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Genetic Counseling For Adult-Onset Neurogenetic Conditions In Hispanic/Latine Communities: A Qualitative Study Of Barriers And Facilitators From Hispanic/Latine Genetic Counselors' Perspectives, Elizabeth Aleman Jun 2025

Genetic Counseling For Adult-Onset Neurogenetic Conditions In Hispanic/Latine Communities: A Qualitative Study Of Barriers And Facilitators From Hispanic/Latine Genetic Counselors' Perspectives, Elizabeth Aleman

All Publications

Hispanic/Latine (H/Le) individuals, despite being at higher risk for certain adult-onset neurological conditions (AONCs) compared to non-Hispanic white individuals, experience delays in accessing neurologic health services and are significantly underrepresented in clinical research for conditions such as Alzheimer's disease and Parkinson's disease. While existing studies have highlighted barriers to genetic health services for H/Le groups, there is limited research on their experiences with adult-onset conditions beyond cancer. This study aimed to explore the perspectives of H/Le genetic counselors on factors that influence adult neurogenetic counseling (NGC) access for H/Le individuals, and suggestions for expanding access as subject matter experts of …

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A Gut-On-A-Chip Incorporating Human Faecal Samples And Peristalsis Predicts Responses To Immune Checkpoint Inhibitors For Melanoma, Mattia Ballerini, Serena Galiè, Punit Tyagi, Carlotta Catozzi, Hariam Raji, Amir Nabinejad, Angeli D G Macandog, Alessandro Cordiale, Bianca Ionela Slivinschi, Karol K Kugiejko, Martina Freisa, Paola Occhetta, Jennifer A Wargo, Pier F Ferrucci, Emilia Cocorocchio, Nicola Segata, Andrea Vignati, Andrey Morgun, Michela Deleidi, Teresa Manzo, Marco Rasponi, Luigi Nezi Jun 2025

A Gut-On-A-Chip Incorporating Human Faecal Samples And Peristalsis Predicts Responses To Immune Checkpoint Inhibitors For Melanoma, Mattia Ballerini, Serena Galiè, Punit Tyagi, Carlotta Catozzi, Hariam Raji, Amir Nabinejad, Angeli D G Macandog, Alessandro Cordiale, Bianca Ionela Slivinschi, Karol K Kugiejko, Martina Freisa, Paola Occhetta, Jennifer A Wargo, Pier F Ferrucci, Emilia Cocorocchio, Nicola Segata, Andrea Vignati, Andrey Morgun, Michela Deleidi, Teresa Manzo, Marco Rasponi, Luigi Nezi

Faculty, Staff and Student Publications

Patient responses to immune checkpoint inhibitors can be influenced by the gastrointestinal microbiome. Mouse models can be used to study microbiome-host crosstalk, yet their utility is constrained by substantial anatomical, functional, immunological and microbial differences between mice and humans. Here we show that a gut-on-a-chip system mimicking the architecture and functionality of the human intestine by including faecal microbiome and peristaltic-like movements recapitulates microbiome-host interactions and predicts responses to immune checkpoint inhibitors in patients with melanoma. The system is composed of a vascular channel seeded with human microvascular endothelial cells and an intestinal channel with intestinal organoids derived from human …

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Does Third Party Litigation Funding Need Regulations On Consumer Protection, Ronen Avraham, Eric Schuller, Anthony J. Sebok Jun 2025

Does Third Party Litigation Funding Need Regulations On Consumer Protection, Ronen Avraham, Eric Schuller, Anthony J. Sebok

Articles

Transcript of a roundtable discussion during the Third-Party Litigation Symposium at the S.J. Quinney College of Law.

