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Tnf Prevents Establishment Of Anti-Tumor Immunity And Elucidates Toxicities Following Myxoma Virus Based Oncolytic Virotherapy, Miriam Beatriz Valenzuela Cardenas

Biomedical Sciences ETDs

Tumor Necrosis Factor Alpha (TNF) can lead to tumor regression through its direct cytolytic activity, yet it has also been implicated to facilitate tumor progression. This scenario complicates the efficacy and applicability of TNF based therapeutics as treatment for malignancies. In the context of oncolytic virotherapy (OV) which uses replicating viruses to treat tumors and acts by triggering production of pro-inflammatory cytokines, exploring such mechanisms is vital. Here we show that a Myxoma based oncolytic virus (vPD1/IL12) can induce large amounts TNF. The presence of TNF in the context of vPD1/IL12 plays a detrimental role both for tumor regression by …

Testing Vivo-Morpholino Mediated Gene Knockdown Of Stat6, Spi1b, And Hnf4Α In Adult Threespine Stickleback, Stella Dipippo

Honors Scholar Theses

The fibrotic immune response to the cestode parasite, Schistocephalus solidus, varies among threespine stickleback populations. Fibrosis suppresses parasite growth but has costly effects on the fish. Previous genomic studies in stickleback have suggested potential roles of Spi1b, STAT6, and HNF4α in modulating fibrosis severity, but there is presently no evidence for this in-vivo. We used antisense vivo-morpholino oligonucleotides (MOs) to attempt to knockdown the expression of each gene in the liver, spleen, and intestine of adult stickleback. Vivo-MOs have been proven effective in other species of teleost fish, as well as in mice and humans, but …

In Silico-Predicted Cytokeratin Fragment 21-1 (Cyfra 21-1) Immunogenic Epitopes For The Early Detection Of Nasopharyngeal Carcinoma, Brian Umbu Rezi Depamede, Bachti Alisjahbana, Sulaiman Ngongu Depamede, Sanny Hafidhoh, Siti Nururrohmah, Ilham Ngongu Tryawan, Muhammad Yusuf

Chimica et Natura Acta

Nasopharyngeal Carcinoma, an aggressive cancer in the head and neck region is mostly diagnosed at an advanced stage and thus has a poor prognosis. Cytokeratin Fragment 21-1 (CYFRA 21-1) is one of the oncomarkers discovered in saliva. For developing a diagnostic kit, CYFRA 21-1 antibodies and immunogens are needed. Natural CYFRA 21-1 immunogen is difficult to obtain, so it must be made in-silico using bioinformatics. We aim to predict CYFRA 21-1 immunogenic epitope to produce antibodies polyclonal against CYFRA 21-1, which can be used to develop NPC diagnostics. The immunogenic epitopes were predicted and chosen based on antigenicity, surface accessibility, …

Biomedical Potential Of Natural Products From Selected Tanzanian Flora: A Review, Stephen S. Nyandoro, Joan J.E. Munissi

Tanzania Journal of Science

Natural products have been used for treatment of various diseases for thousands of years and served as sources of drug lead compounds for the improvement of livelihood. This paper presents a review on the biomedical potentials of selected natural products isolated from eight plant species indigenous to Tanzania. The review covers research work published between 2010 and 2023, and identifies 33 natural products with different pharmacological properties from Tanzanian plants. These bioactive natural products are discussed with other similar compounds isolated elsewhere from the same or different plant species to get further insights on the potential application in modern medicine …

Dental Hygiene Programs’ Use Of Oral Health Literacy Techniques For Special Needs Patients And Caregivers, Socorro D. Tejeda Diaz

Dental Hygiene ETDs

This study examined oral health literacy communication techniques in dental hygiene programs across the U.S. for special needs patients and their caregivers. The study surveyed 46 U.S. dental hygiene program directors on communication techniques, degrees offered, and subject areas. Two-sample t-tests compared differences in communication techniques between AAS and BAS and subject areas. Most respondents routinely employed printed materials with 2 or 3 concepts, speak slowly, and simple language. When comparing the variances in communication techniques offered in AAS and BAS, we observed a t-statistic of 2.06 with a corresponding p-value of 0.54. This suggests that the mean communication techniques …

In Vitro Screening Of Potential Inhibitors Against Barmah Forest Virus, Karthika Raj Peringoth

Honors Capstone Projects and Theses

No abstract provided.

