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Mitigating The Harm Of Public Mass Shooting Incidents Through Situational Crime Prevention, Emily Greene-Colozzi Sep 2022

Mitigating The Harm Of Public Mass Shooting Incidents Through Situational Crime Prevention, Emily Greene-Colozzi

Dissertations, Theses, and Capstone Projects

This dissertation used environmental theoretical frameworks to understand how public mass shooting incidents are impacted by aspects of the crime situation and opportunity. Predatory, public shootings perpetrated by individuals with evidence of mass intent were examined in the United States between 1966 and 2019. This project progressed in several distinct steps with discrete aims: (1) establish an open source database of public mass shooting incidents meeting definitional criteria; (2) perform statistical analysis, including latent class analysis, regression modeling, and structural equational modeling to assess research questions; and (3) perform comparative case studies and crime script analysis to assess situational crime …


Learning Beyond Measure: Critical Numeracy And Resistance To Racial Capitalism, Atasi Das Sep 2022

Learning Beyond Measure: Critical Numeracy And Resistance To Racial Capitalism, Atasi Das

Dissertations, Theses, and Capstone Projects

In this three-article dissertation, I connect with and expand from learning theories and mathematics and numeracy practices to reimagine numeracy as a potential tool towards liberation and human emancipation. Developing a framework and activity of critical numeracy, I explore the ways numbers and static categories have been used to “objectively” create, reproduce, and reify hierarchies within historical contexts and power relations. The core of this work examines, what do numbers and numeracy mean for us? Who are “the us” we can organize for? And for what purpose can and should we utilize, teach, and learn with numbers in and beyond …


Sensitized Photooxidation Of Prenylated Compounds: Mechanisms Of Downstream Dark Effects And Phototoxicity Priming, Shakeela Jabeen Sep 2022

Sensitized Photooxidation Of Prenylated Compounds: Mechanisms Of Downstream Dark Effects And Phototoxicity Priming, Shakeela Jabeen

Dissertations, Theses, and Capstone Projects

This thesis consists of four chapters as detailed below.

Chapter 1 discusses a singlet oxygen priming mechanism. Airborne singlet oxygen derived from photosensitization of triplet dioxygen is shown to react with an alkene surfactant (8-methylnon-7-ene-1 sulfonate) leading to ‘ene’ hydroperoxides that in the dark inactivate planktonic E. coli. The ‘ene’ hydroperoxide photoproducts are not toxic on their own, but they become toxic after the bacteria are pretreated with singlet oxygen. The total quenching rate constant (kT) of singlet oxygen of the alkene surfactant was measured to be 1.1 × 106 M−1 s− …


Nutrient Dynamics And Ecosystem Development Of Urban Forests, Gisselle A. Mejía Sep 2022

Nutrient Dynamics And Ecosystem Development Of Urban Forests, Gisselle A. Mejía

Dissertations, Theses, and Capstone Projects

Urban growth and expansion are a major component of global environmental change, with impacts on climate, air and water quality, biodiversity, and human well-being. Forests embedded in urban landscapes are critical in mitigating these impacts at local, regional, and continental scales. However, assessing urban forests is difficult because cities are heterogenous in physical, chemical, biological, and social dimensions. This heterogeneity has constrained how urban forests are defined, and therefore, how they are studied. The objective of this dissertation is to determine how these biophysical and social factors drive ecological processes in urban forests and will address three outstanding challenges in …


Isolation And Characterization Of Fluorescent Proteins And Small Molecules From Marine Vertebrates, Sara Rose Krivoshik Sep 2022

Isolation And Characterization Of Fluorescent Proteins And Small Molecules From Marine Vertebrates, Sara Rose Krivoshik

Dissertations, Theses, and Capstone Projects

Fluorescence is a phenomenon in which a wavelength of light excites a fluorophore and then emits light at a higher, longer wavelength. This occurs throughout the biological world, in both the terrestrial and marine realms. Encompassing a diverse set of mechanisms from small molecules to large protein complexes; fluorescence has been used as a biological tool with a wide range of applications to study molecular and cellular biology for decades. This dissertation looks to identify and characterize novel fluorescent proteins and small molecules to allow for more efficient translation in developing new biotechnologies. Using a combination of RNA-Seq, Mass-Spec, protein …


Conformation Of The U12-U6atac Snrna Complex Of The Minor Spliceosome And Binding By Ntc-Related Protein Rbm22, Joanna Ciavarella Sep 2022

