Digital Commons Network^™

Ethical Considerations For Sharing Aggregate Results From Pragmatic Clinical Trials, Stephanie R Morain, Abigail Brickler, Joseph Ali, Patricia Pearl O'Rourke, Kayte Spector-Bagdady, Benjamin Wilfond, Vasiliki Rahimzadeh, Caleigh Propes, Kayla Mehl, David Wendler

Center for Medical Ethics and Health Policy Staff Publications

A growing literature has explored the ethical obligations and current practices related to sharing aggregate results with research participants. However, no prior work has examined these issues in the context of pragmatic clinical trials. Several characteristics of pragmatic clinical trials may complicate both the ethics and the logistics of sharing aggregate results. Among these characteristics include that pragmatic clinical trials may affect the rights, welfare, and interests of not only patient-subjects but also clinicians, meaning that results may be owed to a broader range of groups than typically considered in other research contexts. In addition, some pragmatic clinical trials are …

Insights Into Protection Against Mycobacterium Tuberculosis Infection: Time To Officially Confirm Another Phenotype?, Todia P Setiabudiawan, Philip C Hill, Andrew R Dinardo, Reinout Van Crevel

Faculty, Staff and Students Publications

Immune correlates of protection against infection with Mycobacterium tuberculosis (Mtb) remain elusive. In this issue of the JCI, Dallmann-Sauer and authors demonstrate that lack of tuberculin skin test (TST) and interferon γ release assay (IGRA) conversion among people with HIV despite years-long Mtb exposure is associated with alveolar lymphocytosis, including specific poly-cytotoxic T cells, and M1-type alveolar macrophages with a stronger ex vivo response to the pathogen. Studies in these rare individuals, termed "TB resisters" and in tuberculosis household contacts who are repeatedly IGRA negative in the months after a specific exposure event (known as "early clearers") help elucidate manipulatable …

Statin Use Is Associated With Protection Against Acute Cholangitis In Patients With Primary Sclerosing Cholangitis: A Multicenter Retrospective Cohort Study, Chiraag Kulkarni, George Cholankeril, Touran Fardeen, Joseph Rathkey, Samir Khan, Soumya Murag, Robert Lerrigo, Ahmad Kamal, Ajitha Mannalithara, Prasun Jalal, Aijaz Ahmed, John Vierling, Aparna Goel, Sidhartha R Sinha

Faculty, Staff and Students Publications

Introduction: Patients with primary sclerosing cholangitis (PSC) are at increased risk of acute cholangitis. The epidemiological risks of cholangitis are poorly studied despite the high morbidity associated with this infection. The aim of this study was to understand the impact of statins on acute cholangitis in PSC.

Methods: This multicenter, retrospective cohort study assessed data from 294 patients with PSC at Stanford Medical Center, Baylor Medical Center, and Valley Medical Center. Clinical factors associated with the development of cholangitis were identified using multivariable Cox regression.

Results: The patients were predominantly male (68.7%) with a median age at enrollment of 48 …

Postvaccination Immunogenicity Among Pediatric Solid Organ Transplant Recipients, Amy G Feldman, Brenda L Beaty, Jose A Ferrolino, Gabriela Maron, Saira A Ali, Leandra Bitterfeld, Adam Blatt, Mary Alice Boulware, Kathleen M Campbell, Emily Carr, Benhur Cetin, Shelley Chapman, Yeh-Chung Chang, Ryan Cunningham, Ronald H Dallas, Keerti L Dantuluri, Bryanna N Domenick, Noelle H Ebel, Scott Elisofon, Rima Fawaz, Marc Foca, Hayley A Gans, Vani V Gopalareddy, Nitika A Gupta, Katherine Harmann, Jessica Hollenbeck, Anna R Huppler, Catalina Jaramillo, Nagraj Kasi, Nanda Kerkar, Stacee Lerret, Steven J Lobritto, M James Lopez, Alisha Mavis, Sonia Mehra, Sindhu Mohandas, Flor M Munoz, Krupa R Mysore, Nadia Ovchinsky, Kerrigan Perkins, Stacy Postma, Lauren Pratscher, Elizabeth B Rand, Regina K Rowe, Daniel Ruderfer, Danielle Schultz, Katherine Sear, Megan L Sell, Tanvi S Sharma, Janis Stoll, Jerry Turner, Kristen G Valencia Deray, Dominique Villarin, Carly Weaver, Phoebe Wood, Olivia Woodford-Berry, George Yanni, Lara A Danziger-Isakov

