Digital Commons Network^™

Effect Of Neutralizing Monoclonal Antibody Treatment On Early Trajectories Of Virologic And Immunologic Biomarkers In Patients Hospitalized With Covid-19, Tomas O Jensen, Greg A Grandits, Mamta K Jain, Thomas A Murray, Birgit Grund, Kathryn Shaw-Saliba, Michael A Matthay, Mahsa Abassi, Magdalena Ardelt, Jason V Baker, Peter Chen, Robin L Dewar, Anna L Goodman, Timothy J Hatlen, Helene C Highbarger, Mark Holodniy, Perrine Lallemand, Sylvain Laverdure, Bradley G Leshnower, David Looney, Charalampos D Moschopoulos, Henry Mugerwa, Daniel D Murray, Eleftherios Mylonakis, Stephanie Nagy-Agren, M Tauseef Rehman, Adam Rupert, Randy A Stevens, Stuart Turville, Amy Weintrob, Katherine Wick, Jens Lundgren, Emily R Ko, Activ-3/Tico Study Group

Faculty, Staff and Student Publications

BACKGROUND: Neutralizing monoclonal antibodies (nmAbs) failed to show clear benefit for hospitalized patients with coronavirus disease 2019 (COVID-19). Dynamics of virologic and immunologic biomarkers remain poorly understood.

METHODS: Participants enrolled in the Therapeutics for Inpatients with COVID-19 trials were randomized to nmAb versus placebo. Longitudinal differences between treatment and placebo groups in levels of plasma nucleocapsid antigen (N-Ag), anti-nucleocapsid antibody, C-reactive protein, interleukin-6, and D-dimer at enrollment, day 1, 3, and 5 were estimated using linear mixed models. A 7-point pulmonary ordinal scale assessed at day 5 was compared using proportional odds models.

RESULTS: Analysis included 2149 participants enrolled between …

Interferons In Viral Infections, Pracheta Sengupta, Saurabh Chattopadhyay

Markey Cancer Center Faculty Publications

No abstract provided.

New Hard Tick (Acari: Ixodidae) Reports And Detection Of Rickettsia In Ticks From Sierra Nevada De Santa Marta, Colombia, Ángel Oviedo, Miguel M. Rodríguez, Fernando S. Flores, Lyda R. Castro

Harold W. Manter Laboratory of Parasitology: Library Materials

The Sierra Nevada de Santa Marta (SNSM), located in northern Colombia, is considered a geographical island with high levels of biodiversity and endemism. However, little is known about tick species and their associated microorganisms at the SNSM. In this study we sampled host-seeking ticks in areas of the town of Minca within the SNSM. We collected 47 ticks identified as Amblyomma pacae, Amblyomma longirostre, Amblyomma ovale, Amblyomma mixtum, Haemaphysalis juxtakochi, Ixodes sp. cf. Ixodes affinis and Ixodes sp. Of these ticks, we tested for Rickettsia spp. by amplifying the gltA, SCA1, and 16S rRNA genes via PCR. Rickettsia amblyommatis …

Btn1a1 Is A Novel Immune Checkpoint Mutually Exclusive To Pd-L1, Young-Seung Kim, Seung-Hoon Lee, Andrew H Park, Chunai Wu, Bong-Ki Hong, Hyunjin Jung, Steven H Lin, Stephen S Yoo

Faculty, Staff and Student Publications

BACKGROUND: While Programmed cell death protein 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) blockade is a potent antitumor treatment strategy, it is effective in only limited subsets of patients with cancer, emphasizing the need for the identification of additional immune checkpoints. Butyrophilin 1A1 (BTN1A1) has been reported to exhibit potential immunoregulatory activity, but its ability to function as an immune checkpoint remains to be systematically assessed, and the mechanisms underlying such activity have yet to be characterized.

METHODS: BTN1A1 expression was evaluated in primary tumor tissue samples, and its ability to suppress T-cell activation and T cell-dependent tumor clearance was examined. …

Effect Of Neutralizing Monoclonal Antibody Treatment On Early Trajectories Of Virologic And Immunologic Biomarkers In Patients Hospitalized With Covid-19, Tomas O Jensen, Greg A Grandits, Mamta K Jain, Thomas A Murray, Birgit Grund, Kathryn Shaw-Saliba, Michael A Matthay, Mahsa Abassi, Magdalena Ardelt, Jason V Baker, Peter Chen, Robin L Dewar, Anna L Goodman, Timothy J Hatlen, Helene C Highbarger, Mark Holodniy, Perrine Lallemand, Sylvain Laverdure, Bradley G Leshnower, David Looney, Charalampos D Moschopoulos, Henry Mugerwa, Daniel D Murray, Eleftherios Mylonakis, Stephanie Nagy-Agren, M Tauseef Rehman, Adam Rupert, Randy A Stevens, Stuart Turville, Amy Weintrob, Katherine Wick, Jens Lundgren, Emily R Ko

Faculty, Staff and Student Publications

BACKGROUND: Neutralizing monoclonal antibodies (nmAbs) failed to show clear benefit for hospitalized patients with coronavirus disease 2019 (COVID-19). Dynamics of virologic and immunologic biomarkers remain poorly understood.

