Digital Commons Network^™

Computational Study Of Fluorescent Molecular Probes For The Early Detection Of Alzheimer's Disease, Gabriela Elizabeth Molina Aguirre

Open Access Theses & Dissertations

Alzheimer's disease is a debilitating brain disorder that affects memory, thinking, and behavior. It is the most prevalent form of dementia and the seventh leading cause of death in the United States. As, researchers have identified biomarkers that can indicate the presence of the disease many years before the first symptoms appear, so there is an opportunity for early detection and treatment follow-ups, which could significantly improve the quality of life for those affected by this disease.This dissertation investigates the relationship between molecular structure and optical properties of donor-bridge-acceptor (DBA) fluorescent molecular probes designed for detecting Amyloid-β and p-Tau protein …

Dynamic Storytelling Algorithms Using Contextual Aspects Of A Large Language Model, Alireza Pasha Nouri

Open Access Theses & Dissertations

Storytelling is a set of algorithms used to create narratives by connecting documents in a sequencethat accurately reflects the evolution of events and entities within a particular topic or theme. Early storytelling algorithms face challenges in encoding the progression and interconnections of information between consecutive texts, given that the conventional approaches rely primarily on connecting document pairs based on content overlap. They often neglect critical linguistic features, such as word contexts, semantics, the roles words play across different documents, and attention to the historical contexts of the underlying documents. Many existing storytelling models frequently produce story chains that, while connected …

Energy Optimization In Pneumatic Systems Using Ens-200 Energy Saving Trainer, Maha Guru Shankar Perumal

Open Access Theses & Dissertations

Various industries such as manufacturing and assembly, the automotive sector, printing and paper handling, packaging, aerospace, etc., widely use pneumatic systems for a variety of operations. Enterprises use pneumatic systems for cost-effectiveness, reliability, and simplicity. However, they also have certain inefficiencies, leading to high operating costs and reduced efficiency in various applications. The focus of this research is on energy optimization in pneumatic systems to improve efficiency in industrial applications, minimize energy waste, and reduce operational costs. The best practices for enhancing energy efficiency in pneumatic systems were proper system design, pressure regulation, leak detection and repair, energy-efficient components, and …

Investigating Changes In Surface Water Chemistry Across The Llano Uplift And The Balcones Fault Zone In Central Texas Using Strontium And Uranium Isotopes, Hao Tuan Pham

Open Access Theses & Dissertations

The landscape of central Texas is shaped by over one billion years of Earth's history. An array of lithology lies within central Texas along with two large geological structures. The Llano Uplift, characterized by Proterozoic metamorphic and igneous rocks dating back to 1.37 billion years ago, is encircled by Paleozoic and Mesozoic sedimentary rocks. To the southeast of the Llano Uplift lies the Balcones Fault Zone (BFZ), an extensional structural system of mostly normal faults that delineates the transition between Paleozoic-Mesozoic sedimentary rocks and Cenozoic sedimentary cover, which are influential to the regional hydrogeology. This study investigates the hydrogeological dynamics …

Mav Localization In Gps-Denied Environments And Synthetic Data Collection In Challenging Simulated Conditions, Julio A. Reyes Munoz

Open Access Theses & Dissertations

The development of unmanned aerial systems presents an opportunity for conducting industrial inspections in environments where traditional navigation systems, such as the Global Navigation Satellite System (GNSS), are compromised. This dissertation investigates the implementation of a micro aerial vehicle (MAV) capable of autonomous data acquisition in complex, GNSS-degraded industrial settings. The primary challenge addressed is the robust localization of MAVs, a critical aspect in ensuring reliable operation under varying and uncertain environmental conditions.