Faculty, Staff and Students Publications

This cohort study assesses the protection provided by live attenuated viral vaccines among a pediatric population of solid organ transplant recipients 1 year after vaccination.

Variability In Treatment Of Utis In Children With Genitourinary Anomalies In Children's Hospitals, Catherine S Forster, Alexis C Wood, Stephanie Davis-Rodriguez, Sanyukta Desai, Pearl W Chang, Michael J Tchou, John M Morrison, Rana F Hamdy, Vijaya Vemulakonda, Patrick W Brady, Cynthia Abou Zeid, Sowdhamini S Wallace, Uti In Children With Cakut Study Group

Faculty, Staff and Students Publications

Objective: In children with urinary tract anomalies, febrile urinary tract infections (UTIs) are associated with increased risks of sepsis, hospitalization, and kidney injury. However, the best treatment strategies are unknown. We aimed to describe antibiotic treatment practices and outcomes for UTIs in children with urinary tract anomalies and evaluate whether variability in UTI treatment exists between hospitals.

Methods: We conducted a multicenter retrospective cohort study of children seen in emergency departments (EDs) in 6 free-standing US children's hospitals from January 1, 2017, through December 31, 2018. We included children aged 0-17 years with an anatomic or functional urinary tract anomaly …

Inborn Errors Of Immunity Reveal Molecular Requirements For Generation And Maintenance Of Human Cd4+ Il-9-Expressing Cells, Geetha Rao, Corinne D Mack, Tina Nguyen, Natalie Wong, Kathryn Payne, Lisa Worley, Paul E Gray, Melanie Wong, Peter Hsu, Michael O Stormon, Kahn Preece, Daniel Suan, Michael O'Sullivan, Annaliesse K Blincoe, Jan Sinclair, Satoshi Okada, Sophie Hambleton, Peter D Arkwright, Kaan Boztug, Polina Stepensky, Megan A Cooper, Liliana Bezrodnik, Kari C Nadeau, Hassan Abolhassani, Roshini S Abraham, Mikko R J Seppänen, Vivien Béziat, Jacinta Bustamante, Lisa R Forbes Satter, Jennifer W Leiding, Isabelle Meyts, Emmanuelle Jouanguy, Stéphanie Boisson-Dupuis, Gulbu Uzel, Anne Puel, Jean-Laurent Casanova, Stuart G Tangye, Cindy S Ma

Faculty, Staff and Students Publications

Background: CD4+ T cells play essential roles in adaptive immunity. Distinct CD4+ T-cell subsets-TH1, TH2, TH17, TH22, T follicular helper, and regulatory T cells-have been identified, and their contributions to host defense and immune regulation are increasingly well defined. IL-9-producing TH9 cells were first described in 2008 and appear to play both protective and pathogenic roles in human immunity. However, key requirements for generating human TH9 cells remain incompletely defined.

Objective: We sought to define signaling pathways that regulate IL-9 production by human CD4+ T cells.

