Digital Commons Network^™

Pgc-1Α Activation To Enhance Macrophage Immune Function In Mycobacterial Infections, Joel R. Frandsen, Zhihong Yuan, Brahmchetna Bedi, Zohra Prasla, Seoung-Ryoung Choi, Prabagaran Narayanasamy, Ruxana Sadikot

Journal Articles: Pathology and Microbiology

Nontuberculous Mycobacteria (NTM) are a heterogeneous group of environmental microorganisms with distinct human pathogenesis. Their incidence and prevalence are rising worldwide, due in part to elevated antimicrobial resistance which complicates treatment and potential successful outcomes. Although information exists on the clinical significance of NTMs, little is known about host immune response to infection. NTM infections alter macrophage mitochondrial capacity and decrease ATP production, efficient immune response, and bacterial clearance. Transcription factor peroxisome proliferator activated receptor (PPAR) γ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis, influencing metabolism, mitochondrial pathways, and antioxidant response. Mitochondrial transcription factor A (TFAM) is a …

Sash: Student Academic Showcase And Honors 2025, Roger Williams University

Student Academic Showcase and Honors

A celebration of scholarship and creative activities for undergraduate and graduate students

Evaluating The Effectiveness Of Teledermatology For Undeserved Populations During And Post-Covid-19, Jakob Gibbs, Sean Hanshaw

Theses, Dissertations and Capstones

Introduction: Teledermatology, a subset of telemedicine, has gained prominence as a means to increase access to dermatologic care while reducing costs and improving patient satisfaction. The swift expansion of teledermatology during the COVID-19 pandemic was driven by the necessity to limit physical contact and adapt to public health restrictions. This technological shift aimed to address longstanding disparities in dermatology access, especially in rural and underserved populations, and to respond to the rising demand for dermatologic services amid provider shortages.

Purpose of the Study: The purpose of this study was to analyze the effects that teledermatology following the COVID-19 pandemic had …

Vision 2025

Vision

No abstract provided.

Case Report Of Neurosyphilis, Caroline Finnerty, Elizabeth Diaz, Teena Mathew

North Texas Research Forum 2025

This is the case of a 29 year old female who initially presented with generalized joint aches noted to have neurosyphilis. Because of her delayed treatment, this case presents interesting findings that we classically no longer see in syphilis cases due to early detection and treatment. The case looks at the early symptoms as well as late symptoms if syphilis is left untreated. The patient was ultimately treated with IV penicillin with improvement of her symptoms.

Mass Sars-Cov-2 In A State Correctional System During The Pandemic, Charlotte Kim

Yale Medicine Thesis Digital Library

Mass screening has been shown to be more efficient in identifying infections in correctional facilities compared to symptom-based screening, but little is known about the impact of systematic mass screening on timely isolation of infectious cases over the course of the entire pandemic. Between March 2020 and May 2023, the Connecticut Department of Correction (CT DOC) performed a multifaceted SARS-CoV-2 testing strategy for its incarcerated population, which included RT-PCR for mass screening, as well as rapid antigen testing for contact tracing, symptom-based screening, and other miscellaneous reasons. Testing data reveals that mass screening identified 48% of all positive results, whereas …

Pancreatic Cancer Risk After Chronic Hepatitis C Virus Infection: A National, Population-Based Study, Rachel Levinson

Yale Medicine Thesis Digital Library

Studies of the association of hepatitis C virus (HCV), a known oncovirus, and pancreatic ductal adenocarcinoma (PDAC) are limited. We aimed to assess the relationship between chronic HCV infection, HCV genotype, and PDAC. In this retrospective cohort study, we identified individuals in the Veterans Health Administration from 2001 to 2021 with HCV testing. We categorized HCV status as those without HCV, those exposed (without chronic infection), or those with chronic infection. We evaluated incident PDAC by HCV status using Cox proportional hazards regression, adjusting for pertinent confounders. We further investigated the association between HCV genotype and risk of PDAC. Of …

