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Astrophysics, Cosmology And Particle Phenomenology At The Energy Frontier, Jorge Fernandez Soriano

Dissertations, Theses, and Capstone Projects

This dissertation consists of two parts, treating significantly separated fields. Each part consists on several chapters, each treating a somewhat isolated topic from the rest. In each chapter, I present some of the work developed during my passage through the graduate program, which has mostly been published elsewhere.

Part I – Cosmic Rays and Particle Physics

• Chapter 1: In this chapter we present an introduction to the topic of cosmic ray physics, with an special focus on the so-called ultra high energy cosmic rays: their potential origins, effects during their propagation between their sources and Earth, the different techniques used …

The Role Of Mortality Salience And Social Identity In Police Officers And Students Reporting Misconduct, Anna M. Stenkamp

Dissertations, Theses, and Capstone Projects

Over the past several decades, high-profile police shootings, police brutality, and police misconduct have contributed to a decreased trust in policing in the United States. Beyond the severity and abuse of power, many of these incidents have also revealed that officers have covered up these incidents from the public. The refusal of police officers to both report misconduct or cover it up is well established and known as the “blue wall of silence.” However, no previous studies have examined the psychological processes behind this failure to report fellow officer misconduct. Two psychological theories that may explain this failure are Terror …

The T Visa Process And The Identification Of Victims Of Human Trafficking, Mandalena Prelashi

Dissertations, Theses, and Capstone Projects

The Trafficking Victims Protection Act of 2000 (TVPA) is a contemporary effort to combat human trafficking. In 2000, the Congress enacted the T Nonimmigrant Status (or T visa) in the effort to protect victims of trafficking and to enhance law enforcement’s ability to investigate and prevent these crimes in the U.S. This thesis explores from a legal and social point of view the obstacles, hurdles, and challenges that victims of human trafficking face, when applying for a T visa. I find that (1) victims assess their exploitation as wrong and immoral but not amounting to human trafficking, thus they are …

Novel Therapeutic Strategies For Alzheimer’S Disease: Prostaglandin D2 Signaling And Its Human Polymorphisms As Well As A Polypharmacological Approach, Charles H. Wallace

Dissertations, Theses, and Capstone Projects

Alzheimer’s disease (AD) is an age related neurodegenerative disease with pathology that includes amyloid plaques, neurofibrillary tangles and non-resolving neuroinflammation. Non-resolving neuroinflammation lasts the entire course of the disease and has deleterious effects and is often thought to accelerate AD pathology. Non-Steroidal Anti-inflammatory Drugs (NSAIDs) have commonly been used as therapeutics to treat pain, inflammation and vascular. NSAIDs work by altering the cyclooxygenase (COX) mediated biosynthesis of prostaglandins which are lipid mediators that have many physiological functions, for example nociception, inflammation and vasodilation. Epidemiological studies support the notion that NSAIDs could be used to treat AD. Yet, clinical trials using …

“The People Are Tired, And Just Want To Have Fun”: Mahraganat Music And The Struggle For Sonic Presence In Post-2013 Egypt, Mohammed Elfeky

Dissertations, Theses, and Capstone Projects

Building upon Asef Bayat’s notion of the “unintelligibility” of Egypt’s subaltern politics, this thesis investigates how mahraganat music is rendered “unintelligible/nonsense” by influential Egyptian cultural figures and is targeted for censorship. Mahraganat is a musical artform that arose from the lower-working classes neighborhoods in Egypt to become a dominant genre in the country. In 2020, the Egyptian Musicians Syndicate, headed by Hany Shakir, banned mahraganat artists from performing officially in Egypt. Before and after the ban, state media debated the genre's status; its detractors framed the music as nonsensical, “absurd”, “meaningless”, “vulgar”, and a “low-brow” dilution of Egyptian cultural production …

An Interdisciplinary Approach To The Epistemic Value Of Moral Ambiguity, Jordan Wylie

Dissertations, Theses, and Capstone Projects

Morality is a critical aspect of life––it influences how we think, design political and legal systems, who we connect with, our norms, and the types of stories we tell. Yet, even with the well documented influence of morality on many aspects of life, exactly what makes moral themes so fascinating remains elusive. This dissertation aims to introduce Moral Worldbuilding as a theory for understanding our epistemic drives toward morally ambiguous and morally bad content.