The work is divided into two main parts. The first part focuses on the design and integration of a MAV system specifically for power plant inspections in …

Synthesis Of Neoglycoproteins As Potential Biomarkers For Chagas Disease And Cutaneous Leishmaniasis Caused By Leishmania (Viannia) Braziliensis, Eileni Rodriguez Gil

Open Access Theses & Dissertations

Protozoan parasites are responsible for causing numerous diseases in humans and mammals worldwide. Among them are Chagas disease (CD), caused by the parasite Trypanosoma cruzi (T. cruzi), and tegumentary leishmaniasis (TL), caused by the parasite Leishmania (Viannia). Both diseases coexist in many regions of Latin America, and current hurdles to differentially diagnose them and determine chemotherapy success need to be overcome. CD can be diagnosed by traditional serological tests and polymerase chain reaction (PCR), but disadvantages of these methods are that they may produce false negatives because the antigens used in commercial CD kits are not conserved across all T.cruzi …

Produced Water: Characterization And Treatment, Ramon Antonio Sanchez Rosario

Open Access Theses & Dissertations

In recent years, environmental concerns have urged companies in the energy sector to modify their industrial activities to facilitate greater environmental stewardship. For example, the practice of unconventional oil and gas extraction has drawn the ire of regulators and various environmental groups due to its reliance on millions of barrels of fresh water for hydraulic fracturing well stimulation, which is generally withdrawn from natural sources and public water supplies. Additionally, this process generates two substantial waste streams, which are collectively characterized as flowback and produced water. Whereas flowback water is comprised of various chemical additives that are used during hydraulic …

Characterizing The Mentoring Landscape In An Online Biology Cure: An Examination Of Student And Graduate Teaching Assistant Perspectives And Outcomes, Karen Alejandra Santillan

Open Access Theses & Dissertations

Both undergraduate research experiences (UREs) and course-based undergraduate research experiences (CUREs) provide students with benefits and opportunities such as improving technical skills and making connections that provide resources. Where these two experiences differ is accessibility. Similar to their URE counterpart, CUREs entail mentorship on the part of the faculty/graduate teaching assistant (GTA) instructor (Dolan, 2016). There is general agreement that mentoring has many benefits for undergraduate STEM students, such as an improvement in retention rates, increased confidence and self-efficacy, and a more established sense of belonging and science identity (Dolan, 2016). CURE instructors often adopt the role of “mentor” in …

Physics-Guided Scan Paths Optimization For Controlled Microstructure In Laser Powder Bed Fusion, Augustine Twumasi

Open Access Theses & Dissertations

Laser Powder Bed Fusion (L-PBF) is a renowned additive manufacturing technique, celebrated for its capability to construct intricate metal components with remarkable precision. However, one of the main challenges with L-PBF is the formation of complex microstructures, which can significantly impact the final material properties. To address this issue, our study proposes a physics-guided and machine-learning-aided approach to optimize scan paths for achieving desired microstructure outcomes, such as the generation of equiaxed grains that enhance material properties. By using phase-field modeling, a physics-based computational method, we gain insights into microstructure evolution. To reduce computational costs, we train a surrogate machine-learning …

Automated Composition Of Multivariable Scientific Workflows Considering Scientific Assumptions, Raul Alejandro Vargas Acosta

Open Access Theses & Dissertations

Many ground-breaking scientific experiments require the execution of multiple complex scientific computations. Thus, scientific workflows (i.e., a sequence of scientific computations) have received significant attention, more specifically, the automated composition of scientific workflows. Scientific workflows that repurpose data may have unique scientific assumptions that need to be considered when composing a workflow. Workflow composition tools have enabled a wider range of stakeholders (e.g., policymakers, the general public, and researchers) to create and execute workflows; however, domain expertise is still required for these tasks. The overarching goal of this work is to further improve the automatic composition of scientific workflows by …

Race, Severe Mental Illness, And Crime: An Intersectional Look Into Stigma And Policy Implications, Elena Therese Vaudreuil

Open Access Theses & Dissertations

Criminal behavior has been a long-discussed topic in the United States and often is tied to characteristics such as race and mental illness. The presumed connection between criminal behavior and being a member of a racial minority group or having a mental illness have been researched for years, however few researchers have sought to take an intersectional approach to investigate the unique experiences of people belonging to both groups in the criminal legal system. Using the lenses of attribution and intersectionality theories, the proposed studies sought to understand the effect of race that influences policy support of justice-involved people with …

Analyzing The Impact Of Oil And Gas-Contaminated Fluids On Soil In Eddy And Lea Counties Using Sequential Extraction, Mary Adu-Gyamfi

Open Access Theses & Dissertations

The study investigates the impacts of oil and gas-contaminated fluids on soil within the context of Eddy and Lea Counties in New Mexico, the United States. The increase in oil and gas operations has led to enormous wastewater production that is handled, stored, and transported, leading to thousands of spills yearly. The continuous and accidental release of this wastewater poses several risks to the environment due to its high levels of hazardous pollutants. Several studies were conducted on how to reduce the contaminants; however, the impact caused on the environment and the fate of the spilled fluids is unclear due …

Nationwide Practices And Perspectives On Early Literacy Activities In Daycare, Analaura Amador

Open Access Theses & Dissertations

No abstract provided.

