Digital Commons Network^™

Feasibility Of Manufacturing And Antitumor Activity Of Til For Advanced Endometrial Cancers, Yongliang Zhang, Kathleen N Moore, Amir A Jazaeri, Judy Fang, Ilabahen Patel, Andrew Yuhas, Patrick Innamarato, Nathan Gilbert, Joseph W Dean, Behzad Damirchi, Joe Yglesias, Rongsu Qi, Michelle R Simpson-Abelson, Erwin Cammaart, Sean R R Hall, Hequn Yin

Faculty, Staff and Student Publications

Lifileucel, a tumor-infiltrating lymphocyte (TIL) cell therapy approved for advanced melanoma, demonstrates promise for treating other solid tumors, including endometrial cancer (EC). The current study evaluates the feasibility of manufacturing TILs from EC tumors using Iovance’s proprietary 22-day Gen2 manufacturing process. Key parameters, including TIL yield, viability, immune phenotype, T-cell receptor clonality, and cytotoxic activity, were assessed. Of the 11 EC tumor samples processed at research scale, 10 (91%) successfully generated >1 × 109 viable TIL cells, with a median yield of 1.1 × 1010 cells and a median viability of 82.8%. Of the four EC tumor samples processed at …

Scarna1 Expression Levels Affect Alternative Splicing Of Mrna, Madeleine Brown, Brittnei Earl, Michael Filla, Nataliya Kibiryeva, James E. O'Brien Jr., Douglas C. Bittel

Student Publications

Our previous research identified 12 small Cajal body-specific RNAs (scaRNAs) with reduced expression in the right ventricle in infant patients with tetralogy of Fallot. Likewise, we showed that there were significant changes in mRNA processing in the RV in these patients. ScaRNAs play a crucial role in the biochemical maturation of spliceosomal RNAs (pseudouridylation and 2′-O-methylation). We showed that variations in scaRNA1 levels resulted in changes in alternative splicing in human cells. To investigate further the role that scaRNAs play in mRNA processing, we examine here the impact of knocking down scaRNA1 in quail myoblast cells (Coturnix japonica, a well-established …

A Wachspress-Type Rational Characteristic Method For Solving First-Order Hyperbolic Equations, Mohamed Al-Lawatia

Sultan Qaboos University Journal For Science

This paper introduces a characteristic method for solving linear first-order hyperbolic partial differential equations in two space dimensions. The algorithm employs rational Wachspress-type basis functions applied to a hexagonal discretization of the domain, integrated within the Eulerian-Lagrangian Localized Adjoint Method (ELLAM) framework. The proposed scheme preserves the strengths of characteristic methods and delivers accurate numerical results, even with large time steps. Computational tests conducted on standard benchmark problems illustrate the effectiveness of the method.

Analysis Of Stress-Jump Condition On The Onset Of Thermal Convection In A Composite System Formed By An Anisotropic Porous Layer Underlying A Fluid Layer, Neetu Srivastava, Naveen Dwivedi, Ashok K. Singh, Nirmal C. Sacheti, B. S. Bhadauria

Sultan Qaboos University Journal For Science

This paper investigates the onset of thermal convection in a bounded system comprising a horizontal viscous fluid layer of infinite extent overlying an anisotropic horizontal permeable layer saturated with the same fluid. It is assumed that this system is heated from below and cooled from above in the presence of internal heat generation. It is also assumed that the material parameters, such as viscosity and thermal conductivity differ between the layers, and that the Brinkman model is used to describe the flow in the porous region. An extensive linear stability analysis has been performed with an aim to determine the …

Effect Of Rotation On Plane Wave Propagation In A Magneto-Thermo Elastic Solid, G Rajkumar, K Somaiah, Srinivas Remidi

Sultan Qaboos University Journal For Science

The present article deals with the effect of angular rotation on the propagation of plane harmonic waves in a homogeneous, isotropic magneto-thermo elastic medium. The governing equations of a generalized magneto-thermo elastic solid are formulated and solved with the method of plane harmonic solution. Three types of waves, namely, plane longitudinal, magneto, and magneto-thermal waves, are significantly affected by the angular rotation of the solid. It is very interesting to observe that the classical result is obtained as angular rotation vanishes. For computational purposes, the available lithium niobate (LiNbO3) material was treated as the model of thermo-magneto elastic medium. The …

