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Articles 151081 - 151110 of 1738257
Full-Text Articles in Entire DC Network
Perturbative Versus Non-Perturbative Renormalization, S. Hariharakrishnan, Ulrich D. Jentschura, I. G. Marian, K. Szabo, I. Nandori
Perturbative Versus Non-Perturbative Renormalization, S. Hariharakrishnan, Ulrich D. Jentschura, I. G. Marian, K. Szabo, I. Nandori
Physics Faculty Research & Creative Works
Approximated functional renormalization group (FRG) equations lead to regulator-dependent β-functions, in analogy to the scheme-dependence of the perturbative renormalization group (pRG) approach. A scheme transformation redefines the couplings to relate the β-functions of the FRG method with an arbitrary regulator function to the pRG ones obtained in a given scheme. Here, we consider a periodic sine-Gordon scalar field theory in d = 2 dimensions and show that the relation of the FRG and pRG approaches is intricate. Although both the FRG and the pRG methods are known to be sufficient to obtain the critical frequency β c 2 = 8 …
Doubly Differential Cross Sections For Ionization In Proton Collisions With Atomic Hydrogen: Energy And Angular Distribution Of Emitted Electrons, C. T. Plowman, K. H. Spicer, N. W. Antonio, M. S. Schöffler, Michael Schulz, I. Bray, A. S. Kadyrov
Doubly Differential Cross Sections For Ionization In Proton Collisions With Atomic Hydrogen: Energy And Angular Distribution Of Emitted Electrons, C. T. Plowman, K. H. Spicer, N. W. Antonio, M. S. Schöffler, Michael Schulz, I. Bray, A. S. Kadyrov
Physics Faculty Research & Creative Works
We use the two-center wave-packet convergent close-coupling approach to ion-atom collisions to calculate the energy and angular distribution of electrons emitted in proton collisions with atomic hydrogen. Results are provided across a wide range of intermediate energies where many competing reaction channels make calculations challenging. The present data consistently agree with the available experimental measurements and improve upon previously available results based on perturbative and classical methods. Furthermore, we extend the range of electron angles and energies over which theoretical data are available for the doubly differential cross section for ionization. This provides strong evidence that at the level of …
Exploring New Frontiers In Hospitality And Tourism, Faizan Ali
Exploring New Frontiers In Hospitality And Tourism, Faizan Ali
Journal of Global Hospitality and Tourism
As we embark on the second issue of Volume 3 of the Journal of Global Hospitality and Tourism, we are presented with a rich and diverse collection of research that investigates contemporary challenges and innovations within our dynamic field. This issue features a diverse range of studies that illuminate emerging trends, address critical issues, and offer practical insights for both industry practitioners and academics.
Do Social Support, Supervisory Feedback, And Job Stress Matter To An Employee’S Sense Of Ownership? Context In The Lodging Sector, Aladin M. Ibrahim, Zyra R. Cabrera, Rodin S. Pescuela
Do Social Support, Supervisory Feedback, And Job Stress Matter To An Employee’S Sense Of Ownership? Context In The Lodging Sector, Aladin M. Ibrahim, Zyra R. Cabrera, Rodin S. Pescuela
Journal of Global Hospitality and Tourism
In the face of intensified competition within the hospitality sector, exacerbated by the challenges of post-pandemic recovery, organizations are increasingly focused on re-engaging employees impacted by workforce reductions and retaining those who demonstrate a strong sense of attachment, care, and commitment to their workplace. These ownership behaviors are pivotal in fostering organizational stewardship and driving performance. However, the question arises: how can organizations cultivate and enhance these positive employee behaviors? This study investigates the influence of leader- and work-related factors, including social support, supervisory feedback, and job stress, on employees’ sense of ownership towards their organization. Employing a survey methodology, …
Championing Retention In The Hospitality Industry – Leveraging The Strengths Of A Multigenerational Workforce, Laur-Ann Daley
Championing Retention In The Hospitality Industry – Leveraging The Strengths Of A Multigenerational Workforce, Laur-Ann Daley
Journal of Global Hospitality and Tourism
The hospitality and tourism industry has a long history of high turnover rates and businesses are constantly scrambling to fill vacancies. With four generations occupying the industry’s workforce, leaders are further challenged with fostering harmony in an attempt to increase their retention rates. Despite the challenges in leading a generationally diverse team, given their unique values, businesses can realize strategic advantages. This opinion paper highlights the strengths of multigenerational teams and how they can be leveraged for competitive benefits.
