Digital Commons Network^™

Food Transformation Technology In Paolo Bacigalupi's The Windup Girl And What It Means For Us, Young-Hyun Lee

Kritika Kultura

This article argues that a stage in history has come where advanced technology, especially that of genetically engineered foods and animals, is quickening the humankind’s downfall. Bacigalupi represents this well in The Windup Girl, a futuristic novel that looks with great focus at the transformation of food and animals in the twenty-third century. In our own world, climate change is creating urgent food issues. Genetically Modified Organism (GMO) technologies, having been initially introduced to overcome dire food shortages, have turned out to have many negative side effects, both in our own world and in the fictional world of The Windup …

Accumulated And Accumulable Cultures: The Case Of Public And Private Initiatives Toward K-Pop, Jimmyn Parc, Hwy-Chang Moon

Kritika Kultura

When it comes to the promotion of culture, many tend to highlight the vital role of public initiatives. This idea is based on the common perception that culture is part of the nation- state. This belief also stems from the confusion between two types of culture. To address such misperceptions, this paper emphasizes a distinction between accumulated and accumulable cultures: The former is associated with the nation-state and local conditions. Given that it has formed over a long period of time with the accumulation of related cultural practices, the need to protect it is strong. On the other hand, accumulable …

Hyperglycemia Causes Differential Change In Macrophage Population In The Lacrimal Gland, Conjunctiva And Cornea, Saleh Alfuraih, Amy Tran, Lois Kim, Rais Ansari, Ajay Sharma

Pharmacy Faculty Articles and Research

Background: Due to its location, the ocular surface is exposed to environmental microbes. Innate immune cells including macrophages are first line defense against infections. In vitro exposure to high glucose as well as diabetes-associated hyperglycemia has been shown to affect innate immune cell function and population. The present study was designed to examine the effect of diabetes-associated hyperglycemia on the lacrimal gland, conjunctiva and cornea macrophage population, phenotypic changes and cytokines/chemokines.

Methods: Mouse model of Streptozotocin-induced diabetes was used to induce hyperglycemia. Immunostaining for CD11b and F4/80 was performed to stain macrophages in whole mount cornea, conjunctiva and 50 µm …

Achieving Inter- And Transdisciplinarity In Ecohealth: Insights From A Rodent-Borne Disease Project In A Polycrisis Era, Isabelle Arpin, Clémence Massart, Vincent Bourret, Guillaume Castel, Valeria Carolina Colombo, Jana Eccard, Jasmin Firozpoor, Maciej Grzybek, Heikki A. Henttonen, Herwig Leirs, Andrew Mcmanus, Ben Roche, Tarja Sironen, Vincent Sluydts, Peter Stuart, Annetta Zintl, Nathalie Charbonnel

Publications

Introduction: Inter- and transdisciplinary research (ITDR) is increasingly promoted to address “wicked problems”, particularly in health sectors adopting approaches like Ecohealth. Our Ecohealth-inspired project on rodent-borne diseases, initiated just before the COVID-19 pandemic, provided an opportunity to evaluate ITDR implementation.

Methods: We employed a recently developed semi-quantitative evaluation method to measure our project’s success in achieving ITDR and analyzed factors influencing this achievement.

Results: The project showed strengths in system description, team task allocation, and data sharing, but had lower scores in engaging societal actors throughout the project cycle.

Discussion: We identified the underexplored influence of problem wickedness as a …

Reversing Chronic Disease Through Functional Medicine: Acknowledging Privilege And Seeking Justice, Rosalynn A. Vega

Anthropology Faculty Publications

This piece is based on twenty-eight months of digital-auto-ethnographic research. While my research methods included traditional ethnographic research in face-to-face settings and digital ethnography, my personal experience is also embedded in the work. In this piece, you will find “interludes” that provide glimpses into my healing journey. When writing in this autoethnographic register, I provide “thick descriptions” (Geertz 3) of how I experienced illness and recovery. By including my own story, I am acknowledging that the observed and the observer are inextricably intertwined. All ethnography is relational. Ethnographic data results from a trusting relationship between ethnographer and participant. Furthermore, in …

Influenza Knowledge And Barriers To Vaccination In Immunosuppressed Patients In The Pediatric Rheumatology Clinic., Julia G. Harris, Leslie Favier, Jordan T. Jones, Maria Ibarra, Michael J. Holland, Emily Fox, Kelly Jensen, Ashley K. Sherman, Ashley M. Cooper

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Most patients with a pediatric rheumatic disease are at increased risk of influenza due to immunosuppressive medication use. Despite initial quality improvement efforts, our influenza vaccination rate plateaued at 72%, which prompted a survey of patients and families to assess provider vaccine recommendations, influenza knowledge, and barriers to influenza vaccination.

