Digital Commons Network^™

Identifying The Geographic Origins Of Invasive Megathyrsus Maximus In The United States Using Molecular Data, John F. Gaskin, John A. Goolsby, Marie Claude Bon, Massimo Cristofaro, Paul André Calatayud

All Peer-Reviewed Publications

Megathyrsus maximus is nonnative in the neotropics, with a tall form that is commonly used as a forage grass and a smaller-statured form that is considered invasive in south Texas, USA. Biological control researchers are challenged to find an agent that will attack the short form, but not the desirable tall form in other parts of the neotropics. We conducted molecular analyses on 155 Megathyrsus maximus samples from its native range in Africa and compared them with U.S. short-form samples to help determine the geographic origins of its invasion. We found eight distinct genotypes in 34 short-form samples from Texas …

Combined Curcumin And Luteolin Synergistically Inhibit Colon Cancer Associated With Notch1 And Tgf-Β Signaling Pathways In Cultured Cells And Xenograft Mice, Rukayat Aromokeye, Hongwei Si

Human Sciences Faculty Research

This study aimed to select a combination of curcumin and luteolin, two phytochemicals from food, at lower concentrations with a higher inhibitory effect on colon cancer growth and investigate possible molecular mechanisms of this anti-colon cancer effect. By pairwise combination screening, we identified that the combination of curcumin (CUR) at 15 μM and luteolin (LUT) at 30 μM (C15L30) synergistically suppressed the proliferation of human colon cancer CL-188 cells, but the individual chemicals had a little inhibitory effect at the selected concentrations. This result was also confirmed in other colon cancer DLD-1cells, suggesting that this synergistic inhibitory effect of C15L30 …

Research On Optimization Method Of Maintenance Decision Model Of Highway Asphalt Pavement, Lin Likuan

Journal of China & Foreign Highway

Through theoretical calculation, combined with big data statistical analysis, this paper found the boundary conditions for restoring the overall damage condition index of the pavement through the treatment of local pavement diseases. During the process of maintenance decision-making and maintenance demand analysis, based on this boundary condition, sections with poor current road conditions and those that can effectively restore the road condition level only through daily maintenance measures could be quickly screened out. Therefore, it effectively reduced the capital demand for the maintenance projects of the entire road network and improved the utilization efficiency of maintenance funds. In addition, the …

Progressive Failure Mechanism Analysis Of Loose Deposit Slope Under Seismic Load, Qiu Yi, Shang Yu

Journal of China & Foreign Highway

A loose deposit slope is a special kind of rocky slope, whose material composition is characterized by nonlinearity, nonhomogeneity, and discontinuity, and China is a country with a high incidence of earthquakes, so the stability problem of loose deposit slope is particularly prominent. In this paper, the numerical simulation of the actual loose deposit slope MK0 + 455 of Ya’an–Kangding Expressway was carried out by using the particle flow code (PFC) to analyze its mechanical behavior and dynamic characteristics under seismic loading and reveal the progressive damage mechanism of the loose deposit slope. The results show that under seismic loading, …

Submission Of The Citizen Lab (Munk School Of Global Affairs, University Of Toronto) To The United Nations Working Group On Enforced Or Involuntary Disappearances, Siena Anstis, Ronald J. Deibert, Émilie Laflèche, Jonathon W. Penney

Commissioned Reports, Studies and Public Policy Documents

No abstract provided.

Hoxa9 Overexpression Contributes To Stem Cell Overpopulation That Drives Development And Growth Of Colorectal Cancer, Brian Osmond, Caroline O.B. Facey, Chi Zhang, Bruce M. Boman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

HOX proteins are transcription factors that regulate stem cell (SC) function, but their role in the SC origin of cancer is under-studied. Aberrant expression of HOX genes occurs in many cancer types. Our goal is to ascertain how retinoic acid (RA) signaling and the regulation of HOXA9 expression might play a role in the SC origin of human colorectal cancer (CRC). Previously, we reported that aldehyde dehydrogenase (ALDH) and other RA pathway components are co-expressed in colonic cancer SCs (CSCs) and that overpopulation of ALDH-positive CSCs occurs during colon tumorigenesis. Our hypothesis is RA signaling regulates HOXA9 expression, and dysregulated …

