Digital Commons Network^™

Differential Roles Of Cyclin–Cdk1 Complexes In Cell Migration And Invasion, Joseph H.R. Hetmanski, Michael J. Jones, Matthew Hartshorn, Patrick T. Caswell, Matthew C. Jones

Peninsula Medical School

We have previously described a central role for CDK1 at the nexus of adhesion signalling and cell cycle progression, demonstrating that CDK1 has a non-canonical role in regulating integrin adhesion complexes and in the migration of cancer cells in 3D interstitial matrix. Here, we show that the CDK1-binding partners cyclinB1 and cyclinA2 also have roles in cell migration and invasion in both cancer and non-transformed cells. CyclinB1 plays a key role in RhoA activation to promote rear retraction in a membrane tension-dependent manner, whereas cyclinA2 has a general role in promoting motility. Knockdown of either cyclin significantly perturbs migration with …

Large B Cell Lymphoma Microenvironment Archetype Profiles, Xubin Li, Kartik Singhal, Qing Deng, Dai Chihara, David Russler-Germain, R Andrew Harkins, Jared Henderson, Kotaro Arita, Atish Kizhakeyil, Ryan Sun, Priya Lakra, Usama Hussein, Jennifer A Foltz, Ashley Wilson, Evelyn Schmidt, Imran Nizamuddin, Tommy Dinh, Akhil Kesaraju, Mark P Hamilton, Carl Allen, Maher K Gandhi, Joshua Tobin, Aixiang Jiang, Laura Hilton, David W Scott, Francisco Vega, Christopher R Flowers, Jason R Westin, Obi L Griffith, Todd A Fehniger, Malachi Griffith, Michael R Green

Faculty, Staff and Student Publications

Large B cell lymphomas (LBCL) are clinically and biologically heterogeneous lymphoid malignancies with complex microenvironments that are central to disease etiology. Here we have employed single-nucleus multiome profiling of 232 tumor and control biopsies to characterize diverse cell types and subsets that are present in LBCL tumors, effectively capturing the lymphoid, myeloid, and non-hematopoietic cell compartments. Cell subsets co-occurred in stereotypical Lymphoma Microenvironment Archetype Profiles (LymphoMAPs) defined by; (i) a sparsity of T cells and high frequencies of cancer-associated fibroblasts and tumor-associated macrophages [FMAC]; (ii) lymph node architectural cell types with naïve and memory T cells [LN]; or (iii) activated …

Participant Empowerment, Inclusivity, And Social Justice: A Review Of Meng Tian’S Arts-Based Research Methods For Educational Researchers, Niway Ayalew Adimasu

The Qualitative Report

In reviewing Arts-Based Research Methods for Educational Researchers by Meng Tian (2023), I found a priceless resource for contemporary scholars wishing to add cutting-edge arts-based techniques to their qualitative research inquiries. This book offers a thorough examination of how artistic mediums like poetry, theater, and visual arts can be used to investigate the emotional, psychological, and cultural aspects of education that conventional research frequently ignores. It does this by fusing theoretical understanding with helpful advice. The book focuses on participant empowerment, inclusivity, and ethical considerations when working with vulnerable populations highlights the book’s commitment to social justice, making it especially …

Ai In Higher Education: Balancing Innovation And Ethical Challenges.Pdf, Takahiro Fujimoto, Nelson Zee Yang Wong, Siti Aishah Berhan

Jesselton Journal of Educators and Scholars

This study examines the integration of Artificial Intelligence (AI) in higher education, focusing on both its transformative potential and the challenges it introduces for teaching, learning, and institutional operations. As AI technologies such as machine learning, natural language processing, and data analytics become more prevalent, they offer opportunities to personalize learning, enhance administrative efficiency, and support student success. However, the adoption of AI also presents significant barriers, including technological limitations, faculty resistance, ethical concerns, and disparities in access among students and institutions. Using a qualitative research approach and thematic analysis, this research explores the perspectives of administrators, faculty, and students …