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Contemplative Practices Facilitating Awareness, Compassion, And Healing In Study Abroad: A Reflective And Explorative Study, Ciara C. Hoyne, Jing Lin Jun 2025

Contemplative Practices Facilitating Awareness, Compassion, And Healing In Study Abroad: A Reflective And Explorative Study, Ciara C. Hoyne, Jing Lin

Journal of Contemplative and Holistic Education

This reflective essay focuses on the relationship between contemplative practices and participation in a short-term study abroad trip. The study explores how contemplative practices help facilitate self-understanding, alleviate stress, enhance connection to the host community and culture, and enable healing. We use our experiences participating in a short-term study abroad program as an example for examining the role of contemplative practices in the context of study abroad. We discuss and integrate relevant literature on the topic of meditation, mindfulness, and contemplative inquiry to offer insight into how contemplative practices can be integrated into study abroad in a way that enhances …

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Alterations In Gut Microbiome Composition And Increased Inflammatory Markers In Post-Covid-19 Individuals, Tatiana Barichello, Bruno Kluwe-Schiavon, Laura A Borba, Lucas C Pedro, Flávia S Niero, Laísa N Dos Santos, Letícia M Leonardo, Zuleide M Ignácio, Rodrigo Morales, Luciane B Ceretta, Gislaine Z Reus Jun 2025

Alterations In Gut Microbiome Composition And Increased Inflammatory Markers In Post-Covid-19 Individuals, Tatiana Barichello, Bruno Kluwe-Schiavon, Laura A Borba, Lucas C Pedro, Flávia S Niero, Laísa N Dos Santos, Letícia M Leonardo, Zuleide M Ignácio, Rodrigo Morales, Luciane B Ceretta, Gislaine Z Reus

Faculty, Staff and Student Publications

Dysfunctions in the immune system and alterations in the microbiome composition following SARS-CoV-2 infection contribute to persistent neurological issues observed in long COVID-19 survivors. We hypothesize that alterations in the gut microbiome composition and peripheral inflammatory profile following COVID-19 may play pivotal roles in behavior changes among individuals experiencing long-term illness. This cross-sectional study included a sample of post-COVID-19 and non-COVID-19 subjects. We assessed the presence of psychiatric conditions utilizing standardized diagnostic criteria, Hamilton Rating Scale for Anxiety (HAM-A), Hamilton Rating Scale for Depression (HAM-D), Biological Rhythms in Neuropsychiatry Assessment Interview (BRIAN), and Functional Assessment Short Test (FAST). Plasma samples …

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Ai-Powered Education: A Cross-Country Exploration Of Ai Literacy Among Hospitality And Tourism Educators, Anderson Ngelambong, Siao Fui Wong, Silverina Kibat, Nur'hidayah Che Ahmat, Noel Scott Jun 2025

Ai-Powered Education: A Cross-Country Exploration Of Ai Literacy Among Hospitality And Tourism Educators, Anderson Ngelambong, Siao Fui Wong, Silverina Kibat, Nur'hidayah Che Ahmat, Noel Scott

Research outputs 2022 to 2026

While there is a growing acknowledgement of the importance of AI literacy in educational settings, there is a notable scarcity of specific studies focusing on the AI literacy levels of hospitality and tourism educators in the Asian region. Notably, this study explores the AI literacy levels and integration of AI technologies among hospitality and tourism educators. We interviewed 25 educators from Malaysia and China using a cross-country qualitative study approach to evaluate their mastery of AI tools, their integration of AI into their teaching, and their challenges. The results revealed notable differences in AI literacy between the two groups, with …

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The Density Of Virgin, Consumer And Environmental Plastics: An Investigation Using Gas Displacement Pycnometry, Andrew Turner, Katie Jones, Montserrat Filella Jun 2025

The Density Of Virgin, Consumer And Environmental Plastics: An Investigation Using Gas Displacement Pycnometry, Andrew Turner, Katie Jones, Montserrat Filella

School of Geography, Earth and Environmental Sciences

Density is a fundamental property of plastics and is particularly significant in determining the transport and fate of waste plastics that enter aquatic systems. However, densities are rarely determined in the environmental literature and values employed for modelling or impacts are often unsourced or derived from secondary databases. In this study, we employ helium displacement pycnometry to determine the skeletal densities of non-porous plastics whose polymer composition had been established from manufacturer's data, resin codes or Fourier transform infrared spectrometry. Two independent, collaborative laboratories, providing measurements within 3.5 % of each other and with precisions of <1 % (as relative standard deviation), analysed a total of 42 virgin, consumer and environmental plastics consisting of ten common polymer types. Measured densities of plastics in all categories, and most notably for polybutylene terephthalate, polyethylene terephthalate, polypropylene and polyvinyl chloride, were often outside the ranges reported by a comprehensive online resource. Possible reasons for discrepancies include the occurrence of dense additives (evaluated by X-ray fluorescence analysis), the presence of inaccessible microscopic pores below a laminated surface, contamination of the main polymer by a secondary one, and structural changes on weathering. Regardless of precise causes, most results suggest that individual polymers have a broader range of densities than is generally published or considered in the literature. Accordingly, and in particular where buoyancy is critical, more precise, sample-specific measurements are recommended.

