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Dual Tyk2/Jak1 Inhibition By Brepocitinib Reprograms Synoviocyte Pathobiology: Mechanistic Insights Into Targeted Therapy For Rheumatoid Arthritis, Umar Saeed, Zahra Zahid Piracha, Andromeda M. Nauli, Surya M. Nauli

Pharmacy Faculty Articles and Research

Background:

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial hyperplasia, persistent inflammation, and joint destruction. Targeted inhibition of intracellular signaling pathways, such as JAK-STAT, has improved RA treatment outcomes, though safety and selectivity remain as concerns. Brepocitinib, a dual TYK2/JAK1 inhibitor, has shown clinical efficacy in the management of autoimmune diseases, yet its mechanistic impact on synoviocytes remains underexplored.

Objectives:

To investigate the molecular and functional effects of brepocitinib on MH7A and RA-FLS synoviocytes, a key effector cell type in RA pathogenesis.

Methods:

MH7A and RA-FLS cells were treated with brepocitinib (0.5 µM, 1 µM, and 5 …

Russia’S Soft Power In Nahdlatul Ulama’S Art Exhibition Russia-Indonesia: Within The Framework Of Art, Nurul Rahmawati, Ahmad Fahrurodji

International Review of Humanities Studies

This study analyzes the construction of Russian cultural diplomacy in news media coverage of art exhibitions. Russia-Indonesia: Within the Framework of Art. The research uses the method Critical Discourse Analysis with Norman Fairclough's model and concept soft power Joseph Nye and the skeleton Taxonomy of Soft Power from Ohnesorge to map actor relations in cultural diplomacy practices. The results show that Russia utilizes art, religious symbols, and collaboration with Nusantara Utama Gallery and the involvement of Nahdlatul Ulama (NU) artists as an instrument of soft power to build appeal and legitimacy among the Indonesian Muslim public through cross-media discourse …

Rules Before Relief: International Organizations And The Administrative Burdens Of G5 Donor Counterterrorism And Sanctions Frameworks In The Mena Region, Khloud Awad

Theses and Dissertations

The international humanitarian system relies on a small group of powerful donor governments. The G5, the United States, the United Kingdom, Germany, France, and Japan, collectively provide the majority of bilateral humanitarian financing and attach extensive counterterrorism and sanctions compliance requirements to their funding. This study examines how these frameworks generate administrative burden for the international organizations that translate funding into assistance in conflict settings in the MENA region. The study draws on Administrative Burden Theory, adapted from its original citizen-state context to the donor-international organization relationship. Moreover, it adopts a qualitative design across four conflict-affected settings: Sudan, Palestine, Syria, …

Literature Review: Crowdfunding And Political Fundraising, Saiful Ahmad, Palupi Lindiasari Samputra

Journal of Strategic and Global Studies

Crowdfunding is an effort to raise relatively small amounts of money involving many individuals to support a specific project. Typically, crowdfunding is conducted online through fundraising platforms. The aim of this paper is to identify and analyse the utilisation of crowdfunding in fundraising activities that are related to or have political goals carried out by certain organisations or political groups. The method used in this paper is qualitative in the form of narrative analysis carried out through in-depth reading of several scientific literatures that discuss political fundraising through crowdfunding. The sources of scientific literature collection were obtained through the Google …

How A Stay-At-Home Father Plays A Role In Family Resilience?, Fatimah Fatimah, Eko Daryanto

Journal of Strategic and Global Studies

One of the impacts of modernization is the loss of barriers between job and particular gender. This also happens in the family unit, more specifically in the role of husband and wife. The husband's job which is identical to earn money and the wife's job is to manage the household should be able to be done more flexibly according to family conditions. This adaptation process is needed in order to strengthen family resilience. Non-traditional family composition that usually consist of a stay-at-home father and a working mother can be used as a family adaptation strategy. This study uses the results …

Implementation Of Zero Trust Architecture On Local Server Management In Educational Institutions, Joko Purwanto, Safar Dwi Kurniawan

Journal of Strategic and Global Studies

Educational institutions are facing increasingly complex cyber threats, particularly as they continue to rely on on-premises servers with limited cybersecurity resources. Zero Trust Architecture (ZTA) offers a security model that rejects implicit trust and requires strict verification of each access request. This study aims to examine the applicability of ZTA in managing local servers within educational institutions through a qualitative literature review approach. Relevant literature from 2014 to 2025 was analyzed using thematic synthesis to identify recurring concepts, strategies, and gaps. The results show that ZTA, when integrated with Identity and Access Management (IAM), Security Information and Event Management (SIEM), …