Methods: Human naive and memory CD4+ T cells were cultured under different conditions, and …

Rapid Diagnostic Sequencing Of Stool Dna Using Targeted Nanopore Sequencing In Patients With A Pulmonary Tuberculosis Diagnosis, Tara Ness, Nontobeko Maphalala, Wethusonkhe Khumalo, Doctor Sibandze, Abigail Seeger, Maia Madison, Anca Vasiliu, Durbin Mulengwa, Clement Gascua, Mangaliso Ziyane, Sindisiwe Dlamini, Gugu Maphalala, Eric Bortz, Alexander Kay, Christoph Lange, Viola Dreyer, Tanja Niemann, Stefan Niemann, Andrew Dinardo, Anna Mandalakas, Stool4tb Global Partnership

Faculty, Staff and Students Publications

Background: Approximately 1.25 million individuals died of tuberculosis in 2023, in part due to ineffective treatment. In patients with paucibacillary tuberculosis, microbiologic confirmation and drug resistance testing via respiratory specimens is challenging; hence, stool samples are increasingly used for microbiologic confirmation. Targeted next-generation sequencing (tNGS) of stool DNA may improve detection of drug-resistant (DR) tuberculosis, helping patients receive appropriate treatments.

Methods: We assessed the ability of a nanopore tNGS approach using stool to detect drug resistance in a prospective, nested cohort of consecutive participants in Eswatini with pulmonary tuberculosis confirmed via sputum culture or sputum GeneXpert Ultra from 2020 to …

Who And Its Enduring Commitment To Global Pediatrics, Peter J Hotez

Faculty, Staff and Students Publications

No abstract provided.

Postnatal Zika And Dengue Infection And Their Effects On Neurodevelopment Among Children Living In Rural Guatemala, Edwin J Asturias, Amy K Connery, Daniel Olson, Molly M Lamb, Alejandra Paniagua-Avila, Evan J Anderson, Chris Focht, Alison M Colbert, Muktha Natrajan, Jesse J Waggoner, Erin Scherer, D Mirella Calvimontes, Guillermo A Bolaños, Desirée Bauer, Paola Arroyave, Sara Hernández, Maria A Martinez, Aida V Ralda, Neudy Rojop, Edgar E Barrios, Andrea Chacon, Walla Dempsey, Kay M Tomashek, Wendy A Keitel, Hana M El Sahly, Flor M Muñoz

Faculty, Staff and Students Publications

Background: Prenatal Zika virus (ZIKV) infection leads to microcephaly and adverse neurodevelopment. The effects of postnatal ZIKV infection on the developing brain are unknown. We assessed the neurodevelopmental outcomes of children exposed postnatally during the ZIKV epidemic.

Methods: A prospective study enrolled infants 0-3 months of age and their mothers, and children 1.5-3.5 years of age in rural Guatemala from 2017 and were followed for 12 months until 2019. Neurodevelopment was evaluated using the Mullen Scales of Early Learning (MSEL). ZIKV and dengue virus (DENV) infections were identified by polymerase chain reaction (PCR) using active surveillance. Serological analyses, stratified by …

Examining The Impact Of Feature Selection Techniques On Machine And Deep Learning Models For The Prediction Of Covid 19, Hafiza Zoya Mojahid, Jasni Mohamad Zain, Marina Yusoff, Abdul Basit, Abdul Kadir Jumaat, Mushtaq Ali

Malaysian Journal of Computing (MJoC)

Feature selection is a vital preprocessing step for identifying the most informative features in complex datasets, enhancing the efficiency and accuracy of machine learning models. Its applications extend across various domains, including big data analytics, finance, chemometrics, medical diagnostics, biological research, intrusion detection systems, and renewable energy solutions. In medical contexts, feature selection serves a dual purpose: it reduces dimensionality while simultaneously improving the comprehension of disease etiology. This study delves into key variable selection methods—specifically Recursive Feature Elimination (RFE), Principal Component Analysis (PCA) and Least Absolute Shrinkage and Selection Operator (LASSO). We evaluate the interaction of these methods with …

Enhancing User Authentication Through The Implementation Of The Forestpa Algorithm For Smart Healthcare Systems, Nurul Syafiqah Zaidi, Al-Fahim Mubarak Ali, Ahmad Firdaus, Adamu Abubakar Ibrahim, Adamu Abubakar Ibrahim, Mohd Faizal Ab Razak

