Digital Commons Network^™

Complexity And Health Care Utilization In Infant Eskd, Ashna R Pudupakkam, Michael C Braun, Catherine Joseph, Poyyapakkam R Srivaths, Sarah J Swartz, Shweta S Shah

Faculty, Staff and Students Publications

Key Points:

1. Infant ESKD is associated with significant health care utilization including hospitalizations, subspecialty care, and financial expenditures.

2. Further investigation of health care utilization in infant ESKD can help guide the appropriate allocation of resources to support care delivery.

Background: Dialysis in neonates with ESKD is often associated with multiple comorbidities and the need for more intensified dialysis regimens. With recent advances in prenatal interventions and infant-specific KRT, survival of neonates with ESKD has improved over the past decade. Little is known, however, about the impact on the health care system of improved survival in this population. Our primary aim …

Exploring Impacts Of Diversity Ideologies On Allyship (Intergroup Responsiveness), Fiona Nguyen

Dissertations and Theses

Colorblindness and multiculturalism are widely studied diversity ideologies that reflect prominent attitudes about how diversity should be understood and managed, as they can help predict individual behavior. Colorblindness proposes that distinct group identities should be ignored, and can be used to exclude minoritized groups and downplay racial minorities' experiences, whereas multiculturalism embraces and values group differences, can foster inclusive environments for minority groups, and leads to positive intergroup outcomes such as reduced prejudice. Despite much research dedicated to exploring the intergroup outcomes of diversity ideologies, few studies have examined their impacts on specific interpersonal interactions, particularly allyship. Research has defined …

Pathos, Fall 2025, Portland State University. Student Publications Board

Pathos

Editor: Adriana Stanzione

Protein Kinase Rock1 Activates Mitochondrial Fission Linking To Oxidative Stress And Muscle Atrophy, Meijun Si, Jihong Chen, Rizhen Yu, Hongchun Lin, Feng Li, Sungyun Jung, Sandhya S Thomas, Farhard R Danesh, Yanlin Wang, Hui Peng, Zhaoyong Hu

Faculty, Staff and Students Publications

Introduction: Chronic kidney disease (CKD) is associated with protein-energy wasting, characterized by a reduction in muscle mass and strength. Although mitochondrial dysfunction and oxidative stress are implicated in the pathogenesis of muscle wasting, underlying mechanisms remain unclear.

Methods: Here, we used transcriptomic analysis, metabolomics analyses, and mouse gene manipulation to investigate the effects of mitochondrial plasticity and oxidative stress on muscle wasting the subtotal nephrectomy mouse models of CKD. The mice with CKD were age- and sex-matched to sham-operated controls.

Results: Through these approaches, Rho-associated kinase ROCK1 emerged as a key molecule responsible for the observed mitochondrial fission and oxidative …

Transdiagnostic Correlates Of Family Accommodation In Anxious Youth, Whitney S Shepherd, Erika S Trent, Orri Smarason, Hannah N Sansone, Daphne M Ayton, Amanda Palo, Abigail E Candelari, Wayne K Goodman, Andrew G Guzick, Eric A Storch

Faculty, Staff and Students Publications

Anxiety disorders are common in children and cause significant impairment. Family accommodation, which refers to behavioral changes that family members make to temporarily alleviate a child’s anxiety, has been linked to child anxiety symptom severity. Although emotional vulnerabilities for anxiety such as emotion dysregulation, anxiety sensitivity, and distress intolerance have been associated with family accommodation, research concerning the relationship between these constructs among anxious youth is limited. We hypothesized that these variables would be uniquely and positively associated with family accommodation and would moderate the relationship between anxiety symptom severity and family accommodation. Treatment-seeking child–parent dyads (N = 90; …

Alternative Polyadenylation Contributes To Fibroblast Senescence In Pulmonary Fibrosis, Jingjing Huang, Maria Jose Gacha-Garay, Yu Wang, Scott D Collum, Rene A Girard, Hydia Puente, Seung-Hee Yoo, Rahat Hussain, Jayeshkumar Patel, Manish Patel, Eric J Wagner, Hari Krishnayalamanchili, Harry Karmouty-Quintana, Zheng Chen, Tingting Mills

