Digital Commons Network^™

Concurrent Varicella-Zoster Virus Reactivation And Recurrent Herpes Simplex Virus Infection In The C2 Dermatome With Varicella-Zoster Virus Encephalitis: A Case Report And Review Of The Literature., Morgan A Hatlovic, Madison Anzelc, Matthew Franklin

Ambulatory and Primary Care Articles

Herpes simplex virus (HSV) and varicella-zoster virus (VZV) are common viruses that are present in the general population. However, it is uncommon for both viruses to coincide at the same time and location. These viruses infect the nervous system to establish latency and have been associated with neurological disorders. We discuss a case of co-occurring VZV reactivation and recurrent HSV infection with subsequent VZV encephalitis following an insult to the neurologic system.

Population Pharmacokinetic Modelling And Simulation Of Tranexamic Acid In Adult Trauma Patients, Gideon Stitt, Philip C Spinella, Grant V Bochicchio, Ian Roberts, Kevin J Downes, Athena F Zuppa

2020-Current year OA Pubs

AIMS: The aim of this study is to describe the disposition of tranexamic acid (TXA) in adult trauma patients and derive a dosing regimen that optimizes exposure based on a predefined exposure target.

METHODS: We performed a population pharmacokinetic (popPK) analysis of participants enrolled in the Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury (TAMPITI) trial (≥18 years with traumatic injury, given ≥1 blood product and/or requiring immediate transfer to the operating room) who were randomized to a single dose of either 2 or 4 g of TXA ≤2 h from time of injury. PopPK analysis was conducted using nonlinear …

Ai-Driven Deep Learning Techniques In Protein Structure Prediction, Lingtao Chen, Qiaomu Li, Kazi Fahim Ahmad Nasif, Ying Xie, Bobin Deng, Shuteng Niu, Seyedamin Pouriyeh, Zhiyu Dai, Jiawei Chen, Chloe Yixin Xie

2020-Current year OA Pubs

Protein structure prediction is important for understanding their function and behavior. This review study presents a comprehensive review of the computational models used in predicting protein structure. It covers the progression from established protein modeling to state-of-the-art artificial intelligence (AI) frameworks. The paper will start with a brief introduction to protein structures, protein modeling, and AI. The section on established protein modeling will discuss homology modeling, ab initio modeling, and threading. The next section is deep learning-based models. It introduces some state-of-the-art AI models, such as AlphaFold (AlphaFold, AlphaFold2, AlphaFold3), RoseTTAFold, ProteinBERT, etc. This section also discusses how AI techniques …

Bat Humoral Immunity And Its Role In Viral Pathogenesis, Transmission, And Zoonosis, Anne A. Roffler, Daniel P. Maurer, Tamika J. Lunn, Tarja Sironen, Kristian M. Forbes, Aaron G. Schmidt

Biological Sciences Faculty Publications and Presentations

Bats harbor viruses that can cause severe disease and death in humans including filoviruses (e.g., Ebola virus), henipaviruses (e.g., Hendra virus), and coronaviruses (e.g., SARS-CoV). Bats often tolerate these viruses without noticeable adverse immunological effects or succumbing to disease. Previous studies have largely focused on the role of the bat’s innate immune response to control viral pathogenesis, but little is known about bat adaptive immunity. A key component of adaptive immunity is the humoral response, comprised of antibodies that can specifically recognize viral antigens with high affinity. The antibody genes within the 1,400 known bat species are highly diverse, and …

Opportunities To Improve Antibiotic Prescribing For Adults With Acute Sinusitis, United States, 2016–2020, Axel A Vazquez Deida, Destani J Bizune, Christine Kim, John M Sahrmann, Guillermo V Sanchez, Adam L Hersh, Anne M Butler, Lauri A Hicks, Sarah Kabbani

2020-Current year OA Pubs

BACKGROUND: Better understanding differences associated with antibiotic prescribing for acute sinusitis can help inform antibiotic stewardship strategies. We characterized antibiotic prescribing patterns for acute sinusitis among commercially insured adults and explored differences by patient- and prescriber-level factors.

