Digital Commons Network^™

Religious Higher Education Institutions In Ukraine: The Evolution Of The Problem And The Collision Of The "Secular–Religious" Dichotomy, Serhii Kostiuchkov, Vadym Slyusar, Lesya Chervona, Mykola Slyusar

Occasional Papers on Religion in Eastern Europe

The article is devoted to institutional, legislative, philosophical and communicative analysis of the activities of religious higher education institutions in modern Ukraine, taking into account political, social, legal, religious and communicative contexts. The authors examine the demand for religious education in modern Ukraine, which demonstrates high internal dynamics and promising prospects for the development of the domestic religious educational space. It is emphasised that the functioning of religious higher education institutions in Ukraine is regulated by the principle of constitutional separation of education from religion, while at the same time basic legal norms create specific conditions for the functioning of …

Examining How Continuous Professional Development Shapes Teaching Practice And Student Learning Outcomes, Jane Rarieya, Mary Oluga, Nyagwegwe Wango

Institute for Educational Development, East Africa

Purpose: This study examines how Teacher Continuous Professional Development (TCPD) initiatives implemented through the Strengthening Education Systems in East Africa (SESEA) and Foundation for Learning (F4L) projects influence teaching practices and foundational learning outcomes in Tanzania, Kenya, and Uganda.

Methodology: The study employed a mixed-methods research design using longitudinal data from classroom observations, teacher questionnaires, student assessments, and key informant interviews. Data were collected from trained teachers, teacher educators, school leaders, and learners across selected project regions to evaluate changes in instructional practices and learning outcomes.

Findings: The findings indicate that TCPD significantly improved teachers’ adoption of child-centered, play-based, inclusive, …

Immersive Experience Design In Contemporary Theme Parks: A Case Study Of Universal Epic Universe, Roi Andre F. Ramos

Experience Industry Management

The evolution of contemporary theme parks has increasingly centered on large-scale immersive environments designed to transport guests into cohesive narrative worlds. The purpose of this study was to examine the immersive design practices utilized at Universal Epic Universe. A case study was conducted to evaluate five themed lands, four attractions, and four queue environments using a researcher-developed observational instrument. The results of this study determined that Epic Universe effectively sustains immersion through architectural enclosure, intellectual property-based world-building, sensory layering, and interactive technologies that increase guest agency. The park demonstrates a cohesive “self-contained land” model that minimizes negative cues and extends …

Reimagining The Laguna Lake Driving Range, Audrey Bonifacio, Jessica Rice

City and Regional Planning

The Laguna Lake Municipal Golf Course is located in San Luis Obispo, California, and is operated by the city. Recently, the community, city staff, and the City Council have begun a conversation regarding the use of the golf course. To explore the different uses, this senior project presents four alternative developments for a selected area of the golf course. These four uses include enhancing the existing driving range, a sports facility, a children’s center, and a senior living community. To assess these alternatives, the project explores current urban planning theories, development trends, and case studies for each use. Through this …

Leappt: Leveraging Generative Artificial Intelligence-Pediatric Pulmonology Training. Curriculum And Content Development., Alvin Singh, Erin Khan, Mary Moffatt

Manuscripts, Articles, Book Chapters and Other Papers

After redesigning the curriculum of the pediatric pulmonology fellowship program at Children's Mercy-Kansas City, leadership continued to make changes based on feedback from a faculty survey concerned about the quality and structure of didactics. These changes included leveraging generative artificial intelligence to create a detailed course content outline containing specific objectives and study points for each subject related to pediatric pulmonology. Using the content outline as a foundational reference for learners, fellowship leadership continues to enhance the curriculum by creating testing questions, flipped classroom sessions and evaluations, and hope that these specific changes will help address decreased passing rates on …

Improving Public Transport Through Machine Learning Influence Flow Analysis (Mifa): Southern England Bus Case Study, Benjamin Lee, Wolfgang Garn, Masoud Fakhimi, Nick F. Ryman-Tubb