Faculty, Staff and Students Publications

Idiopathic pulmonary fibrosis (IPF) is a prevalent and deadly age-related disease characterized by chronic, progressive, and irreversible fibrosis. A key effector cell population in the fibroproliferative response is the fibroblasts. Fibroblast cell senescence gradually worsens during aging, and the acquisition of a senescence-associated secretory phenotype (SASP) turns senescent fibroblasts into pro-inflammatory cells. However, the mechanism promoting senescence in IPF, especially at the post-transcriptional level, is poorly understood. We recently discovered that Nudix Hydrolase 21 (NUDT21, also named CFIm25), an RNA-binding protein, plays a critical role in regulating the expression of SASP factors through alternative polyadenylation (APA). APA allows adding poly(A) …

La Vida Social Del Programa Abriendo Oportunidades® En Guatemala: Tres Décadas Habilitando Espacios Comunitarios Y Cívicos Para Niñas Y Mujeres Indígenas, Population Council

Adolescents and Young People

Desde 2004, Abriendo Oportunidades^® (AO^®) surgió como un programa social transformador de género dirigido a niñas y mujeres jóvenes indígenas en el contexto de posguerra en Guatemala. Siguiendo un enfoque basado en evidencia y anclado en las comunidades, AO^® comenzó como un programa y ha evolucionado hasta convertirse en un movimiento social. AO^® ha demostrado continuamente su impacto en la reducción de la exposición de las niñas a la violencia de género y fue pionero en la educación alternativa mediante un modelo de mentoras como tutoras. Con el tiempo, AO^® ha alcanzado a más …

Changing Lives, Transforming Communities: How Young Feminist Organizations Create Change In Mexico And Kenya, Population Council Kenya

Adolescents and Young People

The Young Feminist Organizing (YFO) study was initiated in response to a call for proposals by two anonymous funders to conduct a Participatory Action Research evaluation (PARe) of young feminist movements across Kenya and Mexico. The project was implemented by the Population Council in Kenya and Mexico, with technical support from the GIRL Center, and through a Feminist Advisory Panel (FAP) and a Core Participatory Evaluation Community (Core PARe). The study's duration was 31 months, starting from September 2022 to March 2025. This end-of-project report summarizes the key findings, lessons learned, challenges encountered, mitigation strategies employed, and emerging opportunities.

Improving The Accessibility Of Speech For Deaf And Hard-Of-Hearing Individuals Through Affective Captions, Caluã De Lacerda Pataca

Theses

Captions have traditionally served as a bridge between the spoken word and its written representation, helping make speech accessible to Deaf and Hard-of-Hearing (DHH) individuals. It is worth considering, however, how much from speech is left out by this ’bridging’ between sound and visuals. This dissertation describes a research project that has, over six studies, looked at this very issue. We first examined whether there is an issue here at all. What does the experience of DHH individuals with captioning systems tell us about these systems’ shortcomings? For one, we found, captions are felt as monotonous and ambiguous. While communication …

Understanding Impact Among Young Feminist Organizing/Organizations In Kenya, Chantalle Okondo, John Malkia, Ivy Kutswa, Ruth Juliet, Sar Kagendo, Stacie Akinyi, Terry Owino, Jerry Okal

Adolescents and Young People

The Nawiri Project used a core Participatory Action Research Evaluation (PARe) approach to explore the landscape of young feminist organizing/organizations (YFOs) in Kenya and Mexico. The project aimed to synthesize evidence on YFOs’ context, impact, and strengths. In Kenya, the core PARe team included nine young feminists and seven Feminist Advisory Panel (FAP) members, who collaborated with Population Council–Kenya from the project’s inception to dissemination. To define and measure impact, the team conducted five case studies with YFO leadership, nine focus group discussions with YFO beneficiaries, 31 key informant interviews with current and previous partners, and cost and benefit analysis …

Tigit Affects Car Nk-Cell Effector Function In The Solid Tumor Microenvironment By Modulating Immune Synapse Strength, Ishwar Navin, Matthew Dysthe, Prashant S Menon, Corrine Baumgartner, Tim Sauer, Navin Varadarajan, Robin Parihar

Faculty, Staff and Students Publications

Therapies using NK cells that express chimeric antigen receptors (CAR-NK) have been successfully employed against hematologic malignancies. However, solid tumors resist CAR-NKs partly by enriching tumor microenvironments with ligands for NK cell inhibitory receptors. Although the NK inhibitory receptor T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) has been implicated in impaired antitumor activity of endogenous NK cells, the consequences of TIGIT expression on engineered CAR-NKs have not been explored. To address this gap, we compared TIGIT-expressing and TIGIT-deleted human CAR-NKs targeting the GD2 solid tumor antigen in tumor immune microenvironment co-cultures and in vivo tumor immune …