Dispersal And Population Structure Of Euchlanis Chihuahuaensis Via Anemochory In The Chihuahuan Desert, Tristan Chavez-Poeschel

Open Access Theses & Dissertations

Desert ecosystems present challenges for aquatic organisms as habitats are fragmented, both in space and time; however, diapausing stages of rotifers can travel hundreds of kilometers during wind events. I used the rotifer Euchlanis chihuahuaensis as a model species to investigate the influence of wind dispersal on gene flow and population genetics in Chihuahuan Desert populations. I hypothesized that anemochory facilitates gene flow from source populations in the Northern Chihuahuan Desert in Mexico and the western United States to habitats in the Trans-Pecos region via delineated wind corridors. To test this hypothesis, the genetic diversity of populations from both inside …

Water Sufficiency For Organismal Function In Dryland Critical Zones, Lindsey Dacey

Open Access Theses & Dissertations

Water availability is crucial for organismal survival and growth in dryland environments, affecting both ecological interactions and carbon dynamics. The goal of this thesis is to develop soil water release curves (SWRCs) that link soil water potentials (Ψ) to soil water content (θ). Using the SWRCs, temporal soil water sufficiency curves are developed, which quantify the amount of time that dryland critical zones have enough water to sustain the physiology of organisms. These curves allow for effectively indicating water availability across different species, coverage types, and soil conditions, enhancing our understanding of water dynamics in drylands and contributing important parameters …

Depositional Facies And Petrophysical Characterization Of The Leonardian Carbonate (Lower Clear Fork), Tex-Mex, S.E. Field, Central Basin Platform, West Texas, Seyram Nyamasekpor

Electronic Theses and Dissertations

The Lower Clear Fork from Tex-Mex, S.E. Field on the Central Basin Platform is a typical complex reservoir that displays high heterogeneity in lithological and petrophysical properties. The unit represents a producing reservoir succession of Leonardian platform carbonates deposited in shallow marine water during the Early Permian. The sediment of the Lower Clear Fork is composed of a mixed succession of dolomite interbedded with anhydrite, minor clay minerals, and siliciclastics. The high heterolithic nature of the reservoir makes efficient recovery of hydrocarbons difficult. This situation requires an understanding of the variability in depositional facies in terms of mineralogy, depositional textures …

Formalization Of A Security Framework Design For A Health Prescription Assistant In An Internet Of Things System, Thomas Rolando Mellema

Electronic Theses and Dissertations

Security system design flaws will create greater risks and repercussions as the systems being secured further integrate into our daily life. One such application example is incorporating the powerful potential of the concept of the Internet of Things (IoT) into software services engineered for improving the practices of monitoring and prescribing effective healthcare to patients. A study was performed in this application area in order to specify a security system design for a Health Prescription Assistant (HPA) that operated with medical IoT (mIoT) devices in a healthcare environment. Although the efficiency of this system was measured, little was presented to …

Compound Marine Cold Spells And Hypoxic Events In A Nearshore Upwelling System, Ryan K. Walter, Michael Dalsin, Piero L.F. Mazzini, Cassia Pianca

Physics

Prolonged periods of extreme warm and cold seawater temperature anomalies, known as marine heatwaves (MHWs) and marine cold spells (MCSs), respectively, can have significant impacts on coastal marine ecosystems. Prior research has examined the co-occurrence of multiple extremes [low dissolved oxygen (DO) and/or low pH] during MHWs, with the impact of these compound events potentially exceeding that of a single stressor due to synergistic effects. However, we are not aware of any studies that have examined compound extreme events during MCSs, despite the ecosystem implications. Along Eastern Boundary Current Upwelling Systems (EBUS), strong-wind driven upwelling has led to …