Mesopotamian Journal of CyberSecurity

The machine learning-based authentication model for smart healthcare systems represents a crucial step in addressing the needs of an ever-evolving healthcare industry. The need to protect sensitive patient data, ensure regulatory compliance, and reduce medical errors, especially in the context of telemedicine and remote monitoring, underscores the importance of such systems. Traditional authentication methods frequently lack sufficient security, resulting in potential breaches. Relying solely on usernames and passwords, without supplementary authentication measures, exposes systems to advanced security attacks. As it involves patients’ health and human lives, it is important to provide additional authentication, fast machine learning-based authentication models and high …

Antibody Responses In Klebsiella Pneumoniae Bloodstream Infection: A Prospective Cohort Study, Wontae Hwang, Paeton L Wantuch, David A Rosen, Et Al.

2020-Current year OA Pubs

BACKGROUND: Klebsiella pneumoniae is a leading cause of infection-related deaths globally, yet little is known about human antibody responses to invasive K pneumoniae. We sought to determine whether the O-specific polysaccharide antigen is immunogenic in humans with K pneumoniae bloodstream infection. We also sought to define the cross-reactivity of human antibody responses among structurally related K pneumoniae O-specific polysaccharide subtypes and to assess the effect of capsule production on O-specific polysaccharide-targeted antibody binding and function.

METHODS: In this prospective cohort study, we compared plasma antibody responses to O-specific polysaccharide in a cohort of consecutively enrolled patients with K pneumoniae bloodstream …

Safety And Efficacy Of Fecal Microbiota, Live-Jslm, In Preventing Recurrent Clostridioides Difficile Infection In Participants Who Were Mildly To Moderately Immunocompromised In The Phase 3 Punch Cd3-Ols Study, Carolyn D Alonso, Glenn S Tillotson, Monique R Bidell, Beth Guthmueller, Frederikke Hoeyer, Monika Fischer, Erik R Dubberke

2020-Current year OA Pubs

BACKGROUND: Fecal microbiota, live-jslm (RBL; Rebyota), is the first Food and Drug Administration-approved, single-dose, microbiota-based live biotherapeutic to prevent recurrent

METHODS: Participants with rCDI who had immunocompromising conditions and/or were taking immunosuppressive medications were included. Treatment-emergent adverse events (TEAEs) were collected for up to 6 months following RBL administration. Efficacy outcomes included treatment success at 8 weeks and sustained clinical response at 6 months.

RESULTS: Overall, 793 participants were enrolled in PUNCH CD3-OLS and 697 received RBL; 141 were included in the immunocompromised subgroup. TEAEs within 8 weeks were reported by 44.7% and 48.0% of participants in the immunocompromised and …

Patient- And Community-Level Characteristics Associated With Respiratory Syncytial Virus Vaccination, Diya Surie, Jennie H Kwon, Et Al.

2020-Current year OA Pubs

IMPORTANCE: In 2023, the first respiratory syncytial virus (RSV) vaccines were recommended for US adults 60 years or older, but few data are available about which patients were most likely to receive vaccine to inform future RSV vaccine outreach efforts.

OBJECTIVE: To assess patient- and community-level characteristics associated with RSV vaccine receipt and patient knowledge and attitudes related to RSV disease and RSV vaccines.

DESIGN, SETTING, AND PARTICIPANTS: During the first season of RSV vaccine use from October 1, 2023, to April 30, 2024, adults 60 years or older hospitalized with RSV-negative acute respiratory illness were enrolled in this cross-sectional …

Hospital-Onset Bacteremia In The Neonatal Intensive Care Unit: Strategies For Risk Adjustment, Erica C Prochaska, Shaoming Xiao, Elizabeth Colantuoni, Nora Elhaissouni, Reese H Clark, Julia Johnson, Sagori Mukhopadhyay, Ibukunoluwa C Kalu, Danielle M Zerr, Patrick J Reich, Jessica Roberts, Dustin D Flannery, Aaron M Milstone, Cdc Prevention Epicenters Program

2020-Current year OA Pubs

OBJECTIVE: To quantify the impact of patient- and unit-level risk adjustment on infant hospital-onset bacteremia (HOB) standardized infection ratio (SIR) ranking.