Securitization Of The Forced Labor Issue Of Indonesian Migrant Fishing Vessel Crew By The Ministry Of Foreign Affairs, Lu'lu' Mamluatul Hikmah Ladienda, Nur Luthfi Hidayatullah

Journal of Strategic and Global Studies

The case of forced labor against Indonesian migrant fishing vessel crew members has put the government in a dilemmatic position. The Indonesian government acts both as a labor sender and the protector of citizens' rights overseas. This study aims to examine how the Ministry of Foreign Affairs of the Republic of Indonesia raises the issue of forced labor as an existential threat through a securitization process. Using a descriptive qualitative approach, data was obtained from semi-structured interviews with officials of the Directorate of Indonesian Citizen Protection, as well as analysis of official documents, public statements, and credible media sources. The …

China’S Health Diplomacy To Asean Through Asean-China Comprehensive Strategic Partnership 2021-2025, Zahra Shaffa Kamila, Deasy Silvya Sari

Journal of Strategic and Global Studies

The world always faces limitations in dealing with the pandemic. China had emerged as an active actor in health diplomacy to address this. China was the first country to send vaccines and health aid to Southeast Asia through ASEAN. However, the relationship between China and ASEAN did not begin with the pandemic. Both countries have a long history and recently renewed their plan of action (POA), which serves as evidence of their relationship namely the ASEAN-China Comprehensive Strategic Partnership (CSP) 2021-2025. The POA includes a sub-chapter on health that navigates China's health diplomacy towards ASEAN. Therefore, this research aimed to …

The Satu Wakaf Indonesia Application Development Strategy, Nurul Huda, Nova Rini, Rahma Aini Nur, Ariel Nian Gani, Muhammad Rofi'i, Nur Syamsudin Buchori

Journal of Strategic and Global Studies

The Satu Wakaf Indonesia application is a new platform for digital waqf, which necessitates a strategic policy for its development. The needs of strategic policy stand from the current problems that occur in the implementation of the application. The objectives of this study are: (1) the key sub-elements of the Satu Wakaf Indonesia development strategy, and (2) The Satu Wakaf Indonesia development strategy using the ISM approach. The research method used is a qualitative method with the Interpretive Structural Modelling (ISM) approach. The data source for this study is the results of filling out questionnaires by expert informants. The results …

Humanity Is Evolving Its Consciousness: The Role Of Archetypal Energies As Guides During An Unfolding Weeding Out And Alignment Process, Carroy U. Ferguson

Psychology Faculty Publication Series

Humanity is evolving its consciousness at individual and collective levels.  Given these seemingly tumultuous times, as of this writing (January 2026), to make such a statement may sound like a strange thing to say.  However, I suggest that if you are alive today and if you are reading these words, these are the very times for which you were born—to assist Humanity as it evolves its consciousness with your unique gifts, whatever they may be.  That is, this period of our individual and collective human being-ness may be characterized as an unfolding period of weeding out and alignment with the …

Private Sector Healthcare Investment In Indonesia: Leveraging Australia-Indonesia Partnerships For Health System Transformation, Susan Josephine Neuhaus

Journal of Indonesian Health Policy and Administration

Australia and Indonesia are strategic partners with expanding bilateral trade valued at AUD 26.7 billion (2022-23). Health care partnerships between the two countries offer significant opportunities for private sector engagement. Indonesia’s large population, rapidly growing middle class, and implementation of Universal Health Coverage (UHC) through the Jaminan Kesehatan Nasional (JKN) present partnership opportunities to strengthen health system capacity, address infrastructure gaps and workforce shortages, and contribute to shared economic and prosperity goals. This study explores how Australian private healthcare investment can complement government initiatives in supporting Indonesia’s UHC while advancing Australia’s regional engagement. A descriptive qualitative analysis was conducted using …

Analysis Of Coverage Of Tuberculosis Prevention Therapy (Tpt): Literature Review, Septia Rahmalina, Ede Surya Darmawan

Journal of Indonesian Health Policy and Administration

Tuberculosis Preventive Therapy (TPT) is a crucial intervention for tuberculosis (TB) control, particularly among high-risk groups such as household contacts of TB patients and people living with Human Immunodeficiency Virus (HIV). Despite being recommended by the World Health Organization (WHO), TPT implementation still faces challenges at the primary care level. This study employed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method to review 11 articles published between 2021 and 2025 that were relevant to TPT implementation in various high-TB burden countries, including Indonesia. The main barriers identified were input (logistics, training), process (tracing, education, monitoring), and output …