Conformation Of The U12-U6atac Snrna Complex Of The Minor Spliceosome And Binding By Ntc-Related Protein Rbm22, Joanna Ciavarella

Dissertations, Theses, and Capstone Projects

Splicing of precursor messenger (pre-m)RNA is a critical process in eukaryotes in which the non-coding regions, called introns, are removed and coding regions, or exons, are ligated to form a mature mRNA. This process is catalyzed by the spliceosome, a multi-mega Dalton ribonucleoprotein complex assembled from five small nuclear ribonucleoproteins (snRNP) in the form of small nuclear (sn)RNA-protein complexes (U1, U2, U4, U5 and U6) and >100 proteins. snRNA components catalyze the two transesterification reactions while proteins perform critical roles in assembly and rearrangement. U2 and U6 snRNAs are the only snRNAs directly implicated in catalyzing the splicing of pre-mRNA. …


The Cultural Battle Against The Dollar: Struggles Over Hoarding And Democracy In The Twilight Of Argentina's Soy Boom, Charles Dolph Sep 2022

The Cultural Battle Against The Dollar: Struggles Over Hoarding And Democracy In The Twilight Of Argentina's Soy Boom, Charles Dolph

Dissertations, Theses, and Capstone Projects

Argentina’s economy has undergone a profound transformation over recent decades from beef and wheat to soybeans and derivative products as the country’s main export commodity and source of foreign exchange. The dissertation traces this shift against the historical backdrop of the country’s peculiar class, territorial, and state formations as the only Latin American nation where agrarian reform has been altogether absent. This perspective on Argentina’s experience with the so-called Green Revolution in agriculture reveals it as an expansive project in which the U.S. dollar figures as an instrument of pacification and acquiescence to agribusiness hegemony. Amid an early twenty-first century …


Engineering Rare-Earth Based Color Centers In Wide Bandgap Semiconductors For Quantum And Nanoscale Applications, Gabriel I. López-Morales Sep 2022

Engineering Rare-Earth Based Color Centers In Wide Bandgap Semiconductors For Quantum And Nanoscale Applications, Gabriel I. López-Morales

Dissertations, Theses, and Capstone Projects

For many years, atomic point-defects have been readily used to tune the bulk properties of solid-state crystalline materials, for instance, through the inclusion of elemental impurities (doping) during growth, or post-processing treatments such as ion bombardment or high-energy irradiation. Such atomic point-defects introduce local ‘incompatible’ chemical interactions with the periodic atomic arrangement that makes up the crystal, resulting for example in localized electronic states due to dangling bonds or excess of electrons. When present in sufficient concentrations, the defects interact collectively to alter the overall bulk properties of the host material. In the low concentration limit, however, point-defects can serve …


From Perfect Victims To Collateral Damage: How Nigerian Women Are Implicated In And Impacted By Contemporary French Anti-Trafficking Policies And Discourse, Oladunni Patricia Oduyemi Sep 2022

From Perfect Victims To Collateral Damage: How Nigerian Women Are Implicated In And Impacted By Contemporary French Anti-Trafficking Policies And Discourse, Oladunni Patricia Oduyemi

Dissertations, Theses, and Capstone Projects

Although the Nordic Model has been embraced by the international anti-trafficking movement, recent studies, and closer examinations of France’s approach to the issue of sex trafficking reveal a strong anti-migrant and anti-sex work bias. In this thesis, I use studies of the impacts of France’s 2016 anti-trafficking bill on migrant sex workers, feminist critiques of neo-abolitionism and the Nordic Model, and examples of France’s hypocritical anti-migrant position, to explore how Nigerian women are harmed by the contemporary French fight against sex trafficking. The pervasive influence of anti-sex work radical feminism on anti-trafficking protocols which define the sex industry as analogous …


Understanding Parental Engagement At The Nexus Of Race, Class, Gender, And Sexual Orientation: An Examination Through Anti-Black White Settler Colonialism, Alyssa P. Lyons Sep 2022

Understanding Parental Engagement At The Nexus Of Race, Class, Gender, And Sexual Orientation: An Examination Through Anti-Black White Settler Colonialism, Alyssa P. Lyons