METHODS: Outpatient encounters among adults aged 18 to 64 years diagnosed with sinusitis between 2016 and 2020 were identified by national administrative claims data. We classified antibiotic agents-first-line (amoxicillin-clavulanate or amoxicillin) and second-line (doxycycline, levofloxacin, or moxifloxacin)-and ≤7-day durations as guideline concordant based on clinical practice guidelines. Modified Poisson regression was used to examine the association between patient- and prescriber-level factors and guideline-concordant …

Eliciting Clinician Perspectives On Asymptomatic Bacteriuria To Identify Targets For Antimicrobial Stewardship Education And Decision Support, Michael J Durkin, Viktoria Schmitz, Kevin Hsueh, Katheryn Ney, Mary C Politi

2020-Current year OA Pubs

BACKGROUND: The aim of this study was to elicit clinicians' perspectives to help reduce antibiotic prescribing for asymptomatic bacteriuria and improve a patient-centered educational brochure for older adults with urinary tract infections or asymptomatic bacteriuria.

METHODS: Between October 2023 and April 2024, we conducted semi-structured qualitative interviews of clinicians who treat patients aged ≥65 years for urinary tract infections or bacteria in the urine, at infectious disease clinics, community senior living facilities, memory care clinics, and general practice. We developed an interview guide based on a behavior change framework and thematically analyzed written transcripts of audio-recorded interviews using inductive and …

Overview On The Most Common Microbial Causative Agents Of Diarrhea, Wafaa Ayad Al-Nuaimy, Dhay A. Azeez

Muthanna Medical Journal

In all parts of the world and among all age groups, diarrhea is a significant cause of morbidity and mortality. However, compared to high-income countries, low-income countries have fewer resources and a less resilient infrastructure, which makes them more susceptible to an unfair share of diarrheal morbidity and mortality. The word "diarrhea" originates from the Greek word "dia rEo," referring to "flow through." When the volume of colonic fluid crosses this segment's absorptive capacity due to decreased absorption and/or increased secretion, diarrhea achievements. In infectious diarrheas, the abnormal function is brought about by microorganisms that colonize the intestinal mucosa and …

A Case Of Herpes Zoster In An Immunocompetent 19-Year-Old Female, Martin Nguyen, Jennifer Read, Emma Filary, Aaron Mcguffin

Marshall Journal of Medicine

This case report describes the unusual presentation of herpes zoster in a fully vaccinated teenage patient and highlights management considerations. The patient is a 19-year-old female who presented with pain in her left lower back, side, and upper thigh for approximately 3 days, which was then followed by the eruption of a vesicular rash along the L2 dermatome consistent with herpes zoster. Herpes zoster is predominantly observed only in elderly and immunocompromised individuals, primarily due to the widespread use of the varicella-zoster virus vaccine for children since 1995, when it became part of the routine immunization schedule. However, this case …

Exploring The Dark And Gothic: An Analysis Of Edgar Allan Poe And Nathaniel Hawthorne’S Gothic Elements In American Literature, Alejandra Serna

Theses and Dissertations

This paper examines the significant contributions of Edgar Allan Poe and Nathaniel Hawthorne to the development of American Gothic literature. Poe’s stories “The Tell-Tale Heart” and “The Black Cat” are renowned for their psychological elements and exploration of the human psyche, while Hawthorne’s “The Birthmark” questions the nature of evil as a universal human experience. By examining the ways in which these authors engage with themes of mental disorders, symbolism, and science versus nature, this thesis explores how such work by Poe and Hawthorne play in shaping the readers' understanding of the darker elements of American Gothic literature and its …

Smoking Habit At Home And Upper Respiratory Infection In Infants Aged 6-12 Months, Musfardi Rustam, Nur Pelita Sembiring, Taswir Effendy

Kesmas

Upper Respiratory Tract Infection (URI) is an acute infection caused by viruses, fungi, and bacteria. Smoking habit at home is a risk factor for URI in infants. This study aimed to determine a relationship between smoking at home and the incidence of URI in infants. This study was conducted the fourth week of February 2010 until the third week of April 2010 in Kampar District, Indonesia. This analytical study used a case-control design and cluster random sampling. The samples comprised 162 cases and 162 controls, infants aged 6-12 months. The cases were 162 infants aged 6-12 months suffering from URI …

Analisis Faktor Risiko Kejadian Kematian Akibat Penyakit Kardiovaskular Jemaah Haji Indonesia Tahun 2023, Muhammad Aulia Rahman, Martya Rahmaniati, Raissa Lingga Angesti

