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Asymmetric Synthesis Of The Hiv Protease Inhibitor Tmc-126 And An Anti-Malarial Agent Via A Titanium Tetrachloride Mediated Asymmetric Glycolate Aldol Addition Reaction. Redefining The Curtius Rearrangement Reaction Via Dehomologation Of Carboxylic Acids Bearing Alpha-Leaving Groups, Kweku Amaning Affram

Theses and Dissertations

Acquired Immune Deficiency Syndrome (AIDS) and malaria are two devastating infectious diseases caused by HIV and Plasmodium parasites. AIDS is caused by HIV-1 and HIV-2, transmitted through sexual contact, blood transfusions, needle sharing, and perinatal routes. Malaria, caused by plasmodium parasites through mosquito bites. Today, millions of people around the world have been infected with HIV and malaria and much research has been done to treat it. However, despite advancements in therapeutic options, these diseases remain a significant global health threat, particularly in developing countries due to the emergence of drug-resistant strains for both HIV and malaria complicating eradication efforts. …

The Role Of Sptbn1 Protein In Microglia Cells Actin Structure And Hiv-1 Infection, Rachel Pecka

Graduate Theses/Dissertations

Human immunodeficiency virus (HIV) directly attacks the host immune system by infecting and replicating in CD4-presenting immune cells. Like most viral pathogens, HIV utilizes cellular machinery to assist in viral entry, transport, and export. One of the components HIV is known to utilize for replication is the actin cytoskeleton. By directly binding to actin or actin-binding proteins, HIV can manipulate structural dynamics within the cell. The way HIV hijacks actin for replication post-viral fusion isn’t fully understood, especially during viral transport to the nucleus. A 2013 study conducted by Dai et al. found that lowering the expression of the cellular …

2025-2026 Course Catalog, University Of Montana--Missoula. Office Of The Registrar

University of Montana Course Catalogs, 1895-2024

An annual catalog of courses and course descriptions offered at the University of Montana.

3d Printed Microfluidic Platforms For Elisa-Based Diagnostics: Advancing Toward Point Of Care, Brandi Marie Binkley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Protein biomarker detection is a critical analytical method for quantifying proteins in biological samples. It is relevant not only in medical diagnostics and research but also numerous other fields such as environmental monitoring, pharmacology, food safety, and biotechnology. Sensitive detection at picogram-per-milliliter (pg/mL) levels is essential for diagnosing diseases, monitoring progression, and tailoring treatments, especially for low-abundance biomarkers like troponin, interleukin 6, carcinoembryonic antigen (CEA), activin A, and vascular endothelial growth factor (VEGF). Immunoassays, particularly enzyme-linked immunosorbent assays (ELISAs), are the gold standard for protein biomarker detection due to their high specificity and sensitivity. The development of point-of-care (POC) diagnostic …

Modernizing Immunization Data: The Key To Equitable Public Health In The U.S., Ahmad (Adra) S. Muntaha, Gulzar H. Shah

Eagles Talking About the Public’s Health

No abstract provided.

Men Take Care Of Each Other”: Evaluation Of A Community-Based Model For Pre-Exposure Prophylaxis Services Among Male Bar Patrons In Rural South Africa, Phoebe Chen

Yale Medicine Thesis Digital Library

Low engagement with HIV services persists among young men with harmful alcohol use in South Africa. We previously piloted a rural community-based HIV service delivery model to engage this key population. In the initial study, male nurses visited alcohol-serving venues to provide HIV testing and pre-exposure prophylaxis (PrEP) services. From November 1 to December 30, 2021, we conducted interviews with 17 of 34 male pilot participants to evaluate program barriers, facilitators, and suggestions. All Interviewees were satisfied with HIV testing and PrEP services. Participants overcame testing avoidance through peer influence and enhanced privacy. Barriers for PrEP initiation were stigma (PrEP …

The Development Of A Novel Large Language Model Method For Identification Of Incarceration History Via The Electronic Health Record And Evaluation Of Care Processes In The Emergency Department Setting, Thomas Huang

Yale Medicine Thesis Digital Library

Objective: Incarceration is a significant social driver of health and patients with a history of incarceration face systemic healthcare disparities, higher morbidity, mortality, and racialized health inequities. Incarceration status is largely invisible due to poor electronic health record (EHR) capture. In this thesis, we aim to develop, train, and validate a novel natural language processing technique to more effectively identify incarceration status in the EHR and apply this method in the emergency department setting to demonstrate proof of concept and elucidate care process disparities.Methods: The study population consisted of adult patients (≥ 18 y.o.) who presented to the emergency department …