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Handling Socio-Institutional Traps–Inertia Towards Australia’S Resilient International Development Aid Programs In The Solomon Islands, Mark Opoku Amankwa, Kwadwo Adusei-Asante, Alina Novak Jun 2025

Handling Socio-Institutional Traps–Inertia Towards Australia’S Resilient International Development Aid Programs In The Solomon Islands, Mark Opoku Amankwa, Kwadwo Adusei-Asante, Alina Novak

Research outputs 2022 to 2026

This study critically examines how donor’s aid delivery approach, entrenched socio-institutional dynamics, and the Solomon Islands’ complex political economy create persistent barriers to Australia’s aid programming. Through a desktop research approach, institutional trap–inertia theory is applied to analyze how Australia’s aid efforts and political structures perpetuate aid inertia. The study critiques both Australia’s aid delivery approach and the internal governance challenges in a cohesive society of the SI, highlighting their intertwined roles in impeding Australia’s aid programming. The article proffers context-driven, locally adaptive strategies aimed at overcoming institutional traps and fostering more resilient and effective aid interventions.

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Building Services Engineering May/June 2025 Jun 2025

Building Services Engineering May/June 2025

Building Services Engineering

No abstract provided.

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Mitigating Nonlinear Impairments In High-Speed Optical Communication Systems Via Volterra Nonlinear Equalizer, Safa Jabbar Mohammed, Jalil A. Hamadamin Jun 2025

Mitigating Nonlinear Impairments In High-Speed Optical Communication Systems Via Volterra Nonlinear Equalizer, Safa Jabbar Mohammed, Jalil A. Hamadamin

Polytechnic Journal

This paper presents an in-depth investigation into applying a frequency domain Volterra series nonlinear equalizer (FD-VNLE) to mitigate nonlinear impairments in optical communication systems operating at high speeds. The study aims to address the issues presented by nonlinear effects, specifically self-phase modulation (SPM), which significantly degrades system performance at higher power levels. A comprehensive mathematical model of the FD-VNLE was developed to provide theoretical insight, while its implementation was carried out using MATLAB co-simulated with OptiSystem. The performance of the 40 Gbps dual-polarization quadrature phase shift keying (DP-QPSK) system was rigorously evaluated, focusing on critical performance metrics like bit error …

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Investigation And Prediction Of Excessive Water Production In Bottom Water-Drive Naturally Fractured Reservoirs Using Machine And Deep Learning, Sami Abderraouf Belkhir Jun 2025

Investigation And Prediction Of Excessive Water Production In Bottom Water-Drive Naturally Fractured Reservoirs Using Machine And Deep Learning, Sami Abderraouf Belkhir

Theses

Naturally Fractured Reservoirs (NFRs) are characterized by dual-porosity and dual-permeability systems, posing significant challenges in managing water production due to highly conductive fracture networks that facilitate rapid water migration from bottom aquifers, often bypassing oil stored in the matrix, thus resulting in early water breakthrough and water channeling phenomena. The main objective of this thesis is to develop and validate deep learning and machine learning models to predict water production, water breakthrough time (tbt), and ultimate water cut (WCult) in NFRs, thereby enabling more effective reservoir management strategies. This work also aims to evaluate the sensitivity of water behavior to …

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Experimental Evaluation Of Novel Nano Polymer Hybrid Enhanced Oil Recovery In Carbonate Reservoir, Altamish Ahmed Pakeer Jun 2025

Experimental Evaluation Of Novel Nano Polymer Hybrid Enhanced Oil Recovery In Carbonate Reservoir, Altamish Ahmed Pakeer

Theses

Innovative enhanced oil recovery (EOR) strategies are needed to unlock additional reserves in heterogeneous, oil-wet carbonate reservoirs. This study evaluates hybrid nano-polymer flooding by integrating silica nanoparticles (SiO₂) and single-walled carbon nanotubes (CNT) with novel HPAM polymers (Sav10 and Sav10 VHM) to optimize wettability alteration, rheological parameters, and recovery mechanisms.