Prevalence Of Risk Factors And Severity Level Of Diabetic Retinopathy In Uitm Medical Specialist Centre:An Ordinal Analysis, Aniza Ayuna Che Jani, Zuraida Khairudin, Nornadiah Mohd Razali, Nor Azimah Abd Aziz, Hezlin Aryani Abd Rahman, Nur Syamimi Haji Abu Bakar

Malaysian Journal of Computing (MJoC)

Diabetic Retinopathy (DR) has become a major concern as the number of diabetic patients who are diagnosed with DR has been on the rise each year. Hence, the adoption of a strategic approach is needed to determine the factors that contribute to the level of severity in DR patients. This research aims to determine the significant risk factors influencing the severity level of DR as well as to evaluate the classification rate between the severity level of 157 patients at UiTM Private Specialist Centre by employing the Ordinal Logistic Regression (OLR) analysis. The study revealed that there were 60 (38%) …

Editor's Introduction, Michael D. Pante

Philippine Studies: Historical and Ethnographic Viewpoints

No abstract provided.

Mitochondrial Dysfunction And Lipid Dysregulation In Yeast Lacking Phosphatidylserine, Alaumy Joshi, Zakery N Baker, Rachel A Stanfield, Dimitris T Kalafatis, David J Pagliarini, Vishal M Gohil

2020-Current year OA Pubs

Mitochondrial membrane phospholipids impact mitochondrial structure and function by influencing the assembly and activity of membrane proteins. Although the specific roles of the three most abundant mitochondrial phospholipids, phosphatidylcholine (PC), phosphatidylethanolamine (PE), and cardiolipin (CL), have been extensively studied, the precise function of less abundant phosphatidylserine (PS) is not yet determined. Here, we used genetic and nutritional manipulation to engineer a set of yeast mutants, including a mutant completely devoid of PS, to assess its role in mitochondrial bioenergetics and lipid homeostasis. To circumvent the confounding effect of downstream PS products, PE and PC, we exogenously supplied ethanolamine that allows …

Exposure To Household Air Pollution From Biomass Cooking And Severe Pneumonia In Infants, John P Mccracken, Lindsay J Underhill, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Household air pollution from biomass cooking is considered an important risk factor for child pneumonia.

OBJECTIVE: To evaluate the longitudinal association between exposure to particulate matter with a diameter of less than or equal to 2.5 µm (PM2.5) or carbon monoxide (CO) and severe pneumonia in infants.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study included infants (aged ≤12 months) whose mothers participated in a 4-country randomized clinical trial. Conducted from May 2018 to September 2021, the trial tested whether an 18-month liquefied petroleum gas stove and fuel distribution intervention reduced the incidence of severe pneumonia in offspring during infancy …

Identification Of Surrogate Outcome Biomarkers In Lung Allograft Recipients With Bronchiolitis Obliterans: Implications For Randomized Controlled Trials, Derek E. Byers, Suresh Vedantham, Mary Clare Derfler, Paul Commean, Andrew Atkinson, Jeff Atkinson, Alexey Prokudin, John Mccarthy, George Despotis, Et Al.

2020-Current year OA Pubs

BACKGROUND: We developed a prospective, multicenter "registry" to evaluate the effect of extracorporeal photopheresis for lung transplant recipients who develop chronic lung allograft dysfunction (CLAD) with the bronchiolitis obliterans syndrome (BOS) phenotype (CLAD/BOS) and who are refractory to conventional standard-of-care therapy.

METHODS: Data from 258 lung transplant recipients enrolled in the Registry between April 2015 and April 2022 were included in this analysis. All recorded parameters (eg, demographics), including forced expiratory volume in 1 s (FEV

RESULTS: Mortality at 6 and 12 mo after CLAD/BOS diagnosis was 5% and 14%, whereas mortality at 6 and 12 mo after enrollment was …

Complementary, But Not Equivalent: Clarifying The Role Of Rwe And Rct In Migraine Research, Mario F. P. Peres, Hsiangkuo Yuan, Cristina Tassorelli

Department of Neurology Faculty Papers

No abstract provided.

