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Cardozo Law News Brief: July 11, 2025, Benjamin N. Cardozo School Of Law Jul 2025

Cardozo Law News Brief: July 11, 2025, Benjamin N. Cardozo School Of Law

Cardozo Law News Briefs

This Cardozo Law News Brief highlights the school’s 10th annual Pride Brunch, where students and alumni gathered to celebrate Cardozo’s LGBTQ+ community while watching the NYC Pride March. It also features a major Immigration Justice Clinic court victory advancing transparency in ICE procedures, with students playing a central role in the case. In the media, Professor Jacob Noti-Victor spoke to WIRED about Meta’s win in a landmark AI copyright case, and Professor Haiyun Damon-Feng was quoted in Law360 on the Supreme Court’s decision limiting universal injunctions. Additional scholarship news includes Professors Matthew Wansley and Samuel Weinstein’s co-authored article No Exit …


Oral Dosing Of The Nucleoside Analog Obeldesivir Is Efficacious Against Rsv Infection In African Green Monkeys, Jared Pitts, J Lizbeth Reyes Zamora, Savrina Manhas, Thomas Aeschbacher, Josolyn Chan, Vincent Cutillas, Varsha Nair, Nicholas C Riola, Arya Vijjapurapu, Meghan S Vermillion, Stacey Eng, Christopher Richards, Dong Han, Jason K Perry, Subhra Chaudhuri, Szu-Wen Liu, Clarissa Martinez, Nadine Peinovich, Kai-Hui Sun, Arthur Cai, Ross Martin, Jasmine Moshiri, Charlotte Hedskog, Darius Babusis, Dustin S Siegel, Rao Kalla, Vasanthi Avadhanula, Pedro A Piedra, Kim Stobbelaar, Peter L Delputte, Caleb Marceau, Roberto Mateo, Evguenia Maiorova, Hongmei Mo, Raju Subramanian, Richard L Mackman, Tomas Cihlar, Simon P Fletcher, John P Bilello Jul 2025

Oral Dosing Of The Nucleoside Analog Obeldesivir Is Efficacious Against Rsv Infection In African Green Monkeys, Jared Pitts, J Lizbeth Reyes Zamora, Savrina Manhas, Thomas Aeschbacher, Josolyn Chan, Vincent Cutillas, Varsha Nair, Nicholas C Riola, Arya Vijjapurapu, Meghan S Vermillion, Stacey Eng, Christopher Richards, Dong Han, Jason K Perry, Subhra Chaudhuri, Szu-Wen Liu, Clarissa Martinez, Nadine Peinovich, Kai-Hui Sun, Arthur Cai, Ross Martin, Jasmine Moshiri, Charlotte Hedskog, Darius Babusis, Dustin S Siegel, Rao Kalla, Vasanthi Avadhanula, Pedro A Piedra, Kim Stobbelaar, Peter L Delputte, Caleb Marceau, Roberto Mateo, Evguenia Maiorova, Hongmei Mo, Raju Subramanian, Richard L Mackman, Tomas Cihlar, Simon P Fletcher, John P Bilello

Faculty, Staff and Students Publications

Respiratory syncytial virus (RSV) is a significant cause of morbidity and mortality in high-risk populations. Although prophylactic options are available, there are no effective oral therapeutics for RSV infection. Obeldesivir (ODV) is an orally bioavailable prodrug of the nucleoside analog GS-441524, which is converted intracellularly to its active nucleoside triphosphate and inhibits the RSV RNA polymerase. Here we report the potent antiviral activity of ODV against geographically and temporally diverse RSV A and B clinical isolates (EC50: 0.20–0.66 μM). Resistance selection studies with ODV and GS-441524 against RSV identify a single amino acid substitution, I777L, in the L polymerase with …


Effects Of Seasonality On The Experiences Of Employees In Minor League Sports, Amanda Barefoot Jul 2025

Effects Of Seasonality On The Experiences Of Employees In Minor League Sports, Amanda Barefoot

LSU Doctoral Dissertations

The temporal rhythms of sport organizations, driven by recurring cycles of in-season and off-season activity, create a unique organizational context that shapes decision-making, leadership behavior, and the experiences of employees. While seasonality is widely recognized in operational planning and revenue forecasting, its implications for organizational behavior in sport management remain underexplored. This three-paper dissertation examines seasonality as a temporal force influencing sport organizations at conceptual, strategic, and affective levels.