Bovine Serum Albumin (Bsa) Impacts Morphology Of Fowler’S Toad (Anaxyrus Fowleri) Sperm During Short-Term Cold Storage, Jane A. Dill, Michelle K. Roy, Renato E. Naranjo, Andrew J. Kouba, Carrie K. Vance

Endeavors: Mississippi State Undergraduate Research Journal

Short-term cold storage of amphibian sperm is a valuable technique for overcoming challenges associated with asynchronous gamete release during breeding events or for transferring sperm between institutions for genetic management. Unfortunately, sperm longevity declines over time even when kept cool. Maintaining sperm form and function is critical to achieving the highest possible fertilization rates. Thus, cold storage of amphibian sperm would benefit from the addition of compounds that could extend their quality, improve fertilization and result in more offspring. One such compound is bovine serum albumin (BSA), which provides membrane stabilization, prevents lipid peroxidation of cells, protects against free radical …

Camellia Sinensis Phytochemical Profiling, Drug-Likeness, And Antibacterial Activity Against Gram-Positive And Gram-Negative Bacteria: In Vitro And In Silico Insights, Farouk Boudou, Amal Belakredar, Ahcene Keziz, Huda Alsaeedi, David Cornu, Mikhael Bechelany, Ahmed Barhoum

Research Outputs: 2025-Present

Background: Camellia sinensis extracts have a rich phytochemical profile and therapeutic properties. The plant contains bioactive compounds, such as catechins, flavonoids, and phenolic acids, which are associated with various health benefits, including antioxidant, anti-inflammatory, and anticancer activities. Aim: To investigate the bioactive potential of a Camellia sinensis extract, particularly its antibacterial activity against Gram-positive and Gram-negative bacteria and its drug-like properties. Method: Phenolic compounds in C. sinensis extract were identified and quantified using high-performance liquid chromatography (HPLC). Its antibacterial activity was assessed against both Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli). Drug-likeness, toxicity, and molecular properties …

Antimicrobial Activity Of Silver Nanoparticles Synthesized Using Thai Herbal Extracts, Charuwan Pradabsang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Synthesis of silver nanoparticles (SNP) using Thai herbal plants, namely Garcinia cowa Roxb. ex Choisy (S1), Boesenbergia rotunda (L.) Mansf. (S2), Curcuma mangga Valeton & Zijp (S3), Momordica charantia L. forma abbreviata (Ser.) W. J. de Wilde & Duyfjes (S4), Persicaria odorata (Lour.) Soják (S5), Litsea elliptica Blume (S6), Gnetum gnemon Linn. var. tenerum Markgr (S7), Phaleria macrocarpa (Scheff.) Boerl. (S8), Salacia chinensis Linn. (S9) and Brachypterum scandens (Roxb.) Miq. (S10), is considerably economical and safe. Plants and preparation methods can affect properties and bioactivity such as controlled temperature of SNP. This study aimed to assess the ability of aqueous …

Interaction Between Extreme Temperature Events And Air Pollution On Mortality In Thailand : A Nationwide Time Series Study, Phichet Khunthong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Climate change has increased the frequency and intensity of extreme temperature events (ETEs; heat and cold waves), concomitantly affecting PM2.5 fluctuation. However, limited research has investigated the interaction of ETEs and PM2.5 on mortality, particularly in tropical regions where the interaction could influence differently from cold countries. A two-stage time-series using distributed lag non-linear models was employed to estimate region-specific relative risks and 95% confidence intervals (RRs and 95% CIs) of ETEs and PM2.5 on daily cardiovascular and respiratory mortality. The relative excess risk due to interaction (RERI) was examined to quantify additive effects. Cold waves had the greatest effect …

A Guide To Falls In A Skilled Nursing Facility, Sarah Ghione

Doctoral Projects

Approximately one in four older adults experiences a fall each year in the United States (Centers for Disease Control and Prevention [CDC], 2024b; Kakara et al., 2023). Among those residing in nursing homes for either short-term rehabilitation or long-term care, the risk of falls is doubled (Acker & Janssen, 2017; Shao et al., 2023). The purpose of this doctoral capstone project was to develop an educational resource aimed at enhancing staff education and fall prevention efforts within a single nursing home, supporting the facility’s goal of reducing fall rates. Methods included a needs assessment, observational experiences, resource development, and the …

