Digital Commons Network^™

The Impact Of Trauma-Informed Training, Self-Efficacy, And Work Task Motivation On Meaningful Work For K-12 Public Education Teachers, Alicia M. Kahrs

Doctoral Dissertations and Projects

Over the past decade, schools have increasingly adopted trauma-informed practices (TIP) due to research confirming the negative impact of adverse childhood experiences (ACEs) and trauma on children and youth. This study explored how trauma-informed training affects teachers’ experiences of meaningful work. The study is based on the theoretical frameworks of Deci and Ryan’s self-determination theory (SDT) and Bandura’s self-efficacy theory, as well as Rosso et al.’s (2010) research on meaningful work. The research used a quasi-experimental, nonequivalent group posttest-only design to measure the impact of trauma-informed training on teachers’ sense of meaningful work. Additionally, this study examined the relationship between …

Public Health Implications Of Armed Conflict In Nigeria, Rachel Dibal Simon Karu

Liberty University Research Week

Introduction: Armed conflict is inimical to the health of those affected by it. Nigeria has a long-standing history of armed conflict amidst a battered system. Armed conflict in Nigeria has led to maiming and death and has negatively affected the quality of life of the citizens. It has also affected the delivery of healthcare services and other social determinants of health. Armed conflict in Nigeria has reduced vaccination rates and maternal healthcare utilization and has led to food insecurity in the affected areas. The impact of armed conflict on population health is of grave concern for this nation with the …

Exploring Soap Thickeners: A Comparative Study Of Sodium Chloride To The Alternate Benefits Of Carrageenan And Xanthan Gum, Amanda Kolandjian

Liberty University Research Week

This research aims to explore the impact of thickening agents when formulated in hand soaps. Sodium chloride is the most used additive for soap to create a thicker consistency. It is however known to possibly dry the skin and cause irritation. The focus of this proposal is on comparing the most used ingredient to thicken soap, sodium chloride, with carrageenan and xanthan gum as potential alternatives to thickening. Both carrageenan and xanthan gum provide moisturizing effects along with their ability to thicken solutions. An investigation into the structural properties of these additives will be conducted to better understand how each …

Medical-Dental Staff Topics, 1991 April, Advocate Health - Midwest

Historical Documents - Combined

St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical-Dental Staff Topics". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Includes a staff calendar and information on continuing education opportunities. Contains a letter regarding a Wisconsin anti-discrimination law for patients who test positive with HIV and the medical center's policies.

Inter-Institutional Analysis Of Skin Of Color Representation In Dermatological Lecture Content At Md And Do Medical Schools, Oluwafunke Oluwatosin Ogunremi, Blake Fredericksen, John Komas, Sana Ismail, Siri Knutsen-Larson Md, Valeriy Kozmenko Md, Afia Albin Do

Aesculapius Journal (Health Sciences & Medicine)

The purpose of this study was to analyze the lecture materials provided in medical schools through a diversity lens. Skin pathologies manifest distinctively on various shades of skin and physicians must be equipped with the proper knowledge to identify and diagnose these conditions accurately and promptly. For most medical students, images in prominent textbooks and lecture slides are their first encounter with disease presentations. Therefore, it is important to analyze the diversity of skin tones in the content that is being delivered. Specifically, the use of images featuring darker skin tones compared to those depicting lighter skin tones. This study …

Medical-Dental Staff Topics, 1990 July, Advocate Health - Midwest

Historical Documents - Combined

St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical-Dental Staff Topics". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Includes a staff calendar and information on continuing education opportunities.

Medical-Dental Staff Topics, 1990 August, Advocate Health - Midwest

Historical Documents - Combined

St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical-Dental Staff Topics". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Includes a staff calendar and information on continuing education opportunities.

Medical-Dental Staff Topics, 1989 March, Advocate Health - Midwest

Historical Documents - Combined

St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical-Dental Staff Topics". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Includes a staff calendar and information on continuing education opportunities.

Medical-Dental Staff Topics, 1989 April, Advocate Health - Midwest

Historical Documents - Combined

St. Luke's Medical Center, Milwaukee, WI: An issue of "Medical-Dental Staff Topics". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Includes a staff calendar and information on continuing education opportunities. Contains an organizational chart for administration and departments at that time.

