Digital Commons Network^™

Pbi-05204, A Supercritical Co2 Extract Of Nerium Oleander, Suppresses Glioblastoma Stem Cells By Inhibiting Grp78 And Inducing Programmed Necroptotic Cell, Sharmistha Chakraborty, Daoyan Wei, Megan Tran, Frederick F Lang, Robert A Newman, Peiying Yang

Faculty, Staff and Student Publications

Successful treatment of glioblastoma multiforme (GBM), an aggressive form of primary brain neoplasm, mandates the need to develop new therapeutic strategies. In this study, we investigated the potential of PBI-05204 in targeting GBM stem cells (GSCs) and the underlying mechanisms. Treatment with PBI-05204 significantly reduced both the number and size of tumor spheres derived from patient-derived GSCs (GBM9, GSC28 and TS543), and suppressed the tumorigenesis of GBM9 xenografts. Moreover, PBI-05204 treatment led to a significant decrease in the expression of CD44 and NANOG, crucial markers of progenitor stem cells, in GBM9 and GSC28 GSCs. This treatment also down-regulated GRP78 expression …

A Comparison Of Available Guidelines For The Detection Of Cauda Equina Syndrome And Assessing The Need For Further Clinical Guidance In Ireland, Lorcan Gavin, Michael G Curran, John P Mccabe

Faculty, Staff and Student Publications

The cauda equina syndrome (CES) is a rare but critical disorder, which can result in devastating motor weakness and sensory deficit, alongside often irreversible bladder, bowel and sexual dysfunction. In addition to the clinical burden of disease, this syndrome results in a disproportionately high medicolegal strain due to missed or delayed diagnoses. Despite being an emergency diagnosis, often necessitating urgent surgical decompression to treat, we believe there is a lack of clarity for clinicians in the current literature, with no published Irish guideline concerning screening or detection. The current study aims to identify and analyse appropriate guidelines in relation to …

Social Determinants Of Long-Term Opioid Use Following Total Knee Arthroplasty, Katherine Hadlandsmyth, Brian C Lund, Yubo Gao, Andrea L Strayer, Heather Davila, Leslie R M Hausmann, Susanne Schmidt, Paula K Shireman, Michael A Jacobs, Michael J Mader, Robert A Tessler, Carly A Duncan, Daniel E Hall, Mary Vaughan Sarrazin

Faculty, Staff and Student Publications

Total knee arthroplasty (TKA) risks persistent pain and long-term opioid use (LTO). The role of social determinants of health (SDoH) in LTO is not well established. We hypothesized that SDoH would be associated with postsurgical LTO after controlling for relevant demographic and clinical variables. This study utilized data from the Veterans Affairs Surgical Quality Improvement Program, VA Corporate Data Warehouse, and Centers for Medicare and Medicaid Services, including Veterans aged ≥ 65 who underwent elective TKA between 2013 and 2019 with no postsurgical complications or history of significant opioid use. LTO was defined as > 90 days of opioid use beginning …

Care Fragmentation, Social Determinants Of Health, And Postoperative Mortality In Older Veterans, Carly A Duncan, Michael A Jacobs, Yubo Gao, Michael Mader, Susanne Schmidt, Heather Davila, Katherine Hadlandsmyth, Paula K Shireman, Leslie R M Hausmann, Robert A Tessler, Andrea Strayer, Mary Vaughan Sarrazin, Daniel E Hall

Faculty, Staff and Student Publications

Introduction: Veterans Affairs Surgical Quality Improvement Program (VASQIP) benchmarking algorithms helped the Veterans Health Administration (VHA) reduce postoperative mortality. Despite calls to consider social risk factors, these algorithms do not adjust for social determinants of health (SDoH) or account for services fragmented between the VHA and the private sector. This investigation examines how the addition of SDoH change model performance and quantifies associations between SDoH and 30-d postoperative mortality.