Debating The Self-Pardon: A Dialogue Of The Evidence For And Against The Constitutionality Of A Presidential Self-Pardon, Michael Conklin, Peter B. Bayer

Missouri Law Review

In light of recent events, the constitutionality of presidential self-pardons is set to potentially become one of the most pressing constitutional questions of the twenty-first century. This Article consists of a dialogue between two scholars regarding the evidence for and against the constitutionality of presidential self-pardons. By providing their best arguments for and against each side, readers are left better equipped to reach their own educated conclusions. The benefits of discussing this issue before anyone attempts to self-pardon are considerable, as doing so could contribute to solutions, potentially averting, or at least helping to resolve peaceably, a true constitutional crisis. …

Microplastics In St. John, United States Virgin Islands Sediments: Methodological Approaches And Variability Of Microplastics Concentrations And Accumulation Rates, Henry B. Arbaugh, Sarah C. Gray, Dimitri Deheyn

Theses

Sediment samples were collected from a near shore and reef site in Coral Bay, St. John, United States Virgin Islands (USVI) from 2007-2016, using tube sediment traps. These samples provide an opportunity to study microplastics (MPs) in an area where no previous MP studies have been performed. Most sedimentary MP studies utilize benthic samples which can only measure MP concentrations (#MP/g or #MP/mL sediment), while sediment traps can provide MP accumulation rates (#MP/cm²/day) as a function of time. However, the methods used for extracting MPs from benthic samples have not been tested using sediment trap samples whose characteristics, …

Teachers’ Perception And Challenges Of Online Education In Uae: A Quantitative Study, Ghadah Al Murshidi, Laila Mohebi, K. Kavitha, Roohi Kursheed Khan, Ahmed Al Zaabi

All Works

This study analyzes survey data from teachers in UAE educational institutions to examine their perceptions towards the benefits and challenges of online learning, with a focus on student engagement, technical barriers, and instructional effectiveness. In light of changing educational paradigms, the study examines teachers’ perceptions of online learning success and the challenges it presents, including technical issues, concerns about student involvement, and academic integrity. A survey was conducted among teachers in the UAE to gather data on online education, ensuring representation across genders, age groups, educational backgrounds, and geographic areas. The study highlights the benefits of online learn-ing, including its …

Fly Ash Proppant Developed For Hydraulic Fracturing, Raz Rzgar Haydar

Theses and Dissertations

Proppants are critical components in hydraulic fracturing, used to maintain fracture conductivity and enhance reservoir stimulation. In high-pressure and harsh reservoir environments, the use of high-strength proppants is essential to ensure well performance. Conventional proppants, being sand, ceramic, and sintered bauxite can be expensive, and their use often requires costly fracture fluids. This study investigates the possibility of utalizing fly ash geopolymers as a sustainable alternative that is also cost-effective for proppants manufacturing. Fly ash, a by-product from the combustion of coal and other materials, was explored as a base material for proppants, utilizing an alkaline solution as an activator …

Egypt’S Strategic Hedging In Economics With The United States And China From 2014-2024, Abigail Flynn

Theses and Dissertations

This research aims to explain how Egypt is able to engage economically with two internationally competitive powers, the United States and China, using the theoretical framework of strategic hedging in the period of 2014-2024. While existing literature on strategic hedging is primarily focused on Southeast Asia and broadly deals with political hedging, this study applies the framework specifically to Egypt and is limited to economic relations. This research is significant because it identifies how Egypt is able to increase its economic engagement with the U.S. and China despite their competitive status and offers a novel argument which can be tested …

Assessing School Readiness For Social And Emotional Learning: A Study Of School Leadership Perceptions And Attitudes, Nahla Elharati

Theses and Dissertations

This study explores the integration of social and emotional learning (SEL) in a number of British schools across Egypt, focusing on how school leaders defined and perceived its importance in student development. Through in-depth interviews with twelve school leaders, this study found that school leaders’ definitions of SEL emphasized self- awareness, self-regulation, and relationship-building, alongside a strong focus on the real-life applicability of SEL both within school settings and in students’ future lives. School leaders also expressed positive attitudes toward the benefits of SEL, particularly its role in enhancing academic performance, promoting student well-being, improving peer relationships, and reducing bullying, …

A Virtual-Reality-Based Dental Simulator For Endodontics With Automated Formative Feedback, Yousef Salah Abo El Ela