An Inconvenient Truth About ‘Bundling’ Commitment, Engagement, & Embeddedness: Unbundling To Extend Theory On Turnover Motivations And Beyond, Carl Maertz, Clark D. Johnson, Brittney C. Bauer

School of Business: Faculty Publications and Other Works

This paper critiques a research practice that we call “bundling,” which has produced highly popular constructs in the organizational behavior literature, including organizational commitment, employee engagement, and organizational embeddedness. We show how these bundled constructs, using broad labels from common parlance, have produced overlapping meanings, confounded theoretical mechanisms, and imposed limiting “ideal employee” conceptions in the literature, organizations, and ultimately, societal discourse about employees. We argue that “unbundling” these constructs can provide multiple benefits to theory, empirical inquiry, and practical assessment of complex employee motives. As a demonstration, we unbundle the three focal constructs to integrate and clarify their component …

Adding Parasite Resistance To A Hair Sheep Breeding Objective, Robert M. Forbes

Department of Animal Science: Dissertations, Theses, and Student Research

The United States Hair Sheep Index was designed to increase total weight of lamb weaned per ewe lambing (TW) using estimated breeding values (EBV) for direct (DWWT) and maternal (MWWT) weaning weight, and number of lambs born (NLB) and weaned (NLW), as selection criteria. Producers are interested in adding post-weaning fecal egg count EBV (PFEC), an indicator of parasite resistance, to the index to achieve genetic change in both TW and PFEC.

First, the effects of adding PFEC alongside TW to the breeding objective of indexes that used either phenotypes or EBV as selection criteria were studied. Since MWWT …

Sports Science: An Entrepreneurial Venture, Nicole J. Jones

Senior Honors Projects

In sports science, ensuring maximum athlete safety and optimizing data utilization are pivotal yet leave room for further work. My project, Unbeaten SafeWare, addresses these critical issues by focusing on two primary concerns: preventing heat-related and cardiac illnesses, which are significant causes of athlete fatalities, and enhancing the transparency and utility of sports data. This initiative involves developing a shirt integrated with sensors to monitor vital signs and an athlete management system to handle data input, storage, analysis, and accessibility for athletes.

The project has advanced through the efforts of a multidisciplinary team, which includes biomedical engineering undergraduates, two faculty …

Comparing The Regulatory Effects Of Overexpressed Micrornas And Xenobiotic Drugs On Cell Cycle And Apoptotic Regulators In Pc-3 Cells, Tommie Johnson

Dissertations (2016-Present)

MicroRNA was first discovered in C. elegans as small temporal RNA (stRNA) that does not code for protein. Since being discovered they have played a significant role in regulating gene expression at the post-transcriptional level. miRNAs are found in various organisms, and they bind to the 3' untranslated regions to inhibit translation and cause mRNA degradation. Some drugs are involved in cell cycle regulation such as Palbociclib, Ribociclib (LEE011), and Abemaciclib (LY2835219), that causes G1 arrest impeding cell proliferation. Cyclin D1 (CCND1) is supported by the cell cycle making it into a functional product. When undergoing a chemical reaction, the …

Development And Pilot Testing Of A Surface Discrimination Test For People With Lower Limb Amputation, Colin Kruger, Kyle Mcknight, Sharlene Lim, Samuel Straus

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: There is a lack of understanding as to how sensory loss and sensory deficits impact those with LLA. The purpose of this research is to determine the extent to which people with LLA can discriminate between surfaces underfoot, in order to better understand the relationship between people with LLA and their perception of the ground they are walking on. We developed a test to determine which qualities of surfaces may be easier to distinguish.

Methods: 10 unimpaired adults and 2 adults with LLA participated. Participants compared surfaces underfoot that consisted of ceramic, rough tile, gravel, sand, and sandpaper to …

Simulation And Design Of Ion Traps Using The Method Of Fundamental Solutions, Trevor Taylor

UNLV Theses, Dissertations, Professional Papers, and Capstones

In this thesis I apply the numeric method, the Method of Fundamental Solutions (MFS), to solve for the fields create by ion traps in various configurations, such as quadrupole ion traps, linear ion traps, toroidal ion traps, and toroidal surface ion traps. The traps are then designed to maximize desired qualities such as minimization of their anharmonicity, and their ability to shuttle ions. A particular focus will be on the toroidal surface ion trap, as well as its ability to shuttle ions. This trap is planned for future experiments involving measurement of the electron Electric Dipole Moment.