Bridging The Digital Divide In Hospitality And Tourism: Digital Inclusion For Disadvantaged, Xi Y. Leung
Bridging The Digital Divide In Hospitality And Tourism: Digital Inclusion For Disadvantaged, Xi Y. Leung
Journal of Global Hospitality and Tourism
As technology continues to revolutionize the hospitality and tourism industry, the issues of digital equity and digital divide have gained increasing prominence (Minghetti & Buhalis, 2010; Reverte & Luque, 2021). While digital advancements offer unprecedented opportunities for businesses and consumers, they also risk exacerbating existing inequalities (Wu & Yang, 2023). This is particularly evident in the growing digital divide, referring to the capabilities gap of individuals, groups and regions to access and process digital information technology (OECD, 2001). The rapid pace of technological advancement has left certain groups struggling to keep up. These digital disadvantaged groups—comprising individuals with limited access …
Stem Students’ International Mobility In Kazakhstan In The Context Of The Russia-Ukraine War Conflict
Journal of Comparative & International Higher Education
Special Issue
Digital Payments And Consumption: Evidence From The 2016 Demonetization In India, Sumit Agarwal, Pulak Ghosh, Jing Li, Tianyue Ruan
Digital Payments And Consumption: Evidence From The 2016 Demonetization In India, Sumit Agarwal, Pulak Ghosh, Jing Li, Tianyue Ruan
Research Collection School Of Economics
We study how consumer spending responds to digital payments, using the differential switch to digital payments across consumers induced by the sudden 2016 Indian Demonetization for identification. Usage of digital payments rose by 3.38 percentage points and monthly spending increased by 3% for an additional 10 percentage points in prior cash dependence. Spending remained elevated even when cash availability recovered. Robustness analyses show that the spending response is not driven by income shocks, credit supply, price changes, or consumers' moving to the formal market. We provide evidence that digital payments increase consumer spending due to subdued salience.
Value Capture And Affordable Housing: Insights From Singapore, Sock Yong Phang
Value Capture And Affordable Housing: Insights From Singapore, Sock Yong Phang
Research Collection School Of Economics
To explain the role of value capture in Singapore’s progress, I will first provide some background information on Singapore and its housing sector. I will then take you on a journey back to the 1960s to show how we established our present institutional arrangements for land and housing. I will next describe how housing policies have evolved over the past six decades in response to changing contexts. Finally, I will conclude with the fiscal implications of successful value capture. Where relevant, I will indicate how Singapore’s policies align with George’s views.
