Digital Commons Network^™

Modulating Alternative Splicing Of Mecp2 Is A Potential Therapeutic Strategy For Rett Syndrome, Harini P Tirumala, Li Wang, Yan Li, Sameer S Bajikar, Ashley G Anderson, Wei Wang, Alexander J Trostle, Mahla Zahabiyon, Aleksandar Bajic, Jean J Kim, Hu Chen, Zhandong Liu, Huda Y Zoghbi

Faculty, Staff and Students Publications

Rett syndrome (RTT) is a neurological disorder caused by loss-of-function mutations in methyl CpG binding protein 2 (MECP2), a transcriptional regulator essential for maintenance of normal neuronal function. The current FDA-approved treatment for RTT, Trofinetide, mildly alleviates some symptoms. In contrast, re-introducing MeCP2 or increasing its amount through transgenesis in mouse RTT models improves most neurological phenotypes and enhances survival. Here, we devised a therapeutic strategy to moderately increase MeCP2 protein by modulating the alternative splicing of MECP2 to switch the less efficiently translated e2 to the more efficiently translated e1 isoform. We deleted Mecp2 exon 2 (unique …

Sodium Content Of Packaged Foods And Beverages In Nigeria: A Cross-Sectional Comparative Study With Who Global Sodium Benchmarks, Kenya, And South Africa, Adedayo E Ojo, Alexandra Jones, Kylie Howes, Vanessa Alfa, Anthony Orji, Oluwafemi A Stephen, Carla Pool, Alex Kibet, Fraser Taylor, Diederick E Grobbee, Bruce Neal, Mark D Huffman, Dike B Ojji, Sanne A E Peters

2020-Current year OA Pubs

High intake of processed foods, especially those with high sodium content, is a contributor to hypertension and cardiovascular disease. This study aimed to compare the sodium content of packaged foods and beverages in Nigeria to WHO Global Sodium Benchmarks and similar products in Kenya and South Africa. The study examined packaged foods from major retail stores in the capital cities of the Federal Capital Territory, Kano, and Ogun states in Nigeria from November 2020 to March 2021. Benchmark values were based on the 2021 WHO Global Sodium Benchmarks. We used secondary data from packaged food surveys conducted in South Africa …

Akibat Yuridis Dari Suatu Perkawinan Di Bawah Tangan, M. Idris Ramulyo, S.H.

Jurnal Hukum & Pembangunan

Abstract

Akibat Yuridis Dari Suatu Perkawinan Di Bawah Tangan, M. Idris Ramulyo, S.H.

Jurnal Hukum & Pembangunan

Abstract

Apa Dan Bagaimana Berita Negara Republik Indonesia, Kuneng Mulyadi, S.H.

Jurnal Hukum & Pembangunan

Abstract

Pemanfaatan Tanah Hak Guna Usaha Dalam Rangka Penanaman Modal Asing, Arie Sukanti Sumantri

Jurnal Hukum & Pembangunan

Abstract

Volume 12, 2025

James Madison Undergraduate Research Journal (JMURJ)

No abstract provided.

Geography Of Periodical Cicadas (Hemiptera: Cicadidae) In Portions Of Northeast Illinois And Northwest Indiana, Carl A. Strang

The Great Lakes Entomologist

Brood XIII periodical cicadas (Magicicada Davis) in DuPage County, Illinois, emerged in 2024 in an area that extended as much as 10.6 km beyond the edge of the previous main emergence in 2007. The implied dispersal of gravid females is greater than has been reported elsewhere and may reflect adaptation to a historical landscape of scattered wooded islands within a matrix of prairie. A series of four-year-early emergences in northeast Illinois, first described in print in 1969 and subsequently occurring prior to each succeeding main emergence, was quantified for the first time in 2020. The largest densities of singing …

Cover Pages For Tgle Vol. 58 Nos. 3 & 4

The Great Lakes Entomologist

Cover pages for TGLE Vol. 58 Nos. 3 & 4

Full Issue For Tgle Vol. 58 Nos. 3 & 4

The Great Lakes Entomologist

Full issue for TGLE Vol. 58 Nos. 3 & 4

“Today’S Video Is Sponsored By: Child Labor” The Need To Expand Federal Child Labor Protections To Online Content Creation, Zayda Torres Barrios

St. John's Law Review

(Excerpt)

The Fantastic Adventures YouTube channel, owned by Machelle Hobson, had grown to almost 800,000 subscribers and over 250 million views by 2019. The channel’s content featured Hobson’s seven adopted children in entertaining weekly ten-to-fifteen-minute skits where they did things like pretend to be superheroes and have lightsaber battles. However, things were not as blissful as they seemed as Hobson was arrested in March 2019—facing thirty child abuse related charges. The police said the children were “malnourished” and had been withdrawn from school for many years to have more time to film videos for their family channel. The probable cause …

Ladies First? The Tax Code Says Otherwise Tax Policy And The Cost Of Economic Dependence, Doron Narotzki, Tamir Shanan