Neurosurgical Praxis Guidelines During The Covid-19 Outbreak. Consensus-Based On Currently Available Literature., José Antonio Soriano Sánchez, Bárbara Nettel Rueda, José Alberto Israel Romero Rangel, Armando Alpizar Aguirre, Miguel Ángel Andrade-Ramos, Ulises García Dr., Diego Mendez Rosito, Jorge A. Santos, Sara Patricia Pérez Reyes, Julian Eduardo Soto Abraham, Jose E. Valerio Pascua, Marco Antonio Barajas Romero, Eduardo Díaz Juárez, Alma Griselda Ramírez Reyes, Maria Elena Gonzalez, Claudia Katiutska González Valdez, Félix Domínguez Cortinas, Noé Santiago Ramírez, Tenoch Herrada Pineda, Manuel Eduardo Soto García, Edgar Nathal Vera, Gustavo Melo Guzmán

Archives of Neurosurgery

INTRODUCTION: The World Health Organization recommended several strategies to contain the COVID-19 pandemic, including optimization of care for all patients, especially the seriously ill. Given the strain, the pandemic has posed on healthcare systems around the world, many neurosurgical associations have provided triage recommendations for patients to save resources for the pandemic. We aimed to provide practical recommendations based on specific illnesses requiring surgical procedures commonly performed by neurosurgeons on a life-threatening basis of patient illness. We consider this guideline will help neurosurgeons for the appropriate triage of patients on a daily-situation basis during this pandemic.

METHODS: The Mexican Society …

Healing Hands Are Clean Hands, Abigail Bruce Bsn, Rn, Katherine Benalcazar Adsn, Rn, Rosa Crespo Bsn, Rn, Dana Drywa Bsn, Rn, Maris Estevez Bsn, Rn, Erin Helge Bsn, Rn, Bilonda Kalemba Bsn, Rn, Kerryann Meggie Bsn, Rn, Amanda Silver Bsn, Rn, Jasmine Villafane Asn, Rn

Posters

• Our team identified the lack of hand hygiene throughout the department.
• Hand washing is an important part of infection prevention, and not washing hands properly or not at all, increases the rate of infections for our patients.
• Hand washing stations are out of reach or not available at all in certain areas of the emergency department, making it nearly impossible for optimal hand washing.
• Despite our efforts, hand hygiene habits can be improved throughout Bridgeport Hospital.

Characterization Of Legionella Pneumophila Effector Protein Ceg10, Emmanuella Ofoka

Masters Theses & Specialist Projects

Legionella pneumophila, the causative agent of Legionnaires' disease, utilizes a Type IV secretion system (T4SS) to transport effector proteins into host cells. This bacterium is said to have over 300 effector proteins. Among these, the Ceg10 effector protein had remained uncharacterized, despite evidence suggesting the importance of bacterial effector proteins in the host-pathogen interaction. This study aimed to perform a structural and functional characterization of Ceg10 through transcriptomic, bioinformatics, and molecular analyses. Transcriptomic profiling of HEK 293T cells expressing Ceg10 revealed significant differential gene expression, with approximately 20 upregulated genes, including leucine-rich repeat, as well as other downregulated genes. …

Dysphagia Turned Histoplasmosis: Histoplasmosis Manifesting As Oral Lesions In A Renal Transplant Patient, Alexis Nguyen, Sebastian Hinojosa, Trey Richardson, Levan Gakhokidze, Alissa Ice, Piera Sosa, Heidi Schaefer, Anthony Langone

Gulf Coast Division GME Research Day 2025

No abstract provided.

A Flea-Borne Mystery: Unraveling Murine Typhus In A Patient With Unexplained Encephalopathy, Jose Loayza Pintado, Jorge Aboytes Trevino, Ceasar Uribe

Gulf Coast Division GME Research Day 2025

No abstract provided.