Projection-Domain Low-Count Quantitative Spect (Lc-Qspect) Methods For Radiopharmaceutical Therapies (Rpts), Zekun Li
McKelvey School of Engineering Graduate Student Theses & Dissertations
Radiopharmaceutical therapies (RPTs) using α- or β-particle-emitting isotopes are becoming increasingly important in cancer treatment. Reliable (accurate and precise) quantification of absorbed doses in lesions and vital organs is important for the safety and effectiveness of these therapies. Quantitative single-photon emission computed tomography (SPECT) provides a mechanism for such dose quantifications by quantifying the regional activity uptake. This dissertation aims to develop methodologies for reliable SPECT-based regional uptake quantification for patients treated with α-particle-emitting RPTs (α-RPTs). A significant challenge with conventional reconstruction-based quantitative (RBQ) SPECT methods is the ill-posed nature of image reconstruction, which is further complicated by the limited …
Topic Modeling On Document Networks With Dirichlet Optimal Transport Barycenter, Ce Zhang, Hady Wirawan Lauw
Topic Modeling On Document Networks With Dirichlet Optimal Transport Barycenter, Ce Zhang, Hady Wirawan Lauw
Research Collection School Of Computing and Information Systems
Text documents are often interconnected in a network structure, e.g., academic papers via citations, Web pages via hyperlinks. On the one hand, though Graph Neural Networks (GNNs) have shown promising ability to derive effective embeddings for such networked documents, they do not assume a latent topic structure and result in uninterpretable embeddings. On the other hand, topic models can infer semantically interpretable topic distributions for documents by associating each topic with a group of understandable key words. However, most topic models mainly focus on plain text within documents and fail to leverage network structure across documents. Network connectivity reveals topic …
On The Effect Of Driving Turbulent-Like Fluctuations On A Harris Current Sheet Configuration And The Formation Of Plasmoids, Jeffersson A. Agudelo Rueda, Yi-Hsin Liu, Kai Germaschewski, Michael Hesse, Naoki Bessho
On The Effect Of Driving Turbulent-Like Fluctuations On A Harris Current Sheet Configuration And The Formation Of Plasmoids, Jeffersson A. Agudelo Rueda, Yi-Hsin Liu, Kai Germaschewski, Michael Hesse, Naoki Bessho
Faculty Publications
Energy dissipation in collisionless plasmas is one of the most outstanding open questions in plasma physics. Magnetic reconnection and turbulence are two phenomena that can produce the conditions for energy dissipation. These two phenomena are closely related to each other in a wide range of plasmas. Turbulent fluctuations can emerge in critical regions of reconnection events, and magnetic reconnection can occur as a product of the turbulent cascade. In this study, we perform 2D particle-in-cell simulations of a reconnecting Harris current sheet in the presence of turbulent fluctuations to explore the effect of turbulence on the reconnection process in collisionless …
The Effect Of Trauma On Student Academic Achievement, Wendi N. Petersen
The Effect Of Trauma On Student Academic Achievement, Wendi N. Petersen
Masters Projects
This paper explores what current research says about the significant effect that childhood trauma has on student academic achievement. It looks at the ways in which students are impacted by trauma, how this affects them in the classroom and finally recommends a solution to help support educators and school staff in providing a safe, compassionate and encouraging classroom environment for students to learn and thrive in. Educators encounter numerous challenges in today's classrooms. The diverse needs of students today create a unique set of obstacles that teachers must navigate and address in their teaching. Students affected by childhood trauma present …
A Retrospective Comparison Between Analytical Anisotropic Algorithm (Aaa) And Acuros Xb (Axb) Calculation Algorithms Concerning The Left Anterior Descending Coronary Artery Radiation Dose In Left Breast Cancer Patients Utilizing Deep Inspiration Breath Hold, Melissa Wilkinson
Masters Projects
Abstract
Background: Minimizing radiation exposure to the left anterior descending coronary artery (LAD) is crucial during left-sided breast cancer radiation therapy to prevent cardiac complications. Dose calculation algorithms can significantly impact the estimated LAD dose. This study investigates the differences between the Anisotropic Analytical Algorithm (AAA) and Acuros XB (AXB) algorithms in LAD dose calculations.
Methods: Thirty patients treated with radiation therapy after breast-conserving surgery were included. Dosimetric data for LAD, including mean and maximum dose, was calculated using AAA and AXB algorithms. The results were compared using statistical analysis.
