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Unm Health Sciences Center Data Book 2024-25

Health Sciences Center Databook (1990-ongoing)

No abstract provided.

Rare Case Of Fungal Osteomyelitis Affecting An Intramedullary Lag Screw, Matthew C. Watterson, Robert T. Rella, Timothy K. Summers, David Michaeli, Jess Mullens

Western Journal of Orthopaedics

Osteomyelitis is an infection of the bone that is most commonly of bacterial origin. Cases of fungal osteomyelitis are rare, and treatment often requires a prolonged course of antimicrobials. The authors report a case of a 72-year old man with fungal osteomyelitis affecting an intracortical lag screw, which was discovered during fixation of the left femoral shaft following an injury that occurred 68 years after placement of the affected lag screw. Chronic osteomyelitis can be indolent and subclinical, with the patient experiencing no signs or symptoms of the disease despite having bone infection for decades. This condition may become clinically …

Structural And Interpersonal Determinants Of Covid-19 Vaccine Uptake In Vulnerable Populations Of The United States, Alyea Wood

Capstone Showcase

Since its introduction in late 2020, the uptake of the COVID-19 vaccine has had the lowest rates in marginalized populations like minorities, elderly, and those of low socioeconomic status. Decreased rates of vaccination uptake in these groups has resulted in increased burden of disease and subsequently higher rates of hospitalization and death. Many inequities in poor COVID-19 health outcomes can be explained by examining common predictive factors that determine vaccination rates in these United States populations. This special article research aims to explore these various predictive factors with the goal to provide targeted strategies to boost COVID-19 vaccination rates, especially …

Probiotics In Clinical Practice: Mechanisms, Applications, And Evidence-Based-Use, Christopher Dimatteo

Capstone Showcase

Probiotics, are live microorganisms that can provide health benefits when consumed in the right amounts, have gained attention as potential therapies for a range of conditions. This article examines the current understanding of probiotics, focusing on how they work, the conditions they might help manage, and the challenges that come with probiotic use. Research shows that probiotics can support gut health by balancing the microbiome, strengthening the intestinal barrier, and influencing the immune system. They have shown promise in conditions like irritable bowel syndrome, antibiotic-associated diarrhea, and some inflammatory disorders. However, their effectiveness depends on the specific strain used, and …

Caspases Protect Against Hyperglycemia Induced Necroptosis-Like Cell Death In Brain Endothelial Cells, Aleena S. Mathew

Theses and Dissertations

Acute diabetes characterized by high spikes in blood glucose levels in association with severe hyperglycemia can lead to an increased risk of ischemic stroke in the brain. To better understand high blood glucose levels, hyperglycemia, in the brain we explored its effects on endothelial cells. Endothelial cells line the inner walls of blood vessels and are directly impacted in hyperglycemia. Brain endothelial cells are a major component of the blood brain barrier (BBB) which tightly regulates the brain’s microenvironment. The type of cell death such as apoptosis, caspase dependent, or necroptosis, caspase independent, can exacerbate diabetes associated complications. There is …

Research News, Publications, 2025, Volume 3, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of July 1 - September 30, 2025.

Oral Hygiene In Hospitalized Patients: Why Nursing Education Matters, Jieun Jugao, Jordan Cusick

Doctor of Nursing Practice Projects

Daily oral care for non-ventilated acute care patients significantly reduces hospital-acquired pneumonia (NV-HAP), dementia risk, reduces length of stay, and enhances patient well-being. Sustaining these outcomes requires ongoing patient-centered education to reinforce adherence and optimize long-term care practices.

Infectious Disease Response Preparedness: Survey Of Small To Medium Residential Universities, Tara Hicks

Doctor of Nursing Practice Projects

Objective: To improve the understanding of strategies implemented by institutions of higher education (IHE) during the COVID-19 pandemic, including how those experiences and resulting knowledge influenced staff confidence and preparedness for future infectious disease events.

Participants: Small to medium undergraduate residential IHE in CA, OR, and WA.

Methods: A Qualtrics survey collected data 1/26/25 – 2/24/25.

