Digital Commons Network^™

Elevidys: A Novel Gene Therapy For The Treatment Of Duchenne Muscular Dystrophy, Reese Weissenfluh, Joshua Boggs, Elizabeth Sartschev, Allison Provenzale, Marisa Petrunich, Brianna Lu, Joshua Honaker, Claire Marasco

Pharmacy and Wellness Review

Duchenne Muscular Dystrophy (DMD) is a severe muscle-wasting disease caused by dystrophin gene mutations. DMD occurs in one of 3,500 male live-born infants and has one of the highest prevalence of severe congenital myopathies. Two ongoing clinical trials have contributed to the United States (US) Food and Drug Administration’s (FDA) accelerated approval of Elevidys (delandistrogene moxeparvovec), a promising drug to treat DMD. Elevidys, a recombinant adeno-associated viral (rAA V) vector-based gene therapy, gained FDA approval based on findings from the ENDEA VOR trial (NCT04626674) and EMBARK trial (NCT05096221). The phase 1 ENDEA VOR trial focused on evaluating changes in dystrophin …

Oxidation Of Ethanolamine By Potassium Permanganate In The Presence And Absence Of Sodium Dodecyl Sulphate: A Kinetic Study In An Acidic Medium, Dayo Latona

Makara Journal of Science

The kinetics of ethanolamine oxidation by acidified KMnO₄ was investigated in the absence and presence of sodium dodecyl sulfate (SDS) was investigated using a pseudo-first-order kinetics approach, with [ethanolamine]_o >> [KMnO₄]_o. The measurements were conducted at λ_max = 525 nm using an ultraviolet/visible-1800 Shimadzu spectrophotometer. The stoichiometry showed that 2 moles of KMnO₄ were consumed by 5 moles of ethanolamine in the aqueous medium. The reaction orders in both the aqueous and micellar media remained the same with a first-order dependence on [KMnO₄] and [ethanolamine] and a fractional-order dependence on [H …

Could Ernest Boyer’S Foundational Perspective Of The Scholarship Of Teaching Help Save Faculty Librarians?, Douglas Wayman

The Christian Librarian

This is a recovery project for Ernest Boyer's scholarship of teaching as presented in Scholarship Reconsidered. It addresses a reinterpretation of Boyer’s scholarship of teaching promulgated by his Carnegie successor, Lee Shulman and popularized throughout the Academy. Serendipitously, that reinterpretation gave birth to what is now known as the Scholarship of Teaching and Learning (SoTL), which has undoubtedly benefitted the Academy. While this project focuses on the reinterpretation's ramifications for tenure-track academic library faculty who teach, it also argues that the foundational interpretation of Boyer's model could benefit the Academy at large, and that the two interpretations are not mutually …

Global Ethics, Religious Liberty, And Freedom Of Information Access, Paul A. Hartog

The Christian Librarian

Devout Christians work in a spectrum of library settings (including public libraries), networked by globalized information access. By nature of their employment, these librarians assist patrons in accessing and retrieving information that challenges or conflicts with a biblical worldview. How can one defend taking such an active role in this seeming contradiction? This article maintains that Christian commitment may not only co-exist with the freedom of information access but may also support it as a universal human right in our globalized, pluralistic context. To make the case, the essay contrasts two varying accounts of Global Ethics (differing in their view …

Electronic Resource Usage Data: An Introduction And Data Dashboard Template, Kelly Bilz

The Christian Librarian

This article provides an overview of COUNTER5 metrics and reports, describes the Usage Data Dashboard template, and provides several takeaways for designing data collection workflows. Drawing from research data management (RDM) principles surrounding documentation, the Usage Data Dashboard template can support library workers and improve processes of collecting and interpreting electronic usage data.

Insights: Qualitative Study To Reevaluate And Redesign Online Learning Self-Guided Tools For English First Year Writers, Nandi Prince

The Christian Librarian

Abstract

The library faculty teaches approximately three hundred one-time instructional classes per year. This study explored the role of the library instructor in the support of serving the needs of first year writers(FYW) in a discourse community (DC). The English faculty teach English Composition I, the FYW develop their writing skills in a community with shared goals and an established means of communicating. This qualitative study explored: (1) in-depth experiences of the English faculty during library one-time instructional classes; (2) their perceptions of what students need most, in the new curriculum; (3) new findings that would guide the design of …

Academic Library Book Digitization And Contemplative Reading, Robin Phillips

The Christian Librarian

Since the beginning of this century, academic libraries have been at the forefront of book digitization and access. During this same period, many individuals have made the transition from reading printed materials to reading on screens. This change in reading habits has led to profound shifts in how libraries conceive their mission, how they structure their spaces, how they organize their resources, and where they allocate funds in their budgets. These changes have been reflected in the Library and Information Science literature, which now includes a rich corpus of research on the impact of digitization on librarians and library services. …

Histological Study Of The Restorative Effect Of Roselle (Hibiscus Sabdariffa Linn.) Tea On The Digestive Organs Of Monosodium Glutamate-Induced Mice (Mus Musculus Linn.), Kanigara Anupama Sistra, Ngurah Intan Wiratmini, A. A.S.A. Sukmaningsih

