Digital Commons Network^™

Guidelines For The Prevention, Diagnosis, And Management Of Urinary Tract Infections In Pediatrics And Adults: A Wikiguidelines Group Consensus Statement, Zachary Nelson, Abdullah Tarik Aslan, Nathan P. Beahm, Michelle Blyth, Matthew Cappiello, Danielle Casaus, Fernando Dominguez, Susan Egbert, Alexandra Hanretty, Tina Khadem, Katie Olney, Ahmed Abdul-Azim, Gloria Aggrey, Daniel T. Anderson, Mariana Barosa, Michael Bosco, Elias B. Chahine, Souradeep Chowdhury, Alyssa Christensen, Daniela De Lima Corvino, Margaret Fitzpatrick, Molly Fleece, Brent Footer, Emily Fox, Bassam Ghanem, Fergus Hamilton, Justin Hayes, Boris Jegorovic, Philipp Jent, Et Al

School of Medicine Faculty Publications

IMPORTANCE: Traditional approaches to practice guidelines frequently result in dissociation between strength of recommendation and quality of evidence. OBJECTIVE: To create a clinical guideline for the diagnosis and management of urinary tract infections that addresses the gap between the evidence and recommendation strength. EVIDENCE REVIEW: This consensus statement and systematic review applied an approach previously established by the WikiGuidelines Group to construct collaborative clinical guidelines. In May 2023, new and existing members were solicited for questions on urinary tract infection prevention, diagnosis, and management. For each topic, literature searches were conducted up until early 2024 in any language. Evidence was …

Nepali Oral Microbiomes Reflect A Gradient Of Lifestyles From Traditional To Industrialized, Erica P Ryu, Yoshina Gautam, Diana M Proctor, Dinesh Bhandari, Sarmila Tandukar, Meera Gupta, Guru Prasad Gautam, David A Relman, Ahmed A Shibl, Jeevan Bahadur Sherchand, Aashish R Jha, Emily R Davenport

Faculty, Staff and Student Publications

Background: Lifestyle plays an important role in shaping the gut microbiome. However, its contributions to the oral microbiome remain less clear, due to the confounding effects of geography and methodology in investigations of populations studied to date. Furthermore, while the oral microbiome seems to differ between foraging and industrialized populations, we lack insight into whether transitions to and away from agrarian lifestyles shape the oral microbiota. Given the growing interest in so-called "vanishing microbiomes" potentially being a risk factor for increased disease prevalence in industrialized populations, it is important that we distinguish lifestyle from geography in the study of microbiomes …

Intrapartum And 30-Day Postpartum Complications In Patients With Antenatal Covid-19 Infection: A Retrospective Cohort Study, Sriya Donthi, Jacqueline Kloos, Kelly S. Gibson, David C. Kaelber

Student Scholarship

Objective: The study was aimed at comparing intrapartum and postpartum outcomes between pregnant patients with and without antenatal COVID-19 infection using aggregated, deidentified electronic health record (EHR) data. Design and Setting: This retrospective cohort study included data from over 80 health care organizations within the TriNetX Analytics Research Network. Population: Individuals admitted for delivery from Jan 2020 to May 2023 were studied. Methods: We studied individuals with ICD-10 codes for delivery, COVID-19 diagnosis, and primary outcomes. We compared the incidence of adverse intrapartum and 30-day postpartum outcomes in those with and without antenatal COVID-19. Main Outcome Measures: The main outcomes …

Post-Artesunate Delayed Hemolysis In Pediatric Malaria Patients In The United States, Sesh A Sundararaman, Karen L Hanze Villavicencio, Brianne Roper, Ziyi Wang, Amy K F Davis, Jonathan A Mayhew, Michelle L Wang, Nina L Tang, Vijaya L Soma, Gail F Shust, Margaret E Feeney, Indi Trehan, Jill E Weatherhead, Chandy C John, Jeffrey S Gerber, Audrey R Odom John

Faculty, Staff and Students Publications

Post-artesunate delayed hemolysis (PADH) occurred in 6 of 24 children treated with artesunate for severe malaria in the United States; however, severe hemolysis requiring hospitalization or transfusion was rare. In children in the United States treated with artesunate, counseling, and symptom monitoring may be preferred to weekly laboratory surveillance for PADH.