A comprehensive experimental approach was employed, where rheological tests assessed viscosity enhancement under varying shear conditions, and wettability alteration was quantified via contact angle measurements using HPAM-SiO₂, HPAM-CNT, Sav10 VHM-SiO₂, and Sav10 VHM-CNT systems. Core floods were performed in three consecutive phases; waterflooding (baseline), standalone nanoparticle flooding, and hybrid nano-polymer …

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Electrospun Membranes From Bio-Renewable Poly (Ethylene Furanoate)/Poly (Ethylene Teraphthalate) (Pef/Pet) Blend For Emulsification Application, Aya Ismat Sayed Jun 2025

Electrospun Membranes From Bio-Renewable Poly (Ethylene Furanoate)/Poly (Ethylene Teraphthalate) (Pef/Pet) Blend For Emulsification Application, Aya Ismat Sayed

Theses

This thesis focuses on manufacturing electrospun fibrous membranes from a blend of poly (ethylene terephthalate) and poly (ethylene furanoate) and using in premix emulsification. Poly (ethylene furanoate), which is a 100% bio-renewable polymer being blended with synthetic poly (ethylene terephthalate) for membrane fabrication contributes towards sustainability in the production of food and pharmaceutical emulsions. The primary objective of this research is to optimize the fabrication conditions of poly (ethylene terephthalate)/poly (ethylene furanoate) porous membranes, characterize their properties, and evaluate their performance in emulsification. This study compares poly (ethylene terephthalate) / poly (ethylene furanoate) blend membranes with individual poly (ethylene terephthalate) …

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How Mass Timber Supports Sustainability During Construction: An Industry-Based Analysis, Nicholas T. Mayton Jun 2025

How Mass Timber Supports Sustainability During Construction: An Industry-Based Analysis, Nicholas T. Mayton

Construction Management

As the construction industry explores new ways to reduce environmental impact, mass timber has emerged as a promising alternative to conventional materials. While much of the existing research on mass timber focuses on life-cycle assessments and carbon comparisons, few studies capture insights from professionals directly involved in building with it. This paper analyzes a series of industry interviews with contractors, designers, and sustainability consultants who have experience working on mass timber projects. The aim is to understand how sustainability plays out during the construction phase—not just in theory, but in practice. Using qualitative methods and word pattern analysis, three core …

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Assessing The Impact Of The Women In Construction Leadership Course And Disc Training On The Construction Industry For Students And Recent Graduates, Amanda E. Mcdowell Jun 2025

Assessing The Impact Of The Women In Construction Leadership Course And Disc Training On The Construction Industry For Students And Recent Graduates, Amanda E. Mcdowell

Construction Management

This study examined the impact of the Women in Construction Leadership Course, paired with DISC training, on students transitioning into the construction industry. The DISC instrument classifies behaviors into four personality types (i.e., Dominant, Influencer, Steady, Conscientious) and the training helped students identify each personality type to improve their communication skills. Although technical skills are essential for completing daily tasks, effective leadership and communication are crucial to project success. This research explored how DISC training can improve new hires’ perceptions of their abilities to interact and communicate with their project team members. Through a survey of course participants, the study …

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Assessing The Impact Of The Women In Construction Leadership Course And Disc Training On The Construction Industry For Students And Recent Graduates, Amanda E. Mcdowell Jun 2025

Assessing The Impact Of The Women In Construction Leadership Course And Disc Training On The Construction Industry For Students And Recent Graduates, Amanda E. Mcdowell

Construction Management

This study examined the impact of the Women in Construction Leadership Course, paired with DISC training, on students transitioning into the construction industry. The DISC instrument classifies behaviors into four personality types (i.e., Dominant, Influencer, Steady, Conscientious) and the training helped students identify each personality type to improve their communication skills. Although technical skills are essential for completing daily tasks, effective leadership and communication are crucial to project success. This research explored how DISC training can improve new hires’ perceptions of their abilities to interact and communicate with their project team members. Through a survey of course participants, the study …

