Digital Commons Network^™

The Development And Content Validity Of An Assessment Instrument In Simulation For Advanced Practice Provider Fellowship Programs: An Exploratory Study, Olivia Nicastro

Dissertations

Advanced practice provider (APP) fellowship programs are comprehensive programs designed for physician assistants (PAs) and nurse practitioners (NPs) to acquire the necessary knowledge and skills to deliver safe, high-quality care in their specialized areas of practice (Advanced Practice Provider Fellowship Accreditation TM, 2023). An APP fellowship program’s mission is to guide the APP fellow to an expected level of confidence in meeting core competencies within a specific specialty (Klimpl et al., 2019; Reville & Foxwell, 2021). The assessment of competence is often a complex process. Simulation has become a learning modality across the globe in medical, nursing, and pharmacy in …

Nursing Faculty As Self-Care Influencers: Current Nursing Students’ Perspectives, Shane Yardley

Dissertations

The future of health care depends on nurses who can provide expert patient care and are equally prepared to care for themselves. This balance allows nurses to effectively model caring for themselves to their patients while also enabling them to withstand the inevitable rigors of the profession. As role models, nursing faculty exhibit behaviors that influence students or role aspirants' ability and motivation to successfully perform self-care. For nursing faculty to be intentional in their influence in this area, they must understand what students interpret as helpful and detrimental in facilitating their self-care. The purpose of this study was to …

Rethinking Jazz Education In The Digital Age, Matthew Ryan York

Dissertations

Many resources for jazz educators and students are readily available online for free. With consistent video content and online platform growth across the globe, jazz educators are called upon to engage within this digital discourse. Additionally, they must find new ways of adopting these resources and administer them within their curriculum. How can educators effectively utilize online video resources within their curriculum without altering the existing course offerings to match those of their music education degree counterparts? Almost ten years ago research showed that “streaming from Netflix and YouTube accounted for 50 percent of all North America fixed network data” …

Transcriptomics Analysis Reveals Potential Regulatory Role Of Nsmase2 (Smpd3) In Nervous System Development And Function Of Middle-Aged Mouse Brains, Zhihui Zhu, Timothy S. Mcclintock, Erhard Bieberich

Markey Cancer Center Faculty Publications

Neutral sphingomyelinase-2 (nSMase2), gene name sphingomyelin phosphodiesterase-3 (Smpd3), is a key regulatory enzyme responsible for generating the sphingolipid cer- amide. The function of nSMase2 in the brain is still controversial. To better under- stand the functional roles of nSMase2 in the aging mouse brain, we applied RNA-seq analysis, which identified a total of 1462 differentially abundant mRNAs between +/fro and fro/fro, of which 891 were increased and 571 were decreased in nSMase2-deficient mouse brains. The most strongly enriched GO and KEGG annota- tion terms among transcripts increased in fro/fro mice included synaptogenesis, syn- apse development, synaptic signaling, axon development, and …

Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition: Insights Into Cellular Mechanisms And Signaling Pathways, Sarah Mohammed Alqithami, Amrita Machwe, David K. Orren

Markey Cancer Center Faculty Publications

This review delves into the molecular complexities underpinning the epithelial-to-mesenchymal transition (EMT) induced by cigarette smoke (CS) in human bronchial epithelial cells (HBECs). The complex interplay of pathways, including those related to WNT//β-catenin, TGF-β/SMAD, hypoxia, oxidative stress, PI3K/Akt, and NF-κB, plays a central role in mediating this transition. While these findings significantly broaden our understanding of CS-induced EMT, the research reviewed herein leans heavily on 2D cell cultures, highlighting a research gap. Furthermore, the review identifies a stark omission of genetic and epigenetic factors in recent studies. Despite these shortcomings, the findings furnish a consolidated foundation not only for the …

Cryo-Em Reconstruction Of Oleate Hydratase Bound To A Phospholipid Membrane Bilayer, Michael L. Oldham, M. Zuhaib Qayyum, Ravi C. Kalathur, Charles O. Rock, Christopher D. Radka

