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Articles 43561 - 43590 of 1738852
Full-Text Articles in Entire DC Network
Full Issue, Iajbs Ateneo De Manila University
Full Issue, Iajbs Ateneo De Manila University
Journal of Management for Global Sustainability
No abstract provided.
Gestionar Para La Sostenibilidad Global, Maria Assunta C. Cuyegkeng
Gestionar Para La Sostenibilidad Global, Maria Assunta C. Cuyegkeng
Journal of Management for Global Sustainability
No abstract provided.
Circumciser Type And The Type Of Female Genital Mutilation/Cutting Prevalence For Girls Ages 0-14 Years In Ethiopia, Jean-Pierre Ramazani Abedi
Circumciser Type And The Type Of Female Genital Mutilation/Cutting Prevalence For Girls Ages 0-14 Years In Ethiopia, Jean-Pierre Ramazani Abedi
Walden Dissertations and Doctoral Studies
Despite ongoing eradication efforts, female genital mutilation and cutting (FGM/C) remains a major public health and human rights concern in Ethiopia. This quantitative study was conducted to examine how circumciser type (traditional cutter, birth attendant, or health professional) influences FGM/C prevalence and severity among girls ages 0–14, considering the moderating effects of residence and mothers’ FGM status, while controlling for age and income. Guided by the social ecological model and using 2016 E Ethiopian Demographic Health Surveys data, analysis indicates a significant association between circumciser type and FGM/C type (χ² (2, N = 1,553) = 6.86, p = .032), which …
Teachers’ Experiences With The Use Of Read-Alouds For Fourth- And Fifth-Grade Students, Shervita Bryant
Teachers’ Experiences With The Use Of Read-Alouds For Fourth- And Fifth-Grade Students, Shervita Bryant
Walden Dissertations and Doctoral Studies
The research problem addressed in this basic qualitative study was the inconsistent use and implementation of teacher read-alouds among fourth- and fifth-grade teachers in an urban district. Guided by Clark and Peterson’s cognitive process teacher model, Rumelhart’s schema theory, and Gough and Tunmer’s simple view of reading, the purpose of this project study was to explore teachers’ experiences and perceptions regarding their use of read-alouds as part of their regular reading instruction. Two research questions were developed to explore teachers’ experiences of the support received for using the read-aloud. Semistructured interviews were conducted with 10 fourth- and fifth-grade teachers. Data …
Datamut: Deterministic Algorithms For Time-Delay Attack Detection In Multi-Hop Uav Networks, Keiwan Soltani, Federico Corò, Punyasha Chatterjee, Sajal K. Das
Datamut: Deterministic Algorithms For Time-Delay Attack Detection In Multi-Hop Uav Networks, Keiwan Soltani, Federico Corò, Punyasha Chatterjee, Sajal K. Das
Computer Science Faculty Research & Creative Works
Unmanned Aerial Vehicles (UAVs), also known as drones, have gained popularity in various fields such as agriculture, emergency response, and search and rescue operations. UAV networks are susceptible to potential security threats, such as wormhole attacks, jamming, spoofing, and false data injection. Time-Delay Attack (TDA) is a unique attack in which malicious UAVs intentionally delay packet forwarding, posing significant threats, especially in time-sensitive applications. It is challenging to distinguish malicious delay from benign network delay due to the dynamic nature of UAV networks, intermittent wireless connectivity, or the Store-Carry-Forward (SCF) mechanism during multi-hop communication. Some existing works propose machine learning-based …
Enhanced Superconductivity And Vortex Dynamics In Quasi-1d Tas2 Nanowires, Mathew Pollard, Visakha Ho, Clarissa Wisner, Eric W. Bohannan, Yew San Hor
Enhanced Superconductivity And Vortex Dynamics In Quasi-1d Tas2 Nanowires, Mathew Pollard, Visakha Ho, Clarissa Wisner, Eric W. Bohannan, Yew San Hor
Chemistry Faculty Research & Creative Works
We report the synthesis of high-quality 2H-TaS2 nanowires via a controlled two-step conversion process from TaS3 precursors, achieving robust superconductivity with a transition temperature T c ≈ 3.6K, which is significantly higher than bulk 2H-TaS2 (T c ≈ 0.8K). Structural and compositional analyses confirm phase purity and preserved one-dimensional morphology, while magneto transport measurements reveal an enhanced upper critical field μ 0 H c2 (2K)≈5 T, far exceeding the bulk value (μ0Hc2 (0)≈1.17T), attributed to dimensional confinement and suppression of charge-density wave order. Magnetic characterization demonstrates complex vortex dynamics, including flux jumps and a …
Community Engagement And Experiential Learning To Understand Food Insecurity In Georgia’S Urban Environments, Gregory Gullette, Jenna Andrews-Swann, Nicole Villamil, Christin Cain
Community Engagement And Experiential Learning To Understand Food Insecurity In Georgia’S Urban Environments, Gregory Gullette, Jenna Andrews-Swann, Nicole Villamil, Christin Cain
Southern Anthropologist
No abstract provided.
