Digital Commons Network^™

Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi

Michigan Tech Publications

Mitochondrial dysfunction is associated with various health conditions, including cardiovascular and neurodegenerative diseases. Mitochondrial-targeting therapy aims to restore or enhance mitochondrial function to treat or alleviate these conditions. Exosomes, small vesicles that cells secrete, containing a variety of biomolecules, are critical in cell-to-cell communication and have been studied as potential therapeutic agents. Exosome-based therapy has the potential to treat both cardiovascular and neurodegenerative diseases. Combining these two approaches involves using exosomes as carriers to transport mitochondrial-targeting agents to dysfunctional or damaged mitochondria within target cells. This article presents a new technique for engineering brain-derived exosomes that target mitochondria and has …

Intouch Week Of December 11, 2023, New York Medical College

InTouch

• Key Discovery Could Offer Hope in Fight Against Alzheimer's Disease
• James Williams’ Journey from the NFL to NYMC
• Student Housing Fitness Center Gets a Makeover
• BioInc@NYMC Welcomes Marubeni America Specialty Chemicals Unit as Newest Client
• D.P.T. Class of 2025 Present Community Service Projects
• Student Spotlight: Kathleen Harwood Lead Authors Publications in Sports Medicine

Liquid Organic Matter From Banana Peel Improves Morpho-Physiological Traits Of Coffee Seedlings, Mochamad Arief Soleh, Inaz Nuzul Zalfa, Mira Ariyanti

Jurnal Kultivasi

Due to its economic advantage, the Robusta coffee clones BP 308 and BP 939 are widely grown. Many factors affect coffee growth during the cultivation practice, especially in the availability of adequate nutrients at the nursery stages. Apart from inorganic fertilizer application, organic matter needs to be applied in the nursery stages to support plant growth, such as applying liquid organic matter (LOM) derived from banana peel waste. This study was conducted to find out how the LOM of banana peels affected the morphological and physiological responses of BP 308 and BP 939 clone Robusta coffee seedlings and what proper …

The Effect Of Reading Habits On Academic Success, Taylor Hicks

Masters Projects

The goal of most students is to achieve academic success. In order to be successful, students must form healthy reading habits because there is a positive correlation between academic success and reading habits. The more students read, the greater their chances of performing well academically. By participating in frequent reading, students will, not only perform well in school, they will also expand their vocabulary, improve their writing skills, and sharpen their critical thinking skills. We are in the midst of a literacy crisis, though. Students are choosing other avenues for entertainment instead of reading. This could potentially have detrimental consequences. …

Review Of "Faith And Fake News: A Guide To Consuming Information Wisely", Katherine J. Graber

The Christian Librarian

No abstract provided.

Assessing Generalization Of Behavioral Interventions In Teaching Independent Play Skills To Individuals With Autism Spectrum Disorder: A Systematic Review, David Anthony Defranco

Seton Hall University Dissertations and Theses (ETDs)

A myriad of evidence-based practices has been effective in teaching independent play skills to individuals with Autism Spectrum Disorder (ASD). These interventions include video modeling, activity schedules, task correspondence training, task organization, individual work systems, and matrix training. This systematic review is aimed at examining the various behavioral interventions used to teach independent play skills to children and adolescents with ASD as the independent play literature will be evaluated to see if generalization was programmed for and assessed within the study. As one of the main dimensions of behavior analysis, generalization of skills, specifically independent play skills, is important to …

The Structure Of Secondary Copyright Liability, Felix T. Wu

Articles

Secondary copyright liability and secondary patent liability largely parallel each other. And yet, secondary copyright cases are often quite different from secondary patent cases. Whereas most secondary patent infringers act in a way that targets a particular patent or group of related patents, secondary copyright infringement mostly arises in the context of technologies or services that work across all copyrighted works. Secondary copyright liability raises issues of platform liability in ways that secondary patent liability usually does not.

The current structure and framing of secondary copyright liability inadequately account for this distinction. The result is that secondary copyright liability tends …

Interactive Effects Of Npk Fertilizer And Paclobutrazol Concentration On Growth And Yield Of Hanjeli (Coix Lacryma-Jobi L.), Medita Johana Pakula Bafiqi, Tati Nurmala, Muhamad Kadapi

Jurnal Kultivasi

The balance between growth and crop yield can be manipulated by exploiting nutrient and retardant interactions. This study is aiming to assess the effects of various combinations of NPK 16-16-16 fertilizer in different doses, along with the application of multiple concentrations of paclobutrazol on the growth and yield of hanjeli. This experiment was carried out in the experimental field of Ciparanje, Faculty of Agriculture Universitas Padjadjaran, Jatinangor, Sumedang from February 2021 to August 2021. This research was conducted in a split-plot design with three replications. The main plot consisted of 200 kg ha-1, 250 kg ha-1, and 300 kg ha-1. …

