Digital Commons Network^™

Ai Assistance In The Drug Development Process: Reaching For A Regulatory Framework, Haley Giaramita

Seton Hall Law Review

No abstract provided.

Student Research Symposium Schedule 2024, Texas A&M University-San Antonio

Student Research Symposium 2024 (Archived)

No abstract provided.

Centralized Interactive Phenomics Resource: An Integrated Online Phenomics Knowledgebase For Health Data Users, Jacqueline Honerlaw, Yuk-Lam Ho, Francesca Fontin, Michael Murray, Ashley Galloway, David Heise, Keith Connatser, Laura Davies, Jeffrey Gosian, Monika Maripuri, John Russo, Rahul Sangar, Vidisha Tanukonda, Edward Zielinski, Maureen Dubreuil, Andrew J Zimolzak, Vidul A Panickan, Su-Chun Cheng, Stacey B Whitbourne, David R Gagnon, Tianxi Cai, Katherine P Liao, Rachel B Ramoni, J Michael Gaziano, Sumitra Muralidhar, Kelly Cho

Faculty, Staff and Students Publications

Objective: Development of clinical phenotypes from electronic health records (EHRs) can be resource intensive. Several phenotype libraries have been created to facilitate reuse of definitions. However, these platforms vary in target audience and utility. We describe the development of the Centralized Interactive Phenomics Resource (CIPHER) knowledgebase, a comprehensive public-facing phenotype library, which aims to facilitate clinical and health services research.

Materials and methods: The platform was designed to collect and catalog EHR-based computable phenotype algorithms from any healthcare system, scale metadata management, facilitate phenotype discovery, and allow for integration of tools and user workflows. Phenomics experts were engaged in the …

Analysis Of Rabies Neutralizing Antibody Titers In The Feline Population Of Winona County, Olivia M. Hendrickson, Jensen K. Christensen

Research & Creative Achievement Day

Canine rabies vaccination, vital for both animal and human health, is well studied and understood. In contrast, our understanding of feline rabies vaccinations, particularly with those that have a compromised immune status, is much less comprehensive. The purpose of this project is to enhance our current knowledge of feline vaccination states through a surveillance study on the feline rabies antibody titer in Winona County's cat population. Specifically, we seek to explore the relationship between an individual feline's immune status and their active anti-rabies antibody titer. To achieve this, we conducted a bicinchoninic acid (BCA) protein assay to determine the total …

Detection Of Lyme's Disease Caused By Borrelia Burgdorferi In Ixodes Scapularis Using A Pcr Multiplex And Real-Time Pcr, Emily T. Dittman, Bethany G. Basile

Research & Creative Achievement Day

Ixodes scapularis (deer ticks) are a vector for the bacterium Borrelia burgdorferi that is known to cause Lyme's Disease in animals and humans (Homo sapiens). In the past few years, there has been an increase in the prevalence of Lyme's Disease cases throughout the midwestern United States indicating that many ticks have been infected with B. burgdorferi. Using I. scapularis DNA samples collected from white-tailed deer (Odocoileus virginianus) in the spring of 2006 from Buffalo County, WI and Winona County, MN, both traditional and real-time PCR methods were used to test for the presence of the B. burgdorferi organism in …

Creating A Best Practice Model For Reopening Parish Nurse Sites Post-Pandemic, Mary Lynne Knighten Dnp, Rn, Nea-Bc

International Journal of Faith Community Nursing

Abstract

The COVID-19 pandemic brought many changes to the healthcare delivery system. Parish nurses, faith community nurses, and congregational nurses found their practice frequently adapting to comply with government issued restrictions and the changing needs of the community. QueensCare Health & Faith Partnership (QHFP), a parish nurse program which is part of QueensCare, a non-profit public benefit corporation, and St. Dominic Catholic Church in Los Angeles, California designed a replicable model for safely reopening parish nurse sites. QHFP provides supportive healthcare services and case management services at no charge to underserved and vulnerable populations in cooperation with numerous churches, temples, …

Guest Editorial, Phyllis Ann Solari-Twadell Phd, Rn, Mpa, Faan

International Journal of Faith Community Nursing

None

Medical School Watercooler Newsletter - April 18, 2024, Lindsey Lyle

Watercooler Newsletter

This is the April 18, 2024 edition of the Frederick P. Whiddon College of Medicine’s newsletter - Watercooler.