A General Mortality Analysis In 19th And Early 20th Century Rochester, New York: “Exploring Sex-Based Differences In Childhood And Adolescence Mortality Rates Across Age Groups”, Chizoba Okorie

Proceedings of GREAT Day

This paper represents the initial phase of a research study that explores health and disease in 19th- and early 20th-century Rochester. The research focuses on the prevalence of historic diseases through the transcription and analysis of cemetery records for Mount Hope Cemetery. The purpose of this study is to compare mortality rates in childhood and adolescence across different age groups of males and females. The study investigates the average ages at death, as well as potential factors that may have contributed to mortality rates in these age groups. The study also seeks to identify the variety of factors (social, economic, …

Investigation Of The Prevalence Of Ifitm3 Polymorphisms (Rs12252 And Rs34481144) In Turkish Population: A Pilot Study And Survey Conducted During The Covid-19 Pandemic, Dilek Pirim, Fatih Atilla Bağcı, Hasan Faruk Niş, Emin Halis Akalın

Human Biology Open Access Pre-Prints

Interferon-induced Transmembrane Protein 3 (IFITM3) plays a substantial role in the immune system by repressing viral entry into host cells and restricting virus replication. Recent research suggests that IFITM3/rs34481144 and IFITM3/rs12252 contribute to susceptibility to viral infections across populations dependent on their population frequencies, which needs further clarification. Here, we conducted a population-based study to determine the prevalence of two regulator SNPs in the Turkish population and evaluated genotype and allele frequencies in individuals stratified into groups based on a pilot survey conducted during the COVID-19 pandemic. The Tetra-Primer Arms PCR (TPA-PCR) assays and Sanger sequencing methods were used for …

To Decipher Genomic Evolution Of Dengue Virus And To Probe The Activation Mechanism Of A Her2 Directed Chimeric Antigen Receptor Toward Computer Aided Drug Design (Cadd), Mariya Hryb

Theses and Dissertations

This study encompasses three significant chapters focusing on diverse yet interconnected aspects of pharmaceutical research. Chapter 1 delves into the complexities of drug development, emphasizing the challenges and the pressing need for advanced technologies to streamline the process. Computational methods like Computer-Aided Drug Design (CADD) extend their scope beyond small molecules, aiding in the design of intricate biomolecules vital for biomedical advancements, especially in immunotherapy. Chapter 2 introduces the Near-Neutral Balanced Selectionist Theory (NNBST) validated through analysis of Dengue virus evolution. The unique features observed align with NNBST, surpassing existing theories. This approach offers a deeper understanding of viral evolution …

Production Of Mrna Vaccine For Influenza, Christina Miller

Honors Theses

The objective of this project is to design a process to produce an mRNA influenza vaccine that serves as an alternative to conventional influenza vaccines, replacing current options with innovative mRNA technologies. Given that older populations are most likely to follow up on immunizations consistently, and the increasing average age worldwide, the market for this project appears to be expanding in the next 80 years. Additionally, experts predict more frequent mutations and outbreaks of viral disease from a variety of factors including globalization and global temperature trends. Rapid response to these viral outbreaks will continue to be as, or even …

Self-Assembled Sting-Activating Coordination Nanoparticles For Cancer Immunotherapy And Vaccine Applications, Xiaoqi Sun, Xuehui Huang, Kyung Soo Park, Xingwu Zhou, Andrew A Kennedy, Carla D Pretto, Qi Wu, Ziye Wan, Yao Xu, Wang Gong, Jonathan Z Sexton, Andrew W Tai, Yu Leo Lei, James J Moon

Faculty, Staff and Student Publications

The cGAS-STING pathway plays a crucial role in innate immune activation against cancer and infections, and STING agonists based on cyclic dinucleotides (CDN) have garnered attention for their potential use in cancer immunotherapy and vaccines. However, the limited drug-like properties of CDN necessitate an efficient delivery system to the immune system. To address these challenges, we developed an immunostimulatory delivery system for STING agonists. Here, we have examined aqueous coordination interactions between CDN and metal ions and report that CDN mixed with Zn2+ and Mn2+ formed distinctive crystal structures. Further pharmaceutical engineering led to the development of a functional coordination …