Vaccines On The Move And The War On Polio, Laura Muñoz-Blanc, Federico Fabio Frattini

Fondazione Eni Enrico Mattei Working Papers

The rising number of refugees and internally displaced people (IDPs) presents new challenges for vaccine distribution and the spread of diseases. How do forcibly displaced population inflows affect infectious diseases incidence in host communities? Can a policy intervention that vaccinates children during their migration mitigate the impacts? To answer these questions, we examine the Pakistani mass internal displacement from the conflict-affected Federally Administered Tribal Areas in 2008. Using a difference-in-differences approach, we compare new polio cases in districts near and far from the conflict zone before and after 2008. The spatial distribution of districts relative to the historical region of …

Early Host Defense Against Virus Infections, Søren R. Paludan, Thomas Pradeu, Andreas Pichlmair, K. Brad Wray, Jacob Giehm Mikkelsen, David Olagnier, Trine H. Mogensen

Presidential Fellows Articles and Research

Early host defense eliminates many viruses before infections are established while clearing others so they remain subclinical or cause only mild disease. The field of immunology has been shaped by broad concepts, including the pattern recognition theory that currently dominates innate immunology. Focusing on early host responses to virus infections, we analyze the literature to build a working hypothesis for the principles that govern the early line of cellular antiviral defense. Aiming to ultimately arrive at a criteria-based theory with strong explanatory power, we propose that both controlling infection and limiting inflammation are key drivers for the early cellular antiviral …

Improving Immunization Rates In Children Under Two Years Of Age In Linn County, Kansas Through Nursing Education, Heather L. Webber

Doctor of Nursing Practice Scholarly Project

Immunizations are one of the most beneficial preventive health measures available to children under two years of age. Failing to receive these preventative immunizations during these crucial years could result in the child developing serious diseases that may lead to long term disability or even be fatal. By increasing immunization rates, children will be more protected against common childhood diseases which will allow them to grow and thrive. The purpose of this scholarly project was to identify ways to improve vaccination rates in children under two years of age at specific clinics in Linn County, Kansas, using healthcare professional education. …

The Efficacy And Safety Of Nirsevimab In The Prevention Of Rsv Related Infections In Healthy Infants, Gabrielle Mayo, Suyin Ballard

Physician Assistant Capstones, 2020-current

Objective: To assess the efficacy and safety of preventing Respiratory Syncytial virus (RSV) related respiratory illnesses and hospitalization with the use of Nirsevimab, as compared to placebo among infants among healthy early and late preterm infants less than one year of age. Design: Systematic Literature Review

Methods: Searches were done using Pubmed and the search term Nirsevimab in Fall 2023. Records were excluded from analysis if full text was not available, studies other than randomized control trials or if included infants that were not healthy or born before 29 weeks gestation. Results: Of the 3 studies, 2 studies demonstrated reduction …

Discrete Particle Dynamics Models: Computational Aspects And Applications, Yuxuan Wu

Doctoral Dissertations and Master's Theses

Particle dynamics considers discrete particles as Newtonian point masses in diverse domains such as, pedestrian particles in pedestrian movement modeling and molecules in material science modeling. These dynamic modeling approaches share a commonality in computational approach where a series of ordinary differential equations are solved for the particle’s motion and equilibrium under active interactions and boundary conditions. In general, particle dynamics approaches are computationally intensive and address problems that require a vast parameter design space. In this dissertation, a computational paradigm is developed for large-scale particle dynamics modeling and demonstrated by three process design applications, (a) infection risk modeling for …

Practicing Responses To Acute Clinical Troubles: Initiative Through Clinical Education (P.R.A.C.T.I.C.E.) To Improve Medical Emergency Response Increasing Nurse Confidence And Preparedness Through Low-Stakes Clinical Education, Lauren Castelblanco Rn, Viviana Lopez Rn, Nosa Odiase Rn, Everly Pompa Rn

Master's Projects and Capstones

A newly established pediatric outpatient infusion center in Los Angeles does not have immediate access to a Code Blue Team or a Rapid Response Team, and instead relies on the Staff Assist protocol to manage medical emergencies. Via direct interviews, registered nurses at the infusion center report feeling underprepared and lacking confidence to respond to medical emergencies that must be escalated to code blue. Microsystem assessment tools determined the root cause to be limited clinical exposure and limited opportunities for skills development. To address the nurses' concerns, Practicing Responses to Acute Clinical Troubles: Initiative through Clinical Education (P.R.A.C.T.I.C.E.) was implemented …

The Rise Of Artificial Intelligence In Pharmacy: Transforming Medication Management And Patient Care, Gracia Anastasya, Miski A. Khairinisa