Leveraging De-Implementation Science To Promote Infection Prevention And Stewardship: A Roadmap And Practical Examples (Part Ii Of Ii), Westyn Branch-Elliman, Jennie H Kwon, Et Al.

2020-Current year OA Pubs

De-implementation of established practices is a common challenge in infection prevention and antimicrobial stewardship and a necessary part of the life cycle of healthcare quality improvement programs. Promoting de-implementation of ineffective antimicrobial use and increasingly of low-value diagnostic testing are cornerstones of stewardship practice. Principles of de-implementation science and the interplay of implementation and de-implementation are discussed in part I of this Society for Healthcare Epidemiology of America White Paper Series.In this second part of the series, we discuss a process for applying principles of de-implementation science in infection prevention and stewardship and then review some real-world examples and case …

47th Biennial Convention Of Sigma Gamma Epsilon, Western Illinois University, April 11–13, 2025, Richard L. Ford, Lee S. Potter

The Compass: Earth Science Journal of Sigma Gamma Epsilon

The Society of Sigma Gamma Epsilon (SGE), the national honorary society for the Earth sciences, held its 47th biennial convention (April 11–13, 2025) at the Quad Cities campus, located in Moline, Illinois, of Western Illinois University (WIU). The convention was hosted by SGE’s Delta Psi Chapter and the Department of Earth, Atmospheric, and Geographic Information Sciences at WIU. Ten (10) of SGE’s approximately 57 active collegiate chapters sent delegates to the convention. The traditional convention field trip, an exploration of the Paleozoic stratigraphy and economic geology of the Quad Cities area of Illinois and Iowa, made stops at the Fryxell …

The Compass - Volume 94 Issue 3 - Complete Issue, Scott R. Beason

The Compass: Earth Science Journal of Sigma Gamma Epsilon

No abstract provided.

Assessing Population Dynamics And Stock Status Of Pomadasys Kaakan In The Northern Sea Of Oman, Sultanate Of Oman, Fatma Al Harbi, Khulood Al Bulushi, Sachinandan Dutta

Journal of Agricultural and Marine Sciences

This study aimed to assess the life history and population status of Pomadasys kaakan, Cuvier, 1830, known as ‘Nagroor’, in the Sea of Oman to determine an optimal sustainable yield and provide management recommendations for maintaining stock sustainability. Biological data, including length, weight, age, gonad weight, and maturity stages, were collected monthly in 2016 from the Dibba fish landing center in the Musandam region of the Sultanate of Oman. The Beverton-Holt model was used to determine fish stock status. The length-weight relationship for P. kaakan was described by W = 0.03L2.81, indicating negative allometric growth (t = 0.0318, P > 0.05). …

Consumption Of Plant-Based Meat As An Alternative To Animal Meat: Empirical Evidence On Behavioral Intentions, Deena Al Kalbani, Mohammed Al Rizeiqi, M. R. Razzak, Ismail Al-Bulushi, Adil S. Al-Busaidi, I. Khan, P. Pathare

Journal of Agricultural and Marine Sciences

Empirical evidence indicates that rising consumption of animal meat negatively could contribute to climate change and public health. As a result, meat alternatives such as plant-based meat (PBM) have emerged as a potential solution. However, there seems to be a dearth of insights regarding significant drivers of people’s behavioral intentions (BI) towards PBM. This study leverages the theory of planned behavior to determine whether attitude, social norms, and perceived behavioral control influence BI towards PBM. Survey data was collected from 380 respondents in Oman to test the relationships between the constructs in the research framework. The results indicated that attitude …

Recovery Of Magnesium Sulfate And Calcium Sulfate From Zinc Flotation Tailing, Raquel Húngaro Costa, Jonathan Tenório Vinhal, Tatiana Scarazzato, Denise Crocce Romano Espinosa

Journal of Sustainable Mining

Resource recovery is a process that has been used to obtain products from industrial waste. Mining tailings can be used as an alternative through ore beneficiation to create by-products for this type of waste. The work herein investigated the recovery of two products from a real tailing generated in the Zn beneficiation route in the flotation step. A non-magnetic fraction was submitted to a hydrometallurgical route to produce MgSO₄ and CaSO_4. Thermodynamic simulations using FactSage software were performed to evaluate the optimal leaching conditions varying the S:L ratio, the sulfuric acid concentration, and temperature. The best modeled conditions …