The first paper develops a sport-specific taxonomy of seasonality by synthesizing literature from econometrics, tourism, and organizational theory. It distinguishes between natural, internally institutionalized, and externally institutionalized seasonal influences, offering a …


Rank-Based Secure Multi-Ai Agent Communication System For Misinformation Prevention, Sree Gowri Addepalli, Sushma Mahadevaswamy, Arica Schivonne Jackson, Barry Qi Yuan Jul 2025

Rank-Based Secure Multi-Ai Agent Communication System For Misinformation Prevention, Sree Gowri Addepalli, Sushma Mahadevaswamy, Arica Schivonne Jackson, Barry Qi Yuan

Defensive Publications Series

This submission introduces a novel approach to prevent the generation of artificial intelligence (AI) misinformation by proposing rank-based multi-AI agent communication with novel dynamic parameter adaptive re-ranking technique based on various security behavioral metrics and data recency. This approach provides the ability to minimize the spread of outdated information or misinformation, ensuring more trustworthy outputs from AI systems.


A Learning Plan On The Understanding Of Abo Blood Group Compatibility, Ermor Francisco-Martizano Jul 2025

A Learning Plan On The Understanding Of Abo Blood Group Compatibility, Ermor Francisco-Martizano

Annual Research Congress for High School and Elementary Teachers, Researchers, and Scholars (ARCHERS)

This learning plan is designed to gain a better understanding of ABO blood group compatibility, including how blood types are determined, their importance, and how they affect blood transfusions and organ transplants. The following objectives outline the specific objectives to be accomplished by the end of the lesson:

A. identify the different blood types and their characteristics;

B. understand the importance of ABO blood group compatibility in blood transfusions and organ transplants;

C. enumerate the consequences of incompatible blood transfusions and organ transplants;

D. demonstrate blood typing techniques to know ABO blood compatibility.

The goals above are aligned with the …


"Female Faithfulness Encouraged": Gendered Piety In Early American Print, Kadienne Sizemore Jul 2025

"Female Faithfulness Encouraged": Gendered Piety In Early American Print, Kadienne Sizemore

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Following the American Revolution, membership in Baptist churches grew exponentially and the influence of the Baptist persuasion was significant. As one of the fastest growing Protestant denominations in early America, Baptists and their interests were often indicative of larger trends in religiosity. Conceptions of piety, including beliefs surrounding submission, faithfulness, and duty, were central to the structure of Baptist congregations and their proximate communities. This paper explores the role of gender in the discussion, presentation, and justification of Baptist notions of piety in their publications during the Early American Republic. To build on the work of historians exploring female autonomy …


Savoring The Seaweeds: Health And Sustainability Through Creole Foods, Roxanna Belleau Jul 2025

Savoring The Seaweeds: Health And Sustainability Through Creole Foods, Roxanna Belleau

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Incorporating kelp into American diets offers a promising avenue for enhancing nutrition and environmental sustainability. Despite its nutritional richness and ecological benefits as a "superfood" and carbon sink, cultural resistance presents a barrier to its widespread acceptance. This study delves into kelp's nutritional content and ecological advantages, exploring its potential to reshape dietary habits. Drawing insights from interviews and surveys, cultural norms emerge as a significant obstacle to kelp's integration into American cuisine. Strategies inspired by successful culinary adaptations, such as creole dishes, are proposed to navigate these challenges and shift societal perceptions. Furthermore, integrating kelp into familiar American foods …


How Could You [Book Review], Sierra Schuman Jul 2025

How Could You [Book Review], Sierra Schuman

Disability in LIS (DisLIS)

This book review will cover How Could You, the debut graphic novel by Ren Strapp. Although disability is not the main focus of this graphic novel, disability depiction is discussed, alongside the art style, overall narrative, and queer representation.


New Approaches To Media Education Jul 2025

New Approaches To Media Education

Communication Research Trends

There is increasing consensus among educators around the world that some form of education for the use of the public media - especially television - should be an integral part of the primary and secondary school education.

Teachers are daily experiencing the fact that one of the major cultural influences forming the imagination of their students is the often long hours watching television. Sometimes television is a more important 'educational experience' than the school. Too often, however, the school, family life and the· television set are three mutually antagonistic or indifferent poles that leave young people drifting in a no …


The Challenge Of Cable Television Jul 2025

The Challenge Of Cable Television

Communication Research Trends

Cable television is at least thirty years old, yet it is still talked of as a new communications medium. Why? Optimists say because it has yet to realise its multi-channel potential to enrich and diversify television programming. Even better, cable will provide the citizen with a host of interactive information, educational, and transaction services.