Research Collection School Of Accountancy

Public transport (PT) is crucial for enhancing the quality of life and enabling sustainable urban development. As part of the UK Transport Investment Strategy, increasing PT usage is critical to achieving efficient and sustainable mobility. This paper introduces Machine Learning Influence Flow Analysis (MIFA), a novel framework for identifying the key influencers of PT usage. Using survey data from bus passengers in Southern England, we evaluate machine learning models. Subsequently, MIFA uncovers that easy payments, e-ticketing, and mobile applications can substantially improve the PT service. MIFA’s implementation demonstrates that strength and importance lead to specific insights into how service characteristics …

Systemic Functioning Of Puerto Rican Families With A Cancer Patient: A Qualitative-Oriented Mixed-Methods Study, Nicole M. Velez-Agosto

Psychological Science Faculty Publications

Systemic family interventions of Latino families with a cancer patient have been suggested as effective and necessary, but few studies have focused on evaluating systemic functioning to design culturally relevant interventions. The purpose of study was to assess systemic functioning in Puerto Rican families with a cancer patient using the Spanish translated version of the Family Genogram Interview (FGI) that measures Bowen’s four emotional processes in nuclear family and family of origin. Fifty-one Puerto Rican participants related to a cancer patient were interviewed. Results suggested an acceptable reliability for the FGI-Spanish and higher presence of symptoms in a spouse or …

Disarming Data: An Empirical Take On The Loaded Debate About Felon-In-Possession Of A Firearm, Jonathan Abel

Faculty Scholarship

This Article answers a crucial empirical question at the heart of the scholarly and judicial debates about the laws governing felon-in-possession of a firearm: How often do defendants charged with this offense have violent felony convictions? Using a comprehensive dataset of over 27,000 defendants charged in California from 2021 through 2024, the study provides a novel, large-scale analysis of how prosecutors deploy this most-common gun charge. The findings substantiate longstanding concerns that felon-in-possession is overbroad in its application to nonviolent felons—only 8.5% of defendants had a “violent felony” conviction as defined by California law, rising to just 28.8% under a …

Simulation-Free Spine Palliative Radiotherapy Enabled By Ai-Adapted Diagnostic Ct, Yiding Han, Alexander Nicola Hanania, Zaid Ali Siddiqui, Vincent Ugarte, Boran Zhou, Abdallah S R Mohamed, Piyush Pathak, Daniel Allen Hamstra, Baozhou Sun

Faculty, Staff and Students Publications

Background: Radiotherapy planning traditionally requires a dedicated simulation CT (sCT), which can introduce delays in initiating treatment. This is particularly impactful in spinal palliative care, where timely treatment is often important for symptom control and prevention of neurological deterioration. Although diagnostic CT (dCT) is frequently available earlier in the workflow, it can lead to geometric and dosimetric inaccuracies when used directly for treatment planning due to discrepancies in patient positioning, vertebral alignment, and table curvature.

Purpose: To develop and evaluate an AI-based method that transforms dCT into a simulation-equivalent planning CT (AI-pCT), enabling a clinically feasible simulation-free workflow for spinal …

Disciplining Mechanisms: Governing Data Markets With Competition And Regulation, Peter Ormerod

Faculty Publications

The past decade has witnessed conceptual renewals in both competition law and information privacy law. These regulatory movements—Neo-Brandeis antitrust and structural data governance—share the objective of recalibrating the balance of power between individuals and the massive data-processing firms that now dominate modern life.

Despite their common ends, policy interventions drawn from these schools of thought can work at cross purposes: competitive pressure can induce data exploitation, and privacy rules tend to benefit the largest firms.