Ga2o3 Tcad Mobility Parameter Calibration Using Simulation Augmented Machine Learning With Physics-Informed Neural Network, Edric Khai Jieh Ong, Le Minh Long Nguyen, Matthew Eng, Yuhao Zhang, Hiu Yung Wong
Ga2o3 Tcad Mobility Parameter Calibration Using Simulation Augmented Machine Learning With Physics-Informed Neural Network, Edric Khai Jieh Ong, Le Minh Long Nguyen, Matthew Eng, Yuhao Zhang, Hiu Yung Wong
Faculty Research, Scholarly, and Creative Activity
In this article, we demonstrate the feasibility of performing automatic technology computer-aideddesign (TCAD) parameter calibration and extraction using machine learning (ML), with the machine trained solely by TCAD-simulation data. The methodology is validated using experimental data. Schottky barrier diodes (SBDs) with different effective anode workfunctions (WF) are fabricated with emerging ultrawide bandgap material, Gallium Oxide (Ga2O3), and are measured at various temperatures (T). Their current-voltage (I–V) curves are used for automatic Ga2O3 Philips unified mobility (PhuMob) model parameters calibration. Five critical PhuMob parameters (µmax, µmin, Nref, α, and θ) were calibrated. The machine consists of an autoencoder (AE) and a …
Tampa Bay Mycobiome, Alyssa L. Fischer, Yanori M. Ferguson, Ojas Natarajan, Larry J. Dishaw
Tampa Bay Mycobiome, Alyssa L. Fischer, Yanori M. Ferguson, Ojas Natarajan, Larry J. Dishaw
Making Waves REU
The marine mycobiome is a largely unexplored area of research despite its importance to the environment as a carbon sink, nutrient manager, and as a symbiont of various marine life. With rising temperatures, there is a need to identify the fungi present in these environments to monitor changes in biodiversity and their effect on climate change. Along Tampa Bay, six sites were chosen to collect samples from surface water using a CTD rosette system. The collected water was filtered, and DNA was extracted in order to classify and catalog species of both bacteria and fungi through 16S and ITS sequencing, …
Perceptions Of Juvenile Justice Professionals Regarding The Effectiveness Of Juvenile Reentry Programs And Recidivism In The Southwest Region, Lei Anne Johnson
Perceptions Of Juvenile Justice Professionals Regarding The Effectiveness Of Juvenile Reentry Programs And Recidivism In The Southwest Region, Lei Anne Johnson
Walden Dissertations and Doctoral Studies
Juvenile recidivism persists in the U.S. justice system, highlighting the need for effective reentry programs. However, limited research exists on juvenile justice professionals’ perceptions of program success. The purpose of this qualitative study was to explore these professionals’ perceptions regarding the effectiveness of juvenile reentry programs in reducing recidivism. Guided by Bandura’s social learning theory, the study examined how observation and modeling influence youth behavior during reentry. The research questions focused on professionals’ perceptions of program effectiveness and how these perceptions impact recidivism reduction efforts. A qualitative phenomenological design involved semi-structured interviews with 13 juvenile justice professionals in the southwest …
Multi-Omics Comparison Of Two Emerging Storage Pests (Necrobia Rufipes And Tribolium Castaneum) Of Dried Black Soldier Fly Larvae Product, Inusa Jacob Ajene, Chrysantus M. Tanga, Komivi S. Akutse, Samantha W. Karanu, Fathiya M. Khamis
Multi-Omics Comparison Of Two Emerging Storage Pests (Necrobia Rufipes And Tribolium Castaneum) Of Dried Black Soldier Fly Larvae Product, Inusa Jacob Ajene, Chrysantus M. Tanga, Komivi S. Akutse, Samantha W. Karanu, Fathiya M. Khamis
All Peer-Reviewed Publications