Workforce Resilience And Staff Retention Strategies At The Front Of House (Foh) Department: A Case Study Of Ascott Hotel Kuala Lumpur.Pdf, Hanley Chew, Jamalludin Helmi Hashim, Sie Ling Tan

Jesselton Journal of Educators and Scholars

The hospitality industry faces significant challenges in workforce resilience and staff retention, particularly in the Front of House (FOH) department, where high employee turnover can impact service quality and operational efficiency. The research offers detailed insight into workforce resilience along with staff retention strategies at the FOH department highlighting Ascott Hotel Kuala Lumpur. An overview of the Hospitality Industry has been provided for a better understanding of the topic. It also includes various research techniques along with methods considering ethical norms and rules. This study illustrates the potential of Ascott Hotel’s employees in developing workforce resilience and staff retention strategies. …

Innovation And Risk Management In High-Risk Medical Device Development_ Lessons From Japanese Venture Companies.Docx.Pdf, Seiya Shimanuki, Motohiro Kita, Desmond Cherng En Lee, Ahmad Massu Ramli

Jesselton Journal of Educators and Scholars

This article investigates the unique challenges and strategic responses associated with developing high-risk medical devices, emphasizing insights from the Japanese medical technology sector. Utilizing a comprehensive case study of Sun Medical Technology Institute, the research highlights critical strategies, including technological diversity management, simplification of device structures, adoption of low-tech solutions, and leveraging strategic external collaborations to mitigate developmental risks and resource constraints. Additionally, the study explores regulatory complexities, underscoring the importance of proactive compliance strategies in navigating stringent regulatory frameworks effectively. By integrating quantitative patent data analyses, including Lorenz curves and Gini coefficients, the findings reveal the significant impact of …

Adapting To Local Consumer Behaviour And Competitive Pressures: A Case Study Of Digital Transformation In Retail.Pdf, Ge Yan, Louis Yuk Su Chin, Changh Hao Han

Jesselton Journal of Educators and Scholars

This study examines how a multinational retail company adapted to the competitive pressures and local consumer behaviors in the Chinese market through digital transformation. By integrating e-commerce platforms, mobile payment systems, and personalized digital marketing, the company enhanced consumer engagement, optimized operational efficiency, and built a localized brand presence. The case study method draws on both primary data from internal surveys and financial reports and secondary data from reputable industry sources. Key findings reveal a substantial increase in customer satisfaction, higher adoption of mobile payment systems in urban areas, and improved inventory management through predictive analytics. The company’s omnichannel strategy, …

Empowering Leadership, Organizational Culture, And Lecturer Innovativeness In Malaysian Universities_ The Moderating Role Of Psychological Capital.Pdf, Shu Ya Guo, Fung Lan Yong

Jesselton Journal of Educators and Scholars

This study investigates the impact of empowering leadership and organizational culture on lecturer innovativeness in Malaysian universities, emphasizing the moderating role of psychological capital. Utilizing a comprehensive theoretical framework that integrates leadership, organizational behavior, and positive psychology theories, the research explores how leadership practices and cultural factors within educational institutions contribute to innovation among lecturers. Data were collected through surveys and analyzed using statistical methods, revealing that both empowering leadership and a supportive organizational culture significantly enhance lecturer innovativeness. Furthermore, psychological capital, encompassing self-efficacy, optimism, hope, and resilience, was found to positively moderate the relationship between leadership, culture, and innovativeness. …

Development And Usability Testing Of A Preliminary Web-Based Application For The Clinical Implementation Of Blood Flow Restriction: A Mixed Methods Pilot Study, Isaac J. Wedig, Erich Petushek, John J. Durocher, John Mcdaniel, Steven J. Elmer

Michigan Tech Publications

Introduction: Exercise with blood flow restriction (BFR) has gained popularity for use with a wide range of healthy and clinical populations. However, several factors including medical screening, selection of equipment, and determination of cuff pressure still pose barriers for implementation. Accordingly, this study aimed to develop and test a web-based application to guide practitioners in using BFR safely and effectively. Methods: First, we developed an application to assist with medical screening, selection of appropriate equipment, and determination of cuff pressures. Subsequently, we conducted preliminary usability testing of the application using a mixed methods approach. Licensed physical therapists (n = 5) …