Development Of Novel Analytical Methods For The Investigation Of Mammalian Tissues And Cells, Grace A. Binder

USF Tampa Graduate Theses and Dissertations

This dissertation endeavors to advance the frontiers of analytical chemistry by addressing critical challenges across three distinct chapters. In the first chapter, the focus is on the evaluation of digestion methods for the analysis of trace metals in mammalian tissues and the Standard Reference Material NIST 1577c. The primary goal is to optimize methodologies, laying the groundwork for reliable trace metal analysis and furthering our understanding of their roles in biological systems.

Transitioning into the realm of immunomodulation, the second chapter elucidates immune response, disease and treatment through the optimization and discovery of STING modulators, utilizing the luciferase assay for …

Potential Adverse Cardiovascular Side Effects Following Mrna Covid-19 Vaccination, Abigayle Strohmeier

Liberty University Research Week

In late 2019 and early 2020, we observed the emergence of Severe Acute Respiratory Syndrome 2 (SARS-CoV-2), which quickly spread around the world, becoming a pandemic and global health crisis. This study, via a literature review, presents an epidemiologic examination of the adverse effects of the mRNA Covid-19 vaccine. Research findings are compiled and compared to better understand the cardiovascular effects of the vaccine from a population level perspective. Incidence and prevalence rates are examined by various demographic factors, primarily age and gender. Specifically, the most prevalent adverse cardiovascular effects noted are myocarditis, pericarditis, cardiovascular disease, tachycardia, hypertension, palpitation, and …

An Exploration Of The Effectiveness Of Xanthorrhiza Simplicissima And Its Secondary Alkaloids As Antibiotics Against Staphylococcus Aureus With The Use Of Reserpine, Donald Bothe, Savita Chaurasia

Undergraduate Theses

Xanthorhiza simplicissima is a plant that is steeped in medical history. It has been used for hundreds of years by the Native Americans, and later by the Europeans, of Appalachia for its medicinal properties. One of the most useful medical applications of this plant are its antibiotic properties, as typified by its use as a tea that was consumed to treat mouth sores. These antibiotic properties can be attributed to some of its secondary alkaloids such as berberine, liriodenine, oxyacanthine, and magnoflorine. These compounds have been studied in other systems; however, oxyacanthine and magnoflorine have not been researched in tandem …

Vitamin A Status Modulates Epithelial Mesenchymal Transition In The Lung: The Role Of Furin, M Teresa Cabezuelo, Luis Torres, Elena Ortiz-Zapater, Gerardo López-Rodas, M Pilar Marín, Joaquín Timoneda, Juan R Viña, Rosa Zaragozá, Teresa Barber

Faculty, Staff and Student Publications

Vitamin A deficiency (VAD) induced TGF-β hyperactivation and reduced expression of cell adhesion proteins in the lung, suggesting that the disruption of retinoic acid (RA) signaling leads to epithelial-mesenchymal transition (EMT). To elucidate the role of lung vitamin A status in EMT, several EMT markers and the expression of the proprotein convertase furin, which activates TGF-β, were analyzed in two experimental models. Our in vivo model included control rats, VAD rats, and both control rats and VAD rats, treated with RA. For the in vitro studies, human bronchoalveolar epithelial cells treated with RA were used. Our data show that EMT …

Brief Report: Substance Use Care Continuum In Women With And Without Hiv In The Southern United States, Aditi Ramakrishnan, Ayako W. Fujita, C. Christina Mehta, Tracey E. Wilson, Steve Shoptaw, Adam Carrico, Adaora A. Adimora, Ellen F. Eaton, Deborah L. Jones, Aruna Chandran, Anandi N. Sheth

2020-Current year OA Pubs

BACKGROUND: Substance use (SU) contributes to poor outcomes among persons living with HIV. Women living with HIV (WWH) in the United States are disproportionately affected in the South, and examining SU patterns, treatment, and HIV outcomes in this population is integral to addressing HIV and SU disparities.