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Biochar Suppresses Growth, Pupation And Eclosion Success Of A Specialist (Manduca Sexta) And A Generalist (Spodoptera Frugiperda) Insect Herbivore, Nischal Wagle, Soumya Unnikrishnan, Satinderpal Kaur, Engil Isadora Pujol Pereira, Rupesh R. Kariyat Jun 2025

Biochar Suppresses Growth, Pupation And Eclosion Success Of A Specialist (Manduca Sexta) And A Generalist (Spodoptera Frugiperda) Insect Herbivore, Nischal Wagle, Soumya Unnikrishnan, Satinderpal Kaur, Engil Isadora Pujol Pereira, Rupesh R. Kariyat

School of Earth, Environmental, & Marine Sciences Faculty Publications

Biochar is a charcoal-like substance made by the pyrolysis of organic material from agricultural and forestry waste. While biochar is well documented for altering soil physicochemical conditions, few studies have investigated its possible effects on the management of arthropod pests. Tobacco hornworm (Manduca sexta) and fall armyworm (Spodoptera frugiperda, FAW) are specialist and generalist insect herbivores respectively, that can cause significant defoliation in natural and agricultural ecosystems. In this study, we examined whether walnut shell biochar can affect growth and development of these herbivores. Specifically, we investigated how biochar influences parameters such as mass gain, length …

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Investigation Of Retention And Dehydration Of Preformed Particle Gel For Conformance Control In Fractured Carbonates, Abdulaziz A. Almakimi, Abdullah O. Almansour, Junchen Liu, Baojun Bai, Ibnelwaleed A. Hussein Jun 2025

Investigation Of Retention And Dehydration Of Preformed Particle Gel For Conformance Control In Fractured Carbonates, Abdulaziz A. Almakimi, Abdullah O. Almansour, Junchen Liu, Baojun Bai, Ibnelwaleed A. Hussein

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Preformed particle gel (PPG) treatment has proved to be among the most effective methods to reduce excessive water production in fractured reservoirs. The blocking ability of PPGs to fractures or fracture-like features is highly dependent on injected gel properties and volume. Gel dehydration during extrusion through fracture is common and has a considerable effect on gel properties, transport, and plugging efficiency. As the gel particles propagate through the fracture, continuous dehydration is often associated and causes the gel to concentrate and require high-pressure gradients to move. Dehydration might be desirable to a certain limit because it can help to form …

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Sails Symposium Launch On International Law Scholarship: What We Write, Where We Publish, And Why It Matters, Kathleen Claussen, Melissa J. Durkee, Rebecca Ingber, Steven Arrigg Koh Jun 2025

Sails Symposium Launch On International Law Scholarship: What We Write, Where We Publish, And Why It Matters, Kathleen Claussen, Melissa J. Durkee, Rebecca Ingber, Steven Arrigg Koh

Faculty Scholarship

Despite the centrality of international law scholarship in international law, little work has been done to understand the contours and forces at work in what international law scholars write, where they publish that work, who reads international law scholarship, and scholarship's relationship to the policy world. For international lawyers, identifying answers to these questions and appreciating the impact of our collective work is essential, particularly at a moment of profound political struggle in communities around the world. We have remarkably few data as to what topics, methodologies, and perspectives of international law scholarship journals and publishers print, by whom, in …

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Revisiting “Mandatory Mediation: An Oxymoron?” Advancing Access To Civil Justice Through Mandatory Adr, Dorcas Quek Anderson Jun 2025

Revisiting “Mandatory Mediation: An Oxymoron?” Advancing Access To Civil Justice Through Mandatory Adr, Dorcas Quek Anderson

Research Collection Yong Pung How School Of Law

Access to civil justice, a concept integral to the rule of law, has been an enduring concern in many countries. One prominent strategy to enhance access to civil justice entails the use of alternative dispute resolution (ADR) methods prior to court adjudication. In this regard, efforts to embed ADR within the court system have intensified in both England and Wales and Singapore. In Singapore, the parties have a duty to consider ADR prior to and during civil proceedings. More significantly, the courts have been empowered to order parties to attempt ADR. In a similar vein, the English Court of Appeal …

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Ai Governance And Algorithmic Auditing In Financial Institutions: Lessons From Singapore, Nydia Remolina Leon Jun 2025