Results: Over 50% of respondents identified 7 of 9 preparedness needs as a major to critical need of their IHE. Statistically significant associations were found between IHE conducting a review of actions during COVID-19 and both self-confidence (ρ 0.46, p=0.018) and confidence in …

Exploring Barriers And Opportunities For Formally Integrating A Compensated Community Health Worker Program To Manage Hypertension Into The Healthcare System In Puno, Peru, Miye Dittmann

Doctor of Nursing Practice Projects

Hypertension is the leading cause of preventable mortality worldwide. Community health workers (CHWs) can be potential aids in managing hypertension in Peru. CHWs in Peru are currently not formally practicing or compensated for chronic disease management. Effectiveness of CHWs for hypertension care is being assessed in the The Addressing Hypertension and Diabetes through Community-Engaged Systems (ANDES) Trial. Through semi-structured interviews with healthcare providers and healthcare administrators, this study aims to understand scalability and feasibility integrating CHWs into hypertension management into Peru’s national healthcare system. Following transcription of interviews, inductive and deductive analysis identified key themes and subthemes. Participants described a …

Examining Pyroptosis In Neutrophil-Like Differentiated Hl-60 Cells, Jared Long

Dissertations

The innate immune system is the first line of defense against pathogens. Innate immune cells, such as macrophages and neutrophils, recognize pathogens through the recognition of pathogen associated molecular patterns or damage associated molecular patterns (PAMPS & DAMPS). When a pathogen is recognized, innate immune cells will start clearing the pathogen and secreting pro-inflammatory cytokines, such as interleukin-1β (IL-1β) to initiate the innate immune response. Release of IL-1β occurs through an unconventional secretory pathway triggered by inflammasome activation. Activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome cleaves both pro-IL-1β into mature IL-1β, and full length gasdermin-D (GSDMD) …

Language Barriers In Clinical Trials: Exploring Impacts On Continuity And Participants’ Engagement And Effective Mitigation Strategies, Harsha Ani Das

Master's Theses and Doctoral Dissertations

Clinical trials are crucial for advancing medical knowledge and developing new treatments. However, language barriers can pose significant challenges for participants, particularly in understanding trial procedures, risks, and benefits. Existing policies, guidelines, and studies from 2020 to 2024 identify key challenges in recruiting and retaining non-English-speaking participants. The lack of data on dropout rates highlights the need for improved language services and culturally sensitive communication methods. Findings demonstrate the importance of addressing linguistic disparities to enhance trial inclusivity and success. Innovative strategies to overcome language-related hurdles include the use of professional interpreters, translated materials, and community engagement initiatives. By addressing …

Increasing Nature Connection And Decreasing Climate Change Distress In An Indigenous Population: The Development Of A Traditional Ecological Knowledge Intervention Framework, Olathe Antonio

Graduate Student Theses, Dissertations, & Professional Papers

Research suggests that nature connection is positively correlated with pro-environmental behaviors, concern for the climate, general wellbeing, and subjective levels of climate change distress. Few research studies have examined how to increase nature connectedness without increasing psychological distress. Such research is especially important for those who are disproportionately affected by climate change such as Indigenous Peoples. To address this discrepancy, we developed a culturally-grounded psychological intervention framework based in traditional ecological knowledge (TEK) for Indigenous populations and offered an adapted example for a Navajo population. The intervention was created in collaboration with TEK experts to conceptualize key psychologically-relevant TEK principles, …

Themed Experience & Attractions Academic Symposium 2025 Proceedings, Themed Experience & Attractions Academic Society

Proceedings of the Annual Themed Experience & Attractions Academic Symposium

No abstract provided.

Depletion Of Adipose Stroma-Like Cancer-Associated Fibroblasts Potentiates Pancreatic Cancer Immunotherapy, Joseph Rupert, Alexes Daquinag, Yongmei Yu, Yulin Dai, Zhongming Zhao, Mikhail G Kolonin

Faculty, Staff and Student Publications

This study shows that populations of CAFs have distinct effects on pancreatic cancer progression and shows that depletion of CAFs expressing adipose markers potentiates tumor/metastasis suppression effects of immune checkpoint blockade.

Hca Healthcare Gme Fellowships, Hca Healthcare

All Program Promotional Materials and Information

No abstract provided.