Pneumococcal Carriage In Infants Post-Pcv10 Introduction In Pakistan: Results From Serial Cross-Sectional Surveys, Shahira Shahid, Amala Khan, Muhammad Imran Nisar, Farah Khalid, Muhammad Farrukh Qazi, Sheraz Ahmed, Furqan Kabir, Aneeta Hotwani, Sahrish Muneer, Syed Asad Ali, Anita K. M. Zaidi, Fyezah Jehan

Department of Paediatrics and Child Health

The 10-valent pneumococcal vaccine was introduced in Pakistan's Expanded Program on Immunization (EPI) in 2013 as a 3 + 0 schedule without catchup. We conducted three annual cross-sectional surveys from 2014-2016 to measure vaccine-type (VT) carriage in infants from a rural part of Pakistan. Nasopharyngeal specimens were collected by random sampling of infants from two union councils of Matiari. Samples were then transported to the Infectious Disease Research Laboratory (IDRL) at the Aga Khan University within 6-8 h of collection. Serotypes were established using sequential multiplex PCR. Of the 665 children enrolled across three surveys, 547 were culture-positive for pneumococcus. …

Aspartyl Protease Inhibitors As Anti-Filarial Drugs, Liana Beld, Hyeim Jung, Christina A Bulman, Bruce A Rosa, Peter U Fischer, James W Janetka, Sara Lustigman, Judy A Sakanari, Makedonka Mitreva

2020-Current year OA Pubs

The current treatments for lymphatic filariasis and onchocerciasis do not effectively kill the adult parasitic nematodes, allowing these chronic and debilitating diseases to persist in millions of people. Thus, the discovery of new drugs with macrofilaricidal potential to treat these filarial diseases is critical. To facilitate this need, we first investigated the effects of three aspartyl protease inhibitors (APIs) that are FDA-approved as HIV antiretroviral drugs on the adult filarial nematode,

Anxiety Symptoms Among Extension Professionals' During The Covid-19 Pandemic With The Gad-2, Glenn D. Israel, Colleen E. Gariton, Harsha E. James

Journal of Rural Social Sciences

According to the National Institute of Mental Health, anxiety disorders are a common mental health disorder but often remain undetected and undertreated. During the COVID-19 pandemic, Extension professionals have worked hard to address emerging issues that communities face, possibly impacting the amount of anxiety they experience. This study determined the prevalence of anxiety symptoms among Extension professionals in the United States. Participants from 24 states completed a survey containing the Generalized Anxiety Disorder 2-item (GAD-2) screener. Almost one-quarter of Extension professionals had a GAD-2 score greater than three, an indicator of anxiety with a possibility of generalized anxiety disorder, which …

Preventive Behaviors Along The Rural-Urban Continuum In Utah During The Covid-19 Pandemic, Jessica D. Ulrich-Schad, Jennifer E. Givens, Mitchell Beacham

Journal of Rural Social Sciences

Rural individuals and places face major vulnerabilities in relation to the COVID-19 pandemic, yet how and why rural residents adopted preventive behaviors as a result is not well understood. Using cross-sectional data from an online panel survey of Utahans along the rural-urban continuum collected in June of 2020, we find that, overall, rural Utahans were less likely than their more urban counterparts to adopt preventive behaviors. Those who perceived less risk, knew someone sick with COVID-19, thought former President Trump was doing a good job handling the pandemic, had false optimism about the pandemic, had less formal education, and belonged …

Factors Explaining Variations In Covid-19 Deaths In Rural America, Don E. Albrecht

Journal of Rural Social Sciences

Early in the COVID-19 pandemic, case and death rates from the disease in rural counties were significantly lower than in urban counties. This pattern changed during the summer and fall of 2020, and by December, death rates in rural counties were higher than in urban counties. This article uses data from the U.S. Census Bureau and voting and COVID-19 data from The New York Times to explore factors related to the increase in COVID-19 deaths in rural counties in the United States. Further analysis is conducted to understand variations in death rates across different types of rural counties. Multivariate regression …