Methods: VASQIP (2013-2019) cohort study in patients ≥65 y old with 2-30-d inpatient stays. VASQIP was linked to other VHA and Medicare/Medicaid data. 30-d postoperative mortality was examined using multivariable logistic …

Differential Behavior Of Conformational Dynamics In Active And Inactive States Of Cannabinoid Receptor 1, Ugochi H. Isu, Adithya Polasa, Mahmoud Moradi

Chemistry & Biochemistry Faculty Publications and Presentations

Cannabinoid receptor 1 (CB1) is a G protein-coupled receptor that regulates critical physiological processes including pain, appetite, and cognition. Understanding the conformational dynamics of CB1 associated with transitions between inactive and active signaling states is imperative for developing targeted modulators. Using microsecond-level all-atom molecular dynamics simulations, we identified marked differences in the conformational ensembles of inactive and active CB1 in apo. The inactive state exhibited substantially increased structural heterogeneity and plasticity compared to the more rigidified active state in the absence of stabilizing ligands. Transmembrane helices TM3 and TM7 were identified as distinguishing factors modulating the state-dependent dynamics. TM7 …

Recent Advances In Magnetic Feˣ⁺/Tio₂ Microfibers For Wastewater Treatment As Climate Change Mitigation, Misriani Misriani, Yang Tian, Z. Ryan Tian

Chemistry & Biochemistry Faculty Publications and Presentations

Chemical dyeing and finishing processes used in the clothing and textile industries are among the main contributors that can increase the impact of climate change. Photocatalysis using nanosized titanium dioxide (TiO₂) has been continuously developed as a promising technology for purifying dye wastewater into simpler and environmentally friendly components. In addition, the decoration of iron cations (Fe²⁺) and (Fe³⁺) increases the reusability of the photocatalyst due to their magnetic properties, which are easy to collect for the recycling process. Magnetic Fe^x+/TiO₂ microfibers have been successfully prepared using a hydrothermal method using …

A Qualitative Exploration To Inform An Oral Health Training For Disability Care Workers In Burkina Faso, Ave Põld, Dan Filwendé Kientega, Jocelyne Valérie Garé, Michael Lorenz

Faculty, Staff and Student Publications

AIM: To explore enablers and barriers to the creation of an oral health training for care workers at specialized centres for children with disabilities in Ouagadougou.

DESIGN: This was a formative study informed by the Theoretical Domains Framework using qualitative methods.

METHODS: Qualitative observations and 14 semi-structured interviews were conducted with care workers from six specialized centres for disability.

RESULTS: Carer workers emphasized that a successful oral health training must account for available resources and competencies in each specific centre. Part of the training must be dedicated to oral hygiene targeted for people with disabilities and provide knowledge about risk …

Racial Discrimination Increases The Risk For Nonremitting Posttraumatic Stress Disorder Symptoms In Traumatically Injured Black Individuals Living In The United States, Lucas Torres, Timothy J. Geier, Carissa W. Tomas, Claire M. Bird, Sydney Clare Timmer-Murillo, Christine L. Larson, Terri A. Deroon-Cassini

Psychology Faculty Research and Publications

Traumatic, life-threatening events are experienced commonly among the general U.S. population, yet Black individuals in the United States (i.e., Black Americans) exhibit higher prevalence rates of posttraumatic stress disorder (PTSD) and more severe symptoms than other populations. Although empirical research has noted a range of symptom patterns that follow traumatic injury, minimal work has examined the role of racial discrimination in relation to PTSD symptom trajectories. The current study assessed racial discrimination and PTSD symptom trajectories at 6 months postinjury across two separate samples of traumatically injured Black Americans (i.e. emergency department (ED)–discharged and hospitalized). Identified PTSD symptom trajectories largely …

Neurocognitive Functioning In Adults With Trichotillomania: Predictors Of Treatment Response And Symptom Severity In A Randomized Control Trial, Kathryn E. Barber, Douglas W. Woods, Thilo Deckersbach, Christopher C. Bauer, Scott N. Compton, Michael P. Twohig, Emily J. Ricketts, Jordan Robinson, Stephen M. Saunders, Martin E. Franklin

Psychology Faculty Research and Publications

Trichotillomania (TTM) is associated with impairments in response inhibition and cognitive flexibility, but it is unclear how such impairments relate to treatment outcome. The present study examined pre-treatment response inhibition and cognitive flexibility as predictors of treatment outcome, change in these domains from pre-to post-treatment, and associations with TTM severity. Participants were drawn from a randomized controlled trial comparing acceptance-enhanced behavior therapy (AEBT) to psychoeducation and supportive therapy (PST) for TTM. Adults completed assessments at pre-treatment (n = 88) and following 12 weeks of treatment (n = 68). Response inhibition and cognitive flexibility were assessed using the Stop …

