Digital Commons Network^™

Stereospecific Cross-Coupling Reactions Of Enantioenriched Secondary Alkyltricyclohexyltin Nucleophiles, Meruyert Binayeva

Dissertations, Theses, and Capstone Projects

Transition metal-catalyzed cross-coupling reactions have evolved into a remarkable instrument for the formation of new bonds, and have significantly impacted how we approach to access complex organic molecules. Palladium is currently one of the most popular elements for catalytic applications due to its ability to facilitate powerful carbon-carbon and carbon-heteroatom couplings. Traditional Pd-catalyzed cross-coupling reactions have primarily concentrated on C(sp2)-C(sp2) cross-couplings, yielding planar products. Considering the use of C(sp3) nucleophiles would offer a viable control of the three dimensional arrangement in molecules. Herein, the first chapter details the history and development of Pd-catalyzed Stille cross-coupling reactions. The use of configurationally …

Cinema And Ritual: Decolonial Feminist Approaches To Image-Making In The Americas And The Caribbean, Natalie M. Erazo

Dissertations, Theses, and Capstone Projects

This thesis project is composed of an open-access syllabus hosted on a CUNY commons site, as well as a paper that examines various films and texts responding to the theme of cinema and ritual. Referenced films will focus on ritual as a decolonial feminist methodological framework, rooted primarily in Afro-descended and Indigenous cosmovisions within Latin America and the Caribbean. From a dance ritual spell warding off U.S. imperialism in present-day Puerto Rico, to a poetic visual eulogy for murdered women in rural Mexico, to a community prayer to Yemaya bringing relief for water scarcity in Cuba to a cautionary tale …

Power And The Press: Reimagining The World By Producing Information Together, Jen Hoyer

Dissertations, Theses, and Capstone Projects

This study of three collectively-organized activist printing projects examines how information production is a strategy for communities to reimagine and reconfigure oppressive power structures. I consider the High School Student Union and their newspaper, the High School Free Press; the women’s collective that took over RAT Subterranean News; and WIMP, a radical printing collective that broke away from the New York City Students for a Democratic Society chapter and supported a variety of progressive movements in New York City in the late 1960s and early 1970s. This research examines how dissatisfaction with oppressive power structures leads individuals to build collective …

Mechanistic And Engineering Studies Of Lov Photoreceptors In Yeast, Matthew M. Cleere

Dissertations, Theses, and Capstone Projects

A variety of cellular biosensors have evolved which can translate electromagnetic radiation from the environment into biological functions. Light-Oxygen-Voltage (LOV) domains in particular, are a group of photoreceptors that respond to blue wavelengths of light and can become a cellular photoswitch by converting this stimulus through their attached effector domains. For instance, the Helix-Turn-Helix (HTH) DNA-binding activity of the bacterial transcription factor EL222 and the Regulator of G-protein Signaling (RGS) in the fungal membrane associating protein BcLOV4 are both induced by blue-light sensing LOV domains. While previous work has provided the field with a structural characterization of LOV proteins in …

A Candidate Needs Approach To Job Advertisements, Yuliya M. Cheban-Gore

Dissertations, Theses, and Capstone Projects

Organizations currently lack research-based best practice guidance on what information is most helpful for job seekers when deciding which jobs and organizations to apply to. This lack of guidance is a detriment because, typically, recruitment strategies are designed from the perspective of the organization’s needs –which is effective when the job market is organization, rather than candidate-driven. When the market is candidate-driven, it would benefit organizations to view the recruitment process through the lens of job seekers. The current studies focus on understanding one of the beginning stages of recruitment through the lens of job seekers: job advertisements. Through a …

Values In Evidence-Based Policy: Bridging Socio-Political, Moral, And Epistemic Domains, Karyna Pryiomka

Dissertations, Theses, and Capstone Projects

Values constitute an inescapable constant of any policymaking or evidence-production process. In this dissertation I explore ways in which socio-political, moral, and epistemic values inform evidence production and use in public higher education policy. In “Chapter One: Introduction and Literature Review”, I provide a brief overview of evidence-based policy as a practice. I then discuss three major categories of values, focusing on higher education examples whenever possible. Finally, I present the central study of this dissertation. The central question of my dissertation is In what ways do epistemic, socio-political, and moral values frame the production and deployment of evidence in …

