Digital Commons Network^™

Identification Of Effective Diagnostic Genes And Immune Cell Infiltration Characteristics In Small Cell Lung Cancer By Integrating Bioinformatics Analysis And Machine Learning Algorithms, Yinyi Chen, Kexin Han, Yanzhao Liu, Qunxia Wang, Yang Wu, Simei Chen, Jianlin Yu, Yi Luo, Liming Tan

Saudi Medical Journal

Objectives: To identify potential diagnostic markers for small cell lung cancer (SCLC) and investigate the correlation with immune cell infiltration. Methods: GSE149507 and GSE6044 were used as the training group, while GSE108055 served as validation group A and GSE73160 served as validation group B. Differentially expressed genes (DEGs) were identified and analyzed for functional enrichment. Machine learning (ML) was used to identify candidate diagnostic genes for SCLC. The area under the receiver operating characteristic curves was applied to assess diagnostic efficacy. Immune cell infiltration analyses were carried out. Results: There were 181 DEGs identified. The gene ontology analysis showed that …

Effect Of The Prone Position On Mechanical Power In Elective Surgical Patients Under General Anesthesia: A Prospective Observational Study, Berrak S. Aydın, Eren Açıkgöz

Saudi Medical Journal

Objectives: To evaluate how the prone position influences mechanical power (MP) during elective surgical procedures. Methods: In this prospective study carried out at Karadeniz Ereğli Government Hospital, Zonguldak, Turkey, from January 2024 to February 2024, 76 patients under general anesthesia were evaluated at different time points during the surgical procedure. Hemodynamic, laboratory, and mechanical ventilation data were also recorded. Results: The MP increased in the prone position at the beginning of surgery. Transitioning to the supine position at the end of surgery led to a decrease in MP. At the end of surgery, the mean MP in supine and prone …

Client’S Satisfaction With Healthcare Services Received At The Hospital Outpatients Department And The Primary Healthcare Facilities In Al-Qassim, Saudi Arabia: A Review Of Service Users’ Satisfaction, Ahmad S. Almutairi, Emmanuel F. Osagiede, Sultan K. Alenazi, Abdulaziz A. Almutairi, Yasir S. Alnawmasi, Ahmed A. Aljunaydili, Majed S. Alharbi, Abdulaziz S. Alshahrani

Saudi Medical Journal

Objectives: To assess the level of satisfaction expressed for services rendered in the public health sector to clients who were seen at outpatient departments (OPDs) and primary healthcare (PHC) facilities in Al-Qassim Health Cluster in Saudi Arabia. Methods: This study used a comparative cross-sectional study design, and data were obtained as secondary data from The Patient’s Experience Platform. Data analysis was carried out using Stata (version 16), and the significance level was 5%. Results: In comparing the mean satisfaction in 9 domains, statistically significantly higher means for the PHC facilities than the OPDs were seen across 7 domains: patients navigating …

Epidemiology, Clinical Profiles, And Antimicrobial Susceptibility Of Elizabethkingia Meningoseptica Infections: Insights From A Tertiary Care Hospital In Saudi Arabia, Raghad T. Alhuthil, Raghad M. Hijazi, Ohoud A. Alyabes, Mohammed A. Alsuhaibani, Deema A. Gashgarey, Ibrahim M. Binsalamah, Mohammed A. Aldahmash, Salem M. Alghamdi, Esam A. Albanyan, Suliman A. Aljumaah, Sami H. Al-Hajjar

Saudi Medical Journal

Objectives: To investigate the incidence rate, clinical characteristics across different age groups, antimicrobial susceptibility, and outcomes of Elizabethkingia meningoseptica ( E. meningoseptica ) infections. Methods: A retrospective analysis was carried out to include 66 cases with confirmed E. meningoseptica cultures from sterile samples between January 2014 and June 2022 at King Faisal Specialist Hospital and Research Centre in Riyadh, Saudi Arabia. Results: A total of 66 cases were identified, with an incidence rate of 0.3 per 1000 admissions. Most cases were hospital-acquired (80.3%), primarily in critical care areas. All patients had underlying diseases, with respiratory (40.9%) and cardiovascular (39.4%) diseases …

Obstructive Uropathy In Stat 3 Hyper Immunoglobulin E Syndrome: A 5 Year Old Middle Eastern Boy, Esraa M. Bukhari, Ashwag A. Alsaidalani

Saudi Medical Journal

Autosomal dominant hyper immunoglobulin E (IgE) syndrome is a rare inborn error of immunity that affects approximately one in a million individuals worldwide. It presents with various symptoms owing to multisystem involvement (immunological and non-immunological). Recurrent infections (mainly in the skin and lungs) are common presentations. A 5-year-old Middle Eastern boy presented with symptoms suggestive of obstructive uropathy secondary to multiple large pelviabdominal abscesses and acute kidney injury with hyperkalemia that necessitated admission to the intensive care unit. Upon further investigation, the patient’s genetic test (whole exome sequencing) demonstrated a heterozygous missense variant in the STAT3 gene. The patient completely …

Can Omega-3 Fatty Acid Intake Affect Acne Severity?