When Skin Necrosis Mimics: Diagnostic And Therapeutic Challenges Of Calciphylaxis In A Ckd Patient With A Mechanical Heart Valve, Sienna Luk, Harshil Parekh, Vaishnavi Singh, Darshan Bhatty, Sathish Karmegam

North Texas Research Forum 2025

Calciphylaxis is a rare but serious condition characterized by the calcification and thrombosis of small blood vessels, predominantly affecting patients with end-stage renal disease (ESRD). Diagnosis can be challenging due to overlapping features with other vascular conditions, such as warfarin-induced skin necrosis (WSN). We present a case of a patient with ESRD and typical risk factors—peritoneal dialysis, hyperparathyroidism, and warfarin use—who exhibited classic skin findings suggestive of calciphylaxis. However, two skin biopsies were inconclusive. Management involved addressing the patient's calciphylaxis risk factors, optimizing dialysis, and initiating sodium thiosulfate therapy. The case was further complicated by the need to replace warfarin, …

Effect Of Praziquantel Treatment On The Nutritional Status Of Children Infected With Schistosoma Haematobium, Louis Fok, Hongying Dai, David Brett-Major, Abebe Animut, Berhanu Erko, John Linville, Yohannes Negash, Abraham Degarege

Journal Articles: Epidemiology

This quasi-experimental trial examined the relationship between Schistosoma haematobium infection and nutritional status, and the impact of single dose praziquantel (PZQ) therapy on undernutrition. A total of 353 children were examined, 112 of which were infected with S. haematobium and treated with PZQ. Children's heights, weights, and mid-upper arm circumferences (MUAC) were measured at baseline and one month post-treatment. Infected children had significantly smaller mean BMI-for-age z-scores (BAZ) (-1.16 vs. 0.11, p < 0.01) and weight-for-age z-scores (WAZ) (-0.61 vs. -0.31, p = 0.03) than the uninfected ones at baseline. S. haematobium infection was associated with underweight (adjusted OR: 1.76, 95% CI: 1.63-1.90). One month after treatment, BAZ, WAZ, …

Challenges In Public Health: The Diagnosis And Treatment Of Crusted Scabies, Marshall Hall, Alyssa Forsyth, Wenquin Du, Michael Carletti, Stephen Weis

North Texas Research Forum 2025

Introduction: Common scabies is a parasitic dermatologic condition that often presents as an extremely pruritic rash. A rare and highly contagious variant of common scabies is crusted scabies, formerly known as Norwegian scabies. While infection with common scabies typically involves 10 to 20 mites, individuals with crusted scabies are burdened with thousands to millions of mites. Crusted scabies is characterized clinically by hyperkeratotic papules and plaques, most commonly on the palms and soles. Due to the variety of presentations seen in scabies, it can be difficult to diagnose. Case presentations: We present 4 cases of crusted scabies. An 89-year-old male …

Necrotizing Alternaria Pneumonia In An Immunocompetent Male, Joel Mathews, Jose Aguilar-Martinez, Sean Sojdie, Zain Tariq, Tamer Hudali

North Texas Research Forum 2025

Abstract: Alternaria species is a rare cause of invasive fungal pneumonia, typically described as an opportunistic pathogen, usually seen in immunocompromised patients producing virulent forms of sinus, cutaneous, and ocular infections. Alternaria species sparingly affect immunocompetent individuals and are often managed without any medical interventions. We present a case of invasive fungal necrotizing pneumonia caused by Alternaria alternata species in an immunocompetent 28-year-old male with only a past medical history of well-controlled asthma managed with an as-needed albuterol inhaler. His complaints included worsening foul-smelling productive cough with yellow-dark brown sputum along with subjective fevers, chills, chest pain, and dyspnea for …

Atypical Stroke-Like Presentation In A Patient With Mucormycosis, Joseph Crutison, Yasser El-Daour, Dominique Pean

Gulf Coast Division GME Research Day 2025

No abstract provided.