This Essay exposes the friction in their relationship and offers guidance on how to mediate their tension. Competition policy alone will prove ineffective at indirectly …

Online Age Gating: An Interdisciplinary Evaluation, Noah Apthorpe, Brett Frischmann, Yan Shvartzshnaider

Faculty Publications

The recent surge in regulation seeking to establish age-based governance online is part of a decades-long attempt to establish online zoning. It is driven by active development of technologies to estimate or verify user age based on various characteristics of users, their credentials, or their activities. However, these developments have heightened prevailing concerns that online age gating technology will inevitably be abused and misused to cause a variety of privacy harms and rights infringements. This paper examines this ongoing debate by bridging technical and legal scholarship to explore the current state of online age-based governance. We discuss the current legal …

Association Of Human Papillomavirus On Risk Of Hiv Acquisition In African Women: Analyses From Mtn-020/Aspire, Christine L. Hathaway, Elizabeth R. Brown, Stephen Cherne, Alyssa L. Sepulveda, Zvavahera M. Chirenje, Nitesha Jeenarain, Logashvari Naidoo, Samantha Siva, Nishanta Singh, Kubashni Woeber

School of Medicine Publications

Background: Observational data on the synergy between human papillomavirus (HPV) infection and risk for HIV acquisition are needed. HPV clearance, associated with an influx of cells targeted by HIV, may increase HIV risk. This study examined the association between HPV and HIV acquisition using endocervical swabs collected in MTN-020/ASPIRE.

Methods: Healthy, sexually active women without HIV participating in the ASPIRE dapivirine ring study in Malawi, South Africa, Uganda, and Zimbabwe provided endocervical swabs monthly, which were tested for HPV-DNA. HPV status was classified into prevalent, persistent (HPV+ for at least 4 months), HPV clearance (HPV+ followed by HPV-), HPV acquisition …

Trust Transference And Cognitive Affective Trust Dichotomy In Tiktok Short-Form Videos: The Moderating Role Of Source Homophily, Rajat Subhra Chatterjee, Mosharrof Hosen, Irfan Hameed, Hafiz Mudassir Rehman

Plymouth Business School

This study explores the under-researched area of cognitive-affective trust transference within the context of short-form videos (SFV) on the TikTok platform. It also provides new insights into the impact of source homophily that arises from viewing SFV. The study incorporates trust transfer theory into the Stimulus-Organism-Response (SOR) model perspective to examine trust transference. Data were gathered from 411 online users in Malaysia using a purposive sampling technique. Partial least squares structural equation modeling has been used to analyze the data via SmartPLS. The findings suggest that video characteristics, platform trust, and source credibility of SFVs on TikTok affect affective trust …

Applying Two-Stage Risk-Based Market Structures For Energy Hub-Based Plug-In Electric Vehicles Using Information Decision Gap Theory And A Hybrid Recurrent Convolutional Network, A. Heidari, R. C. Bansal, R. Bo

Electrical and Computer Engineering Faculty Research & Creative Works

This paper investigates the optimal operation of an energy hub engaged in both day-ahead and real-time trading. A two-stage optimization framework Information Gap Decision Theory (IGDT) for day-ahead bidding and stochastic programming with Monte Carlo scenarios for real-time recourse is applied. Risk-neutral, risk-averse, and risk-taking strategies are considered to capture different risk preferences. The hub integrates combined heat and power, renewable energy, plug-in electric vehicles, and vehicle-to-grid and grid-to-vehicle technologies. Price and load forecasts are generated using a hybrid recurrent convolutional network (HRCN). Results highlight the trade-off between risk management and economic performance: costs are 16.5 % higher in the …

Microwave Dielectric Properties Of Geopolymer Precursor Powders, Linh T. Duong, Abu Naser Rashid Reza, Kristen M. Donnell, Christopher R. Shearer

Electrical and Computer Engineering Faculty Research & Creative Works

Geopolymers are sustainable structural materials with properties similar to ordinary Portland cement concrete. To better understand the fundamental reaction mechanisms of geopolymers, a microwave materials characterization approach is used. In this research work, the dielectric properties (permittivity and loss factor) of common precursor powders used to make geopolymers (GPPs)—fly ash, lime, metakaolin, silica fume, slag, and zeolite—are measured over the S- and X-band frequency ranges (i.e., 2.0–4.0 GHz and 8.2–12.4 GHz, respectively). The physical characteristics, elemental composition, mineralogical properties, and phase characterization of the GPPs are then correlated to dielectric properties. Permittivity of GPP, classified as pozzolanic or latent hydraulic, …