METHODS: Participants enrolled in the Therapeutics for Inpatients with COVID-19 trials were randomized to nmAb versus placebo. Longitudinal differences between treatment and placebo groups in levels of plasma nucleocapsid antigen (N-Ag), anti-nucleocapsid antibody, C-reactive protein, interleukin-6, and D-dimer at enrollment, day 1, 3, and 5 were estimated using linear mixed models. A 7-point pulmonary ordinal scale assessed at day 5 was compared using proportional odds models.

RESULTS: Analysis included 2149 participants enrolled between …

Outpatient Covid-19 Convalescent Plasma Recipient Antibody Thresholds Correlated To Reduced Hospitalizations Within A Randomized Trial, Han-Sol Park, Anna Yin, Caelan Barranta, John S Lee, Christopher A Caputo, Jaiprasath Sachithanandham, Maggie Li, Steve Yoon, Ioannis Sitaras, Anne Jedlicka, Yolanda Eby, Malathi Ram, Reinaldo E Fernandez, Owen R Baker, Aarthi G Shenoy, Giselle S Mosnaim, Yuriko Fukuta, Bela Patel, Sonya L Heath, Adam C Levine, Barry R Meisenberg, Emily S Spivak, Shweta Anjan, Moises A Huaman, Janis E Blair, Judith S Currier, James H Paxton, Jonathan M Gerber, Joann R Petrini, Patrick B Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Valerie C Cluzet, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L Hammitt, Catherine G Sutcliffe, Donald N Forthal, Martin S Zand, Edward R Cachay, Jay S Raval, Seble G Kassaye, Christi E Marshall, Anusha Yarava, Karen Lane, Nichol A Mcbee, Amy L Gawad, Nicky Karlen, Atika Singh, Daniel E Ford, Douglas A Jabs, Lawrence J Appel, David M Shade, Bryan Lau, Stephan Ehrhardt, Sheriza N Baksh, Janna R Shapiro, Jiangda Ou, Yu Bin Na, Maria D Knoll, Elysse Ornelas-Gatdula, Netzahualcoyotl Arroyo-Curras, Thomas J Gniadek, Patrizio Caturegli, Jinke Wu, Nelson Ndahiro, Michael J Betenbaugh, Alyssa Ziman, Daniel F Hanley, Arturo Casadevall, Shmuel Shoham, Evan M Bloch, Kelly A Gebo, Aaron Ar Tobian, Oliver Laeyendecker, Andrew Pekosz, Sabra L Klein, David J Sullivan

Faculty, Staff and Students Publications

BACKGROUND

COVID-19 convalescent plasma (CCP) virus-specific antibody levels that translate into recipient posttransfusion antibody levels sufficient to prevent disease progression are not defined.

METHODS

This secondary analysis correlated donor and recipient antibody levels to hospitalization risk among unvaccinated, seronegative CCP recipients within the outpatient, double-blind, randomized clinical trial that compared CCP to control plasma. The majority of COVID-19 CCP arm hospitalizations (15/17, 88%) occurred in this unvaccinated, seronegative subgroup. A functional cutoff to delineate recipient high versus low posttransfusion antibody levels was established by 2 methods: (i) analyzing virus neutralization–equivalent anti–Spike receptor-binding domain immunoglobulin G (anti-S-RBD IgG) responses in donors …

Risk Assessment Of Blood-Borne Pathogen Exposure For Emergency Responders, Jill A. Ireland

USF Tampa Graduate Theses and Dissertations

Emergency responders face a significant risk of exposure to blood-borne pathogens (BBPs), such as HIV and hepatitis, due to the nature of their work environment. This study investigates this issue utilizing a dual approach of data analysis and online surveys to assess exposure rates, risk perceptions, factors that contribute to risk and prevention practices. In addressing issues ranging from personal protective equipment (PPE) usage to levels of concern surrounding blood and bodily fluid contact, the findings underscore the need for tailored safety measures, comprehensive education, and improved prevention strategies.