Fluoridation Facts, American Dental Association

Fluoridation Facts

Fluoridation Facts is the ADA's premier resource on fluoridation, answering frequently asked questions about community water fluoridation and the latest scientific research. The book assists policy makers and the general public in making informed decisions about fluoridation. With an easy-to-use question-and-answer format that draws on more than 400 references, the book answers queries about fluoridation's effectiveness, safety, practice and cost-effectiveness. 114 pages.

“Science Belongs Everywhere”: Outlooks On Post-Secondary Stem Education For Correctional Centers In Virginia, Shelita R. Augustus

Division of Strategic Enrollment Management and Student Success Publications

Virginia has an incarceration rate of 679 per 100,000 residents, the highest among independent democratic nations. This scoping review examines perspectives on post-secondary STEM education to promote STEM education within Virginia's correctional facilities, assesses programs to improve rehabilitation, reduce recidivism, and address systemic inequalities by developing the scientific potential of incarcerated individuals. The review finds that while STEM education in correctional facilities faces limitations, its potential benefits are being realized nationwide. Virginia has made strides through initiatives like House Bill 2158, which aims to expand higher education access for incarcerated individuals. Examples such as the programs at J. Sargeant Reynolds …

Everyone Wore Masks: Winter Baseball During The Flu Pandemic Of 1918–1919, Revised, Mark E. Eberle

Monographs

Efforts to control the influenza pandemic of 1918–1919 were in the hands of local officials, creating a mosaic of regulations. Among the aspects of society affected by these regulations were organized sports, which attracted large groups of people that could contribute to the spread of the disease. Infection rates were highest during the cooler months, so baseball was largely unaffected. However, southern California had an active winter baseball season that attracted major league players, who earned money by playing for teams such as the Pasadena Merchants. Pasadena and the Standard-Murphy team from the oil field region near Whittier were in …

The Supreme Court During Covid-19: Keeping Its Head When Those About It Were Losing Theirs, Timothy C. Macdonnell

Scholarly Articles

Alexander Hamilton's Federalist No. 78 suggests that one of the reasons for a life-tenured judiciary whose pay cannot be altered is because "judges may be an essential safeguard against the effects of occasional ill humours in the society." Our Nation's history is replete with instances of ill humor leading to violations of constitutional rights. Wars, epidemics, natural disasters, civil unrest, and economic crises all demand governments to act and act swiftly. But courts, and particularly the United States Supreme Court, are necessary to check governments when they go too far in contending with an emergency.

Historically the country's courts have …

Review Of Protein-Protein Interaction Prediction Using Artificial Intelligence, Brian Ng

Seton Hall Biochemistry II Annals of Student Reviews

No abstract provided.

Optimization Of Wash-Dr And Rwanda Ceramic Hwts Systems, Hamza Zeini

Honors Program Theses

Access to safe drinking water remains a global challenge, affecting over 2 billion people. Fecal coliform contamination poses serious health risks, particularly in developing regions like the Dominican Republic and Rwanda. Rollins College professors have implemented Field Studies to support water filter distribution in these areas. This study evaluates the optimization of Household Water Treatment and Safe Storage (HWTS) systems used in the WASH-DR and Rwanda-Rural Education Field Studies, focusing on Dr. Bernal’s chlorination and filtration system and Rwanda’s ceramic filters. A key innovation is the integration of the MadiDrop+, a silver-impregnated ceramic tablet that releases antimicrobial silver ions, as …

Humanities In The Biology Classroom: Cultivating Their Connection To Spanish-Speaking Students, Betzy Lopez

Theses & ETDs

With the increase in the Hispanic population, there has also been an increase in Hispanic students enrolled in school. Within this population of enrolled Hispanic students, some are considered English Language Learners (ELLs). Hispanic and ELL students in high school in Manatee County, Florida, United States, have low results in their science assessments, including the Biology 1 End of Course exams required to take to graduate high school in Florida. To help students engage and connect during their biology courses, this thesis provides four lesson plans with grading rubrics about infectious diseases and the immune system. In these lesson plans, …

Medieval Solutions To Modern Pandemics: A Comparative Analysis Of Social Reactions To The Black Death And Covid-19 Pandemics, Ciara Mcilvenny

Theses & ETDs

This thesis explores the various social reactions to pandemics, particularly the Black Death and COVID-19. During the Black Death, people struggled with displacement, sickness, and death due to the pestilence, causing them to turn to their scientific and religious institutions for explanations. 673 years later, the world was struck by the COVID-19 pandemic, resulting in the same consequences. The social reactions to the most recent COVID-19 pandemic are eerily similar to those recorded during the Black Death, revealing the consistency in human nature when responding and reacting to pandemics.

