bioactive Peptides, And Allergens In Cow And Arabian Camel Milk, Manujaya W. Jayamanna Mohottige, Angéla Juhász, Mitchell G. Nye-Wood, Katherine A. Farquharson, Utpal Bose, Michelle L. Colgrave

Research outputs 2022 to 2026

Bovine milk has dominated the dairy segment, yet alternative milk sources are gaining attention due to perceived superior health benefits, with immune proteins and bioactive peptides (BPs) contributing to these benefits. Fractionation affects protein recovery and composition. Here, the cream fraction resulted in the highest yield of proteins, identifying 1143 camel and 851 cow proteins. The cream fraction contained a significantly higher concentration of immune system-related proteins. Straightforward filtration and protein precipitation methods achieved average BP detections of 170 and 177, compared to 31 by a solvent-solvent extraction method. Considering potentially allergenic proteins, 53 (camel) and 52 (cow) were identified. …

Inter-Individual Differences In The Blood Pressure Lowering Effects Of Dietary Nitrate: A Randomised Double-Blind Placebo-Controlled Replicate Crossover Trial, Eleanor Hayes, Shatha Alhulaefi, Mario Siervo, Eleanor Whyte, Rachel Kimble, Jamie Matu, Alex Griffiths, Marc Sim, Mia Burleigh, Chris Easton, Lorenzo Lolli, Greg Atkinson, John C. Mathers, Oliver M. Shannon

Research outputs 2022 to 2026

Purpose: Dietary nitrate supplementation increases nitric oxide (NO) bioavailability and reduces blood pressure (BP). Inter-individual differences in these responses are suspected but have not been investigated using robust designs, e.g., replicate crossover, and appropriate statistical models. We examined the within-individual consistency of the effects of dietary nitrate supplementation on NO biomarkers and BP, and quantified inter-individual response differences. Methods: Fifteen healthy males visited the laboratory four times. On two visits, participants consumed 140 ml nitrate-rich beetroot juice (~ 14.0mmol nitrate) and, on the other two visits, they consumed 140 ml nitrate-depleted beetroot juice (~ 0.03mmol nitrate). Plasma nitrate and nitrite …

Evaluation Of A Complex Intervention: The Latch On Randomized Controlled Trial Of Multicomponent Breastfeeding Support For Women With A Raised Body Mass Index, Catherine Mcnestry, Anna Hobbins, Niamh Donnellan, Paddy Gillespie, Fionnuala M. Mcauliffe, Sharleen L. O'Reilly, Denise Mcguinness, Sarah Louise Killeen, John Mehegan, Barbara Coughlan, Eileen C. O'Brien, Marie Conway, Denise O'Brien, Marcelina Szafranska, Mary Brosnan, Lucille Sheehy, Rosie Murtagh, Lorraine O'Hagan, Marie Corbett, Michelle Walsh, Regina Keogh, Paula Power, Marie Woodcock, Mary Phelan, Amy Carroll, Stephanie Murray, Charmaine Scallan, Elizabeth Dunn

Research Outputs: 2025-Present

Background: Latch On's objective was to achieve improved breastfeeding rates in women with raised body mass indices using a multicomponent breastfeeding support intervention. Methods: A hybrid type 1 implementation-effectiveness trial with mixed-methods process and health economics analyses were conducted. Data collection included stakeholder questionnaires, interviews, focus groups, fidelity data, participant and health system costs. Results: The intervention was delivered with fidelity but the high breastfeeding rates at 3 months were not different between intervention and usual care. Participants receiving the minimum intervention dose were more likely to initiate breastfeeding (P = 0.045) and be breastfeeding at hospital discharge (P = …

Technical Cooperation Programme To Build Countries’ Capacities For Science-Based Sustainable Marine Management, Marc Metian, Jana Friedrich, Pere Masque, Sam Dupont, Magali Zapata, Michel Warnau, Carlos M. Alonso-Hernandez

Research outputs 2022 to 2026

No abstract provided.