Ingenious Impulsiveness Of Environmentally Motivated Female Entrepreneurship For Sustainable Development, Saranya Senthilnathan, Chandrasekar Kaliyaperumal

Management Dynamics

Women's roles are crucial to the economic prosperity of any nation, with their participation in entrepreneurship being a key driver of sustainable development. This study focuses on the contributions of women entrepreneurs in India, highlighting their potential to advance economic, social, and environmental sustainability. The purpose is to examine the role of female entrepreneurs in promoting sustainable practices within the economy, society, and ecology. The study employs a descriptive research design to assess how integrating environmental factors into female entrepreneurship impacts the growth and sustainability of the Indian economy. A self-administered questionnaire was used to collect primary data from 355 …

The Reluctant Heroes: How To Teach Younger Generations Every-Day Heroism Through Pedagogical Imagination, Jarema Drozdowicz

Heroism Science

This article explores the notion of pedagogical imagination in the context of its practical use in teaching young learners today. The idea of imagination is being presented through the lens of the existing concepts such as ethnographic, historical, and sociological imagination introduced in the social sciences and humanities by various authors. The educational setting of today’s digitalized reality is being understood here as a sociocultural sphere where different generations clash in their diverse abilities to learn and form specific skills that might help them to cope with difficult real life situations. The process of forming heroic behavior patterns is thus …

Gain Movie Insights Using Generative Artificial Intelligence, Akash Verma, Vineet Kumar, Abhay Kumar Gupta, Vivek Yadav, Szu-An Lu, Meng-Ting Tsai, Ya Hsien Liu, Chu-Feng Lien

Defensive Publications Series

A television (TV) application may present various types of media content of interest to a user. The media content may have different formats such as streaming video and audio. The types of media content may include, but are not limited to, movies, television shows, live sporting events, news items, short form videos, and music. In addition, or in the alternative, a variety of media content providers may deliver various types of media content for viewing by the user. The TV application may deliver a customized viewing experience to a user that spans the diverse types of media content provided by …

Achieving Equity For International Medical Graduates: A Systematic Review, Sangeeta G. Saxena, Elizabeth Tisdell, Elana Farace, Thomas Godfrey, Betsy Aumiller, Esther Dell, Omrana P. Razzak, Bernadette N. Kumar, Kristin K. Sznajder

Public Health

Introduction: Foreign-born and foreign trained International Medical Graduates (FIMGs) face greater challenges in acculturation to their host countries than IMGs who train abroad and return to practice in their home country. As FIMGs are likely to fulfill a shortage of physicians in High Income Countries in the foreseeable future, we conducted a systematic review of literature to identify acculturation interventions that help FIMGs assimilate better in their host country health systems. This improves their productivity and satisfaction, allows health systems to be more accepting of FIMGs, and most importantly, enhances patient outcomes.

Methods: Following the PRISMA statement, we searched PubMed, …

Kids Exploring The World With Chatbots, Maggie Mckay, Mark Connelly

Parent-ish Podcast

Are your kids chatting away with AI? In this episode, we provide parents with the tools they need to understand the implications of children's interactions with chatbots. Find out what signs to look for and how to set healthy boundaries to protect your child from potential pitfalls of digital companionship.

Click here to stream the podcast episode.

Mapping The Literature On Short-Selling In Financial Markets: A Lexicometric Analysis, Nitika Sharma, Sridhar Manohar, Bruce A. Huhmann, Yam B. Limbu

Department of Marketing Faculty Scholarship and Creative Works

This study provides a comprehensive assessment and synthesis of the literature on short-selling. It performs a lexicometric analysis, providing a quantitative review of 1093 peer-reviewed journal articles to identify and illustrate the main themes in short-selling research. Almost half the published literature on short-selling is thematically clustered around portfolio management techniques. Other key themes involve short-selling as it relates to risk management, strategic management, and market irregularities. Descending hierarchical classification examines the overall structure of the textual corpus of the short-selling literature and the relationships between its key terms. Similarity analysis reveals that the short-selling literature is highly concentrated, with …