Results: Statistically significant reductions in mean LAD dose were observed …
Increasing Secondary Students’ Spanish Oral Language Proficiency, Courtney Kozak
Increasing Secondary Students’ Spanish Oral Language Proficiency, Courtney Kozak
Masters Projects
Research has demonstrated the importance of students becoming orally proficient after taking foreign language classes. This project explores what can be done to combat the issue of students failing to gain an oral proficiency. It addresses instructional design and teacher impact, as well as student contribution to the issue. Multiple studies were reviewed on the best research backed practices for proficiency growth. After reading through all the research, it was determined that a proficiency-based instructional style that followed ACTFL World Readiness standards is the ideal approach. Going hand in hand with a proficiency-based instructional style is a classroom design of …
Announcing The 2024 Induction Of Members Into The Accounting Hall Of Fame, American Accounting Association
Announcing The 2024 Induction Of Members Into The Accounting Hall Of Fame, American Accounting Association
Accounting Hall of Fame Brochures
No abstract provided.
Mapping The Single-Cell Differentiation Landscape Of Osteosarcoma, Danh D Truong, Corey Weistuch, Kevin A Murgas, Prasad Admane, Bridgette L King, Jes Chauviere Lee, Salah-E Lamhamedi-Cherradi, Jyothishmathi Swaminathan, Najat C Daw, Nancy Gordon, Vidya Gopalakrishnan, Richard G Gorlick, Neeta Somaiah, Joseph O Deasy, Antonios G Mikos, Allen Tannenbaum, Joseph Ludwig
Mapping The Single-Cell Differentiation Landscape Of Osteosarcoma, Danh D Truong, Corey Weistuch, Kevin A Murgas, Prasad Admane, Bridgette L King, Jes Chauviere Lee, Salah-E Lamhamedi-Cherradi, Jyothishmathi Swaminathan, Najat C Daw, Nancy Gordon, Vidya Gopalakrishnan, Richard G Gorlick, Neeta Somaiah, Joseph O Deasy, Antonios G Mikos, Allen Tannenbaum, Joseph Ludwig
Faculty, Staff and Student Publications
Purpose: The genetic intratumoral heterogeneity observed in human osteosarcomas poses challenges for drug development and the study of cell fate, plasticity, and differentiation, which are processes linked to tumor grade, cell metastasis, and survival.
Experimental design: To pinpoint errors in osteosarcoma differentiation, we transcriptionally profiled 31,527 cells from a tissue-engineered model that directs mesenchymal stem cells toward adipogenic and osteoblastic fates. Incorporating preexisting chondrocyte data, we applied trajectory analysis and non-negative matrix factorization to generate the first human mesenchymal differentiation atlas.
Results: This "roadmap" served as a reference to delineate the cellular composition of morphologically complex osteosarcoma tumors and quantify …
Why Do Patients With Cancer Die?, Adrienne Boire, Katy Burke, Thomas R Cox, Theresa Guise, Mariam Jamal-Hanjani, Tobias Janowitz, Rosandra Kaplan, Rebecca Lee, Charles Swanton, Matthew G Vander Heiden, Erik Sahai
Why Do Patients With Cancer Die?, Adrienne Boire, Katy Burke, Thomas R Cox, Theresa Guise, Mariam Jamal-Hanjani, Tobias Janowitz, Rosandra Kaplan, Rebecca Lee, Charles Swanton, Matthew G Vander Heiden, Erik Sahai
Faculty, Staff and Student Publications
Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. Many patients with cancer experience reduced life expectancy and have metastatic disease at the time of death. However, the more precise causes of mortality and patient deterioration before death remain poorly understood. This scarcity of information, particularly the lack of mechanistic insights, presents a challenge for the development of novel treatment strategies to improve the quality of, and potentially extend, life for patients with late-stage cancer. In addition, earlier deployment of existing strategies to prolong quality of life is highly desirable. In this …