The black soldier fly (BSF) larvae is a rich and promising source of alternative protein that continues to increasingly gain global traction as a functional ingredient for sustainable livestock and fish production. The key setback to postharvest processing of stored BSF larvae (BSFL) products is the significant damage caused by two notable storage pests (Tribolium castaneum and Necrobia rufipes). Here, we present a comparative analysis of the complete mitochondrial genomes and gut microbiome profiles of T. castaneum and N. rufipes. The study mitogenomes were similar in size and structure to other coleopteran mitogenomes. The gut microbiome profiles of the two …
Volume 35, Issue 1: Contents
Washington International Law Journal
No abstract provided.
Allocating Data Protection Duties The Chinese Way
Allocating Data Protection Duties The Chinese Way
Washington International Law Journal
Abstract: China has been enacting data protection laws with distinctive features at an unprecedented pace, which makes it necessary to update existing studies on the Chinese approach to data protection. Unlike its predecessors, this Article focuses on developing a structured approach to dissecting the Chinese regime, especially the Personal Information Protection Law and latest case law. It analyzes how the laws allocate responsibilities among the three major parties involved in data protection—individual data subjects, data controllers, and regulators—and draws comparisons with European Union (EU) laws that inspired the Chinese laws. It argues that the way Chinese laws allocate data …
The Stripes Of Glory We Wear: Reflections Of The Legal Role And Intricacies Of Citizenship In The History And Foundation Of The Malaysian State
Washington International Law Journal
Abstract: The meaning of citizenship in Malaysia is a tale as old as the country itself—a thorny triangular relationship between the state; the Bumiputera majority of Malay and indigenous natives; and the non-Bumiputeras minority of Chinese and Indians who primarily migrated when the region was under British colonial rule and influence. In the present, Bumiputeras enjoy a constitutionally stipulated special status—a distinction that bestows many privileges and preferential treatment in all facets of life, from commerce to education, homeownership to government employment, that is off-limits to non-Bumiputeras. Supporters of the system argue it remains necessary—a form of affirmative action …
The Taiwanese Way To Ai Governance: Draft Basic Law On Artificial Intelligence And Future Regulatory Strategies
Washington International Law Journal
Abstract: Despite Taiwan’s significant contributions to the global artificial intelligence (AI) ecosystem, its role remains underexamined in international AI governance discourse. This Article addresses this gap by analyzing Taiwan’s emerging AI regulatory framework, with particular emphasis on the Draft Basic Law on Artificial Intelligence (the “Draft AI Law”). Situating Taiwan’s approach within the broader global regulatory landscape, the Article compares the Draft AI Law with key international models, including the European Union’s AI Act and the United States’ NIST AI Risk Management Framework, while also drawing on regulatory developments in Japan and South Korea. Rather than providing a clause-by-clause analysis, …
Litigating Workplace Sexual Harassment In China: Practical Challenges & Proposed Solutions
Litigating Workplace Sexual Harassment In China: Practical Challenges & Proposed Solutions
Washington International Law Journal
Abstract: The development of China’s anti-sexual harassment laws and policies over the past few decades has raised the hopes of many. However, the sheer volume of regulations can easily create the false impression that the Chinese legal system is effectively dealing with workplace sexual harassment. Statistics show that the number of lawsuits filed in Chinese courts remains trivial, even though workplace sexual harassment continues to be widespread. This article argues that courts in China misunderstand how to apply important concepts in litigation such as how to define sexual harassment and employer liability. The difficulty of carrying the burden of …