In Chapter I, we introduce the problem of moral badness, which is not well handled by extant moral literature. To combat this, we offer a new …

Deception Detection Across Domains, Languages And Modalities, Subhadarshi Panda

Dissertations, Theses, and Capstone Projects

With the increase of deception and misinformation especially in social media, it has become crucial to develop machine learning methods to automatically identify deception. In this dissertation, we identify key challenges underlying text-based deception detection in a cross-domain setting, where we do not have training data in the target domain. We analyze the differences between domains and as a result develop methods to improve cross-domain deception detection. We additionally develop approaches that take advantage of cross-lingual properties to support deception detection across languages. This involves the usage of either multilingual NLP models or translation models. Finally, to better understand multi-modal …

The Microscopical Evidence Traces Analysis Of Household Dust And Its Statistical Significance As A Definitive Identification Technique, Stephanie Polifroni

Dissertations, Theses, and Capstone Projects

Evidence found at crime scenes is used to assist in creating a link the suspect, the victim, and the scene. As stated by the Locard’s Principle, every contact leaves a trace, that evidence can be used to link together an investigation. Traces are collected in hopes that they can be identified and associated to an individual or individuals to help solve that particular crime. However, the strongest conclusion for evidence traces is an association to a source, and unless a physical match of some kind is found, an individualization cannot be established even when known sample is available. However, having …

The Campaign To End U.S. War-Making In Yemen: Strategies Of Congressional Advocacy, 2015–2020, Zachary Laub

Dissertations, Theses, and Capstone Projects

Civil society groups and a handful of lawmakers have pursued a robust campaign to end U.S. support for the Saudi-led war in Yemen in Congress. By framing the conflict as a war of Saudi aggression and pulling legislative levers that enabled them to force floor votes, advocates turned a niche issue into one that galvanized majorities in Congress and generated significant media coverage. Even when vetoes blocked their ability to enact binding war powers and arms transfer legislation, advocates nevertheless exerted political pressure that gave the president and the Saudi-led coalition alike impetus to moderate the war effort. This case …

Biochemical And Biophysical Characterization Of Replicative Helicase Loading By Vibrio Cholerae Dcia, Crystal Structure Of A Monoclonal Antibody Bound To A C-Terminal Fragment Of Ebna-1 From Epstein Barr Virus, Nicholas Gao

Dissertations, Theses, and Capstone Projects

DNA replication initiation is mediated by the binding of an initiator protein to genomic origins of replication to begin the process of loading replicative helicases onto the genome. The loading of the helicase requires the action of an accessory protein, named a “loader”. Studies on well-characterized loaders have outlined how the bacterial DnaB replicative helicase is loaded via mechanisms of “Ring-Breaking” by E. coli DnaC (EcDnaC)/protein P from bacteriophage lambda (LP) and “Ring-Making” by B. subtilis DnaI. Mounting evidence points to a recently discovered candidate loader, named DciA, that shows a more widespread distribution throughout bacteria than DnaC and DnaI …

Examining The Linguistic Ideology "Throaty Sounds Are Bad For Performers": The History Of Negative Attitudes Towards Glottal Stops And Laryngealization In English, Dayle M. Towarnicky

Dissertations, Theses, and Capstone Projects

This thesis analyzes explicit metadiscourse (Johnstone et al 2006) on throaty sounds, primarily focused on glottal segments and non-modal constricted voice quality in English. Authors contributing to this metadiscourse are argued to be an offshoot of the speech chain network which valorized and circulated the English accent known as RP or Received Pronunciation, studied by Agha (2003). The evaluated texts center on English-speaking elocution, singing training, voice, speech, and voice care. The analysis shows glottal and guttural articulations are framed negatively and often discouraged by appeals to both health and aesthetics. Many authors in this performance speech chain network …

Magnetic Field Effects On The Physics Of Neutron Stars, Aric A. Hackebill

Dissertations, Theses, and Capstone Projects

In the context of neutron stars (NS), dense-magnetized quark and hadron models have been well studied under the assumption that the system's pressures are isotropic. However, the pressures determined from semi-classical statistical averaging of the energy momentum tensor in the presence of a uniform background magnetic field are anisotropic with different pressures arising along and perpendicular to the magnetic field direction. Since large magnetic fields are expected to be present in the interior of NS, it is important to understand the roll the pressure anisotropy plays. While considering the pressure anisotropy, we revisit some important calculations in NS physics.

We …

Del Ornitorrinco A La Radio Ambulante: La Nueva Crónica Latinoamericana En La Era Neoliberal, Ulises Gonzales

Dissertations, Theses, and Capstone Projects

This dissertation explores the presence of neoliberal hegemonic imaginaries in narrative journalism written in Latin America between 1995 and 2021.