Contents Include:

• Meet a Med Student: Lee Givens
• Class of 2024 looks forward to spring ceremonies
• Custodio named director of pediatrics residency program
• USA launches Healthcare Leadership Certificate program
• Altun to present on collaborative care in treatment of inflammatory bowel disease
• Activities planned for Earth Day

Predisposing Deleterious Variants In The Cancer-Associated Human Kinases In The Global Populations, Salman Ahmed Khan, Misbah Anwar, Atia Gohar, Moom R. Roosan, Daniel C. Hoessli, Ambrina Khatoon, Muhammad Shakeel

Pharmacy Faculty Articles and Research

Human kinases play essential and diverse roles in the cellular activities of maintaining homeostasis and growth. Genetic mutations in the genes encoding the kinases (or phosphotransferases) have been linked with various types of cancers. In this study, we cataloged mutations in 500 kinases genes in >65,000 individuals of global populations from the Human Genetic Diversity Project (HGDP) and ExAC databases, and assessed their potentially deleterious impact by using the in silico tools SIFT, Polyphen2, and CADD. The analysis highlighted 35 deleterious non-synonymous SNVs in the ExAC and 5 SNVs in the HGDP project. Notably, a higher number of deleterious mutations …

Using Strategic Planning To Improve Volunteer Recruitment And Retention For Nonprofits In The Post-Pandemic Era, Antonio L. Mccormack

Walden Dissertations and Doctoral Studies

COVID-19 has changed U.S. culture and negatively affected society worldwide, especially nonprofit organizations that provide community service. Since the pandemic, nonprofit agencies encountered many hardships, especially with the loss of personnel, primarily volunteers. The present study focused on implementing ways to improve recruitment and retention of volunteers for nonprofit organizations in the post-pandemic era through strategic planning. A qualitative approach was deemed the most feasible to conduct this study. This study utilized a SWOT analysis approach, a method of strategic planning used to collect data. A total of 10 interviews were conducted to explore the strengths, weaknesses, opportunities, and threats …

Durability Of Original Monovalent Mrna Vaccine Effectiveness Against Covid-19 Omicron-Associated Hospitalization In Children And Adolescents - United States, 2021-2023., Laura D. Zambrano, Margaret M. Newhams, Regina M. Simeone, Amanda B. Payne, Michael Wu, Amber O. Orzel-Lockwood, Natasha B. Halasa, Jemima M. Calixte, Pia S. Pannaraj, Kanokporn Mongkolrattanothai, Julie A Boom, Leila C Sahni, Satoshi Kamidani, Kathleen Chiotos, Melissa A Cameron, Aline B Maddux, Katherine Irby, Jennifer E. Schuster, Elizabeth H. Mack, Austin Biggs, Bria M. Coates, Kelly N. Michelson, Katherine E. Bline, Ryan A. Nofziger, Hillary Crandall, Charlotte V. Hobbs, Shira J. Gertz, Sabrina M. Heidemann, Tamara T. Bradford, Tracie C. Walker, Stephanie P. Schwartz, Mary Allen Staat, Samina S. Bhumbra, Janet R. Hume, Michele Kong, Melissa S. Stockwell, Thomas J. Connors, Melissa L. Cullimore, Heidi R. Flori, Emily R. Levy, Natalie Z. Cvijanovich, Matt S. Zinter, Mia Maamari, Cindy Bowens, Danielle M. Zerr, Judith A. Guzman-Cottrill, Ivan Gonzalez, Angela P. Campbell, Adrienne G. Randolph, Overcoming Covid-19 Investigators

Manuscripts, Articles, Book Chapters and Other Papers

Pediatric COVID-19 vaccination is effective in preventing COVID-19-related hospitalization, but duration of protection of the original monovalent vaccine during SARS-CoV-2 Omicron predominance merits evaluation, particularly given low coverage with updated COVID-19 vaccines. During December 19, 2021-October 29, 2023, the Overcoming COVID-19 Network evaluated vaccine effectiveness (VE) of ≥2 original monovalent COVID-19 mRNA vaccine doses against COVID-19-related hospitalization and critical illness among U.S. children and adolescents aged 5-18 years, using a case-control design. Too few children and adolescents received bivalent or updated monovalent vaccines to separately evaluate their effectiveness. Most case-patients (persons with a positive SARS-CoV-2 test result) were unvaccinated, despite …