The examination of 346 worker's compensation exposure claims highlighted a significant …

The Relationship Between Adverse Childhood Experiences And Juvenile Offender Typology, Aliza Beth Lipman

Dissertations and Theses

Approximately 1 in 5 girls and in 20 boys in the United States are victims of child sexual assault every year. Child sexual assault can lead to multiple negative short term and long-term impacts affecting general health, mental health, interpersonal relationships, socio-economic status, criminal behavior and more. Prevention research focuses on a thorough understanding of the perpetrators of assault and the context surrounding offenses in order to reduce and prevent assault. Within this research, juvenile offenders are perceived as a single homogenous group whereas adult offenders are consistently specified based on offender and offense characteristics. The exploration of the relationship …

Why We Need To Decolonize The Biosciences Curriculum, Lovleen Tina Joshi, Catherine Mansfield, Isaiah J. Ting, Katharine Hubbard

Peninsula Dental School

Bioscience has a history linked to exploitation, colonialism and marginalization. Biology has been dominated by white European perspectives, and pseudoscientific ‘biological’ arguments have been used to justify discrimination and oppression, particularly on the basis of disability and ethnicity. Addressing this legacy within bioscience education is challenging, particularly as many bioscientists are unaware of this history and its on- going influence on the discipline. In this article, we explore what decolonization of the curriculum means within the context of bioscience. To demystify terminology for those new to the subject, we first consider the differences between diversification and decolonization. We then explore …

Knowledge, Attitudes, And Hesitancy To Covid-19 Vaccination Uptake In Nigeria, Dominique U. Mbachie

Walden Dissertations and Doctoral Studies

Vaccine hesitancy is a major global health problem despite their being historically effective at preventing infectious diseases such as tetanus, diphtheria, polio, rabies, pertussis, measles, and yellow fever. It has significantly hampered herd immunity, with a rate of 67% for COVID-19 globally. Vaccine hesitancy is common in underdeveloped nations like Nigeria. Misinformation and rumors may be the foundation of the lower vaccination rates in impacted African nations, particularly Nigeria. Thus, the Nigerian population has primarily remained unvaccinated or hesitant about COVID-19 vaccination uptake. This qualitative study explored the knowledge and attitudes towards hesitancy regarding COVID-19 vaccination uptake in Nigeria. The …

Decolonizing And Diversifying The Biosciences Curriculum – A Practical Guide To Getting Started, Catherine Mansfield, Lovleen Tina Joshi, Isaiah J. Ting, Katharine Hubbard

Peninsula Dental School

To create inclusive bioscience learning environments, we need to challenge the dominance of white European perspectives within our discipline through diversification and decolonization of the curriculum. Bioscientists may be unsure how to start this process or may struggle to see how it is relevant within scientific disciplines. Here, we provide some practical suggestions of how to start with diversification and decolonization. We highlight a published culturally competent curriculum structure that may be of value and give multiple steps towards decolonization. These range from considering terminology, addressing gaps in our own knowledge to learning how to pronounce names from multiple cultures …

Viral Epitope Scanning Reveals Correlation Between Seasonal Hcovs And Sars-Cov-2 Antibody Responses Among Cancer And Non-Cancer Patients, Salum J. Lidenge, Dicle Yalcin, Sydney J. Bennett, Owen Ngalamika, Brenda B. Kweyamba, Chacha J. Mwita, For Yue Tso, Julius Mwaiselage, John T. West, Charles Wood

School of Medicine Faculty Publications

Seasonal coronaviruses (HCoVs) are known to contribute to cross-reactive antibody (Ab) responses against SARS-CoV-2. While these responses are predictable due to the high homology between SARS-CoV-2 and other CoVs, the impact of these responses on susceptibility to SARS-CoV-2 infection in cancer patients is unclear. To investigate the influence of prior HCoV infection on anti-SARS-CoV-2 Ab responses among COVID-19 asymptomatic individuals with cancer and controls without cancers, we utilized the VirScan technology in which phage immunoprecipitation and sequencing (PhIP-seq) of longitudinal plasma samples was performed to investigate high-resolution (i.e., epitope level) humoral CoV responses. Despite testing positive for anti-SARS-CoV-2 Ab in …

Viral Epitope Scanning Reveals Correlation Between Seasonal Hcovs And Sars-Cov-2 Antibody Responses Among Cancer And Non-Cancer Patients, Salum J. Lidenge, Dicle Yalcin, Sydney J. Bennett, Owen Ngalamika, Brenda B. Kweyamba, Chacha J. Mwita, For Yue Tso, Julius Mwaiselage, John T. West, Charles Wood