Service Dog Knowledge And Utilization In Occupational Therapy Practice, Lauren E. Garcia, Sierra P. Mcnicol

Graduate Student Scholarship

The assumed efficacy behind service dog intervention is based on the well-known potential for the development of a strong, emotional bond between humans and dogs. Occupational therapists can use knowledge of their specific scope of practice to aid in the referral process, and the assessment process, and to help assist clients with training and comfortability throughout the service dog placement process. Existing literature on service dog use and implementation within occupational therapy (OT) practice is limited and lacking in rigor, internal and external validity, and reliability. The aims of the current study include evaluating the level of education occupational therapy …

My Manager Endorsed My Coworkers’ Voice: Understanding Observers’ Positive And Negative Reactions To Managerial Endorsement Of Coworker Voice., Emily Poulton, Szu-Han Joanna Lin, Shereen Fatimah, Cony Ho, Lance Ferris, Russell Johnson

Research Collection Lee Kong Chian School Of Business

Research on managerial voice endorsement has primarily focused on the processes and conditions through which voicers receive their managers’ endorsement. We shift this focus away from the voicers, focusing instead on the dual reactions that endorsement generates for observing employees. Drawing from an approach-avoidance framework, we propose that managerial endorsement of coworker voice could be perceived as a positive and negative stimulus for observers, prompting them to approach opportunities and avoid threats, respectively. Results from a pre-registered experiment and a multi-wave, multi-source field study revealed that managerial endorsement of coworker voice was positively related to observers’ voice instrumentality, thus prompting …

The Impact Of Ectopic Expression Of A Plant Elicitor Peptide In Bacillus Subtilis On Nematode Resistance In Soybean Through Seed Treatment, Abeer Alnasrawi

Graduate Theses and Dissertations

Soybean (Glycine max) is the most beneficial legume crop because it is a source of protein as well as oil for humans and livestock. Soybean is the second most planted crop in the United States following corn and it is also the fourth planted crop worldwide. However, the soybean cyst nematode (Heterodera glycines, SCN) is the most damaging pest of soybean in the United States, accounting for more than twice as much yield loss as the following cause of yield loss in soybean. Therefore, there is a pressing need to develop alternative management strategies to control SCN infection in soybeans. …

The Surgical Infection Society Guidelines On The Management Of Intra-Abdominal Infection: 2024 Update, Jared M Huston, Philip S Barie, E Patchen Dellinger, Joseph D Forrester, Therese M Duane, Jeffrey M Tessier, Robert G Sawyer, Miguel A Cainzos, Kemal Rasa, Jeffrey G Chipman, Lillian S Kao, Frederic M Pieracci, Kristin P Colling, Daithi S Heffernan, Janice Lester

Faculty, Staff and Student Publications

Background: The Surgical Infection Society (SIS) published evidence-based guidelines for the management of intra-abdominal infection (IAI) in 1992, 2002, 2010, and 2017. Here, we present the most recent guideline update based on a systematic review of current literature.

Methods: The writing group, including current and former members of the SIS Therapeutics and Guidelines Committee and other individuals with content or guideline expertise within the SIS, working with a professional librarian, performed a systematic review using PubMed/Medline, the Cochrane Library, Embase, and Web of Science from 2016 until February 2024. Keyword descriptors combined "surgical site infections" or "intra-abdominal infections" in adults …