Sceptics see cable offering old programming in new packages. They ask: Will only the well-off benefit? Who will control cable systems? Can privacy be protected? Does cable TV damage public service broadcasting? What do we really want cable for?

In many countries cable is on the …


Critical Reviews Of Advertising Jul 2025

Critical Reviews Of Advertising

Communication Research Trends

In the late 1950s and early 1960s a series of very influential thinkers began a strong movement of criticism of advertising. This questioning of advertising led to a deeper questioning of the 'cult of consumerism' which advertising propagates.

Vance Packard in his popular book, The Hidden Persuaders (1956) attacked advertising for using the techniques of depth psychology to raise 'subliminal anxieties' and manipulate desires for alcohol, cigarettes and other consumer items. John Kenneth Galbraith, in The Affluent Society (1958) pointed out that advertising was encouraging a wasteful consumerism which allowed a small portion of the world's people to use up …


The Tax Adviser, Volume 11, Number 8, August 1980, American Institute Of Certified Public Accountants Jul 2025

The Tax Adviser, Volume 11, Number 8, August 1980, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.


Insurance Companies And The Income Tax: Legislative Developments, Gordon O. Pehrson, Carolyn P. Chiechi, John T. Adney Jul 2025

Insurance Companies And The Income Tax: Legislative Developments, Gordon O. Pehrson, Carolyn P. Chiechi, John T. Adney

Tax Adviser

No abstract provided.


Niche Conservatism And Sympatric Parallel Evolution May Help To Maintain Eight Nascent Tree Taxa Along A Sharp Elevation Gradient, Elizabeth A. Stacy, Rebecca Ostertag Jul 2025

Niche Conservatism And Sympatric Parallel Evolution May Help To Maintain Eight Nascent Tree Taxa Along A Sharp Elevation Gradient, Elizabeth A. Stacy, Rebecca Ostertag

Life Sciences Faculty Research

  1. Patterns of niche partitioning among closely related taxa, such as those in incipient adaptive radiations, can provide clues into how niches are created, partitioned, and integrated over ecological and evolutionary time scales. Hawaiian Metrosideros is a ~3-MYO adaptive radiation of trees that dominates the Hawaiian Islands in continuous stands within islands and allows examination of niche partitioning at the early stages of adaptive radiation.
  2. We monitored growth and survivorship over 2 years of seedlings derived from open-pollinated fruits of eight Metrosideros taxa distributed along the elevation gradient of Koʻolau Volcano, Oʻahu, under four combinations of light and phosphorus. We included …


Corrosion Behavior Of Mgtizn And Mg4tizn Alloys After Ball Milling And Subsequent Spark Plasma Sintering, Alexander Helmer, Rahul Agrawal, Manoj Mugale, Tushar Borkar, Rajeev Gupta Jul 2025

Corrosion Behavior Of Mgtizn And Mg4tizn Alloys After Ball Milling And Subsequent Spark Plasma Sintering, Alexander Helmer, Rahul Agrawal, Manoj Mugale, Tushar Borkar, Rajeev Gupta

Mechanical Engineering Faculty Publications

Magnesium-containing multi-principal element alloys (MPEAs) are promising for lightweight applications due to their low density, high specific strength, and biocompatibility. This study examines two Mg-Ti-Zn alloy compositions, equal molar MgTiZn (TZ) and Mg4TiZn (4TZ), synthesized via ball milling followed by spark plasma sintering, focusing on their microstructures and corrosion behaviors. X-ray diffraction and transmission electron microscopy revealed the formation of intermetallic phases, including Ti2Zn and Mg21Zn25 in TZ, while 4TZ exhibited a predominantly Mg-rich phase. Potentiodynamic polarization and immersion tests in 0.1 M NaCl solution showed that both alloys had good corrosion resistance, with values of 3.65 +/- 0.65 mu …


Dames At Sea, Otterbein Theatre And Dance Department Jul 2025

Dames At Sea, Otterbein Theatre And Dance Department

2025 Summer Theatre

No abstract provided.