Assessment Of Physiological & Biochemical Changes In Tomato Plants Treated With Plant Growth Promoting Rhizobacteria (Pgpr) Under Salinity Stress Conditions, Mohammed Sharif Alhosani

Theses

Plant growth-promoting rhizobacteria (PGPRs) can effectively mitigate the negative impacts of salt stress on plants. The present study reports the isolation of PGPRs from a high-saline mangrove ecosystem in Abu Dhabi, with isolates exhibiting ACC deaminase (ACCD) activity to reduce stress-induced ethylene, along with additional plant growth-promoting (PGP) characteristics, including phosphate solubilization (P+). A total of 57 salt-tolerant bacterial isolates from the mangrove rhizosphere were initially screened for ACCD and P+ activities. Of these, 24 isolates tested positive for PGP characteristics and were further evaluated for their ability to enhance salt stress tolerance in tomato seedlings. In addition, seedlings inoculated …

Food Self-Sufficiency And Building-Integrated Urban Agriculture: Lessons From Singapore, Tomoki Fujii, Christoph Waibel, Xinyi Du, Zhongming Shi

Research Collection School Of Economics

Singapore aims to achieve 30 percent food self-sufficiency by 2030, known as the 30-by-30 target, and this paper reviews Singapore’s changing landscape for urban agriculture and its recent progress towards the 30-by-30 goal, highlighting key challenges such as land constraints, high production costs, and resource limitations. Building-integrated agriculture (BIA), which utilizes building surfaces such as rooftops, façades, and balconies for food production within urban environments, is examined as a potential way to increase self-sufficiency through a simulation. Despite the BIA’s potential, practical issues—including regulatory concerns and infrastructure limitations—must be addressed before it can be implemented at scale. Insights from Singapore’s …

The Relationship Between Food Insecurity And Emotional Eating During The Coronavirus Pandemic In Northern California, Andreza S.B. Souza, Marcelle M. Dougan, Giselle A.P. Pignotti

Faculty Research, Scholarly, and Creative Activity

Objectives: This cross-sectional study examined the association between food insecurity and emotional eating and explored correlations between emotional eating and dietary behavior in the U.S during the pandemic. Methods: Participants (N = 515, 77.1 % female, 44.1 ± 14.7 years old) completed a validated online survey between August and November of 2020 including questions about food security and eating behaviors. A multivariable linear regression model was used to evaluate the association between food insecurity and emotional eating. Pearson correlations were calculated to assess the relationship between emotional eating and dietary behavior Results: Overall, 31.3 % of the participants experienced food …

Revised Final Multi-Pathway Residential Metals Abatement Program Plan, Atlantic Richfield Company, Butte Silver Bow

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Global Review Of Consumer Preferences And Willingness To Pay For Edible Insects And Derived Products, Zewdu Abro, Kibrom T. Sibhatu, Gebeyehu Manie Fetene, Mohammed Hussen Alemu, Chrysantus M. Tanga, Subramanian Sevga, Menale Kassie

All Peer-Reviewed Publications

The rising global demand for protein, driven by population growth, urbanization, economic development, and climate change, underscores the need for sustainable alternative protein sources. Edible insects have emerged as a viable solution to enhance foodfeed and nutritional security while contributing to waste management. This study reviews 128 peer-reviewed publications to assess consumer preferences and willingness to pay (WTP) for edible insects and their derivatives. Findings reveal that studies predominantly focus on Europe and insect-based foods, with limited research on insect-based feeds and derived products. Consumers in Africa, Asia, and Latin America show higher acceptance of insect-based food compared to those …

Anti-Suit Injunctions And Dispute Resolution Clauses, Adeline Chong

Research Collection Yong Pung How School Of Law

In two decisions decided within a fortnight of each other, the Singapore Court of Appeal considered anti-suit injunctions pursued to restrain proceedings allegedly brought in breach of arbitration agreements. The first case, Asiana Airlines, Inc v Gate Gourmet Korea Co, Ltd (‘Asiana Airlines’)[1] dealt with whether A could rely on an arbitration agreement between A and B to restrain B’s proceedings against C, a third party. The second case, COSCO Shipping Specialized Carriers Co, Ltd v PT OKI Pulp & Paper Mills (‘COSCO Shipping’)[2] considered whether an arbitration agreement covered a tortious claim. To put it in another way, Asiana …