A Mixed Methods Evaluation Of Parents’ Perspectives On The Acceptability Of The S.A.F.E. Firearm Program, Katelin Hoskins, Christina Johnson, Molly Davis, Amy R. Pettit, Shari Barkin, Shari Jager-Hyman, Frederick Rivara, Maureen Walton, Courtney B. Wolk, Rinad S. Beidas

Journal of Applied Research on Children: Informing Policy for Children at Risk

Statement of Purpose:

Pediatric firearm access is a significant risk factor for unintentional injury and suicide. This study investigated parents’ perspectives on an adapted firearm safety program, S.A.F.E. Firearm, to ensure acceptability and optimize effectiveness prior to the launch of an upcoming hybrid effectiveness-implementation trial.

Methods/Approach:

We administered a cross-sectional survey with a convenience sample of U.S. parents to measure the acceptability of S.A.F.E. Firearm and other key variables (e.g., relationship with pediatrician) that may impact our implementation approach. The sample included 97 participants (52 firearm-owning and 45 non-owning) from across the country. We also conducted semi-structured interviews …

Guest Editor's Introduction, Katelyn Jetelina

Journal of Applied Research on Children: Informing Policy for Children at Risk

No abstract provided.

Functional Requirements For A Samd14-Capping Protein Complex In Stress Erythropoiesis, Suhita Ray, Linda Chee, Yichao Zhou, Meg A. Schaefer, Michael J. Naldrett, Sophie Alvarez, Nicholas T. Woods, Kyle J. Hewitt

Nebraska Center for Biotechnology: Faculty and Staff Publications

Acute anemia induces rapid expansion of erythroid precursors and accelerated differentiation to replenish erythrocytes. Paracrine signals—involving cooperation between stem cell factor (SCF)/Kit signaling and other signaling inputs—are required for the increased erythroid precursor activity in anemia. Our prior work revealed that the sterile alpha motif (SAM) domain 14 (Samd14) gene increases the regenerative capacity of the erythroid system in a mouse genetic model and promotes stress-dependent Kit signaling. However, the mechanism underlying Samd14’s role in stress erythropoiesis is unknown. We identified a protein-protein interaction between Samd14 and the α- and β-heterodimers of the F-actin capping protein (CP) complex. Knockdown of …

Peer Review, Robert Ferguson

CHED Talks

No abstract provided.

Cardiac Rehabilitation Adherence Rates In Elderly Patients Using A Mobile Application, Amanda Wilson

Yale School of Medicine Physician Associate Program Theses

Adherence to cardiac rehabilitation reduces cardiovascular disease mortality. Despite this, adherence rates remain suboptimal especially among older patients. Mobile applications are increasingly utilized to deliver virtual healthcare with similar health outcomes. However, no studies have determined whether cardiac rehabilitation delivered via mobile applications can increase adherence rates in elderly patients who may be limited by logistical barriers, such as difficulties with transportation. The aim of this study is to examine whether cardiac rehabilitation conducted via mobile application can increase adherence rates to cardiac rehabilitation in patients over 65 years old compared with traditional cardiac rehabilitation. We will conduct a randomized, …

Test Methods For Image-Based Information In Next-Generation Manufacturing, Henrique Oyama, Dominic Messina, Renee O'Neill, Samantha Cherney, Minhazur Rahman, Keshav Kasturi Rangan, Govanni Gjonaj, Helen Durand

Chemical Engineering and Materials Science Faculty Research Publications

Typical control designs in the process systems engineering literature have assumed that the primary sensing methodologies are traditional instruments such as thermocouples. Dig- italization is changing the landscape for manufacturing, and data-based sensing modalities (e.g., image-based sensing) are becoming of greater interest for plant control. These considerations require novel test/evaluation solutions. For example, process systems engineering researchers may wish to test image-based sensors in simulation. In this work, we provide preliminary thoughts on how image-based technologies might be evaluated via simulation for process systems.