Pantun As A Medium For Environmental Education And Ecological-Political Activism By Customary Institutions In Haruku Island, Diah Meutia Harum, Sabara Sabara, Helmina Kastanya, Devi Fauziyah Ma'rifat, Selvone Christin Pattiserlihun, Andi Alfian, Vikry Reinaldo Paais Jul 2025

Pantun As A Medium For Environmental Education And Ecological-Political Activism By Customary Institutions In Haruku Island, Diah Meutia Harum, Sabara Sabara, Helmina Kastanya, Devi Fauziyah Ma'rifat, Selvone Christin Pattiserlihun, Andi Alfian, Vikry Reinaldo Paais

Forest and Society

This research aims to examine the ecological values and political practice contained in pantun, particularly that used by the kewang, a customary or adat institution in Haruku Village, Central Maluku. In Haruku, pantun is used as a medium of enviromental education and ecological activism for the community, specifically the young generation. This study is expected to contribute to the reconstruction of a more eco-friendly civilization of the Archipelago by streamlining the potential of local traditions in promoting sustainability andconservation Haruku Village, in this study, becomes a role model and best practice of utilizing kewang as a customary institution, …


Rhetoric And Reality: The P&O Ferries Scandal And The Right To Strike, Alan Bogg Jul 2025

Rhetoric And Reality: The P&O Ferries Scandal And The Right To Strike, Alan Bogg

Comparative Labor Law & Policy Journal

This article considers the freedom of association implications of the mass dismissals at P&O Ferries in 2022, in light of the Committee on Freedom of Association’s recent consideration of a complaint by affected trade unions. It identifies an important strategic shift in British trade unions’ engagement with legal enforcement. This involves an attenuation of the strong historical attachment to “voluntarism” in British industrial relations. It then considers some legal implications of the P&O Ferries scandal under the European Convention on Human Rights. It concludes by identifying a phenomenon of “state-managed deregulation” in the maritime sector, whereby company de-collectivization is facilitated …


Re: Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) 2024 Draft Final Backfill And Cover Material Quality Assurance Project Plan (Dated September 27, 2024), Molly Roby Jul 2025

Re: Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) 2024 Draft Final Backfill And Cover Material Quality Assurance Project Plan (Dated September 27, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Signifying The End Of Swidden? An Analysis Of Vocabulary Of The Fallow Stage Among A Kalimantan Indigenous Group, Indonesia, Syamsul Rijal, Muhammad Hasyim, Lukman Lukman, Ery Iswary Jul 2025

Signifying The End Of Swidden? An Analysis Of Vocabulary Of The Fallow Stage Among A Kalimantan Indigenous Group, Indonesia, Syamsul Rijal, Muhammad Hasyim, Lukman Lukman, Ery Iswary

Forest and Society

This study examines how the Dayak Tunjung community in East Kalimantan, Indonesia, employs linguistic classifications to structure and transmit ecological knowledge within a traditional swidden agricultural system. It focuses on the vocabulary used to denote fallow stages and analyzes how generational shifts in language use reflect broader socio-ecological transformations. Data were collected through 16 semi-structured interviews and participant observation in Linggang Melapeh Village, stratified by age and occupation to capture intergenerational dynamics. The findings reveal that older generations retain a detailed lexicon tied to ecological succession and customary land practices, while younger members increasingly adopt shortened fallow cycles and show …


Impacts Of Urbanization On The Use Of Soil Amendments By Rice Farmers Along A Rural-Urban Continuum In Northeast Thailand, Sujitra Yodda, Suwit Laohasiriwong, Phrueksa Lawongsa, Tanabhat-Sakorn Sukitprapanon, A. Terry Rambo Jul 2025

Impacts Of Urbanization On The Use Of Soil Amendments By Rice Farmers Along A Rural-Urban Continuum In Northeast Thailand, Sujitra Yodda, Suwit Laohasiriwong, Phrueksa Lawongsa, Tanabhat-Sakorn Sukitprapanon, A. Terry Rambo

Forest and Society

This study investigated the impact of urbanization on use of soil amendment by rice farmers in three villages along a rural–urban continuum in Northeast Thailand. It shows how urbanization influences their use of types and quantities of soil amendments. Data were collected by interviewing 150 farmers, focusing on types, quantities, sources, costs, and perceived effects of nine different amendments, including rice straw, chemical fertilizers, manures, and green manure. Results revealed significant declines in organic amendment use as villages become more urbanized, with rural farmers employing more diverse and greater quantities of organic amendments while periurban and urban farmers predominantly rely …


