Digital Commons Network^™

Development Of Human Trophoblast Cell Surface Antigen-2 (Trop-2) Specific Radiopharmaceutical Tracers, Arnav Vipulkumar Patel

ETDs from 2020-2029

Trophoblast cell surface antigen 2 (Trop2) is closely related to the development and progression of triple-negative breast cancers (TNBC) and is also being investigated as a pan-cancer biomarker. Trop-2 tumorigenesis is mediated by the calcium ion signaling pathways. By accurately predicting and targeting Trop-2 for immunotherapy, precision therapy is crucial. Trop-2 is overexpressed in tumor tissues compared to normal tissues, which makes it a promising molecular target for cancer-targeted therapy. This thesis reports the development and preclinical evaluation of two novel Trop-2-specific radiopharmaceutical tracers derived from the clinically approved antibody-drug conjugate Sacituzumab Govitecan (SG): a full antibody drug conjugate-based tracer …

Hybrid Quantum-Classical Optimization Of The Resource Scheduling Problem, Tyler Christeson, Md Habib Ullah, Ali Arabnya, Amin Khodaei, Rui Fan

Electrical and Computer Engineering: Faculty Scholarship

Resource scheduling is critical in many industries, especially in power systems where the Unit Commitment (UC) problem determines the on/off status and output levels of generators under physical and economic constraints. Traditional exact methods, such as Branch-and-Bound, Branch-and-Cut, dynamic programming and mixed-integer linear programming (MILP), remain the backbone of UC solution techniques, but they often rely on linear approximations or exhaustive search, leading to high computational burdens as system size grows. Metaheuristic approaches, such as genetic algorithms, particle swarm optimization, and other evolutionary methods, have been explored to mitigate this complexity; however, they typically lack optimality guarantees, exhibit sensitivity to …

Differentiation In The Human Urothelia Is Defined By Distinct Alternative Polyadenylation, Ninh B Le, Surbhi Sona, Briana Santo, Yi Zhang, Rosie Ou, R Allen Schweickart, Veena Kochat, William I Padron, Kunal Rai, Shih-Han Lee, Joo Mi Yi, Oliver Wessely, Byron H Lee, Angela H Ting

Faculty, Staff and Student Publications

Distinct epithelial cell states arise during differentiation, but mechanisms generating transcriptomic diversity among them remain poorly defined. The human ureter urothelium contains basal progenitor, intermediate cells, and terminally differentiated umbrella cells. Prior single-cell RNA sequencing revealed similar global gene expression profiles across these states, raising the question of how distinct identities emerge. Here, we show that alternative cleavage and polyadenylation (APA) introduces a major layer of transcriptomic diversity during urothelial differentiation, largely independent of changes in mRNA levels. Analysis of 13,544 urothelial cells identified hundreds of differentiation-associated APA events. Single-cell imaging revealed spatially specific APA patterns, and reporter assays demonstrated …

Differentiation In The Human Urothelia Is Defined By Distinct Alternative Polyadenylation, Ninh B Le, Surbhi Sona, Briana Santo, Yi Zhang, Rosie Ou, R Allen Schweickart, Veena Kochat, William I Padron, Kunal Rai, Shih-Han Lee, Joo Mi Yi, Oliver Wessely, Byron H Lee, Angela H Ting

Faculty, Staff and Student Publications

Distinct epithelial cell states arise during differentiation, but mechanisms generating transcriptomic diversity among them remain poorly defined. The human ureter urothelium contains basal progenitor, intermediate cells, and terminally differentiated umbrella cells. Prior single-cell RNA sequencing revealed similar global gene expression profiles across these states, raising the question of how distinct identities emerge. Here, we show that alternative cleavage and polyadenylation (APA) introduces a major layer of transcriptomic diversity during urothelial differentiation, largely independent of changes in mRNA levels. Analysis of 13,544 urothelial cells identified hundreds of differentiation-associated APA events. Single-cell imaging revealed spatially specific APA patterns, and reporter assays demonstrated …

Conned By The Enemy: The Entomopathogenic Fungus Metarhizium Anisopliae Lures And Kills Drosophila Suzukii, Ibrahim M. Farid, Shepard Ndlela, Paul G. Becher, Christopher W. Weldon, Abdelmutalab Ga Azrag, Helgi B. Schiöth, Samira A. Mohamed, Sunday Ekesi

All Peer-Reviewed Publications

BACKGROUND: Drosophila suzukii, commonly known as spotted wing drosophila (SWD), is a highly invasive and economically major pest that inflicts significant damage on soft-skinned fruit crops, including raspberries, blueberries, strawberries, blackberries, cherries and grapes. The recent invasion of D. suzukii in Africa represents a key impediment to the berry industry on the continent. Conventional control strategies for this pest rely heavily on chemical insecticides, which pose several adverse side effects on biodiversity and environmental health. In this study, we evaluated five Metarhizium anisopliae isolates (ICIPE 7, ICIPE 18, ICIPE 20, ICIPE 30, ICIPE 78) for development as a biopesticide for …