Of Masks And Men: A Look At Ensor's Christ's Entry Into Brussels And The Art Historical Canon, Addison Speier
Of Masks And Men: A Look At Ensor's Christ's Entry Into Brussels And The Art Historical Canon, Addison Speier
Epochs Art History Journal
It is easy to miss what the title of James Ensor’s 1888 painting Christ’s Entry into Brussels 1889 (fig. 1) dictates as the subject. The sheer amount of visual information needed to be taken in proving almost too much for a viewer to handle, one’s eyes getting lost in the sea of masked figures and bright colors. However, in the center of the piece, distinguishable only by his golden halo, Jesus stands in the midst of the eager crowd. Above the crowd, a banner proclaims “Vive la Sociale” (Long live the Social) a phrase mirrored by “Vive Jesus, Roi de, …
Can Anorectal Stenosis Be Managed With Dilations Alone? A Pcplc Review., Zoe M. Saenz, Kelly Austin, Jeffrey R. Avansino, Andrea Badillo, Casey M. Calkins, Megan M. Durham, Megan K. Fuller, Ankur Rana, Ron W. Reeder, Rebecca M. Rentea, Michael D. Rollins, K Elizabeth Speck, Richard J. Wood, Jamie C. Harris, Jamie Anderson, Maheen Hassan, Payam Saadai, Pediatric Colorectal And Pelvic Learning Consortium (Pcplc)
Can Anorectal Stenosis Be Managed With Dilations Alone? A Pcplc Review., Zoe M. Saenz, Kelly Austin, Jeffrey R. Avansino, Andrea Badillo, Casey M. Calkins, Megan M. Durham, Megan K. Fuller, Ankur Rana, Ron W. Reeder, Rebecca M. Rentea, Michael D. Rollins, K Elizabeth Speck, Richard J. Wood, Jamie C. Harris, Jamie Anderson, Maheen Hassan, Payam Saadai, Pediatric Colorectal And Pelvic Learning Consortium (Pcplc)
Manuscripts, Articles, Book Chapters and Other Papers
PURPOSE: Congenital anorectal stenosis is managed by dilations or operative repair. Recent studies now propose use of dilations as the primary treatment modality to potentially defer or eliminate the need for surgical repair. We aim to characterize the management and outcomes of these patients via a multi-institutional review using the Pediatric Colorectal and Pelvic Learning Consortium (PCPLC) registry.
METHODS: A retrospective database review was performed using the PCPLC registry. The patients were evaluated for demographics, co-morbidities, diagnostic work-up, surgical intervention, current bowel management, and complications.
RESULTS: 64 patients with anal or rectal stenosis were identified (57 anal, 7 rectal) from …
Genomic Insights Into Pediatric Intestinal Inflammatory And Eosinophilic Disorders Using Single-Cell Rna-Sequencing., Marissa R. Keever-Keigher, Lisa Harvey, Veronica Williams, Carrie A Vyhlidal, Atif A Ahmed, Jeffrey J. Johnston, Daniel A. Louiselle, Elin Grundberg, Tomi Pastinen, Craig A. Friesen, Rachel Chevalier, Craig Smail, Valentina Shakhnovich
Genomic Insights Into Pediatric Intestinal Inflammatory And Eosinophilic Disorders Using Single-Cell Rna-Sequencing., Marissa R. Keever-Keigher, Lisa Harvey, Veronica Williams, Carrie A Vyhlidal, Atif A Ahmed, Jeffrey J. Johnston, Daniel A. Louiselle, Elin Grundberg, Tomi Pastinen, Craig A. Friesen, Rachel Chevalier, Craig Smail, Valentina Shakhnovich
Manuscripts, Articles, Book Chapters and Other Papers
INTRODUCTION: Chronic inflammation of the gastrointestinal tissues underlies gastrointestinal inflammatory disorders, leading to tissue damage and a constellation of painful and debilitating symptoms. These disorders include inflammatory bowel diseases (Crohn's disease and ulcerative colitis), and eosinophilic disorders (eosinophilic esophagitis and eosinophilic duodenitis). Gastrointestinal inflammatory disorders can often present with overlapping symptoms necessitating the use of invasive procedures to give an accurate diagnosis.