Theses and Dissertations

Advancements in virtual reality (VR) and haptic technology are transforming the landscape of medical and dental education, offering new avenues for safe, immersive, and repeatable training experiences. Within dentistry, endodontics presents unique challenges for preclinical education due to anatomical complexity, limited access to extracted teeth, ethical concerns, and the shortcomings of conventional plastic models. Despite endodontics specific plastic teeth being available, they fall short of replicating the hardness of real extracted teeth, are relatively costly compared to generic plastic teeth, and are ultimately a disposable item which makes them inadequate as a sustainable long-term solution. Extracted teeth do a much …

Targeting The Cd47/Calreticulin Axis In Triple Negative Breast Cancer Using Ha Grafted Chitosan Nanoparticles Loaded With Doxorubicin And Polygodial, Hadir M. Emara

Theses and Dissertations

Background: Triple-negative breast cancer (TNBC) is considered the most aggressive subtype of breast cancer. Although progress in cancer treatment has led to better results for different types of breast cancer, TNBC remains particularly challenging due to persistent resistance to both chemotherapy and immunotherapy. This resistance ultimately renders chemotherapy less effective and is frequently associated with substantial side effects. Immunosurveillance significantly impacts the onset of cancer, the rise of resistance to therapies, and the likelihood of tumor recurrence. In this immunomodulatory process, Cluster of Differentiation 47 (CD47) and Calreticulin (CALR) are two key regulators. CD47 expression is strongly linked to anti-phagocytic …

Students' Perceptions Of English Pop Culture, Andrew Ruffing

Theses and Dissertations

Abstract

The purpose of this study is to investigate AUC students’ perceptions of English pop culture. Literature has shown that pop culture can be a beneficial engaging resource for students in the classroom. It provides students with comprehensible input for the language. However, there are concerns that students are disproportionately exposed to American pop culture while learning English. The purpose of this study is to investigate what nation students typically associate with English pop culture as well as if they use it to connect with those around them or the world outside their culture, as well as investigating their perceptions …

Pengaruh Real Mismatch Terhadap Upah Pekerja Di Indonesia, Jawani Eka Pyansahcilia, Dwini Handayani

Jurnal Ekonomi Kependudukan dan Keluarga

This study aims to analyze the effect of real mismatch on the wages of workers with medium and higher education levels in Indonesia using the ordinary least squares (OLS) method. The data used in this study are derived from the National Labor Force Survey (Sakernas) conducted in August 2023 to identify instances of mismatch and analyze its impact on workers' wages. In 2023, the incidence of vertical mismatch only was recorded at 14.58 percent, horizontal mismatch only at 31.73 percent, and real mismatch reached 25.24 percent. The estimation results indicate that workers experiencing vertical mismatch only receive a wage premium, …

Higher-Order Moment Risk Spillovers Between The Carbon And Energy Markets Under Climate Policy Uncertainty, Qiang Ji

Double Helix Methodology

Against the backdrop of increasing climate policy uncertainty, preventing cross-market risk contagion in the energy transition is crucial to ensuring energy security and effective risk management. First, this study uses the generalized autoregressive conditional heteroskedasticity-skewness-kurtosis (GARCHSK) model to measure the higher-order moment risk of the carbon and energy markets. Then, based on the quantile spillover index model, the higher-order moment risk spillover effects and their time-varying characteristics in different risk states are characterized. Furthermore, the climate policy uncertainty index (CPU) is incorporated into the generalized autoregressive conditional heteroskedasticity-mixed data sampling (GARCH-MIDAS) model to analyze its impact on higher-order moment risk …

Interpersonal Satisfaction And Classroom Silence In Chinese Universities: The Mediating Role Of Social Anxiety, Siguang Zhang

Double Helix Methodology

Introduction: Within Chinese universities, classroom silence, while culturally acceptable, may indicate underlying psychological distress that impedes academic engagement. Drawing upon social-cognitive theory, this study investigates whether social anxiety mediates the relationship between interpersonal satisfaction and students’ in-class silence. Methods: A cross-sectional survey of 565 undergraduates from six Chinese universities examined interpersonal satisfaction, social anxiety, and three distinct behavioral indicators of silence (large-lecture, small-discussion, and laboratory contexts). Confirmatory factor analysis established convergent and discriminant validity; Cronbach’s α coefficients ranged from 0.86 to 0.91, demonstrating good internal consistency. A structural equation model (SEM) was employed to test the hypothesized mediation pathway while …

Multifunctional Green Wall Systems For Greywater Treatment And Hygrothermal Regulation In Egypt, Laila Ossama Mohamed Elhusseiny Abdelsalam