Markey Cancer Center Faculty Publications

Oleate hydratase (OhyA) is a bacterial peripheral membrane protein that catalyzes FAD-dependent water addition to membrane bilayer-embedded unsaturated fatty acids. The opportunistic pathogen Staphylococcus aureus uses OhyA to counteract the innate immune system and support colonization. Many Gram-positive and Gram-negative bacteria in the microbiome also encode OhyA. OhyA is a dimeric flavoenzyme whose carboxy terminus is identified as the membrane binding domain; however, understanding how OhyA binds to cellular membranes is not complete until the membrane-bound structure has been elucidated. All available OhyA structures depict the solution state of the protein outside its functional environment. Here, we employ liposomes to …

Nsd3::Nutm1 Fusion Sarcoma Mimicking Malignant Peripheral Nerve Sheath Tumor With Prolonged Survival, Jing Di, Ali M. Alhaidary, Chi Wang, Jinge Liu, Sainan Wei, Joseph Valentino, Therese J. Bocklage

Markey Cancer Center Faculty Publications

Nuclear Protein in Testis (NUT)-rearranged tumors comprise predominantly NUT car- cinoma but also include certain lymphomas, leukemias, skin appendage tumors, and sarcomas. Although histologically diverse, all are genetically identified by oncogenic rearrangement in the NUTM1 gene. Many fusion partners occur, and NSD3 is NUT carcinoma’s third most common partner. Herein, we present a case of a 26-year-old man with an NSD3::NUTM1 fusion sarcoma. The patient presented at the age of 13 months with a scalp nodule. Over the next 24 years, he experienced five local recurrences and ultimately expired of a rapidly progressive recurrence. His treatment included surgical resections, radiation, …

Inflation Expectations, Price Equations, And Fed Effects, Ray C. Fair

Cowles Foundation Discussion Papers

This paper makes three main contributions. First, inflation expectation equations are estimated using quarterly time series data. Second, a price equation in level form is estimated that is consistent with the data, unlike Phillips-curve equations. Third, the case is considered in which an expectation variable in an inflation or price equation is not causal.

The results suggest that household inflation expectations are mostly affected by current and past inflation. The Fed through interest rates has a modest effect. In the estimated price equation a measure of the expected future price level is significant, although it may not be causal. Whether …

Future-Ready Digitalized Education: Unraveling The Dynamics Of Sustainable And Ethical Digital Transformation, Vaishnavi Rode

Electronic Theses, Projects, and Dissertations

Amid the brisk advancement of digital technologies, higher educational institutions and universities are finding themselves at a crucial turning point, with significant obstacles and new prospects in the realm of digital transformation. This culminating experience project delves deeply into the compounded terrain of digital transformation in higher education, emphasizing the need for sustainable practices in the face of rapidly evolving technical advancements. The research questions are: (Q1) What strategies can universities adopt to foster digital literacy among students and faculty while promoting sustainability values within their digital education programs and Why? (Q2) What ethical considerations, concerning data privacy and digital …

Classification Model For Discovering The Type Of Crop To Plant Using Ensemble Techniques, Uma Mahesh Addanki

Electronic Theses, Projects, and Dissertations

Farming plays a role in ensuring survival, especially with the growing need for increased agricultural output. It is vital for farmers to efficiently choose the crops to cultivate. By using crop recommendation systems farmers can make decisions on what crops to plant leading to yields and improved resource management. The success of crop production depends on maintaining the balance of soil nutrients and favorable weather conditions. In this research project, we created a crop recommendation system utilizing learning methods to predict the appropriate crops based on essential soil nutrients and weather patterns. We worked with a dataset sourced from Kaggle, …

Development Of A Cookbook To Increase Calcium Intake In Black Women, Janai Yvonne-Aubrey Johnson

Electronic Theses, Projects, and Dissertations

Background:

Black women face considerable challenges in maintaining adequate calcium intake due to limited access to nutrition education and calcium-rich foods. This issue is compounded by the global prevalence of lactose intolerance, affecting 75% of the population (Isoa & Sarkar, 2022). Given the significance of calcium for overall health, it is imperative to ascertain the optimal daily intake for adults and assess the shortfall in consumption compared to recommended guidelines. Additionally, it underscores the importance of investigating current calcium consumption levels among diverse populations to identify deficiencies and potential health implications. By addressing these gaps in knowledge, policymakers, healthcare professionals, …

Constructive Instability And Operation Unified Protector: The Destruction Of The United States-Led World-System, Devin Bryant Gillen