Recent Advances In Nanomaterial-Based Biosensor For Periodontitis Detection, Mohammad Hosseini Hooshiar, Masoud Amiri Moghaddam, Mohammad Kiarashi, Athraa Y Al-Hijazi, Abbas Fadel Hussein, Hareth A Alrikabi, Sara Salari, Samar Esmaelian, Hassan Mesgari, Saman Yasamineh

Faculty, Staff and Student Publications

Periodontitis, a chronic inflammatory condition caused by bacteria, often causes gradual destruction of the components that support teeth, such as the alveolar bone, cementum, periodontal ligament, and gingiva. This ultimately results in teeth becoming loose and eventually falling out. Timely identification has a crucial role in preventing and controlling its progression. Clinical measures are used to diagnose periodontitis. However, now, there is a hunt for alternative diagnostic and monitoring methods due to the progress of technology. Various biomarkers have been assessed using multiple bodily fluids as sample sources. Furthermore, conventional periodontal categorization factors do not provide significant insights into the …

Latent Tb Treatment Regimens In 2023: Wetmore Tb Clinic In New Orleans, Amy Wolfe, Priyanka Jadhav, Amber May, Shandrica Seymour, Angela Blanchard, Juzar Ali

School of Medicine Faculty Publications

The USPSTF has updated Latent TB Infection (LTBI) screening and treatment recommendations in 2023; describing treatment courses, side effects and benefits associated with each regimen. Overall, rifampin-containing shortened regimens are the preferred modality for LTBI treatment. A recent study in 2023 evaluated adherence and tolerance of the isoniazid(INH) + rifapentine(RPT), or “3HP” regimen and identified patient groups that may be at higher risk for non-completion of this regimen. It emphasized the need for targeted education at the beginning of treatment, to avoid early discontinuation. Our experience in New Orleans demonstrated that the 3HP is well-tolerated, with higher completion rates than …

Antiviral Cellular Therapy For Enhancing T-Cell Reconstitution Before Or After Hematopoietic Stem Cell Transplantation (Aces): A Two-Arm, Open Label Phase Ii Interventional Trial Of Pediatric Patients With Risk Factor Assessment., Michael D. Keller, Patrick J. Hanley, Yueh-Yun Chi, Paibel Aguayo-Hiraldo, Christopher C. Dvorak, Michael R. Verneris, Donald B. Kohn, Sung-Yun Pai, Blachy J. Dávila Saldaña, Benjamin Hanisch, Troy C. Quigg, Roberta H. Adams, Ann Dahlberg, Shanmuganathan Chandrakasan, Hasibul Hasan, Jemily Malvar, Mariah A. Jensen-Wachspress, Christopher A. Lazarski, Gelina Sani, John M. Idso, Haili Lang, Pamela Chansky, Chase D. Mccann, Jay Tanna, Allistair A. Abraham, Jennifer L. Webb, Abeer Shibli, Amy K. Keating, Prakash Satwani, Pawel Muranski, Erin Hall, Michael J. Eckrich, Evan Shereck, Holly Miller, Ewelina Mamcarz, Rajni Agarwal, Satiro N. De Oliveira, Mark T. Vander Lugt, Christen L. Ebens, Victor M. Aquino, Jeffrey J. Bednarski, Julia Chu, Suhag Parikh, Jennifer Whangbo, Michail Lionakis, Elias T. Zambidis, Elizabeth Gourdine, Catherine M. Bollard, Michael A. Pulsipher

Manuscripts, Articles, Book Chapters and Other Papers

Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral infections in prior studies. We performed a phase II multicenter study (NCT03475212) for the treatment of pediatric patients with inborn errors of immunity and/or post allogeneic hematopoietic stem cell transplant with refractory viral infections using partially-HLA matched VSTs targeting cytomegalovirus, Epstein-Barr virus, or adenovirus. Primary endpoints were feasibility, safety, and clinical responses (>1 log reduction in viremia at 28 days). Secondary endpoints were reconstitution of antiviral immunity and persistence of the infused VSTs. Suitable VST …