The Impact Of Entrepreneurial Orientation On Innovation Performance: The Role Of Knowledge Sharing As A Mediating Factor, Dhia Qasim, Ahmed Shuhaiber, Zainab Rawshdeh Jul 2025

The Impact Of Entrepreneurial Orientation On Innovation Performance: The Role Of Knowledge Sharing As A Mediating Factor, Dhia Qasim, Ahmed Shuhaiber, Zainab Rawshdeh

All Works

Innovation is critical for enhancing business products and processes, leading to improved overall performance for firms. Knowledge sharing (KS) plays a crucial role in fostering innovation within firms. Literature has addressed entrepreneurial orientation (EO) and innovation performance (IP) in firms; however, extant literature has not considered the influence of EO on IP in emerging economies. Thus, based on the EO theory, this paper develops a theoretical framework to investigate the influence of EO antecedents on IP within the mediating role of KS. Data were collected from three national telecom companies in Jordan, and 215 responses were analyzed using partial least …


Constructing Victims And Perpetrators: A Textual Analysis Of Media Discourses On Sexual Violence, Farah Ali Jul 2025

Constructing Victims And Perpetrators: A Textual Analysis Of Media Discourses On Sexual Violence, Farah Ali

Global Language Studies Faculty publications

Sexual violence has become increasingly visible in the public eye, which has in turn prompted scholarly research across disciplines to critically examine how such cases are handled, ranging from the investigation processes to how the accused and accusing parties are impacted. Linguistic research in particular has made an important contribution to our understanding of the role of language in interpreting and evaluating sexual violence by focusing on the narrations of specific cases. Yet linguistic perspectives are somewhat sparse with regard to mass media discourse, which can play an influential role in shaping discussions on sexual violence. This study examines discourse …


Salinity And Moisture Influence Co2 And Ch4 Emissions From High-Latitude Coastal Soils, B. N. Barr, K. C. Kelsey, A. J. Leffler, M. Petit Bon, K. H. Beard Jul 2025

Salinity And Moisture Influence Co2 And Ch4 Emissions From High-Latitude Coastal Soils, B. N. Barr, K. C. Kelsey, A. J. Leffler, M. Petit Bon, K. H. Beard

Wildland Resources Faculty Publications

Sea level rise and more frequent and larger storms will increase saltwater flooding in coastal terrestrial ecosystems, altering soil-atmosphere CO2 and CH4 exchange. Understanding these impacts is particularly relevant in high-latitude coastal soils that hold large carbon stocks but where the interaction of salinity and moisture on greenhouse gas flux remains unexplored. Here, we quantified the effects of salinity and moisture on CO2 and CH4 fluxes from low-Arctic coastal soils from three landscape positions (two Wetlands and Upland Tundra) distinguished by elevation, flooding frequency, soil characteristics, and vegetation. We used a full factorial laboratory incubation experiment …


Missing Information: A Content Analysis Of U.S. Missing Persons Alerts Using The Missing And Endangered Persons Message Framework, Lauren Cain, Jeannette Sutton, Hugh Walpole, Micki Olson Jul 2025

Missing Information: A Content Analysis Of U.S. Missing Persons Alerts Using The Missing And Endangered Persons Message Framework, Lauren Cain, Jeannette Sutton, Hugh Walpole, Micki Olson

Emergency Preparedness, Homeland Security, and Cybersecurity Faculty Scholarship

Missing and endangered person (MEP) alerts are a prominent messaging strategy used by law enforcement agencies in the United States to recover missing persons, with over 1,800 AMBER Alerts issued via the Wireless Emergency Alert (WEA) system and nearly 40 similar alerts introduced by state legislatures for other groups of missing people. Despite their prevalent use, the contents of MEP alerts have not yet been empirically examined. Drawing from warning message design and AMBER Alert best practices, we propose a new MEP Message Framework and use it to evaluate the contents of 4,053 MEP WEAs sent from 2013 to 2023. …


Integrase-Deficient Lentiviral Vector As A Platform For Efficient Crispr/Cas9-Mediated Gene Editing For Mucopolysaccharidosis Iva, Fnu Nidhi, Shunji Tomatsu Jul 2025