Assessment Of Thrombectomy Versus Combined Thrombolysis And Thrombectomy In Patients With Acute Ischemic Stroke And Medium Vessel Occlusion, Adam A Dmytriw, Sherief Ghozy, Hamza Adel Salim, Basel Musmar, James E Siegler, Hassan Kobeissi, Hamza Shaikh, Jane Khalife, Mohamad Abdalkader, Piers Klein, Thanh N Nguyen, Jeremy J Heit, Robert W Regenhardt, Nicole M Cancelliere, Kareem El Naamani, Abdelaziz Amllay, Lukas Meyer, Anne Dusart, Flavio Bellante, Géraud Forestier, Aymeric Rouchaud, Suzana Saleme, Charbel Mounayer, Jens Fiehler, Anna Luisa Kühn, Ajit S Puri, Christian Dyzmann, Peter T Kan, Marco Colasurdo, Gaultier Marnat, Jérôme Berge, Xavier Barreau, Igor Sibon, Simona Nedelcu, Nils Henninger, Thomas R Marotta, Christopher J Stapleton, James D Rabinov, Takahiro Ota, Shogo Dofuku, Leonard L L Yeo, Benjamin Y Q Tan, Juan Carlos Martinez-Gutierrez, Sergio Salazar-Marioni, Sunil Sheth, Leonardo Renieri, Carolina Capirossi, Ashkan Mowla, Nimer Adeeb, Hugo H Cuellar-Saenz, Stavropoula I Tjoumakaris, Pascal Jabbour, Priyank Khandelwal, Arundhati Biswas, Frédéric Clarençon, Mahmoud Elhorany, Kevin Premat, Iacopo Valente, Alessandro Pedicelli, João Pedro Filipe, Ricardo Varela, Miguel Quintero-Consuegra, Nestor R Gonzalez, Markus A Möhlenbruch, Jessica Jesser, Vincent Costalat, Adrien Ter Schiphorst, Vivek Yedavalli, Pablo Harker, Lina M Chervak, Yasmin Aziz, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Ramanathan Kadirvel, Monika Killer-Oberpfalzer, Christoph J Griessenauer, Ajith J Thomas, Cheng-Yang Hsieh, David S Liebeskind, Răzvan Alexandru Radu, Andrea M Alexandre, Illario Tancredi, Tobias D Faizy, Robert Fahed, Charlotte S Weyland, Boris Lubicz, Aman B Patel, Vitor Mendes Pereira, Adrien Guenego, Mad-Mt Consortium

Faculty, Staff and Student Publications

Background

The combination of intravenous thrombolysis (IVT) with mechanical thrombectomy (MT) may have clinical benefits for patients with medium vessel occlusion.

Purpose

To examine whether MT combined with IVT is associated with different outcomes than MT alone in patients with acute ischemic stroke (AIS) and medium vessel occlusion.

Materials and Methods

This retrospective study included consecutive adult patients with AIS and medium vessel occlusion treated with MT or MT with IVT at 37 academic centers in North America, Asia, and Europe. Data were collected from September 2017 to July 2021. Propensity score matching was performed to reduce confounding. Univariable and …

On Counter-Memes: A Rhetorical Study Of Allyship In Social Media Memetics From 2015-2024, Kaitlyn Samons

All Dissertations

This dissertation examines the importance of Online allyship through a newly coined term in Memetics and Mis- and Disinformation: “Counter-Memeship.” This work combines previous contributing works on “memes,” “counter-memes,” “counter-stories,” and “allyship” through the lens of feminist, white, and communication theories. Internet memes and studies are explored by looking at how Online participants in internet spaces interact with each other in modern-day protests in memetic ways. The researcher utilizes descriptive and exploratory methods to articulate better how internet memes work between 2015 and 2024. The primary purpose of this research is to see whether Online protests can be considered non-performative …

Equilibria And Effective Transition Rates In Linear Networks, Sayani Ghosh

All Dissertations

Investigating equilibration in nucleosynthetic processes is crucial for understanding stellar chemical abundances in nuclear astrophysical scenarios. While current computational models are effective at predicting final species abundances at the end of these stellar processes, they fail to provide insights into the evolution of equilibrium. Without this deeper understanding, it is challenging to determine the impact of individual reaction rates on timescales and the resultant equilibrium.

In this work, we model nucleosynthetic processes as directed graphs. We develop theorems that allow us to express the mass fractions of species as spanning arborescences of these graphs. By obtaining eigenvalues in terms of …

Using Mixed-Reality Simulation To Teach Job Interview Skills To Young Adults With Intellectual Disabilities, Alex Carlson

All Dissertations

Job interviews are a critical step to obtaining employment, however, the social demands of job interviews are often difficult for individuals with intellectual disabilities (ID). Both the use of technology (e.g., mixed-reality simulation, video modeling, virtual reality) and attending inclusive postsecondary education programs that teach independent living skills and employment skills have been effective in improving job interview skills and employment outcomes. Using an underpowered randomized-control trial research design, the researcher examined whether using mixed-reality simulation technology to practice job interview skills improved job interview skill acquisition for young adults with ID compared to face-to-face practice that is typically conducted …

Exploring Equity In Introductory Biology Genetics Education, Sandy G. Phillips-Long