Family Medicine’S Role In Addressing The Intersections Of Redlining And Climate Change, Daryl O. Traylor, Eboni E. Anderson, Brianna Clark, Alex M. Smith, Cooper K. Allenbrand

Journal of Sustainable Social Impact

Redlining, the practice of discriminating against specific neighborhoods based on race and socioeconomic status, leads to persistent environmental hazards and socioeconomic inequalities that have lasting adverse health effects on their populations. Health disparities are further exacerbated through the concentration of environmental hazards, as well as the escalating impact of climate change, which poses an increased risk of respiratory illness, cardiovascular disease, mental health issues, heat-related illness, infectious diseases, food insecurity, and socioeconomic difficulties in redline neighborhoods.

This paper examines the interplay of redlining, climate change, and health disparities, with an emphasis on the enduring consequences for these marginalized communities. Through …

The Association Of Prenatal Fine Particulate Matter (Pm2.5) Airway Exposure And Pulmonary Function Among Preschool Children: The Mediation Effect Of Dna Methylation At Birth And Metabolites, Nutrients, And Toxins In Cord Blood, Rui Luo

Electronic Theses and Dissertations Archive

Prenatal exposure to particulate matter with an aerodynamic diameter of less than 2.5 µm (PM2.5) has been linked to altered lung function and respiratory diseases. However, the conclusions of previous studies are controversial. To our knowledge, no study examined whether DNA methylation (DNAm), metabolites, nutrients, and toxins (MNTs) at birth mediate the association between prenatal PM2.5 exposure with multiple respiratory outcomes. This dissertation includes three carefully designed studies focusing on prenatal PM2.5 exposure, and its association with respiratory outcomes. Data obtained from three generation of Isle of Wight birth cohort (IOWBC) were utilized. In the first study, I examined the …

Antiviral Cellular Therapy For Enhancing T-Cell Reconstitution Before Or After Hematopoietic Stem Cell Transplantation (Aces): A Two-Arm, Open Label Phase Ii Interventional Trial Of Pediatric Patients With Risk Factor Assessment, Michael D Keller, Jeffrey J Bednarski, Et Al.

2020-Current year OA Pubs

Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral infections in prior studies. We performed a phase II multicenter study (NCT03475212) for the treatment of pediatric patients with inborn errors of immunity and/or post allogeneic hematopoietic stem cell transplant with refractory viral infections using partially-HLA matched VSTs targeting cytomegalovirus, Epstein-Barr virus, or adenovirus. Primary endpoints were feasibility, safety, and clinical responses (>1 log reduction in viremia at 28 days). Secondary endpoints were reconstitution of antiviral immunity and persistence of the infused VSTs. Suitable VST …

Dismantling Barriers To Hepatitis B And Delta Screening, Prevention, And Linkage To Care Among The Pwud Community In Philadelphia, Beatrice Zovich, Catherine Freeland, Holly Moore, Kara Sapp, Anousha Qureshi, Rachel Holbert, Jason Zambrano, Daljinder Bhangoo, Chari Cohen, Richard W. Hass, Amy Jessop

College of Population Health Faculty Papers

The prevalence of hepatitis B and delta viruses (HBV/HDV) among people who use drugs (PWUD) remains largely unknown. In the context of one Philadelphia-based harm reduction organization (HRO), this study aimed to assess HBV/HDV prevalence and facilitate linkage to care. Participants completed a demographic HBV/HDV risk factor survey and were screened for HBV and reflexively for HDV if positive for HBV surface antigen or isolated core antibody. Fisher's exact tests and regression were used to understand relationships between risks and HBV blood markers. Of the 498 participants, 126 (25.3%) did not have hepatitis B immunity, 52.6% had been vaccinated against …

Mechanisms Of Rod Photoreceptor Metabolism And Function In Health And Disease, Tae Jun Lee

Arts & Sciences Graduate Student Theses and Dissertations

Over 250 million people globally live with visual acuity loss or blindness as an estimated 7 million people suffer from visual acuity loss in the United States. People in the United States value vision over memory, hearing, or speech and consider losing vision to be among the top four worst outcome to happen to them. The economic cost of major vision problems is estimated to increase to 373 billion dollars by the year 2050. Among the irreparable causes of vision loss, retinal degeneration stands as a chief contributor to catastrophic eye disease. The retina is a neurosensory tissue located in …

Innovation At A Crossroads: The Supreme Court's Influence On Pharmaceuticals, Trade Policies, And Public Health, Beau Reeves

DePaul Journal of Art, Technology & Intellectual Property Law

No abstract provided.