School of Biological Sciences: Faculty Publications

Seasonal coronaviruses (HCoVs) are known to contribute to cross-reactive antibody (Ab) responses against SARS-CoV-2. While these responses are predictable due to the high homology between SARS-CoV-2 and other CoVs, the impact of these responses on susceptibility to SARS-CoV-2 infection in cancer patients is unclear. To investigate the influence of prior HCoV infection on anti- SARS-CoV-2 Ab responses among COVID-19 asymptomatic individuals with cancer and controls without cancers, we utilized the VirScan technology in which phage immunoprecipitation and sequencing (PhIP-seq) of longitudinal plasma samples was performed to investigate high-resolution (i.e., epitope level) humoral CoV responses. Despite testing positive for anti-SARS-CoV-2 Ab …

Unraveling Trends In Schistosomiasis: Deep Learning Insights Into National Control Programs In China, Qing Su, Cici Xi Chen Bauer, Robert Bergquist, Zhiguo Cao, Fenghua Gao, Yi Hu, Zhijie Zhang

Faculty, Staff and Student Publications

OBJECTIVES: to achieve the ambitious goal of eliminating schistosome infections, the Chinese government has implemented diverse control strategies. This study explored the progress of the 2 most recent national schistosomiasis control programs in an endemic area along the Yangtze River in China.

METHODS: We obtained village-level parasitological data from cross-sectional surveys combined with environmental data in Anhui Province, China from 1997 to 2015. A convolutional neural network (CNN) based on a hierarchical integro-difference equation (IDE) framework (i.e., CNN-IDE) was used to model spatio-temporal variations in schistosomiasis. Two traditional models were also constructed for comparison with 2 evaluation indicators: the mean-squared …

Health Status In An Urban-Dwelling, Subtropical Frog Species (Lithobates Sphenocephalus) And Its Relation To Ranavirus And Hemoparasites, Gabrielle M. Wickersham

USF Tampa Graduate Theses and Dissertations

Urbanization poses significant challenges to wildlife, including amphibians. The present study uses a multi-parameter approach that incorporates veterinary techniques to investigate the current health status of the adult southern leopard frogs (Lithobates sphenocephalus) in Tampa Bay, Florida, amidst urban stressors including nutrient loading, fragmented habitats, and light and noise pollution. Novel values for fluctuating asymmetry (e.g., variation between left and right bilateral traits; FA), body condition (CF), stress (e.g., neutrophil:lymphocyte (N:L) ratio), and inflammation (e.g., neutrophil morphologic abnormalities, parasite load) are reported. I also investigate the relationship of overall health with ranavirus presence and hemoparasite infections. Ranavirus was absent in …

Quality Improvement In Public-Private Partnerships In Low- And Middle-Income Countries: A Systematic Review, Cassandra Iroz, Rohit Ramaswamy, Zulfiqar Bhutta, Paul Barach

College of Population Health Faculty Papers

BACKGROUND: Public-private partnerships (PPP) are often how health improvement programs are implemented in low-and-middle-income countries (LMICs). We therefore aimed to systematically review the literature about the aim and impacts of quality improvement (QI) approaches in PPP in LMICs.

METHODS: We searched SCOPUS and grey literature for studies published before March 2022. One reviewer screened abstracts and full-text studies for inclusion. The study characteristics, setting, design, outcomes, and lessons learned were abstracted using a standard tool and reviewed in detail by a second author.

RESULTS: We identified 9,457 citations, of which 144 met the inclusion criteria and underwent full-text abstraction. We …

The Parthenon, March 13, 2024, Evan Green, Matthew Schaffer, Sarah Davis, Joseph Dicristofaro, Victoria Ware, Abigail Cutlip, Rafael Alfonso, Scott Price, Baylee Parsons, Emma Gallus, Luke Jeffrey

The Parthenon

No abstract provided.

Renewing Products Liability With Semen, Anita Bernstein

DePaul Law Review

No abstract provided.

Medical Staff Topics, 1994 February, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical Staff Topics: A Newsletter of the St. Luke's Medical Centre Staff". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Also included is Issue 53 of "Pharmacy Newsletter", tips on personal financial strategies from the Office of Philanthropy, continuing education opportunities, and a staff calendar. In addition, there is a fact sheet on the Wisconsin Health Information Network (WHIN).

Medical Staff Topics, 1994 July, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical Staff Topics: A Newsletter of the St. Luke's Medical Centre Staff". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Also included is Issue 57 of "Pharmacy Newsletter", Issue 7 of "Quality Quest", photographs from the annual outing, a fact sheet on EMTEK, and a staff calendar.