There are strong connections between a period of decline in the readership of some of the authors of the so-called “Latin American Boom,” the penetration of neoliberal economic policies in the region (with the privatization of State companies and the expansion of the telecommunications industry), and the renewed interest in non-fiction writing published by a number of print publications in the region during the last decade of the 20th Century and the beginning of the 21st Century, as in magazines …

Women And Ventriloquism In Early Modern English Drama, Ja Young Jeon

Dissertations, Theses, and Capstone Projects

Bringing together feminist and theater-centered readings, this dissertation examines the status of female vessels that foreign voices inhabit and animate in early modern drama, arguing that the Greek model of ventriloquism represented by the Pythia exerted a powerful influence on the period’s ideas about women’s speech. In feminist work on ventriloquism, despite highlighting theatrical performance’s dependence on citationality, ventriloquism has been largely understood as an analogue for exploring male poets’ authorial power to appropriate women’s voices. In these readings, the term ‘ventriloquist’ is mainly identified with the person who throws his voice into human or nonhuman objects, reminding us of …

Visible Light Photocatalysis Of Organic Reactions In H2o, Sankarsan Biswas

Dissertations, Theses, and Capstone Projects

Visible-light photocatalysis in H₂O provides an attractive, green alternative to typical organic synthesis, which often involves toxic solvents, metal catalysts, and large energy demands. Hence, there is a growing need for an efficient photocatalytic methods that use either aqueous media as a solvent or can proceed solvent-free. However, commercially available photocatalysts do not work well for aqueous photocatalysis. Supramolecular systems in particular have been explored recently to address these issues associated with aqueous photocatalysis. Chapter 1 will review recent advances in aqueous supramolecular photocatalysis with examples of different supramolecular systems and how they have addressed some of the …

Generation Of Mycobacterium Smegmatis Model Systems For Testing Inhibitors Of The Mycobactin Siderophore Of Mycobacterium Tuberculosis, Gabrielle A. Germain

Dissertations, Theses, and Capstone Projects

Mycobacterium tuberculosis (Mtb) is the pathogenic bacterium causative of tuberculosis. According to the 2021 World Health Organization (WHO) Global Tuberculosis (TB) Report, there were approximately 5.8 million TB cases in 2020, and 1.3 million TB deaths among HIV negative people in that year. The rise of multi-drug resistant Mtb strains has increased the need for more potent microbials against this pathogen. Biosynthesis of iron scavenging molecules, known as siderophores (e.g., mycobactin and carboxymycobactin), has been identified as a potential drug target candidate since iron acquisition has been directly linked to the survival and virulence of Mtb. Salicyl-AMS (Sal-AMS) is …

Audiovisual Afterlives: The Soundtrack Of Liberal Nostalgia, Max W. Kaplan

Dissertations, Theses, and Capstone Projects

Following the 2016 American Presidential election, celebrity endorsements proved to be a more narrow gauge of public opinion than ever. The symbolic alignment with popular musicians, which had long abetted the Democratic Party’s standing with youth and particular identity groups, seemed only to reaffirm the party’s establishment status, drawing disavowal in a wave of anti-establishment sentiment on both the left and right. ‘Retromania,’ a term first coined by Simon Reynolds in 2010, can be tracked conceptually from the nostalgic inclinations of twenty-first century popular culture to the ideological sphere, where nostalgic, essentialized constructions of community, identity, and progress have coalesced …

Heritage Repair: Revisiting Familial And Collective Histories In Filiation Narratives By Dalila Kerchouche, Colombe Schneck And Martine Storti, Rebecca R. Raitses

Dissertations, Theses, and Capstone Projects

This thesis offers a critical reading of three French narratives: Dalila Kerchouche’s Mon père, ce harki (2003), Colombe Schneck’s Les guerres de mon père (2018), and Martine Storti’s L’arrivée de mon père en France (2008). These works combine representations of familial history with the explorations of personal and collective traumas or repression. The study addresses the following dimensions of the texts: 1) The catalyst of intergenerational silence behind these and many other similar works; 2) The textual interplay between storytelling and material evidence; 3) The ways in which the authors combine narratives of familial hardships on one hand, and of …

Tell Me A Story: The Normative Power Of Storytelling, Zoe Cunliffe

Dissertations, Theses, and Capstone Projects

Few would dispute that stories are powerful: they have the capacity to inform, to persuade, and to engage our imaginations and sympathies. However, the contemporary philosophical literature on stories focuses exclusively on the functions of narrative stories, and in particular on the role that novels can serve in cultivating our moral and political competencies. I argue that this narrow focus is theoretically pernicious in two ways. First, it leads to an unfortunate myopia regarding the value of non-narrative storytelling practices. Second, it results in analysis that is disproportionately likely to exclude forms of storytelling that originate in marginalized groups. My …