Species-Specific Discrimination Of Bacterial Biofilms Using A Ratiometric Fluorescence Sensor Array And Machine Learning, Ritika Gupta, Aayushi Laliwala, Elena Muldiiarova, Kenneth W. Bayles, Denis Svechkarev, Marat Sadykov, Aaron M. Mohs

Journal Articles: Pathology and Microbiology

Biofilms are intricate bacterial communities encased in a self-produced extracellular matrix (ECM) of DNA, lipids, proteins, and polysaccharides. The diverse ECM composition across bacterial species significantly influences the progression of biofilm-associated infections, making precise identification crucial for effective treatment. Traditional methods such as biochemical assays, MALDI-TOF mass spectrometry, DNA sequencing and culturing provide valuable insights but have notable drawbacks, including time-consuming procedures, high costs, and the need for specialized equipment and trained personnel. These limitations hinder the rapid and widespread adoption of biofilm identification in clinical settings, underscoring the need for more streamlined, accurate, and accessible methods. In this study, …

Efficacy Of Low-Level Laser Therapy For Osteoarthritis Of The Knee, Emily Drummond

The PA Department Journal of Medical Science

Introduction: Osteoarthritis (OA) is a disease associated with numerous effects on quality of life (QoL) and activities of daily living (ADLs). In recent years, low-level laser therapy (LLLT) has been evaluated as a symptom management option for KOA due to its non-invasive mechanistic properties. The purpose of this paper is to assess the efficacy of LLLT as a modality of treatment to help reduce mild to moderate symptoms associated with KOA.

Methods: A search via PubMed database was made using the keywords “LLLT” AND “osteoarthritis” AND “knee” with additional specifiers resulting in 10 articles for review. Four articles were chosen …

Antibiotics Vs Appendectomy In Acute Uncomplicated Appendicitis, Elizabeth Wilson

The PA Department Journal of Medical Science

Introduction: Acute appendicitis is a common cause of the acute abdomen, and the current standard of care is surgical removal of the appendix. The purpose of this review is to compare the long-term efficacy of antibiotics in the treatment of acute uncomplicated appendicitis.

Methods: PubMed was searched using the key terms “anti-bacterial agents” AND “appendicitis” AND “appendectomy”. Operators and filters narrowed results to four relevant articles for review.

Results: Of the four articles, 3 were meta-analyses of the same RCTs comparing the efficacy of antibiotic therapy to appendectomies. The fourth reviewed 12 RCTs comparing antibiotic therapy to appendectomies.

Discussion: …

A Clinical Review Of The Efficacy Of Masks In Preventing Spread Of Sars-Cov-2, Harrison Nobles

The PA Department Journal of Medical Science

Introduction:

The COVID-19 pandemic, caused by SARS-CoV-2, has sparked debate over the effectiveness of masks in reducing viral transmission. This clinical review aims to evaluate the efficacy of cloth masks, medical masks, and N95 respirators in preventing COVID-19 transmission.

Methods:

A literature search was conducted on PubMed for articles published between January 2020 and August 2024. Out of 27 screened articles, 5 met the inclusion criteria, focusing on mask efficacy in preventing SARS-CoV-2 transmission.

Results:

Of the 5 studies included, three were systemic reviews, one was a metanalysis and one was a systemic review and meta-analysis. The largest …

Gattonrx Magazine - 2025, Bill Gatton College Of Pharmacy, East Tennessee State University

GattonRX Magazine

No abstract provided.