METHODS: Patients on immunosuppressive medication or their parent were eligible to complete a survey between July 2019 and January 2020. Survey questions assessed demographics, rheumatology diagnosis, immunosuppressive medication(s), influenza vaccination recommendation, patient/parent influenza knowledge, and barriers to influenza vaccination. Influenza vaccination rates for immunosuppressed patients were acquired each influenza …

Prenatal Identification Of Intracardiac Mass Expedites Surgical Management Of Capillary-Venous Malformation, Derek M Norton, Mounica Y Rao, Jianhong Zhang, M John Hicks, Anitha Parthiban, S Kristen Sexson Tejtel

Faculty, Staff and Students Publications

Fetal and neonatal cardiac tumors are rare and often benign. Clinical presentation is primarily related to mass effect, pericardial effusion or arrhythmia. Prenatal detection can assist with risk assessment and inform optimal delivery plan and postnatal management. We report a fetus with a right atrial mass discovered in the third trimester. After successful surgical resection, pathology confirmed the mass to be a capillary-venous malformation, which are rare and challenging to diagnose. The true incidence of these vascular malformations within cardiac spaces is difficult to discern given the historic classification of numerous different vascular malformations under the umbrella term hemangioma.

Prevalence Of Coronavirus And Rotavirus In Dairy Calves In North-Central Of Algeria, Dadda Anes, Mohamed Cherif Abdellah, Khelef Djamel

The Thai Journal of Veterinary Medicine

Coronavirus and Rotavirus have been reported as the two main pathogens implicated in neonatal gastroenteritis in calves. The aim of this study is to provide descriptive and analytical epidemiological data and to evaluate the influence of infection with these two viruses on the onset of diarrhea in calves less than 60 days old. In our study, we included 35 dairy cattle farms in the north-central part of Algeria from January 2019 to December 2021. We analyzed 152 samples using the Copro-ELISA test, which revealed a prevalence of 10.53% and 9.87% for Rotavirus and Coronavirus, respectively. The analysis of the results …

Effects Of Deliberate Practice On Psychomotor Skill Retention In Nursing Students, Annette Oberhaus

School of Nursing Faculty Publications

Psychomotor skills are considered a foundational block for nursing education, yet the approach to teaching these skills varies from program to program.

The goal of this quality improvement project is evaluation of the effects of a systematic change in the method of instructing nursing students in psychomotor skills. The hypothesis is that the use of Deliberate Practice for instruction will promote long-term skill proficiency and retention.

Emergency Vehicle Dispatching Model Considering Demand Urgency And Delivery Fairness, Long Kejun, Liu Jia, Gao Zhibo, Chen Suqian, Zhang Zhonggen

Journal of China & Foreign Highway

In emergency vehicle dispatching after unexpected events，it is crucial to prioritize critical nodes with high demand urgency while minimizing excessive delivery delays at other nodes to prevent secondary impacts.On this basis，this study developed an emergency vehicle dispatching model that considered demand urgency and delivery delay fairness.Firstly，the entropy weight-TOPSIS method was used to calculate the demand urgency for each node，and a delivery delay balance index was introduced to minimize disparities in delivery delays between nodes.Secondly，a multi-objective optimization model was established with total delivery time，overall cost，and delivery delay balance as objectives，while considering constraints such as inventory levels at distribution centers and route …

Bat Activity Across Urban Forest Plantings In Lexington, Kentucky, Grayson Marie Collier

Online Theses and Dissertations

Urbanization has led to major forest loss and negatively impacts ecosystem services. Urban reforestation efforts, such as Reforest the Bluegrass (RTB) in the Lexington-Fayette metropolitan area of Kentucky, have been implemented to address these negative effects, and to create habitat for forest-dependent wildlife such as bats. My research focused on assessing differences in bat activity across a 20-year chronosequence of RTB sites. Acoustic detectors were deployed across 10 different-aged plantings at 60 randomly-defined detector locations. Each planting was surveyed across 8 sampling periods from May – August 2023. Each recording session spanned ca. 7 consecutive nights, yielding a total of …

Barry Conservation Camp Health Form, Andy Schafermeyer

UNH Cooperative Extension

No abstract provided.

Clover (Clostridium Difficile Vaccine Efficacy Trial) Study: A Phase 3, Randomized Trial Investigating The Efficacy And Safety Of A Detoxified Toxin A/B Vaccine In Adults 50 Years And Older At Increased Risk Of Clostridioides Difficile Infection, Curtis J Donskey, Erik R Dubberke, Et Al.