Pharmacology and Clinical Pharmacy Research

Artificial intelligence (AI) is rapidly transforming healthcare, with significant implications for pharmacy practice. This review explores the diverse applications of AI in pharmacy, emphasizing its potential to revolutionize medication management, patient care, public health, disease management, and pharmacy workflow efficiency. AI algorithms can analyze a vast amount of patient data, allowing pharmacists to identify potential drug interactions, evaluate medication safety and effectiveness, and offer personalized treatment suggestions. In the realm of public health, AI supports disease management through epidemiological monitoring and targeted interventions. Additionally, AI-driven robotic dispensing systems and automated inventory management enhance pharmacy workflow efficiency by streamlining operations and …

A Kid's Guide To Infectious Disease, Abby Carroll

Honors Theses

A Kid’s Guide to Infectious Disease is an educational illustrated book intended for young pediatric patients, ages three to five. This project was inspired by my personal interests, involvement at the University of Mississippi, and experience as a medical assistant. Over the past couple of years, I have had the opportunity to work as a medical assistant, interacting with many pediatric patients and their families at HealthPointe Primary Care. As a pre-physician assistant student studying biology, I was inspired to create a resource for these kids by both my classes at the University of Mississippi and my passion for pediatric …

The Evidence Is In: Breast Implants Are Making People Sick Increasingly Women Find When They Have Their Implants Removed, Their Symptoms Improve—Or Disappear., Pamela J. Appea

Capstones

Over the years, breast implants have been associated with a wide range of health issues, including cancer and autoimmune diseases, but surprisingly these issues are not well known to the public. In 1992, health concerns led the FDA to halt the use of silicone gel breast implants for cosmetic surgeries, although implants containing saline remained available (it was during this period that the Oprah segment that Gmitro remembered ran on TV). In 2006, after more research, which some experts believe was insufficient, the FDA re-approved the use of silicone implants. In 2019, a novel “textured” breast implant manufactured …

Baby-Friendly Hospital Initiative: Becoming Baby-Friendly Designated, Krystal Angelique Mora

Master's Projects and Capstones

Section I: Abstract

Problem Despite efforts to increase breastfeeding rates, the influence of formula companies has contributed to the decrease in rates, affecting the health outcomes of infants. In response, the Baby-Friendly Hospital Initiative (BFHI) introduced standardized education for nursing staff to support infant growth and development. Context Hospital A Birth Center is a 33-bed culturally diverse unit that provides care to mothers in Northern California, delivering approximately 7,400 babies each year and helping patients transition into motherhood. Aim The quality improvement project aims to enhance the retention of BFHI-aligned education provided during hospitalization by 26.2%, raising retention rates among …

Cardiac Effects And Comorbidities Of Neurological Diseases, Bi̇lgi̇n Öztürk

Turkish Journal of Medical Sciences

Neurological disorders encompass a complex and heterogeneous spectrum of diseases affecting the brain, spinal cord, and peripheral nervous system, each presenting unique challenges that extend well beyond primary neurological symptoms. These disorders profoundly impact cardiovascular health, prompting an intensified exploration into the intricate interconnections between the neurological and cardiovascular systems. This review synthesizes current insights and research on cardiovascular comorbidities associated with major neurological conditions, including stroke, epilepsy, Parkinson’s disease, multiple sclerosis (MS), and Alzheimer’s disease.The cardiovascular sequelae of these neurological disorders are multifactorial. For instance, strokes not only predispose individuals to arrhythmia and heart failure but also exacerbate pre-existing …

Infant Mortality Data: Missing Pieces To Prevention In Lesotho, Jacinda Croissant

Master's Projects and Capstones

Lower-middle-income countries (LMICs) like Lesotho lack complete and quality infant mortality data. Without infant mortality data, it can be challenging to develop public health education, programming, and policies to address preventative infant deaths in specific populations (Rao et al., 2004). A literature review identified strategies to improve infant mortality data in LMICs. Through a community engagement model and digital storytelling, community members can gain awareness, begin an ongoing conversation about local public health issues, and participate in an improved data collection system. Infant mortality is often used as an indicator of health for a population; improved infant mortality data can …

A Home Is A Human Right: Homelessness In Sacramento, Alexa Renée Colvin

Master's Projects and Capstones

Homelessness is a public health crisis in California and needs to be addressed. Homelessness directly impacts health outcomes through increased barriers of care and unmet needs. It affects people in all walks of life, but the risk of experiencing homelessness increases within marginalized communities. The solution to end homelessness is not straightforward, and requires collaboration across federal, state, and local organizations. A literature review was conducted to understand what the homelessness crisis looks like broadly in California, and more specifically in Sacramento, and create informed recommendations. This literature found that implementing a structured and collaborative housing first approach is a …