The Utilization Of Echocardiography In Children With Staphylococcus Aureus Bacteremia, Richard Bui, Lauren M Sommer, Meghan Walther, Kristina G Hulten, Jesus G Vallejo, Sheldon L Kaplan, J Chase Mcneil

Faculty, Staff and Students Publications

The need for echocardiography in pediatric Staphylococcus aureus bacteremia (SAB) remains uncertain. We reviewed 331 pediatric SAB cases. Nine subjects, all with comorbidities, met the echocardiogram criteria for infective endocarditis (IE). IE was associated with congenital heart disease and prolonged bacteremia, suggesting that echocardiography is unnecessary in most children with SAB.

Quality Of Publicly Available Information About Urinary Tract Infections, Viktoria Schmitz, Zoe Troubh, Michael Durkin, Kevin Hsueh, Katheryn Ney, Brian D Carpenter, Shinbee Waldron, Mary C Politi, Cdc Prevention Epicenters Program

2020-Current year OA Pubs

No abstract provided.

Performance Of Risk Models For Antimicrobial Resistance In Adult Patients With Sepsis, M Cristina Vazquez Guillamet, Hanyang Liu, Andrew Atkinson, Victoria J Fraser, Chenyang Lu, Marin H Kollef

2020-Current year OA Pubs

IMPORTANCE: The results of prediction models that stratify patients with sepsis and risk of resistant gram-negative bacilli (GNB) infections inform treatment guidelines. However, these models do not extrapolate well across hospitals.

OBJECTIVE: To assess whether patient case mix and local prevalence rates of resistance contributed to the variable performance of a general risk stratification GNB sepsis model for community-onset and hospital-onset sepsis across hospitals.

DESIGN, SETTING, AND PARTICIPANTS: This was a retrospective cohort study conducted from January 2016 and October 2021. Adult patients with sepsis at 10 acute-care hospitals in rural and urban areas across Missouri and Illinois were included. …

Diagnosis And Treatment Of Giardia Lamblia Article Review, Wahda A. M. Khrofa, Ramzia H. A. Almizwary, Alyaa A. N. Alsaffo

BioMed Visions Journal

Giardia lamblia is a microscopic parasite belonging to the genus Giardia, renowned for its complex antigenic mechanisms. This parasite predominantly inhabits the small intestine, leading to a range of symptoms, including diarrhea, abdominal pain, and discomfort, affecting both humans and various animals such as dogs, cats, cattle, and sheep. The transmission of Giardia lamblia occurs through contaminated food, surface water, and fecal matter. The parasite spreads primarily through the fecal-oral route when hands contaminated with infected feces is exposed to the mouth, or when the infected cysts are ingested directly or indirectly.

Giardia lamblia goes through two primary life stages …

The Effect Of National School Health Strategy Components On The Quality Of Health Services: An Analytical Research In Baghdad Governorate, Sama Mohammed Kadhim Mohammed Ali, Nada Ismaeel Jabbouri Alqammach

Journal of Economics and Administrative Sciences

Purpose: The research objective is to diagnose the extent to which the National School Health Strategy contributes to the quality of health services. Theoretical framework: The quality of health services can provide schools with benefits through building a healthy school community in line with the sustainable development goals, especially regarding quality education, good health, and well-being and through school health, we may be improving the health and well-being of elementary and secondary students, and the necessity of providing healthy foods reduction of fat content in school meals, and awareness to prevent the use of tobacco products and drugs. Design/methodology/approach: The …

Using The Conditional Maximum Likelihood Function With The Genetic Algorithm To Estimate Starima Models (Pλ,D,Qm), Ali Tareq Abdulmajeed, Firas A. Mohammed Almohana

Journal of Economics and Administrative Sciences

Strategic planning for a specific phenomenon depends mainly on accurate prediction by developing a model to represent that phenomenon. Therefore, this research dealt with spatiotemporal series models such as the STARIMA model (pλ, d, qm) model when there is a spatial correlation for neighbouring sites and a spatial correlation for the same geographical location. The methods for estimating the parameters are the Conditional Maximum Likelihood method and the method of estimating the parameters using the genetic algorithm (MLEGA). These models were compared using the statistical comparison metrics (RMSE). The data represents the daily infections with the COVID-19 epidemic for (10) …

Neuropsychiatric Manifestations Of Syphilis, Nadim Ojaimi, Aida Metri, Christopher James Haas

Journal of Community Hospital Internal Medicine Perspectives

Neurosyphilis is a condition characterized by insidious onset of encephalopathy and delirium. The infrequency with which it is encountered makes neurosyphilis a formidable diagnostic challenge. We present a rare case of a 71-year-old male with ischemic cardiomyopathy, chronic obstructive pulmonary disease (COPD), undifferentiated arthritis and alcohol use disorder who was brought to the emergency department after he was found altered, confused, and paranoid. His hospital stay was eventful for multiple episodes of agitation that were difficult to control despite benzodiazepines and high doses of antipsychotics. After an extensive workup, he was found to have neurosyphilis and his delirium resolved following …