Payload Diversification Overcomes Resistance And Guides Sequential Antibody-Drug Conjugate Therapy In Breast Cancer, Dileep Reddy Rampa, Minji Seo, Nanae Ogata, Zhaoxuan Yang, Nithya Sridhar, Fujii Takeo, Chalothorn Wannaphut, Jennifer A Maynard, Kyoji Tsuchikama, George W Sledge, Naoto T Ueno, Jangsoon Lee

Faculty, Staff and Student Publications

Purpose: Antibody-drug conjugates (ADCs) have transformed the treatment of breast cancer. FDA-approved ADCs such as trastuzumab deruxtecan (T-DXd), sacituzumab govitecan (SG), and datopotamab deruxtecan (Dato-DXd) have demonstrated clinical benefit; however, drug resistance will almost inevitably emerge in the metastatic setting, and there is no established strategy for selecting subsequent ADCs after disease progression to the first exposure to the ADC. This study aimed to define mechanisms of acquired resistance and evaluate rational sequencing approaches.

Experimental design: We generated breast cancer cell lines resistant to T-DXd (TDXd-R) and SG (SG-R). We assessed antigen expression, internalization, and resistance pathways, including efflux transporter …

Common Octopus (Octopus Vulgaris) Blooms Off The Southwest Of The Uk: History, Trends, Causes And Consequences.: Report On Work Package 1: History, Causes And Consequences Of Octopus Blooms, Bryce Stewart, Simon Thomas, Tim J. Smyth, Molly K. James, Emma Sullivan, Alice Hall, Tully Osmond, Emma Sheehan

School of Biological and Marine Sciences

Common octopus (Octopus vulgaris) are normally uncommon in UK waters, with a mainly south-westerly distribution linked to the species’ preference for warmer conditions. However, a major population bloom occurred off southwest UK in 2025, comparable to rare historical blooms recorded in 1899–1900, 1932–33 and 1950–51. The species’ rapid growth, high fecundity and short lifespan make its populations highly responsive to environmental conditions. Evidence from fisheries landings, scientific surveys and citizen science confirmed the bloom, with commercial fisheries landings of common octopus in 2025 being almost 65 times higher than recent annual averages. The 2025 bloom and all previous blooms were …

A Bovine Cell Line Resistant To Japanese Encephalitis Virus Entry But Permissive To Post-Entry Replication, Sang-Im Yun, Young-Min Lee

Animal, Dairy, and Veterinary Science Faculty Publications

Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic orthoflavivirus that poses a significant global health threat. It causes severe neuroinflammatory disease in humans and reproductive failure in swine. Because of the broad host range and cell tropism of JEV, identifying animal cell lines resistant to infection has been a persistent challenge. In this study, we demonstrate that Madin–Darby bovine kidney (MDBK) cells are resistant to JEV infection yet remain fully permissive to viral replication when transfected with viral genomic RNA. Using immunoblotting, immunofluorescence, and flow cytometry, we show that MDBK cells, unlike the highly susceptible baby hamster kidney (BHK-21) cells …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Mechanistic Insights Into The Antimicrobial Effect Of Benzodioxane-Benzamides Against Escherichia Coli, Lorenzo Suigo, Alessia Lanzini, Valentina Straniero, William Margolin

Faculty, Staff and Student Publications

Background/Objectives: The bacterial cell division machinery is emerging as an attractive target for antimicrobial compounds. FtsZ, a highly conserved essential division protein, is the target for a number of small molecules such as benzamides. Recent studies show that benzodioxane-benzamides (BDOBs) are among the most potent inhibitors of FtsZ function in Gram-positive bacteria, although their ability to inhibit Gram-negative FtsZ, in particular Escherichia coli FtsZ, has been more controversial.

Methods: Here, we use genetic and cytological methods to demonstrate that FtsZ of efflux pump-disabled E. coli can be efficiently targeted by BDOBs.