Pciafl: Personalized And Class Imbalance-Aware Federated Learning For Driver Behavior Classification, Osho Osho, Shubh Garg, Suchetana Chakraborty, Sajal K. Das
Pciafl: Personalized And Class Imbalance-Aware Federated Learning For Driver Behavior Classification, Osho Osho, Shubh Garg, Suchetana Chakraborty, Sajal K. Das
Computer Science Faculty Research & Creative Works
Automated understanding of driver behavior from vehicular kinematics is vital for safety-aware intelligent transportation systems. However, centralized cloud processing suffers from latency, scalability, and privacy issues. Federated Learning (FL) provides a decentralized alternative but faces two major challenges: (i) non-IID client data due to heterogeneous driving styles and sensors, and (ii) severe class imbalance, as risky behaviors are inherently rare. In this work, we propose a personalized FL framework that uses a shared CNN-LSTM backbone with client-adaptive classifiers and incorporates a cost-sensitive loss to address behavior skew. Evaluated on the UAH-DriveSet dataset, our method achieves 92.60% accuracy and 91.68% macro-F1, …
The Long Goodbye Of The History Of Economic Thought Course In Liberal Arts Colleges In The United States, Humberto Barreto
The Long Goodbye Of The History Of Economic Thought Course In Liberal Arts Colleges In The United States, Humberto Barreto
School of Business and Leadership Working Papers
Economists of a certain age will remember a world in which the history of economic thought (HET) was alive and flourishing. Today, that is not the case. One little-noticed consequence of the elimination of HET from graduate programs in the United States is that the HET course is an endangered species at the undergraduate level. It is not, however, extinct. This paper offers a brief history of HET as a course and explores the extent of the diminution in HET courses in the undergraduate liberal arts college curriculum in the United States. Roughly 40% of 146 schools have a HET …
From Local To Global: Surabaya’S Paradiplomacy Strategy In Realising A Child-Friendly City, Muhammad Fajhriyadi Hastira, Ali Maksum, Muh Fichriyadi Hastira, Ramalina Ranaivo Mikea Manitra
From Local To Global: Surabaya’S Paradiplomacy Strategy In Realising A Child-Friendly City, Muhammad Fajhriyadi Hastira, Ali Maksum, Muh Fichriyadi Hastira, Ramalina Ranaivo Mikea Manitra
Global: Jurnal Politik Internasional
Along with the development of decentralisation and subnational diplomacy, strengthening child protection at the city level has become an important part of the global agenda. This research aims to analyse the implementation of the Child-Friendly Cities Initiative in Surabaya City from a paradiplomacy perspective. In addition, this study seeks to explain the synergy between local, national, and global policies and identify opportunities and challenges using literature studies and analysis of official documents from the Ministry of Women's Empowerment and Child Protection (PPPA) and the Surabaya Office of Women's Empowerment, Child Protection, Population Control, and Family Planning (P3APPKB), the Surabaya City …
Does Adding An Interbody Cage In L4–L5 Posterolateral Fusion For Degenerative Spondylolisthesis And Stenosis Improve Clinical Outcome?, Enrico Aimar, Lucrezia Di Stefano, Federico Longhitano, Alberto Bona, Marco Meloni, Tommaso Alfiero, Federica Valente, Roberta Bonomo, Giulio Bonomo, Flavio Tancioni, Guglielmo Iess
Does Adding An Interbody Cage In L4–L5 Posterolateral Fusion For Degenerative Spondylolisthesis And Stenosis Improve Clinical Outcome?, Enrico Aimar, Lucrezia Di Stefano, Federico Longhitano, Alberto Bona, Marco Meloni, Tommaso Alfiero, Federica Valente, Roberta Bonomo, Giulio Bonomo, Flavio Tancioni, Guglielmo Iess
Department of Neurosurgery Faculty Papers
INTRODUCTION: As the population ages, L4-L5 degenerative spondylolisthesis is increasingly common. Posterolateral fusion was long standard; interbody cages are widely used for perceived higher fusion rates.