All Dissertations

The dissertation “Exploring Equity in Introductory Biology Genetics Education” delved into the critical examination of equity within undergraduate genetics education. Chapter One outlined the background, significance, research framework, and manuscripts included in this study. Chapter Two was a scoping review that provided an overview of the current pedagogical approaches in undergraduate genetics education. It identified six active learning pedagogies: Course-based Undergraduate Research Experience (CURE); group work; case-based learning; inquiry-based learning; Virtual Reality (VR); and Consider, Read, Elucidate the hypothesis, Analyze and interpret the data, and Think of the next Experiment (CREATE). Chapter Three was a systematic literature review investigating pedagogical …

Value Of Transportation Information Systems: Implications Of Digital Platforms, Third-Party Forecasting, And Advanced Driver-Assistance Systems, Ali Shirzadibabakan

All Dissertations

This three-essay dissertation focuses on understanding the impacts of IT, or IT enabled business models, on transportation and supply chains. Specifically, it empirically examines the market and societal implications of digital freight platforms, third-party forecasting, and cyber-physical systems in the transportation and supply chain sectors. Leveraging the entry of the Amazon Freight platform into the trucking freight industry as an exogenous shock, the first essay finds that adding a digital platform-enabled spot marketplace addresses the prevalent problem of the performance (rejection) of nonbinding contracts in the trucking industry. Specifically, the platform’s effect manifests through two primary mechanisms: increasing suppliers’ transportation …

Capillary Phenomena In Flow Down Fibers: Beads, Bridges, Sheets, And Threads, Chase Tyler Gabbard

All Dissertations

Capillary phenomena are ubiquitous in everyday life with surface tension responsible for shaping liquids and deforming slender structures on length scales smaller than the capillary length, as seen in the formation of drops from a leaky faucet and in the coalescence of wet hair, respectively. Recently, thin film flow down fibers have received significant attention for their ability to produce bead-on-fiber patterns with associated high surface area-to-volume ratios that optimize retention times in heat and mass transfer applications. The presence of a base flow gives rise to complex dynamics including absolute and convective instabilities. The parallelization of these processes through …

Convex Approach To Data-Driven Optimal Control With Safety Constraints Using Linear Transfer Operator, Joseph Raphel Moyalan

All Dissertations

This thesis is concerned with the data-driven solution to the optimal control problem with safety constraints for a class of control-affine nonlinear systems. Designing optimal control satisfying safety constraints is a problem of interest in various applications, including robotics, power systems, transportation networks, and manufacturing. This problem is known to be non-convex. One of this thesis's main contributions is providing a convex formulation to this non-convex problem. The second main contribution is providing a data-driven framework for solving the control problem with safety constraints. The linear operator theoretic framework involving Perron-Frobenius and Koopman operators provides the convex formulation and associated …

Virtually Coached Nature-Based Activities For Perceived Stress In Rural-Dwelling Families With A Teenager With Autism Spectrum Disorder, Deborah R. Logan

All Dissertations

Families with teenagers with autism spectrum disorder (ASD) can experience more stress than families without teenagers with ASD due to individuals with ASD often exhibiting social behaviors that differ from social norms, and parents having to adjust their expectations and future goals for their child with ASD. Rural-dwelling families of teenagers with ASD may experience additional stress due to their having to travel to access therapeutic services. Research focused on family-based services aimed at decreasing stress among rural-dwelling families of teenagers with ASD is lacking. The purpose of this convergent mixed methods study was to explore the feasibility of an …

Building Resilience To Contagious Diseases In High Contact Services: An Investigation Of Customers’ Willingness To Dine-In At Restaurants In The Era Of Covid, Hongli Ye

All Dissertations

High customer contact services play a crucial role in our economy, providing essential interactions and experiences that drive numerous industries. However, the COVID-19 pandemic has posed significant challenges to these sectors due to their inherent characteristics, requiring close and frequent interactions. To rebound from the disruptions caused by such a contagious disease, service providers must adopt innovative strategies. Thus, this dissertation addresses the dynamic nature of building resilience strategies in high-contact services, which are affected by contagious diseases. In doing so, we propose an integrative framework that outlines essential new service resilience components, based on the CDC guidelines, to conventional …

Fantastic Trolls And Where To Find Them: Problem Framing In The Defense Against The Informational Dark Arts, Jayson M. Warren