Baby-Friendly Hospital Initiative: Becoming Baby-Friendly Designated, Joann Chu Zheng

Master's Projects and Capstones

Problem Global breastfeeding rates remain low despite numerous breastfeeding benefits, which poses significant challenges and contributes to adverse infant health outcomes. In response, the Baby-Friendly Hospital Initiative (BFHI) was established to advocate, defend, and uphold breastfeeding encouraging healthy infant development from birth through early childhood. Context Hospital A is in the East Bay with a perinatal unit seeking BFHI certification. A microsystem assessment identified the need to ensure that postpartum nurses deliver accurate and consistent BFHI-aligned education to meet designation requirements. Intervention A standardized patient checklist conforming to baby-appropriate education guidelines was developed to improve the quality and thoroughness of …

Engineering Functionalized Nanomaterials For Targeting And Ablating Biofilms On Surfaces, Dhanush Lakmal Yapa Amarasekara

Theses and Dissertations

Biofilms on both the surface and interior of medical devices pose major challenges, including hindering device performance and serving as infection sources. These biofilms form a protective layer around bacteria, shielding them from the body’s immune system and antibiotics. This makes infections difficult to treat, as the bacteria within the biofilm are resistant to both antibiotics and immune defenses. Additionally, biofilms can induce inflammation and irritation in nearby tissues, leading to further health complications. Antibiotic resistance raises concerns about the emergence of multi-drug resistant (MDR) pathogens. MDR infections are difficult to treat, leading to prolonged hospital stays and the need …

Fisheries Management In Mississippi State-Operated Fishing Lakes: A Review And Look To The Future, Hayden Gregory Funk

Theses and Dissertations

The Mississippi Department of Wildlife, Fisheries and Parks currently manages 18 State Lakes and 17 State Park Lakes to provide public fishing opportunities. My goal was to conduct a comprehensive analysis of monitoring and management activities in State Lakes to enhance understanding of lake dynamics, further develop existing management initiatives, and identify alternative avenues for effective management. To achieve this objective, I have undertaken a comprehensive examination and synthesis of the historical background pertaining to State Lakes and conducted an analysis of pertinent data regarding lake characteristics such as the physical and chemical attributes of the lakes, the features of …

Evaluation Of Current Management Strategies For The Tarnished Plant Bug And Tobacco Thrips In Midsouthern Cotton, Hunter Lane Lipsey

Theses and Dissertations

The tarnished plant bug, Lygus lineolaris (Palisot de Beauvois), is an important economic pest of cotton, Gossypium hirsutum (L.), in the Midsouth region of the United States. An experiment was conducted to determine the impact of insecticide class loss on yield and Lygus populations in the recently commercialized ThryvOn cotton technology. Data indicated no significant yield loss when excluding any currently utilized insecticide class for tarnished plant bug management. An additional objective was to reevaluate the sampling interval necessary to scout ThryvOn cotton for Lygus. No significant differences were observed between a 3 or 7-day sample interval compared to plots …

Description And Influence Of Diseases On The East Mississippi Catfish Industry, And The Role Of Clay Minerals, Iron, And Aluminum Salts In The Susceptibility Of Channel Catfish To Aeromonas Hydrophila And Edwardsiella Ictaluri, Mark Alan Peterman

Theses and Dissertations

In 2014, a virulent clonal group of Aeromonas hydrophila (VAH) was the predominant disease impacting the east Mississippi (EMS) commercial catfish industry. The EMS aquatic ambulatory service observed an area not prone to VAH outbreaks. In addition, frequent underestimations of the scope and economic impact of the EMS catfish industry and its diseases warranted a descriptive effort. Therefore, the EMS catfish industry, its economic impact, the diseases of this region and their economic impact were described. Further, differences in water and geological chemistry of the area not prone to VAH outbreaks, and the sensitivity of VAH and Edwardsiella ictaluri to …

Anemia And Adherence To Weekly Iron-Folic Acid Supplementation Among Adolescent Girls In A Stunting Locus Of Ambon City, Indonesia, Yudhie D. Tando, Christiana R. Titaley, Ritha Tahitu, Elpira Asmin, Liyani S. Sara

Journal of Health Research

Background: Anemia remains a major public health concern among adolescent girls in Indonesia. To address this, weekly iron-folic acid (IFA) supplementation has been implemented nationwide. This study examined factors associated with anemia and adherence to IFA supplementation among adolescent girls in three senior high schools within the Poka-Rumah Tiga Health Centers' catchment area in Ambon City, Indonesia.