Examining Collaborative Healthcare For Substance Use Disorder: A Case Study Of Brigham And Women's Hospital Bridge Clinic, Megan Bidgood

Psychology Honors Papers

Individuals with substance use disorders (SUD) are clinically underserved due to increased health and psychiatric comorbidities, structural barriers to treatment, stigma, and insufficient resources. This suggests that there is a need for an accessible and culturally competent treatment model. Brigham and Women’s Hospital (BWH) Bridge Clinic is a multi-disciplinary, low threshold SUD treatment to promote collaborative healthcare and the transitioning of patients to longer-term care. The aim of the current study is to better understand personal accounts of patients and various clinical and non-clinical providers to optimize the BWH Bridge Clinic’s approach to treatment. Patients (N=5) and providers (N=6) participated …

Preventing Chemical And Biological Attacks: Enhanced Threats Requiring Enhanced Solutions, Alex Elliot Ottoni-Belval

Graduate Theses/Dissertations

Chemical weapons (CW) and biological weapons (BW) are becoming more dangerous for experts to employ and more accessible to amateurs. Despite CW and BW attacks throughout history that killed and maimed millions of people, the international community has failed to establish meaningful consequences to prevent them. Agreements such as the Chemical Weapons Convention and the Biological Weapons Convention vow to eliminate and reduce the effects of CWs and BWs but lack respected response precedents and capabilities. The limited and inconsistent enforcement has inadvertently allowed CWs and BWs to become plausible weapons, especially to gain asymmetric advantages, while modern developments exasperate …

Predicting Real Estate Prices Using Deep Learning Regression Models On Socio Spatial Data, Gentle Engworo

Graduate Theses/Dissertations

ABSTRACT

Cities keep their own kind of ledger. Every block, bus stop, corner store, and year that slips by leaves a small entry about what homes are worth. That ledger is what we call socio-spatial data: simple facts about what a home is (its age), where it sits (latitude/longitude), how easy it is to get around (distance to the nearest MRT station), what’s nearby (number of convenience stores), and when it sold (transaction date). This thesis asks a practical question in that everyday language: given these common clues, can we predict home prices more accurately and explain why? Using 414 …

The Role Of Host Factor Sptbn1 In Hiv-1 Capsid Uncoating In Human Microglial Cells, Callie Marie Fry

Graduate Theses/Dissertations

HIV-1 is the virus that causes acquired immunodeficiency syndrome (AIDS), and currently, there is no cure once an individual is infected. The development of new drugs targeting HIV-1 replication steps is essential for keeping viral loads low or undetectable to prevent further transmission. An attractive replication step for new drug targets is viral capsid uncoating, where the virus loses the protein structure encapsulating the genome. The exact mechanism of capsid uncoating is unknown; however, several host-factors may be involved including protein SPTBN1. Recent studies have shown a significant decrease in viral infectivity when SPTBN1 is knocked down, yet its role …

Nsu Health Professions Division 2024-2025 Course Catalog, Nova Southeastern University

HPD Course Catalogs

• Dr. Kiran C. Patel College of Osteopathic Medicine
• Barry and Judy Silverman College of Pharmacy
• College of Optometry
• Dr. Pallavi Patel College of Health Care Sciences
• College of Dental Medicine
• Ron and Kathy Assaf College of Nursing
• Dr. Kiran C. Patel College of Allopathic Medicine

Understanding The Impact Of The Care Connect Washington Program, Hannah Cohen-Cline, Dan Fish, Taylor Doren, Abby Bush

Articles, Abstracts, and Reports

No abstract provided.