Anaemic Streams: Iron And Essential Trace Metals Frequently Limit Primary Producer Biomass, David M. Costello, Olufemi J. Akinnifesi, Renn C. Schipper, Paisley Kostick, Jordyn T. Stoll, Scott D. Tiegs, Amy Marcarelli, Sally A. Entrekin, Raven L. Bier, Krista A. Capps, Dean E. Fletcher

Michigan Tech Publications

Metals are essential for microbial metabolism, yet their role as limiting nutrients in freshwater streams remains poorly understood. We quantified the prevalence of metal and nutrient (co-)limitation of primary producers in 41 streams. Metal limitation was widespread with Fe limitation eliciting the strongest and most consistent biomass responses (50% of streams). Zn limitation was also common (33% of streams), marking the first evidence of Zn-limited stream biofilms at this spatial scale. Metals were often co-limiting with N and P, highlighting interactions between macro- and micronutrients. Diatoms were more responsive to Zn and cyanobacteria reached higher biomass with N and P …

The Effect Of Si And Zr On The Formation Of Al3x And V-Phase In A 6005a Alloy With Sc—Part 1: Alloy Design And Heat Treatment Selection, Eli A. Harma, Timothy Langan, Paul Sanders

Michigan Tech Publications

Adding Sc to 6xxx series alloys has led to inconsistent results due to the formation of the high-temperature, thermodynamically stable V-phase (AlSc2Si2). Thermo-Calc single-axis equilibrium and phase diagram calculations were employed to identify V-phase formation with varying Si and Zr concentrations, indicating that increasing Zr and decreasing Si lowered the V-phase equilibrium volume fraction. Increasing Zr also shifted the V-phase equilibrium to higher Si concentrations. To access real-world influences of Zr and Si, four compositions were cast with different Si and Zr concentrations: a high-Si, low-Zr alloy; a medium-Si, medium-Zr alloy; a low-Si, high-Zr alloy; and a baseline alloy without …

Calibration Of Time-Domain Impedance Probe (Tdip) To Investigate Space Plasma Dynamics During Periods Of Ionospheric Instability, Piyas Chowdhury, Soumyajit Dey, Edmund A. Spencer

Shelby Hall Graduate Research Forum Posters

The traditional Plasma Impedance Probe (PIP) is popular for diagnosing parameters of the ionospheric plasma to study the space environment. However, the resolution of data measurements of existing PIP instruments, operating at higher frequencies, limits the analysis to studying the plasma features at electron scales. Studying plasma ion parameters is essential to understanding the ionospheric instability growth rates. This can only be accomplished by operating a diagnosing instrument at lower frequencies corresponding to ion scales. A recently developed Time Domain Impedance Probe (TDIP) is implementable for fast moving spacecraft using a time domain approach. The instrument has higher measurement resolution …

Detecting Sensor Data Manipulation, Ricky Green, Michael Black

Shelby Hall Graduate Research Forum Posters

The integration of Information Technology (IT) and Operational Technology (OT) have made OT devices vulnerable to threats that have been successfully exploited with devastating results. Many modern techniques for hardening and securing enterprise IT systems are either incompatible with OT components in an Industrial Control System (ICS), reduce the efficiency of processes, or are prohibitively expensive to implement. Research in the area of ICS security focuses on a top-down approach, such as intrusion prevention by securing the perimeter of the network at layers 3 – 5 of the Purdue model by hardening IT systems. This approach is useful in Enterprise …

Segmental Tracheal Resection For Thyroid Cancer: Perioperative Morbidity, Locoregional Control, And Survival, Anastasios Maniakas, David C Wilde, Isabelle Fournier, Emily K Hyde, Li Xu, Jennifer R Wang, Neil D Gross, Erich M Sturgis, Victoria Banuchi, Naifa L Busaidy, Maria E Cabanillas, Priyanka Iyer, Ramona Dadu, Steven G Waguespack, Mimi I Hu, G Brandon Gunn, Michael Kwon, Salmaan Ahmed, Michelle D Williams, Mark E Zafereo

Faculty, Staff and Student Publications

Background: Segmental tracheal resection is rarely needed for advanced thyroid cancer but is among the most complex, high-risk thyroid surgeries.