Revised Final - Multi-Pathway Residential Metals Abatement Program Plan, Butte-Silver Bow Department Of Reclamation And Environmental Services, Atlantic Richfield Company

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Understanding Dairy Livestock Farmers' Intention To Adopt Sociocultural Dynamics For Food Security Using The Theory Of Planned Behaviour, Paresh Kumar Sarma, Mohammad Jahanghir Alam, Samiha Sarwar, Sadika Haque, Golam Rabbani, Ismat Ara Begum, Andrew M. Mckenzie

Agricultural Economics and Agribusiness Faculty Publications and Presentations

This study examines the impact of socio-cultural dynamics (SCD) on food and nutrition security in dairy farming households. Recognizing the role of cultural practices, social networks, and access to resources in shaping food security, we emphasize the need to incorporate these factors into interventions for dairy farming. Using a systematic random sampling technique, we surveyed 400 households in the Rajbari District of Bangladesh in 2024 and analyzed the data using the Theory of Planned Behavior (TPB) and the Partial Least Square-Structural Equation Model (PLS-SEM model). The results revealed a positive association between the intention to adopt socio-cultural dynamics and food …

Poder Familiar: A Culturally Tailored Health Intervention For Latino Families Of Children With Intellectual And Developmental Disabilities, Amy Pei-Lung Yu, Yolanda Suarez-Balcazar, Vanessa L. Errisuriz, Deborah Parra-Medina, Mansha Mirza, Minyu Zhang, Pei-Chiang Lee, Weiwen Zeng, Jasmine P. Brown-Hollie, Nazanin M. Heydarian

School of Social Work Faculty Publications

Background: This two-site pilot study examined the feasibility, acceptability and preliminary outcomes of PODER Familiar, a culturally tailored intervention to promote the health and well-being of Latina family caregivers and their children with intellectual and developmental disabilities.

Method: Using the Promotora de Salud model and mixed-methods design, we co-developed PODER Familiar with Latina caregivers of children with intellectual and developmental disabilities and community stakeholders. Thirty Latina caregivers and their children with disabilities were recruited to participate in the intervention, which included 10 individual sessions and 3 group sessions.

Results: Twenty-six Latina caregivers completed all 10 individual sessions, with high intervention …

Revisiting Diagnostics: High Priority Tuberculosis Diagnostic Tests That Fill An Unmet Need: What We Need And What We Do Not Need, Christoph Lange, Anna Maria Mandalakas, Troels Lillebaek, Dumitru Chesov, Keertan Dheda, Francesca Saluzzo

Faculty, Staff and Students Publications

No abstract provided.

Altered Thermal Preference By Preoptic Estrogen Receptor Alpha Neurons In Postpartum Females, Nan Zhang, Meng Yu, Qianru Zhao, Bing Feng, Yue Deng, Jonathan C Bean, Qingzhuo Liu, Benjamin P Eappen, Yang He, Kristine M Conde, Hailan Liu, Yongjie Yang, Longlong Tu, Mengjie Wang, Yongxiang Li, Na Yin, Hesong Liu, Junying Han, Darah Ave Threat, Nathan Xu, Taylor Smiley, Pingwen Xu, Lulu Chen, Tianshu Zeng, Yanlin He, Chunmei Wang

Faculty, Staff and Students Publications

OBJECTIVE: This study aims to investigate how reproductive experience (RE) alters thermal preference and thermoregulation in female mice, with a focus on estrogen receptor alpha (ERα)-expressing neurons in the preoptic area (POA).

METHODS: Thermal preference and body temperature were measured in female mice with and without RE, and virgin female mice with selective deletion of ERα from the POA (ERα

RESULTS: We showed that female mice prefer a cooler environment starting from late pregnancy and persisting long term postpartum. Female mice with RE (>4 weeks post-weaning) displayed lower body temperature and a lower thermal preferred temperature, and lost preference …

Epidemiology Of Diagnostic Errors In Pediatric Emergency Departments Using Electronic Triggers, Prashant Mahajan, Emily White, Kathy Shaw, Sarah J Parker, James Chamberlain, Richard M Ruddy, Elizabeth R Alpern, Jacqueline Corboy, Andrew Krack, Brandon Ku, Daphne Morrison Ponce, Asha S Payne, Elizabeth Freiheit, Gregor Horvath, Giselle Kolenic, Michele Carney, Nicole Klekowski, Karen J O'Connell, Hardeep Singh

Faculty, Staff and Students Publications

Objectives: We applied three electronic triggers to study frequency and contributory factors of missed opportunities for improving diagnosis (MOIDs) in pediatric emergency departments (EDs): return visits within 10 days resulting in admission (Trigger 1), care escalation within 24 h of ED presentation (Trigger 2), and death within 24 h of ED visit (Trigger 3).