Mrnip Interacts With Sex Body Chromatin To Support Meiotic Progression, Spermatogenesis, And Male Fertility In Mice, Samina Kazi, Julio M Castañeda, Audrey Savolainen, Yiding Xu, Ning Liu, Huanyu Qiao, Ramiro Ramirez-Solis, Kaori Nozawa, Zhifeng Yu, Martin M Matzuk, Renata Prunskaite-Hyyryläinen

Faculty, Staff and Students Publications

Meiosis has a principal role in sexual reproduction to generate haploid gametes in both sexes. During meiosis, the cell nucleus hosts a dynamic environment where some genes are transcriptionally activated, and some are inactivated at the same time. This becomes possible through subnuclear compartmentalization. The sex body, sequestering X and Y chromosomes during male meiosis and creating an environment for the meiotic sex chromosome inactivation (MSCI) is one of the best known and studied subnuclear compartments. Herein, we show that MRNIP forms droplet‐like accumulations that fuse together to create a distinct subnuclear compartment that partially overlaps with the sex body …

Quality Of Life, Illness Perceptions, And Parental Lived Experiences In Tango2-Related Metabolic Encephalopathy And Arrhythmias, Chaya N Murali, Seema R Lalani, Mahshid S Azamian, Christina Y Miyake, Hadley Stevens Smith

Faculty, Staff and Students Publications

TANGO2 disorder is a rare genetic disease with multi-system effects that causes episodic crises. Quality of life and psychosocial effects of this rare disease have not previously been studied. To examine health-related quality of life (HRQoL), illness perceptions, and lived experience, we surveyed 16 children and 31 parents of children with TANGO2 disorder identified via a disease-specific social media group and research foundation email distribution list. We assessed HRQoL by parent proxy-report and child self-report using the Pediatric Quality of Life Inventory (PedsQL™). Parental perceptions of their child's condition were assessed using the revised illness perceptions questionnaire adapted for TANGO2 …

Big Three Power, And Why It Matters, Lucian Bebchuk, Scott Hirst

Faculty Scholarship

This Article focuses on the power and corporate governance significance of the three largest index fund managers commonly referred to collectively as the “Big Three.” We present current evidence on the substantial voting power of the Big Three and explain why it is likely to persist and, indeed, further grow. We show that, due to their voting power, the Big Three have considerable influence on corporate outcomes through both what they do and what they fail to do. We also discuss the Big Three’s undesirable incentives both to underinvest in stewardship and to be excessively deferential to corporate managers.

In …

Critical Care Nurse Burnout, Moral Distress, And Mental Health During The Covid-19 Pandemic: A United States Survey, Jill L. Guttormson, Kelly Calkins, Natalie S. Mcandrew, Jacklynn M. Fitzgerald, Holly Lynn Losurdo, Danielle Loonsfoot

Psychology Faculty Research and Publications

Background

The COVID-19 pandemic has and will continue to have a tremendous influence on intensive care unit (ICU) nurses’ mental health.

Objectives

The purpose of this study was to describe the impact of COVID-19 on nurse moral distress, burnout, and mental health.

Methods

Between October 2020 and January 2021 this descriptive study recruited a national sample of nurses who worked in the ICU during the COVID-19 pandemic through American Association of Critical Care Nurses newsletters and social media.

Results

A total of 488 survey responses were received from critical care nurses working in the U.S. during the COVID pandemic. Over …

Pgc-1Α Overexpression Is Not Sufficient To Mitigate Cancer Cachexia In Either Male Or Female Mice, Francielly Morena Da Silva, Megan Rosa-Caldwell, Eleanor R. Schrems, Lauren Martinez, Madeline G. Amos, Seongkyun Lim, Ana Regina Cabrera, Jacob L. Brown, Tyrone A. Washington, Nicholas P. Greene