Results: We show that engineered mutants …

Liturgies Of The Self: Contemporary American Cult Fiction, Identity, And Narrative Evangelism, Kerry Hillis Goff

Electronic Theses and Dissertations Archive

“Liturgies of the Self: Contemporary American Cult Fiction, Identity, and Narrative Evangelism,” examines how American novels from 1980 to the present stage cultic logic as a cultural grammar of belonging. Across two cohorts—1980–2000 and 2001–present—the project demonstrates how narratives of consumerism, violence, embodiment, race, and simulation reveal identity as liturgical performance rather than autonomous selfhood. The first cohort—Don DeLillo’s White Noise (1985), Chuck Palahniuk’s Fight Club (1996), Bret Easton Ellis’s American Psycho (1991), Douglas Coupland’s Generation X (1991), and Katherine Dunn’s Geek Love (1989)—dramatizes cultic rituals through spectacle, grotesque display, and overt performance. DeLillo stages consumer spectacle as collective liturgy; …

Coexisting Salps Exhibit Distinct Feeding Selectivity On Microorganisms In The North Pacific Subtropical Gyre, Anne W. Thompson, Kylee Lamberson, Kelly R. Sutherland

Biology Faculty Publications and Presentations

Mortality mechanisms play an important role in how oceanic microorganisms contribute to global biogeochemical cycles. Salps are widespread pelagic tunicates known to remove phytoplankton from coastal and high-latitude waters, but their interaction with microorganisms in the vast tropical and subtropical gyres is not well quantified. Using quantitative measurements of six major marine microorganisms in the guts of six distinct but co-occurring salp species from the North Pacific Subtropical Gyre, we examined the impact and dynamics of salp feeding on marine microorganisms in a vast open ocean region. All salps preferentially removed prey greater than 1 μm in diameter, including marine …

Thinking Otherwise With Children In Cities: A Storying Approach To Co-Researching With Children And Teachers, William A. Parnell, Sally Guyon

Leadership, Learning and Counseling Faculty Publications and Presentations

This Children in Cities research project examines an approach to storying research that foregrounds collaborative meaning-making between educators and young children in their city. Through exploring how educators and young children might “think otherwise” about teaching, learning, and participation with history, Place noticing and entanglements between humans, more-than-human, and non-humans, three stories and a metaphor surface in the data. Drawing on three stories, metaphor is employed as an analytic and integrative device to deepen interpretation of lived experiences. Central to the methodology is a democratic orientation that seeks to reduce hierarchical boundaries, engaging children aged 3–5 as co-researchers in the …

Educational Design Models In Transition: A Comparative Review, Tofan Stofiana, Yeti Mulyati, Andoyo Sastromihardjo, Dadang Sunendar

Journal of Educational Research and Practice

A persistent gap between educational theory and classroom practice underscores the need for methodological approaches that are reflective, participatory, and context responsive. This study provides a comparative review of four major educational design models, including research and development (R&D); Analysis, Design, Development, Implementation, and Evaluation (ADDIE); design-based research (DBR); and educational design research (EDR), to examine their theoretical orientations and contemporary applications. A systematic literature synthesis and bibliometric mapping were conducted on 80 peer-reviewed journal articles indexed in Scopus between 2020 and 2025. The findings reveal that ADDIE remains the most frequently applied framework due to its procedural clarity and …

Procedure To Evaluate Artificial Intelligence (Ai) Output For Educational And Clinical Tasks, Lynn Gilbertson, Cody Marie Busch, Jon Spike, Kaitlin Demoss, Jae Thompson

Teaching and Learning in Communication Sciences & Disorders

As generative artificial intelligence (AI) becomes more ubiquitous and accessible, there is a call to promote awareness, implementation, and evaluation skills among AI users. Free AI platforms offer unprecedented opportunities to transform how education and healthcare tasks are approached. However, a process for evaluating AI output has yet to be standardized. The current study implemented a structured process for guiding graduate and undergraduate students through critical evaluations of various AI platforms, promoting students' critical thinking and career readiness.

Effects Of Infused Instruction On Graduate Students’ Knowledge, Self-Perceptions, And Misconceptions Of African American English Dialect, Virginia L. Dubasik, Tim Brackenbury, Jasmine I. Wilson

Teaching and Learning in Communication Sciences & Disorders

Despite guidelines and requirements for training programs in communication sciences and disorders (CSD), pre-service and practicing speech-language pathologists report feeling under-prepared to work with speakers of Nonmainstream American English (NMAE) dialects such as African American English (AAE; Latimer-Hearn, 2020). The current study explored explicit instruction of the phonological and syntactic characteristics of AAE via infused instruction with speech-language pathology graduate students. Participants were 43 first- and second-year students in a CSD program. At the start of the course, participants completed a pre-instruction survey containing questions regarding demographics, exposure/experiences with AAE, baseline knowledge of AAE characteristics, and misconceptions regarding the dialect. …

Review Of "Canada And The Korean War: Histories And Legacies Of A Cold War Conflict" Edited By Andrew Burtch And Tim Cook, Tod Strickland

Canadian Military History

Review of Canada and the Korean War: Histories and Legacies of a Cold War Conflict edited by Andrew Burtch and Tim Cook

Review Of "The Age Of The Gas Mask: How British Civilians Faced The Terrors Of Total War" By Susan R. Grayzel, Kyle Pritchard

Canadian Military History

Review of The Age of the Gas Mask: How British Civilians Faced the Terrors of Total War by Susan R. Grayzel

Time And Again, Christopher Buckley

Creative Nonfiction Magazine

No abstract provided.