Electronic Theses, Projects, and Dissertations

In 2011, NATO ended the 42-year-long rule of Libya’s Muammar Gaddafi, and plunged the country into over a decade of unending strife, while an arc of crisis emanating from Libya struck much of the region. This study examines the United States' geostrategic approach in the Libyan intervention to illustrate the dialectic intersectional relationships between processes of globalization, American hegemony over the world-system, and American foreign policy in the post-Cold War period (1992-2024) with consideration to world-systems analysis to characterize the United States post-Iraq warfighting strategy in Libya as an adaptation of the purposeful destabilization of Afghanistan and cultivation of an …

The Link Between Classroom Diversity And Academic Advancements, Mary Kuik

Masters Projects

Racially diverse classrooms are not being taught in racially diverse ways, adding to an ever-growing academic gap for students of color. Various studies have pointed to several root causes to this issue, including a lack of representation, bias, inequitable discipline, poor curriculum, and socioeconomic disparity. Due to these causes, students of color are projected to be less successful in state testing and school overall, less likely to obtain a higher education, more likely to be disciplined, more likely to feel a detachment to historical content in the classroom, and more likely to feel a social disconnect from their peers. All …

Insulin Resistance In Women Correlates With Chromatin Histone Lysine Acetylation, Inflammatory Signaling, And Accelerated Aging, Christina Vidal, Jackelyn Alva-Ornelas, Nancy Zhuo Chen, Parijat Senapati, Jerneja Tomsic, Vanessa Myriam Robles, Cristal Resto, Nancy Sanchez, Angelica Sanchez, Terry Hyslop, Nour Emwas, Dana Aljaber, Nick Bachelder, Ernest Martinez, David Ann, Veronica Jones, Robert Winn, Lucio Miele, Augusto Ochoa, Eric Dietze, Rama Natarajan, Dustin Schones, Victoria Seewaldt

Kimmel Cancer Center Faculty Papers

BACKGROUND: Epigenetic changes link medical, social, and environmental factors with cardiovascular and kidney disease and, more recently, with cancer. The mechanistic link between metabolic health and epigenetic changes is only starting to be investigated. In our in vitro and in vivo studies, we performed a broad analysis of the link between hyperinsulinemia and chromatin acetylation; our top "hit" was chromatin opening at H3K9ac.

METHODS: Building on our published preclinical studies, here, we performed a detailed analysis of the link between insulin resistance, chromatin acetylation, and inflammation using an initial test set of 28 women and validation sets of 245, 22, …

Increased Risk Of Cutaneous T-Cell Lymphoma Development After Dupilumab Use For Atopic Dermatitis, Jenna Mandel, Jaanvi Mehta, Ramsay Hafer, Mahaa Ayub, Faria Nusrat, Henry Yang, Pierluigi Porcu, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

There have been several reports of dupilumab use and the development of CTCL; however, the risk of CTCL development has not been adequately evaluated at the population level. The objective of this study is to determine whether dupilumab administration for AD is associated with an increased risk of developing CTCL and to identify at-risk populations within this group. This retrospective cohort study used TriNetX, a deidentified medical record database including over 107 million patients, to identify eligible patients. Treatment and control groups were evaluated for the development of CTCL. Patients of any age with a documented diagnosis of AD were …

The Moderating Role Of Cost And Convenience On The Relationship In The Utaut Model To Adopt E- Payment Services, Essia Ries Ahmed, Brahim Zirari, Imane Tabet Derraz

Journal of International Technology and Information Management

Many emerging economies are on the brink of a major digital revolution as a result of the disruptive and game-changing wave of digitization that aims to create a financial ecosystem that will make the transition from a cash-based economy to a cashless (digital) economy the easiest way by making reliable and secure networks, Seamless payment solutions, ensuring large transactions at lightning speeds are a reality. Most studies using UTAUT are cross-sectional, capturing data at a single point in time. Longitudinal studies are needed to observe changes in behavioural intention and actual adoption of e-payment services over time, particularly in response …

Health Professional Regulation And Provision Of Quality Health Services; Cross Sectional Analysis Of Private Health Care Providers In Wajir County, Kenya, Ali Ahmed Mohamed Qadar, Wanja Mwaura-Tenambergen, Eunice Muthoni, Luke Wahome Kinyua

Population Health, East Africa

Background: Health professional regulatory bodies oversee and enforce standards in healthcare to safeguard patient safety and prevent harm. However, international consistency in these regulations remains limited. The Kenya health sector relies on various bodies to enforce standards among professionals and institutions, albeit constrained by financial and human resources that hinder effective oversight. This study aimed to assess how regulatory practicessuch as licensing, training oversight, inspection of practice, and quality assurance mechanisms- affect the quality of healthcare provided by private providers.