METHODS: This study used peripheral blood mononuclear cells from individuals with Crohn's disease, ulcerative colitis, eosinophilic esophagitis, and eosinophilic duodenitis to better understand the alterations to the transcriptome of individuals with these diseases and identify potential markers of …
A Qualitative Narrative Study Of Rescue And Recovery Workers Responding To The Terrorist Bombing Of Oklahoma City's Murrah Building, E Whitney Pollio, Jennifer Wang, Edward Randle, David E Pollio, Carol S North
A Qualitative Narrative Study Of Rescue And Recovery Workers Responding To The Terrorist Bombing Of Oklahoma City's Murrah Building, E Whitney Pollio, Jennifer Wang, Edward Randle, David E Pollio, Carol S North
Faculty, Staff and Student Publications
OBJECTIVE: Much of disaster mental health research uses quantitative methods, focusing on numerical prevalence, services, and outcomes.
METHODS: Qualitative methods can provide more detailed, rich, and spontaneous insights into personal disaster experiences, yielding important insights beyond deductive methods. This large-scale qualitative narrative study examined experiences of 181 Oklahoma City bombing rescue/recovery workers.
RESULTS: Thematic narrative content of the bombing experience arose from personal accounts of the bomb blast by rescue/recovery workers proceeding chronologically from initial awareness and deployment to harrowing onsite search and rescue/recovery missions to the aftermath with reflections on the bombing.
CONCLUSIONS: Beyond disaster recovery/rescue worker stories published …
Markov Models For Clinical Decision-Making In Radiation Oncology: A Systematic Review, Lucas B Mccullum, Aysenur Karagoz, Cem Dede, Raul Garcia, Fatemeh Nosrat, Mehdi Hemmati, Seyedmohammadhossein Hosseinian, Andrew J Schaefer, Clifton D Fuller
Markov Models For Clinical Decision-Making In Radiation Oncology: A Systematic Review, Lucas B Mccullum, Aysenur Karagoz, Cem Dede, Raul Garcia, Fatemeh Nosrat, Mehdi Hemmati, Seyedmohammadhossein Hosseinian, Andrew J Schaefer, Clifton D Fuller
Faculty, Staff and Student Publications
The intrinsic stochasticity of patients' response to treatment is a major consideration for clinical decision-making in radiation therapy. Markov models are powerful tools to capture this stochasticity and render effective treatment decisions. This paper provides an overview of the Markov models for clinical decision analysis in radiation oncology. A comprehensive literature search was conducted within MEDLINE using PubMed, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Only studies published from 2000 to 2023 were considered. Selected publications were summarized in two categories: (i) studies that compare two (or more) fixed treatment policies using Monte Carlo simulation …
Why Do Patients With Cancer Die?, Adrienne Boire, Katy Burke, Thomas R Cox, Theresa Guise, Mariam Jamal-Hanjani, Tobias Janowitz, Rosandra Kaplan, Rebecca Lee, Charles Swanton, Matthew G Vander Heiden, Erik Sahai
Why Do Patients With Cancer Die?, Adrienne Boire, Katy Burke, Thomas R Cox, Theresa Guise, Mariam Jamal-Hanjani, Tobias Janowitz, Rosandra Kaplan, Rebecca Lee, Charles Swanton, Matthew G Vander Heiden, Erik Sahai
Faculty, Staff and Student Publications
Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. Many patients with cancer experience reduced life expectancy and have metastatic disease at the time of death. However, the more precise causes of mortality and patient deterioration before death remain poorly understood. This scarcity of information, particularly the lack of mechanistic insights, presents a challenge for the development of novel treatment strategies to improve the quality of, and potentially extend, life for patients with late-stage cancer. In addition, earlier deployment of existing strategies to prolong quality of life is highly desirable. In this …
Outcome Of 3q262/Mecom Rearrangements In Chronic Myeloid Leukemia, Hiroki Akiyama, Hagop Kantarjian, Elias Jabbour, Ghayas Issa, Fadi G Haddad, Nicholas J Short, Shimin Hu, Jo Ishizawa, Michael Andreeff, Koji Sasaki
Outcome Of 3q262/Mecom Rearrangements In Chronic Myeloid Leukemia, Hiroki Akiyama, Hagop Kantarjian, Elias Jabbour, Ghayas Issa, Fadi G Haddad, Nicholas J Short, Shimin Hu, Jo Ishizawa, Michael Andreeff, Koji Sasaki
Faculty, Staff and Student Publications
Study aims: To evaluate the outcomes of patients with 3q26.2/MECOM-rearranged chronic myeloid leukemia (CML).
