Digital Commons Network^™

Association Between Expedited Review Designations And The Us Or Global Burden Of Disease For Drugs Approved By The Us Food And Drug Administration, 2010–2019: A Cross-Sectional Analysis, Matthew J. Jackson, Gregory Vaughan, Fred D. Ledley

Natural & Applied Sciences Faculty Publications

Pharmaceutical innovation can contribute to reducing the burden of disease in human populations. This research asks whether products approved by the US Food and Drug Administration (FDA) from 2010 to 2019 and expedited review programmes incentivising development of products for serious disease were aligned with the US or global burden of disease.

Preventing Orthopedic Implant Associated Biofilm Infections Using Transition Metal Complex Laminated Bioactive Implants, Sowndarya J

Theses and Dissertations

Orthopedic implants are medical devices employed to repair the damaged structure and function of an injured musculoskeletal system. It helps millions of people suffering from bone fractures and arthroplasty. The increased use of orthopedic implants has given rise to implant-associated biofilm infections. Biofilm-mediated Implant-associated osteomyelitis (IAO) is a major concern in the medical field, wherein the treatment involves debridement, administration of antibiotics and removal of implants leading to increased cost of treatment.

The keystone bacterial pathogens involved in orthopedic implant-associated infections are Staphylococcus aureus and Acinetobacter baumannii which are members of the ESKAPE pathogens. A. baumannii has gained resistance against …

Project #22: Observation Of Anti-Infective Use In Esophageal Perforations, Emma Kabalka, Courtney Hooten, Allison Bouwma, Kristin Griebe, Carloyn Martz

Quality Expo 2024

Introduction: Esophageal perforations (EPs) are a tear of the esophageal mucosal and muscle layers, posing infection risks, due to gastric contents in the thoracic space. This rare disease state has many causes and has a mortality rate of 13.3%. Diagnosis is challenging due to vague symptoms, leading to delayed treatment Prognosis worsening significantly after 24 hours. Treatment involves surgery, endoscopy, and antibiotics. There is no standardized institutional or national guidance, highlighting the need to assess current practices.

Project #21: Leveraging Stewardship To Promote Ceftriaxone Use In Severe Infections With Low- And No-Risk Ampc Enterobacterales, Megan Hardy, Rachel Kenney, Amy Beaulac, Tricia Stein, Erin Eriksson, Vivek Kak, Asgar Boxwalla, Shaina Vincent, Nasir Husain, Anita B. Shallal, Robert Tibbetts, Kathy Callahan, Allison Weinmann, Geehan Suleyman, Michael Veve

Quality Expo 2024

Aim: To implement and evaluate the impact of a stewardship intervention on the antibiotic treatment of severe infections due to low- and no-risk Enterobacterales. The historical standard of care for the treatment of infections due to these organisms was broad-spectrum intravenous antibiotic therapy with cefepime or a carbapenem such as ertapenem or meropenem. More recent evidence suggests that ceftriaxone, a narrower spectrum antibiotic, is an appropriate choice. Therefore, we aimed to change prescribing practices across Henry Ford Health hospitals to use narrower spectrum therapy to achieve the same patient outcomes.

Preliminary Investigation Of Differences In Host Mitochondria Membrane Potential During Toxoplasma Gondii Infection, Bryan L. Ortega

USF Tampa Graduate Theses and Dissertations

Toxoplasma gondii is an obligate intracellular protozoan with a broad host range of hosts, including various warm-blooded mammals, including humans. While infections can often be asymptomatic in immunocompetent individuals, they can pose significant risks to those who are immunocompromised, as well as pregnant women. Toxoplasmosis represents a significant burden on public health in the United States, with over 800,000 annual infections reported, often leading to severe complications such as symptomatic eye disease and congenital infections. Recent attention has developed regarding its potential association with human neuropathies such as Alzheimer's disease, dementia, and mood disorders. This project investigated differences in host …

Draft Genome Sequences Of Pseudomonas Strains Zfem001–005 Isolated From The Intestine Of Larval Zebrafish Danio Rerio, Sabona B Simbassa, Justin Clark, Keiko Salazar, Anthony Maresso, Anne-Marie Krachler

Faculty, Staff and Student Publications

Here, we report the draft genome sequences of Pseudomonas strains zfem001–005, five isolates from the intestinal microbiota of healthy larval zebrafish Danio rerio at a developmental age of 7 days post fertilization. The isolates have been identified as Pseudomonas sediminis, Pseudomonas japonica, Pseudomonas otitidis, Pseudomonas sichuanensis, and Pseudomonas tohonis, respectively.