DESIGN: A retrospective, multicenter cohort study.

SETTING AND PARTICIPANTS: Infants admitted to 284 neonatal intensive care units (NICUs) in the United States between 2016 and 2021.

METHODS: Expected HOB rates and SIRs were calculated using four adjustment strategies: birthweight (model 1), birthweight and postnatal age (model 2), birthweight and NICU complexity (model 3), and birthweight, postnatal age, and NICU complexity (model 4). Sites were ranked according to the unadjusted HOB rate, and these rankings were compared to rankings based …

Introduction Of Clinical Pastoral Education In Ukraine: The Experience Of The Volyn Orthodox Theological Academy, Vladyslav Fulmes, Volodymyr Vakin, Oleksandr Khoroshko

Occasional Papers on Religion in Eastern Europe

Medical chaplaincy is an important component in many countries, as it helps to ensure a holistic approach to treatment, taking into account the spiritual needs of patients. The relevance of this direction was due to the invasion of russian troops on the territory of Ukraine back in 2014, and in the conditions of a full-scale war in Ukraine, the role of medical chaplaincy has increased significantly. This article reveals the experience of the Volyn Orthodox Theological Academy (Lutsk, Ukraine) in training medical chaplains, which was the first in Ukraine, responding to social challenges, in particular health care institutions, to develop …

Faculty Senate Meeting Agenda And Minutes, March 31, 2025

Faculty Senate Minutes and Agendas

Agenda and minutes from the Wright State University Faculty Senate Meeting held on, March 31, 2025.

Vaccination As A Protective Factor Against Hospitalization For Sars-Cov-2 Infections: An Observational Study Using Surveillance Data, Chandrayani Simanjorang, Kristin Mutiara Tarigan, Diva Anita Churiana Sudrajat, Rana Zahra Raniyah Wangsawinangun, Asy Syifa Anwari Zahra

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Death due to SARS-CoV-2 generally occurs in patients requiring hospital care (hospitalization). However, it is still unclear whether vaccination acts as a protective factor against hospitalization in SARS-CoV-2 patients in Indonesia. This study examines the association between vaccination and hospitalization among SARS-CoV-2 patients. It employs a quantitative, cross-sectional design using secondary data from SARS-CoV-2 surveillance records at the Jakarta Health Agency (January–August 2021). Findings show that patients who received the 1st vaccine dose had a 0.34 times lower risk of hospitalization compared to unvaccinated individuals (aPOR=0.34; 95% CI=0.31–0.38). Those who received the 2nd dose had an even lower risk (aPOR=0.16; …

Dampak Tradisi Pemberian Nasi Papahan Terhadap Kesehatan Bayi Usia 6-24 Bulan: Literature Review, Sakinah Hadirama, Tri Krianto Karjoso

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Praktik pemberian nasi papahan seringkali dianggap sebagai bentuk kasih sayang antara ibu kepada bayi dan bertujuan untuk memudahkan bayi dalam mengonsumsi makanan, padahal hal tersebut tidak baik bagi kesehatan karena dapat menjadi media penularan penyakit apabila ibu menderita penyakit menular tertentu sehingga mengakibatkan gangguan kesehatan pada bayi, terutama saat berusia 6-24 bulan karena saat itu adalah masa golden age (periode keemasan) pada bayi yang menjadi proses penting dalam tumbuh kembang anak. Tujuan penelitian ini adalah untuk mengetahui dampak kesehatan yang ditimbulkan akibat tradisi pemberian nasi papahan kepada bayi usia 6-24 bulan. Metode yang dilakukan adalah kajian literatur melalui database publikasi …

The Relationship Between Climate And Dengue Hemorrhagic Fever Incidence Rate In Malang Regency In 2022-2024, Aticobhita C. Pramono, Suprijandani Suprijandani, Marlik Marlik, Pratiwi Hermiyanti