"'What The Suffering Was Like': Digital Affect In The Act Up Oral History Project, Margaret Sullivan

Remembrance: A Journal of Queer Culture, Information, and Preservation

This article considers The ACT UP Oral History Project as an affective site that renders visible the impact of loss and suffering. Focusing on the archive’s filmic and computer-mediated interviews, and placing both in conversation with memory and queer identity studies, I demonstrate that the Oral History Project, as a discursive space, invites its audience into a felt physical contact with grief, loss, anger, and rage.

Can Dogs Sniff Out Covid-19? A Review Of Canine Scent Detection, Savannah Reed, Smita Joshi

2024 Celebration of Student Scholarship - Poster Presentations

The purpose of this research is to explore if scent-trained canines are an effective way to screen for SARS-CoV-2, specifically, in high traffic areas. This method is being explored due to the canine's remarkable olfactory capabilities to identify individuals infected with SARS-CoV-2. This project provides a comprehensive review of past and ongoing research on canine scent detection for COVID-19 screening. The review synthesizes data from existing studies to assess the viability and reliability of this approach. Two research studies that determined the canines detection susceptibility and accuracy will be examined. The general mechanism used for training the canines included the …

Safety Of Nebulization Of Allogenic Alpha-2 Macroglobulin In Horses, Annabel J. Phipps, Pedro Depedro

2024 Celebration of Student Scholarship - Poster Presentations

Horses suffering from inflammatory airway disease (IAD) and recurrent airway obstruction (RAO), develop lower airway inflammation, resulting in an obstruction of the bronchioles. This obstruction is associated with the following clinical signs: coughing, airway mucus accumulation, increased respiratory effort at rest and exercise intolerance. (Couetil et al., 2016)

IAD affects horses of all ages including young athletic horses. However, RAO mainly affects horses over 7 years of age. The common treatment for RAO includes corticosteroids, bronchodilators, and meticulously adjusting the environment to lower dust particles.

Allogenic Alpha-2 macroglobulin has shown to have anti-inflammatory properties when injected in joint and soft …

The Experience Of Self-Regulation Among Obese Adults During The Covid-19 Pandemic, Nicholas Cunningham

Walden Dissertations and Doctoral Studies

Obesity is considered a disease, an epidemic, and is a risk factor for the development of cardiovascular diseases, certain cancers, poor mental health, and low quality of life. It is also a leading cause of mortality. While it is difficult for obese adults to combat their condition, it was much more challenging during unprecedented times such as the COVID-19 pandemic. Annesi’s self-regulation conceptual framework was used as a basis to ground this study. Research explains the importance of practicing self-regulation to increase physical activity. However, there is little research on the practice of self-regulation to increase physical activity and weight …

Ml241 Antagonizes Erk 1/2 Activation And Inhibits Rotavirus Proliferation, Jinlan Wang, Xiaoqing Hu, Jinyuan Wu, Xiaochen Lin, Rong Chen, Chenxing Lu, Xiaopeng Song, Qingmei Leng, Yan Li, Xiangjing Kuang, Jinmei Li, Lida Yao, Xianqiong Tang, Jun Ye, Guangming Zhang, Maosheng Sun, Yan Zhou, Hongjun Li

Faculty, Staff and Student Publications

Rotavirus (RV) is the main pathogen that causes severe diarrhea in infants and children under 5 years of age. No specific antiviral therapies or licensed anti-rotavirus drugs are available. It is crucial to develop effective and low-toxicity anti-rotavirus small-molecule drugs that act on novel host targets. In this study, a new anti-rotavirus compound was selected by ELISA, and cell activity was detected from 453 small-molecule compounds. The anti-RV effects and underlying mechanisms of the screened compounds were explored. In vitro experimental results showed that the small-molecule compound ML241 has a good effect on inhibiting rotavirus proliferation and has low cytotoxicity …