Medical Staff Topics, 1993 February, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical Staff Topics: A Newsletter of the St. Luke's Medical Centre Staff". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. This issue also includes information on continuing education opportunities, a current map of the medical center, and a staff calendar.

Medical Staff Topics, 1993 August/September, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical Staff Topics: A Newsletter of the St. Luke's Medical Centre Staff". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates.

This is a scanned photocopy of this issue. If you have an original of this issue, please contact Advocate Health - Midwest Library

Mental Health, Chronic And Infectious Conditions Among Pregnant Persons In Us State Prisons And Local Jails 2016-2017., Caitlin A Hendricks, Karissa M Rajagopal, Carolyn B Sufrin, Camille Kramer, Monik C Jiménez

Cooper Medical School of Rowan University Departmental Research

BACKGROUND: Pregnant individuals in incarcerated settings have unique healthcare needs. Rates of mental health, infectious diseases, and chronic disease are higher among nonpregnant incarcerated women compared with those who are not, but the prevalence of these conditions among pregnant people in custody has not been documented.

OBJECTIVES: The objective of this study is to describe the prevalence of metabolic, infectious, and mental health conditions in pregnant people to identify the medical needs of high-risk pregnancies in US state prisons and local jails.

STUDY DESIGN: This was a prospective epidemiologic surveillance of a convenience sample of state prisons (n = …

Intouch Week Of March 11, 2024, New York Medical College

InTouch

• Dr. Kenneth Knapp Named Chair of Department of Public Health
• Dr. Mitchell Cairo Secures $2.6M FDA Grant for Infant CMV Infection Research
• Department of Radiation Medicine Enrolls First Patient in Nation in Prostate Cancer Clinical Trial
• NYMC and Regeneron Debut Neighborhood Science Seminar Series
• NYMC Annual Days of Giving Set for March 26 and 27
• LCME Element of the Week
• Department Spotlight: The Office of Academic Excellence Elevates Student Achievement
• Dr.P.H. Candidate Advocates for Long Term Care Through the Media

Hands-On Partnership To Improve Intraoperative Hand Hygiene, Kimberly Mitchell, Anastasia Meyers, Jacob Schermetzler

Nursing

No abstract provided.

18f-Fdg Pet/Ct And Radiolabeled Leukocyte Spect/Ct Imaging For The Evaluation Of Cardiovascular Infection In The Multimodality Context: Asnc Imaging Indications (Asn I2) Series Expert Consensus Recommendations From Asnc, Aats, Acc, Aha, Ase, Eanm, Hrs, Idsa, Scct, Snmmi, And Sts, Jamieson M Bourque, Ulrika Birgersdotter-Green, Paco E Bravo, Ricardo P J Budde, Wengen Chen, Vivian H Chu, Vasken Dilsizian, Paola Anna Erba, Cesia Gallegos Kattan, Gilbert Habib, Fabien Hyafil, Yiu Ming Khor, Jaimie Manlucu, Pamela Kay Mason, Edward J Miller, Marc R Moon, Matthew W Parker, Gosta Pettersson, Robert D Schaller, Riemer H J A Slart, Jordan B Strom, Bruce L Wilkoff, Adam Williams, Ann E Woolley, Brittany A Zwischenberger, Sharmila Dorbala

Faculty, Staff and Students Publications

This document on cardiovascular infection, including infective endocarditis, is the first in the American Society of Nuclear Cardiology Imaging Indications (ASNC I2) series to assess the role of radionuclide imaging in the multimodality context for the evaluation of complex systemic diseases with multi-societal involvement including pertinent disciplines. A rigorous modified Delphi approach was used to determine consensus clinical indications, diagnostic criteria, and an algorithmic approach to diagnosis of cardiovascular infection including infective endocarditis. Cardiovascular infection incidence is increasing and is associated with high morbidity and mortality. Current strategies based on clinical criteria and an initial echocardiographic imaging approach are effective …

Cns Impact As A Sepsis Coordinator, Emily Selby

Nursing

No abstract provided.