Jurnal Epidemiologi Kesehatan Indonesia

Dengue Hemorrhagic Fever (DHF) is an infectious disease that poses a public health problem in tropical regions and is influenced by climatic factors such as temperature, rainfall, humidity, and wind speed. In 2023, Malang Regency recorded 1,018 cases with an incidence rate (IR) of 38.2 per 100,000 population. This study aims to analyze the relationship between climatic factors and the DF IR for the 2022–2024 period using an ecological design and Spearman’s correlation analysis. Climate data were obtained from the BMKG, while DF data were obtained from the Health Office. The results showed that only air temperature was significantly associated …

Fogarty-Funded Research Ethics Education In Latin America And The Caribbean: Progress Despite Ongoing Challenges, Timothy Daly, Ignacio Mastroleo, Luis L García Valiña, Irene Melamed, María Florencia Santi, Theresa J Ochoa, Manuela Fernández Pinto, Paul J Cummins, Bernardo García Camino, Cheryl Macpherson, Elizabeth Heitman, Florencia Luna

Faculty, Staff and Student Publications

Ten years have passed since the last regional assessment of the state of Fogarty International Center-funded research ethics education and challenges facing research ethics in Latin America and the Caribbean basin. Program directors and faculty from four international research ethics education programs met in Spring 2024 to discuss their progress, challenges, and future priorities. The themes that emerged from these discussions were the structural difficulties faced by regional ethicists, the use of pedagogical innovations to mitigate different barriers faced by fellows, and the need to anticipate future challenges for the region including climate change.

Development And Validation Of A New Formula To Predict Standard Pancreas Volume In Chinese Adults Using Body Surface Area, Domenech Asbun

All Publications

Background: Changes in pancreas volume have been reported in many disorders. In clinical practice, pre-disease total pancreas volume (TPV) is often unavailable for patients with pancreatic pathologies (e.g., tumors, cysts, or pancreatitis), as prior imaging may not exist or may reflect abnormal volumes. While three-dimensional (3D) computed tomography (CT) reconstruction provides accurate TPV measurements, its utility is limited in these scenarios, necessitating a predictive formula. However, no widely clinically accepted standard pancreas volume (SPV) formula currently exists. This study aims to develop an SPV prediction formula based on 3D CT reconstruction and the characteristics of Chinese adults.

Methods: The TPV …

Limosilactobacillus Reuteri Promotes The Expression And Secretion Of Enteroendocrine- And Enterocyte-Derived Hormones, Sara C Di Rienzi, Heather A Danhof, Micah D Forshee, Ari Roberts, Robert A Britton

Faculty, Staff and Students Publications

Intestinal microbes can beneficially impact host physiology, prompting investigations into the therapeutic usage of such microbes in a range of diseases. For example, human intestinal microbe Limosilactobacillus reuteri strains ATCC PTA 6475 and DSM 17938 are being considered for use for intestinal ailments, including colic, infection, and inflammation, as well as for non-intestinal ailments, including osteoporosis, wound healing, and autism spectrum disorder. While many of their beneficial properties are attributed to suppressing inflammatory responses, we postulated that L. reuteri may also regulate intestinal hormones to affect physiology within and outside of the gut. To determine if L. reuteri secreted factors …

Infectious Disease Traveler Mobile Application Based On Need Assessment Analysis In Malaysian Students, Farindira Vesti Rahmasari, Wulan Noviani, Cahya Damarjati, Titih Huriah, Ferika Indarwati, Umniyyah Agsanie, Tesaviani Kusumastiwi, Mallika Imwong, Chong Mei Chan

Media Kesehatan Masyarakat Indonesia

Major risks to world health are posed by infectious illnesses such as leptospirosis, hepatitis, malaria, dengue, and tuberculosis. Many diverse measures have been taken to fight infectious disease. However, cases persist despite these efforts, emphasizing the necessity for creative methods of managing and preventing disease. As it integrates mobile health (mHealth) solutions, the research can potentially revolutionize travel medicine. It is vital to give easily accessible and trustworthy health information that can lower the risks of infectious disease while traveling, as the number of students and the general public who travel is increasing. It was qualitative research. Qualitative study explores …