Ai Governance And Algorithmic Auditing In Financial Institutions: Lessons From Singapore, Nydia Remolina Leon

Research Collection Yong Pung How School Of Law

This paper examines the role of algorithmic auditing as a mechanism for responsible AI development and deployment in the financial sector, with a particular focus on Singapore’s regulatory and institutional initiatives. Against the backdrop of fragmented global artificial intelligence (AI) governance frameworks, the study analyses how Singapore has developed operational tools — such as the Veritas Toolkit, AI Verify, Project Moonshot and Project Mindforge — that go beyond abstract ethical principles to provide measurable, use-case-specific standards for auditing AI systems. These initiatives contribute to standardising audit practices, enhancing transparency and bridging trust gaps between financial institutions, regulators and stakeholders. The …

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‘Making A Positive Environmental Impact’: Exploring The Role Of Volunteering At A Campus Community Garden, Dina Izenstark, Barbara Ann Boone Jun 2025

‘Making A Positive Environmental Impact’: Exploring The Role Of Volunteering At A Campus Community Garden, Dina Izenstark, Barbara Ann Boone

Faculty Research, Scholarly, and Creative Activity

Promoting sustainability in higher education is a social and environmental imperative. This paper explores how and why volunteering at a campus community garden (CCG) can serve as a unique context for promoting sustainability. Twenty-five undergraduate students between the ages of 18 and 27, who had volunteered at a campus garden, participated in individual semi-structured interviews. A majority of participants identified as female (80%) and Asian American (52%). Using reflexive thematic analysis, we first found students were motivated to volunteer for personal and academic reasons as well as to learn more about gardening. Childhood gardening experiences influenced participants’ re-engagement as adults. …

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In Vitro Comparison Of Two Python-Based Programs For The Automated Analysis Of Tight-Junction Phenotype In Brain Endothelium During Bacterial Infection, Henry D. Mauser, Janessa Caroza, Shane Nicole Homez, Alyssa S. Arnett, William D. Cutts, Daryl W. Lam, Justin Thornton, Walter Adams, Brandon J. Kim Jun 2025

In Vitro Comparison Of Two Python-Based Programs For The Automated Analysis Of Tight-Junction Phenotype In Brain Endothelium During Bacterial Infection, Henry D. Mauser, Janessa Caroza, Shane Nicole Homez, Alyssa S. Arnett, William D. Cutts, Daryl W. Lam, Justin Thornton, Walter Adams, Brandon J. Kim

Faculty Research, Scholarly, and Creative Activity

Tight junction complexes are crucial features of brain endothelial cells, as they restrict the paracellular route across the blood–brain barrier. Tight junction disruption has been observed in conjunction with numerous diseases of the CNS. In such cases, the organization or integrity of cell–cell junctions may be analyzed with a variety of automated computer programs that quantitatively assess junction images. Here, we directly compare two previously developed python-based programs—JAnaP and IJOQ— for the semi- or fully automated analysis of tight junctions in human stem cell-derived brain-like endothelial cells. Cells were infected with S. pneumoniae and S. agalactiae to initiate junction disruption, …

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Development Of An Hplc-Light Scattering Method For The Quantification Of Dicyclohexylamine In Beeswax, Joseph J. Pesek, Maria T. Matyska-Pesek, Tanya Hiltz, Jason Hall Jun 2025

Development Of An Hplc-Light Scattering Method For The Quantification Of Dicyclohexylamine In Beeswax, Joseph J. Pesek, Maria T. Matyska-Pesek, Tanya Hiltz, Jason Hall

Faculty Research, Scholarly, and Creative Activity

An excipient present in commercial formulations of fumagillin (an antibiotic used in apiculture for the control of Nosema disease) toxic dicyclohexylamine is found in beeswax samples. There is a need for a reliable analytical method without the use of MS for analysis of this compound. A reversed-phase gradient method was developed for the analysis using a simple extraction procedure followed by low temperature elimination of interfering compounds. Since dicyclohexylamine is lacking a chromophore, an evaporative light scatter detector was used in this analysis. Several challenges of quantitative analysis using an evaporative light scatter detector were addressed. The reported method was …