RESEARCH QUESTION: Does adding an interbody cage to posterolateral fusion improve outcomes or reduce complications in elderly patients with grade I spondylolisthesis and severe stenosis?
MATERIALS AND METHODS: We retrospectively studied 319 adults aged 60-85 who underwent single-level L4-L5 fusion (2011-2018) after failed conservative care. Patients received posterior lumbar fusion (PLIF, n = 155) or posterolateral lumbar fusion (PLF, n = 164). Primary outcomes were Oswestry Disability Index (ODI) change and complications over a …
Aspects Of Board Diversity And Audit Fees: Evidence From An Emerging Economy, Aref M. Eissa, Yasser Eliwa, Ahmed Diab
Aspects Of Board Diversity And Audit Fees: Evidence From An Emerging Economy, Aref M. Eissa, Yasser Eliwa, Ahmed Diab
All Works
This study examines the impact of board diversity by gender and nationality on audit fees. It also assesses how board diversity moderates the relationship between corporate financial risk and audit fees in the context of recent governance changes in Egypt, as a developing country. Using a sample of 360 firm-year observations of non-financial firms listed on the EGX100 from 2014 to 2019, we conduct univariate and multivariate analyses to examine the impact of board diversity on audit fees after controlling for firm and audit committee characteristics. Our results indicate a significant positive effect of corporate boards’ gender and national diversity …
Powering Up Clinical Scholarship In Urology, Evelyn Wang
Powering Up Clinical Scholarship In Urology, Evelyn Wang
HSLIC Faculty and Staff Instructional Resources
This presentation introduces core concepts of clinical scholarship for urology residents and faculty, with a focus on turning clinical questions into structured literature searches and using HSLIC resources to support small-scale scholarly projects. Key topics include framing answerable clinical questions (e.g., PICOT), navigating core clinical information tools (PubMed, EMBASE, CINAHL, ClinicalKey, UpToDate, HSLIC LibGuides), applying practical literature search techniques (Boolean operators, truncation, wildcards, proximity operators, subject headings), documenting basic search strategies, accessing full text (LibKey Nomad, proxy authentication, interlibrary loan and document delivery), and an introductory overview of critical appraisal tools and publishing supports available through HSLIC.
Optimizing Proaftn Classifier With Ant Colony Algorithm: Enhanced Diabetes Detection Benchmarking, Feras Al-Obeidat
Optimizing Proaftn Classifier With Ant Colony Algorithm: Enhanced Diabetes Detection Benchmarking, Feras Al-Obeidat
All Works
The increasing global prevalence of diabetes highlights the need for accurate diagnostic tools to improve early detection and effective treatment planning. Traditional classification models often struggle to achieve optimal performance due to limitations in parameter tuning and adaptability to complex datasets. To address these limitations, this article introduces PROAnt, an innovative learning approach designed to enhance the robustness and efficiency of the PROAFTN multicriteria classification method. PROAnt leverages the computational power of ant colony optimization (ACO) to dynamically fine-tune and optimize the key parameters, such as intervals and weights, at the core of the PROAFTN classification process. This learning methodology …
A Systematic Literature Review Of Cvid Reveals Pervasive Detrimental Noninfectious Manifestations, G Michelle Ducasa, Rebecca A Marsh, Ali Mojebi, Hsi-En Ho, Charlotte Cunningham-Rundles, Lisa Forbes Satter, Elena W Y Hsieh, Sinisa Savic, Marta Dafne Cabañero-Navalón, Hector Balastegui-Martin, Joud Hajjar, Gulbu Uzel, Kevin S Thorneloe, Jocelyn R Farmer
A Systematic Literature Review Of Cvid Reveals Pervasive Detrimental Noninfectious Manifestations, G Michelle Ducasa, Rebecca A Marsh, Ali Mojebi, Hsi-En Ho, Charlotte Cunningham-Rundles, Lisa Forbes Satter, Elena W Y Hsieh, Sinisa Savic, Marta Dafne Cabañero-Navalón, Hector Balastegui-Martin, Joud Hajjar, Gulbu Uzel, Kevin S Thorneloe, Jocelyn R Farmer