Methods: Retrospective study of patients undergoing segmental tracheal resection for thyroid cancer at MD Anderson Cancer Center (2005-2024).

Results: We identified 120 patients with a median follow-up of 4.6 years (range 0.02-16.38). Papillary thyroid cancer was most common (68%). The median number of tracheal rings resected was 4 (range 1-9). Seventeen (14%) patients had a new tracheostomy placed at the time of surgery, with 11 (9%) remaining trach-dependent at last follow-up. Twenty-six (22%) patients had a return to the operating …

Postcolonial Ecocriticism And The Recovery Of Hope: Okri, Dangarembga, And The Spiritual, John C. Hawley

English

This essay stages a comparative ecocritical reading of African and transnational texts—Cajetan Iheka’s Naturalizing Africa, Ben Okri’s Every Leaf a Hallelujah, Tsitsi Dangarembga’s This Mournable Body, Greg Sarris’s Becoming Story, and Karen Armstrong’s Sacred Nature—to examine how narrative re-situates the human within more-than-human worlds. Drawing on Iheka’s “aesthetics of proximity,” postcolonial theory, and critical posthumanism, it contrasts Okri’s hopeful, child-centered fable of multispecies reciprocity with Dangarembga’s portrayal of “slow violence,” psychic dispossession, and eco-touristic commodification in neoliberal Zimbabwe. Indigenous and spiritual frameworks in Sarris and Armstrong further disclose ancient precedents for posthuman ethics, foregrounding humility, …

The Impact Of Genetic Testing On Physician Practice In Specialized Cardiovascular Clinics, Arsalan Hamid, Tyler Sewell, Sucheta Bhatt, Scott Spencer, Damon Hostin, Ginger A Metcalf, Richard A Gibbs, Vijay Nambi, Layla A Abushamat, Christie M Ballantyne

Faculty, Staff and Students Publications

Background: Although familial hypercholesterolemia (FH) is a US Centers for Disease Control and Prevention tier 1 condition for genetic testing, the impact of testing on clinical outcomes is unclear.

Objective: We aimed to assess whether genetic testing alters lipid management in HeartCare participants.

Methods: For participants with pathogenic/likely pathogenic variants for FH observed at Baylor College of Medicine cardiology clinics, data on laboratory values, medication prescriptions, and diagnoses were collected and compared before and after genetic testing.

Results: In the 20 participants with APOB/LDLR variants and complete data, low-density lipoprotein cholesterol (LDL-C) was numerically lower but not significantly different before …

Toward Scientific Rigor: Setting Standards For Indirect Calorimetry Analysis And Reporting, Elizabeth L Lieu, Mark A Herman, Sean M Hartig

Faculty, Staff and Students Publications

Indirect calorimetry determines energy expenditure by measuring respiratory gas exchange. The approach is based on the principle that nutrient metabolism consumes O2 and produces CO2 and water in predictable ratios that can be compared with heat production. Due to the impracticality and high cost of direct calorimetry, indirect calorimetry is the major approach for modern metabolic studies in preclinical models. Despite the broad adoption of this method in rodent phenotyping, the field has lacked standardized methods for analyzing, representing, and sharing these data, limiting scientific progress. The recent review in Nature Metabolism by the International Indirect Calorimetry Consensus Committee (IICCC) …

Predicting Mortality And Costs After Emergency Department Visits By People With Dementia: Timing And Location Matter, Jason K Bowman, Christine S Ritchie, Kei Ouchi, Kyler M Godwin, James A Tulsky, Joan M Teno

Faculty, Staff and Students Publications

Background: People with dementia have high rates of emergency department (ED) and hospital utilization, high mortality and costs, and other poor outcomes. To successfully impact the care trajectories of these patients, health care systems must pragmatically identify the correct target population. This study described patterns of ED utilization by people with dementia and explored the accuracy of administrative data models to predict mortality and costs.