2020-Current year OA Pubs

BACKGROUND: Clostridioides difficile infection (CDI) causes substantial mortality and healthcare burden. We assessed the detoxified toxin-A/B PF-06425090 vaccine for primary CDI prevention.

METHODS: This phase 3 observer-blinded study randomized (1:1) ≥50-year-olds at increased CDI risk (N = 17 535) to receive 3 PF-06425090 or placebo doses (0, 1, and 6 months). Primary end points were first CDI episode (≥3 unformed stools within 24 hours; central laboratory-confirmed toxin A/B positive) ≥14 days post-dose 3 (PD3; first primary) and post-dose 2 (PD2; second primary). CDI duration, need for CDI-related medical attention (secondary end points), and antibiotic use (post hoc analysis) PD3 were …

Corynebacterium Minutissimum As A Rare Cause Of Tibial Osteomyelitis: A Case Report And Literature Review, Ayub Ansari, Dania Shoaib, Maher Asfour, Xiyue Wang, Pooja Sharma

Student Publications

Osteomyelitis is commonly caused by pathogens like Staphylococcus aureus, but rare organisms such as Corynebacterium minutissimum, typically associated with superficial skin infections, can also be implicated. Recognizing these atypical pathogens presents diagnostic and therapeutic challenges, especially in the presence of orthopedic hardware. We conducted a literature review yielding 25 studies and encompassing 797 patient cases, which highlights the emerging role of Corynebacterium species in osteomyelitis, particularly following trauma or surgical interventions. A 72-year-old man with a history of chronic right tibia and fibula fractures from a motor vehicle accident presented with progressively worsening leg pain over six months. …

Gene-Environment Interactions In Non-Alcoholic Fatty Liver Disease: Insights From Mexican American Populations, Eron G. Manusov, Vincent P. Diego, Marcio Almeida, Jacob Galan, Auwal A. Bala, Marco Arriaga, Natasha Garcia-Rodriguez, Renee Hernandez, Satish Kumar, John Blangero, Sarah Williams-Blangero

School of Medicine Publications

Nonalcoholic Fatty Liver Disease (NAFLD) is a prevalent and complex condition influenced by both genetic and environmental factors. This chapter explores the genotype-by-environment interactions that contribute to the development and progression of NAFLD in the Mexican American population. Using advanced genetic epidemiology and bioinformatics approaches, we investigated how specific genetic variants interact with environmental factors such as depression, acculturation stress, and social determinants of health, to influence NAFLD risk and severity. Our findings reveal significant genotype-by-environment interactions for key NAFLD-related traits, including HbA1c, AST/ALT ratio, and steatosis-controlled attenuation parameter (CAP). We also discuss the application of cutting-edge proteomic and transcriptomic …

Skin Lesions, Weight Loss, And Facial Swelling After A Hand Injury, Yuriko Fukuta, Cindy Qinyang Wu, Todd Michael Lasco, Abdul Hafeez Diwan

Faculty, Staff and Students Publications

No abstract provided.

Pleural Empyema: Etiology And Pathogenesis, Daniel M Musher, Sherwood Gorbach, Joshua Fierer

Faculty, Staff and Students Publications

No abstract provided.

Comparing Multivalent Cross-Linked Sodium Alginate/ Montmorillonite Beads Containing Curcumin Or Cayenne Pepper As Drug Carriers And Their Antimicrobial Resistance, Shionainn Traynor, Shubham Sharma

SURE Journal: Science Undergraduate Research Experience Journal

The aim of the following work was to investigate and compare curcumin and cayenne pepper in microbeads composed of sodium alginate (SA) crosslinked with montmorillonite (MMT) to act as drug carriers and their antimicrobial resistance. The microbeads were prepared through ion-exchange in multivalent solutions of CaCl₂, MgCl₂ and AlCl₃. The microbeads were characterized by Scanning Electron Microscopy (SEM), Energy Dispersive X-ray analysis (EDX) and the time required for intercalation of curcumin and cayenne pepper with MMT. Simulated intestinal fluid (pH 7.3) and gastric fluid (pH 1.2) at 37°C were used for comparison in swelling studies. …

Mathematical Modelling Of Disease Outbreak, Favour Christian, Matthew Molloy

SURE Journal: Science Undergraduate Research Experience Journal

Establishing a model framework for more research necessitates a thorough understanding of the causes, distribution, prevalence, and evolution of infectious illnesses. The main mathematical concept used in this modelling simulation is ordinary differential equations (ODEs). The purpose of this study was to investigate the significance of the many criteria linked to a zombie virus spread. The zombie framework provides an accessible and relatively simple representation of the nature of infectious disease spread, allowing for tractable assumptions and the development of more complex situations.