Dissertations, Theses, and Capstone Projects

In the great scramble to remedy the inequalities of American education, the term “parental engagement” has remained a stubborn fixture in political, educational, and public discourse since the 1960s. Parental engagement has been offered as a possible mitigation tool in the fight for educational justice. This has led to ample social science research exploring the significance and impact of parental engagement on a host of educational outcomes. With much of the sociological theorizing of education stuck in the 1960s, scholars need new ways of theorizing to better understand the role of parental engagement in not alleviating educational inequalities—but in maintaining …


Purity, Exclusion, And Political Order In Colombia, Osha Smith-Gittelman Sep 2022

Purity, Exclusion, And Political Order In Colombia, Osha Smith-Gittelman

Dissertations, Theses, and Capstone Projects

This dissertation examines the relationship between purity and order, and the ways this relationship informs and reproduces exclusionary forms of governance. The starting point for this analysis is the puzzling use of the language of limpieza social [social cleansing] as a justification for violence in Latin America. Such language is publicly disseminated by vigilantes, criminal organizations, paramilitaries, and other extralegal armed actors as a frame for violence against those presumed to be criminals, drug users, sex workers, unhoused, LGBTQ, or mentally ill. Much has been written on criminal and political violence in the region, but there has been less emphasis …


La Literatura Al Gobierno: José De La Riva-Agüero Y Luis Alberto Sánchez En La Modernización Civilista (1905–1928), Alexis V. Iparraguirre Castro Sep 2022

La Literatura Al Gobierno: José De La Riva-Agüero Y Luis Alberto Sánchez En La Modernización Civilista (1905–1928), Alexis V. Iparraguirre Castro

Dissertations, Theses, and Capstone Projects

My dissertation examines Jose de la Riva-Aguero and Luis Alberto Sanchez’s studies on Peruvian literature at the turn of the 20th century. Their texts not only established the characteristics of Peruvian literature and the methods required for their study but also argued that teaching it at the university level had practical implications for national life. This is why Riva-Agüero’s El carácter de la literatura en el Perú independiente (1905) and Sanchez’s La literatura peruana (1928-1929) sought to establish a social psychology that would be able to offer a diagnostic of the nation. In the case of Riva-Agüero, this was geared …


Graphic Novels In The Foreign Language Classroom: Teaching Central American History In The Target Language, Vanessa Elizabeth Guzmán Sep 2022

Graphic Novels In The Foreign Language Classroom: Teaching Central American History In The Target Language, Vanessa Elizabeth Guzmán

Dissertations, Theses, and Capstone Projects

Graphic novels are becoming increasingly helpful in the foreign language classroom. As a Spanish teacher in the Bronx, I have introduced numerous graphic novels into my lessons. Some graphic novels include familiar characters and are presented in a translated work, while others are graphic novels that were originally printed in Spanish. I have witnessed the advantages of using graphic novels in my classroom as the illustrations provide my readers with context clues to better understand the reading. I have also found some graphic novels that focus on historical events in Latin America but these works were either written entirely in …


The Cognitive, Behavioral, Affective, And Physiological Components Of Social Cognition In Esports And Education, Daisy Reyes Sep 2022

The Cognitive, Behavioral, Affective, And Physiological Components Of Social Cognition In Esports And Education, Daisy Reyes

Dissertations, Theses, and Capstone Projects

Prior research has shown that collaborative learning, or groups of two or more individuals working together towards a shared outcome, and Computer-Supported Collaborative learning has the potential to positively impact learning outcomes. This study aims to add to existing literature on collaborative learning by looking at how novices and experts learn and perform in esports (electronic sports) teams, or highly coordinated digital teams that often compete in stressful environments. Based on Carron’s Model of Cohesion in Sports Teams and Hanin’s Model of Individualized Zones of Optimal Functioning (IZOF), the current study looks at the relationship between cohesion (i.e., task and …


Assembling The African City: Music Streets And Associational Life In Dakar's Médina, Brendan Kibbee Sep 2022

Assembling The African City: Music Streets And Associational Life In Dakar's Médina, Brendan Kibbee

Dissertations, Theses, and Capstone Projects

What can you understand about a city through its music? Most days and nights in Dakar’s Médina­­––a crowded quartier populaire adjacent to the city’s central administrative zone–– streetscapes are transformed by musical assemblies, including life cycle ceremonies and events produced by the neighborhood’s robust array of civic and religious associations. This dissertation examines how the confluence of music, public spaces (streets), and associational life shapes the possibilities of urban living in the contemporary African city. The musical assemblies that fill the neighborhood, I argue, spatialize social life in the city, organizing people’s movements, exposing them to a common sense-world, and …