Methods: We created an electronic query and reporting template for the triggers and applied them to electronic health record systems of five pediatric EDs for visits from 2019. Clinician reviewers manually screened identified charts and initially categorized them as "unlikely for MOIDs" or "unable to rule …

Insulin Clearance At Randomisation And In Response To Treatment In Youth With Type 2 Diabetes: A Secondary Analysis Of The Today Randomised Clinical Trial, Kristen J Nadeau, Silva A Arslanian, Fida Bacha, Sonia Caprio, Lily C Chao, Ryan Farrell, Kara S Hughan, Maria Rayas, Melinda Tung, Kaitlyn Cross, Laure El Ghormli

Children’s Nutrition Research Center Staff Publications

Aims/hypothesis: Insulin resistance and compensatory hyperinsulinaemia are core features leading to beta cell failure in youth-onset type 2 diabetes. Insulin clearance (IC) is also a key regulator of insulin concentrations, but few data exist on IC in youth-onset type 2 diabetes. In a secondary analysis of our Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) randomised clinical trial, we investigated potential sex-, race-, ethnicity- and treatment-related differences in IC in youth-onset type 2 diabetes and aimed to identify metabolic phenotypes associated with IC at baseline and in response to metformin, metformin plus a lifestyle intervention, and metformin …

Quantitative Profiling Ph Heterogeneity Of Acidic Endolysosomal Compartments Using Fluorescence Lifetime Imaging Microscopy, Dinghuan Deng, Youchen Guan, Ayse Sena Mutlu, Baiping Wang, Shihong Max Gao, Hui Zheng, Meng C Wang

Center on Aging Staff Publications

The endolysosomal system plays a crucial role in maintaining cellular homeostasis and promoting organism fitness. The pH of its acidic compartments is a crucial parameter for proper function, and it is dynamically influenced by both intracellular and environmental factors. Here, we present a method based on fluorescence lifetime imaging microscopy (FLIM) for quantitatively analyzing the pH profiles of acidic endolysosomal compartments in diverse types of primary mammalian cells and in live organism Caenorhabditis elegans. This FLIM-based method exhibits high sensitivity in resolving subtle pH differences, thereby revealing heterogeneity within a cell and across cell types. This method enables rapid …

The Relationship Between Irritable Bowel Syndrome And Metabolic Syndrome: A Systematic Review And Meta‐Analysis Of 49,662 Individuals, Yomna E. Dean, Jose J. Loayza Pintado, Samah S. Rouzan, Lucy L. Nale, Ahmed Abbas, Abdulla Aboushaira, Farah Alkasajy, Ahmed A. Ghanem, Vinayak Mahesh Patil, Yana Gordeyeva

School of Medicine Publications

Background

Studies have shown mixed results regarding the association between irritable bowel syndrome (IBS) and metabolic syndrome (MS); This study aimed to assess the susceptibility of IBS patients to MS and its individual components.

Methods

PubMed, Scopus, Embase, and Web of Science were searched on 1/1/2023. Eligible studies were screened, and data on study characteristics, IBS diagnostic criteria, and metabolic syndrome components were extracted. Data were analysed in RevMan 5.4, with results reported as relative risk (RR) or mean difference (MD) and 95% confidence intervals. Statistical significance was set at p <  0.05.