Primary Healthcare Providers' Knowledge On The Early Detection Of Biliary Atresia, Rendi Aji Prihaningtyas, Bagus Setyoboedi, Ni Nyoman Metriani Nesa, Melinda Masturina, Martono Tri Utomo, Sjamsul Arief

Folia Medica Indonesiana

Highlights: 1. An evaluation is necessary to verify that the knowledge of healthcare providers is sufficient for the early detection of biliary atresia. 2. It is crucial to promote education on prolonged jaundice to ensure early detection of biliary atresia in primary health facilities, as some primary healthcare providers have insufficient knowledge on the subject. Abstract Primary healthcare providers frequently fail to recognize biliary atresia because it closely mimics physiological jaundice. Early detection plays an important role in ensuring the optimal treatment of biliary atresia. Delays in referring to biliary atresia cases remain a problem around the world. The objective …

The Use Of Comics As A Tuberculosis Learning Medium For Junior High School Students, Budi Utomo, Widati Fatmaningrum, Sulistiawati, Shifa Fauziyah, Teguh Hari Sucipto, Chan Chow Khuen

Folia Medica Indonesiana

Highlights: 1. Comics centered around tuberculosis offer a novel method tailored for specific audiences, specifically children or those of school age, to learn about the disease. 2. The tuberculosis comics feature the etiology, prevention, and treatment of tuberculosis conveyed through their unique design. 3. Comics can be an innovative promotional method to support the preventive campaign against tuberculosis. Abstract As a tropical country, Indonesia continues to grapple with the prevalence of tuberculosis. This study conducted by the Department of Public Health and Preventive Medicine at Universitas Airlangga, Surabaya, Indonesia, presented a novel approach to prevent tuberculosis through measures tailored to …

Factors That Influence Stunting In The Maratua District Of Berau, Indonesia, Risa Haryati Tambunan, Elis Nurbaeti

Folia Medica Indonesiana

Highlights: 1. This study investigated the factors contributing to stunting in a remote area, which has not received sufficient attention from key stakeholders. 2. The findings of this study can serve as a reference for the government in addressing stunting through intervention strategies that incorporate paternal roles to improve children's nutritional status. Abstract Stunting is a community health problem with significant impacts. The estimated prevalence rate of stunting was 24.4% in Indonesia and 25.7% in the Berau Regency. Stunting is a growth disorder caused by chronic malnutrition during the first 1,000 days of life. It is characterized by a height-for-age …

The Etiology Of Paralytic Strabismus At An Indonesian Tertiary Hospital From 2017 To 2022, Aulia Rachma Nur Azizah, Rozalina Loebis, Hanik Badriyah Hidayati, Indri Wahyuni, Lely Retno Wulandari

Folia Medica Indonesiana

Highlights: 1. This study investigated the etiology of paralytic strabismus, a condition that requires further research to prevent its incidence, particularly in adults. 2. The findings of this study provided valuable insight into the primary etiology of paralytic strabismus and its underlying factors. Abstract Paralytic strabismus is the most common cause of adult-onset strabismus. It can result from paralysis of the third, fourth, or sixth cranial nerves, either separately or in combination, which are responsible for innervating the ocular motor muscles. Paralysis of these cranial nerves occurs due to congenital disorders, neoplasms, trauma, intracranial processes, idiopathic diseases, and other causes. …

The Effect Of The Covid-19 Pandemic On The Environmental Perceptions Of College Students, Sydney H. Kaylor

USF Tampa Graduate Theses and Dissertations

In this study, the environmental perception changes in college students during the COVID-19 pandemic were investigated. During the almost worldwide lockdown between March and December 2020, many students experienced dramatic changes in their socioeconomic life that have affected their well-being, ability to learn, and environmental perceptions. Students were sent home from college campuses, many businesses were shut down, and changes were seen in the environment throughout the world. The many industries and businesses that were shut down decreased the pollution that was in the atmosphere, in our water, and on the land. In many places, lockdown policies lead to improved …

Bacteriophage Therapy For The Treatment Of Mycobacterium Tuberculosis Infections In Humanized Mice, Fan Yang, Alireza Labani-Motlagh, Jose Alejandro Bohorquez, Josimar Dornelas Moreira, And Additional Authors

School of Medicine Faculty Publications and Presentations

The continuing emergence of new strains of antibiotic-resistant bacteria has renewed interest in phage therapy, however, there has been limited progress in applying phage therapy to multi-drug resistant Mycobacterium tuberculosis (Mtb) infections. In this study, we show that bacteriophage strains D29 and DS6A can efficiently lyse Mtb H37Rv in 7H10 agar plates. However, only phage DS6A efficiently kills H37Rv in liquid culture and in Mtb-infected human primary macrophages. We further show in subsequent experiments that, after the humanized mice were infected with aerosolized H37Rv, then treated with DS6A intravenously, the DS6A treated mice showed increased body weight and improved pulmonary …

Analysis Of The Relationship Between Knowledge, Behaviour, Prevention, And Self-Efficacy On The Mental Health Of Athletes During The Covid-19 Pandemic, Fahrial Amiq, Fidia Rizkiah Inayatilah, Prayogi Dwina Angga