Methods: Retrospective cohort study of a 20% random sample of Traditional Medicare (TM) beneficiaries with dementia, age ≥ 66 years, and an index ED visit in 2018. One-year mortality and high costs were described, and …

Rab4 Spatially And Functionally Converges With Rab7 In The Degradative Endolysosomal Network, Stephen M Farmer, Shiyu Xu, Yue Yu, Xin Ye, Haoyi Yang, Jing Cai, Beatriz Rios, Wen-Wen Lin, Daniela Covarrubias, Vicky Chuong, Lili Ye, German Zylberberg, Charissa Wang, Erin Furr-Stimming, Qingchun Tong, Oguz Kanca, Hugo J Bellen, Travis I Moore, Sheng Zhang

Faculty, Staff and Students Publications

Rab GTPases are key regulators of endosomal trafficking in eukaryotes. In mammalian cells, Rab4 and Rab7 were shown to localize to distinct compartments, with Rab4 on early endosomes for fast recycling and Rab7 on late endosomes for degradation. Here, we show that in Drosophila, endogenous Rab4 and Rab7 extensively colocalize across tissues and developmental stages. Recruited to the same compartments through mechanisms that do not require the activity of the other, they have opposing effects on endolysosomal size: Rab4 overexpression or Rab7 impairment leads to enlarged endolysosomes, whereas Rab4 loss or constitutively active Rab7 reduces their sizes. Rab4 deficiency suppresses …

Lonp1 Variants Are Associated With Clinically Diverse Phenotypes, Randee E Young, Lu Qiao, Rebecca Hernan, David A Sweetser, Jessica L Waxler, Daryl A Scott, Tiana M Scott, Seema R Lalani, Mahshid S Azamian, Jill A Rosenfeld, Bret Bostwick, Lindsay C Burrage, Lance H Rodan, Bianca E Russell, Marina Dutra-Clarke, Michael Kruer, Somayeh Bakhtiarim, Hossein Darvish, David J Amor, Shamima Rahman, Karen Stals, Lisa Bradley, Susan Byrne, Leandra K Tolusso, Beatrix Wong, Laura Benedict, Kimberly Wallis, Kestutis Micke, Cindy Colson, Thomas Smol, Sabrina V Southwick, Kristen A Miller, Michelle L Kush, Odelia Chorin, Annick Rothschild, Wei Wang, Yufeng Shen, Wendy K Chung

Faculty, Staff and Students Publications

LONP1 encodes a mitochondrial protease essential for protein quality control and metabolism. Variants in LONP1 are associated with a diverse and expanding spectrum of disorders, including Cerebral, Ocular, Dental, Auricular, and Skeletal anomalies syndrome (CODAS), congenital diaphragmatic hernia (CDH), and neurodevelopmental disorders (NDD), with some individuals exhibiting features of mitochondrial encephalopathy. We report 16 novel LONP1 variants identified in 16 individuals (11 with NDD, 5 with CDH), further expanding the clinical spectrum. Structural mapping of disease-associated missense variants revealed phenotype-specific clustering, with CODAS variants enriched in the proteolytic chamber and NDD variants more broadly distributed. CODAS is caused by biallelic …

Risk Factors For Acute Rejection In Pediatric Lung Transplantation And Its Impact On Graft Failure, Sophie Li, Spoorthi Kamepalli, David Moreno Mcneill, Selena Li, Abbas Rana

Faculty, Staff and Students Publications

Background: Although acute rejection is a common complication of lung transplantation, few studies have analyzed risk factors for acute rejection in pediatric lung transplant patients. The purpose of this study was to examine risk and protective factors for acute rejection in pediatric lung transplantation and its impact on graft failure.