An Atypical Case Of Herpes Simplex 1 Meningitis, Nadim Ojaimi, Sofia Zhang, Marcos Wolff, Christopher James Haas

Journal of Community Hospital Internal Medicine Perspectives

Herpes simplex virus (HSV) is well known to cause Central Nervous System (CNS) infections, ranging from more common HSV-2 viral meningitis to the more rare and severe HSV-1 encephalitis. Here we present an atypical case of aseptic meningitis due to HSV-1. Intriguingly, despite the potential severity of HSV-1 infections, the patient had an uncomplicated course with only mild symptoms that resolved with conservative management alone. This case report aims to provide a frame of reference for the non-specific presentation of a patient with uncommon HSV-1 meningitis.

Type B Aortic Dissection Secondary To Non-Typhoidal Salmonella Aortitis: A Case Report And Literature Review, Laxman Wagle, Dhiraj Raj Regmi, Alexander Reyes, Rashmita Regmi, Sishir Poudel

Journal of Community Hospital Internal Medicine Perspectives

Infectious aortitis is an uncommon but potentially fatal condition that can lead to aortic dissection or rupture. We describe a case of a 69-year-old woman who developed a Stanford type B aortic dissection, presumptively caused by Salmonella, which was successfully managed with thoracic endovascular aneurysm repair (TEVAR) and long-term antibiotics. A literature review of 17 reported cases from 2000 to 2024 of aortic dissection secondary to infectious aortitis was conducted. The most frequently implicated causative organisms were Salmonella and Staphylococcus species. Presenting symptoms were non-specific, such as fever, chest or abdominal pain, and constitutional symptoms. Predisposing factors included hypertension, malignancy, …

Monkeypox Vaccine Hesitancy Among Healthcare Workers In Pakistan, Zahira Ali, Asmara Malik, Jahanzeb Malik, Tooba Fida, Uzma Ishaq, Amna Ashraf, Saqlain Ahmed, Ali Karim, Allah Warayo, Waheed Akhtar

Journal of Community Hospital Internal Medicine Perspectives

Objective This study aimed to investigate healthcare workers (HCWs) acceptance of the HMPXV vaccine in Pakistan and identify influencing factors.

Methods A cross-sectional survey of 4,257 HCWs assessed vaccine acceptance across demographics, ethnicity, marital status, specialty, medical conditions, and education. Logistic regression identified predictors of acceptance.

Results The overall HMPXV vaccine acceptance among HCWs was 73.1%. The gender distribution shows that a majority of participants are female (56.60%) while males constitute 43.40% of the sample. Interestingly, vaccine acceptance is higher among females (68.43%) compared to males (31.57%). Ethnicity in the sample reveals that Punjabi participants are the most common at …

Outcomes Of Low Barrier Hepatitis C Treatment In High Risk Populations From Primary Care, Scarlett Austin, Kristi Seemiller, Brittany Nolton, Emily Hobart, Bruce Ling, Jonathan Ghobrial, Thomas Robertson

Journal of Community Hospital Internal Medicine Perspectives

Hepatitis C (HCV) can be treated in the primary care setting; however, most patients are referred to subspecialists. Marginalized populations may be refused treatment due to stigma or substance use. We aimed to treat HCV in these high-risk patients, and prevent a delay in time from diagnosis to the time of treatment and sustained virologic response (SVR), by utilizing a multidisciplinary treatment team in a primary care clinic. Outcomes assessed included achieving SVR at 3 months, time from diagnosis to treatment initiation, and liver fibrosis stage compared between cohorts with previous subspecialty referral and those treated initially from primary care. …

Behavioral Coping With Chronic Defeat Stress In Mice: A Systematic Review Of Current Protocols, Alina Díez-Solinska, Zurine De Miguel, Garikoitz Azkona, Oscar Vegas

Psychology Faculty Publications and Presentations

Social stress is the most significant source of chronic stress in humans and is commonly associated with health impairment. Individual differences in the behavioral coping responses to stress have been proposed to mediate the negative effects of stress on physical, behavioral and mental health. Animal models, particularly mice, offer valuable insights into the physiological and neurobiological correlates of behavioral coping strategies in response to chronic social stress. Here we aim to identify differences and similarities among stress protocols in mice, with particular attention to how neuroendocrine and/or behavioral responses vary according to different coping strategies, while highlighting the need for …

Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Diabetes On Arterial Compliance, Jadon Bradford