Festivali11: The Long Sixties And Women In Communist Albania, Manjola Shehu Sep 2022

Festivali11: The Long Sixties And Women In Communist Albania, Manjola Shehu

Dissertations, Theses, and Capstone Projects

Festivali11 is a digital project that aims to highlight the experiences of Albanian women during the communist period by collecting, digitizing and publishing oral histories for an Albanian and international audience. The heart of the project, which is hosted at www.festivali11.com, is a collection of educational materials built from two digitized interviews with an Albanian woman that describe her experiences during this period.

The project aims to showcase the potential of oral history in centralizing the experience of marginalized people in historical narratives and to provide contextualized, multimedia information and resources about this topic to an international public and facilitate …


Homotextualité Réaliste: Cryptosexualité Et Subculture Homosexuelle Masculine Chez Balzac, Stendhal, Flaubert, Vincent Sallé Sep 2022

Homotextualité Réaliste: Cryptosexualité Et Subculture Homosexuelle Masculine Chez Balzac, Stendhal, Flaubert, Vincent Sallé

Dissertations, Theses, and Capstone Projects

Cette thèse étudie les romans du canon réaliste français, en particulier Le Rouge et le noir et L’Éducation sentimentale, sous l’angle d’une textualité parallèle ancrée dans la langue érotique et les pratiques et les lieux de la subculture pédéraste. Principalement étudiée jusqu’ici dans des corpus identifiés comme érotiques ou dans des passages représentant l’homosexualité, cette homotextualité est ici inscrite dans la diégèse hétérosexuelle qu’elle permet de relire de manière située et historicisée.

La période de 1830 à 1870 est perçue par l’histoire et la littérature comme un hiatus sur le thème de l’homosexualité, pris entre son histoire moderne à …


The Value Of Nfts, Angelina Tham Sep 2022

The Value Of Nfts, Angelina Tham

Dissertations, Theses, and Capstone Projects

Non-fungible token stories have flooded the media since the beginning of the COVID-19 pandemic. NFTs have changed the public’s views on art, finances, and the self. The emergence of Web 3 redefined ways of self expression with the help of NFTs. What are NFTs, how are they valuable, and how will they shape the future of digital art? The data visualization for this project indicates that the most popular type of crypto art is in the style of a profile picture. The discussion suggests that NFTs are in their infancy and there will be more to come from digital art, …


Mechanism Of Tau Propagation: Putative Therapeutic Approaches, Viktoriya Morozova Sep 2022

Mechanism Of Tau Propagation: Putative Therapeutic Approaches, Viktoriya Morozova

Dissertations, Theses, and Capstone Projects

One of the characteristics of Alzheimer’s disease and associated tauopathies is the accumulation and aggregation of hyperphosphorylated tau protein. The biological activity of tau is to bind to tubulin and promote its assembly into microtubules with subsequent stabilization of the latter. When tau gets hyperphosphorylated it cannot bind to tubulin and carry on its function, instead, it binds to normal tau and sequesters it from microtubules leading to disruption of microtubular assembly and ultimately to the death of neurons. Our lab had previously shown that tau phosphorylation sites 199, 212, 231, and 262, combined with the FTDP-17 mutation R406W (Pathological …


Operation Lone Star: The Spectacle Of Immigration Federalism, Danielle Puretz Sep 2022

Operation Lone Star: The Spectacle Of Immigration Federalism, Danielle Puretz

Dissertations, Theses, and Capstone Projects

Texas Governor Greg Abbott launched Operation Lone Star in March 2021 to respond to the “crisis” at the United States/Mexico border. While in the US immigration is usually thought of as a federal responsibility, different states have worked to expand their capacity to welcome or exclude immigrants. Operation Lone Star is an example of how one state is working to restrict immigration to the US and build notoriety for its republican governor. Drawing on press releases, executive orders, news articles, opinion pieces, and other sources I highlight the performative politics within this initiative. Operation Lone Star is an example of …


Destination Icaic: Cosmopolitan Intellectuals, Documentary Film And The Image Of The Cuban 1960s, Gabriel Arce-Riocabo Rollins Sep 2022

Destination Icaic: Cosmopolitan Intellectuals, Documentary Film And The Image Of The Cuban 1960s, Gabriel Arce-Riocabo Rollins