Experimentation And Modeling Of Laser Radiation Scattering Through Carbon Fiber Reinforced Polymers, Steven P. Shepard

Engineering Ph.D. Theses

With the prevalence of carbon fiber reinforced polymers (CFRPs) in aerospace platforms, there is a need to better understand radiative heat transport through the material. A laboratory experiment was constructed and a computational zonal Monte Carlo (ZMC) model developed to quantify and understand the laser scattering properties of CFRPs. The ZMC model builds off of the zonal method (ZM)—developed by Hottel et al. and expanded by researchers such as Yuen et al.—by incorporating Monte Carlo techniques into the ZM. The ZMC method is superior in efficiency to the ZM and alternative ray tracing methods, which enables larger mediums of exchange …

Investigating Roles Of 2 Novel Eklf Targets Involved In Erythropoiesis, Rose M. Gott

ETD Archive

Erythrocytes are primarily comprised of the oxygen carrying protein hemoglobin. Genetic mutations causing defects in the proper synthesis of hemoglobin result in various anemias. It is during the last phases of terminal erythroid differentiation that hemoglobin levels rise, making it a focus for therapeutic research. Fetal hemoglobin is comprised of ⍺-globin and gamma globin, then after a change in gene expression called hemoglobin switching which takes place after birth, adult hemoglobin is comprised of ⍺-globin and beta globin. We investigated hemoglobin switching and erythroid terminal differentiation by focusing on the master erythroid transcription factor Erythroid Krüppel-like Factor (EKLF). Data led …

The Machine Upstairs, Jacob Friedfeld

College of Computing and Digital Media Dissertations

Immersive simulation design, broadly speaking, is a game design philosophy centered around player expression, emergent gameplay, and dynamic narrative. Contrary to what the phrase may imply simply by reading it, immersion in and of itself is not necessarily enough for a game to be classified as an “immersive sim” (or IMSIM for short). Many different types of games can utilize immersion to great effect, but immersive simulations require a level of flexibility and rule/system-based approaches beyond the scope of games that occupy similar genres.

The Machine Upstairs represents an exploration of the immersive simulation philosophy and an investigation into its …

An Analysis Of Groundwater Storage Loss In The Central Valley Using A Novel In Situ Method Compared To Grace-Derived Results, Michael David Stevens

Theses and Dissertations

Robust groundwater management is necessary to maintain long-term aquifer sustainability. Temporally and spatially inconsistent in situ data prevents robust groundwater resource evaluation. Data from the Gravity Recovery and Climate Experiment (GRACE) satellite mission has been used to evaluate long-term, large-scale groundwater trends. However, the spatial resolution of GRACE data presents challenges for groundwater management in medium-sized aquifers like the Central Valley of California (CV). Other researchers have utilized GRACEderived data to evaluate groundwater storage in the CV, but they often make corrections due to what is referred to as the "leakage effect." We demonstrate a method for imputing gaps in …

Intolerance Of Uncertainty, Sensory Processing, And Related Correlates In Autistic Children During The Covid-19 Pandemic, Mollie Bradley

Theses and Dissertations

The COVID-19 pandemic increased uncertainty and anxiety for most and was especially disruptive to autistic people and their families. Autistic children were particularly vulnerable due to their intolerance for increased uncertainty and disruption to their school and therapy support. This study aimed to investigate the effect that increased uncertainty had on autistic children, specifically their sensory behaviors and stress levels and on the stress levels of their primary caregivers. Parents and guardians of 47 autistic children completed an online survey consisting of questions investigating background and demographic information, their experiences during the first six months of the pandemic, information about …

Literacy Identity And Motherhood: Implications Of Hermans' Dialogical Self Theory, Chelsea J. Ames

Theses and Dissertations

This multiple case study shows how motherhood works with and against two women's literacy identities, as interpreted through the theoretical lens of Herman's Dialogical Self Theory. The evidence of this is shown in the tension between their roles as mothers and their personal roles as readers and writers. In many ways, taking on a reader or writer role meant to deny other roles for these women, showing the clash between efforts to consolidate multiple I-positions. While their meta-positions helped them recognize the discrepancies in their I-positions, there was little evidence of mediating third positions to negotiate their roles. This descriptive …