From The Outside Looking In: Transmasculine Narrative Identity, Experiences, And Larger Narratives On Social Media, Micah Roldan

Dissertations, Theses, and Capstone Projects

Narrative identity development is an essential process in how individuals perceive themselves and the world around them. Often, narrative identity is studied in cisgender heterosexual individuals and applied to others without the acknowledgment of individuals that fall outside of these categories. Drawing upon existing literature and autoethnography, this thesis aims to meaningfully bridge this gap by studying the narrative identity development of transmasculine individuals through the lens of social media. This thesis proposes that the use of social media to share gender transition journeys has created a new digital trans and queer narrative for users and viewers. This narrative is …

Regulation Of The Intracellular Trafficking Of Ajuba By Cell Density And Cell Cycle-Dependent Mechanisms, Huanhuan Sun

Dissertations, Theses, and Capstone Projects

The intracellular localization of Ajuba, a LIM domain-containing protein, holds essential value for various cellular activities. Previous studies from the laboratory have implicated Ajuba as a repressor of ATR in human cells. This study focused on unveiling the intricate mechanisms governing Ajuba's localization dynamics through studies of its intracellular trafficking under cell cycle-dependent changes, and responses to cell density. Through targeted deletion experiments, it was found that Ajuba's LIM domain plays an essential role in its nuclear localization, while a nuclear export signal (NES) in its preLIM domain guides its exit from the nucleus to the cytoplasm. The essential role …

The Black Map Project: A Black People’S Epistemology Of Healing, Britton Williams

Dissertations, Theses, and Capstone Projects

This work is a love letter to Mary Turner and her descendants, by which I mean all Black people, that lifts recipes and roadmaps of Black creative healing and liberatory praxes. It is a freedom dream (Kelley, 2002) that dares to (re)imagine mental health care by holding Black healing and liberation centrally in mind. I do not seek to prove through this work but rather to provoke [thought|action|repair]. In this work, I unsettle prescribed notions of therapy that have long dismissed/erased/ignored the needs and [therapeutic] practices of Black people. The Black MAP Project resists epistemologies of ignorance (Mills, 2022)—born in …

Visualizing Ancient Empire In Tudor England: Imperial Monarchy, Reformation, And The Antique Soldier In The Title Page To Richard Grafton’S Large Chronicle (1569), Peter Nicholas Otis

Dissertations, Theses, and Capstone Projects

This thesis analyzes the iconography and visual sources of the title page to the first volume of A chronicle at large and meere history of the affayres of Englande (1569) by the Tudor author Richard Grafton. Representing the visual synthesis of several distinct but interrelated currents that developed in the preceding century, the title page to the Large Chronicle offers a rare glimpse into a transitional moment in the middle Tudor perception and visual representation of the British past. These currents include imperializing royal iconography, with origins in antecedent representations in the late fifteenth century; the entry of the ‘classicizing’ …

Cancer In Pajamas: Radio, Podcasts, And The Politics Of Free Time In The Digital Age, Daniel Grjonko

Dissertations, Theses, and Capstone Projects

The podcast, an extremely potent fermentation of the radio which was so central to many of the Frankfurt School thinkers, is an important political subject to consider in light of rekindled social discussions concerning a society straddling the line between fascism and socialism. Especially the political podcast, which has become a pulse of intellectual discussion and historical analysis, promises itself simultaneously as a medium of entertainment, pedagogy, and translation into real-world organizing for a different world, true for both the left and the right. The truth, I propose, is a sinister other experience, one which maintains the status quo …

Knowing The Patient As A Person: Social Media Listening And Gadamerian Analysis Of Nurses’ Expressions Shared During The Covid-19 Global Health Pandemic, Janusz A. Kaleta

Dissertations, Theses, and Capstone Projects

Background: COVID-19 has dramatically changed human-to-human interactions from in-person to the nonhuman domain of virtual space. In January 2021, every 28 seconds one person died of COVID-19 in the United States. An average of 3,100 Americans died each day during the deadliest month of the pandemic. As of January 2023, the number of COVID-19 deaths in the USA surpassed 1.000.000 people. In hospitals, human-to-human interactions were often limited to seeing one’s eyes behind the face shields, and respirator masks, and hearing a muffled voice, or sounds of the ventilators. In New York State 452 nurses died during the pandemic.

