Digital Commons Network^™

Anoikis Resistance And Metastasis Of Ovarian Cancer Can Be Overcome By Cdk8/19 Mediator Kinase Inhibition, Mehri Monavarian, Resha Rajkarnikar, Emily Faith Page, Asha Kumari, Liz Quintero Macias, Felipe Massicano, Nam. Y. Lee, Sarthak Sahoo, Nadine Hempel, Mohit Kumar Jolly, Lara Ianov, Elizabeth Worthey, Abhyudai Singh, Igor Roninson Ph.D., Eugenia Broude Ph.D., Mengqian Chen Ph.D., Karthikeyan Mythreye

Faculty Publications

Anoikis resistance, or evasion of cell death triggered by matrix detachment, is a hallmark of cancer cell survival and metastasis. We showed that repeated exposure to suspension stress followed by recovery under attached conditions leads to development of anoikis resistance. The acquisition of anoikis resistance was associated with enhanced invasion, chemoresistance, and immune evasion in vitro and distant metastasis in vivo. This acquired anoikis resistance was not genetic, persisting for a finite duration without detachment stress, but was sensitive to CDK8/19 mediator kinase inhibition that could also reverse anoikis resistance. Transcriptomic analysis revealed that CDK8/19 kinase inhibition induces bidirectional transcriptional …

2026 January 15 - From My Notepads Newsletter, Office Of The President, East Tennessee State University, Brian Noland

From My Notepads: A Newsletter from President Brian Noland

No abstract provided.

“It Seems Like A Never-Ending Job”: Voices Of Female Caregivers Of Older Adults In The Rural Communities, Lalani Nasreen, Bhagyashree Katare, Evans Appiah Osei, Siqi Yang, Sampada Wagle, Julian L. Gallegos, Abidemi Mary Ajuwon

School of Nursing Faculty Publications

Background: Rural female caregivers of older adults face significant caregiving challenges that puts them at high risk for poor self-care and wellbeing. Limited studies have examined the self-care needs of caregivers from a gender equity and social perspective.

Objective: Our study aims to explore the self-care needs and preferences of rural female caregivers and underlying key processes contributing toward their health and well-being. Methods: A qualitative descriptive design was used for the study. A purposive sample of (n = 20) rural female caregivers was obtained. In-depth individual interviews were conducted for data collection. Each interview was about 45- 60 min …

Socioecological Stressors During Covid-19 Among Urban Refugee Youth In Kampala, Uganda: A Qualitative Descriptive Analysis, Sikky Shiqi Chen, Carmen H. Logie, Frannie Mackenzie, Moses Okumu, Robert Hakiza, Brenda Katisi, Daniel Kibuuka Musoke, Aidah Nakitende, Isha Berry, Bay Bahri, Peter Kyambadde

Journal of Social, Behavioral, and Health Sciences

Limited studies have examined pandemic-related stressors among urban refugee youth in low and middle-income humanitarian countries (LMICs), such as Uganda. We explored the lived experience of COVID-19-related stressors among urban refugee youth in Kampala, Uganda. We analyzed qualitative data (text messages, WhatsApp chats, photos) collected in an interactive mobile health intervention with 346 refugee youth aged 16–24 in Kampala. Findings revealed stressors across socioecological levels: individual (e.g., financial-related distress), social (e.g., limited social interactions), community (e.g., food insecurity), and policy (e.g., unprecedented lockdowns). Findings can inform social work organization pandemic preparedness strategies for economic empowerment and social cohesion with youth.

Rab5c Increases Endothelial Release Of Vwf By Regulating Vesicle Trafficking, Paula Reventun, Pablo Toledano-Sanz, Maria Delgado-Marin, Maria Viskadourou, D Brian Foster, Paul S De Vries, Maria Sabater-Lleal, Nunzio Alcharani, Claudia Gonzalez-Cucharero, William O Osburn, Alanna C Morrison, Alisa S Wolberg, Nicholas L Smith, Marios Arvanitis, Charles J Lowenstein

Faculty, Staff and Student Publications

Background: Abnormal levels of VWF (von Willebrand Factor) are a risk factor for venous thromboembolism (VTE) and bleeding. Genome-wide association studies for VWF have identified novel candidate genes that may regulate VWF levels in humans, including RAB5C (RAS-associated protein RAB5C). We hypothesized that RAB5C regulates VWF release from endothelial cells.