St. John's Law Review

(Excerpt)

First, inclusion and equity policies—such as anti-discrimination laws, affordable childcare, or education access—increase people’s participation in the labor market and thus increase federal and state revenues. Second, ultimately, tax law is not just a mechanism for raising revenue. It actively shapes economic and social realities. By acknowledging the ways in which it has reinforced outdated structures, we can also recognize its untapped potential. If designed differently, tax policy could—and should—serve as more than just a fiscal tool. It could foster economic autonomy, address inequalities, better reflect the needs of a changing society which includes, among other factors, a transition …

The Authoritarian Semiotics Of The New Campus Mask Bans, Rob Kahn

St. John's Law Review

(Excerpt)

In 2024, students took part in protests for and against Israel’s military actions in Gaza. Some protests were disruptive and violent— most were not. In response, calls arose across the country to ban masks. In New York, a broad organization of civil rights groups called for a statewide mask ban under the hashtag #UnmaskHateNY, while New York Governor Kathy Hochul—with the support of New York City Mayor Eric Adams—called for a mask ban on the New York City subways. There were also calls in North Carolina and Los Angeles for new, or enhanced, mask bans. Meanwhile, Ohio’s Attorney General …

We May Need To Run A Few More Tests: Artificial Intelligence In Medicine Is Here And What Should Happen If Dr. Robot Makes A Mistake, Jenna Hidalgo

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Breaking The Cycle Of Violence: Transitional Justice For El Salvador In The Shadow Of Authoritarianism, Marsha Pimentel

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

The Due Diligence Standard For Preventing Trans Boundary Cyber Harm: Expectation Or Obligation?, Dafina Bucaj

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Prevalence And Determinants Of Perceived Stress Among Undergraduate Respiratory Therapy Students In Saudi Arabia, Abdulmajeed A. Baogbah, Ralph D. Zimmerman, Laryssa D. Frederick, Corinne M. Hathaway

Internet Journal of Allied Health Sciences and Practice

Background: Stress is a common phenomenon among health sciences students, severely impacting students in different ways. Similar to other students, undergraduate Respiratory Therapy (RT) students are at a high risk of stress exposure that may harm their well-being. To enhance students’ well-being, it is essential to examine the prevalence and determinants of perceived stress among undergraduate RT students. Methods: A cross-sectional study was conducted during the academic year (2023-2024) to explore the prevalence and determinants of perceived stress. Data was collected through an anonymous self-administered survey consisting of 46 questions, including demographics, the Perceived Stress Scale (PSS-14), and sources of …

Reaching Learners Where They Are: Podcasting As A Scalable Tool For The National Physical Therapy Exam Preparation, Bhupinder Singh, Rudri Purohit, Emily Gerbehy, Derek Camilleri

Internet Journal of Allied Health Sciences and Practice

Purpose: The National Physical Therapy Examination (NPTE) is a pivotal requirement for PT licensure in the US. While conventional preparation methods such as textbooks, review courses, and standardized practice exams are effective, they often pose logistical and financial challenges. Method: The COVID-19 pandemic accelerated the adoption of asynchronous, on-demand educational tools. Among these, podcasting has emerged as a promising, mobile-friendly modality, yet its usage trends and educational value for NPTE preparation remain underexplored. The purpose of this study was to analyze multiyear podcast engagement data from a high-performing NPTE-focused podcast hosted on Buzzsprout, spanning January 2020 to March 2025. Engagement …

Agreement Of Chatgpt With Clinical Practice Guidelines For Knee Osteoarthritis Treatment, Alessandra N. Garcia, Brian Neville, Bradley Myers, Lori Leineke, Karlyn Green

Internet Journal of Allied Health Sciences and Practice

Purpose: This cross-sectional study evaluated whether Chat Generative Pre-Trained Transformer (ChatGPT) GPT-3.5 and GPT-4O provide treatment information consistent with high-quality clinical practice guidelines (CPGs) for knee osteoarthritis (OA). Methods: High-quality CPGs published in the past decade were identified via PubMed and PEDro, with the search updated on November 11, 2024. Guidelines were appraised using the AGREE II tool. GPT-3.5 and GPT-4O were queried with common treatment-related questions, and their responses were compared to CPG recommendations. Two independent reviewers conducted a thematic content analysis of GPT-3.5 and GPT-4O responses using a deductive–inductive codebook, iteratively refined through consensus, to identify major themes/subthemes, …

Face And Content Validity Of A Survey Tool To Measure Perceived Barriers And Facilitators To Diabetes Management In Rural Veterans: Perspectives Of Registered Dietitians, Jameson Tade, Mary Shotwell, Ronette Lategan-Potgieter, Marty R. Jacobson