Research …

Interviews And Perspectives Among Community Members Working With Undocumented Female Border Crossers In The States Along The United States-Mexico Border, Melissa M. Frasco

Dissertations, Theses, and Capstone Projects

In order to discuss immigration in the context of the United States, we must dispel the myth that immigration is monolithic. Therefore, when we discuss national identity, gender equality, policy, employment rates, and countless other ordinary topics, we are discussing immigration, as it is embedded in our history and our future. The goal of my research is to delineate the experiences of violence that female border crossers undergo in the process of crossing into the United States via the southernmost border. The data collection process involved four semi-structured interviews to collect oral histories from workers at community-based organizations. These organizations …

Containerization Of Seafarers In The International Shipping Industry: Contemporary Seamanship, Maritime Social Infrastructures, And Mobility Politics Of Global Logistics, Liang Wu

Dissertations, Theses, and Capstone Projects

This dissertation discusses the mobility politics of container shipping and argues that technological development, political-economic order, and social infrastructure co-produce one another. Containerization, the use of standardized containers to carry cargo across modes of transportation that is said to have revolutionized and globalized international trade since the late 1950s, has served to expand and extend the power of international coalitions of states and corporations to control the movements of commodities (shipments) and labor (seafarers). The advent and development of containerization was driven by a sociotechnical imaginary and international social contract of seamless shipping and cargo flows. In practice, this liberal, …

Seeing Safety In Red: Expressions Of Interpersonal Gratitude Affects Conservatives’ Political Attitudes In The United States, Kyle M. Anderson

Dissertations, Theses, and Capstone Projects

The current research focuses on how the expression of interpersonal gratitude might affect conservative attitudes, behaviors, and policy support in the United States. This was investigated either through expressions of gratitude or receiving gratitude to an interpersonally close other, as in Studies 1 and 2, or expressing gratitude to an authority figure or equal in one’s life, as in Study 3. Study 1 showed that expressing gratitude, relative to receiving gratitude, reduced support for general conservative ideology. Using serial mediation analyses, Study 2 demonstrated that expressions of gratitude, relative to receiving gratitude, directly reduced perceptions of relational uncertainty, which increased …

Deep Learning-Based Human Action Understanding In Videos, Elahe Vahdani

Dissertations, Theses, and Capstone Projects

The understanding of human actions in videos holds immense potential for technological advancement and societal betterment. This thesis explores fundamental aspects of this field, including action recognition in trimmed clips and action localization in untrimmed videos. Trimmed videos contain only one action instance, with moments before or after the action excluded from the video. However, the majority of videos captured in unconstrained environments, often referred to as untrimmed videos, are naturally unsegmented. Untrimmed videos are typically lengthy and may encompass multiple action instances, along with the moments preceding or following each action, as well as transitions between actions. In the …

Rational Design Of Peptide-Based Materials Informed By Multiscale Molecular Dynamics Simulations, Dhwanit Rahul Dave

Dissertations, Theses, and Capstone Projects

The challenge of establishing a sustainable and circular economy for materials in medicine and technology necessitates bioinspired design. Nature's intricate machinery, forged through evolution, relies on a finite set of biomolecular building blocks with through-bond and through-space interactions. Repurposing these molecular building blocks requires a seamless integration of computational modeling, design, and experimental validation. The tools and concepts developed in this thesis pioneer new directions in peptide-materials design, grounded in fundamental principles of physical chemistry. We present a synergistic approach that integrates experimental designs and computational methods, specifically molecular dynamics simulations, to gain in-depth molecular insights crucial for advancing the …

Digital Rhetoric Of The Invisible: Bisexual Literacy Practices On Tiktok, 2020–2021, Olivia Wood