The Feasibility Of Passively Tracking Children’S Tv Viewing And Mobile Device Use In Naturalistic Settings, Anil Kumar Vadathya, Jennette P Moreno, Alicia Beltran, Samah Haidar, Nimah Haidar, Sheryl O Hughes, Debbe Thompson, Salma M A Musaad, Tom Baranowski, Jason A Mendoza, Joseph Young, Akane Sano, Ashok Veeraraghavan

Faculty, Staff and Students Publications

Research on children's technology and digital media (TDM) is hampered by a lack of robust approaches for assessing TDM use. This study assessed the feasibility of passively measuring children's TV screens and mobile devices (TDM) in a naturalistic setting. In the three-day feasibility study, FLASH-TV was set up on one to two TVs the child (5-12 year olds) typically used in the home (n=20). Children's mobile device use was assessed with either the Chronicle App or ScreenTime screenshots. Parents completed three TDM diaries. An exit interview with the parent explored their perceptions of the assessments and the child's TDM use …

Parental Attitudes To Risky Play And Children’S Independent Mobility: Public Health Implications For Children In Ireland, Fiona Armstrong, Michael Joseph Barrett, David Gaul, Lorraine D’Arcy

Research Outputs: 2025-Present

Background: Understanding the determinants of children’s outdoor play is an important element for child development and broader public health outcomes. There is growing evidence that children’s opportunities for play, particularly outdoor risky play, are diminishing. Parents are concerned with keeping their child safe while affording them independence to play. This study explored parents’ attitudes to risky play and practices around children’s independent mobility in Ireland with the aim of informing public health strategies promoting healthy childhood environments. Methods: An online survey comprising validated scales and standardised questions was completed by a nationally represented sample of 376 parents of children up …

Navigating The Employability Landscape: Unanswered Questions For International Students In Southeast Asia, Hengzhi Hu

Higher Learning Research Communications

As Southeast Asia becomes an increasingly popular destination for international students, important questions arise concerning the employability of graduates from this region. This comment article advocates for a comprehensive examination of how effectively Southeast Asian universities equip their international students to navigate both global and home country labor markets. Additionally, this article calls for a critical rethinking of the global recognition and value of qualifications obtained from Southeast Asian higher education providers, which often face challenges in being perceived as on par with those from more established educational hubs and underscores the necessity for comparative research to assess how the …

Integrating Belowground Recovery Into Tropical Forest Restoration Design And Monitoring, Lauren Toro, Leland K. Werden, Shalom D. Addo-Danso, Kelly M. Andersen, Sarah Batterman, Matilde M. Bragadini, Pooja Choksi, Rebecca J. Cole, Liza S. Comita, Daniela Cusack, Daisy H. Dent, Lee H. Dietterich, Joshua B. Fisher, Katrin Fleischer, Lucia Fuchslueger, Nohemi Huanca-Nunez, Janey R. Lienau, Lindsay A. Mcculloch, Ember M. Morrissey, Jennifer S. Powers, Mareli Sánchez-Juliá, Oscar Valverde-Barrantes, Anita Weissflog, Michelle Y. Wong

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

There is growing recognition that tropical forest restoration is key for sequestering carbon and enhancing ecosystem resilience. Soils, roots, and soil biota are central to ecosystem function and services, but belowground recovery is largely overlooked in restoration monitoring frameworks. Here, we outline current understanding of the links between above- and belowground recovery in tropical forests by examining how belowground properties before and after intervention influence recovery; by evaluating whether aboveground recovery can serve as a proxy for belowground dynamics; and by proposing a blueprint for monitoring dynamic soil physical (bulk density, aggregate stability), chemical (organic matter or carbon, pH), and …

Boricua En La Luna: An Ethnographic Case Study On The Spatializations Of Puerto Ricans In New Mexico, Neritza Díaz Cruz