Integrase-Deficient Lentiviral Vector As A Platform For Efficient Crispr/Cas9-Mediated Gene Editing For Mucopolysaccharidosis Iva, Fnu Nidhi, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disorder causing systemic skeletal dysplasia due to a deficiency of N-acetyl-galactosamine-6-sulfate sulfatase (GALNS) enzyme activity, leading to the impaired degradation and accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate. While treatments such as enzyme replacement therapy (ERT) and hematopoietic stem cell transplantation (HSCT) are available, they have significant limitations regarding efficacy in skeletal tissues and long-term safety, highlighting the need for more effective therapies. We evaluated a novel gene therapy approach using a dual Integrase-deficient lentiviral vector (IDLV) to deliver an expression cassette that includes human GALNS cDNA and Cas9 sgRNA, …


Groo V. Montana Eleventh Judicial District Court: Montana’S Long-Arm Overreaches Into Cyberspace, Matthew Belle Jul 2025

Groo V. Montana Eleventh Judicial District Court: Montana’S Long-Arm Overreaches Into Cyberspace, Matthew Belle

Montana Law Review

No abstract provided.


The Indigenous Land Struggles Amidst The Pressures For Change In The Lake Toba Areas Of North Sumatra, Indonesia, Betty B. S. Naibaho, Shew-Jiuan Su Jul 2025

The Indigenous Land Struggles Amidst The Pressures For Change In The Lake Toba Areas Of North Sumatra, Indonesia, Betty B. S. Naibaho, Shew-Jiuan Su

Forest and Society

Many Masyarakat Adat (Indigenous People), including those in the Lake Toba areas of North Sumatra, Indonesia, struggle to protect their rights to land and resources. This article examines the agencies and dynamics of indigenous-land-related development in Lake Toba amidst modernization, focusing on their roles, relationships, perceptions, interests, and strategies. Semi-structured interviews using snowball sampling were conducted with Indigenous People around Lake Toba, local NGOs, and local government representatives. Five key groups were identified in the process of procuring Indigenous land use rights for the Toba Batak ethnic group: tribal leaders (elders), community members, land dealers, local government, and NGOs. The …


The Guardian Of East Borneo: Indigenous Women In Gender Equality, Local Culture, And Language Preservation In The Surrounded Area Of Indonesia's New Capital City, Famala Eka Sanhadi Rahayu, Nita Maya Valiantien, Alamsyah Alamsyah, Setya Ariani, Ester Lina Jul 2025

The Guardian Of East Borneo: Indigenous Women In Gender Equality, Local Culture, And Language Preservation In The Surrounded Area Of Indonesia's New Capital City, Famala Eka Sanhadi Rahayu, Nita Maya Valiantien, Alamsyah Alamsyah, Setya Ariani, Ester Lina

Forest and Society

This research aims to reveal the position of indigenous women in Indonesia’s capital city in terms of gender equality, culture, and local language preservation. The research is done through semi-structured interviews and analyzed using a phenomenological approach. There are 19 participants selected from two indigenous ethnicities: Dayak, and Paser. The participants reveal that gender equality has long been applied in their community, which can be seen from the equality of education, jobs, domestic affairs, rituals, and representation in government or organization. Furthermore, the findings demonstrate the crucial role of women in preserving culture and language, as they serve as initiators, …


Receptor-Mediated Spion Labeling Of Cd4+ T Cells For Longitudinal Mri Tracking Of Distribution Following Systemic Injection In Mouse, Yu Ping, Songyue Han, Brock Howerton, Francesc Marti, Jake Weeks, Roberto Gedaly, Reuben Adatorwovor, Fanny Chapelin Jul 2025

Receptor-Mediated Spion Labeling Of Cd4+ T Cells For Longitudinal Mri Tracking Of Distribution Following Systemic Injection In Mouse, Yu Ping, Songyue Han, Brock Howerton, Francesc Marti, Jake Weeks, Roberto Gedaly, Reuben Adatorwovor, Fanny Chapelin

Surgery Faculty Publications

Tracking T cells in vivo using MRI is a major challenge due to the difficulty of labeling these non-phagocytic cells with a sufficient contrast agent to generate a detectable signal change. In this study, we explored CD4-Superparamagnetic iron oxide nanoparticles (SPION), which is commonly used in magnetic cell sorting, as a potential receptor-mediated, specific CD4+ T cell MRI labeling agent. We optimized the labeling protocol for maximal CD4+ cell labeling and viability. Cell health was confirmed with trypan blue assay, and labeling efficacy was confirmed with Prussian blue staining, transmission electron microscopy, and MRI of labeled cell pellets. Key cell …