The models are designed around a zombie outbreak in which the zombie virus is spread through a …

Editorial - Sure Journal Vol 6, Anne M. Friel, Eva Campion, Sinead Loughran

SURE Journal: Science Undergraduate Research Experience Journal

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Identification Of Conserved Eukaryotic Gene Products In Novel Mycobacteriophage, Brandon Mar, Jade Coxon, Lily Esterline, Sydney Clifford, Gabriella Burke, Mallory Motz, Alaina Gartner, Kioni Bush, James Lin, Lizzie Adams, Sophia Palant

The Journal of Purdue Undergraduate Research

Bacteriophage, a type of virus that infects bacteria, was discovered 100 years ago, initially isolated with a plaque assay in the 1940s. A mycobacteriophage is a subtype of bacteriophage that specifically infects mycobacteria. Since the introduction of DNA technologies and efforts to identify a plethora of bacteriophages, over 10,000 bacteriophages have been identified with 1,500 sequenced. Bacteriophage discovery has aided in genetic editing techniques, the development of synthetic biology tools, and disease treatment. However, to be able to expand on these capabilities, there is a need to identify more bacteriophages and sequence the genomes of these viruses, as they outnumber …

Next Generation Sequencing Based Profiling Of Genes In Patients With Syndromic Forms Of Retinitis Pigmentosa, Harshavardhini G

Theses and Dissertations

India is one of the largest populations in the world and is estimated to have a high prevalence of Retinitis Pigmentosa (RP). RP is clinically and genetically heterogenous, characterized initially as night blindness, leading to complete vision loss due to retinal degeneration. RP can occur in non-syndromic or syndromic forms, affecting other organs as observed in Bardet Biedl Syndrome (BBS) and Usher syndrome (USH).

BBS is characterized by RP, polydactyly, obesity, renal anomalies and learning difficulties. USH is characterized by RP and sensorineural hearing loss (SNHL), with variable presence of vestibular dysfunction. Nextgeneration sequencing (NGS) has become a cost-effective technology …

Evaluating Pulmonary Tuberculosis Knowledge Deficits Among Nursing Students In The United States, Jamie Lynn Woo

Nursing | Student Research Posters

The healthcare field consistently faces patients with a wide range of diseases and illnesses. Pulmonary Tuberculosis is an infectious lung disease with established tools to prevent, detect, and treat it. Yet, there has been a significant rise in cases within the past year. Amidst this troubling situation, it is crucial that all healthcare workers, nursing students, and nurses in particular, are properly educated on caring for TB patients. This research proposal aims to determine if there are TB treatment knowledge gaps among nursing students in the United States by conducting a 20-question survey utilizing the Likert Scale. If results show …

Effectiveness Of An Improved Leprosy Lakar Training On Knowledge And Skills Among Healthcare Workers In Primary Healthcare In Pahang Malaysia., Nuraihan Zafirah Zainal Abidin

Student Works (2020-2029)

Leprosy, a neglected chronic tropical disease caused by Mycobacterium leprae, poses significant health challenges due to its potential for irreversible disabilities and disfigurement. Adequate leprosy training for healthcare workers (HCWs) is crucial for early detection and prompt treatment, thereby preventing complications and reducing transmission risks. This study aimed to revise and evaluate the effectiveness of leprosy LaKAR* training on knowledge and skills of leprosy among HCWs in primary healthcare in Pahang, Malaysia. The study employed a sequential exploratory, mixed-method design consisting of two phases. Phase 1a was a qualitative study identifying gaps in current LaKAR training among HCWs at …

Feasibility Of A Low-Intensity Intervention To Influence Antibiotic Prescribing Rates Use In Outpatient Settings: A Cluster Randomized Controlled Clinical Trial, Brigid M. Wilson, Sunah Song, Robin L.P. Jump, Federico Perez

Faculty Scholarship

Background. Primary care providers (PCPs) may modify their antibiotic prescription practices if aware of their potentially damaging impact. Methods. We conducted a cluster randomized controlled trial at 12 Veterans Affairs community-based outpatient clinics. PCPs at clinics randomized to the intervention group received quarterly antibiotic use reports with feedback about antibiotics prescribed for acute respiratory infections and adverse event letters alerting about Clostridioides difficile infection or antibiotic-resistant gram-negative bacteria among their patients. The main outcome, antibiotic prescriptions in primary care visits, was compared in the preintervention (April–September 2020), intervention (October 2020 to September 2021), and postintervention periods (September 2021 to September …