Methods: The study targeted 108 healthcare providers from 36 private health facilities, primarily nurses and clinical officers. A sample of …

In This Issuereview Articleoriginal Articlecase Report

Saudi Medical Journal

No abstract provided.

Specific Association Of Mthfd1 Expressions With Small Cell Lung Cancer Development And Chemoradiotherapy Outcome, Yujia Hao, Ruichun Lu, Ying Guo, Pengtao Bao

Saudi Medical Journal

Objectives: To identify biomarkers that can discriminated small cell lung cancer (SCLC) from non-SCLC (NSCLC), and explore their association with the prognosis of SCLC under chemoradiotherapy. Methods: The GSE40275 dataset was used to identify potential targets in SCLC. There were 196 patients of lung cancer (LC) in cohort 1 of this study. MTHFD1 levels in tissues were determined by immunohistochemistry assay in cohort 1. Lung cancer patients who were all underwent local chemoradiotherapy (CRT) were included in cohort 2, and the association of MTHFD1 levels with CRT treatment outcome were determined in cohort 2. Cell experiments were used to determine …

The Effect Of Injectable Platelet-Rich Fibrin In Combination With Autogenous Bone Grafts On Bone Healing In An Ovariectomized Osteoporotic Rat Model With Critical-Sized Defects, Mustafa C. Durmuşlar, Elif A. Gülşen, Kemal A. Bayburt, Umut Ballı, Mert Ocak, Ayşegül Fırat, Elham B. Zırh, Hakan H. Çelik

Saudi Medical Journal

Objectives: To assess the impact of autogenous graft materials, including autogenous bone graft (ABG) and injectable platelet-rich fibrin (I-PRF) clots, on bone defect regeneration in ovariectomized osteoporotic rats. Methods: Wistar rats (6-8 weeks old) were ovariectomized, and surgery began after 8 weeks. A 5-mm defect was created bilaterally in the parietal bones of 16 rats, which were divided into 4 groups. Group A (blank) had untreated defects; group B had defects filled with 0.1 ml of I-PRF, group C had defects filled with 0.1 ml of ABG, and group D had defects filled with a combination of 0.1 ml each …

Dermatological Conditions In The Intensive Care Unit At A Tertiary Care Hospital In Riyadh, Saudi Arabia, Ghida S. Altammami, Sarah K. Alswayed, Mohammed I. Aljasser, Rayan A. Alkhodair

Saudi Medical Journal

Objectives: To evaluate the various skin conditions diagnosed in intensive care unit (ICU) patients. Methods: This is a descriptive retrospective study of all adults, pediatric, and neonatal patients who were admitted to the ICU and had a dermatological manifestation during hospital stay or patients who had dermatological condition that requires ICU admission. All skin conditions were categorized and analyzed. Results: A total of 344 ICU patients with 365 different dermatological conditions were included in the study. The age of patients ranged from less than 1-96 years, with a mean age of 43.6±30.1 years. Of the patients, 189 (54.9%) were males. …

Nearly 1.8 Billion Adults At Risk Of Disease From Not Doing Enough Physical Activity

Saudi Medical Journal

No abstract provided.

Assessment Of Ferritin And Lead Levels In Children Living In An Informal Urban Settlement In Kenya, Geoffrey Omuse, Daniel Maina, Maureene Ondayo, Stanley Onyango, Syama Sinuff, Alex Mugo, Pauline Samia, William Macharia

Pathology, East Africa

Background: Childhood lead exposure from recycling used lead-acid batteries (ULAB) in unregulated areas is a significant cause of lead toxicity, particularly in low and middle-income countries. This study aimed to assess the proportion of children with increased blood lead levels (BLLs) in an informal settlement where ULAB recycling occurs.