Methods: We studied the effect of RAB5C on vesicle trafficking in human endothelial cells. We performed CRISPR (clustered regularly interspaced short palindromic repeats) interference targeting 2 genetic variants linked to altered VWF levels and evaluated RAB5C expression by reverse transcription-quantitative polymerase chain reaction. We silenced RAB5C or overexpressed RAB5C wild-type, …

Kenyon Collegian - January 15, 2026

The Kenyon Collegian

No abstract provided.

Infants And Young Children Feeding Practices Among Mothers Attending Primary Health Care Centers In Basrah, Jhood Molan, Russell Abdul Hussain, Naba Jawad Kazem, Alaa Kazem Lefta, Heba Abdul Razzaq Hassan

Iraqi National Journal of Medicine

Background: Malnutrition accounts for sixty percent of annual deaths among children under five years in developing countries, attributed to inappropriate feeding practices, including non-diverse and insufficient feeding. Improving the nutrition of children under five is a top priority for human development in these regions. Caregivers’ knowledge, attitudes, and practice of young child feeding are essential factors for child health and growth. Aim: The primary aim of this study was to assess infants and young children feeding practice among mothers attending primary health care centers in Basrah. Methods: A cross-sectional study was conducted involving 250 mothers attending five primary health care …

Does Valsartan Affect The Cytotoxicity Of Doxorubicin When Used As A Cardioprotective Drug Against Doxorubicin-Induced Cardiotoxicity ?, Shaymaa Fadhil Abbas, Ahmed Bader Abdulwahid, Duha Emad Omran, Nehaya Mnahi Al-Aubody, Mohammad Fawzi Albadran

Iraqi National Journal of Medicine

Background: Doxorubicin is widely used as a chemotherapeutic drug. It has several serious side effects, including cardiotoxicity. Valsartan is an angiotensin II receptor blocker that plays a cardioprotective role against doxorubicin-induced cardiotoxicity. Aim: The aim of our study is to evaluate whether the combination of valsartan and doxorubicin affects the therapeutic efficacy of doxorubicin in treating cancer using an in vitro breast cancer cell line (MCF-7). Methods: Different concentrations of doxorubicin, valsartan, and their combination were tested to detect their cytotoxic effects on the cell line using MTT colorimetric assay method. Three duplicates of each concentration and control were made. …

Measles Outbreak In Anbar Province During 2023-2024. Demographic Distribution And Vaccination Status, Rafi Alani, Mohammed Dawood

Iraqi National Journal of Medicine

Background: This is the first public study covering all cities in Anbar Province regarding the measles outbreaks occurred in 2023 and 2024. Aim: To estimate the demographic distribution of measles among infected children (age, gender, residence) in Anbar Province and to study the effectiveness of the measles vaccine for each patient on infection. Methods: A retrospective analytic cross-sectional study was conducted across all sectors of Anbar Province. The patients included those who were admitted, diagnosed, and treated in various hospitals during the measles outbreak in 2023, and 2024 years. The data was recorded in files of the Anbar Public Health …

Within Boundaries: Collecting And Exhibiting Chinese Contemporary Art In M+, Hong Kong, Lei April Liu

Masters Theses

This thesis investigates how M+, Hong Kong’s museum of twentieth- and twenty-first-century visual culture, collects and exhibits Chinese contemporary art under political and institutional constraint. It argues that M+ operates through adaptive autonomy, a condition in which curatorial and educational strategies transform limitation into method. By analyzing the museum’s formation, exhibition practices, and comparison with other Asian institutions such as the Asia Culture Center in South Korea, the Power Station of Art in China, and the National Gallery Singapore, the study reveals how M+ sustains visibility of Chinese contemporary art with political sensitive topic through 绥靖 (Sui Jing; subtle appeasement) …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

The Relevance Of Climate Change And Sustainability In Nursing Education: A Cross-Sectional Study Of Students’ Perspectives, Jennie Aronsson, Marie Elf, Paul Warwick, Riccardo Lomartire, Anna Anåker

Individual Articles

Background: As climate change continues to challenge global health, nursing education must evolve to prepare future nurses for the impacts on care delivery and promote sustainable practices within the healthcare system which is itself a contributor to the climate crisis through emissions and waste. In this study we aimed to i) explore undergraduate nursing students’ attitudes towards and awareness of climate change and sustainability issues and its inclusion in nursing education at a Swedish university, and ii) explore differences in awareness and attitudes across student groups in different semesters.