Methods: A retrospective analysis was performed on lung transplant data for a cohort of 906 pediatric patients from the Organ Procurement and Transplantation Network (OPTN) Database between October 1, 1987, and June 30, 2023. Multivariable logistic regression was conducted to identify risk and protective factors for acute rejection, adjusting for …

The Diagnostic Performance Of The Basic Versus The Detailed Telomere Flow Fish Test In Young Patients With Aplastic Anaemia, Nicholas F Decleene, Duc T Nguyen, Susan E Kirk, Hannah L Helber, Ghadir S Sasa, Alison A Bertuch

Faculty, Staff and Students Publications

Identifying telomere biology disorders (TBDs) in patients with aplastic anaemia (AA) is essential for guiding appropriate care. Telomere length (TL) measurement by flow cytometry with fluorescence in situ hybridization supports diagnosis, but the real-world performance of the basic test (lymphocytes and granulocytes) versus the detailed test (which includes four lymphocyte subsets) remains unclear. We retrospectively reviewed 439 patients who underwent detailed TL testing at our institution from 2008 to 2022. Haematological disease was present in 87%, with AA comprising 56%. We classified 23 subjects with TBD independently of TL, only one of whom had severe AA (SAA) at initial presentation. …

Bortezomib And Vorinostat In Combination With Mitoxantrone, Dexamethasone, And Pegasparaginase During Induction And Reinduction For Infants With Acute Lymphoblastic Leukaemia: A Multicentre Single-Arm Phase 1/2 Study, Tanja A Gruber, Sima Jeha, Rebecca J Deyell, Victor Lewis, Bill H Chang, Eric J Lowe, Jamie Frediani, Catherine Vezina, Bruno Michon, Michael Richards, Erin H Breese, Thai-Hoa Tran, Norman Lacayo, Christine Bolen, Sunil Desai, Jennifer L Pauley, Minxuan Huang, Emily Ashcraft, Cheng Cheng, Kirk R Schultz, Linda Stork, Krysta Schlis, Van T Huynh, Nathan Gossai, Yoav H Messinger, Henrique Bittencourt, Terzah M Horton, Uma Athale, Duncan Stearns, Deborah Schiff, Paul S Gaynon

Faculty, Staff and Students Publications

Background: Acute lymphoblastic leukaemia in infants remains a therapeutic challenge. In preclinical studies we previously identified bortezomib and vorinostat as active agents against KMT2A rearranged (KMT2Ar) leukaemia. The aim of this study was to determine the tolerability of incorporating bortezomib and vorinostat into an acute lymphoblastic leukaemia-chemotherapy backbone for newly diagnosed infants with acute lymphoblastic leukaemia both with and without KMT2Ar.

Methods: In this single-arm phase 1/2 study conducted at 18 hospitals in the USA and Canada, we enrolled patients aged 1 year or younger at the time of diagnosis with newly diagnosed acute lymphoblastic leukaemia or undifferentiated leukaemia (with …

Cardiac Catheterization In American Indian/Alaska Native Populations: Empowering Communities, Providers, And Systems Toward Equity, Joseph Burns, Daniel J Penny, Keila N Lopez, Lindsay F Eilers, Athar M Qureshi, Christine J Chung, Jason F Deen

Faculty, Staff and Students Publications

American Indian/Alaska Native (AI/AN) people face numerous health disparities, including alarming rates of cardiovascular morbidity and mortality. These inequities are closely tied to unique social, political, and economic circumstances due to the ongoing consequences of systemic racism. Although poorly described, these cardiovascular inequities extend to adult and pediatric interventional cardiology. AI/AN adults are less likely to undergo cardiac catheterization and are more likely to experience complications. There are no published studies on pediatric interventional cardiology outcomes in AI/AN children. The scarcity of available data underscores the need for novel studies to investigate the epidemiology, sociodemographic associations, and outcomes of AI/AN …