Gpu Performance In A Linux Enviroment, Nathanael W. Haines

Summer Interdisciplinary Research Symposium

GPUs are used for both recreational purposes and extremely important simulations for things like earthquake prediction in addition to mathematical modeling. In all cases it is critical that the GPUs used are chosen effectively, as these tend to be very expensive components. By benchmarking a variety of GPUs running on GNU/Linux with a roster of different benchmarks, this project provides information of the capabilities of GPUs running with GNU/Linux, which is common in research settings. This is compared to the expected performance levels of each GPU as stated in selected online sources and manufacturer claims, which are typically geared towards …

The Parthenon, July 23, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Soleil Woolard

The Parthenon

No abstract provided.

Math Information Retrieval From Images Via Formula Extraction, Vector Embedding, And Multimodal Llm-Based Question Answering, Angel Wheelwright Crawford

Theses and Dissertations

Math Information Retrieval (MIR) aims to revolutionize the retrieval of math information by addressing the challenges in representing, retrieving, and producing highly specialized math content. In order to develop a robust MIR system, designers must be able to process math equations (MEs) to a format that different systems can use, which is difficult due to various formats math information are stored in, including visual images and document texts. To improve the usage of math information in varied forms for people who are learning and utilizing math, we propose three different methods of handling ME data. The first method is a …

Biography Of Dr. Susan D. Rutherford, Susan D. Rutherford

Series 01: History of DEAF Media, Inc.

No abstract provided.

About Deaf Media: A History, Susan D. Rutherford, Rick Clogher

Series 01: History of DEAF Media, Inc.

A comprehensive history of DEAF Media, Inc. including its founding, main activities, and purpose for existing.

Temporal And Generational Changes In Depression Among Young American Adults, Ashley W. Kranjac, Dinko Kranjac, Valentine Chung

Sociology Faculty Articles and Research

The prevalence of depression among young American adults has risen significantly over the past two decades, but the mechanisms that underlie the population-level changes in depressive symptoms severity remain unclear. We used data from the 2005–2023 National Health and Nutrition Examination Survey (NHANES) and hierarchical age–period–cohort (HAPC) analysis to examine developmental (i.e., age), life stage (i.e., period), and generational (i.e., cohort) distribution of depressive symptoms among American adults aged 20–30 years old over an 18-year period. Our model results indicate that the probability of either mild, moderate, or severe depression increased among young adult females and males between 2005 and …

An Ai-Driven Framework For Real-Time Fake News Detection: Developing A Machine Learning-Based Filter For News Platforms In The United States, Umma Twaha, Yeasin Arfin

Engineering and Technology

The proliferation of fake news across digital platforms poses a significant threat to democratic processes, public health, and social cohesion in the United States. Manual fact-checking and traditional moderation approaches are increasingly inadequate due to the scale, speed, and sophistication of misinformation campaigns. This presents an AI-driven framework for real-time fake news detection, designed to serve as an intelligent filter for news platforms operating within the US media ecosystem. Leveraging natural language processing (NLP) techniques and machine learning algorithms—including supervised classifiers and deep learning models such as BERT and LSTM—the framework identifies deceptive content with high precision and low latency. …

Utilizing The Combinatory Power Of Chemotherapeutic Compounds In Triple Negative Breast Cancer Cells, Matthew I. Hyder

Biology Summer Fellows

Breast cancer is the leading cause of cancer-related deaths among women worldwide and the second most common cause of cancer deaths in women in the United States. Genetic variants that increase the risk of breast cancer include mutations in the breast cancer susceptibility genes 1 and 2 (BRCA1 and BRCA2). Apoptosis, or programmed cell death, is a natural process that helps the body remove aged cells. However, in cancer, deregulated apoptotic signaling—especially the activation of anti-apoptotic mechanisms—enables cancer cells to evade this process, leading to uncontrolled proliferation, tumor survival, therapeutic resistance, and cancer recurrence. Most anti-cancer drugs function as chemotherapeutic …

The Influence Of Myocardin Effector Genes On The Tgf-Beta Smad3 Signaling Pathway In Human Pleural Mesothelial Cells, Hema Chandra Hrushi Dusharla