Micromagnetic Investigation Of The Dynamics Of Domain Walls And Substructures In Non-Uniform Magnetic Thin Films, Trae Staggers

Electronic Theses and Dissertations Archive

Since the discovery of gigantic magnetoresistance and the advent of spintronics, magnetic materials have become ubiquitous in modern technology. As such, a wide range of research areas within this field are being continuously explored for potential means to improve device scaling, decrease energy consumption, or increase speed, as well as to understand the fundamental physics governing spin order at the micro- and nanoscale. One of the avenues under current investigation involves the use of the spin-orbit interaction in systems with broken inversion symmetry through the introduction of interfaces or compositional variations. I will introduce the theory of micromagnetism and demonstrate …

"Sometimes Human Places Create Inhuman Monsters': An Examination Of The Monstrous And The Abject In American Literature, Carol Wardell

Electronic Theses and Dissertations Archive

“‘Sometimes Human Places Create Inhuman Monsters’: An Examination of the Monstrous and the Abject in American Gothic Literature” defines “characters” in select texts as monstrous beings. These identified beings engage Julia Kristeva’s abject and differ from a grotesque. Whereas a grotesque character is often supportive in relation to the development of the story, the characters I have identified are crucial to the text. Without these characters and the abjection these monstrous beings evoke, the story would not develop in the same manner, have the same repercussions, nor have the same representation of cultural anxieties. In order to develop a definition …

Employment Leave For Early Pregnancy Endings: A Biopolitical Reproductive Governance Analysis In England And Wales, Al Middlemiss, I Boncori, J Brewis, J Davies, Vl Newton

School of Nursing and Midwifery

When a pregnancy ends in England and Wales, statutory time away from paid employment is limited to circumstances where there is a live birth or stillbirth. Forms of leave, such as Maternity Leave or Paternity Leave, depend on parental status derived from the civil registration of a new person or a post-viability stillbirth. Other early pregnancy endings, such as miscarriage or abortion, do not provide specific time off work after pregnancy. This paper uses the concept of reproductive governance to analyze current and shifting biopolitical truth discourses, strategies of intervention, and modes of subjectification around post-pregnancy leaves. It shows how …

Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi

Michigan Tech Publications

Mitochondrial dysfunction is associated with various health conditions, including cardiovascular and neurodegenerative diseases. Mitochondrial-targeting therapy aims to restore or enhance mitochondrial function to treat or alleviate these conditions. Exosomes, small vesicles that cells secrete, containing a variety of biomolecules, are critical in cell-to-cell communication and have been studied as potential therapeutic agents. Exosome-based therapy has the potential to treat both cardiovascular and neurodegenerative diseases. Combining these two approaches involves using exosomes as carriers to transport mitochondrial-targeting agents to dysfunctional or damaged mitochondria within target cells. This article presents a new technique for engineering brain-derived exosomes that target mitochondria and has …

Humankind – Bias In Our Head, Luying Li

Theses

"HumanKind" is a dynamic exploration at the intersection of visual communication design and societal awareness, seeking to unravel and mitigate the far-reaching impacts of bias. Through the fusion of "Human" and "Kind," the project embodies a dual narrative, emphasizing individual humanity and the diverse fabric of the human collective. The core inquiry revolves around encouraging individuals to recognize and challenge biases before decision-making, fostering unbiased choices. Historical narratives of racial conflicts serve as the foundation, propelling the project's mission to explore, challenge, and diminish biases entrenched in our collective consciousness. Going beyond traditional exhibitions, "HumanKind" evolves into a dynamic dialogue …

Information Communication Technology Competence And Reference Service Provision In Federal Universities In North-Central Nigeria., Ezinwanyi Madukoma, Catherine Enatta Ikokoh

Library Philosophy and Practice (e-journal)

The study investigates information communication technology competence and reference service provision in Federal Universities in North-Central, Nigeria. Reference librarians now provide users with databases that give access to millions of journal articles as well as access to the internet which has holdings of libraries and a limitless variety of formal and informal sources of information. The study has one objective, a research question and one hypothesis. The study adopted total enumeration using a descriptive survey design. The population of the study is three hundred and sixty library personnel comprising professionals and para-professionals. Three hundred and six questionnaires were returned and …

Disclaimer, Shaun Haurin

Valparaiso Fiction Review

No abstract provided.

You Bury Me, William O'Reilly

Valparaiso Fiction Review

No abstract provided.