Health, Human Performance and Recreation Faculty Publications and Presentations

Cancer cachexia (CC) accounts for 20%–40% of cancer-related deaths. Mitochondrial aberrations have been shown to precede muscle atrophy in different atrophy models, including cancer. Therefore, this study investigated potential protection from the cachectic phenotype through overexpression of peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1α). First, to establish potential of mitochondria-based approaches we showed that the mitochondrial antioxidant MitoTEMPO (MitoT) attenuates myotube atrophy induced by Lewis lung carcinoma (LLC) cell conditioned media. Next, cachexia was induced in muscle-specific PGC-1α overexpressing (MCK-PCG1α) or wildtype (WT) littermate mice by LLC implantation. MCK-PCG1α did not protect LLC-induced muscle mass loss. In plantaris, Atrogin mRNA …

Will Anti-Vaccine Activism In The Usa Reverse Global Goals?, Peter J Hotez

Center for Medical Ethics and Health Policy Staff Publications

In the time of the COVID-19 pandemic, anti-vaccine activism in the USA accelerated, amplified and formed an alliance with political groups and even extremists. An organized, well-funded and empowered anti-science movement now threatens to spill over and threaten all childhood immunizations in the USA and globally.

Jihadist Attacks In The West: 2014-2022, Lorenzo Vidino, Francesco Marone, Program On Extremism, George Washington University, National Counterterrorism Innovation, Technology, And Education Center

Reports, Projects, and Research

Jihadism in the West has a roughly four-decade long history. Its first, embryonal presence dates back to the 1980s, when scattered groups of Western-based volunteers traveled to Afghanistan to fight against the Soviet Union. Around the same time, a few Middle Eastern and North African jihadists fleeing their countries of origin received asylum in various Western countries. Since then, both Europe and North America have steadily been home to pockets of sympathizers of jihadist ideology. These pockets have historically been extremely heterogeneous and have undergone huge changes over time. They have always varied in size and complexity; while some are …

Contemporary Violent Extremism And The Black Hebrew Israelite Movement, Program On Extremism, The George Washington University, National Counterterrorism Innovation, Technology, And Education Center

Reports, Projects, and Research

This report evaluates violent extremism inspired by or connected to the Black Hebrew Israelite (BHI) movement. Black Hebrew Israelites ascribe to the idea that modern-day African Americans are the descendants of the Israelites in the Old Testament of the Bible. However, an extremist fringe within the movement takes this idea one step further, arguing that white Europeans are the descendants of Satan and that white Jews are impostors. Situating the role of extremist interpretations of BHI ideology within domestic violent extremist incidents during the past several years, this report finds:

● Like other domestic violent extremist movements in the contemporary …

Applications Of Temperature Transient Analysis For Reservoir Surveillance, Refaat Galal Aboelfotoh Hashish

LSU Doctoral Dissertations

Reservoir monitoring is a key factor in the management of oil and gas resources. With the recent developments of permanent downhole temperature monitoring tools such as Fiber-Optic Distributed Temperature Sensing (FO-DTS), temperature transient analysis has evolved as a new alternative for reservoir monitoring. In this work, different techniques of temperature data analysis are presented for monitoring and characterization of hydrocarbon and geologic carbon storage (GCS) reservoirs. The objective of this study is to present new approaches that enable monitoring injection profile through vertical and horizontal injection wells using temperature warmback analysis. Application of temperature warmback analysis is also extended for …

Shelter Staff Perceptions Of Physicians Seeking Services For Intimate Partner Violence, Gabriela Bagnara

Loma Linda University Electronic Theses, Dissertations & Projects

Research indicates there are a significant number of instances of intimate partner violence (IPV) in the United States, with current prevalence rates impacted by a substantial amount of underreporting due to stigma, difficulty disclosing, and complex love and fear of abusive partners (Breiding et al., 2014; Ellsberg & Heise, 2005; Overstreet & Quinn, 2013). A large body of IPV research exists more generally, but there is little understanding about the help-seeking behaviors of high socioeconomic status (SES) individuals within IPV shelter systems. While several studies have demonstrated the equal impact of abuse across demographic contexts (Satyen, Rogic, and Supol, 2018; …

Coercive Control And Trauma-Coerced Attachment In Commercial Sexual Exploitation: A Mixed-Method Examination, Kendra Doychak

Dissertations, Theses, and Capstone Projects

Commercial sexual exploitation (i.e., sex trafficking) can lead to myriad negative consequences for its victims, including exposure to coercive control and the development of trauma-coerced attachments. Scholars have offered theoretical conceptualizations of the relation between coercive environments and traumatic attachments, but this relationship is rarely empirically examined. The current study used data from 68 semi-structured interviews with former victims of sex trafficking to first, formally identify coercive control and second, empirically classify trauma-coerced attachment in this population. Mixed-method analysis were used to identify associations between coercive control and TCA in order to better explain how this abuse dynamic leads to …