Methodology: This was a descriptive study conducted in Nairobi county, Kenya. Children aged 6 months to 7 years were recruited after obtaining written informed consent, completion of a questionnaire and collection of samples for complete blood count, ferritin, and lead analysis.

Results: Out of 215 children, 17 (8.0%) had BLLs ≥ …

Checklist For Reproducibility Of Deep Learning In Medical Imaging, Mana Moassefi, Yashbir Singh, Gian Marco Conte, Bardia Khosravi, Pouria Rouzrokh, Sanaz Vahdati, Nabile Safdar, Linda Moy, Felipe Kitamura, Amilcare Gentili, Paras Lakhani, Nina Kottler, Safwan Halabi, Joseph Yacoub, Yuankai Hou, Khaled Younis, Bradley Erickson, Elizabeth Krupinski, Shahriar Faghani

Department of Radiology Faculty Papers

The application of deep learning (DL) in medicine introduces transformative tools with the potential to enhance prognosis, diagnosis, and treatment planning. However, ensuring transparent documentation is essential for researchers to enhance reproducibility and refine techniques. Our study addresses the unique challenges presented by DL in medical imaging by developing a comprehensive checklist using the Delphi method to enhance reproducibility and reliability in this dynamic field. We compiled a preliminary checklist based on a comprehensive review of existing checklists and relevant literature. A panel of 11 experts in medical imaging and DL assessed these items using Likert scales, with two survey …

Seizure: Febrile, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Wired For Success: A Neurobiological Approach To Improving The Academic Outcomes Of Middle School Boys, Allison Emery

University Honors Theses

Male accomplishment in scholastic settings has been declining globally for the last decade, leading to long-term consequences for boys and men. Possible neurobiological underpinnings of the gender gap in education are discussed in this literature review. While male and female differences have, in the past, largely been considered socialized, recent science also confirms neurobiological variances between male and female development. These distinctions are assessed for their potential ties to the decline in male academic success, and are correlated to classroom practices, strategies and interventions meant to increase boys' engagement and performance.

Hold Tightly To The Human Touch, Michelle C. Dziurgot Dds

The Journal of the Michigan Dental Association

In this editorial, Dr. Dziurgot reflects on the diminishing human interaction in various services, from ordering food to medical appointments. The editorial emphasizes the importance of maintaining personal communication in dentistry, arguing that patient care should remain personalized and compassionate. The author reminisces about the personalized service of the past, stressing the need for dentists to engage directly with patients, understand their unique needs, and provide a welcoming environment. The piece calls for a return to human touch in professional practices, despite the convenience of modern technology.

Dentistry And The Law: Don’T Overlook Corporate Transparency Act Compliance, Daniel Schulte Jd

The Journal of the Michigan Dental Association

Under the Corporate Transparency Act (CTA), entities existing as of January 1, 2024, must report beneficial ownership to FinCEN by December 31, 2024. Beneficial owners include those with 25% ownership or substantial control. Required information includes legal name, birthdate, address, and ID details. Non-compliance can result in severe civil and criminal penalties. Exceptions may apply for tax-exempt entities and large companies. Legal challenges to the CTA are ongoing, but compliance is advised.

The New Professional: Mastering Those Awkward Moments With Patients, Amrita Patel Dds

The Journal of the Michigan Dental Association

Navigating awkward moments in a dental office is essential for positive patient experiences. Establish rapport with patients, use active listening, and avoid jargon. Prepare for common scenarios, communicate clearly, and address fears. Stay calm with difficult questions and provide honest answers. Train staff through role-play and feedback, and cultivate a positive, empathetic environment. Regularly solicit patient feedback to improve. These strategies ensure patients feel valued and supported.

Mda Foundation Mission Of Mercy: Transforming Lives, Relieving Pain, Anne Berquist

The Journal of the Michigan Dental Association

The MDA Foundation's Mission of Mercy (MOM) dental clinic in Flint provided free dental care to 659 patients over June 14-15, delivering 6,678 procedures valued at $1,156,285. The 120-chair clinic, set up by volunteers, saw patients from 35 Michigan counties and neighboring states. Patients, many of whom queued overnight, received an average of ten procedures each. Volunteers, including retired dentists, performed a wide range of services, from cleanings to complex surgeries. Translators were available to assist non-English speakers, and patients were informed about ongoing free or reduced-cost care options. The event, supported by local donations and community services, will continue …