Internet Journal of Allied Health Sciences and Practice

Purpose: Type 2 diabetes mellitus (T2DM) is a major health challenge in the United States, affecting over 36 million Americans exceeding $105 billion annually in treatment-related costs.^1,2 Type 2 diabetes affects some populations more than others, including rural and veteran populations.^1,3 Registered dietitians (RDs) are an integral part of the diabetes management team, but limited literature is available to identify perceived barriers to T2DM management in military veterans who preside in rural areas. The purpose of this study was to explore face and content validity of a survey tool distributed to Veterans Health Administration (VHA) dietitians in a …

Multiple Q-Dqn Algorithm Based Rumor Control In Social Networks, Zainab Hasan, Huda Naji Nawaf

Journal of Intelligent Informatics, Networking, and Cybersecurity

Malicious rumours on social media platforms like Facebook, Twitter, and others can be widely disseminated because of social problems. It is challenging to manage a rumour once it gains growth and quickly moves throughout a network. One of the main issues with information dissemination is figuring out how to reduce the propagation of rumours within a social network. A deep reinforcement learning technique might be an effective strategy to manage the rumour issue. Deep Q learning network (DQN) has been used in the literature to mitigate rumors by selecting a blocker at each time step. In this work, the proposed …

Gli Weekly, March 3, 2026, Franke Global Leadership Initiative

GLI Weekly

Advising Information -- Beyond the Classroom Experience Planning -- BTC Scholarship Workshops -- We're recruiting a VISTA for the Franke GLI -- Graduating Senior Corner -- Flathead Biological Station Summer '26 Courses: Application Now Open! -- Food and Agriculture Organization Internship Program -- Eating with Understanding -- Bee Positive Missoula -- Kyiyo Celebration Volunteers -- VolunteerUM -- Share your International Experience from College! -- First Friday! -- Three-Part Science Communication Series -- Alice/Wonderland -- SARC, "What Were You Wearing?" -- Bear Necessities, Is it your first time on Earth? Us, too! -- Vista opportunities, including with the Franke GLI! -- …

March 3, 2026 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Victimization, Health, And Help Seeking In North Dakota: How Interpersonal Violence Shapes Physical And Mental Health, Tahmid Hassan Jeeshan

Graduate Research Achievement Day Posters

Interpersonal violence extends beyond physical assault to include psychological and/or emotional abuse that can produce substantial physical and mental health consequences. This study examines how multiple forms of interpersonal violence relate to health outcomes among North Dakotan women, focusing on differences between rural and non rural residents. We compare victimization patterns, physical and mental health status, and treatment seeking behaviors. We anticipate that rural victims will report more severe or chronic victimization yet face reduced access to and use of healthcare and victim services. By jointly considering violence type, rural versus non-rural status, health outcomes, and treatment seeking, this project …

Combinatorial Therapeutic Strategies To Combat Multidrug-Resistant Acinetobacter Baumannii, Tope A. Aderibigbe

Theses and Dissertations

Acinetobacter baumannii is an opportunistic Gram-negative pathogen that poses a significant global health threat due to its remarkable ability to acquire multidrug (MDR) and extensively drug-resistant (XDR) phenotypes. Therapeutic failures are increasingly common as strains develop resistance to nearly all available antibiotics, including carbapenems, polymyxins, and tigecycline, leaving clinicians with limited treatment options. This study aimed to investigate combinatorial therapeutic approaches capable of revitalizing antibiotic efficacy against MDR/XDR A. baumannii clinical isolates. We evaluated the synergistic potential of durlobactam-sulbactam in combination with twelve commonly used antibiotics, including amikacin, rifampin, tobramycin, tigecycline, cefiderocol, and others. Initial screening using the disc diffusion …

Minutes, Curriculum Committee Meeting, Tuesday, March 03, 2026, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.

Algorithms Of Stable Adaptive Observation Of A Multidimensional Undefinite Object, Tursunova Sadoqat Abdusalom Qizi

Chemical Technology, Control and Management

This article presents an algorithm for simultaneously estimating the parameters and state coordinates of a multidimensional control object when some of its state variables are not directly measured. The inability to measure all state variables (coordinates) of an object is a well-known drawback of identification schemes. Such conditions require the construction of adaptive state observers. This work demonstrates that when identifying the parameters of a mathematical model for an uncertain multidimensional object, the asymptotic stability of the object and the convergence of its parameters to the model parameters are ensured, provided the input vector is sufficiently informative. The construction of …

March 2026 Faculty Senate Packet, University Of Nebraska At Kearney Faculty Senate

Faculty Senate Packets

No abstract provided.

Localizing Ai Image Manipulations By Learning Generative Noise Signatures Using Diffusion Based Noise Priors, Elijah Shannon

Research Horizons Day Posters

No abstract provided.

Guard And Guard Ii: Survivabilty Of Microbes Via Sounding Rocket Launch Enviroment For Future Studies On Living Radiation Fields, Tanner Land, Samuel Arnold, Grant Quartuccio, Zaylee Rodgers, Addyson Swoner, Amy Lebleu-Debartola

Research Horizons Day Posters

No abstract provided.