Biotechnology Theses

Pleural Fibrosis (PF) involves excessive extracellular matrix (ECM) deposition, mainly by myofibroblasts, leading to pleural thickening and impaired lung function. Pleural mesothelial cells (PMCs) contribute via mesothelial and mesenchymal transition (MesoMT), triggered by cytokines like TGF-β. Our lab identified Myocardin (MyoCD), a transcriptional co-activator of cardiac and smooth muscle, is a master regulator of pleural fibrosis through interactions with serum response factor (SRF) and Smad2/3 transcription factors which initiate fibrosis signaling. RNA sequencing and qPCR analysis revealed that silencing MyoCD decreased the expression of CTNNB1, MDFI, and Tspan2. MDFI emerged as a potent candidate, as this gene affecting the expression …

The Influence Of Sociodemographic Factors On Opioid Mortalities In The U.S. State Of Georgia, Theresa Highsmith

Walden Dissertations and Doctoral Studies

Since the late 1990s, the United States has been in the midst of an opioid epidemic that continues to present significant public health challenges. Opioid-related mortality, particularly involving fentanyl, has disproportionately affected vulnerable populations. The purpose of this quantitative study was to examine the associations between educational level, homelessness, and alcohol use with opioid-related overdose deaths involving fentanyl, while controlling for age, gender, and marital status, among Black and White populations in the U.S. state of Georgia. The theoretical framework was Bronfenbrenner’s socioecological model, which recognizes that individual behavior is influenced by multiple levels of factors, including interpersonal, community, and …

Adolescents' Use Of Music For Pain Management., Rebecca J. Lepping, Lora L. Black, Kymberly A. Kline, Deanna Hanson-Abromeit, Andrea L. Chadwick, Dustin Wallace, William R. Black

Manuscripts, Articles, Book Chapters and Other Papers

To investigate the experiences of adolescents with chronic pain who participated in an intensive interdisciplinary pain treatment program, this secondary study analyzes the themes that emerged regarding the spontaneous utilization of music in coping strategies for chronic pain. During research interviews focused on coping skills and treatment engagement, participants spontaneously reported using music as an effective coping strategy for managing pain. A deductive thematic analysis revealed key themes related to their usage, including using music as a distractor, motivator and in other ways as coping strategies. Since participants indicated that music is essential to their experiences of coping with pain, …

Augustine’S Ethics And Authentic Happiness, Ignatius C. Williams

Say Something Theological: The Student Journal of Theological Studies

Finding happiness is a fundamental human goal, despite the fact that it varies between cultures, philosophical systems, and religious beliefs. But how mankind pursues happiness as the greatest good and how it is reached in that process are considered because not all endeavors ultimately lead to true or authentic happiness. In light of this, Augustine’s notion of ethics and authentic happiness are examined, along with some essential principles for living an ethical life that is congruent with true happiness. Three topics are explored. First, I examined Augustine’s theory of happiness as well as moral requirements centered on grace, love, and …

Effects Of Oxygen Manipulation On Myofibroblast Phenotypic Transformation In Patients With Radiation-Induced Fibrosis, Eric Mastrolonardo, Sarah Sussman, Bo Yun, Victor Jegede, Dev Amin, Joel Rosenbloom, Andrew P. South, Voichita Bar-Ad, Peter J Wermuth, Adam J. Luginbuhl

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

We tested if hyperoxic conditions can reduce the proportion of active myofibroblasts, which are assumed to be a major driver of head and neck radiation-induced fibrosis, as measured by expression levels of pro-fibrotic genes. Radiated, non-cancerous soft tissue from the head and neck and skin/soft tissue from non-radiated flap donor site were collected from each patient. Myofibroblast density was quantified using immunofluorescence staining with α-SMA and DAPI and visualisation under confocal microscopy and compared between baseline non-radiated and radiated tissue from the same patient. From each tissue specimen, fibroblast cell lines were cultured and exposed to either normoxic, hypoxic, or …

Public Support For Puma Reintroduction In The Eastern United States, L. Mark Elbroch, Jazmin J. Murphy, Shelby C. Carlson, John A. Vucetich, Richard E.W. Berl, Lexi Galiardi, Shelby Perry, Tom Butler, Neil Carter, Joseph W. Hinton, Axel Moehrenschlager, Emily Carrollo, Rana Bayrakcismith, Jeremy T. Bruskotter