Medical Staff Topics, 1994 October, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical Staff Topics: A Newsletter of the St. Luke's Medical Centre Staff". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Also included is Issue 60 of "Pharmacy Newsletter", and Information Services Department Customer Services Survey, continuing education opportunities, and a staff calendar.

Medical Staff Topics, 1994 November, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical Staff Topics: A Newsletter of the St. Luke's Medical Centre Staff". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Also included is Issue 61 of "Pharmacy Newsletter", a special insert on new requirement for history and physical exam, and a staff calendar.

Medical Staff Topics, 1994 December, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical Staff Topics: A Newsletter of the St. Luke's Medical Centre Staff". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Also included is a special insert on Vancomycin-Resistant Enterocci (VRE), information on the merger of West Allis Memorial Hospital into Aurora Health Care, continuing education opportunities, and a staff calendar.

Medical Staff Topics, 1995 April, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical Staff Topics: A Newsletter of the St. Luke's Medical Centre Staff". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Also included is Issue 64 of "Pharmacy Newsletter" and a staff calendar.

Medical Staff Topics, 1996 June, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical Staff Topics: A Newsletter of the St. Luke's Medical Centre Staff". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Includes an issue of "Pharmacy Newsletter".

Medical Staff Topics, 1997 December/January, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical Staff Topics: A Newsletter of the St. Luke's Medical Centre Staff". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Includes an issue of "Pharmacy Newsletter" and a special insert on GI Hemorrhage.

Medical Staff Topics, 1997 March/April, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical Staff Topics: A Newsletter of the St. Luke's Medical Centre Staff". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Includes an issue of "Pharmacy Newsletter".

This is the last issue of this publication that the library currently has archived.

Novel Inhibitors To Mmpl3 Transporter Of Mycobacterium Tuberculosis By Structure-Based High-Throughput Virtual Screening And Molecular Dynamics Simulations, Hetanshi Choksi, Justin Carbone, Nicholas J. Paradis, Lucas Bennett, Candice Bui-Linh, Chun Wu

College of Science & Mathematics Departmental Research

Tuberculosis (TB)-causing bacterium Mycobacterium tuberculosis (Mtb) utilizes mycolic acids for building the mycobacterial cell wall, which is critical in providing defense against external factors and resisting antibiotic action. MmpL3 is a secondary resistance nodulation division transporter that facilitates the coupled transport of mycolic acid precursor into the periplasm using the proton motive force, thus making it an attractive drug target for TB infection. In 2019, X-ray crystal structures of MmpL3 from M. smegmatis were solved with a promising inhibitor SQ109, which showed promise against drug-resistant TB in Phase II clinical trials. Still, there is a pressing need to discover more …

Project #31: Reducing Greenhouse Gas Emissions In Jackson: A Cqi Story About The Triumphs Of Science And Collaboration In Changing Clinical Operations, Joshua Goldblatt, Kimberly Finch, Terry A. Ellis, Kannan Suri-Mohanram

Quality Expo 2024

The climate change crisis threatens human health by adversely affecting the spread of infectious disease, malnutrition, mental health, and the displacement of people or communities. The Anesthesiology Performance Improvement and Reporting Exchange (ASPIRE) is a project of the Multicenter Perioperative Outcomes Group (MPOG) Collaborative Quality Initiative (CQI). Their sustainability goal is to help reduce greenhouse gas emissions from anesthesia waste used in the US by optimizing environmentally-safer anesthesia agents and managing fresh gas flow.

Project #25: Putting A Cap On Discharge Antimicrobial Therapy: Evaluation Of A Transitions Of Care Process Through An Electronic Scoring System For Patients With Community-Acquired Pneumonia (Cap) And Chronic Obstructive Pulmonary Disease (Copd), Ana Christine O. Belza-Mai, Jessica Efta, Rachel Kenney, Nancy Macdonald, John Stine, Robert Mccollom, Martin Ratusznik, Nisha Patel

Quality Expo 2024

Problem: Less than 1 in 5 hospitals with monitor antibiotic use at hospital discharge, leading to antibiotic overuse. Antimicrobial Stewardship Program Transition of Care (ASP TOC) is a standard of care pharmacist-driven intervention: pharmacists pend discharge antimicrobial orders and write progress notes for patients with uncomplicated infections being discharged on antibiotics. Identification of ASP TOC opportunities through an electronic scoring system the electronic health record (EHR) may allow for earlier and more frequent identification of pharmacist intervention. Aim: To evaluate a systematic process using an electronic variable (ASP TOC LRTI variable) in the electronic scoring system to identify patients eligible …