Faculty, Staff and Students Publications
Noninfectious manifestations of common variable immunodeficiency (CVID) are not formally summarized. We performed a systematic literature review to generate a comprehensive reference for the field. Splenomegaly was the most reported manifestation across 53 publications, occurring in a median of 35.2% of patients. Frequently reported digestive system manifestations included diarrhea (median 27.8%; 21 publications), hepato(spleno)megaly (median, 21.0%; 19 publications), portal hypertension (median 21.0%; 3 publications), nodular lymphoid hyperplasia (median, 17.0%; 9 publications), and enteropathy (median, 16.0%; 34 publications). Other notable manifestations included interstitial lung disease (median, 8.7%; 32 publications) and autoimmune cytopenias (median 18.0%; 21 publications). Steroids and rituximab were the …
Neurodevelopmental Outcomes Following Hematopoietic Cell Transplantation For Patients With Severe Combined Immunodeficiency (Scid): A Pidtc Study, Virdette L Brumm, Sharon A Kidd, Brent R Logan, Farheen Chunara, Jennifer Heimall, Linda M Griffith, Donald B Kohn, Lauren Sanchez, Jeffrey J Bednarski, Caridad Martinez, Mark Vander Lugt, Neena Kapoor, Nicola Wright, Barbara Spitzer, Joseph H Oved, Sharat Chandra, Deepak Chellapandian, Christen L Ebens, Aleks Petrovic, Ahmad Rayes, Hilary L Haines, Hannah Lust, Hannah-Lise Tirado Schofield, Lauren Christopher, Lynnette L Harris, Lisa Forbes Satter, Lauri Burroughs, Christopher C Dvorak, Elie Haddad, Jennifer W Leiding, Rebecca A Marsh, Luigi D Notarangelo, Sung Yun Pai, Michael A Pulsipher, Jennifer M Puck, Morton J Cowan, Ami J Shah
Neurodevelopmental Outcomes Following Hematopoietic Cell Transplantation For Patients With Severe Combined Immunodeficiency (Scid): A Pidtc Study, Virdette L Brumm, Sharon A Kidd, Brent R Logan, Farheen Chunara, Jennifer Heimall, Linda M Griffith, Donald B Kohn, Lauren Sanchez, Jeffrey J Bednarski, Caridad Martinez, Mark Vander Lugt, Neena Kapoor, Nicola Wright, Barbara Spitzer, Joseph H Oved, Sharat Chandra, Deepak Chellapandian, Christen L Ebens, Aleks Petrovic, Ahmad Rayes, Hilary L Haines, Hannah Lust, Hannah-Lise Tirado Schofield, Lauren Christopher, Lynnette L Harris, Lisa Forbes Satter, Lauri Burroughs, Christopher C Dvorak, Elie Haddad, Jennifer W Leiding, Rebecca A Marsh, Luigi D Notarangelo, Sung Yun Pai, Michael A Pulsipher, Jennifer M Puck, Morton J Cowan, Ami J Shah
Faculty, Staff and Students Publications
Hematopoietic cell transplantation (HCT) is a potentially curative treatment for severe combined immunodeficiency (SCID). Since the initiation of newborn screening (NBS), survival rates have improved significantly, but the impact of HCT upon neurodevelopment for patients with SCID requires more investigation. We performed a cross-sectional study of subjects with SCID in North America to assess the impact of NBS, transplant conditioning regimen, and genotype on neurodevelopmental outcomes after HCT. 69 subjects with SCID from 17 PIDTC centers (excluding those with ADA deficiency), ages 6-16 years, received comprehensive standardized neurodevelopmental testing of cognitive, behavioral, and emotional function. Compared with the normative population, …
Performance Of A Rapid, Highly Multiplexed Nucleic Acid Detection Assay For Identification Of Viral And Bacterial Pathogens From Upper Respiratory Tract Specimens, Coreen L Johnson, James J Dunn
Performance Of A Rapid, Highly Multiplexed Nucleic Acid Detection Assay For Identification Of Viral And Bacterial Pathogens From Upper Respiratory Tract Specimens, Coreen L Johnson, James J Dunn
Faculty, Staff and Students Publications
Background: Accurate and timely identification of upper respiratory tract pathogens can improve patient management by decreasing unnecessary additional testing, reducing the cost of care, and informing antimicrobial stewardship. We evaluated the FDA-cleared Diasorin LIAISON PLEX® Respiratory Flex (RSP Flex), a highly multiplexed, rapid nucleic acid detection assay that can identify 14 viral and 5 bacterial respiratory pathogens.