Minding Machines: A Note On Alienation, Sascha Engel

Fast Capitalism

This paper discusses an underrepresented dimension of contemporary alienation: that of machines, and particularly of computing machines. The term 'machine' is understood here in the broadest sense, spanning anything from agricultural harvesters to cars and planes. Likewise, 'computing machine' is understood broadly, from homeostatic machines, such as thermostats, to algorithmic universal machines, such as smartphones. I suggest that a form of alienation manifests in the functionalist use and description of machines in general; that is, in descriptions of machines as mere tools or testaments to human ingenuity. Such descriptions ignore the real and often capricious existence of machines as everyday …

The Solace Of The Sojourn: Towards A Praxis-Oriented Phenomenological Methodology And Ethics Of Deep Travel In Martin Heidegger's Sojourns

Fast Capitalism

This article focuses on Martin Heidegger's little read travel journal, Sojourns (1962), and explores how it yields surprisingly fruitful insights into our contemporary era of neoliberal globalization via its implicit exploration of the complex interconnections between travel, phenomenology, and ethics. Specifically, I posit that Sojourns contains an implicit praxis-oriented phenomenological methodology and ethics of global travel that together gesture towards a coherent practice of "deep travel," which American literature scholar Cinzia Schiavini aptly defines as "a vertical movement in a closed space which starts from the surface of the land and goes backward in time, searching for the hidden social …

Bound To Capitalism: The Pursuit Of Profit And Pleasure In Digital Pornography, Jennifer Miller

Fast Capitalism

This paper explores digital pornography dialectically through a case study of Kink.com, an online BDSM subscription service. It considers the tension between discourses of authenticity that seek to obscure profit motive and shifts in content prompted by market considerations.

Author Biography

Jennifer Miller, University of Texas at Arlington

Jennifer Miller is an interdisciplinary scholar and cultural theorist who researches children's picture books. She has published in the Journal of Homosexuality, the edited collection Heroes, Heroines, and Everything in Between, and is currently working on a book length project under contract with the University Press of Mississippi.

The Twilight Of Automation, Mario Khreiche

Fast Capitalism

The future of work has come under renewed scrutiny amidst growing concerns about automation threatening widespread joblessness and precarity. While some researchers rush to declare new machine ages and industrial revolutions, others proceed with business as usual, suggesting that specialized job training and prudent reform will sufficiently equip workers for future employment. Among the points of contention are the scope and rate whereby human labor will be replaced by machines. Inflated predictions in this regard not only entice certified technologists and neoclassical economists, but also increasingly sway leftist commentators who echo the experts' cases for ramping up the proliferation of …

Divining Domination: Steve Bannon As A Political Mystagogue, Tony Allen Feldmann

Fast Capitalism

Right-wing commentators (on tv, radio, newspapers, documentaries, or the internet) are often considered a source of misinformation and radicalization in American politics. Understanding the role of such commentators in the political sphere has taken on new significance since the election of Trump, who regularly takes talking points as well as political advice from prominent figures in right-wing media. The purpose of these political "shock jocks" also extends beyond mere political commentary: They offer their audience a framework for understanding the world. This framework contains certain reified perceptions of society and history. Durkheim and those working in his tradition have long …

Hamlet's Father: Hauntology And The Roots Of The Modern Self, Lukas Szrot

Fast Capitalism

In his 1949 work Hamlet's Ghost, Richard Flatter wrote of the ghost of Hamlet's father that the play ultimately belongs to him, to the ghost.   Modernity, like the play, belongs to its ghosts, to its dead fathers haunting their wayward sons, the metaphysical specters it imperfectly endeavors to exorcise. Critical theory has often focused on the possibility, and the contours, of a utopia populated by liberatory spirit and liberated persons. Less well explored, however, are the implications for tradition, religion, and the transmission of culture at a metaphorical echelon—those ostensibly "pre-modern" ideas which the broader project of Enlightenment liberalism never …

Full Issue, Fast Capitalism Editorial Team

Fast Capitalism

No abstract provided.

Front Matter, Fast Capitalism Editorial Team

Fast Capitalism

No abstract provided.

The Tragedy Of The Commonplace: Clichés In The Age Of Copyright, Jakob Norberg

Fast Capitalism

No abstract provided.

The East As A Theatre House Of Suffering: ‘Suffering’ Scholarship And The Orientalist Bind, Yasmin Ibrahim

Fast Capitalism

No abstract provided.

Social Movement Uses Of Capitalist Infotainment, Jl Johnson

Fast Capitalism

No abstract provided.