All Dissertations

In the wake of Russian interference in the 2016 U.S. presidential election, the notion of state-sponsored trolls engaging in information operations on social media has captured the attention of society. Yet eight years after this policymaking focusing event, sustainable solutions prove elusive and there is still much that is not known about the underlying phenomenon. This dissertation is part explanatory and part exploratory in its attempts to answer the overarching research question: What is the Relationship Between How the Problem of State-Sponsored Trolls on Social Media is Framed & the Way U.S. Federal Policy Attempts to Solve It? Using …

Integrating Artificial Intelligence And Augmented Reality For Enhanced Task Performance In The Construction Industry, Aasish Chandrika Bhanu

All Dissertations

The Architecture, Engineering, and Construction (AEC) sector, characterized by its complex tasks, often faces challenges in adopting cutting-edge technologies, a trend that can significantly hinder productivity improvements compared to other industries. This dissertation explores the emerging integration of Artificial Intelligence (AI) and Augmented Reality (AR) within the AEC domain, investigating how effectively this can be implemented to potentially revolutionize industry practices. AI could be used in the AEC domain for advanced analytical and decision-making processes, while AR could be used for training, visualization, and remote collaboration.

In scenarios where construction site workers require expert guidance, these technologies could be helpful. …

Harry Potter And The Immersive Space: A Rhetorical Analysis Of The Wizarding World Of Harry Potter, Kendra Bolin

Electronic Theses and Dissertations

The ability of humans to share stories has changed over time. From myths shared around a campfire to the introduction of cinema, we can now tell massive, immersive stories on an epic scale. One example of this is the storytelling present in theme parks. Present-day theme parks are continuously growing and expanding each year both in size and attendance. The continued success of these theme parks and the rhetorical influences of their audiences is a cultural phenomenon that deserves rhetorical scrutiny. My analysis looks at how one theme park, the Wizarding World of Harry Potter in Orlando, Florida, immerses guests …

Influence Of Stimulation Frequency On Brain-Derived Neurotrophic Factor And Cathepsin-B Production In Healthy Young Adults, Yuichi Nishikawa, Hiroyuki Sakaguchi, Tatsuya Takada, Noriaki Maeda, Allison S. Hyngstrom

Physical Therapy Faculty Research and Publications

Electrical muscle stimulation (EMS) has been shown to stimulate the production of myokines (i.e., brain-derived neurotrophic factor (BDNF)), but the most effective EMS parameters for myokine production have not been fully elucidated. The purpose of this study was to quantify the optimal EMS frequency for stimulating myokine production. This study included sixteen young adults (male, n = 13, age = 27.3 ± 5.5 years). Participants underwent four EMS interventions (20 min each) with the following conditions: (1) 4 Hz, (2) 20 Hz, (3) 80 Hz, and (4) control (no intervention). Blood samples were obtained before and immediately after EMS. For …

Digital Reflection: Harnessing Tanner’S Clinical Judgment Model To Connect With The New Generation Of Nurses, Jayme Weber, Katlyn Messner

Posters and Presentations: College of Nursing

No abstract provided.

Not Ready: The Need For A Training Standard In Healthcare Emergency Preparedness, Patrina White

Dissertations: Doctor of Public Health

Background: Disasters, both natural and human-induced, are increasing. Disasters impact public health and safety in many ways including disruption of healthcare. Emergency preparedness mitigates disaster impacts. Training improves preparedness however no training standard exists. Purpose: This study aimed to explore the current state of U.S. healthcare preparedness and the impact of training on preparedness; determine the best strategies to improve healthcare emergency preparedness training; propose a standard for training in healthcare emergency preparedness; and identify barriers to adopting a standard for training in healthcare emergency preparedness including strategies to overcome identified barriers. Methods: A comprehensive literature review, …

A Two-Part Validation Study Of The Sexual Minority Identity Emotion Scale, Henrietta Kadi Tettey-Tawiah

Graduate Theses and Dissertations

A number of existing studies indicate that there is some correlation between pride and shame and various behavioral health outcomes like anxiety, depression, and self-harm in the general population. Research also confirms that this relationship is true among sexual minorities as well. This study sets itself up to interrogate this assertion vis-à-vis sexual minority adolescents (SMAs). Consequently, confirmatory factor analysis (CFA) and differential item functioning (DIF) detection analysis were performed on the 35-item Sexual Minority Identity Emotion Scale (SMIES) for SMAs. A tree-based modeling technique, specifically conditional inference trees (CIT), was then employed to explore and make predictions about the …