Folia Medica Indonesiana

Highlights: • This original study examined the antioxidant compounds derived from naturally sourced Hibiscus sabdariffa calyx. • The findings demonstrated that roselle tea offers a viable and cost-effective solution for repairing histological damage to the digestive organs induced by monosodium glutamate. Abstract Monosodium glutamate (MSG) is a commonly used synthetic additive for enhancing food flavor. Excessive use of MSG can cause cytotoxic effects, which disrupt the balance of oxidative stress and free radicals in the body, particularly in the human digestive system. Roselle (Hibiscus sabdariffa) is a plant with red petals renowned for its abundance of beneficial compounds, including polyphenols, …

The Potential Of Endophytic Bacteria As The Biocontrol Agents Of Fusarium Proliferatum, Rima Ernia, Nisa Rachmania Mubarik, Lisdar Idwan Sudirman

Makara Journal of Science

Fusarium proliferatum decreases the productivity of shallot (Allium cepa L.). Endophytic bacteria are potential biocontrol agents in controlling the growth of F. proliferatum. This study aimed to select and characterize endophytic bacteria producing bioactive compounds that inhibit the growth of F. proliferatum. The endophytic bacteria used were isolated from the roots, stems, leaves, and soil of shallot plants from healthy and diseased shallot farming fields. The endophytic bacteria were selected using the dual culture method and extracted using ethyl acetate solvent. The results of the 16S rRNA identification suggested that isolate ABP5.2 is similar to Pseudomonas …

Influence Of Library Management System In Managing Library Information Resources By Librarians In Ekiti State Tertiary Institutions, Fajiwe Olabode Thomas, Ogunojemite Abosede Tola

Library Philosophy and Practice (e-journal)

The study investigated the influence of the library management system in managing library information resources by librarians in Ekiti state tertiary institutions. The study adopted the descriptive survey design. The sample for the study comprised 80 librarians who were randomly selected through simple random sampling. Purpose of Library Management System (PLIS) and Challenges of Library Management System (CLMS) were the two instruments used to collect relevant data for the study. The research questions raised were answered using mean and standard deviation. Means scores cut off point of 2.50 and above was accepted. The findings from the study indicated that …

Enhancing Information Delivery Services For Distance Education Programmes In Cross River State, Nigeria, Mayen Ndaro Igajah Dr, Christopher Okoi Offem Mr, Mary Mfon Bassey Mrs

Library Philosophy and Practice (e-journal)

The paper assessed information delivery services for distance education programmes. The study traces briefly the history of the National Open University and the National Teacher Institute. The e-resources and current issues on services provided by librarians. The study adopted the survey design methods. The questionnaire was used as an instrument for data collection. From the analysis of the data collected, it was found that the current issues on information services are in support of open and distance education programmes, technologies used in the delivery of information services for distance learners, concepts of distance education in Nigeria, value of social media …

Meet Our Cover Artist, Dorothy R. Arvidson

Bird Observer

No abstract provided.

Field Notes From Here And There, Nancy Claflin, Robert H. Stymeist, Richard F. Graefe, Dorothy R. Arvidson, Robert Abrams

Bird Observer

No abstract provided.

Field Records: September 1985, George W. Gove, Robert H. Stymeist, Lee E. Taylor

Bird Observer

No abstract provided.

World Series Of Birding 1985: A Tale Of Five Swifts And A Robin, John C. Kricher

Bird Observer

No abstract provided.

A Note On Wildlife Protection, John M. Grugan

Bird Observer

No abstract provided.

Report Of The North District Tern Warden: Season Of 1980, Dennis Minsky

Bird Observer

No abstract provided.

Report Of The North District Tern Warden Season Of 1979, Dennis Minsky

Bird Observer

No abstract provided.

A Townsend's Warbler In Massachusetts - A Retrospective Sighting, Craig Jackson

Bird Observer

No abstract provided.

Media Coverage Of Deepfake Disinformation: An Analysis Of Three South-Asian Countries, Ahmed Shafkat Sunvy, Raiyan Bin Reza, Abdullah Al Imran

Informasi

A lot of people are concerned about DeepFakes in modern society. Despite its wide range of uses, DeepFakes has gotten little public recognition. The main goal of this research is to analyze DeepFakes and their originators, as well as their potential and risks. We analyzed 203 news articles from 16 media outlets in Bangladesh, India, and Pakistan to achieve our goal. The extracted news had been categorized under threat, prevention, and entertainment centric news. It has been revealed after analyzing DeepFake-related news from the leading English daily of these countries that more than 50% news of Pakistani newspapers related to …

Ernst & Young’S Attempt To Split Accounting And Consulting Services: An Unsuccessful Endeavor, Jacob Jovanovich

Honors Capstones

This paper aims to address the reasons why Ernst & Young attempted to split their auditing and consulting services, the reasons why the split failed to materialize, and the resulting consequences. Research for the paper involved a literature review of relevant articles and subsequent discussion. This paper concludes that the attempted split was motivated by regulatory concerns regarding auditor independence and profitability gaps between assurance and consulting. This paper also concludes that the split was unsuccessful due to unfavorable economic conditions and the mechanics of partner compensation.