METHODS: WWH and comparable women without HIV (WWOH) who enrolled 2013-2015 in the Women's Interagency HIV Study Southern sites (Atlanta, Birmingham/Jackson, Chapel Hill, and Miami) and reported SU (self-reported nonmedical use of drugs) in the past year were included. SU and treatment were described annually from enrollment to the end of follow-up. HIV …

Why Not Mold? A Meta-Narrative Review Of Maldi-Tof Ms, Esmeralda Rojo Santibanez, Destanie Corrine Lechuga, Karen Brigette Vallejos, Emily Cheng Eng

Research Methods Poster Session 2024

Hospitals have recorded immunocompromised patients to be highly susceptible to hospital acquired infections caused by yeasts and molds. Successfully identifying such pathogens is important for the rapid diagnosis and treatment of these infections, marking the significance of this study. Since 2010, Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) has made mold identification more efficient but its usage in clinical laboratories is widely restricted. With an aim to understand this paradox, this meta-narrative review investigates the limited use of MALDI-TOF MS in mold identification, including factors affecting the accuracy and preparation of specimens. PubMed Central Database was …

Agent-Based Modeling For The Neophyte: An Application Of Netlogo, Olcay Akman, Siddharth Bhumpelli, Christopher Hay-Jahans

Faculty, Staff, and Students

Agent-based modeling has found applications in a wide range of fields including economics, sociology, ecology, epidemiology, transportation planning, and more. Its versatility allows researchers to investigate various “what-if” scenarios, test the effects of different policies or interventions, and gain insights into the underlying mechanisms driving complex systems. This article is intended for the curious student or researcher who is unfamiliar with agentbased modeling and is looking for a quick but reasonably informative exposure to the field.

Compartmental Modeling For The Neophyte: An Application Of Berkeley-Madonna, Olcay Akman, Siddharth Bhumpelli, Cody Cline, Christopher Hay-Jahans

Faculty, Staff, and Students

Compartmental modeling serves as a necessary framework in many fields, especially biomathematics and ecology. This article introduces readers to a user-friendly approach to constructing compartmental models and solving the resulting systems of differential equations to simulate real-world applications. The platform used is Berkeley Madonna, a software package that has an intuitive graphical interface which empowers users—even those with limited mathematical and programming backgrounds—to focus on modeling concepts rather than mathematical or programming intricacies. This makes Berkeley Madonna an ideal platform for students, educators, and researchers.

Substance Users’ Perspectives On Harm Reduction Strategies In Housing First Programs, Tammy Montague

Walden Dissertations and Doctoral Studies

The social problem of housing instability for individuals with substance use issues is well known. Researchers have found that 50% of homeless individuals have a substance use disorder with a reduction in life expectancy compared to the general population. With 1% of the U.S. population experiencing homelessness, Housing First with its core component of harm reduction has been embraced by U.S. policymakers as a strategic solution towards ending homelessness through low-barrier permanent supportive housing. This generic qualitative study explored the perspectives of individuals with substance use experience about harm reduction strategies accessed that helped them to overcome system related barriers. …

Increasing The Level Of Awareness On Sexually Transmitted Infections (Stis) Of Grade 12 Students Through #I Am Un(Safe) Campaign, Samboy D. Niala

Annual Research Congress for High School and Elementary Teachers, Researchers, and Scholars (ARCHERS)

Sexually Transmitted Infection (STI) stands out as a crucial health concern, particularly for young adults. Achieving healthy lives and promoting well-being across all age groups aligns with the Sustainable Development Goals, which also emphasize a commitment to ending the AIDS epidemic. The researcher conducted this study at Tagkawayan National High School to elevate Grade 12 students' awareness of Sexually Transmitted Infections (STIs) through the #Iam(un)safe Campaign. Utilizing a quasi-experimental design, the researcher employed pre-tests and post-tests to gauge students' awareness levels. Seventy-five students were purposively selected as respondents, and the pre-test revealed a low awareness level, especially regarding the causes …

Strategic Approaches To Mitigate The Impact Of Ebola Virus Disease In West African Nations