Nonlocal Frameworks For Differential Equations--Analysis And Numerical Investigations, Layla Montemayor

Honors Program: Senior Projects (Public)

Systems of differential equations have been employed successfully in nearly every scientific field, including natural phenomena, finance, A.I. and machine learning. In a classical set up, a differentiable equation will be associated with a number of initial conditions that will help determine a unique solution to the system. The setting of classical differential equations requires assumptions on the regularity or smoothness of the input functions. Thus, we cannot produce with classical differential equations solutions which are irregular or even have discontinuities.

To overcome some of these challenges brought up by investigations of irregular or singular behavior, different formulations of nonlocal …

Supporting The Creative Side Of Creative Coding: Helping Students Wield Code In The Pursuit Of Their Own Dreams, Gretchen K. Larsen

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Creative coding has become more common in art and new media schools, however research describing how teachers navigate the unique challenges of teaching code as a creative medium is limited. This paper presents the details of a creative coding course designed to support the ‘creative’ side of creative coding. As a result of this research, I present a framework for supporting the ‘creative’ side of creative coding, which connects to arts-based education theories, modified for the creative code context. This paper asks—what helps students use creative coding as an artistic medium in the pursuit of their own questions and meaning? …

More Than A Monolith: Three Essays On The Diverse Journey Of Immigrant Students And Their Postsecondary Outcomes, Rian Rinaldi Djita

Graduate Theses and Dissertations

For many years, the United States (U.S.) has been the country with the largest number of immigrants. As a result, policy about immigrant students’ success becomes crucial since it carries not only ethical implications but also economic and societal implications. While there have been other alternatives for students’ success, such as Career and Technical Education (CTE), undeniably, college is still seen as a common pathway to success (e.g., Choi, 2015; Heckman et al., 2018; Turner, 2004). Unfortunately, there are several gaps in the literature on immigrant students’ success and postsecondary outcomes. First, while there is an increasing number of immigrants …

Temporal Trends And Dental Metric Variation In The Macaca Sylvanus Lineage, Cristina Stan

Graduate Theses and Dissertations

The extensive collection of fossil macaques from Europe, spanning from the Late Miocene to the Late Pleistocene period, is believed to be of the species Macaca sylvanus. However, there has been a prolonged discussion regarding the classification of these specimens into a single taxonomic group as the existing dental sample exhibits a large amount of morphological and metric variation. Specifically, researchers have attempted to identify multiple subspecies based on chronological data of the paleontological locality and, secondly, based on dental metric variation. In this study, I assess temporal trends in the fossil record of Macaca sylvanus and compare overall variation …

Two-Photon Quantum Gates With Single Atoms, Arkan Mahmood Hassan

Graduate Theses and Dissertations

In the first part of this dissertation we study in detail the interaction of single-photon and two-photon wavepackets with a three-level V-type atom in a cavity without any control over the interaction time. We solve analytically for the spectrum of the outgoing wavepackets as a function of the incident wavepacket that is valid in all the cavity limits. We consider the potential performance of this system as a CPHASE gate by considering several special input pulses. We optimize for the gate fidelity and find values of the cavity, atomic and pulse parameters that yield a conditional phase shift of π, …

Students Willing And Ready To Motivate To Graduate: An Alternative Pathway To Graduation, Laura Lusk

All Dissertations

With the continual decline of high school graduation rates in South Carolina, there is a need for high schools to look at alternative pathways to graduation. Many of the current alternatives offered to students remove them from the high school setting or interactions with the student body. This study focused on an alternative pathway to graduation, Students Willing and Ready to Motivate to Graduate (SWARM), offered at the high school during the regular school day to students in jeopardy of not graduating. This inclusive approach eliminated transportation barriers and access issues. Students attended school regularly, but one to four classes …