Saudi Medical Journal

No abstract provided.

Who Releases First-Ever Clinical Treatment Guideline For Tobacco Cessation In Adults

Saudi Medical Journal

No abstract provided.

Prevalence, Perception, And Attitude Regarding Electronic Cigarettes Usage Among Young Adults In Riyadh, Saudi Arabia. A Cross-Sectional Study, Norah I. Alhumaidan, Lama A. Alzelfawi, Zeena A. Alhindawi, Lena M. Aldosari, Aljoharah M. Altowaijri, Njoud F. Alfaisal

Saudi Medical Journal

Objectives: To determine the prevalence of electronic cigarette (e-cigarette) usage among young adults in Riyadh, Saudi Arabia; their perceptions of its harm and legal age, and the reasons and factors influencing their use. Methods: This cross-sectional study was carried out within the general community of Riyadh, Saudi Arabia, between December 2023 and April 2024. Participants aged 18-25 years were included. A self-administered online questionnaire was used to gather demographic data, perceptions, and attitudes toward e-cigarettes and reasons for their use. Results: The majority of the 476 participants were female (n=378, 79.4%) and Saudi nationals (n=451, 94.7%). Current e-cigarette usage was …

Does Air Pollution Affect Lupus Risk?

Saudi Medical Journal

No abstract provided.

Mind-Body Bridging (Mbb) Techniques And Emotional Regulation In Political Discourse And Confidence In Political Talk, Joseph Ofori Acheampong

All Graduate Theses and Dissertations, Fall 2023 to Present

In today's politically divided landscape, conversations across political lines can often provoke intense feelings of anger and anxiety, making productive dialogue difficult. This polarization not only dampens the quality of public discourse but also affects individual emotional well-being and the broader societal cohesion. This study explores a novel approach to alleviating the negative emotional effects caused by political polarization, using Mind-Body Bridging (MBB) techniques. It specifically targets emotional regulation- how we control and manage our feelings- during political discussions, without attempting to change participants' political beliefs. The study involved participants from Utah State University setting who engaged in MBB training. …

Understanding The Relationship Between Festival Making Practices And Place : An Investigation Into The Making Of Two Community Arts Festivals In Ireland, Danielle Lynch

Doctoral

Although the importance of arts festivals for places is acknowledged in the literature, there is surprisingly limited understanding of festival making as creative practice, and the manner and extent to which place influences this practice. In recent decades, the global proliferation of art festivals has not been met with a commensurate increase in scholarly or critical examinations regarding their form, function, or content (Merrington, 2016). Indeed, existing studies largely focus on the events themselves and their aftermath rather than the processes underpinning their formation and making (Mair & Smith, 2022). This qualitative study addresses this gap and investigates the dialogical …

Mareva Injunction And Crypto Fraud, Man Yip

Research Collection Yong Pung How School Of Law

Without a Mareva injunction, there is always a risk that any victory on the substantive merits would be rendered hollow in practice by the absence of assets against which the judgment may be enforced. Indeed, it is in cases concerning fraud that the risk of a nugatory judgment is most amplified because the defendant would have the propensity to engage in dishonest practices. Alarmingly, nearly 30 years aft er Mercedez Benz, the ‘black hole’ has enlarged because fraudsters can easily hide behind complex corporate structures and the anonymity of cyberspace. 2 Th is chapter focuses on the use of Mareva …

Podcasting For Public Knowledge: A Multiple Case Study Of Scholarly Podcasts At One University, Lindsay Persohn, Rayna Letourneau, Emma Abell-Selby, Jason Boczar, Allison Symulevich, Jessica Szempruch, Matthew Torrence, Thomas Woolf, Audrey Holtzman

USF Libraries Faculty and Staff Publications

Through a lens for engaged scholarship (Boyer in Journal of Public Service and Outreach, 1(1), 11–20, 1996) this multiple case study (Merriam, 1996) explores the potential of scholarly podcasts for public knowledge dissemination, highlighting the misalignment of university impact metrics with this medium. Our team collected qualitative and numerical data from six podcasters across our university system. We identify metrics for assessing scholarly podcast value, offer recommendations for institutional communication, and share our insights and challenges. Data analysis suggests that a Listen Score (Listen Notes, ND) and an increasing Podcast Success Index (Singh et al. JMIR Medical Education, 2(2), 1–10, …