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Ibadah haji adalah ibadah yang dilakukan oleh umat muslim di seluruh dunia pada waktu dan tempat yang sudah ditentukan, yang pada tahun 2023 lalu dilakukan oleh 1.845.045 jiwa dari seluruh dunia. Sebagian besar dari kegiatan ibadah haji merupakan kegiatan fisik, ditambah stresor eksternal seperti cuaca, udara yang panas dan teriknya matahari, membuat faktor kesehatan menjadi bagian penting dalam menunjang kelancaran seluruh proses ibadah haji, adapun kriteria sehat tersebut ditentukan berdasarkan istithaah kesehatan jemaah haji. Kematian jemaah haji di tahun 2023 mengalami peningkatan yang cukup signifikan dari tahun-tahun sebelumnya, angkanya mencapai 798 jiwa, dan 42%nya merupakan kematian akibat penyakit kardiovaskular. Oleh …

Economic Loss Of Leptospirosis: Is It Still Appropriate To Be Tropical Neglected Zoonosis Disease?, Wahyu Pudji Nugraheni, Sinta Dewi Lestyoningrum, Ristiyanto Ristiyanto, Wahyu Gito Putro, Indah Pawitaningtyas, Syarifah Nuraini, Linta Meyla Putri, Debri Rizki Faisal, Adhista Eka Noveyani, Muhammad Agus Mikrajab

Kesmas

Leptospirosis is a tropical endemic disease that can reduce the productivity of sufferers. However, research on economic and productivity losses due to leptospirosis is rare. This study aimed to determine economic and productivity losses due to leptospirosis in the Banyumas District, Indonesia, as an endemic area. This study used a cross-sectional design and quantitative methods conducted in October 2022. Secondary data of medical records and billing information from 73 inpatients receiving treatment at a Public Hospital in the Banyumas District from February 2021 to September 2022 obtained from the hospital’s archives were used. This study examined the actual costs (direct …

Data Mining Analysis With Orange In The Development Of Tuberculosis Among Diabetes Mellitus Patients, Malahayati Rusli Bintang, Adang Bachtiar, Cicilya Candi

Kesmas

Prevention and treatment of diabetes will have a positive influence on tuberculosis (TB) since people may get TB because they have diabetes mellitus (DM). Recording and reporting through the TB Information System are not run optimally because of many factors. The information system must be strengthened to be used by private health facilities. This study used secondary data from the 2013 and 2018 Indonesian Basic Health Research (IBHR). The data was analyzed univariately and analyzed further using Orange Data Mining Tools to test the screening tool model used to predict TB in diabetic individuals. The total sample in this study …

New Approach To Mapping Regional Vulnerability In Controlling Tuberculosis Disease In Indonesia, Maria Holly Herawati, Asep Hermawan, Dasuki Dasuki, Hadi Supratikta, Al Asyary, M Rokhis Khomarudin, Muhammad Priyatna, Raflizar Raflizar, Kristina Kristina, Noer Endah Pracoyo, Dina Bisara, Cahya Tri Purnami, Mentari Nur Farida Suteja, Yusrial Bachtiar, Noor Edi Widya Sukoco, Doni Lasut

Kesmas

Tuberculosis (TB) in Indonesia is still a health problem. The TB prevalence in Indonesia ranks second in the world after India in 2023. Regional factors, inadequate healthcare facilities, and limited resources (financial, human, and infrastructure) are challenges requiring innovation to help the government control TB. TB eradication efforts need to be made with a comprehensive and effective approach. One method used is to look at the vast territory of Indonesia, therefore, mapping the TB disease vulnerability is a highly recommended method. The use of a Geographic Information System is expected to help map the TB vulnerability areas in Indonesia. Given …

Adaptative Survival Of Aspergillus Fumigatus To Echinocandins Arises From Cell Wall Remodeling Beyond Β−1,3-Glucan Synthesis Inhibition, Malitha C. Dickwella Widanage, Isha Gautam, Daipayan Sarkar, Frederic Mentink-Vigier, Josh V. Vermaas, Shi You Ding, Andrew S. Lipton, Thierry Fontaine, Jean Paul Latgé, Ping Wang, Tuo Wang

School of Graduate Studies Faculty Publications

Antifungal echinocandins inhibit the biosynthesis of β−1,3-glucan, a major and essential polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins against the pathogen Aspergillus fumigatus is limited. Here, we use solid-state nuclear magnetic resonance (ssNMR) and other techniques to show that echinocandins induce dynamic changes in the assembly of mobile and rigid polymers within the A. fumigatus cell wall. The reduction of β−1,3-glucan induced by echinocandins is accompanied by a concurrent increase in levels of chitin, chitosan, and highly polymorphic α−1,3-glucans, whose physical association with chitin maintains cell wall integrity and modulates water permeability. The rearrangement of …