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Mental health has become a trending topic during the pandemic. Many athletes have experienced decreased performance during the pandemic, but not a few athletes are able to control their mental health. Objective: The purpose of this study was to examine the relationship between knowledge, preventive behaviour, and self-efficacy on mental health in professional football athletes during the COVID-19 pandemic. This research uses quantitative methods. Methods: This type of research is observational with a cross-sectional study. Eighty professional football athletes were involved in this research. The sampling technique was carried out using a proportional stratified simple random sampling technique.  This …

Analysis Of Invalid Vaccination Dose Administration Among U.S. Children: National Immunization Survey-Child 2011-2020, Alexandria N. Albers

UM Graduate Student Research Conference (GradCon)

The Advisory Committee on Immunization Practices (ACIP) recommends that children receive multiple routine vaccinations to prevent infectious diseases, with most vaccinations requiring multiple doses. Vaccination series have minimum age and interval requirements, and doses provided outside recommended parameters are considered invalid and should be repeated. Our objective was to quantify the number of U.S. children ages 19-35 months who received invalid vaccination doses, those who had invalid vaccinations re-administered, and factors associated with receiving at least one invalid vaccination.

We analyzed provider-verified vaccination records from the 2011-2020 National Immunization Survey-Child to quantify the number of children with invalid vaccinations and …

Revisiting Compassionate Release: The Sentencing Commission’S Compassionate Changes To The 2023 Compassionate Release Policy Statement, Rachel Wilson

Cleveland State Law Review

Compassionate release is a well-established exception to the Sentencing Reform Act’s requirement that a defendant’s sentence not be reduced after its final imposition. The Act requires the Sentencing Commission, through policy statement, to describe “extraordinary and compelling reasons” warranting compassionate release. However, the Sentencing Commission’s failure to convene as a quorum for nearly four years precluded any policy statement updates. In that time, the COVID-19 pandemic and the Bureau of Prisons’ internal issues further complicated the compassionate release process. This Note analyzes the 2023 amendment to the compassionate release policy statement, its potential implications, and suggests additional steps to be …

Identification Of Novel Small Molecule Inhibitors Of Twin Arginine Translocation (Tat) Pathway And Their Effect On The Control Of Campylobacter Jejuni In Chickens, Loïc Deblais, Mary Drozd, Anand Kumar, Janet Antwi, James Fuchs, Rahul Khupse, Yosra A. Helmy, Gireesh Rajashekara

School of Veterinary and Biomedical Sciences: Faculty Publications

Introduction: Control of Campylobacter from farm to fork is challenging due to the frequent emergence of antimicrobial-resistant isolates. Furthermore, poultry production systems are known reservoirs of Campylobacter. The twinarginine translocation (Tat) pathway is a crucial bacterial secretion system that allows Campylobacter to colonize the host intestinal tract by using formate as the main source of energy. However, Tat pathway is also a major contributing factor for resistance to copper sulfate (CuSO₄).

Methods: Since mammals and chickens do not have proteins or receptors that are homologous to bacterial Tat proteins, identification of small molecule (SM) inhibitors …

An Mhealth Intervention To Address Depression And Improve Antiretroviral Therapy Adherence Among Youths Living With Hiv In Uganda: Protocol For A Pilot Randomized Controlled Trial, Proscovia Nabunya, Patricia Cavazos-Rehg, James Mugisha, Erin Kasson, Olive Imelda Namuyaba, Claire Najjuuko, Edward Nsubuga, Lindsey M Filiatreau, Abel Mwebembezi, Fred M Ssewamala

2020-Current year OA Pubs

BACKGROUND: People living with HIV often struggle with mental health comorbidities that lower their antiretroviral therapy (ART) adherence. There is growing evidence that depression treatment may improve ART adherence and result in improved HIV outcomes. Given that mental health services are severely underequipped in low-resource settings, including in Uganda, new solutions to increase access to mental health care and close the treatment gap are urgently needed. This protocol paper presents the Suubi-Mhealth study, which proposed to develop a mobile health (mHealth) intervention for use among Ugandan youths (14-17 years) with comorbid HIV and depression, taking into account their unique contextual, …

Anopheles Population Belonging To Barbirostris Complex In Narathiwat Province And Its Vectorial Status For Human And Simian Malaria, Surasuk Yanmanee, Sunee Seethamchai, Napaporn Kuamsab, Taweesak Tia, Somchai Jongwutiwes, Chaturong Putaporntip

Chulalongkorn Medical Journal

Background: Besides well-perceived species of Plasmodium infecting humans, at least four simian malaria species including P. knowlesi, P. cynomolgi, P. inui and P. fieldi have been incriminated in human infections in Thailand. The vectors of simian malaria in this country have been recently identified to be Anopheles latens and An. introlatus.