Falsehoods, Foreign Interference, And Compelled Speech In Singapore, Kenny Chng

Research Collection Yong Pung How School Of Law

Online misinformation endangers the infrastructure of fact essential to public discourse and presents an even greater threat where it is being utilised as a weapon by hostile state actors. In recognition of these dangers, Singapore has implemented legal measures to combat online misinformation, enacting in quick succession the Protection from Online Falsehoods and Manipulation Act (POFMA) and the Foreign Interference (Countermeasures) Act (FICA). These statutes open up novel frontiers of development for Singapore's free speech jurisprudence. Indeed, these statutes confer upon government authorities the power to compel the authors of certain material to display notices stating that the material contains …

Negotiating A Brave New World: Fraud And Risk In Modern Commercial Law, Andrew B.L. Phang

Research Collection Yong Pung How School Of Law

We live in a brave new world. Much of what was once the stuff of fiction has now become reality. In particular, we have witnessed technological advances the like of which we would not even have begun to contemplate even at the turn of the second millennium. No one has been exempt – not even this mid-sexagenarian. Now, almost a quarter of a century on, we have to take stock of the double-edged sword that is technology. Indeed, technology has – unfortunately – facilitated fraud in a manner and on a scale that we have never witnessed before. With technology …

How Can Malaysian Courts Consistently Perform Meaningful Constitutional Rights Review? Lessons From Past Cases And The Way Forward, Benjamin Joshua Ong

Research Collection Yong Pung How School Of Law

In the past, Malaysian courts performing constitutional rights review played a merely clerical role, applying a test that was trivially easy for legislation to pass. Then a more rigorous proportionality test took root. However, the Federal Court in the 2020 case of Letitia Bosman whittled the test down again, and the courts once more played a minimal role in checking state action. The reasons for this cannot be explained merely by diversity in judicial philosophy or political contextual factors. Rather, the near-demise of proportionality (and, with it, robust constitutional review) was made possible by a lack of a clear sense …

Political Constructions Of People Who Use Drugs In The Philippines: A Qualitative Content Analysis, Gideon Lasco

Development Studies Faculty Publications

Background

This paper examines the political constructions of people who use drugs in the Philippines throughout the presidency of Rodrigo Duterte (2016–2022), during which the government engaged in a ‘war on drugs’ and promoted a punitive drug regime.

Methods

Building on and drawing inspiration from the global drug policy scholarship that has looked at the ways in which drugs are framed and problematised in various domains, this study used qualitative content analysis to review 96 documents from national government agencies - including strategic action plans, directives, memorandums, guidelines, annual reports, and legislative measures.

Results

Foremost, the study finds that various …

Effect Of Absorption Kinetics Of Superabsorbent Polymers On Printability And Interlayer Bond Of 3d Printing Concrete, Yu Cun Gu, Shuyi Zheng, Hongyan Ma, Wu Jian Long, Kamal H. Khayat

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

This study examines the effect of the material characteristics of superabsorbent polymers (SAPs) on the printability and interlayer bond strength of 3D printing concrete. Three types of SAP, including two acrylamide-co-acrylic polymers with coarse and fine particle sizes (S1 and S2) and an acrylic copolymer (S3), were employed. The investigated mortar mixtures had a fixed initial mini-slump flow of 195 ± 10 mm and yield stress of 290 ± 25 Pa. The fluidity of SAP-incorporated mortars was maintained by either adjusting the superplasticizer dosage or increasing the water content. Test results indicate that particle flocculation is dependent on SAP absorption …

Ten Years As Boundary Object: The Search For Identity And Belonging As 'Hongkongers', John Lowe, Darlene Machell Espena, George Wong

Research Collection College of Integrative Studies

This article examines the complex process of symbolic boundary-making of ‘Hongkonger’ cultural identities through the lens of the controversial 2015 film Ten Years, which is a celebrated omnibus production comprised of five short segments that picture a dystopic end to Hong Kong’s cherished way of life in the year 2025. The article is premised on an interdisciplinary approach engaging with cultural studies and film studies. On one hand, it explores how Ten Years functioned as a boundary object, a vast terrain within which cultural identities of what it means to be a Hongkonger are constructed, banished, imagined, and performed under …