Bibliometric Analysis Of Research Trends And Novelties For Pneumonia In Children, Ariyani Lutfitasari, Fitriani Nur Damayanti, Budi Santosa, Lia Mulyanti, Umi Khasanah

Jurnal Keperawatan Indonesia

Pneumonia is the leading cause of death among children globally, with most cases occurring in low- and middle-income nations. Pneumonia in children has been thoroughly researched in numerous countries throughout the world. However, no research performed bibliometric analyses of pneumonia in children. This study aims to use a biometric analysis to determine trends in the number of publications, the number of citations, network visualization, overlay visualization, and density visualization concerning the issue of pneumonia in children. This research method employs a systematic review with stages adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart. The highest …

Why Did They Fail? Investigating The Eight Invalid Dimensions Of Patient Safety Culture: Mixed Method Research, Felicia Setiawan, Ferdi Antonio

Jurnal Keperawatan Indonesia

Resistance to adopting patient safety culture practices or technologies can hinder improvements in patient safety. This study contributes to enhancing the understanding of patient safety culture (PSC) assessment by identifying the specific factors that render some PSC dimensions invalid and offering actionable recommendations for improvement in healthcare settings. Primary data were gathered using a mixed method of explanatory sequential design, with quantitative data collection and analysis followed by qualitative data collection and analysis. The study was conducted in the leading Private Hospital XYZ, one of the private hospital groups internationally accredited with Joint Commission International with a 110-patient bed capacity. …

Adaptation Of The Protein Misfolding Cyclic Amplification (Pmca) Technique For The Screening Of Anti-Prion Compounds, Katherine Do, Rebeca Benavente, Celso S G Catumbela, Uffaf Khan, Carlos Kramm, Claudio Soto, Rodrigo Morales

Faculty, Staff and Student Publications

Prion diseases result from the misfolding of the physiological prion protein (PrPC) to a pathogenic conformation (PrPSc). Compelling evidence indicates that prevention and/or reduction of PrPSc replication are promising therapeutic strategies against prion diseases. However, the existence of different PrPSc conformations (or strains) associated with disease represents a major problem when identifying anti-prion compounds. Efforts to identify strain-specific anti-prion molecules are limited by the lack of biologically relevant high-throughput screening platforms to interrogate compound libraries. Here, we describe adaptations to the protein misfolding cyclic amplification (PMCA) technology (able to faithfully replicate PrPSc strains) that increase its throughput to facilitate the …

How Housing Insecurity And Welfare Systems Retraumatize Women In Southern California, Yesika Menera

McNair Summer Research Program

Studies show that individuals experiencing homelessness and housing insecurity also experience trauma and mental illnesses. Despite this evidence, many resources provided through state welfare services seldom allocate sufficient funds and personnel to help address mental health. This study investigates the relationship between housing insecurity and trauma for adult women who have tried to access assistance throughout Southern California. To do this, I conducted in-depth interviews and DSM-5 questionnaires with twenty-six women during the summer of 2023 and 2024 via Zoom. My findings show that adult women who have experienced homelessness and housing insecurity in Southern California were more susceptible to …

Adverse Childhood Experiences, Perceived Socioeconomic Status And Resilience: Health Consequences In Young Adults, Akruti Patel

ETD Collection

Vulnerability to trauma, depression, and chronic conditions in adulthood increases with exposure to early life adversity (ACEs) during childhood. This study investigated the effect of adverse early childhood experiences has on depressive symptoms (measured using the Center for Epidemiologic Studies Depression Screening scale -CESD), somatic symptoms (measured using Cohen- Hoberman Inventory of Physical symptoms scale- CHIPS), resilience (measured using the Brief Resilience Scale- BRS), and young adult health-related quality-of-life (measured using Health Related Quality of Life scale- HRQOL) among a diverse sample of young adults (average age 27 years old). A diverse sample of 341 participants were recruited for the …

Adaptive Immune Profiling Of Sin Nombre Hantavirus And Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Tonilynn M. Baranowski

Biomedical Sciences ETDs

Hantaviruses are causative agents of potentially fatal respiratory illness and/or organ failure in humans worldwide. In the United States, the predominant hantavirus species, Sin Nombre hantavirus (SNV), causes a severe disease pathology, called hantavirus cardiopulmonary syndrome (HCPS). Infection with SNV and subsequent clinical manifestations of HCPS lends itself to case fatality rates approaching 40%, even under supportive care. This is partially due to the lack of FDA-approved vaccines and antivirals, in addition to a deficit in our knowledge regarding the human immune response to SNV. Further investigation of the adaptive immune response may reveal key targets to mediate disease outcome. …

A Quality Improvement Project: Implementing A Mental Health Screening Program For International Business Travelers., Joyce Ighedosa

Doctor of Nursing Practice Final Project Abstract

A Quality Improvement Project: Implementing a Mental Health Screening Program for International Business Travelers.