Which Internet Content Is Often Used And Influenced Behavior? A Phenomenology About Students In Senior High School, Aris Martina, Siti Irene Astuti Dwiningrum, Heri Retnawati, Caly Setiawan

Informasi

At present, most students in the world, as well as Indonesia, especially senior high school students, have used the Internet for various purposes. Internet content presented on different platforms can now be accessed easily. Consciously or not, this media content influences their behavior. There is a lot of freely submitted content, which is worth knowing the impact. The question related to this study is which internet content is often used and affects high school students’ behavior. Qualitative methods with phenomenology have informants from the western, central, and eastern parts of Indonesia. Data were collected using observation, Google Forms, and interviews …

Shading The Future: A Gis-Based Approach To Optimal Tree Planting For Urban Heat Mitigation At Northern Michigan University, Mary Kelly

Conspectus Borealis

Increasing tree canopy cover is a powerful tool for mitigating the effects of urban heat on the natural and built environment, specifically the effects of ecosystem stress and air quality. Heat can also place stress on human health. Northern Michigan University (NMU) is proposing to build a new tree nursery on campus, which would help alleviate urban heat in Marquette. Finding suitable areas at NMU to plant new trees from this nursery is an essential component of this effort. A goal of my project was to provide this helpful information. Using GIS and remote sensing techniques in ArcGIS Pro and …

What The World Has Learned About Their Governments During The Covid-19 Pandemic, Olga Shvetsova

Political Science Faculty Scholarship

As we take stock of all aspects of the COVID-19 pandemic history, one important lesson to be learned concerns government behavior. While defense by immunity was in the works in vaccine research labs, defense by government action took the front seat, and political incumbents in every country and locale became "doctors to the public.” Did some governments perform better than others? Were there any predictable or explainable shortcomings in their crisis responses? Will governments and countries that underperformed in this crisis fall short in other crises where responsible leadership might be required? The contributors to this volume compare and contrast …

Evaluating Militant Decision-Making With Information Science: The Irish Republican Movement During The "Troubles", Joshua C. Eastin, Emily Kalah Gade, Michael Gabbay

Political Science Faculty Publications and Presentations

Why do militant groups decide to escalate or deescalate their use of violence in conflict? Examining the case of the “Troubles” in Northern Ireland, we analyze groups that adopt violence as a political strategy and evaluate factors that influence its application. To do so, we adopt a novel empirical approach to the study of militant groups. Drawn from information science, this approach enables estimation of variable influence and uncertainty within structured case studies, and is thus ideal for topics such as militant decision-making where systematic data collection is difficult.

Sounding Ethics: Musical Signification Of Moral Choices In Video Games, Hayden Mesnick

Honors Projects

Interactivity is what distinguishes video games as a medium. In “moral choice video games,” or games in which the moral alignment of player choices affects plot and gameplay, the music often reflects the branching storylines. While scholarship exists that explores musical signifiers in video games, and scholarship alike exists that investigates moral choice video games, a gap in literature exists at the juncture of these two topics. This paper explores two moral choice video games—Undertale (Toby Fox, 2015) and Red Dead Redemption 2 (Rockstar Games, 2018)—in order to identify musical signifiers used by each game’s composer to represent these levels …

The Discursive Fallacies Surrounding «Gender Ideology», Maricel Mena-López, Fidel Mauricio Ramírez Aristizábal

Conexión Queer: Revista Latinoamericana y Caribeña de Teologías Queer

Discourses surrounding «Gender Ideology» in Latin America display regional nuances, infiltrating various social strata. In Colombia, misinformation taints the narrative, exacerbated by the absence of a robust counter-movement to untangle the intricate discourse. This article traces the concept’s evolution, examining its impact on Colombian and broader Latin American religious fundamentalism. By exposing prevalent discursive fallacies, the objective is to contribute academically to the debate on a potent strategy that —in recent years — has aimed to hinder progress and erode the rights of women and the LGBTIQ+ community. The analysis illuminates a significant challenge impeding societal advancement.