Integration Of Urban Climate Research Within The Global Climate Change Discourse, Negin Nazarian, Benjamin Bechtel, Gerald Mills, Melissa Anne Hart, Ariane Middel, E. Scott Krayenhoff, Gaby S. Langendijk, Lei Zhao, Andy Pitman, Winston T. L. Chow

Research Collection College of Integrative Studies

Global climate science needs to address a fundamental challenge: the mismatch between the scales of anthropogenic processes driving change and the resulting climate impacts. While projected climate changes and impacts are global in extent, the drivers of this change, and the exposure to its impacts, are concentrated in densely populated urban areas. Despite occupying only 1–3% of the land, urban areas are home to most of the world’s population and responsible for ~70% of current greenhouse gas emissions [1]. By 2050, an additional 2.5 billion people are expected to live in urban areas, with up to 90% of this growth …

The Partnership Question As A Scale Question: Extending The Theorization Of Entrepreneurial Urbanism In China, Yong Zhang

Research Collection College of Integrative Studies

In this article I examine recent theoretical and empirical exchanges around partnership-based urban governance between North Atlantic and Chinese academics and policymakers. I argue that the latest wave of de jure private–public partnerships in urban China reflects an ongoing process of governance rescaling beyond conventional entrepreneurial urbanism theory. I propose an analytical framework that foregrounds successive experimental partnerships as tensions between institutional continuity and change arising from rescaling. In this study I examine variegated actually existing partnerships in Jiyuan, China, to identify generalizable ideal types of partnership-driven governance rescaling. I conclude by suggesting to enhance the theorization of entrepreneurial urbanism …

Vertical Expansion In The Making: Planning Against Deindustrialization By Promoting "Industry's Going Upstairs" In Shenzhen, Qianqian Wei, Yong Zhang

Research Collection College of Integrative Studies

In recent years, industrial metropolises in China have experienced a surge in proactive planning initiatives aimed at developing high-rise industrial structures, commonly known as “Industry’s Going Upstairs (IGU).” This study argues that the IGU represents a distinct form of urban verticality that is neither motivated by capitalist speculation nor sustainability prompts but rather by local states’ intervention to ensure economic resilience and enhance innovation capabilities. This study presents the case of Shenzhen to demonstrate how the adoption of the IGU initiative is catalyzed by concerns over manufacturing sectors’ out-migration and the effects of volatile US-China relations on the city’s competitiveness. …

Carbon Capture And Renewable Energy Policies: Could Policy Harmonization Be A Puzzle Piece To Solve The Electricity Crisis?, Mahelet G. Fikru, Fateh Belaïd, Hongyan Ma

Economics Faculty Research & Creative Works

The electricity market crisis, driven by factors such as increased energy demand, rising fuel prices, aging infrastructure, and greenhouse gas emissions, requires a multifaceted approach including the strategic implementation of Carbon Capture and Storage (CCS) technologies, which despite high costs and potential adverse impact on renewable investments, can allow the use of fossil fuels to maintain grid stability, and simultaneously lower carbon footprint. Across the world, several nations are designing financial incentives and improving regulatory frameworks to reduce barriers to the deployment of CCS. However, it is not clearly understood whether and to what extent such policy support would affect …

Press Benefits And The Public Imagination, Erin C. Carroll

Georgetown Law Faculty Publications and Other Works

In an era when the press faces unprecedented challenges, those who believe in the importance of a free press find themselves playing defense. Press advocates have been forced to articulate, with renewed clarity and urgency, why the press is not merely important but vital to an effective democracy and why it needs to be saved from a “death spiral” and an “extinction-level event.” These arguments often focus on the crucial role the press plays—the “press function,” as lawyers call it—in informing the public, holding power to account, and facilitating democratic discourse.

Scholars and commentators generally discuss the press function through …

Bridging Silos: Environmental And Reproductive Justice In The Climate Crisis, Sara A. Colangelo

Georgetown Law Faculty Publications and Other Works

The climate crisis is a perilous yet underexamined example of the intersection of environmental injustice and reproductive injustice. The physical manifestations of the climate crisis affect key elements of reproductive justice: women’s rights to have children, to not have children, and to parent children in healthy, sustainable communities. Reams of studies document climate disaster-driven gender violence, loss of access to healthcare and reproductive services, as well as direct and deadly health effects of climate change on maternal health, fetal development, infants, and children. Despite these profound impacts, the environmental and reproductive justice movements remain largely siloed, particularly in the legal …

How Is Access To Legal Resources And Advocacy Foundational To Health Justice?, Yael Zakai Cannon

Georgetown Law Faculty Publications and Other Works

Health justice as a movement incorporates research about how to more effectively leverage law, policy, and institutions to dismantle inequitable power distributions and accompanying patterns of marginalization that are root causes of health inequity. Legal advocacy is key to health justice because it addresses patients’ health-harming legal needs in housing, public benefits, employment, education, immigration, domestic violence, and other areas of law. In medical-legal partnerships, lawyers and clinicians are uniquely positioned to jointly identify and remove legal barriers to patients’ health, advocate for structural reform, and build community power.