Results

IBS was associated with an increased risk of …

Treatment Of Osteoporosis And Osteoarthritis In The Oldest Old, Daniel Pinto

Physical Therapy Faculty Research and Publications

Osteoporosis and osteoarthritis are key diseases of musculoskeletal ageing and are increasing in prevalence and burden with the progressively ageing population worldwide. These conditions are thus particularly common in ‘the oldest old’, and there are complexities of managing them within the context of extensive multimorbidity, physical and mental disability, and polypharmacy, the rates for all of which are high in this population. In this narrative review, we explore the epidemiology of osteoporosis and osteoarthritis in the oldest old before examining trials and real-world data relating to the pharmacological treatment of these diseases in older adults, including anti-resorptives and bone-forming agents …

Early Life Epigenetics And Childhood Outcomes: A Scoping Review, Srirupa Hari Gopal, Theresa Alenghat, Mohan Pammi

Faculty, Staff and Students Publications

Epigenetics is the study of changes in gene expression, without a change in the DNA sequence that are potentially heritable. Epigenetic mechanisms such as DNA methylation, histone modifications, and small non-coding RNA (sncRNA) changes have been studied in various childhood disorders. Causal links to maternal health and toxin exposures can introduce epigenetic modifications to the fetal DNA, which can be detected in the cord blood. Cord blood epigenetic modifications provide evidence of in-utero stressors and immediate postnatal changes, which can impact both short and long-term outcomes in children. The mechanisms of these epigenetic changes can be leveraged for prevention, early …

Modeling The Kinetics Of Interorgan Arginine Metabolism During Bacterial Sepsis In Swine, Caitlin Vonderohe, Douglas Burrin

Faculty, Staff and Students Publications

No abstract provided.

Rising Mortality Rates Linked To Type-2 Diabetes And Obesity In The United States: An Observational Analysis From 1999 To 2022, Mushood Ahmed, Abdullah Nofal, Aimen Shafiq, Hira Javaid, Areeba Ahsan, Zain Ali Nadeem, Raheel Ahmed, Mahboob Alam, Mamas A Mamas, Marat Fudim, Gregg C Fonarow

Faculty, Staff and Students Publications

Background: The prevalence of type 2 diabetes (T2D) and obesity are increasing in the United States. However, population-level data for mortality trends due to T2D and obesity are limited. This study aims to assess these death trends among adults in the United States categorized by sex, race, and geographical location.

Methods: We queried the CDC-WONDER database for multiple cause of death data of adults aged ≥25 years. The crude mortality rates (CMR), age-adjusted mortality rates (AAMRs), annual percent change (APC), and the average APC (AAPC) along with a 95% confidence interval (CI) were analyzed.

Results: From 1999 to 2022, a …

Can Targeting The Fgf23-Αklotho Signaling System Delay Phosphate-Driven Organ Damage?, Mohammed S. Razzaque, Moosa Mohammadi

School of Medicine Publications

Introduction: Inexorable high serum phosphate levels in chronic kidney disease (CKD) patients deteriorate the functionality of the musculoskeletal, renal, and cardiovascular systems, thereby contributing to increased morbidity and mortality. Higher phosphate balance has also been correlated with increased mortality rates in individuals with normal renal function, independent of other comorbidities. Clinical and epidemiological studies of CKD patients and healthy subjects, alongside evidence of accelerated aging in murine models induced by excessive phosphate loading, indicate that phosphate toxicity is a driver of premature aging and age-related organ damage.

Area covered: This article briefly discusses the causes and consequences of phosphate toxicity …

Exploration Of Cytokines And Microbiome Among Males And Females With Diarrhea-Predominant Irritable Bowel Syndrome, Li Juen Chen, Anna M Plantinga, Robert Burr, Kevin Cain, Pamela Barney, Tor Savidge, Robert J Shulman, Margaret Heitkemper, Kendra Kamp

Faculty, Staff and Students Publications

Background: Whether pathophysiological factors differ between males and females with irritable bowel syndrome-diarrhea (IBS-D) remains to be tested. To better understand potential sex differences, males with IBS-D were compared to naturally cycling females and to females with IBS-D taking hormonal contraception on plasma levels of cytokines and gut microbiome characteristics.

Methods: Males and females with Rome III IBS-D completed questionnaires and kept a daily symptom diary for 28 days. Blood and stool samples were collected between days 3 and 8 of the daily diary (estrogen-dominant days in naturally cycling females). Blood samples were analyzed for lipopolysaccharide (LPS)-stimulated and unstimulated cytokine …