PURPOSE The purpose of the Quality Improvement project was to implement a mental health screening program for international business travelers in an oil and gas organization. The Patient Health Questionnaire (PHQ-2) was implemented

BACKGROUND The project was implemented in a global oil and gas organization. The original medical screening for pre-travel preparation was on identification of physiological disorders, proper management of identified disease processes; infectious disease prevention; vaccine review and update; malaria chemoprophylaxis and vector control. Mental Health was not reviewed.

METHODOLOGY The PHQ-2 was …

Empowering Patient Care Technicians To Reduce Non-Ventilated Hospital-Acquired Pneumonia In An Acute Care Hospital In Northern California, Barbra Pacatang

Master's Projects and Capstones

Abstract

Problem: Non-ventilator hospital-acquired pneumonia (nv-HAP) is increasingly becoming a significant concern in healthcare settings. Studies have indicated that nv-HAP accounts for a substantial portion of hospital-acquired pneumonia cases, with a high associated mortality rate. The prevalence of nv-HAP underscores the importance of implementing robust HAP prevention bundles. Prevention, early recognition, and appropriate management of nv-HAP are essential to improve patient outcomes and reduce the burden on healthcare facilities.

Context: A 28-bed capacity Stroke Telemetry Unit incurred six nv-HAP incidents in 2023. Patients needed to be more compliant with the nv-HAP prevention bundles. Patient care technicians (PCTs) are instrumental nurses’ …

Pins, Inhwan Jeon

Theses

Pins aims to portray the societal landscape observed and experienced by me as an international student, highlighting sociological concerns like hatred and hate crimes instead of focusing on surface-level metrics such as the risk and fatality rates of COVID-19. Through this work, I want to remind the audience of the multifaceted nature of society and the emotions evoked by COVID-19, prompting reflection on the role of art during times of crisis. While transforming my original medium of metal objects into an installation art format, I explored concepts such as spacing, installation, cognition, narrative, and multiple senses. I integrated these elements …

Gemykibivirus Detection In Acute Encephalitis Patients From Nepal, Eans Tara Tuladhar, Smita Shrestha, Susan Vernon, Lindsay Droit, Kathie A Mihindukulasuriya, Mamta Tamang, Lata Karki, Annie Elong Ngono, Bimlesh Jha, Bal Krishna Awal, Bimal Sharma Chalise, Runa Jha, Sujan Shresta, David Wang, Krishna Das Manandhar

2020-Current year OA Pubs

UNLABELLED: Acute encephalitis syndrome (AES) causes significant morbidity and mortality worldwide. In Nepal, Japanese encephalitis virus (JEV) accounts for ~5-20% of AES cases, but ~75% of AES cases are of unknown etiology. We identified a gemykibivirus in CSF collected in 2020 from an 8-year-old male patient with AES using metagenomic next-generation sequencing. Gemykibiviruses are single stranded, circular DNA viruses in the family

IMPORTANCE: Viral encephalitis is a devastating disease, but unfortunately, worldwide, the causative virus in many cases is unknown. Therefore, it is important to identify viruses that could be responsible for cases of human encephalitis. Here, using metagenomic sequencing …

Advocate Christ Medical Center Year-In-Review Report, 2001, Advocate Health - Midwest

Historical Documents - Combined

Advocate Christ Hospital and Medical Center, Oak Lawn, IL: Annual report for the year 2001. Includes data, statistics, news, and development plans.

Advocate Christ Medical Center Year-In-Review Report, 2002, Advocate Health - Midwest

Historical Documents - Combined

Advocate Christ Hospital and Medical Center, Oak Lawn, IL: Annual report for the year 2002. Includes data, statistics, news, and development plans.

Caring, 1988 Summer, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a semiannual patient education publication. This issue has feature stories on a patient who received care in the Level 1 Trauma Center, a look at recent changes to the nursing field, and one of the AIDS units.

Caring, 1993 Summer, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a semiannual patient education publication. This issue has feature stories on the Pathology Department and on Same Day Surgery.

Caring, 1997 Fall, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a semiannual patient education publication. This issue introduces a new redesign of the magazine and features articles on asthma in children, and on a new Emergency Room Crisis Intervention Program.