Objectives: To address whether mosquitoes in Barbirostris complex in Narathiwat Province could vector simian malaria and to analyze species distribution of Anopheles in this complex from the sampled population.

Methods: A total of 115 mosquitoes from Sukhirin and Waeng Districts in Narathiwat Province morphologically assigned to …

Pulmonary Rehabilitation For Critically Ill Elderly Patients With Covid-19 In Thailand: A Report Of Two Cases, Thitapa Issaragraisin, Jirapa Champaiboon

Chulalongkorn Medical Journal

The vast majority of patients exposed to coronavirus (COVID-19) were likely to face complications during their recovery from coronavirus. The first case was an old Thai woman presented with severe COVID-19 pneumonia. The other was an old Thai man presented with COVID-19 with complications such as acute respiratory distress syndrome, hyperglycemia, thrombocytopenia, right tension pneumothorax with recurrent pneumothorax and monoparesis. These two cases presented the role of physical therapy for critically ill elderly patients with chest complications from COVID-19.

Diagnosis And Treatment Of Helicobacter Pylori, Erin Raspet

Pacific Journal of Health

Helicobacter pylori is a widespread infectious disease most commonly associated with gastritis, peptic ulcer disease, and gastric cancer. The ability of this organism to influence immune function has been associated with a proinflammatory state that has been associated with several other conditions that can lead to significant mortality and morbidity. Treatment is possible with antibiotic regimens, however, increasing resistance requires treatment be informed by susceptibility information followed by a test of cure to ensure eradication of the infection. Given the global burden of this infection, it is important for providers to appropriately identify, diagnosis, and treat this condition to reduce …

Detection Of Pathogenic Leptospira Spp. By Rpa-Nalfia Targeting Lipl32 Gene, Nattachai Srisawat

Chulalongkorn Medical Journal

Background: Lack of available sensitive point-of-care tests is one of the key challenges limiting the early point-of-care diagnosis of leptospirosis.Previously, a Recombinase Polymerase Amplification (RPA) and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 12a (CRISPR/Cas12a) lipL32 detection platform with high sensitivity and specificity was developed. However, its turnaround time is between one and two hours, and two reactions are required.

Objective: To develop the RPA in combination with a nucleic acid lateral flow immunoassay (NALFIA) detection platform to reduce the turnaround time and make it a one-step reaction.

Methods: RPA combined with nucleic acid lateral flow immunoassay (NALFIA) detection …

Rapid Measurement Of Hemoglobin-Oxygen Dissociation By Leveraging Bohr Effect And Soret Band Bathochromic Shift, Zoe Sekyonda, Ran An, Utku Goreke, Yuncheng Man, Karamoja Monchamp, Allison Bode, Qiaochu Zhang, Ozan Akkus, Umut A. Gurkan

Faculty Scholarship

Oxygen (O2) binds to hemoglobin (Hb) in the lungs and is then released (dissociated) in the tissues. The Bohr effect is a physiological mechanism that governs the affinity of Hb for O2 based on pH, where a lower pH results in a lower Hb-O2 affinity and higher Hb-O2 dissociation. Hb-O2 affinity and dissociation are crucial for maintaining aerobic metabolism in cells and tissues. Despite its vital role in human physiology, Hb-O2 dissociation measurement is underutilized in basic research and in clinical laboratories, primarily due to the technical complexity and limited throughput of existing methods. We present a rapid Hb-O2 dissociation …

Implementing Services For Pediatric Cystic Fibrosis Treatment In A Community Hospital., Paige Grube, Heather Nichols, Sarah Ferrell Pharmd, Denise Gilham Pnp, Allyson Gaylor Pharmd, Bcpps, Karen Dunkelberger Bs Pharm, Mshi, Cpps

Pharmacy Residency

This project aimed to describe how the pharmacy department prepared to care for pediatric patients with cystic fibrosis, a new population being cared for at the institution.

PURPOSE: Our community hospital was recently charged with providing care for pediatric people with cystic fibrosis (PwCF). Pediatric PwCF generally need a higher level of care than is required by other pediatric patients cared for at our institution. This project aimed to prepare the pharmacy department to care for this specialized population safely and efficiently.

SUMMARY: The implementation process was divided into 3 phases to accomplish the larger purpose. These phases were as …