Long-Term Antibacterial Efficacy Of Silver (I) Cyanoximates Against Streptococcus Mutans Ua159 Biofilm Growth, Tiffany A. Rojas

Honors Program Theses

Streptococcus mutans is the primary causative agent of dental caries due to its ability to form resilient multispecies biofilms. These biofilms promote acid production and degradation of the protective layers of the tooth, making biofilm formation a target for novel treatments. Silver(I) cyanoximates are of interest as alternatives to traditional antimicrobials and antibiotics due to the high UV and heat resistivity as well as poor solubility of the cyanoxime ligand paired with the well-established antimicrobial silver ion. Previous research has shown that silver(I) cyanoximates can effectively inhibit S. mutans biofilm formation after 24 hours in vitro. This study aimed to …

Social Determinants Of Health And Aging In Africa: Structural Inequality, Vulnerability, And The Future Of Care, Aremu Umor Lukman, Sunkanmi Folorunsho, Abdulrauf Olaitan Taofeeq

Department of Sociology: Faculty Publications

Population aging is accelerating across Africa yet remains underrepresented in research, policy, and public health planning. This review critically examines how social determinants shape aging experiences across the continent, focusing on health, care systems, and structural inequalities. While traditional African societies have historically valued older adults, modernization, migration, and economic hardship have eroded support systems, leaving many to face old age with limited resources. Older Africans, particularly women and rural residents, contend with lifelong disadvantages including low education, informal labor, poverty, and gendered caregiving roles that contribute to poor health and social vulnerability. Health systems remain poorly equipped to address …

How Decontextualised Risk Information Affects Clinicians’ Understanding Of Risk And Uncertainty In Primary Care Diagnosis: A Qualitative Study Of Clinical Vignettes, Alex Burns, Elizabeth Shephard, Raff Calitri, Adrian Mercer, Edmund Jack, Mark Tarrant, Sarah Dean

School of Psychology

Background: Decontextualised risk information (DRI) is any information pertaining to diagnosis, which is introduced into a clinical consultation, or a diagnostic thought process, without being requested by the clinician. It can be risk scores, computerised warnings, or laboratory tests or diagnostic imaging requests ordered by other clinicians. It is an increasing, and yet under-researched phenomena in UK primary care. Aim: To investigate how GPs integrate DRI into their clinical decision making and how might they communicate this to patients. Design & setting: Clinical vignettes of cases that involve DRI, designed to increase the diagnostic uncertainty of the case, were presented …

A Preliminary Study On The Role Of Personal History Of Infectious And Parasitic Diseases On Self-Reported Health Across Countries, Gerit Pfuhl, Filipe Prazeres, Marta Kowal, Toivo Aavik, Beatriz Abad-Villaverde, Reza Afhami, Leonardo Aguilar, Grace Akello, Laith Al-Shawaf, Jan Antfolk, Chiemezie S. Atama, Derya Atamturk Duyar, Roberto Baiocco, Sercan Balım, Carlota Batres, Yakhlef Belkacem, Théo Besson, Adam Bode, Merve Boğa, Jordane Boudesseul, Mahmoud Boussena, Hamdaoui Brahim, Nana Burduli, Ali R. Can, Hakan Cetinkaya, Antonio Chirumbolo, Dimitri Chubinidze, Clément Cornec, Bojana M. Dinić, Seda Dural

School of Psychology

Objectives: Infectious diseases are often associated with decline in quality of life. The aim of this study is to analyze the relationship between personal history of communicable, i.e., infectious and parasitic diseases and self-rated health. Study design: Secondary analysis of a large dataset multi-country observational study. Methods: We used a four-pronged analysis approach to investigate whether personal history of infectious and parasitic diseases is related to self-reported health, measured with a single item. Results: Three of the four analyses found a small positive effect on self-reported health among those reporting a history of pathogen exposure. The meta-analysis found no support …

Water Scarcity In The Bitterroot Valley, August W. Guenthner

Graduate Student Theses, Dissertations, & Professional Papers

Water scarcity in Montana’s Bitterroot Valley is an increasingly urgent issue, driven by the dual pressures of climate change and rapid population growth. Since 1970, the Bitterroot has been the fastest-growing region in the state, with much of this growth occurring in low-density rural subdivisions that rely on individual groundwater wells. Simultaneously, climate change has reduced snowpack levels, leading to diminished springtime recharge of surface water systems that are vital for both ecological and agricultural needs. For the Valley’s agricultural producers, adapting to decreasing water availability will be essential for sustaining their operations. This research project was designed to better …

Genetic Epidemiology Of Chronic Wasting Disease And Epizootic Hemorrhagic Disease In North Dakota Deer, Ethan S. Baker