Methods: In total, 215 residual patient upper respiratory tract specimens were tested using the RSP Flex assay and results compared to standard-of-care (SOC) molecular testing.
Results: Positive percentage agreement (PPA) was 100% for the following targets: adenovirus, human coronavirus, Bordetella pertussis, Bordetella parapertussis, …
Clinical Performance Of A Novel Point-Of-Care High-Sensitivity Cardiac Troponin I Assay, Alan H B Wu, Stacey L House, Et Al.
Clinical Performance Of A Novel Point-Of-Care High-Sensitivity Cardiac Troponin I Assay, Alan H B Wu, Stacey L House, Et Al.
2020-Current year OA Pubs
BACKGROUND: High-sensitivity cardiac troponin (hs-cTn) assays performed in the central laboratory have long turnaround times. This study evaluates the clinical performance of a novel bedside point-of-care (POC) hs-cTnI assay (i-STAT® hs-TnI) to aid in the diagnosis of myocardial infarction (MI).
METHODS: A prospective multisite cohort study involving emergency department (ED) patients with symptoms suggestive of acute coronary syndrome was conducted at 28 sites across the United States. Serial whole blood samples were collected at 0-1 h and >1-3 h from ED presentation. Primary outcome was MI or non-MI. Sensitivity, specificity, and negative predictive value (NPV) for MI were calculated with …
Β2 And Β3a Regulatory Subunits Can Coassemble In The Same Bk Channels, Yu Zhou, Vivian Gonzalez-Perez, Xiao-Ming Xia, Gopal S Kallure, Sandipan Chowdhury, Christopher J Lingle
Β2 And Β3a Regulatory Subunits Can Coassemble In The Same Bk Channels, Yu Zhou, Vivian Gonzalez-Perez, Xiao-Ming Xia, Gopal S Kallure, Sandipan Chowdhury, Christopher J Lingle
2020-Current year OA Pubs
Ca2+- and voltage-activated BK-type K+ channels are influenced profoundly by associated regulatory subunits, including β subunits (Kcnmb1-4; β1-β4). Although overlap in expression of different BK β subunits occurs in native tissues, whether they can coassemble in the same channel complex is not known. We coexpress β2 and β3a subunits together with BK α and, through a combination of macroscopic and single-channel recordings, along with quantitative pull-down of tagged subunits, test whether coassembly can occur. We evaluate two models: (1) random mixing in which β2 and β3a subunits coassemble in the same channels, and (2) segregation in which β2 and β3a …
Towards A Unified Gating Scheme For The Cnbd Ion Channel Family, Jenna L Lin, Baron Chanda
Towards A Unified Gating Scheme For The Cnbd Ion Channel Family, Jenna L Lin, Baron Chanda
2020-Current year OA Pubs
Cyclic nucleotide-binding domain (CNBD) channels are critical components of numerous bioelectrical processes, including cardiac pacemaking, neuronal signaling, phototransduction in the eye, and stomatal regulation in plants. While members of this channel family share a conserved overall structure, they exhibit striking differences in voltage sensitivity. Hyperpolarization-activated cyclic nucleotide-gated channels are activated by membrane hyperpolarization, whereas ether-à-go-go channels open upon depolarization. Mutagenesis and chimeragenesis studies have revealed that some mutants display bipolar gating behavior-remaining closed at intermediate membrane potentials but capable of opening in response to both hyperpolarization and depolarization. Remarkably, in certain cases, just a few mutations are sufficient to reverse …