Loneliness Among Black/African American Adults Living With Hiv: Sociodemographic And Psychosocial Correlates And Implications For Adherence., Nipher Malika, Laura M. Bogart, Matt G. Mutchler, Kathy Goggin, David J. Klein, Sean J. Lawrence, Glenn J. Wagner

Manuscripts, Articles, Book Chapters and Other Papers

Loneliness, an emerging public health problem, is higher among people living with HIV and is associated with negative health outcomes. Black/African Americans have a high burden of HIV, and little is known about the characteristics of loneliness among Black adults living with HIV; therefore, this study sought to understand the sociodemographic and psychosocial correlates of Black adults living with HIV who are lonely and the implications of loneliness for their health outcomes. A sample of 304 Black adults living with HIV (73.8% sexual minority men) in Los Angeles County, CA, USA, completed the survey items assessing sociodemographic and psychosocial characteristics, …

Management Of Diabetic Ketoacidosis In Children: Does Early Insulin Glargine Help Improve Outcomes?, Rebecca Ohman-Hanson, G Todd Alonso, Laura Pyle, Ryan Mcdonough, Mark A. Clements

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Rebound hyperglycemia following the resolution of diabetic ketoacidosis (DKA) is common in pediatric patients with type 1 diabetes, increasing the risk of recurrent DKA and complicating the transition to subcutaneous insulin. Multiple studies suggest that early administration of long-acting insulin analogs during DKA management safely improves this transition.

OBJECTIVE: This study aimed to determine whether early insulin glargine administration in children with DKA prevents rebound hyperglycemia and recurrent ketosis without increasing the rate of hypoglycemia or hypokalemia.

METHODS: Patients agedChildren's Mercy Kansas City between October 2012 and October 2016 were reviewed. They were categorized as Early (>4 h …

Using A Collaborative Learning Health System Approach To Improve Disease Activity Outcomes In Children With Juvenile Idiopathic Arthritis In The Pediatric Rheumatology Care And Outcomes Improvement Network., Julia G. Harris, Catherine A. Bingham, Sheetal S. Vora, Cagri Yildirim-Toruner, Michelle Batthish, Danielle R. Bullock, Jon M. Burnham, Danielle C. Fair, Kerry Ferraro, Suhas Ganguli, Mileka Gilbert, Beth S. Gottlieb, Olha Halyabar, Melissa M. Hazen, Ronald M. Laxer, Tzielan C. Lee, Alice Liu, Daniel J. Lovell, Melissa L. Mannion, Edward J. Oberle, Nancy Pan, Michael Shishov, Jennifer E. Weiss, Esi M. Morgan

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: The Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) is a North American learning health network focused on improving outcomes of children with juvenile idiopathic arthritis (JIA). JIA is a chronic autoimmune disease that can lead to morbidity related to persistent joint and ocular inflammation. PR-COIN has a shared patient registry that tracks twenty quality measures including ten outcome measures of which six are related to disease activity. The network's global aim, set in 2021, was to increase the percent of patients with oligoarticular or polyarticular JIA that had an inactive or low disease activity state from 76% to …

Evaluation Of The Alveolar Crest And Cemento-Enamel Junction In Periodontitis Using Object Detection On Periapical Radiographs, Tai Jung Lin, Yi Cheng Mao, Yuan Jin Lin, Chin Hao Liang, Yi Qing He, Yun Chen Hsu, Shih Lun Chen, Tsung Yi Chen, Chiung An Chen, Kuo Chen Li, Patricia Angela R. Abu

Ateneo Laboratory for Intelligent Visual Environments

The severity of periodontitis can be analyzed by calculating the loss of alveolar crest (ALC) level and the level of bone loss between the tooth’s bone and the cemento-enamel junction (CEJ). However, dentists need to manually mark symptoms on periapical radiographs (PAs) to assess bone loss, a process that is both time-consuming and prone to errors. This study proposes the following new method that contributes to the evaluation of disease and reduces errors. Firstly, innovative periodontitis image enhancement methods are employed to improve PA image quality. Subsequently, single teeth can be accurately extracted from PA images by object detection with …