Theses and Dissertations

Wildlife diseases have become a critical factor in the management of animal populations across the globe. Such diseases can compromise individual health, reduce population sizes, and disrupt ecosystem biodiversity. As a result, there can be a loss in recreational opportunities which, in turn, can cause economic losses for communities relying on these populations. Effective wildlife disease management not only requires the ability to respond to outbreaks but also the capacity to predict how diseases interact with populations and ecosystems. Due to the complexity of disease dynamics, a multidisciplinary approach is essential for gaining a comprehensive understanding of these systems. In …

Antimicrobial Susceptibility And Molecular Characterization Of Corynebacterium Pseudotuberculosis Isolates Recovered From Caseous Lymphadenitis In Sheep, Mohamed Bakr, Mahmoud E. Hashad, Islam Gomaa

Nanotechnology Research Centre

Corynebacterium pseudotuberculosis is a well-recognized etiological agent responsible for caseous lymphadenitis (CLA) and ulcerative lymphangitis (UL) in small and large ruminants, respectively. This pathogen is frequently associated with poor therapeutic outcomes in animals. In the present study, 30 bacterial isolates, recovered from 300 lymph node and pus samples (10%), were identified as Corynebacterium spp. Molecular confirmation using 16S rRNA and pld gene PCR verified 11 of these isolates as C. pseudotuberculosis, while one isolate was identified as C. jeikeium, a first record from sheep in Egypt. The isolates were subjected to antimicrobial susceptibility and genotyping using enterobacterial repetitive intergenic consensus-polymerase …

National Para Social Workers Handbook, Ministry Of Gender Labour And Social Development, Republic Of Uganda

Humanitarian Task Force

A resource guide for supporting para social workers in delivery of child protection and well-being services at community level in Uganda. This revised handbook integrates the Baobab project's sexual violence screening intervention.

Investigating Tlr-Mediated Cytokine Synergy In Macrophages, Erick Salvador Rocha

Yale Graduate School of Arts and Sciences Dissertations

Cytokine dysregulation during microbial infections can dangerously increase the severity of associated diseases. Non-additive responses to simultaneous activation of toll-like receptor (TLR) signaling pathways are one potential contributor. Here we explored mechanisms underlying the TLR2/MyD88 and TLR3/TRIF-mediated responses in macrophages for canonical pro-inflammatory and antiviral targets including TNF, IL-6, IL-12p40, IFN-β and CXCL10. We found that all targets exhibited characteristic levels of synergistic cytokine activation that varied with TLR-ligand concentration and exposure time. These trends were conserved when the TLR3-ligand polyI:C (PIC) was combined with either of the TLR2-mediated pathogens S. aureus or L. pneumophila. Using pharmacological inhibitors, genetic …

Deciphering Genetic Contributions To Antibiotic Persistence: Insights From Multi-Gene Knockout Studies, Elise K. Schweer

Electronic Theses and Dissertations

Antibiotic resistance is a critical global health challenge, complicating efforts to treat bacterial infections effectively. Antibiotic persistence plays a significant role in driving resistance. Persisters are a subpopulation of non-dividing bacterial cells that often evade lethal antibiotic treatment. Once antibiotics are removed, these cells "resurrect," resuming growth and may lead to relapsing infections. Notably, the progeny of persister cells exhibit a heightened tendency to acquire mutations or incorporate antibiotic resistance genes, further compounding the challenge of antibiotic resistance. In our recent study, we knocked out seven hypothetical genes and observed a significant reduction in persister levels. Compared to the wild …

Predictors Of Mental Health Services Use In Integrated Primary Care During Covid-19, Joseph D. Harrison

PCOM Psychology Dissertations

The purpose of this study was to identify the predisposing, need, and enabling factors that predict mental health services use before and during COVID-19 in an integrated primary care network in the Philadelphia metropolitan area. This retrospective observational study examined a sample of primary care patients from January 2018 to February 2020 (i.e., pre-COVID-19) and March 2020 to December 2022 (i.e., peri- COVID-19) using electronic health record data. Mental health services use was defined as the number of appointments attended by patients. A hierarchical regression was conducted to identify predictors of mental health services use by sequentially adding sociodemographic predisposing …

The Mule As Working Animal, Teacher, Soldier, Legend, Friend, Louis Medina

Eastern Sierra History Journal

Mules have played a significant role in the Eastern Sierra region of California, and far beyond. Louis Medina offers a warm appreciation of these legendary animals place in the region and its human community over time.