Assessing Impact Of Molecular Diagnostics On Time To Optimal Antibiotic Therapy In Pediatric Staphylococcal Bacteremia, Manith Humchad, Kelly Williamson

Williams Honors College, Honors Research Projects

Timely optimization of antibiotic therapy is critical in pediatric patients with blood infections, particularly those caused by Staphylococcus aureus. This retrospective study evaluated the impact of molecular diagnostics on time to optimal therapy and discontinuation of unnecessary antibiotics at Akron Children’s Hospital from January 2020 to April 2023. Patients with Methicillin-resistant Staphylococcus aureus (MRSA) were more likely to be on appropriate empiric therapy (i.e. vancomycin) before culture results, whereas Methicillin-sensitive Staphylococcus aureus (MSSA) cases were de-escalated to beta-lactams. The median time to optimal therapy was 3.7 hours for episodes of MSSA. Infectious Disease (ID) consultation significantly influenced antibiotic management, with …

Taking It To The Streets: A Comparative Case Study Of Urban Street Medicine Programs For The Unhoused Population, Dolly Dimple Harris

Theses and Dissertations

“Taking it to the Streets” originated from the 1960s social and political activism (Doohan & Mishori, 2019). The term reflects the 1990s movement when a Philadelphia physician decided that caring for the unhoused population was necessary and started street medicine. Street medicine is an alternative medical approach to formal healthcare intended to address unhoused individuals in their lived environment. In the street medicine model, healthcare providers offer medical support for the unhoused in alleyways, parks, under bridges, and encampments. The purpose of this comparative case study was to examine two street medicine programs’ administrative processes and how they provide healthcare …

Using Genetically Heterogenous Mice To Identify Regulators Of Immune Checkpoint Blockade Response, Justin Hackett

Wayne State University Dissertations

Immune Checkpoint Inhibitors (ICI) have dramatically improved patient outcomes in metastatic lung cancer, metastatic melanoma, subtypes of renal cancer and others. However, despite the clinical success, most patients still fail to have a durable response. Understanding what determines response and predicting who will respond to therapy is essential to improving patient outcomes. To investigate genetic underpinnings of ICI response we utilized F1 crosses of C57Bl/6 with Diversity Outbred mice (DOB6F1) and multiple Collaborative Cross (CC) strains to identify and validate (respectively) genetic loci that associated with response to ICI. The genomic data suggested that the lactation and immunomodulatory peptide prolactin …

Treatment Of Histoplasmosis With Posaconazole In The Setting Of A Severe Itraconazole Hypersensitivity Reaction: A Case Report, Kinsey M. Johannemann, Megan Z. Roberts, Samir Allos, Madeline Belk, Spencer H. Durham, Jonathan Edwards

UAB Huntsville Research Day - All Presentations

No abstract provided.

Psychosocial Correlates Of Hiv Prevention, Care, And Well-Being Among Older Women Aging With Hiv, Thi Vu

Yale Graduate School of Arts and Sciences Dissertations

Background: Approximately 54% of the nearly 1.1 million people living with diagnosed HIV in the United States are aged 50 and older. From 2015 to 2019, diagnoses among women ages 55 years and older increased by 7% while diagnoses among other age groups decreased. In 2019, women made up 19% of all HIV diagnoses. Despite advances in HIV science and education, there is still a dearth of research focused on the growing population of older women with HIV. Durvasula’s Contextualized Model for HIV/AIDS Care and Prevention for Older Women highlights that older women with HIV face different barriers to care, …

The Post-Alert Lexicon: A Multiphased Study To Develop Content For Post-Alert Messages, Jeannette Sutton, Hugh D. Walpole, Micki Olson, Lauren B. Cain, Savanah Olivas, Bruce Pollock, Nicholas Waugh

Emergency Preparedness, Homeland Security, and Cybersecurity Faculty Scholarship

Using a multi-phased, mixed methods approach, grounded in theory on alerts and warnings, the Post-Alert Lexicon serves as a companion to the Warning Lexicon to provide evidence-based guidance on how to construct a post-alert message for 45 hazards and missing person events. We draw from the results of quantitative content analyses of a census of post-alert messages issued as Wireless Emergency Alerts from 2012-2022, and public message testing experiments for three hazard types (wildfire, earthquake, and bomb threat), to find that a focus on hazard resolution and public action, rather than the commonly employed language of “all clear,” increases message …

Supports For Mental Well-Being Valued By Healthcare Workers: Qualitative Analysis Of Data From A Canadian Cohort Of Healthcare Workers During The Covid-19 Pandemic, Shannon Marie Ruzycki, Anil Adisesh, Quentin Durand-Moreau, France Labrèche, Tanis Zadunayski, Erica Stroud, Nicola Cherry