«Escándalo, Es Un Escándalo»: Encarnación, Liberación Y Evangelio Desde Una Perspectiva Teológica Queer/Cuir, Hugo Cordova Quero, Cristian Mor, Anderson Fabián Santos Meza, Saúl Serna Segura

Conexión Queer: Revista Latinoamericana y Caribeña de Teologías Queer

This article explores the inherent scandal within theological discourse, particularly regarding the portrayal of Jesus as both human and divine and the necessity to acknowledge his humanity alongside his divinity. Throughout Western history, individuals of diverse gender and sexual identities have been marginalized within Christianity, underscoring the need for theological discourse to evolve alongside social dynamics and policies. In the Global South, Latin America and the Caribe emerge as a locus of diverse theological perspectives challenging hegemonic narratives, notably cis-heteropatriarchal and Eurocentric theologies. Queer theologies from this context aim to dismantle oppressive power structures and advocate for inclusivity and dignity …

Libertades Clandestinas: Hacia La Elaboración De Una Teología Queer Encarnacional, Marilú Rojas Salazar

Conexión Queer: Revista Latinoamericana y Caribeña de Teologías Queer

This article seeks to explore critical notions for developing a queer incarnational theology perspective. It begins by examining the concepts of «freedom» and «clandestinity» and then moves into the posthuman question, drawing on ecological feminism and queer/cuir theologies. In the final section, ideas are outlined that contribute to a queer incarnational theology, recovering the prophetic sense of the Gospel. This approach integrates freedom from a queer/ cuir perspective into a theological framework that resonates with human diversity and embraces the interconnectedness of all forms of life, challenging oppressive structures and recognizing the prophetic vitality of the Gospel.

Episode 6: For The Kids, Sara Gras

Season 01

When I started thinking about how to address the issue of trans exclusion from youth sports, I knew I needed to include the culture/industry of youth sports as part of the discussion. The pressure to compete and perform at a high level in athletics is reaching kids earlier than ever before, facilitated by parents who see success in sports as the ticket to success in life. This episode explores the relationship between the increased parental investment in kids' athletic achievements and the social acquiescence to the exclusion of trans kids from sports.

Kirsten Jones
Peak Performance Coach, Podcast Host, Author …

Hypertension And Lipid Profiles In Middle-Aged Male Patients: A Study At A Tertiary Hospital In Surabaya, Indonesia, Arin Nurtya, Artaria Tjempakasari, Ummi Maimunah, Sulistiawati, I Made Subhawa Harsa

Folia Medica Indonesiana

Highlights: 1. Uncertainty regarding the association between hypertension and the levels of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) signifies the need for more research, particularly in the realm of sex-specific analysis. 2. Our study uncovered significant associations between hypertension and the levels of total cholesterol and triglycerides, expanding our understanding of the impact of lipid profiles on hypertension. 3. This research may potentially pave the way for personalized diagnostic and therapeutic strategies, ultimately enhancing hypertension management and patient outcomes. Abstract Hypertension is one of the most frequent non-communicable diseases and a risk factor for cardiovascular disease, contributing to most …

Ddx170.2 Principles Of Design: Logo Design Example 1, Sae University College

Exemplars

DDX170 Project 2: Logo Design.

2023-December-10-Illuminating The Path I Want To Take, University Marketing And Communication, East Tennessee State University

ETSU News

Internships are the strength of ETSU’s Applied Data Science grad program

It’s an age-old conundrum. Employers want to hire candidates with experience. But how do you get that experience without someone giving you a chance?

One way is internships, many of which are available to students in academic programs throughout East Tennessee State University. One of those is ETSU’s Applied Data Science Master’s Degree Program, where students are getting valuable experience from the hands-on work they’re doing with entities from local small businesses and government to internationally known companies.

Applied data science is the study of techniques for collecting, …

Development Of Discharge Planning For Stroke Patients, Muhammad Imron Rosadi, Fitri Arofiati

Folia Medica Indonesiana

Highlights: 1. Given the frequent long-term complications of stroke, this study identified the ideal approach to discharge planning to improve the quality of life of patients and hospital care. 2. This study provides evidence supporting the effectiveness of a conventional discharge planning approach that incorporates specific educational intervention with interactive learning through audiovisual media. 3. The approaches presented in this study may offer valuable perspectives on enhancing health service provisions, particularly regarding the discharge planning process for nurses. Abstract The quality improvement of discharge planning is essential throughout the development of discharge planning, which guarantees a seamless transition of care …

The Effect Of Wildfires On Human Health, Samantha Mccord, Abigail Akamine, Branden Kadlubowski, Jack Hutchins, Maria Nguyen, Brianna Lu, Joshua Honaker, Karen Kier

Pharmacy and Wellness Review

On average, 70,000 wildfires occur each year in the United States (US). Given the rise in the frequency and severity of wildfire destruction observed in recent decades, it is crucial for US healthcare providers to be aware of the risks associated with wildfire smoke exposure. The majority of fire deaths are caused by inhalation of hazardous air pollutants (HAPs), including carbon monoxide (CO) and cyanide (CN), which can debilitate victims and impair their ability to successfully escape the flames. Research indicates that an increased number of visits to the emergency department, occurring two to three days after a wildfire incident, …