Language, Literacy, and Sociocultural Studies ETDs

This ethnographic case study investigates the spatializations of Puerto Ricans in New Mexico, a state where the community is small, dispersed, and often invisible. The purpose of this study is to examine how Puerto Rican identity is shaped, expressed, and contested across New Mexican spaces. Drawing from critical spatial theory, this study investigates how broader structures such as language ideologies become spatialized in the everyday lives of five Puerto Rican adults living in the Albuquerque area. Data was gathered through interviews, observations, and participatory mapping. Thematic analysis was used to interpret the data with a focus on how lived, perceived, …

"Chatgpt Told Me To Say It": Ai Chatbots And Class Participation Apprehension In University Students, Daisuke Akiba

Publications and Research

The growing prevalence of AI chatbots in everyday life has prompted educators to explore their potential applications in promoting student success, including support for classroom engagement and communication. This exploratory study emerged from semester-long observations of class participation apprehensions in an introductory educational psychology course, examining how chatbots might scaffold students toward active and independent classroom contribution. Four students experiencing situational participation anxiety voluntarily participated in a pilot intervention using AI chatbots as virtual peer partners. Following comprehensive training in AI use and prompt design given to the entire class, participants employed systematic consultation frameworks for managing classroom discourse trepidations. …

Ndls Communicator: Week Of 07.14.25, Notre Dame Law School

NDLS Communicator

The Latest News

• Notre Dame Law School Professors Sadie Blanchard and Sherif Girgis granted tenure and promoted to full professor
• Experts from across the world convene at fifth annual Notre Dame Religious Liberty Summit

Faculty Briefs

• Bob Jones
• Jay Tidmarsh
• Lloyd Mayer
• Fr. John Paul Kimes
• Derek Muller
• Rick Garnett
• Judy Fox
• Christian Burset
• Diane Desierto
• Kari Gallagher
• Mary Ellen O'Connell
• David McIlroy
• Satvinder Juss
• Jorge Barrera-Rojas

Student & Alumni News

• John F. Crowley, J.D. '89, was elected to serve on the University of Notre Dame's Board of Trustees.
• Joshua Dunlap, J.D. '08, was nominated by President Donald Trump to …

Silent Threats: Awareness And Attitudes To Communication Of Sudep Among Neurologists In India: A Cross-Sectional Study, Rohit Shankar

Peninsula Medical School

Background: International guidelines unequivocally endorse the importance and need to discuss Sudden Unexpected Death in Epilepsy (SUDEP) with people with epilepsy (PWE). India is a country accounting for a sixth of all global epilepsy burden. Despite this little is known of Indian neurologists’ knowledge and attitudes to SUDEP. Objective: To explore India Neurologists awareness and attitudes to SUDEP communication to PWE. Methods: A cross-sectional online survey of Likert response questions using validated themes, was circulated among the neurology fraternity, India. Non-discriminatory exponential snowballing technique leading to convenience non-probability sampling was used. The inquiry involved SUDEP-related topics including the awareness, knowledge, …

Centering And Shaping Abilities Of Three Different Cross-Section Rotary Systems In Curved Canals Using Cbct, Muhammed Ahmed Omar Abouel Seoud Phd, Maha Nassar

Dentistry

he aim of the study was to examine the centering and shaping abilities of the E3 Azure,T Blue and XPRS rotary devices in severely curved root canals utilizing CBCT. 51 mesial rootswere used in this study, then distributed into three groups of 17 mesial canals each according to theinstrumentation technique: T-Blue, E3 Azure and XPS. The final apical size of instrumentation was30/0.04 for all groups. At 2 mm, all pairwise comparisons were statistically significant, with Azureshowing the highest transportation, followed by T-Blue, and XPS showing the least (p< 0.001). At 4mm and 6 mm, Azure and T-Blue showed significantly higher transportation than XPS (p< 0.001).For XP-Shaper files, centering ratios followed a descending order from 6 mm to 4 mm and werelowest at 2 mm, with all pairwise comparisons being statistically significant (p< 0.001). it wasconcluded that XPS show lesser transportation and better centering ability (PDF) Centering and Shaping abilities of three different cross-section rotary systems in …