Methods: We reviewed consecutive adult patients with 3q26.2/MECOM-rearranged CML between January 1, 1998 and February 16, 2023. Rearrangements of 3q26.2/MECOM were confirmed by conventional cytogenetics, and fluorescence in situ hybridization starting in 2015.
Results: We identified 55 patients with MECOM-rearranged CML, including 23 in chronic phase (CP) or accelerated phase (AP) and 32 in blast phase (BP). Nine patients (16%) achieved a major cytogenetic response (MCyR) or deeper. At a median follow-up of 89 months, median survival was 14 months. The 5-year survival rate was 19% …
Combination Of Dasatinib And Venetoclax In Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia, Elias Jabbour, Fadi G Haddad, Koji Sasaki, Bing Z Carter, Yesid Alvarado, Cedric Nasnas, Lewis Nasr, Lucia Masarova, Naval Daver, Naveen Pemmaraju, Nicholas J Short, Jeffrey Skinner, Tapan Kadia, Gautam Borthakur, Guillermo Garcia-Manero, Farhad Ravandi, Ghayas C Issa, Michael Andreeff, Hagop Kantarjian
Combination Of Dasatinib And Venetoclax In Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia, Elias Jabbour, Fadi G Haddad, Koji Sasaki, Bing Z Carter, Yesid Alvarado, Cedric Nasnas, Lewis Nasr, Lucia Masarova, Naval Daver, Naveen Pemmaraju, Nicholas J Short, Jeffrey Skinner, Tapan Kadia, Gautam Borthakur, Guillermo Garcia-Manero, Farhad Ravandi, Ghayas C Issa, Michael Andreeff, Hagop Kantarjian
Faculty, Staff and Student Publications
Background: The dual inhibition of the BCR::ABL1 tyrosine kinase and BCL-2 could potentially deepen the response rates of chronic myeloid leukemia in chronic phase (CML-CP). This study evaluated the safety and efficacy of the combination of dasatinib and venetoclax.
Methods: In this phase 2 trial, patients with CML-CP or accelerated phase (clonal evolution) received dasatinib 50 mg/day for three courses; venetoclax was added in course 4 for 3 years. The initial venetoclax dose was 200 mg/day continuously but reduced later to 200 mg/day for 14 days, and to 100 mg/day for 7 days per course once a molecular response (MR)4.5 …
Ephb2 Receptor Promotes Dermal Fibrosis In Systemic Sclerosis, Erika S A Egal, Severin Donald Kamdem, Masaaki Yoshigi, Ching-Chu Yang, Sarah Pellizzari, Ernest M Kameni, My N Helms, Shervin Assassi, Mark Henkemeyer, Tracy M Frech, Patrice N Mimche
Ephb2 Receptor Promotes Dermal Fibrosis In Systemic Sclerosis, Erika S A Egal, Severin Donald Kamdem, Masaaki Yoshigi, Ching-Chu Yang, Sarah Pellizzari, Ernest M Kameni, My N Helms, Shervin Assassi, Mark Henkemeyer, Tracy M Frech, Patrice N Mimche
Faculty, Staff and Student Publications
Objective: Erythropoietin-producing hepatocellular (Eph)/Ephrin cell-cell signaling is emerging as a key player in tissue fibrogenesis. The aim of this study was to test the hypothesis that the receptor tyrosine kinase EphB2 mediates dermal fibrosis in systemic sclerosis (SSc).