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The ‘Double-Exposure’ Of Riverine Communities In Northeast India To Dams And Climate Change, Costanza Rampini Jun 2025

The ‘Double-Exposure’ Of Riverine Communities In Northeast India To Dams And Climate Change, Costanza Rampini

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

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Engineering Microphysiological Systems To Investigate Cellular Responses To Biophysical Cues In Human Tissue Microenvironments, Mehran Mansouri Jun 2025

Engineering Microphysiological Systems To Investigate Cellular Responses To Biophysical Cues In Human Tissue Microenvironments, Mehran Mansouri

Theses

Cells constantly sense and respond to biophysical cues in their microenvironment. Understanding how they interpret these mechanical signals is essential for advancing tissue modeling, studying disease mechanisms, and developing more predictive in vitro platforms. This dissertation presents a series of engineered microphysiological systems (MPS) designed to investigate how mechanical stimuli shape cellular behavior in distinct human tissue microenvironments. In Aim 1, I developed a reconfigurable microfluidic platform that mimics key features of human vascular barriers. This system supports the integration of porous membranes, 3D hydrogels, and flow channels, enabling precise control over both mechanical and biochemical cues. The modularity of …

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Modeling Femtosecond Laser Interaction With Glass For Optical Fabrication, Nathan Klein Jun 2025

Modeling Femtosecond Laser Interaction With Glass For Optical Fabrication, Nathan Klein

Theses

The fabrication of precision optics is critical for a wide range of applications, including biosensors, virtual and augmented reality, medical imaging, and micro-electronics. However, it is challenging to meet the demands of these applications with conventional chemical and mechanical fabrication methods, as they can introduce chemical waste, mid-spatial-frequency errors, and subsurface damage that degrades image quality. Femtosecond lasers have emerged as a promising alternative, offering fast, non-contact, and chemical-free machining with single digit nanometer precision. This thesis presents a computational model designed to investigate the interaction process between a high-intensity femtosecond laser pulse and dielectric material. A pulse propagation model …

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When Does Anxiety Increase Attempts To Spend Time And Money Efficiently?, Shruti Koley, Caleb Warren, Suresh Ramanathan Jun 2025

When Does Anxiety Increase Attempts To Spend Time And Money Efficiently?, Shruti Koley, Caleb Warren, Suresh Ramanathan

Business Faculty Publications and Presentations

Consumers today are anxious. How does this anxiety influence how they spend their time and money? Five experiments demonstrate that when consumers feel anxious because they are making insufficient progress toward a goal, they attempt to use their resources more efficiently while making decisions unrelated to the goal. This desire to be efficient makes them more likely to (a) choose jobs that offer higher payout rates rather than a higher total payout, (b) perform tasks simultaneously rather than sequentially (i.e., multitask), and (c) select products and activities that cost less money and time than usual (i.e., price and time discounts). …

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Dean's Update, June 2025, Neil W. Schluger Jun 2025

Dean's Update, June 2025, Neil W. Schluger

SOM Dean's Research Newsletter

No abstract provided.

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A Vacuolar Proton Pump Controls The Post-Germinative Growth Of Rice (Oryza Sativa Ssp. Japonica), Peter James Icalia Gann, Soumen Nandy, Rodrigo Botelho, Kari Vinzant, Mariya Khodakovskaya, Vibha Srivastava Jun 2025

A Vacuolar Proton Pump Controls The Post-Germinative Growth Of Rice (Oryza Sativa Ssp. Japonica), Peter James Icalia Gann, Soumen Nandy, Rodrigo Botelho, Kari Vinzant, Mariya Khodakovskaya, Vibha Srivastava

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Post-germinative growth in plants is controlled by sucrose mobilization from the endosperm. Regulation of this process, however, is not fully understood. Transcriptional suppression of the rice vacuolar H+ translocating pyrophosphatase (V-PPase) referred to as VPP5 led to enhanced starch content in mature grains. However, vpp5 suppressed lines displayed a slower post-germinative growth rescuable by sucrose, indicating inefficient sucrose mobilization from the endosperm. Biochemical and gene expression analyses showed a slower rate of starch to sucrose conversion and altered expression of the key starch utilization pathway genes. We hypothesized that the modulation of metabolic activities in the vpp5 lines was based …

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