Cutaneous Nodules Secondary To Mycobacterium Avium Complex In A Patient With Human Immunodeficiency Virus, Jay Patel, Shannon Sayyadioskoie, Hanna Siatecka, Theodore Rosen

Faculty, Staff and Students Publications

We present a patient with human immunodeficiency virus who developed multiple painful lesions that previously in the past had speciated as Cryptococcus neoformans cutaneously, and in the lung. Despite induction therapy for presumed re-infection, the patient did not improve so a biopsy was performed and this was speciated as Mycobacterium avium complex, with final diagnosis being disseminated Mycobacterium avium complex. This case highlights the importance of considering a broad differential diagnosis for any new lesions regardless of prior culture data.

Whispers In The Wind: Face Mask Sampling For Mycobacterium Tuberculosis Detection In Children With Pulmonary Tuberculosis, Lennard Meiwes, Irina Kontsevaya, Dumitru Chesov, Stela Kulciţkaia, Viola Dreyer, Doris Hillemann, Qiniso Dlamini, Caroline Williams, Michael Barer, Folke Brinkmann, Renate Krüger, Stephanie Thee, Alexander Kay, Anna Maria Mandalakas, Christoph Lange

Faculty, Staff and Students Publications

Background: Recently, face mask sampling (FMS) confirmed detection of Mycobacterium tuberculosis DNA from exhaled breath in adults with tuberculosis. To date, no study has evaluated the use of FMS to detect pulmonary tuberculosis in children. We developed a method for FMS of M. tuberculosis-specific DNA in children and performed a clinical exploration to assess feasibility in children.

Methods: Face masks were spiked, analyzed on GeneXpert-Ultra, quantitative polymerase chain reaction, and targeted next-generation sequencing. Children with pulmonary tuberculosis were asked to wear 3 modified FFP2 masks for 30 minutes as part of an exploratory clinical study.

Results: Experiments with H37Ra M. …

Intouch Week Of December 16, 2024, New York Medical College

InTouch

• New Skyline Auditorium Opens with Ribbon-Cutting Ceremony
• NYMC Secures $200,000 Grant from NYS Division of Criminal Justice
• Medical Students Shape the Future of Medicine Through Research Excellence
• Illuminating Discovery Symposium Showcases Cutting-Edge Innovations in Biomedical Imaging
• Heart and Mind: Studies Unravel Link Between Cardiovascular Disease and Dementia
• NYMC and TU Hosts “Ninety Minutes: The Medical Magazine of the Web”
• Faculty Spotlight: From Pupil to Professor: Alumni Lighting the Way at NYMC

Correlation Of Genogroup I, Genotype 1 (Gi.1) Norovirus Neutralizing Antibody Levels With Gi.1 Histo-Blood Group Antigen-Blocking Antibody Levels, Robert L Atmar, Khalil Ettayebi, Frederick H Neill, Ralph P Braun, James Sherwood, Sasirekha Ramani, Mary K Estes

Faculty, Staff and Students Publications

Background: The in vitro cultivation of human noroviruses allows a comparison of antibody levels measured in neutralization and histo-blood group antigen (HBGA)-blocking assays.

Methods: Serum samples collected during the evaluation of an investigational norovirus vaccine (HIL-214 [formerly TAK-214]) were assayed for neutralizing antibody levels against the vaccine's prototype Norwalk virus/genogroup I, genotype 1 (GI.1) (P1) virus strain. Results were compared with those previously determined using HBGA-blocking assays.

Results: Neutralizing antibody seroresponses were observed in 83% of 24 vaccinated adults, and antibody levels were highly correlated (r = 0.81; P < .001) with those measured by HBGA blocking.

Conclusions: Genogroup I, genotype 1 (GI.1)-specific HBGA-blocking antibodies are a surrogate …

The Burden Mothers Bear: Using The Health Belief Model To Understand How U.S. Mothers’ Intersectional Identities Shape Health Decision-Making During Covid-19, Sydney O'Shay, Kaitlin E. Phillips, Marissa J. Sáez

Publications

The disproportionate impact of COVID-19 on people of color and the burden placed on mothers created a need to better understand how mothers of color made health decisions for their families and communicated these decisions with others during the pandemic. This study investigated how this populations’ intersectional identities played a role in their health decision-making processes and overall experiences during COVID-19. Using the health belief model as a sensitizing concept, we conducted qualitative in-depth interviews with mothers of color across the United States about their lived experiences during the pandemic. Our findings suggest a need for health communicators to address …