Methods: We assessed normal and SSc human skin biopsies for EphB2 expression. The in vivo role of EphB2 in skin fibrosis was investigated by subjecting EphB2-knockout mice to both bleomycin-induced and tight skin (Tsk1/+) genetic mouse models of skin fibrosis. EphB2 kinase-dead and overactive point mutant mice were used to evaluate the role of EphB2 forward signaling in bleomycin-induced dermal fibrosis. In …
Community Reintegration After A Psychiatric Hospitalization: Perceptions Of Psychiatric Facility Providers, Paige Radtke
Community Reintegration After A Psychiatric Hospitalization: Perceptions Of Psychiatric Facility Providers, Paige Radtke
Walden Dissertations and Doctoral Studies
Reintegrating into the community after a psychiatric hospitalization can be a daunting task, and one that patients with serious and persistent mental illness (SPMI) may experience multiple times throughout their lifetime. While research has been conducted demonstrating the barriers to successful community reintegration after a psychiatric hospitalization, a better understanding of the lived experiences of inpatient social workers regarding the discharge process is necessary to continue to decrease the risk of re-hospitalization. The purpose of the study was to identify the perceived elements necessary to establish successful discharge plans such that patients with SPMI are less likely to experience subsequent …
Spirituality And Self-Management Of Diabetes Among African American Women, Tiaa Reshawn Padgette
Spirituality And Self-Management Of Diabetes Among African American Women, Tiaa Reshawn Padgette
Walden Dissertations and Doctoral Studies
Spirituality plays an important role of support for many people; however, little is known about the role spirituality plays in helping manage chronic conditions such as type 2 diabetes (T2D). African American women (AAW) have the highest incidence of T2D compared to other racial and ethnic groups, which demonstrates the need to learn more about improving health and reducing diabetes in AAW. The purpose of this qualitative narrative inquiry, using Roy’s adaptation model as the theoretical framework, was to assess the role of spirituality in how AAW with T2D manage their illness and whether that role changes according to disease …
Cluster-Based Toxicity Estimation Of Osteoradionecrosis Via Unsupervised Machine Learning: Moving Beyond Single Dose-Parameter Normal Tissue Complication Probability By Using Whole Dose-Volume Histograms For Cohort Risk Stratification, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Cem Dede, Travis C Salzillo, Lisanne V Van Dijk, Abdallah S R Mohamed, Stephen Y Lai, Andrew J Schaefer, Clifton D Fuller
Cluster-Based Toxicity Estimation Of Osteoradionecrosis Via Unsupervised Machine Learning: Moving Beyond Single Dose-Parameter Normal Tissue Complication Probability By Using Whole Dose-Volume Histograms For Cohort Risk Stratification, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Cem Dede, Travis C Salzillo, Lisanne V Van Dijk, Abdallah S R Mohamed, Stephen Y Lai, Andrew J Schaefer, Clifton D Fuller
Faculty, Staff and Student Publications
PURPOSE: Given the limitations of extant models for normal tissue complication probability estimation for osteoradionecrosis (ORN) of the mandible, the purpose of this study was to enrich statistical inference by exploiting structural properties of data and provide a clinically reliable model for ORN risk evaluation through an unsupervised-learning analysis that incorporates the whole radiation dose distribution on the mandible.
METHODS AND MATERIALS: The analysis was conducted on retrospective data of 1259 patients with head and neck cancer treated at The University of Texas MD Anderson Cancer Center between 2005 and 2015. During a minimum 12-month posttherapy follow-up period, 173 patients …