Nanozyme-Based Sensing Of Dopamine Using Cobalt-Doped Hydroxyapatite Nanocomposite From Waste Bones, Umar Nishan, Nighat Jabeen, Amir Badshah, Nawshad Muhammad, Mohibullah Shah, Irfan Ullah, Saifullah Afridi, Jibran Iqbal, Muhammad Asad, Riaz Ullah, Essam A. Ali, Sarfraz Ahmed, Suvash Chandra Ojha

All Works

Dopamine is one of the most important neurotransmitters and plays a crucial role in various neurological, renal, and cardiovascular systems. However, the abnormal levels of dopamine mainly point to Parkinson’s, Alzheimer’s, cardiovascular diseases, etc. Hydroxyapatite (HAp), owing to its catalytic nature, nanoporous structure, easy synthesis, and biocompatibility, is a promising matrix material. These characteristics make HAp a material of choice for doping metals such as cobalt. The synthesized cobalt-doped hydroxyapatite (Co-HAp) was used as a colorimetric sensing platform for dopamine. The successful synthesis of the platform was confirmed by characterization with FTIR, SEM, EDX, XRD, TGA, etc. The platform demonstrated …

Work-Based Learning Experiences And Students With Intellectual Disabilities: A Qualitative Case Study, Jessy Logan Richard

Doctoral Dissertations and Projects

The purpose of this embedded single-case study was to understand how participation in work-based learning experiences (WBLE) prepares students with intellectual disabilities (ID) for successful post-school competitive employment. The theory guiding this study was Kolb’s experiential learning theory, as it systematically explains the four stages of learning that learners go through during WBLE. This embedded single-case study investigated the experience of 12 work site supervisors supervising students with an ID while participating in WBLE at a restaurant and a hotel and one student who participated in the WBLE. Data were collected using individual interviews, document analysis, and focus groups. The …

Emotional Shared Experiences: A Phenomenological Qualitative Transcendental Study On The Shared Experiences Of Ten Pastors In Rural Central Virginia Due To The Covid 19 Mandate That Closed Their Houses Of Worship, Earnest L. Shannon

Doctoral Dissertations and Projects

The purpose of this qualitative transcendental phenomenological research study was to describe the shared emotional experiences of 10 senior pastors of Christian churches located in rural central Virginia due to the national COVID 19 mandate that forced them to close their houses of worship. Moreover, in the United States of America, a COVID 19 mandate was implemented that closed places of worship, which altered the American pastor’s routine schedule. Therefore, the central research question explicated in this research study was, “What are the personal emotions experienced by 10 senior pastors in rural Virginia during a phenomenon, the national COVID 19 …

The Differences In Covid-19 Infection Rates: An Examination Of Residential Care Communities (Rccs), Han Yang

Doctoral Dissertations and Projects

Infection control practices (ICPs) are crucial for maintaining the health and safety of residents in a residential care community (RCC). This paper examines the differences in COVID-19 infection rates and cases based on the characteristics of RCCs, such as ICPs, personal protective equipment (PPE) shortages, ownership type (for-profit vs. nonprofit), census regions, and RCC size. While ICPs contribute significantly to preventing and controlling the highly contagious virus, a comprehensive program is encouraged to provide a targeted intervention based on RCC’s environmental factors. The importance of the characteristics of the RCCs must be considered in combing with the ICPs to enhance …

The Impact Of Trauma-Informed Training, Self-Efficacy, And Work Task Motivation On Meaningful Work For K-12 Public Education Teachers, Alicia M. Kahrs

Doctoral Dissertations and Projects

Over the past decade, schools have increasingly adopted trauma-informed practices (TIP) due to research confirming the negative impact of adverse childhood experiences (ACEs) and trauma on children and youth. This study explored how trauma-informed training affects teachers’ experiences of meaningful work. The study is based on the theoretical frameworks of Deci and Ryan’s self-determination theory (SDT) and Bandura’s self-efficacy theory, as well as Rosso et al.’s (2010) research on meaningful work. The research used a quasi-experimental, nonequivalent group posttest-only design to measure the impact of trauma-informed training on teachers’ sense of meaningful work. Additionally, this study examined the relationship between …