Theses and Dissertations

Increasing environmental concerns regarding climate change and the intensifying challenge of water scarcity in Egypt necessitate the development of innovative, sustainable, and resource-efficient strategies for wastewater reuse. In the built environment, greywater constitutes a significant, relatively low-contaminant wastewater stream that, if treated to comply with Egyptian Codes and relevant international standards, can be safely reused for non-potable applications such as irrigation, landscaping, and building services. This research investigates the efficacy of an integrated green wall panel system, installed on building façades, for decentralized greywater treatment under Egypt’s climatic and environmental conditions, while simultaneously enhancing hygrothermal performance to reduce building energy …

Evolving Skills And Stakeholder Dynamics: Investigating The Transformative Influence Of Generative Ai On Egyptian Public Policy, Zeinab Hosny Abdelgawad

Theses and Dissertations

Since its public release in November 2022, OpenAI's Generative AI (GenAI) has been met with varied responses, from widespread individual adoption to institutional caution. This phenomenon is evident among Egyptian public policy makers, where some institutions quickly embraced GenAI, while others have been slow to integrate it. The adoption of GenAI among these professionals is influenced by multiple factors, with institutional factors and budget constraints being the most significant. The varied adoption creates a need for new skills and the enhancement of existing ones. This uneven adoption is hypothesized to cause two main issues in Egyptian public policy: a policy …

Family Caregivers And Suicide Prevention: A Needs And Assets Assessment In Egypt, Lina Osama Allam

Theses and Dissertations

In the Arab world, suicide prevention is shaped by cultural stigma and religious beliefs, shaping both help-seeking behaviors and the design of support systems. Family caregivers play a vital role in suicide prevention but often face significant emotional and logistical burdens. This study is the first known scholarly effort in Egypt to examine the intervention needs of these caregivers. It explored three key questions: the roles and challenges of caregivers supporting individuals with suicidal thoughts or behaviors; the availability of clinical and community-based resources; and the characteristics of future interventions to support them. A total of 92 mental health professionals …

An Impact Assessment Of The Effectiveness Of Utilizing Informal Health Communication Interventions To Spread Health Recommendations And Change Public Perception, Lina Mohamed Ezzat Ahmed Abdel Mawgoud

Theses and Dissertations

Brain health is an increasingly urgent but critically under-addressed public health priority in Egypt and the wider MENA region. Despite its centrality to aging, productivity, and overall quality of life, public understanding of brain health remains limited, and stigma continues to shape responses to dementia and cognitive decline. This study evaluates the effectiveness of informal, culturally adapted health communication as a tool to shift perception, increase awareness, and promote behavior change among non-medically trained adults in Egypt.

Grounded in global evidence on cognitive reserve, neuroplasticity, and the life-course approach to brain health, the intervention translated expert-informed brain health recommendations into …

Domestic Violence Againts Women In Thailand: Galtung-Based Analysis Of Violence In Thai Drama “Tie Me (K)Not”, Akhdiat Dimas Abimanyu, Rahadjeng Pulungsari

International Review of Humanities Studies

This study examines the portrayal of domestic violence against women in the Thai drama Tie Me (K)not (2022) using Johan Galtung’s theory of violence, which categorizes violence into direct, structural, and cultural forms. Through qualitative content analysis, the research identifies how the drama depicts these forms of violence, reflecting broader societal issues in Thailand. The findings reveal explicit instances of direct violence, such as physical and psychological abuse, systemic structural violence through institutional failures in justice and support systems, and cultural violence rooted in patriarchal traditions that justify gender inequality. The drama not only highlights these oppressive dynamics but also …

Statute Meets Custom: Explaining Provincial Variation In Child Marriage After Indonesia’S 2019 Reform, I Made Yudisthira, Diahhadi Setyonaluri

Jurnal Ekonomi Kependudukan dan Keluarga

This study investigates whether Indonesia’s 2019 Marriage Law reform, which raised the minimum legal age of marriage to 19, has been associated with lower child marriage prevalence. Using province-level aggregates from the 2022 Indonesian National Socio-Economic Survey (SUSENAS, N = 1,237,946), we distinguish documented and undocumented unions and estimate Ordinary Least Squares models with controls for poverty, education, assets, rural residence, religious composition, and marriage dispensations. Descriptive maps show prevalence is highest in South Kalimantan (18%), East Java (17%), and West Java (17%), with undocumented unions concentrated in West Nusa Tenggara (7%), Banten (5%), Papua (5%), and West Sulawesi (5%). …