Dissertations, Theses, and Capstone Projects

This study analyzes the interaction between foreign intellectuals and ICAIC (Instituto cubano de artes e industrias cinematográficas) in shaping the image of Cuba in the 1960s. I make the case that the idea of Revolution was a product of cosmopolitan intellectual engagement and that in this process documentary film was a privileged medium. By tracing the development of normative stories of commitment, cosmopolitanism, and aesthetic experimentation embodied both in written texts and travel essay films, I argue that such circulation destabilizes fixed ideas of Cuban, Revolutionary or Intellectual. The archive of Danish filmmaker and ICAIC collaborator Theodor Christensen as well …


Virtual Reality Supplement To The Peers Social Skills Intervention For Adolescents With Asd, Kevin Ambrose Sep 2022

Virtual Reality Supplement To The Peers Social Skills Intervention For Adolescents With Asd, Kevin Ambrose

Dissertations, Theses, and Capstone Projects

The purpose of this study was to replicate findings of the Program for the Education and Enrichment of Relation Skills (PEERS) parent-assisted social skills training program for a diverse group of adolescents with historical autism spectrum disorder (ASD) diagnoses in an urban locality. Additionally, this study sought to pilot a 3D multi-user virtual environment for adolescent participants and an online learning community for parent coaches; both hypothesized to reinforce the social skills curriculum. A randomized controlled trial of PEERS was completed with 12 adolescents diagnosed with ASD with some participation from their caregivers. Results show that participants who received the …


“The Formation Of A Personality”: Shostakovich’S Fifth Symphony And The Politics Of Its Hermeneutic Reception, Ki Ki Leung Sep 2022

“The Formation Of A Personality”: Shostakovich’S Fifth Symphony And The Politics Of Its Hermeneutic Reception, Ki Ki Leung

Dissertations, Theses, and Capstone Projects

This dissertation provides a new perspective on Shostakovich’s widely discussed Fifth Symphony by scrutinizing the formation of its Bildungsroman narrative and its transformation from a prototype of Soviet symphonism into an anti-Soviet statement. I begin by reaching back to 1930s Soviet Russia, when Soviet symphonism was formulated to comply with the official ideology of socialist realism. Building on Paul Bekker’s gemeinschaftsbildende Kraft (“community-building power”), key Soviet musicologists such as Ivan Sollertinsky advocated applying a model from the Western symphonic tradition to meet national propagandist needs. With music analysis, I show how Shostakovich’s Fifth fits into Boris Asafyev’s conception of Soviet …


The Moral Economy Of Ordinary Belarussians And A Critical Examination And Re-Evaluation Of The 2020 Post-Electoral Uprising, Geoffrey Blank Sep 2022

The Moral Economy Of Ordinary Belarussians And A Critical Examination And Re-Evaluation Of The 2020 Post-Electoral Uprising, Geoffrey Blank

Dissertations, Theses, and Capstone Projects

This study is three studies in one: First, a qualitative study of the moral economy of ordinary Belarussians based on E.P Thompson’s class-based economic conception of moral economy, as applied to complex socio-economic systems by Reinarman (1987). Second, a critical and broad examination and re-evaluation of the August 9, 2020 post-electoral uprising. And third, an examination of both the West’s hostility toward Belarus’ largely state-owned socially-oriented economic model (often considered market socialism) and toward President Lukashenka, and, of the West’s commitment to overthrowing President Lukashenka and Belarus’ largely state-owned socially-oriented economic model, through its sponsorship of color revolution, “democratization,” regime …


A Queens Community Teacher Storytelling Project: A Qualitative Research Study Of Five Local Afro-Caribbean And Latina Public School Teachers And Community Teachers In New York City, José Alfredo Menjivar Ortéz Sep 2022

A Queens Community Teacher Storytelling Project: A Qualitative Research Study Of Five Local Afro-Caribbean And Latina Public School Teachers And Community Teachers In New York City, José Alfredo Menjivar Ortéz

Dissertations, Theses, and Capstone Projects

This dissertation thesis examines the lived experiences, life stories, and storytelling of five Afro-Caribbean and Latina people, who are all local from the borough of Queens, alumni of New York City’s public schools, and since then, became their local public school teachers, classroom practitioners, and local community teachers. We refer to this specific and unique population of teachers as alumni-community teachers and to these and other similar stories as teacher life stories.