"Newstead And I Stand Or Fall Together": Memorial Ecology And Multispecies Agency In Byron's Early Poetry, Taylore Ann Wintch

Theses and Dissertations

Scholars studying memory, literary tourism, and Byron all note the cooperation between author and audience at work in memorials--be it in terms of speech and response, hospitality and reception, or memory and forgetting. None, however, address the environment at Newstead as an agentic being involved with Byron's memorial legacy. Byron acknowledged multispecies beings as important actors in his eventual legacy. Through some of his early poems, we see the land under and around Newstead Abbey, as well as its nonhuman life, exercising agency and affecting Byron's memory. I limit my analysis to Byron's early poetry partly to trace how a …

A Comparative Study On The Expository Writing Abilities Of Kindergarten Students With And Without Developmental Language Disorder, Kristine Michelle Dayley Andrus

Theses and Dissertations

State standards require kindergarten students to produce expository writing, but little research has been done regarding their abilities in this area. This study describes expository writing samples of 47 typically developing (TD) kindergarteners and 43 kindergarteners with developmental language disorder (DLD). The Expository Language Measures (ELM) Flow Chart and the Systematic Analysis of Language Transcripts (SALT) software were used to detail the language complexity and text structure features the children in the sample produced. When comparing TD and DLD children's expository written samples, no significant differences in the language and text structure measures were found. It is important to continue …

Investigation Of Material, Process, And Environmental Factors In Bubble Defect Formation For Labels Of Bottled Essential Oils, Joseph Lloyd Andrus

Theses and Dissertations

Labeling of consumer products is not only required by regulatory bodies for product identification, but it also serves as a symbol of product quality and prestige. Bubbles under the label are unsightly and impact customer satisfaction. Pressure Sensitive Adhesive (PSA) labels currently make up more than eighty percent of all labels in the market today, yet little research could be found addressing causes of bubbling in an industrial setting. A root cause analysis for bubble development included four aspects: label application, environmental conditions of shipping and storage, defects in glass bottle geometry, and oil contamination. The most significant findings from …

Chancellor's Cabinet Updates 2022-06, Karen Carey

Chancellor's Cabinet Updates

No abstract provided.

Humanitarismo Literario Y Migración Forzada: Un Estudio De Las Tierras Arrasadas De Emiliano Monge, Carlos Gardeazábal Bravo

Global Languages and Cultures Faculty Publications and Presentations

Las tierras arrasadas (2015) de Emiliano Monge se encuentra entre el creciente corpus de novelas y películas sobre los migrantes centroamericanos y los diferentes tipos de violencia que afrontan. Monge aborda en esta obra los efectos de la militarización en la política migratoria de México, impulsada por la guerra contra el narco que comenzó en 2006. Esta novela lleva a cabo un desmonte crítico del humanitarismo literario al tiempo que enfatiza la vulnerabilidad de los migrantes y su agencia. En tal sentido, se explora la forma en la que, en cuanto ficción posthumanitaria, la novela encarna las diferentes formas en …

International Water Quality: Global Patterns Of Water Pollutants And Pathogens, Leslie Lange

Theses and Dissertations

Water quality is an essential component of vibrant societies and ecosystems. For decades, researchers, managers, and policymakers around the world have struggled to accelerate societal progress while preserving and enhancing water quality and human health. This thesis consists of two studies that I hope will contribute to better understanding, policy, and management. In the first study, I evaluated spatial and temporal patterns in global water quality and their relationship to gross domestic product (GDP) per capita, as a metric of socioeconomic development status. Using global water quality datasets containing over 2.7 million observations, I tested the Environmental Kuznet Curve (EKC) …

Sars-Cov-2 Neuroinvasion, Inflammatory Neurodegeneration And Alzheimer's Disease, Yuhai Zhao, Walter J. Lukiw

School of Medicine Faculty Publications

No abstract provided.