Methods: In this cross-sectional descriptive research study, nursing students from six …

Mooring Analysis In Offshore Floating Labs: Case Study On A 15 Mw Wind Platform, Chenyu Zhao, Jiaxin Chen, Lars Johanning

School of Engineering, Computing and Mathematics

As floating offshore wind turbines (FOWTs) expand into deeper and more complex marine environments, validating mooring system performance under real-world conditions becomes critical. This study investigates whether the purposely designed offshore floating laboratory (OffLab), named ACTOR, can serve as an effective and conservative testbed for mooring line evaluation. ACTOR is a conceptual platform inspired by the floater of the UMaine VolturnUS-S 15 MW semi-submersible FOWT design. The dimension of the ACTOR is about one third of the 15 MW semi-sub floater and is intended deployment in a nearshore UK site with milder sea conditions. Using site-specific environmental data from two …

Differentiated Learning In Pgsd: Enhancing Innovation In Teaching Module Development To Accommodate Students' Learning Styles, Dian Fitri Nur Aini Dian, Falisyta Roisatul Mar'atin Nuro

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Differentiated learning is an effort to meet learning needs by adjusting to the diverse learning readiness, learning profiles, and interests of each student. Differentiated learning is expected to create effective teaching and learning activities, give students the freedom to exercise their right to learn, and facilitate students' learning needs to develop their abilities. The basic elements of differentiated learning include four (4) aspects, namely: 1) learning environment, 2) curriculum, 3) assessment, 4) learning process. These four elements are interrelated. This research model is qualitative research. The research model used in this study is a descriptive model with the aim of …

A Conversation Between Jackson Katz And Douglas Kellner On Guns, Masculinities, And School Shootings, Jackson Katz, Douglas Kellner

Fast Capitalism

No abstract provided.

The Passing Of Jean Baudrillard, Robert J. Antonio

Fast Capitalism

No abstract provided.

"Privatized" Militarism: A New Era?, Carl Boggs

Fast Capitalism

No abstract provided.

The Disintegration Of Fordism And The Transformation Of Black Anti-Semitism In America, 1945-2005, Mark P. Worrell

Fast Capitalism

No abstract provided.

On Werner Herzog's Documentary Grizzly Man: Psychoanalysis, Nature, And Meaning, John W. White

Fast Capitalism

No abstract provided.

Evil Bert Laden: Viral Texts, Community, And Collision, James J. Brown Jr.

Fast Capitalism

No abstract provided.

Massive Multi-Player Online Games And The Developing Political Economy Of Cyberspace, Mike Kent

Fast Capitalism

This article explores economics, production and wealth in massive multi-player online games. It examines how the unique text of each of these virtual worlds is the product of collaboration between the designers of the worlds and the players who participate in them. It then turns its focus to how this collaborative construction creates tension when the ownership of virtual property is contested, as these seemingly contained virtual economies interface with the global economy. While these debates occur at the core of this virtual economy, at the periphery cheap labor from less-developed economies in the analogue world are being employed to …

The War Between N+1 And The Elegant Variation, Or When Production Overlooks Consumption In The Literary Political Economy, Elisabeth Chaves

Fast Capitalism

No abstract provided.

"Say It Loud, I'M Black And I'M Proud": Organizing Since Katrina, Diane Harriford, Becky Thompson

Fast Capitalism

No abstract provided.

Exploring The Liquid Politics Of Tourism: Developing Reflexivity In Backpacker Discourse, Rebecca Jane Bennett

Fast Capitalism

No abstract provided.

Saying Something Or Having Something To Say: Attention Seeking, The Breakdown Of Privacy, And The Promise Of Discourse In The Blogosphere, Gloria E. Jacobs

Fast Capitalism

No abstract provided.

Knowledge And Cultural Production In The Context Of Contemporary Capitalism: A Response To Wittkower, Jeremy Hunsinger

Fast Capitalism

No abstract provided.

Revolutionary Industry And Digital Colonialism, D.E. Wittkower

Fast Capitalism

No abstract provided.

About The Authors, Fast Capitalism Editorial Team

Fast Capitalism

No abstract provided.

Front Matter, Fast Capitalism Editorial Team

Fast Capitalism

No abstract provided.

Full Issue, Fast Capitalism Editorial Team

Fast Capitalism

No abstract provided.