Methods: A cross-sectional survey was conducted in August 2022 involving 522 female students from three senior high schools in Ambon City. Factors associated with anemia and adherence to weekly IFA supplementation were examined using logistic regression.

Results: A high prevalence of anemia (49.23%) …

​​Living With Parkinson’S During Covid-19: A Survey Of Parkinson’S Patients During Covid-19​, Sia Shaila Pilgaonkar

Undergraduate Theses

The COVID-19 pandemic has significantly impacted individuals with Parkinson's disease (PD), raising concerns about exacerbation of symptoms and vulnerability of the patients. This project first reviews existing literature on the interconnections between COVID-19 and PD, focusing on the physiological, psychological, and treatment-related challenges faced by patients. Then it analyzes survey data examining increased severity of COVID-19 in individuals with PD, alongside the literature researching potential mechanisms linking the two, such as inflammation and neurodegeneration. The survey’s key areas of focus included symptom management, treatment satisfaction, the impact of PD on daily living, and the impact of COVID-19 on motor and …

Elevated Ambient Temperature Associated With Reduced Infectious Disease Test Positivity Rates: Retrospective Observational Analysis Of Statewide Covid-19 Testing And Weather Across California Counties., Nicholas Wing-Ping Kwok, Joshua Pevnick, Keith Feldman

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: From medication usage to the time of day, a number of external factors are known to alter human body temperature (BT), even in the absence of underlying pathology. In select cases, clinical guidance already suggests the consideration of clinical and demographic factors when interpreting BT, such as a decreased threshold for fever as age increases. Recent work has indicated factors impacting BT extend to environmental conditions including ambient temperature. However, the effect sizes of these relationships are often small, and it remains unclear if such relationships result in a meaningful impact on real-world health care practices.

OBJECTIVE: Temperature remains …

Why Law "Beyond The State" Need Not Be A Threat To Democratic Values, Paul Schiff Berman

Buffalo Law Review

Discussions of “law beyond the state” almost inevitably run into objections from those who believe that sub- or supranational legal orders necessarily subvert local democratic governance. Self-proclaimed populists and others express concern that the “will of the people” will be unduly subjected to the dictates of “cosmopolitan elites”1 or local factions, or corporate capture. These objections range across the political spectrum. Those on the right tend to focus on concerns that transnational orders will impose human rights or immigration rules on a national polity, while those on the left worry about trade regimes that might impose local labor or environmental …

Safety, Immunogenicity, And Efficacy Of A Recombinant Vesicular Stomatitis Virus Vectored Vaccine Against Severe Fever With Thrombocytopenia Syndrome Virus And Heartland Bandavirus, Philip Hicks, Tomaz B. Manzoni, Jonna B. Westover, Raegan J. Petch, Brianne Roper, Brian B. Gowen, Paul Bates

Animal, Dairy, and Veterinary Science Faculty Publications

Background: Severe fever with thrombocytopenia syndrome virus (STSV) is a recently emerged tickborne virus in east Asia with over 18,000 confirmed cases. With a high case fatality ratio, SFTSV has been designated a high priority pathogen by the WHO and the NIAID. Despite this, there are currently no approved therapies or vaccines to treat or prevent SFTS. Vesicular stomatitis virus (VSV) represents an FDA-approved vaccine platform that has been considered for numerous viruses due to its low sero-prevalence in humans, ease in genetic manipulation, and promiscuity in incorporating foreign glycoproteins into its virions. Methods: In this study, we developed a …

Systemic Antibiotic Selection In Skin And Soft Tissue Infections, Shafira Anindya Purnawan, Windy Keumala Budianti, Sandra Widaty

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Antibiotics are used in daily practice. To properly select antibiotics, it is important to pay attention to the definitive diagnosis, class of antibiotic, dose, interval, route of administration, and exact duration of use.

Discussion: The World Health Organization (WHO) categorizes antibiotics into three groups: Access, Watch, and Reserve—known as the AWaRe classification—to help guide appropriate usage and combat antibiotic resistance. The Gyssens flowchart serves as a valuable tool for clinicians to qualitatively evaluate antibiotic utilization. In skin and soft tissue infections (SSTIs), treatment strategies are tailored according to the characteristics of the infection, including purulence, necrosis, and overall severity. …