Études primaires

A prospective cohort of 4964 HCWs from four Canadian provinces was established early in the COVID-19 pandemic. Participants were invited to comment about workplace mental health supports at three time points. We performed a thematic content analysis of responses from 1738 participants using the Social Support Behaviour Code framework to categorize barriers to support as informational, tangible, emotional, social, or expressing esteem. Themes were synthesized into suggestions for healthcare organizations to prepare for future crises. Formal and informal peer support, workplace mental health supports, and one-on-one counseling were most often mentioned as valued. Analysis suggested that workplace social networks as …

Antibiotic Resistance: The Growing Threats And Potential Solutions, Olisaemeka Zikora Akunne, Blessing Nkechi Emmanuel, Umar Faruk Saidu, Ayobami Sunday Akinnawo, Nasiru Ademola Adeyemi, Livia Chinaza Egoh, Malami Aishatu Muhammad, Olusegun Ayo Ade-Adekunle, Deborah Ahuoyiza Peter, Anne Amina Freitas

Department of Biomedical and Translational Sciences Faculty Publications

Antibiotic resistance (AR) has become a critical global health crisis, threatening the efficacy of antibiotics and increasing healthcare costs, morbidity, and mortality. The One Health approach, which emphasizes the interconnectedness of human, animal, and environmental health, is increasingly recognized as an essential framework for addressing the complex drivers of AR. This review explores the mechanisms of resistance, such as genetic mutations, horizontal gene transfer, and biofilm formation, along with contributing factors such as the overuse of antibiotics in healthcare and agriculture. We assess both traditional and emerging strategies to combat AR, including antimicrobial stewardship, the development of new antibiotics, and …

The Effect Of Sars-Cov-2 On Bacterial Diversity And Abundance In Community Wastewater, Joshua Lambert

Graduate Theses, Dissertations, and Problem Reports (ETD)

Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) enters human respiratory cells through binding of its spike (S) protein to the ACE-2 receptor, which is highly expressed in lung cells, but is also found in over 150 other cell types encompassing major organs including GI enterocytes. SARS-CoV-2 causes gut dysbiosis in infected individuals and patients with COVID-19 and also coincides with lower alpha diversity of the individual’s gut microbiome. Certain gut microbiome-associated genera are lower in abundance in COVID-19 patients including Lachnospira, Prevetolla, Roseburia, Bifidobacterium, and Faecalibacterium while genera such as Bacteroides, Enterococcus and Proteobacteria are increased during a SARS-CoV-2 …

Cross-Cultural Data On Romantic Love And Mate Preferences From 117,293 Participants Across 175 Countries, Marta Kowal, Piotr Sorokowski, Biljana Gjoneska, Katarzyna Pisanski, Gerit Pfuhl, Leonardo Aguilar, Steve M.J. Janssen, Benjamin Gelbart, Patrícia Arriaga, Jan Antfolk, Katarina Zvončáková, Linda H. Lidborg, Jorge Contreras-Garduño, Mikhail V. Kozlov, Taciano L. Milfont, Marco A.C. Varella, Valerija Križanić, Mahmoud Boussena, Tina Kavčič, Diana Ribeiro Da Silva, Brahim Hamdaoui, Fatima Zahra Sahli, Karlijn Massar, Eliane Deschrijver, Tatsunori Ishii, Hakan Cetinkaya, Oksana Senyk, Farida Guemaz, Koen Ponnet, Yahya Don

School of Psychology

Psychological studies on close relationships have often overlooked cultural diversity, dynamic processes, and potentially universal principles that shape intimate partnerships. To address the limited generalizability of previous research and advance our understanding of romantic love experiences, mate preferences, and physical attractiveness, we conducted a large-scale cross-cultural survey study on these topics. A total of 404 researchers collected data in 45 languages from April to August 2021, involving 117,293 participants from 175 countries. Aside from standard demographic questions, the survey included valuable information on variables relevant to romantic relationships: intimate, passionate, and committed love within romantic relationships, physical-attractiveness enhancing behaviors, gender …

The Passing Of A Giant In Proteoglycan Research: Robert J. Linhardt (1953–2025), Renato V. Iozzo, Fuming Zhang, Paul L. Deangelis

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

No abstract provided.