Dissertations, Theses, and Capstone Projects

This dissertation uses auto- and digital-ethnographic methods to analyze the literacy practices of bisexual TikTok users primarily during the first year of the Covid-19 pandemic in the United States, during which time TikTok exploded in popularity among U.S. social media users, especially among young adults. It is also an exercise in neuroqueer composing, diverging at times from the norms of academic writing and the dissertation genre to perform and intentionally draw attention to neuroqueer styles of thinking and communication. I argue that bisexual invisibility and contemporary bi+ rhetorical activity must be understood within the context of LGBTQ+ political history, particularly …

Algorithmic Love: Twenty-First Century Organizations Of The Romantic, Sandra Moyano Ariza

Dissertations, Theses, and Capstone Projects

This dissertation investigates the highly computed and accelerated experiences of digital love as well as their cultural and artistic representations in order to shed light on the human and more-than-human entanglements producing the algorithmic love experience. The recent turn to love in critical theory and cultural studies examines how love circulates in neoliberal societies and in the subjective processes of the users, foregrounding the control of populations and the very much lamented “end of love” (Illouz 2019). My study of love supplements the neoliberalist critique of algorithmic love with a posthuman and media theory approach that attends to the material …

No Ela Without Ella: Understanding The Naming And Crafting Of Gendered Subjectivities In Puerto Rico, Carmín Quijano Seda

Dissertations, Theses, and Capstone Projects

At the beginning of the 20th century, the official metadiscourses about gendered job titles sedimented the idea that names or indexes pointing to women should be interpreted as unskilled, cheap, or even free labor in Puerto Rico (Azize, 1985; Muñiz Mas, 1998; Baerga-Santini, 1999). For this reason, Puerto Rican women organized and fought for equality in work settings. Furthermore, they became more active in politics and the government. Nevertheless, the Estado Libre Asociado (ELA) and local media discourses and interpretations about women’s labor discouraged them from participating in more senior positions (Acevedo Gaud, 2012).

However, this interpretation seemed to have …

Critical-Race Elementary Schooling: Critical-Race Teacher Change Agents Are Challenging Whiteness In Elementary Schools, David R. Rosas

Dissertations, Theses, and Capstone Projects

Children in elementary schools think, talk, and reason in big ways that reflect how they live and experience race, racism, and racialization. Some elementary school teachers -- or critical-race teacher change agents -- intentionally include this work in their classrooms. My aim is to find out what motivates critical-race teacher change agents to challenge Whiteness in their classrooms and understand what they say they do to challenge Whiteness with young children.

An emphasis on racial-justice work in elementary schools has often been overlooked by teacher education and has been further pushed back by the recent backlash on critical race theory …

Frenetic Journey Toward Muddledness: An Experimental Short Film, Fernando Vieira

Dissertations, Theses, and Capstone Projects

As an artist and Film Studies student, I saw the capstone option as an opportunity to consolidate academia with the art of filmmaking into one project. This became Frenetic Journey Toward Muddledness, an experimental short film written, directed, and edited by me. It is a film influenced by early avant-garde cinema, German expressionism, and film noir. Composed of pieces of unrelated footage and featuring an ambiguous, non-linear, and mostly silent narrative, the editing of the film prompted me to ask myself questions about its genre. Its hybridity made it possible to position the film within different categories, but there …

“After Being Equals, Is This The Sequel?”: Vivian Fine’S Memoirs Of Uliana Rooney As Artistic Commentary On Shifting Reactions To American Women’S Music, Tonia L. Passwater

Dissertations, Theses, and Capstone Projects

Although it has been acknowledged that American female modernist composers encountered obstacles to success, the nuanced and multi-faceted nature of these obstacles has yet to be fully examined. In this dissertation, I explore the worlds of Marion Bauer, Johanna Beyer, Vivian Fine, Miriam Gideon, and Ruth Crawford Seeger through the lenses of music history, reception history, and socio-linguistics in order to contribute a more thorough understanding of the obstacles women encountered.