Appropriate Blackness: Feminism, C.R.T, Marxism & Boxing, Olene Togiailua

Journal of the Symposium of University Research and Creative Expression

Project Mentor(s): Cynthia Pengilly, PhD

Black people of the Progressive era were concerned with how to regulate their behavior to better their position in society. This research will examine the synthesis of gender performativity, critical race theory, Marxism, and psychoanalysis to create an assimilation identity strategy called “Appropriate Blackness” and how it is demonstrated through the sport of Boxing. The case study subject of all these different frameworks is the first Black Heavyweight champion of the world, Jack Johnson, who was the premier Black celebrity during the Progressive Era and thus an example for a specific gender strategy many working-class …

Antibiotic Resistance Trends In Coliform Bacteria Of Kittitas County Waters, Kaitlyn Holbrook, Bella Blasingim, Cruz Veronica Guillen Mejia, Holly Pinkart

Journal of the Symposium of University Research and Creative Expression

Project Mentor(s): Holly Pinkart, PhD

Since the mid-1900s, antibiotics have been developed to help fight against bacterial pathogens. However, bacteria can evolve rapidly and have evolved resistance to many types of antibiotics. Using coliform bacteria collected from waters around Kittitas County, BIOL 323 students at Central Washington University have identified a variety of antibiotic-resistant bacteria in Kittitas County streams and canals. Antibiotic resistance was measured from 2014-2019 and compared to data collected in 2024. This study focuses on three antibiotics, ampicillin, kanamycin, and trimethoprim-sulfamethoxazole. In the past (2014-2019) we saw no change in the trend of antibiotic resistance in collected …

Characteristics Contributing To The Risk Of Diabulimia In Adults Living In The United States, Danielle Van Hout, Nicole Stendell-Hollis, Tafere Gebreegziabher Belay, Kelly Pritchett

Journal of the Symposium of University Research and Creative Expression

Project Mentor(s): Nicole Stendell-Hollis, PhD, RDN; Tafere G Belay, PhD; Kelly Pritchett, PhD, RDN, CSSD

The purpose of this study was to determine the prevalence and factors that contribute to the risk of diabulimia by using the validated Diabetes Eating Problem Survey-Revised (DEPS-R)¹ screening tool in adults living in the U.S., as well as to examine differences in individuals at-risk and not-at-risk for diabulimia. This observational study included a 30-question Qualtrics survey containing the DEPS-R distributed via various social media outlets and flyers on the CWU Ellensburg campus. Participants were required to be 18 years or older, diagnosed with …

Literary Networks Everywhere: An Analysis Of Literary Connections Across Time And Culture, Rachel Riffel

Journal of the Symposium of University Research and Creative Expression

Project Mentor(s): Katharine Whitcomb

This paper explores the concept of literary discourse as a networked form, using Caroline Levine’s theory of “networks” as expansive systems of meaning. Through the poetry of several postmodern poets and their texts such as Terrance Hayes’ American Sonnets for My Past and Future Assassin, Anne Carson’s The Beauty of the Husband, and Maggie Nelson’s Bluets, this essay analyzes how contemporary poets use intertextuality, historical references, and classical forms not as rigid structures but as connective nodes in a broader literary web. These texts illustrate how poetry continues to participate in an evolving cultural and literary …

Frida Kahlo: More Than The Unibrow, A Cultural Feminist Analysis, Karen Valencia

Journal of the Symposium of University Research and Creative Expression

Project Mentor(s): Erika Pazian

Frida Kahlo has been a common name in the art historical canon – one that reinvented Surrealism, despite not identifying with the style, and challenged conventional norms in artistic practices. Many of her works are discussed in Mexican art historical settings, however, the research of this paper will point the bulk of its focus directly onto The Two Fridas, offering additional discussion on how it connects to feminist theory. Kahlo was a deeply complicated woman, reduced to her bus incident, or tumultuous relationship with muralist Diego Rivera. The materials used as sources in this paper will …

Turkish Eyes For America: How Turkey Embraced The United States In The Interwar Period, Jack Goodwin

The Ozark Historical Review

This research discusses the unique relationship developed between the United States and Turkey between world wars and invites us to reconsider the popular understanding of the United States’ place in Turkey and questions the ways American officials believed were the most effective at spreading their national ideals and culture.

Table Of Contents, Chronos

Chronos

No abstract provided.