Autolyzed Brewer's Yeast Enhances Growth And Intestinal Health In Early Life Stages Of Nile Tilapia (Oreochromis Niloticus L.), Sheu Odu-Onikosi, Taofik Momoh, Ben Eynon, Nicola Pontefract, Victor Kuri, Holger Kühlwein, Daniel Merrifield

School of Biological and Marine Sciences

The early life stages of fish are critical for determining the overall productivity and sustainability of aquaculture operations. This study investigated the effects of dietary autolyzed brewer's yeast (ABY) on the growth performance and intestinal health of Nile tilapia fry (Oreochromis niloticus). A 35-day feeding trial with 480 Nile tilapia fry across 12 experimental tanks tested the effects of diets supplemented with 1, 2, and 4 g/kg of ABY, with a control diet for comparison. The results indicated that the diet which had 1 g/kg ABY supplementation (ABY1) significantly enhanced the weight gain and specific growth rate (SGR) while reducing …

Week 96 Results Of Bictegravir/Emtricitabine/Tenofovir Alafenamide For Hiv Treatment In People With Substance Use Disorders, Joshua P. Havens, Sara Bares, Elizabeth Lyden, Nada A. Fadul, Susan Swindells

Journal Articles: Infectious Diseases

BACKGROUND: The BASE study (NCT03998176), a phase 4, 48-week (W), single-arm, prospective trial, revealed that the use of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in people with HIV and substance use disorders (PWH/SUD) was safe and effective without emergent antiretroviral resistance despite incomplete adherence. Here, we present the W96 results.

METHODS: A retrospective analysis of all participants enrolled in the BASE study was completed from W48 to W96. End points of interest at W96 included the proportion of participants with viral suppression (VS; HIV RNA < 50 copies/mL [c/mL]), incidence of protocol-defined virologic failure (PDVF; 2 consecutive ≥400 c/mL), safety, adherence (percentage of days covered [PDC]), retention in care, and prevalence of ongoing substance use.

RESULTS: All enrolled BASE participants (n = 43) were included in the W96 analysis. At W48, 21 participants …

Preferences And Feasibility Of Long-Acting Technologies For The Treatment Of Hepatitis C Virus: A Survey Of Patients In Diverse Low- And Middle-Income Countries, Renae Furl, Kimberly Scarsi, Harlan Sayles, Matt Anderson, Joelle Dountio Ofimboudem, Ethel D. Weld, Imam Waked, Asmaa Gomaa, Alzhraa Al-Khatib, Fatma Mohammed Elshobary, Hailemichael Desalegn, Henok Fisseha, Sunil Solomon, Shruti Mehta, Andrew Owen, Steve Rannard, David L. Thomas, Susan Swindells

Journal Articles: Infectious Diseases

Despite available curative treatments, global rates of hepatitis C virus (HCV) infection persist with significant burden in low- and middle-income countries (LMICs). Long-acting (LA) antiviral products are in development. This study explored the challenges and opportunities in LA-HCV treatment across three LMICs: Egypt, Ethiopia and India. The survey focused on understanding barriers and facilitators to treatment, with emphasis on LA treatment preferences. Four-hundred respondents completed a survey including demographics, HCV treatment history and preferences for injections, implants and microarray patches (MAPs) compared to pills. Overall, 78% of respondents were willing to receive injections, 43% were willing to receive implants and …

Efficacy And Safety Of 4-Month Rifapentine-Based Tuberculosis Treatments In Persons With Diabetes., Ekaterina V. Kurbatova, William C. Whitworth, Lakshmi Praveena Peddareddy, Patrick P. J. Phillips, Nigel A. Scott, Kia E. Bryant, Rodney Dawson, Sandra Wagner Cardoso, Wadzanai Samaneka, Melissa Engle, Ziyaad Waja, Erin Sizemore, Wendy Carr, Kelly E. Dooley, Radojka Savic, Susan Swindells, Richard E. Chaisson, Susan E. Dorman, Payam Nahid, Nhung V. Nguyen, Aids Clinical Trials Group A5349, Tuberculosis Trials Consortium Study 31

Journal Articles: Infectious Diseases

A previous study demonstrated noninferior efficacy of 4-month rifapentine/moxifloxacin regimen for tuberculosis (TB) treatment compared with the standard regimen. We explored results among study participants with diabetes. Among 2,516 randomized participants, 181 (7.2%) had diabetes. Of 166 participants with diabetes in the microbiologically eligible analysis group, 26.3% (15/57) had unfavorable outcomes in the control regimen, 13.8% (8/58) in the rifapentine/moxifloxacin regimen, and 29.4% (15/51) in the rifapentine regimen. The difference in proportion of unfavorable outcomes between the control and rifapentine/moxifloxacin arms in the microbiologically eligible analysis group was -12.5% (95% CI -27.0% to 1.9%); the difference between the control and …