Master's Theses

The prevalence of cardiovascular disease is on a continuous exponential growth across the globe. Thus, research into the underlying factors, effective methods of diagnoses, and preventive measures is necessary. Endothelial dysfunction is an early detector of cardiovascular diseases and can be used to inform people of preventative measures and early treatments before any extreme medical conditions occur. Something that is also on the rise and closely linked with cardiovascular disease is diabetes. There have been many past research studies that show the impact of diabetes on cardiovascular disease and more specifically endothelial dysfunction. A calibrated cuff plethysmography device is a …

Improving Sep-1 Compliance Among Clinicians And Registered Nurses In The Emergency Department, Luke Roesler

Doctor of Nursing Practice Papers

Background: Sepsis is attributable to more than one in three in-hospital deaths in the United States and 20% of deaths globally each year. In 2015, the Centers for Medicare and Medicaid Services (CMS) adopted an early goal-directed 3 and 6-hour bundle intervention measure titled “SEP-1” based on recommendations from the International Surviving Sepsis Campaign (SSC) consensus panel to improve patient outcomes in cases of severe sepsis and septic shock. Sepsis is most often identified in the emergency department (ED) setting due to 87% of cases beginning in the community (Sepsis Alliance, 2022). National compliance with SEP-1 is 50% despite a …

How Emotional Intelligence Influences Students’ Life Satisfaction During University Lockdown: The Chain Mediating Effect Of Interpersonal Competence And Anxiety, Yuyang Zhao, Biao Sang, Cody Ding

Education Sciences and Professional Programs Faculty Works

Students’ life satisfaction is an essential reflection of their well-being, particularly during challenging times. The COVID-19 pandemic, a global catastrophe, has had an immeasurably negative impact on individuals’ daily lives. It has also provided an opportunity to investigate the factors contributing to students’ life satisfaction during such difficult times. Considering the unique characteristics of these university students, the current study examines the impact of emotional intelligence (EI) on students’ life satisfaction, as well as the direct and sequential mediating effects of interpersonal competence and anxiety on this relationship. A total of 297 university students in Shanghai, China, participated in the …

Association Of Neonatal And Maternal Nasal Microbiome Among Neonates In The Intensive Care Unit., Shaoming Xiao, Wei Zhou, Ryan Caldwell, Slade Decker, Julia Oh, Aaron M Milstone

Faculty Research 2024

The neonatal nasal microbiota may help protect neonates in the neonatal intensive care unit from pathogen colonization and infection. This preliminary study characterized the biodiversity of nasal microbiota comparing neonates in the neonatal intensive care unit and their mothers, highlighting the potential of strain sharing between mother-neonate pairs.

Infectious Disease Mapping And Spread Prevention Using An Agent-Based Modeling Technique, Michael Kama

3 Minute Thesis Competition

No abstract provided.

Reimagining Judicial Review Of Student Requests For Remote Instruction As An Ada Accommodation In Higher Education, Hannah E. Auten

Chicago-Kent Law Review

No abstract provided.

Lupin Root Diseases - Diagnosis And Management, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Root, hypocotyl and stem base diseases can be significant problems in lupin crops, reducing stand density, plant vigour and yield. Root disease is present in nearly all narrow leafed lupin (Lupinus angustifolius) paddocks but in the majority of paddocks has only a small impact on crop development. However, in paddocks where high levels of root rot occurs, plant establishment, seedling vigour and crop yield can be significantly affected.

When a root disease is present in a crop very little can be done to manage it in that cropping season. It is therefore vital that the cause is correctly identified to …

Decreasing Sepsis Mortality With A Standard Screening Tool, Bailey Kee, Trina Smith, Katie Anderson, Ryan Huerta, Dr. Rachel Valentz, Dr. Jamie Larie Kitchens

Anna Vaughn School of Nursing Undergraduate Work

Sepsis is a life-threatening condition that affects 1.7 million people annually. Since sepsis is so prevalent and deadly, this necessitates an evaluation of the current standard of care regarding tools evaluating the early identification of sepsis. The research presented compares current sepsis screening tools: qSOFA, MEWS, and SIRS. The question posed for this systematic review was, “Which screening tool is the most effective in the early identification of sepsis?” Multiple methods were used in the discovery process, the most common being searching online databases for relevant scholarly articles, particularly utilizing the Oral Roberts University Library and Google Scholar. As a …

Oceanic Breakthroughs: Marine-Derived Innovations In Vaccination, Therapy, And Immune Health, Chiara Gamberi, Chad L. Leverette, Alexis C. Davis, Moayad Ismail, Ilaria Piccialli, Nicola Borbone, Giorgia Oliviero, Caterina Vicidomini, Rosanna Palumbo, Giovanni N. Roviello