Before a note composed by a woman was ever heard, a battle was being waged with gendered identities. These identities are the starting point for my analysis of obstacles …

Culturally And Socially Responsive Teacher Professional Learning At The American Museum Of Natural History, Jessica Correa

Dissertations, Theses, and Capstone Projects

This capstone project consists of a series of professional learning sessions to support teachers in their implementation of Culturally Responsive-Sustaining Education (CR-SE) using the American Museum of Natural History (AMNH) as a resource and case study. Through the lens of Historically Responsive Literacy, the series also seeks to reestablish social science as a critical element of natural history for teachers. This series can help teachers see the museum as not only a place to explore life and physical science, but also a place to explore identity, social/emotional development, cultural studies and American History. The project includes resources and directions for …

Zika Virus Co-Opts Microrna Networks To Persist In Placental Niches Detected By Spatial Transcriptomics, Enrico R Barrozo, Maxim D Seferovic, Mark P Hamilton, David N Moorshead, Michael D Jochum, Trang Do, Derek S O'Neil, Melissa A Suter, Kjersti M Aagaard

Faculty, Staff and Students Publications

BACKGROUND: Zika virus congenital infection evades double-stranded RNA detection and may persist in the placenta for the duration of pregnancy without accompanying overt histopathologic inflammation. Understanding how viruses can persist and replicate in the placenta without causing overt cellular or tissue damage is fundamental to deciphering mechanisms of maternal-fetal vertical transmission.

OBJECTIVE: Placenta-specific microRNAs are believed to be a tenet of viral resistance at the maternal-fetal interface. We aimed to test the hypothesis that the Zika virus functionally disrupts placental microRNAs, enabling viral persistence and fetal pathogenesis.

STUDY DESIGN: To test this hypothesis, we used orthogonal approaches in human and …

Biallelic Creld1 Variants Cause A Multisystem Syndrome, Including Neurodevelopmental Phenotypes, Cardiac Dysrhythmias, And Frequent Infections, Lauren Jeffries, Emily K Mis, Kirsty Mcwalter, Sandra Donkervoort, Nina N Brodsky, Jean-Marie Carpier, Weizhen Ji, Cristian Ionita, Bhaskar Roy, Jon S Morrow, Armine Darbinyan, Krishna Iyer, Ritu B Aul, Siddharth Banka, Katherine R Chao, Laura Cobbold, Stacey Cohen, Helena M Custodio, Margaret Drummond-Borg, Frances Elmslie, Erika Finanger, Bryan E Hainline, Ingo Helbig, Stacy Hewson, Ying Hu, Adam Jackson, Dragana Josifova, Monica Konstantino, Meganne E Leach, Bryan Mak, David Mccormick, Elisabeth Mcgee, Stanley Nelson, Joanne Nguyen, Kimberly Nugent, Lucy Ortega, Howard P Goodkin, Elizabeth Roeder, Sani Roy, Katie Sapp, Dimah Saade, Sanjay M Sisodiya, Karen Stals, Shelley Towner, William Wilson, Deciphering Developmental Disorders, Genomics England Research Consortium, Undiagnosed Disease Network, Mustafa K Khokha, Carsten G Bönnemann, Carrie L Lucas, Saquib A Lakhani

Faculty, Staff and Students Publications

PURPOSE: We sought to delineate a multisystem disorder caused by recessive cysteine-rich with epidermal growth factor-like domains 1 (CRELD1) gene variants.

METHODS: The impact of CRELD1 variants was characterized through an international collaboration utilizing next-generation DNA sequencing, gene knockdown, and protein overexpression in Xenopus tropicalis, and in vitro analysis of patient immune cells.

RESULTS: Biallelic variants in CRELD1 were found in 18 participants from 14 families. Affected individuals displayed an array of phenotypes involving developmental delay, early-onset epilepsy, and hypotonia, with about half demonstrating cardiac arrhythmias and some experiencing recurrent infections. Most harbored a frameshift in trans with a missense …

Genome-Wide P63-Target Gene Analyses Reveal Tap63/Nrf2-Dependent Oxidative Stress Responses, Marco Napoli, Avani A Deshpande, Deepavali Chakravarti, Kimal Rajapakshe, Preethi H Gunaratne, Cristian Coarfa, Elsa R Flores