The Development And Evaluation Of Nurse-Created Video Modules To Encourage Healthy Behaviors Among Women With Polycystic Ovarian Syndrome (Pcos), Rebecca Akers

Doctoral Projects

Problem Statement: Women with PCOS have a higher prevalence of overweight and obesity, a problem that is directly linked with many of the symptoms and long-term health problems experienced by these individuals. Research studies indicate that lifestyle modifications, including dietary changes and increased physical activity aimed at promoting weight loss, are often the initial approach to treatment, but many women fail to adopt those health-promoting behaviors, which may be due to insufficient teaching and support provided by healthcare professionals.

Purpose: Utilize Pender’s Health Promotion Model to develop and evaluate a set of educational video modules focused on encouraging women with …

How Do Biased Police Lineups Effect The Accuracy Of The Eyewitness?, Brady Haskell

Psychology Student Publications

No abstract provided.

Are Animals The Best Therapists?, Debra Bigelow Davis

Psychology Student Publications

Scientific Communication Paper

Sirtuin 6 Activation Rescues The Age-Related Decline In Dna Damage Repair In Primary Human Chondrocytes, Michaela E. Copp, Jacqueline Shine, Hannon L. Brown, Kirti R. Nimmala, Oliver B. Hansen, Susan Chubinskaya, John A. Collins, Richard F. Loeser, Brian O. Diekman

Department of Orthopaedic Surgery Faculty Papers

While advanced age is widely recognized as the greatest risk factor for osteoarthritis (OA), the biological mechanisms behind this connection remain unclear. Previous work has demonstrated that chondrocytes from older cadaveric donors have elevated levels of DNA damage as compared to chondrocytes from younger donors. The purpose of this study was to determine whether a decline in DNA repair efficiency is one explanation for the accumulation of DNA damage with age, and to quantify the improvement in repair with activation of Sirtuin 6 (SIRT6). After acute damage with irradiation, DNA repair was shown to be more efficient in chondrocytes from …

Women In Leadership: How Far Have We Come And Where Do We Go?, Alexandra Hill

Undergraduate Honors Theses

Corporate leadership has evolved throughout the decades due to societal and organizational changes. With a shift towards a more equitable workplace, women have taken on higher executive roles. While there has been progress, women are still outnumbered in leadership positions. Where do we go from here? What can organizations and society do to advance the idea of leadership as a gender-neutral concept? This paper researches the evolution of leadership theory, the gender differences in women’s leadership styles, and the challenges women encounter in their positions of power. Through analysis of the internal and external barriers facing women’s advancement into and …

Clean Energy & Sustainable Environment By Carbon Dioxide Mitigation Strategies, Md Fahim Shahriar

Mechanical Engineering Theses

Dissolution trapping is one of the most dominant mechanisms for secure storage of CO₂ injected in porous subsurface formations saturated with brine. This study uses a 2D visual Hele-Shaw cell to investigate and visualize the impact of CO₂ injection locations, reservoir dipping angle, permeability heterogeneity, and brine with different initial ionic concentrations on the density-driven convection during CO₂ dissolution (Chapter 2). Also, the role of complex heterogeneity, i.e., irregular permeability distribution in CO₂ dissolution, is investigated using a novel experimental approach to create medium permeability heterogeneity in Hele-Shaw cells (Chapter 3). We observed that the presence …

Knowledge Of School-Based Occupational Therapists: Role In Concussion-Related Visual Impairments, Elise Cassidy, Kailyn Ebeling, Brenda O'Connell, Mackenzie Rutz, Alyson Snyder, Carla Floyd-Slabaugh

Masters Projects

Background: This study examined knowledge of school-based occupational therapists (SBOTs) regarding current concussion-related vision impairment practice patterns. There is a lack of literature on how SBOTs treat students who sustained a mild traumatic brain injury (mTBI), also known as a concussion.

Method: A mixed-methods survey was distributed online to SBOTs to understand what assessments and interventions are used for concussion-related visual impairments, the perceived role of SBOTs, and difficulties faced treating students with mTBIs.

Results: There were 124 potential participants that started the survey, and 35 (28.23%) completed the survey. Assessments and interventions used amongst therapists differed …

A Comparative Analysis Of The Water Use And Nutritional Value For California Commodities, Helen M. Lee, Giselle A. Pignotti, Kasuen Mauldin, John Gieng

Faculty Research, Scholarly, and Creative Activity

To create a more sustainable food system, this study analyzed the water use and nutritional data for California commodities. The data were separated into quadrants based on median scores, with results that include a list of commodities lower in agricultural water use while being higher in nutritional value. Because the agricultural sector is the dominant water user, there is an opportunity here to influence growers, consumers and policymakers to choose and support the growth of foods that would reduce water consumption while still providing beneficial nutrients. The goal of this paper is to educate the public on this important issue.

The Effect Of Material Nonlinearity On Stress Concentrations At A Bi-Material Interface, Jin Qian

McKelvey School of Engineering Graduate Student Theses & Dissertations

No abstract provided.