Biology

The vast, untapped potential of the world’s oceans is revealing groundbreaking advancements in human health and vaccination. Microalgae such as Nannochloropsis spp. and Dunaliella salina are emerging as resources for recombinant vaccine development with specific and heterologous genetic tools used to boost production of functional recombinant antigens in Dunaliella salina and Nannochloropsis spp. to induce immunoprotection. In humans, several antigens produced in microalgae have shown potential in combating diseases caused by the human papillomavirus, human immunodeficiency virus, hepatitis B virus, influenza virus, Zika virus, Zaire Ebola virus, Plasmodium falciparum, and Staphylococcus aureus. For animals, microalgae-derived vaccine prototypes have been developed …

Seasons Of Kawasaki Disease During The Covid-19 Pandemic., Todd T. Nowlen, Ashraf S. Harahsheh, Geetha Raghuveer, Simon Lee, Anji T. Yetman, Nagib Dahdah, Michael A. Portman, Supriya S. Jain, Michael Khoury, Selemet Tierney, Cedric Manlhiot, Pedrom Farid, Brian W. Mccrindle

Manuscripts, Articles, Book Chapters and Other Papers

The incidence of Kawasaki Disease has a peak in the winter months with a trough in late summer/early fall. Environmental/exposure factors have been associated with a time-varying incidence. These factors were altered during the COVID-19 pandemic. The study was performed through the International Kawasaki Disease Registry. Data from patients diagnosed with acute Kawasaki Disease and Multiple Inflammatory Syndrome-Children were obtained. Guideline case definitions were used to confirm site diagnosis. Enrollment was from 1/2020 to 7/2023. The number of patients was plotted over time. The patients/month were tabulated for the anticipated peak Kawasaki Disease season (December-April) and non-peak season (May-November). Data …

Community Quarantines And Social Protection Programs: Philippine Pandemic Response Viewed Through The Human Security Framework, Leslie Advincula-Lopez, Jessica Sandra R. Claudio, Haraya Marikit C. Mendoza

Development Studies Faculty Publications

No abstract provided.

A Method For Teaching Biostatisticians To Write And Critique Specific Aims, Jesse D. Troy, Gregory P. Samsa, Megan L. Neely, Steven C. Grambow, Sarah Peskoe, Emily Slade, Gina Maria Pomann

Biostatistics Faculty Publications

This article describes the design of a single instructional module on writing and critiquing the Specific Aims (SA) section of a grant proposal for a biomedical research study. It begins by discussing the goals and learning objectives for the module. Then, it discusses the typical structure of a SA section to orient readers to the core content. This method is rooted in using an established framework for scientific writing, which is presented in brief, along with examples of how it applies to writing the SA section. Then, the structure of the instructional module is described, including the exercises for participants. …

Research Gaps And Priorities For Quantitative Microbial Risk Assessment (Qmra), Kerry A. Hamilton, Joanna Ciol Harrison, Jade Mitchell, Mark Weir, Marc Verhougstraete, Charles N. Haas, A. Pouyan Nejadhashemi, Julie Libarkin, Tiong Gim Aw, Kyle Bibby, Aaron Bivins, Joe Brown, Kara Dean, Gwyneth Dunbar, Joseph N.S. Eisenberg, Monica Emelko, Daniel Gerrity, Patrick L. Gurian, Emma Hartnett, Michael Jahne, Rachael M. Jones, Timothy R. Julian, Hongwan Li, Yanbin Li, Jacqueline Mac Donald Gibson, Gertjan Medema, J. Scott Meschke, Alexis Mraz, Heather Murphy, David Oryang, Emmanuel De Graft Johnson Owusu-Ansah, Emily Pasek, Abani K. Pradhan

Faculty Publications

The coronavirus disease 2019 pandemic highlighted the need for more rapid and routine application of modeling approaches such as quantitative microbial risk assessment (QMRA) for protecting public health. QMRA is a transdisciplinary science dedicated to understanding, predicting, and mitigating infectious disease risks. To better equip QMRA researchers to inform policy and public health management, an Advances in Research for QMRA workshop was held to synthesize a path forward for QMRA research. We summarize insights from 41 QMRA researchers and experts to clarify the role of QMRA in risk analysis by (1) identifying key research needs, (2) highlighting emerging applications of …

Roger Williams University Law Review Symposium: Trauma-Informed Lawyering: Approaches To Advocating For Diverse Populations November 15, 2024, Roger Williams University School Of Law

School of Law Conferences, Lectures & Events

No abstract provided.