Faculty, Staff and Students Publications

The p53 family member TP63 encodes two sets of N-terminal isoforms, TAp63 and ΔNp63 isoforms. They each regulate diverse biological functions in epidermal morphogenesis and in cancer. In the skin, where their activities have been extensively characterized, TAp63 prevents premature aging by regulating the quiescence and genomic stability of stem cells required for wound healing and hair regeneration, while ΔNp63 controls maintenance and terminal differentiation of epidermal basal cells. This functional diversity is surprising given that these isoforms share a high degree of similarity, including an identical sequence for a DNA-binding domain. To understand the mechanisms of the transcriptional programs …

Study Design And Methods: Us Study To Protect Brain Health Through Lifestyle Intervention To Reduce Risk (Us Pointer), Laura D Baker, Heather M Snyder, Mark A Espeland, Rachel A Whitmer, Miia Kivipelto, Nancy Woolard, Jeffrey Katula, Kathryn V Papp, Jennifer Ventrelle, Sarah Graef, Marcus A Hill, Scott Rushing, Julia Spell, Laura Lovato, Deborah Felton, Benjamin J Williams, Mina Ghadimi Nouran, Rema Raman, Tiia Ngandu, Alina Solomon, Sharon Wilmoth, Maryjo L Cleveland, Jeff D Williamson, Katherine L Lambert, Sarah Tomaszewski Farias, Claire E Day, Christy C Tangney, Darren R Gitelman, Olivia Matongo, Terrianne Reynolds, Valory N Pavlik, Melissa M Yu, Ashley S Alexander, Richard Elbein, Ann Marie Mcdonald, Stephen Salloway, Rena R Wing, Susan Antkowiak, Martha Clare Morris, Maria C Carrillo

Faculty, Staff and Students Publications

INTRODUCTION: The U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER) is conducted to confirm and expand the results of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) in Americans.

METHODS: U.S. POINTER was planned as a 2-year randomized controlled trial of two lifestyle interventions in 2000 older adults at risk for dementia due to well-established factors. The primary outcome is a global cognition composite that permits harmonization with FINGER.

RESULTS: U.S. POINTER is centrally coordinated and conducted at five clinical sites (ClinicalTrials.gov: NCT03688126). Outcomes assessments are completed at baseline and …

A Conversation On The Carceral Home, Ngozi Okidegbe, Kate Weisburd, Emmett Sanders, James Kilgore

Faculty Scholarship

On February 8, 2024, scholars Ngozi Okidegbe, Kate Weisburd, Emmett Sanders, and James Kilgore met virtually at the Boston University School of Law to hold a conversation on Professor Weisburd’s article, The Carceral Home, 103 B.U. L. Rev. 1879 (2023).

Pluripotency Of A Founding Field: Rebranding Developmental Biology, Crystal D Rogers, Chris Amemiya, Swathi Arur, Leslie Babonis, Michael Barresi, Madelaine Bartlett, Richard Behringer, Blair Benham-Pyle, Dominique Bergmann, Ben Blackman, C Titus Brown, Bill Browne, Jasmin Camacho, Chiswili Yves Chabu, Ida Chow, Ondine Cleaver, Jonah Cool, Megan Y Dennis, Alexandra Jazz Dickinson, Stefano Di Talia, Margaret Frank, Stewart Gillmor, Eric S Haag, Iswar Hariharan, Richard Harland, Aman Husbands, Loydie Jerome-Majewska, Kristen Koenig, Carole Labonne, Michael Layden, Chris Lowe, Madhav Mani, Megan Martik, Katelyn Mckown, Cecilia Moens, Christian Mosimann, Joyce Onyenedum, Robert Reed, Ajna Rivera, Dan Rokhsar, Loic Royer, Flora Rutaganira, Rachel Shahan, Neelima Sinha, Billie Swalla, Jaimie M Van Norman, Daniel E Wagner, Athula Wikramanayake, Sophia Zebell, Siobhán M Brady

Faculty, Staff and Student Publications

The field of developmental biology has declined in prominence in recent decades, with off-shoots from the field becoming more fashionable and highly funded. This has created inequity in discovery and opportunity, partly due to the perception that the field is antiquated or not cutting edge. A 'think tank' of scientists from multiple developmental biology-related disciplines came together to define specific challenges in the field that may have inhibited innovation, and to provide tangible solutions to some of the issues facing developmental biology. The community suggestions include a call to the community to help 'rebrand' the field, alongside proposals for additional …