Social Determinants Of Covid-19 Morbidity In Indonesia: Observational District Level Analysis, Ade Heryana, Wiku Adisasmito, Dumilah Ayuningtyas

Media Kesehatan Masyarakat Indonesia

Since the COVID-19 pandemic globally struggled in late 2019, the global community has become aware that outbreaks of infectious diseases are associated with conditions beyond health factors, such as social, economic, demographic, geographic, and lifestyle. This paper aims to identify the influence of Social Determinants of Health (SDOH) on COVID-19 morbidity rates in Indonesia. The study analyzed morbidity cases during the second wave of the COVID-19 pandemic, namely the Delta variant wave. Multivariate analysis with linear regression was used to determine the predictors that affect COVID-19 morbidity in 128 districts/cities of the Java and Bali isles, which were controlled by …

Is Microbial Production A Good Option For Exceptionally Low Cost Monoclonal Antibodies For Global Access?, Vijay Yabannavar

Microbial Engineering III (MEIII)

Please click Additional Files below to see the full abstract

Poor Cancer Prevention And Detection In Zimbabwe, Kenyon C. Chipman

Journal of Nonprofit Innovation

Abstract

In the aftermath of the HIV/AIDS epidemic, Sub-Saharan Africa, particularly Zimbabwe, has witnessed a surge in noncommunicable diseases such as cancer. Despite the decline in HIV/AIDS and other cancer-associated illnesses like HPV, these diseases have set the stage for a growing cancer epidemic. Key contributing factors to this rise include a lack of knowledge about cancer among both patients and health professionals, the prevalence of cancer-associated communicable diseases, and limited accessibility to early detection and prevention services and resources. These factors have led to late diagnoses, increased burden on the healthcare system, and adverse effects on individuals and families. …

Caplacizumab Use In Immune-Mediated Thrombotic Thrombocytopenic Purpura: An International Multicentre Retrospective Cohort Study (The Capla 1000+ Project), Camila Masias

All Publications

Background: The anti-Von Willebrand Factor (VWF) nanobody caplacizumab is licensed for adults with immune-mediated thrombotic thrombocytopenic purpura (iTTP) in association with therapeutic plasma exchange (TPE) and immunosuppression. However, whether caplacizumab reduces mortality, and its optimal timing of initiation, is not completely settled.

Methods: This international, multicenter retrospective cohort study recruited patients from 2018 until 2023 and data collection took place from January 1st to June 30th 2023 in the participating centers. One thousand and fifteen patients were treated with daily TPE, immunosuppression with corticosteroids ± rituximab, and caplacizumab (caplacizumab group), which was compared to historic controls treated with TPE and …

Novel Drug Approvals 2024, Hanh Motilall, Kelley Maberry, Connor Quinter

Transformative Medicine

In 2024, the Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CEDR) approved 50 new drugs. As healthcare professionals, staying up to date on new therapies is vital. There are a wide range of medications that fall into several categories; therefore every professional can find a medication that pertains to their field. Three medications in particular will be described in detail outlining their background, the clinical trials highlighting their efficacy and safety, and lastly the prescribing information. The three medications are as follows, Xanomeline/Trospium Chloride (Cobenfy),Sotatercept-csrk (Winrevair) and Suzetrigine (Journavx).

Xanomeline/trospium chloride (Cobenfy) is a first of …

Behavioral Changes Of Tourists Caused By The Covid-19 And Management Response :During The Goto Travel Campaign In 2020, Yoshiki Murase

Japanese Society and Culture

This research set out to clarify how consumers perceive and change their tourism consumption as the government works on demand-stimulating measures such as the GoTo Travel campaign set up as a response to the worldwide spread of the COVID-19. The main purpose of this study is to give some suggestions about how the tourism industry can operate in such difficult circumstances and consider the implications for its management. Firstly, we referred to previous research and the latest data concerning travel agencies, the airline industry, and the accommodation and restaurant industry. These are the cornerstones of the tourism industry, and they …