Defensive Publications Series

Ebola Virus Disease (EVD) poses a significant threat to global health, with mortality rates ranging from 50% to 90% during outbreaks. Identified initially in 1976 near the Ebola River in what is now the Democratic Republic of Congo, EVD has periodically led to severe outbreaks. The recent epidemic in West Africa, notably affecting Guinea, Sierra Leone, and Liberia, underscores the urgent need for robust health infrastructure and international collaboration to address such pandemics. This study delves into the outbreak's dynamics and countermeasures in these countries, aiming to shed light on enhancing global health responses to EVD and similar health emergencies. …

The National Basketball Association Communications Strategy For The 2019-20 Season Restart, Trevor Dale Jones

Theses and Dissertations

This paper analyzes the NBA's communications efforts from June 4 to July 30, 2020 as it prepared for an unprecedented season restart in the early days of a global pandemic. While scholars have examined the media's framing of the NBA in this period, there is a gap in the literature when looking at the official NBA communications strategy of the organization itself. As the first study to use risk communication theory in a sports scenario while also employing corporate social advocacy as the second theoretical basis of analysis, this qualitative study is a thematic and textual analysis of 14 NBA …

Shots Fired, Shots Refused: Scientific, Ethical & Legal Challenges Surrounding The U.S. Military's Covid-19 Vaccine Mandate, Shawn Mckelvy, L. William Uhl, Armand Balboni

St. Mary's Law Journal

The COVID-19 pandemic provided uncertain and challenging circumstances under which to lead a nation and the military that protects it. Those in charge and in command faced unique challenges—scientific, ethical, and legal—at our various levels of government to both keep people safe while keeping government and society functioning. While there were many successes to celebrate, there are also many criticisms for how this “whole-of-government approach” may have degraded some of our most cherished liberties along the way. The authors focus on the U.S. military’s vaccine mandate and propose military leaders may have failed to fully consider the evolving science, weigh …

Heterogeneity And Plasticity Of The Naïve Cd4+ T Cell Compartment, Alia Sajani

Dartmouth College Ph.D Dissertations

Recent studies have illuminated unexpected heterogeneity in the naïve T cell compartment. Using single cell RNA sequencing of mouse naïve CD4⁺ T cells, we identified 5 unique transcriptional subsets within the naïve CD4⁺ T cell compartment. These include a quiescence cluster (T^Q) marked by Klf2, Klf6, Jun and Btg2, a memory-like cluster (T^MEM) marked by Ccr7, Il7r and Tcf7, a TCR reactive cluster (T^TCR) marked by Cd5, Cd6 and Nr4a1, an IFN responsive cluster (T^IFN) marked by Stat1, Irf7 and Ifit1 and …

Structural Basis Of Dna Crossover Capture By Escherichia Coli Dna Gyrase, Marlène Vayssières, Nils Marechal, Long Yun, Brian Lopez Duran, Naveen Kumar Murugasamy, Jonathan M Fogg, Lynn Zechiedrich, Marc Nadal, Valérie Lamour

Faculty, Staff and Students Publications

DNA supercoiling must be precisely regulated by topoisomerases to prevent DNA entanglement. The interaction of type IIA DNA topoisomerases with two DNA molecules, enabling the transport of one duplex through the transient double-stranded break of the other, remains elusive owing to structures derived solely from single linear duplex DNAs lacking topological constraints. Using cryo–electron microscopy, we solved the structure of Escherichia coli DNA gyrase bound to a negatively supercoiled minicircle DNA. We show how DNA gyrase captures a DNA crossover, revealing both conserved molecular grooves that accommodate the DNA helices. Together with molecular tweezer experiments, the structure shows that the …

Cmv Retinitis: An Expert’S Perspective, Caitlyn Kwun, Ba

inSIGHT

Uveitis is a rare inflammatory disease with a prevalence of around 38 per 100,000 people and is the overall 5th leading cause of blindness in the developed world.^1,2 Uveitis is most commonly found in patients younger than 40 years of age, but it can occur in any age group with an etiology that varies within each age demographic.^1,3 While the etiology of certain forms of uveitis are not fully understood, there are some that are autoimmune in nature and others that are associated with systemic diseases such as sarcoidosis.⁴ Uveitis may be inflammatory or infectious. It may …