This qualitative research and study were conducted through a series of writing workshops and semi-structured interviews. The study’s main examination is preoccupied to understand how local teachers make …


The International Academy Of Language And Culture: The Global (Pre)K-12 Charter School Network, Dree-El Simmons Sep 2022

The International Academy Of Language And Culture: The Global (Pre)K-12 Charter School Network, Dree-El Simmons

Dissertations, Theses, and Capstone Projects

The International Academy of Language and Culture (IALC) is a charter school based on the original concept of charter schools by Ray Budde and Albert Shanker, as an academic environment dedicated and designed to improving the educational outcomes for its students through innovative pedagogy. Committed to American (and global) education reform, the IALC incorporates elements from higher education into the early childhood and adolescent settings. We accomplish this by utilizing an interdisciplinary approach in our language and culture-based program.

The IALC is a multilingual, full-immersion program. Food Studies (including culinary arts), the Arts, the Humanities, Social Sciences, and Martial Arts …


Analog Matters: Labels, Cassettes, And Alternative Economies In Argentina’S Independent Music Scenes, Maria Agustina Checa Sep 2022

Analog Matters: Labels, Cassettes, And Alternative Economies In Argentina’S Independent Music Scenes, Maria Agustina Checa

Dissertations, Theses, and Capstone Projects

This dissertation is a multi-sited ethnographic study of current cassette production and circulation in Argentina. It analyzes the work of independent labels that record music available online onto cassette tapes, incorporating a variety of music styles. I examine practices of production, circulation, and exchange, and the alternative economies performed around cassettes, with particular attention to the materialities constituting these processes. Through cassettes, I conceptualize and trace "relational value," a notion to understand objects with different kinds of social agencies valued for their abilities to generate connections. Relational value is a theoretical construct that emerges from the ground-up approach to studying …


Development And Characterization Of A Novel, Genetically- Encoded Sensor To Image Sonic Hedgehog Signaling In Functional Circuits, Sonia Bernal Sep 2022

Development And Characterization Of A Novel, Genetically- Encoded Sensor To Image Sonic Hedgehog Signaling In Functional Circuits, Sonia Bernal

Dissertations, Theses, and Capstone Projects

Dynamic neurotransmitter and neuromodulator signaling in functional circuits is the neural substrate of animal behavior and cognition. The study of said circuits requires tools with sufficient spatiotemporal dynamics that can probe complex signaling patterns and decode their functional relevance by coupling the signal to behavioral output, ideally in awake, behaving animals. Much is known about the role of classical neurotransmitters such as dopamine in behavior, but a wide variety of peptides and small molecules also regulate neuronal transmission. One of these is Shh, whose presence has been observed in a variety of brain regions known to modulate movement, perception, and …


Carceral Calisthenics: Physical Culture In The Hood, Albert L. De La Tierra Sep 2022

Carceral Calisthenics: Physical Culture In The Hood, Albert L. De La Tierra

Dissertations, Theses, and Capstone Projects

How do racialized men who reside in structurally marginalized locales that are putatively regarded as “the hood” navigate and manage their social conditions? This dissertation sheds light on this question by treating “street workout,” a physical culture centered around calisthenics exercises performed in public space, as an empirical site for generating a situated understanding of how some Black men assert themselves in social space at the same time that they are asserted upon by social forces. Taking an ethico-onto-epistem-ological stance that refuses the colonial gaze (a ubiquitously employed optic that dehumanizes racialized people), this dissertation asks: (1) What embodied practices …


Determining The Roles Of The Oligomerization And C-Terminal Domains In Mutant P53 Gain-Of-Function Activities, George K. Annor Sep 2022

Determining The Roles Of The Oligomerization And C-Terminal Domains In Mutant P53 Gain-Of-Function Activities, George K. Annor

Dissertations, Theses, and Capstone Projects

The tumor suppressor p53 (TP53) gene is often mutated in cancer, with missense mutations found in the central DNA binding domain, and less often in the oligomerization domain (OD) and C-terminal domain (CTD). The OD and CTD have been found to be critical for the tumor suppressor functionality of wild-type p53 (wtp53). Specific missense mutations in the DNA binding domain have been found to confer new gain-of-function (GOF) activities. Mutations that destabilize tetramer formation, or deletion of key lysine residues within the CTD, downregulate the ability of wtp53 to transactivate (increase the rate of transcription of) its target …