Michigan Tech Publications

Pumas (Puma concolor) are among the species identified as having the potential to enhance ecosystem function. Previous research highlights sufficient ecological habitat to support pumas in the eastern United States; however, their reintroduction requires social and institutional support as well. To this end, we conducted research to assess attitudes about puma reintroduction among key constituencies like hunters, rural residents, and young people. We sampled 2756 respondents across seven states (Massachusetts, Maine, New Hampshire, New York, Pennsylvania, Vermont, and West Virginia). Ratios of strong support (for puma reintroduction) to strong opposition across states ranged from 4:1 to 13:1, and support outweighed …

Ai Regulation: Competition, Arbitrage & Regulatory Capture, Filippo Lancieri, Laura Edelson, Stefan Bechtold

Georgetown Law Faculty Publications and Other Works

The commercial launch of ChatGPT in November 2022 and the fast development of large language models have catapulted the regulation of artificial intelligence to the forefront of policy debates. A vast body of scholarship, white papers, and other policy analyses followed, outlining ideal regulatory regimes for AI. The European Union and other jurisdictions have moved forward by regulating AI and LLMs. One overlooked area is the political economy of these regulatory initiatives—or how countries and companies can behave strategically and use different regulatory levers to protect their interests in the international competition on how to regulate AI.

This Article helps …

Illness Severity And Marital Communication In Young Couples: The Moderating Role Of Marital Satisfaction, Jaime Lea Dick

Theses and Dissertations

The emergence of a chronic physical illness is unexpected in emerging adulthood and is accompanied by stress. Additionally, married partners of individuals with physical illnesses are likewise affected by the new diagnosis. Marriage outcomes of couples facing chronic illnesses together vary, being sometimes positive and sometimes negative. The current study examined the relationship between the emergence of chronic physical illness in emerging adults and marital communication of both the patient and partner, with marital satisfaction as a moderator. Gender differences are also addressed. From the Couple Relationships and Transition Experiences (CREATE) study, a nationally representative dataset of newly married emerging …

Lindenwood Digest, July 23, 2025, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

Insights From The Front Line: Uplifting Stories Of The Covid-19 Pandemic Through The Eyes Of The Public Health Workforce In Iowa, Heidi Haines, Amanda Sursely, Hanh Pham, Rylee Beltran, Daniel K. Sewell, Lina Tucker Reinders, Natoshia Askelson, Sarah Dixon, Kaitlin Emrich, Christine Estle, Michelle Lewis, Jimmy Reyes

Faculty Publications

Introduction: SARS-CoV-2 was declared a pandemic in March 2020. Studies have characterized some of the negative impact of the pandemic on public health workers (PHW), but few have explored the strength and coping strategies used. Our study documents the experiences of PHW in Iowa during the pandemic. Methods: We used an innovative mixed methods data collection tool, SenseMaker^® to gather stories from PHW in Iowa between March and July 2022. Participants provided additional data about their story via structured follow-up questions. We conducted descriptive analyses of the quantitative questions. A qualitative thematic and sentiment analysis was applied to all …

Infectious Scleritis: A Comprehensive Narrative Review Of Epidemiology, Clinical Characteristics, And Management Strategies, Hamidreza Ghanbari, Masoud Rahimi, Ali Momeni, Kiana Hassanpour, Nikoo Bayan, Karen E. Lee, Alex Hansen, Ali R. Djalilian, Christopher J. Rapuano, Mohammad Soleimani

Wills Eye Hospital Papers

This study aims to provide an update on infectious scleritis (IS). A comprehensive search was conducted using Google Scholar, Scopus, and PubMed. IS is a rare but critical condition that presents significant diagnostic challenges and often leads to poor visual outcomes. It accounts for approximately 5%-10% of scleritis cases and warrants significant attention due to its delayed diagnosis. Ocular surgery is the primary contributor to IS, accounting for a substantial proportion of cases ranging from 58% to 83%, followed by trauma contributing to approximately 10% of cases. IS can be caused by various microorganisms, including bacteria (86%-87%), fungi (11%-13%), viruses, …